FlyBase Gene Report: Dmel\Jhe

General Information

Symbol

Dmel\Jhe

Species

D. melanogaster

Name

Juvenile hormone esterase

Annotation Symbol

CG8425

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010052

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

carboxylesterase (3.1.1.1)

juvenile-hormone esterase (3.1.1.59)

Gene Summary

Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

JH, JH esterase

Key Links

Genomic Location

Cytogenetic map

52E5-52E5

Sequence location

2R:16,119,793..16,122,773 [+]

Recombination map

2-77

RefSeq locus

NT_033778 REGION:16119793..16122773

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables carboxylesterase activity

inferred from direct assay

(Birner-Gruenberger et al., 2012)

enables juvenile-hormone esterase activity

inferred from direct assay

(Hopkins et al., 2019, Crone et al., 2007, Campbell et al., 1992)

enables protein binding

inferred from physical interaction with FLYBASE:CG3776; FB:FBgn0035088

(Liu et al., 2007, Liu et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in behavioral response to ethanol

inferred from mutant phenotype

(Kong et al., 2010)

involved_in juvenile hormone catabolic process

inferred from direct assay

(Hopkins et al., 2019, Campbell et al., 1992)

involved_in male mating behavior

inferred from mutant phenotype

(Ellis and Carney, 2010)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from direct assay

(Liu et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CARBOXYLESTERASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

juvenile-hormone esterase activity

(1) juvenile hormone I + H2O = juvenile hormone I carboxylate + methanol + H(+) (3.1.1.59)

(2) juvenile hormone III + H2O = juvenile hormone III carboxylate + methanol + H(+) (3.1.1.59)

RHEA 16393: carboxylesterase activity

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+) (3.1.1.1)

RHEA 21164:

Summaries

Gene Snapshot

Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior. [Date last reviewed: 2019-09-19]

Gene Group (FlyBase)

CARBOXYLESTERASES -: Carboxylesterases catalyze the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Jhe for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1ZA98)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Jhe-RA

FBtr0087223

NM_079034

2026

579

Jhe-RB

FBtr0301751

NM_001169695

1979

579

Jhe-RC

FBtr0340021

NM_001299547

1967

579

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Jhe-PA

FBpp0086362

64.5

579

6.30

FBpp0290965

64.5

579

6.30

FBpp0309035

64.5

579

6.30

A1ZA98

NP_001286476

AHN56273

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

579 aa isoforms: Jhe-PA, Jhe-PB, Jhe-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jhe using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Jhe_1
Jhe_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.25

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT21-0

(Xu et al., 2011)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

organism

(Kethidi et al., 2005)

pupal stage

organism

(Kethidi et al., 2005)

adult stage

organism

(Kethidi et al., 2005)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Jhe transcript levels are low during embryogenesis. Peaks of expression are observed at each larval instar; these coincide with juvenile hormone expression peaks. Expression levels increase soon after pupal ecdysis. Jhe transcript is detected in both male and female adults.

(Kethidi et al., 2005)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrion

inferred from direct assay

(Liu et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Jhe in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Jhe

View exonic expression by tissue for Dmel\Jhe

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36780/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010052

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010052

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010052

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0010052

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Jhe

Transgenic constructs containing regulatory region of Jhe

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Jhe^GD5824

viable, with Scer\GAL4^Mef2.PR

Jhe^GD5824

viable, with Scer\GAL4^pnr-MD237

Jhe^GD5824

viable, with Scer\GAL4^tin.CΔ4

Jhe^GD5824

Other Phenotypes

Allele

abnormal mating | male | recessive

Jhe^e01859

chemical resistant

Jhe^e01859

increased rate of movement | conditional

Jhe^e01859

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\CES1

7 of 14

Yes

Hsap\CES4A

7 of 14

Yes

Hsap\CES2

6 of 14

Hsap\CES3

6 of 14

Yes

6 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Hsap\NLGN4Y

2 of 14

Hsap\TG

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\NCEH1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (39)

Rnor\Ces1a

7 of 14

Yes

Rnor\Ces1f

7 of 14

Yes

Rnor\Ces4a

7 of 14

Yes

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (39)

Mmus\Ces1a

7 of 14

Yes

Mmus\Ces1b

7 of 14

Yes

Mmus\Ces1c

7 of 14

Yes

Mmus\Ces1d

7 of 14

Yes

Mmus\Ces1e

7 of 14

Yes

Mmus\Ces1f

7 of 14

Yes

Mmus\Ces1g

7 of 14

Yes

Mmus\Ces4a

7 of 14

Yes

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

5 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (24)

Xtro\bche

3 of 13

Yes

Xtro\ces3.1

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ces5a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ptgr2

1 of 13

Xtro\tg

1 of 13

Xtro\unc93a.2

1 of 13

Danio rerio (Zebrafish) (23)

Drer\cel.1

5 of 14

Yes

Drer\ces2a

5 of 14

Yes

Drer\ces3

5 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Drer\si:dkey-30c15.17

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-193c22.1

1 of 14

Drer\tg

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (50)

Cele\cest-26

9 of 14

Yes

Cele\cest-30

9 of 14

Yes

Cele\cest-35.1

9 of 14

Yes

Cele\cest-35.2

9 of 14

Yes

Cele\cest-32

8 of 14

Yes

Cele\cest-17

6 of 14

Yes

6 of 14

6 of 14

6 of 14

5 of 14

Yes

Cele\cest-2.3

5 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

Yes

Cele\cest-2.1

4 of 14

Yes

Cele\cest-5.2

4 of 14

Yes

Cele\cest-8

4 of 14

Yes

Cele\cest-9.1

4 of 14

Yes

Cele\cest-9.2

4 of 14

Yes

Cele\cest-10

4 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\cest-3

3 of 14

Yes

Cele\cest-4

3 of 14

Yes

Cele\cest-5.1

3 of 14

Yes

Cele\cest-6

3 of 14

Yes

Cele\cest-12

3 of 14

Cele\ace-2

2 of 14

Cele\cest-7

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\ZK994.1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (49)

Agam\AgaP_AGAP005834

11 of 12

Yes

Agam\AgaP_AGAP005837

11 of 12

Yes

Agam\COEJHE3F

11 of 12

Yes

Agam\COEJHE4F

11 of 12

Yes

Agam\AgaP_AGAP001722

7 of 12

Yes

Agam\COEJHE1F

7 of 12

Yes

Agam\AgaP_AGAP005758

6 of 12

Agam\AgaP_AGAP006723

6 of 12

Agam\AgaP_AGAP006724

6 of 12

Yes

6 of 12

6 of 12

6 of 12

6 of 12

6 of 12

Yes

6 of 12

6 of 12

6 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

Yes

Agam\AgaP_AGAP011509

3 of 12

Yes

Agam\AgaP_AGAP011575

3 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (23)

Atha\AT1G19190

1 of 13

Yes

Atha\AT1G47480

1 of 13

Yes

Atha\AT1G49640

1 of 13

Yes

Atha\AT1G49650

1 of 13

Yes

Atha\AT1G68620

1 of 13

Yes

Atha\AT2G03550

1 of 13

Yes

Atha\AT2G45600

1 of 13

Yes

Atha\AT2G45610

1 of 13

Yes

Atha\AT3G27320

1 of 13

Yes

Atha\AT5G06570

1 of 13

Yes

Atha\CXE5

1 of 13

Yes

Atha\CXE12

1 of 13

Yes

Atha\CXE13

1 of 13

Yes

Atha\CXE16

1 of 13

Yes

Atha\CXE17

1 of 13

Yes

Atha\CXE18

1 of 13

Yes

Atha\CXE20

1 of 13

Yes

Atha\GID1A

1 of 13

Yes

Atha\GID1B

1 of 13

Yes

Atha\GID1C

1 of 13

Yes

Atha\ICME-LIKE1

1 of 13

Yes

Atha\ICME-LIKE2

1 of 13

Yes

Atha\PCME

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\SAY1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\SPCC417.12

5 of 12

Yes

Spom\SPAC8F11.08c

1 of 12

Yes

Spom\SPAC1039.03

1 of 12

Spom\SPAPB1A11.02

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Jhe. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

11 of 13

11 of 13

10 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

clt

9 of 13

Est-6

9 of 13

Est-P

9 of 13

gas

9 of 13

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

Gli

5 of 13

Nlg1

5 of 13

Ace

4 of 13

CG10339

4 of 13

Glt

3 of 13

Nlg3

3 of 13

Nlg4

3 of 13

Nrt

3 of 13

CG12869

2 of 13

Nlg2

2 of 13

CG30095

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CES1; carboxylesterase 1

7 of 14

114835

DRUG METABOLISM, ALTERED, CES1-RELATED

CES4A; carboxylesterase 4A

7 of 14

621153

CES2; carboxylesterase 2

6 of 14

605278

CES3; carboxylesterase 3

6 of 14

605279

CES5A; carboxylesterase 5A

6 of 14

618678

ACHE; acetylcholinesterase (Yt blood group)

4 of 14

100740

YT BLOOD GROUP ANTIGEN

CEL; carboxyl ester lipase

4 of 14

114840

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION; MODY8

maturity-onset diabetes of the young type 8

NLGN1; neuroligin 1

3 of 14

NEUROLIGIN 1; NLGN1

AUTISM, SUSCEPTIBILITY TO, 20; AUTS20

3 of 14

3 of 14

AUTISM, SUSCEPTIBILITY TO, X-LINKED 1; AUTSX1

NLGN4X; neuroligin 4 X-linked

3 of 14

300427

AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Jhe - CG3776

anti bait coimmunoprecipitation, tag visualisation, filter binding

(Liu et al., 2007)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010052

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Insect hormone biosynthesis

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Insect hormone biosynthesis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-77

Cytogenetic map

52E5-52E5

Sequence location

2R:16,119,793..16,122,773 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

52E5-52E5

Limits computationally determined from genome sequence between P{PZ}l(2)05070⁰⁵⁰⁷⁰&P{EP}CG8414^EP525 and P{EP}spin^EP645&P{lacW}spin^k09905

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

52F1-52F2

(Campbell, 2000.9.11)

Experimentally Determined Recombination Data

Location

2-77

(FlyBase, 2016)

2-81.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

57826

y¹ v¹; P{TRiP.HMJ21834}attP40

81162

y¹ w^*; TI{CRIMIC.TG4.0}Jhe^{CR01052-TG4.0}/SM6a

91254

y¹ w^*; TI{CRIMIC.TG4.0}Jhe^{CR01464-TG4.0}/SM6a

NIG-Fly

HMJ21834

y¹ v¹; P{TRiP.HMJ21834}attP40/CyO

HMJ23212

y¹ v¹; P{TRiP.HMJ23212}attP40/CyO

2RG-1365

y² VhaAC39-1^cho-1 v¹; P{U6-Jhe.NIG.sgRNA}attP40/CyO

VDRC

v44049

w¹¹¹⁸; P{GD5824}v44049

v44050

w¹¹¹⁸; P{GD5824}v44050

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010052

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010052

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Ortholog of B. mori juvenile-hormone-related gene (involved in JH biosynthesis, metabolism or signaling).

(Cheng et al., 2014)

Jhe enzyme has been purified from prepupae and characterised biochemically.

(Campbell et al., 1998)

Juvenile hormone metabolisms in two lines of adults is studied under normal conditions and after a short period of heat stress.

(Gruntenko et al., 1996)

Heat stress results in delay of oviposition and a decrease in juvenile hormone hydrolysis and fertility, which lasted several days after heat treatment.

(Gruntenko et al., 1996)

The course of changes in the activities of enzymes degrading juvenile hormone (JH) during development is studied and the possible role of the proteins in the regulation of JH titre in critical developmental periods and in reproduction are investigated.

(Khlebodarova et al., 1996)

Flies respond to stressing effects by a decrease in the level of Juvenile hormone (JH) hydrolysis, delay in oviposition and a decrease in fertility for a few days. The decrease in level of JH hydrolysis may be responsible for the response of the reproductive system to stress.

(Rauschenbach et al., 1996)

Females respond to heat stress by a decrease in activity of Dvir\Jhe. This decrease is effected through a decrease in protein. Dvir\Jhe metabolism in males does not change under heat stress.

(Rauschenbach et al., 1995)

The activity of Jhe in adult D.melanogaster females decreases in response to heat stress.

(Raushenbakh et al., 1995)

Radiometric assay showed juvenile hormone hydrolysing activity correlates inversely with juvenile hormone titre. Juvenile hormone esterase from D.melanogaster and D.simulans is sensitive to inhibition by esterase inhibitors OTFP and DFP.

(Campbell et al., 1992)

Abnormally low levels of juvenile hormone are synthesized in ap mutants.

(Altaratz et al., 1991)

Stage 8 and 9 oocytes transplanted into juvenile hormone (JH) deficient males and females were found to degenerate unless a JH analogue, ZR-515, was applied to the host shortly after implantation. These results suggest that JH is required for the initiation and continuation of vitellogenic uptake and oocyte development.

(Wilson, 1982)

Relationship to Other Genes

Source for database merge of

Additional comments

Annotation CG8425 split into CG30095, CG8425 (Jhe) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Jhe CG8425

(Campbell, 2001.2.6)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG8425

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Cheng et al., 2014, Ellis and Carney, 2010, Ni et al., 2010.12.1, Crone et al., 2007, Campbell, 2001.2.6, Campbell, 2001.2.6, Campbell, 2001.2.8, Campbell et al., 2001)

DmJhe

(Kethidi et al., 2005)

(Koyama et al., 2020, Gruntenko et al., 1996, Gruntenko et al., 1996, Jindra, 1994, de Loof et al., 1990)

JHE

(Cheng et al., 2014, Liu et al., 2008, Liu et al., 2007, Liu et al., 2007, Liu et al., 2007, Wozniak et al., 2004, Gruntenko et al., 2003, Campbell, 2001.2.8, Campbell et al., 2001, Harshman, 1999, Campbell et al., 1998)

Jhe

(Sun et al., 2025, Deanhardt et al., 2023, Örkenby et al., 2023, Banho et al., 2021, Kumar et al., 2021, Fowler et al., 2019, Gene Disruption Project members, 2018-, Xie et al., 2015, Xu et al., 2011, Ellis and Carney, 2010, Kong et al., 2010, Crone et al., 2007)

jhe

(Zhang et al., 2025, Rahman et al., 2017, Steiner et al., 2017, Abdou et al., 2011, Niwa et al., 2008)

Name Synonyms

JH esterase

(Jones et al., 2010, Niwa et al., 2008, Raushenbakh et al., 1995)

JH-esterase

(Gruntenko and Rauschenbach, 2005)

Juvenile hormone esterase

(Birner-Gruenberger et al., 2012, Davis et al., 2011, Mosqueira et al., 2010)

jh esterase

(Kethidi et al., 2005)

juvenile hormone esterase

(Niwa et al., 2008, Liu et al., 2007, Kethidi et al., 2005)

Secondary FlyBase IDs

FBgn0034077

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36780

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF304352

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1ZA98

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1ZA98

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36780/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010052

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010052

FlyMine - An integrated database for Drosophila genomics

FBgn0010052

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8425

MARRVEL_MODEL - MARRVEL (model organism gene)

36780

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010052

DroID - A comprehensive database of gene and protein interactions.

FBgn0010052

DRSC - Results frm RNAi screens

FBgn0010052

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Jhe_1
Jhe_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010052

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010052

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0010052

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010052

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013193

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Insect hormone biosynthesis

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Insect hormone biosynthesis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (82)

The following external sites may use different assemblies or annotations than FlyBase.

-0.25

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