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Gene Dmel\RpL23

General Information
Symbol	Dmel\RpL23	Species	D. melanogaster
Name	Ribosomal protein L23	Annotation symbol	CG3661
Feature type	protein_coding_gene	FlyBase ID	FBgn0010078
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	RpL17A
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	59B3-59B3	Sequence location	2R:18,741,898..18,743,211 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L23 is referred to in FlyBase by the symbol Dmel\RpL23 (CG3661, FBgn0010078). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization; neurogenesis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L14 conserved site; Ribosomal protein L14 domain; Ribosomal protein L14b/L23e. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634764_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL23. Gene sequence location is 2R:18741898..18743211.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59B3-59B3   Limits computationally determined from genome sequence between P{PZ}blw03972 and P{EP}EP627
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58F6-59A3   (determined by in situ hybridisation)   (Noselli and Vincent, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpL23 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Probable polymorphism between sequenced strain and source of SWP:P48159 causes 6aa discrepancy in center of protein, not due to frame shift
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL23-RA FBtr0071897  NM_079089   544   140
Additional Transcript Data & Comments
Reported size (kB)	0.6 (northern blot) (Noselli and Vincent, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL23-PA   FBpp0071808   14.9   140   11.48     NP_523813   AAF46914
Additional Polypeptide Data & Comments
Reported size (kDa)	140 (aa) (Noselli and Vincent, 1992)
Comments	The RpL23 protein is very basic (calculated pI of 11.47). (Noselli and Vincent, 1992)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L14b/L23e (IPR000218) Ribosomal protein L14 conserved site (IPR019972) Ribosomal protein L14 domain (IPR023571)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567243   AA696908   AA802537   AE013599 AAF46914   AI063352   AI063362   AI106980   AI107468   AI108814   AI109769   AI114374   AI134239   AI238596   AI257398   AI257470   AI257716   AI257727   AI258213   AI260361   AI260384   AI292964   AI293045   AI296603   AI386482   AI387351   AI387901   AI389814   AI389838   AI390027   AI402371   AI405516   AI516252   AI517301   AI534688   AY231892   AY433188   AY441376   BF501848   BG632139   BG634821   BG635840   BG637224   BG640311   BG640754   BG641060   BI141709   BI141758   BI141766   BI165003   BI166100   BI168671   BI170583   BI170769   BI171488   BI171784   BI213679   BI213879   BI216257   BI227497   BI227577   BI227636   BI227784   BI227802   BI227862   BI228483   BI228879   BI230089   BI230300   BI230386   BI230587   BI230944   BI231020   BI231182   BI232931   BI235209   BI235215   BI235584   BI237306   BI239305   BI240057   BI240278   BI240610   BI241967   BI242089   BI242145   BI351741   BI352050   BI352124   BI352321   BI352862   BI352893   BI353104   BI353130   BI353474   BI353653   BI353698   BI353995   BI355293   BI355327   BI355639   BI355852   BI356048   BI356427   BI356484   BI357602   BI357609   BI358021   BI358107   BI361563   BI361698   BI361782   BI361968   BI362825   BI363594   BI363607   BI363789   BI364190   BI364224   BI364375   BI364573   BI365353   BI365775   BI365807   BI365961   BI366650   BI366818   BI366839   BI367460   BI367484   BI368467   BI368497   BI368522   BI368837   BI369032   BI369378   BI369449   BI370578   BI370765   BI371495   BI372278   BI372860   BI373004   BI373110   BI373460   BI374168   BI375374   BI375420   BI375447   BI376089   BI481591   BI482663   BI484612   BI484755   BI485119   BI486041   BI486179   BI486260   BI563353   BI563484   BI563570   BI563614   BI563615   BI563940   BI564099   BI564381   BI564461   BI564507   BI564595   BI564657   BI564832   BI564894   BI564916   BI564983   BI565402   BI565565   BI565612   BI567137   BI567538   BI567694   BI567729   BI567765   BI567767   BI567980   BI568021   BI568138   BI568206   BI568250   BI568499   BI568520   BI568549   BI568621   BI568715   BI568998   BI569142   BI569343   BI569443   BI569854   BI569951   BI570212   BI570390   BI570455   BI570527   BI570828   BI571184   BI571239   BI571294   BI571428   BI571436   BI571857   BI571916   BI571999   BI572082   BI572209   BI572641   BI572664   BI572675   BI572804   BI572821   BI573086   BI573287   BI573617   BI573795   BI574012   BI574184   BI574373   BI574627   BI575372   BI575464   BI575774   BI575914   BI576167   BI576187   BI576338   BI576388   BI576593   BI576625   BI576650   BI576680   BI576953   BI576995   BI577001   BI577521   BI577630   BI577714   BI577772   BI577817   BI577904   BI580218   BI581082   BI582424   BI582455   BI582745   BI582838   BI583132   BI583162   BI583528   BI583613   BI584157   BI584162   BI584511   BI585004   BI585017   BI585224   BI585237   BI585290   BI585303   BI585963   BI586100   BI586186   BI586435   BI586509   BI586747   BI586766   BI586924   BI586979   BI587002   BI587040   BI587258   BI587394   BI587417   BI587506   BI587588   BI587608   BI587633   BI587634   BI587703   BI587723   BI587836   BI587857   BI587943   BI588185   BI588542   BI588594   BI588730   BI588881   BI589020   BI589126   BI589135   BI589190   BI589228   BI589457   BI589580   BI589647   BI589827   BI589904   BI590017   BI590037   BI590077   BI590198   BI590359   BI590452   BI591088   BI591567   BI591731   BI591897   BI591938   BI592122   BI592227   BI592248   BI592320   BI592328   BI592428   BI592469   BI592492   BI592578   BI592900   BI592936   BI592950   BI592992   BI593118   BI593206   BI593274   BI593328   BI593394   BI593408   BI604318   BI604583   BI604604   BI604624   BI604625   BI604712   BI604756   BI604804   BI604855   BI604862   BI605191   BI605235   BI605390   BI605497   BI605571   BI605670   BI605714   BI605843   BI606710   BI606942   BI606950   BI607107   BI607164   BI607181   BI607245   BI607487   BI607563   BI607578   BI607595   BI607880   BI607921   BI608343   BI608528   BI608634   BI608661   BI608692   BI608742   BI608924   BI609250   BI609265   BI609301   BI609493   BI609613   BI609678   BI609907   BI609923   BI610016   BI610023   BI610076   BI610132   BI610152   BI610202   BI610243   BI610351   BI610400   BI610423   BI610475   BI610502   BI610612   BI610757   BI610803   BI611382   BI611618   BI611842   BI611850   BI611890   BI611921   BI612230   BI612407   BI612560   BI612617   BI612765   BI612858   BI613207   BI613382   BI613720   BI613729   BI613909   BI613935   BI614077   BI614094   BI614218   BI614309   BI614466   BI614709   BI614909   BI614941   BI614991   BI615001   BI615337   BI615477   BI615514   BI615554   BI615608   BI615667   BI615735   BI615904   BI616125   BI616154   BI616345   BI616593   BI616605   BI616682   BI616705   BI616772   BI616882   BI616896   BI617012   BI617254   BI617443   BI617522   BI617757   BI617789   BI617862   BI618016   BI618043   BI618100   BI618445   BI618612   BI619185   BI619288   BI619452   BI619740   BI619747   BI619775   BI619850   BI619931   BI620046   BI620351   BI620578   BI620609   BI621180   BI621324   BI621368   BI621381   BI621412   BI621537   BI621611   BI621624   BI621849   BI621913   BI621951   BI621956   BI622161   BI622479   BI622717   BI622777   BI622892   BI622993   BI623011   BI623459   BI623703   BI623918   BI624253   BI624387   BI624431   BI624479   BI624501   BI624634   BI624675   BI624724   BI624940   BI625078   BI625103   BI625149   BI625496   BI625512   BI625572   BI625593   BI625671   BI625835   BI626329   BI626355   BI626373   BI626508   BI626565   BI626592   BI626611   BI626699   BI626847   BI626935   BI627004   BI627039   BI627196   BI627231   BI627325   BI627368   BI627438   BI627448   BI627450   BI627593   BI627733   BI628199   BI628250   BI628378   BI628452   BI628644   BI628651   BI628740   BI628864   BI629202   BI629474   BI629842   BI629933   BI629954   BI630023   BI630061   BI630100   BI630156   BI630355   BI630482   BI631123   BI631429   BI631797   BI633343   BI634096   BI634252   BI634253   BI634290   BI634389   BI634579   BI634619   BI634672   BI634750   BI634786   BI634894   BI635461   BI635906   BI637076   BI639278   BI639354   BI639655   BI640556   BI640636   BI640822   BI641704   BI641979   BP541026   BP541399   BP541846   BP543162   BP544313   BP545201   BP545940   BP546009   BP546122   BP546611   BP547202   BP547314   BP547330   BP548019   BP549810   BP549897   BP549916   BP550179   BP550445   BP550488   BP550531   BP550560   BP550839   BP551389   BP551504   BP551687   BP551913   BP552215   BP552930   BP553966   BP554241   BP554276   BP554829   BP554830   BP554887   BP555773   BP558594   BP559941   BP560367   BT031034   BT053700   BX006989   BX008124   BX012722   BX013991   BX014141   BX017332   BX019600   BX026364   BX027184   BX036272   BX038802   BX043263   BX053481   BX069122   BX072161   BX072350   BX072508   CA803366   CA803607   CA805270   CA805721   CA805977   CA806060   CK658884   CK660070   CK660211   CK661996   CO153543   CO153602   CO153773   CO153845   CO154360   CO154775   CO155031   CO155054   CO155133   CO155351   CO155449   CO155566   CO155578   CO156237   CO183140   CO183729   CO185075   CO185893   CO187768   CO191487   CO192860   CO193963   CO193984   CO194242   CO194676   CO273515   CO277923   CO280042   CO280239   CO283527   CO294898   CO295772   CO310580   CO314298   CO317632   CO317652   CO318396   CO318695   CO320206   CO325520   CO335638   CO335746   CO335784   CO335805   CO335939   CO336305   CO336574   CO336644   CO336907   CO336953   CO338811   DQ673438   EC060750   EC061269   EC061829   EC064098   EC064570   EC088885   EC201386   EC201569   EC203524   EC214163   EC215361   EC215979   EC217530   EC226487   EC248016   EC261048   EC261102   EC261367   EC261837   EC262005   EC262109   EC262940   EC263317   EC264443   EC264559   EC264674   EC265029   EC265651   EC266054   EC266366   EC266779   EC266857   EC266898   EC267383   EC267512   EC267730   EC267813   EL869892   EL869893   EL870301   EL873745   EL874453   EL874669   EL876168   EL876310   EL881286   EL887179   EL887237   EV575407   EV575794   EV576179   EV576889   EV577027   EV577379   EV578386   EV579256   EV579909   EV580571   EV581083   EV581502   EV581553   EV582630   EV582935   EV584290   EV584363   EV584675   EV584803   EV584805   EV584813   EV584820   EV586683   EV587000   EV587420   EV587530   EV589575   EV591038   EV591296   EV592678   EV592737   EV593923   EV593956   EV595611   EV598426   EV600128   GH747840   GH749429   GH750981   GH752421   GH755553   GH773324   GH775069   GH777198   GH785024   GH790357   GH790940   GH791627   GH796958   GH797601   GH797928   GH798113   GH800140   GH801159   GH802467   GH803134   GH805602   GH806694   GH807301   GH808291   GH813496   GH813579   GH817779   GH825681   GH827736   GH829656   GH836834   GH837898   GH837954   GH839371   GH839647   GH840990   GH843670   GH843740   GH844418   GH845836   GH849005   GH850042   GH852930   GH853540   GH858703   GH858704   GH860505   GH861254   GH861889   GH866224   GH866388   GH887742   GH889155   GH889939   GH889971   GH890775   GH890899   GH892668   GH895302   GH896820   GH897690   GH898457   GH900455   GH906297   GH914834   GH914989   GH918427   GH925645   GH927562   GH929245   GH929499   GH930256   GH934635   GH937590   M85295 AAA28867
UniProtKB/Swiss-Prot	P48159
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Noselli and Vincent, 1992)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2509.075 Larval Midgut    4461.1 Larval Hindgut    4160 Larval Malpighian Tubules    5087.2 Larval Fat Body    7480.8 Larval Salivary Gland    7463.9 Larval Trachea    5631.35 Larval Carcass    4430.475 Adult Head    4702.1 Adult Eye    6137.4 Adult Brain    3421.4 Adult Thoracic-Abdominal Ganglion    4675.4 Adult Crop    5828.8 Adult Midgut    5076.5 Adult Hindgut    4967.4 Adult Malpighian Tubules    5889.8 Adult Fat Body    5117.2 Adult Salivary Gland    11367.5 Adult Heart    6635.425 Adult VirginFemale Spermatheca    5200 Adult InseminatedFemale Spermatheca    5334.7 Adult Ovary    3388.5 Adult Testis    1166 Adult Male Accessory Gland    9297 Adult Carcass    5850.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2509.075) Larval Midgut  (4461.1) Larval Hindgut  (4160) Larval Malpighian Tubules  (5087.2) Larval Fat Body  (7480.8) Larval Salivary Gland  (7463.9) Larval Trachea  (5631.35) Larval Carcass  (4430.475) Adult Head  (4702.1) Adult Eye  (6137.4) Adult Brain  (3421.4) Adult Thoracic-Abdominal Ganglion  (4675.4) Adult Crop  (5828.8) Adult Midgut  (5076.5) Adult Hindgut  (4967.4) Adult Malpighian Tubules  (5889.8) Adult Fat Body  (5117.2) Adult Salivary Gland  (11367.5) Adult Heart  (6635.425) Adult VirginFemale Spermatheca  (5200) Adult InseminatedFemale Spermatheca  (5334.7) Adult Ovary  (3388.5) Adult Testis  (1166) Adult Male Accessory Gland  (9297) Adult Carcass  (5850.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2509.075) Larval Midgut  (4461.1) Larval Hindgut  (4160) Larval Malpighian Tubules  (5087.2) Larval Fat Body  (7480.8) Larval Salivary Gland  (7463.9) Larval Trachea  (5631.35) Larval Carcass  (4430.475) Adult Head  (4702.1) Adult Eye  (6137.4) Adult Brain  (3421.4) Adult Thoracic-Abdominal Ganglion  (4675.4) Adult Crop  (5828.8) Adult Midgut  (5076.5) Adult Hindgut  (4967.4) Adult Malpighian Tubules  (5889.8) Adult Fat Body  (5117.2) Adult Salivary Gland  (11367.5) Adult Heart  (6635.425) Adult VirginFemale Spermatheca  (5200) Adult InseminatedFemale Spermatheca  (5334.7) Adult Ovary  (3388.5) Adult Testis  (1166) Adult Male Accessory Gland  (9297) Adult Carcass  (5850.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2509.075 Larval Midgut    4461.1 Larval Hindgut    4160 Larval Malpighian Tubules    5087.2 Larval Fat Body    7480.8 Larval Salivary Gland    7463.9 Larval Trachea    5631.35 Larval Carcass    4430.475 Adult Head    4702.1 Adult Eye    6137.4 Adult Brain    3421.4 Adult Thoracic-Abdominal Ganglion    4675.4 Adult Crop    5828.8 Adult Midgut    5076.5 Adult Hindgut    4967.4 Adult Malpighian Tubules    5889.8 Adult Fat Body    5117.2 Adult Salivary Gland    11367.5 Adult Heart    6635.425 Adult VirginFemale Spermatheca    5200 Adult InseminatedFemale Spermatheca    5334.7 Adult Ovary    3388.5 Adult Testis    1166 Adult Male Accessory Gland    9297 Adult Carcass    5850.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2509.075 Larval Midgut    4461.1 Larval Hindgut    4160 Larval Malpighian Tubules    5087.2 Larval Fat Body    7480.8 Larval Salivary Gland    7463.9 Larval Trachea    5631.35 Larval Carcass    4430.475 Adult Head    4702.1 Adult Eye    6137.4 Adult Brain    3421.4 Adult Thoracic-Abdominal Ganglion    4675.4 Adult Crop    5828.8 Adult Midgut    5076.5 Adult Hindgut    4967.4 Adult Malpighian Tubules    5889.8 Adult Fat Body    5117.2 Adult Salivary Gland    11367.5 Adult Heart    6635.425 Adult VirginFemale Spermatheca    5200 Adult InseminatedFemale Spermatheca    5334.7 Adult Ovary    3388.5 Adult Testis    1166 Adult Male Accessory Gland    9297 Adult Carcass    5850.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2509.075) Larval Midgut  (4461.1) Larval Hindgut  (4160) Larval Malpighian Tubules  (5087.2) Larval Fat Body  (7480.8) Larval Salivary Gland  (7463.9) Larval Trachea  (5631.35) Larval Carcass  (4430.475) Adult Head  (4702.1) Adult Eye  (6137.4) Adult Brain  (3421.4) Adult Thoracic-Abdominal Ganglion  (4675.4) Adult Crop  (5828.8) Adult Midgut  (5076.5) Adult Hindgut  (4967.4) Adult Malpighian Tubules  (5889.8) Adult Fat Body  (5117.2) Adult Salivary Gland  (11367.5) Adult Heart  (6635.425) Adult VirginFemale Spermatheca  (5200) Adult InseminatedFemale Spermatheca  (5334.7) Adult Ovary  (3388.5) Adult Testis  (1166) Adult Male Accessory Gland  (9297) Adult Carcass  (5850.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2509.075) Larval Midgut  (4461.1) Larval Hindgut  (4160) Larval Malpighian Tubules  (5087.2) Larval Fat Body  (7480.8) Larval Salivary Gland  (7463.9) Larval Trachea  (5631.35) Larval Carcass  (4430.475) Adult Head  (4702.1) Adult Eye  (6137.4) Adult Brain  (3421.4) Adult Thoracic-Abdominal Ganglion  (4675.4) Adult Crop  (5828.8) Adult Midgut  (5076.5) Adult Hindgut  (4967.4) Adult Malpighian Tubules  (5889.8) Adult Fat Body  (5117.2) Adult Salivary Gland  (11367.5) Adult Heart  (6635.425) Adult VirginFemale Spermatheca  (5200) Adult InseminatedFemale Spermatheca  (5334.7) Adult Ovary  (3388.5) Adult Testis  1166 Adult Male Accessory Gland  (9297) Adult Carcass  (5850.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2509.075 Larval Midgut    4461.1 Larval Hindgut    4160 Larval Malpighian Tubules    5087.2 Larval Fat Body    7480.8 Larval Salivary Gland    7463.9 Larval Trachea    5631.35 Larval Carcass    4430.475 Adult Head    4702.1 Adult Eye    6137.4 Adult Brain    3421.4 Adult Thoracic-Abdominal Ganglion    4675.4 Adult Crop    5828.8 Adult Midgut    5076.5 Adult Hindgut    4967.4 Adult Malpighian Tubules    5889.8 Adult Fat Body    5117.2 Adult Salivary Gland    11367.5 Adult Heart    6635.425 Adult VirginFemale Spermatheca    5200 Adult InseminatedFemale Spermatheca    5334.7 Adult Ovary    3388.5 Adult Testis    1166 Adult Male Accessory Gland    9297 Adult Carcass    5850.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4702.1   NA  Eye    6137.4   NA  Brain    3421.4   2509.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4675.4   NA  Crop    5828.8   4461.1  Midgut    5076.5   4160  Hindgut    4967.4   5087.2  Malpighian Tubules    5889.8   7480.8  Fat Body    5117.2   7463.9  Salivary Gland    11367.5   NA  Heart    6635.425   5631.35  Trachea    NA   NA  VirginFemale Spermatheca    5200   NA  InseminatedFemale Spermatheca    5334.7   NA  Ovary    3388.5   NA  Testis    1166   NA  Male Accessory Gland    9297   4430.475  Carcass    5850.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1290 central nervous system, larvae L3    787 central nervous system, pupae P8    400 head, virgin 1-day female    347 head, virgin 4-day female    549 head, virgin 20-day female    820 head, mated 1-day female    366 head, mated 4-day female    747 head, mated 20-day female    749 head, mated 1-day male    366 head, mated 4-day male    519 head, mated 20-day male    793 salivary gland, larvae L3 wandering    1153 salivary gland, white prepupae    1177 digestive system, larvae L3 wandering    730 digestive system, 1-day adult    996 digestive system, 4-day adult    779 digestive system, 20-day adult    865 fat body, larvae L3 wandering    693 fat body, white prepupae    439 fat body, pupae P8    875 carcass, larvae L3 wandering    955 carcass, 1-day adult    444 carcass, 4-day adult    577 carcass, 20-day adult    608 ovary, virgin 4-day female    837 ovary, mated 4-day female    687 testis, mated 4-day male    494 accessory gland, mated 4-day male    1189 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (1290) central nervous system, larvae L3  (787) central nervous system, pupae P8  (400) head, virgin 1-day female  (347) head, virgin 4-day female  (549) head, virgin 20-day female  (820) head, mated 1-day female  (366) head, mated 4-day female  (747) head, mated 20-day female  (749) head, mated 1-day male  (366) head, mated 4-day male  (519) head, mated 20-day male  (793) salivary gland, larvae L3 wandering  (1153) salivary gland, white prepupae  (1177) digestive system, larvae L3 wandering  (730) digestive system, 1-day adult  (996) digestive system, 4-day adult  (779) digestive system, 20-day adult  (865) fat body, larvae L3 wandering  (693) fat body, white prepupae  (439) fat body, pupae P8  (875) carcass, larvae L3 wandering  (955) carcass, 1-day adult  (444) carcass, 4-day adult  (577) carcass, 20-day adult  (608) ovary, virgin 4-day female  (837) ovary, mated 4-day female  (687) testis, mated 4-day male  (494) accessory gland, mated 4-day male  (1189) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (1290) central nervous system, larvae L3  (787) central nervous system, pupae P8  (400) head, virgin 1-day female  (347) head, virgin 4-day female  (549) head, virgin 20-day female  (820) head, mated 1-day female  (366) head, mated 4-day female  (747) head, mated 20-day female  (749) head, mated 1-day male  (366) head, mated 4-day male  (519) head, mated 20-day male  (793) salivary gland, larvae L3 wandering  (1153) salivary gland, white prepupae  (1177) digestive system, larvae L3 wandering  (730) digestive system, 1-day adult  (996) digestive system, 4-day adult  (779) digestive system, 20-day adult  (865) fat body, larvae L3 wandering  (693) fat body, white prepupae  (439) fat body, pupae P8  (875) carcass, larvae L3 wandering  (955) carcass, 1-day adult  (444) carcass, 4-day adult  (577) carcass, 20-day adult  (608) ovary, virgin 4-day female  (837) ovary, mated 4-day female  (687) testis, mated 4-day male  (494) accessory gland, mated 4-day male  (1189) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1290 central nervous system, larvae L3    787 central nervous system, pupae P8    400 head, virgin 1-day female    347 head, virgin 4-day female    549 head, virgin 20-day female    820 head, mated 1-day female    366 head, mated 4-day female    747 head, mated 20-day female    749 head, mated 1-day male    366 head, mated 4-day male    519 head, mated 20-day male    793 salivary gland, larvae L3 wandering    1153 salivary gland, white prepupae    1177 digestive system, larvae L3 wandering    730 digestive system, 1-day adult    996 digestive system, 4-day adult    779 digestive system, 20-day adult    865 fat body, larvae L3 wandering    693 fat body, white prepupae    439 fat body, pupae P8    875 carcass, larvae L3 wandering    955 carcass, 1-day adult    444 carcass, 4-day adult    577 carcass, 20-day adult    608 ovary, virgin 4-day female    837 ovary, mated 4-day female    687 testis, mated 4-day male    494 accessory gland, mated 4-day male    1189 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1290 central nervous system, larvae L3    787 central nervous system, pupae P8    400 head, virgin 1-day female    347 head, virgin 4-day female    549 head, virgin 20-day female    820 head, mated 1-day female    366 head, mated 4-day female    747 head, mated 20-day female    749 head, mated 1-day male    366 head, mated 4-day male    519 head, mated 20-day male    793 salivary gland, larvae L3 wandering    1153 salivary gland, white prepupae    1177 digestive system, larvae L3 wandering    730 digestive system, 1-day adult    996 digestive system, 4-day adult    779 digestive system, 20-day adult    865 fat body, larvae L3 wandering    693 fat body, white prepupae    439 fat body, pupae P8    875 carcass, larvae L3 wandering    955 carcass, 1-day adult    444 carcass, 4-day adult    577 carcass, 20-day adult    608 ovary, virgin 4-day female    837 ovary, mated 4-day female    687 testis, mated 4-day male    494 accessory gland, mated 4-day male    1189 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (1290) central nervous system, larvae L3  (787) central nervous system, pupae P8  (400) head, virgin 1-day female  (347) head, virgin 4-day female  (549) head, virgin 20-day female  (820) head, mated 1-day female  (366) head, mated 4-day female  (747) head, mated 20-day female  (749) head, mated 1-day male  (366) head, mated 4-day male  (519) head, mated 20-day male  (793) salivary gland, larvae L3 wandering  (1153) salivary gland, white prepupae  (1177) digestive system, larvae L3 wandering  (730) digestive system, 1-day adult  (996) digestive system, 4-day adult  (779) digestive system, 20-day adult  (865) fat body, larvae L3 wandering  (693) fat body, white prepupae  (439) fat body, pupae P8  (875) carcass, larvae L3 wandering  (955) carcass, 1-day adult  (444) carcass, 4-day adult  (577) carcass, 20-day adult  (608) ovary, virgin 4-day female  (837) ovary, mated 4-day female  (687) testis, mated 4-day male  (494) accessory gland, mated 4-day male  (1189) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (1290) central nervous system, larvae L3  (787) central nervous system, pupae P8  (400) head, virgin 1-day female  (347) head, virgin 4-day female  (549) head, virgin 20-day female  (820) head, mated 1-day female  (366) head, mated 4-day female  (747) head, mated 20-day female  (749) head, mated 1-day male  (366) head, mated 4-day male  (519) head, mated 20-day male  (793) salivary gland, larvae L3 wandering  (1153) salivary gland, white prepupae  (1177) digestive system, larvae L3 wandering  (730) digestive system, 1-day adult  (996) digestive system, 4-day adult  (779) digestive system, 20-day adult  (865) fat body, larvae L3 wandering  (693) fat body, white prepupae  (439) fat body, pupae P8  (875) carcass, larvae L3 wandering  (955) carcass, 1-day adult  (444) carcass, 4-day adult  (577) carcass, 20-day adult  (608) ovary, virgin 4-day female  (837) ovary, mated 4-day female  (687) testis, mated 4-day male  (494) accessory gland, mated 4-day male  (1189) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1290 central nervous system, larvae L3    787 central nervous system, pupae P8    400 head, virgin 1-day female    347 head, virgin 4-day female    549 head, virgin 20-day female    820 head, mated 1-day female    366 head, mated 4-day female    747 head, mated 20-day female    749 head, mated 1-day male    366 head, mated 4-day male    519 head, mated 20-day male    793 salivary gland, larvae L3 wandering    1153 salivary gland, white prepupae    1177 digestive system, larvae L3 wandering    730 digestive system, 1-day adult    996 digestive system, 4-day adult    779 digestive system, 20-day adult    865 fat body, larvae L3 wandering    693 fat body, white prepupae    439 fat body, pupae P8    875 carcass, larvae L3 wandering    955 carcass, 1-day adult    444 carcass, 4-day adult    577 carcass, 20-day adult    608 ovary, virgin 4-day female    837 ovary, mated 4-day female    687 testis, mated 4-day male    494 accessory gland, mated 4-day male    1189 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1695 embryo 02-04hr    2770 embryo 04-06hr    2203 embryo 06-08hr    2671 embryo 08-10hr    2866 embryo 10-12hr    4593 embryo 12-14hr    1969 embryo 14-16hr    2312 embryo 16-18hr    2198 embryo 18-20hr    2704 embryo 20-22hr    3405 embryo 22-24hr    2446 larva L1    3321 larva L2    2653 larva L3 12hr old    2577 larva L3 puffstage 1-2    1851 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    1618 white prepupae new    1657 white prepupae 12hr    1449 white prepupae 24hr    1535 pupae 2d postWPP    1224 pupae 3d postWPP    913 pupae 4d postWPP    1032 adult male 01day    828 adult male 05day    915 adult male 30day    940 adult female 01day    1983 adult female 05day    1934 adult female 30day    2147 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1695) embryo 02-04hr  (2770) embryo 04-06hr  (2203) embryo 06-08hr  (2671) embryo 08-10hr  (2866) embryo 10-12hr  (4593) embryo 12-14hr  (1969) embryo 14-16hr  (2312) embryo 16-18hr  (2198) embryo 18-20hr  (2704) embryo 20-22hr  (3405) embryo 22-24hr  (2446) larva L1  (3321) larva L2  (2653) larva L3 12hr old  (2577) larva L3 puffstage 1-2  (1851) larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (1618) white prepupae new  (1657) white prepupae 12hr  (1449) white prepupae 24hr  (1535) pupae 2d postWPP  (1224) pupae 3d postWPP  (913) pupae 4d postWPP  (1032) adult male 01day  (828) adult male 05day  (915) adult male 30day  (940) adult female 01day  (1983) adult female 05day  (1934) adult female 30day  (2147) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (1695) embryo 02-04hr  (2770) embryo 04-06hr  (2203) embryo 06-08hr  (2671) embryo 08-10hr  (2866) embryo 10-12hr  (4593) embryo 12-14hr  (1969) embryo 14-16hr  (2312) embryo 16-18hr  (2198) embryo 18-20hr  (2704) embryo 20-22hr  (3405) embryo 22-24hr  (2446) larva L1  (3321) larva L2  (2653) larva L3 12hr old  (2577) larva L3 puffstage 1-2  (1851) larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (1618) white prepupae new  (1657) white prepupae 12hr  (1449) white prepupae 24hr  (1535) pupae 2d postWPP  (1224) pupae 3d postWPP  (913) pupae 4d postWPP  (1032) adult male 01day  (828) adult male 05day  (915) adult male 30day  (940) adult female 01day  (1983) adult female 05day  (1934) adult female 30day  (2147) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1695 embryo 02-04hr    2770 embryo 04-06hr    2203 embryo 06-08hr    2671 embryo 08-10hr    2866 embryo 10-12hr    4593 embryo 12-14hr    1969 embryo 14-16hr    2312 embryo 16-18hr    2198 embryo 18-20hr    2704 embryo 20-22hr    3405 embryo 22-24hr    2446 larva L1    3321 larva L2    2653 larva L3 12hr old    2577 larva L3 puffstage 1-2    1851 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    1618 white prepupae new    1657 white prepupae 12hr    1449 white prepupae 24hr    1535 pupae 2d postWPP    1224 pupae 3d postWPP    913 pupae 4d postWPP    1032 adult male 01day    828 adult male 05day    915 adult male 30day    940 adult female 01day    1983 adult female 05day    1934 adult female 30day    2147 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1695 embryo 02-04hr    2770 embryo 04-06hr    2203 embryo 06-08hr    2671 embryo 08-10hr    2866 embryo 10-12hr    4593 embryo 12-14hr    1969 embryo 14-16hr    2312 embryo 16-18hr    2198 embryo 18-20hr    2704 embryo 20-22hr    3405 embryo 22-24hr    2446 larva L1    3321 larva L2    2653 larva L3 12hr old    2577 larva L3 puffstage 1-2    1851 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    1618 white prepupae new    1657 white prepupae 12hr    1449 white prepupae 24hr    1535 pupae 2d postWPP    1224 pupae 3d postWPP    913 pupae 4d postWPP    1032 adult male 01day    828 adult male 05day    915 adult male 30day    940 adult female 01day    1983 adult female 05day    1934 adult female 30day    2147 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1695) embryo 02-04hr  (2770) embryo 04-06hr  (2203) embryo 06-08hr  (2671) embryo 08-10hr  (2866) embryo 10-12hr  (4593) embryo 12-14hr  (1969) embryo 14-16hr  (2312) embryo 16-18hr  (2198) embryo 18-20hr  (2704) embryo 20-22hr  (3405) embryo 22-24hr  (2446) larva L1  (3321) larva L2  (2653) larva L3 12hr old  (2577) larva L3 puffstage 1-2  (1851) larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (1618) white prepupae new  (1657) white prepupae 12hr  (1449) white prepupae 24hr  (1535) pupae 2d postWPP  (1224) pupae 3d postWPP  (913) pupae 4d postWPP  (1032) adult male 01day  (828) adult male 05day  (915) adult male 30day  (940) adult female 01day  (1983) adult female 05day  (1934) adult female 30day  (2147) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (1695) embryo 02-04hr  (2770) embryo 04-06hr  (2203) embryo 06-08hr  (2671) embryo 08-10hr  (2866) embryo 10-12hr  (4593) embryo 12-14hr  (1969) embryo 14-16hr  (2312) embryo 16-18hr  (2198) embryo 18-20hr  (2704) embryo 20-22hr  (3405) embryo 22-24hr  (2446) larva L1  (3321) larva L2  (2653) larva L3 12hr old  (2577) larva L3 puffstage 1-2  (1851) larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (1618) white prepupae new  (1657) white prepupae 12hr  (1449) white prepupae 24hr  (1535) pupae 2d postWPP  (1224) pupae 3d postWPP  (913) pupae 4d postWPP  (1032) adult male 01day  (828) adult male 05day  (915) adult male 30day  (940) adult female 01day  (1983) adult female 05day  (1934) adult female 30day  (2147) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1695 embryo 02-04hr    2770 embryo 04-06hr    2203 embryo 06-08hr    2671 embryo 08-10hr    2866 embryo 10-12hr    4593 embryo 12-14hr    1969 embryo 14-16hr    2312 embryo 16-18hr    2198 embryo 18-20hr    2704 embryo 20-22hr    3405 embryo 22-24hr    2446 larva L1    3321 larva L2    2653 larva L3 12hr old    2577 larva L3 puffstage 1-2    1851 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    1618 white prepupae new    1657 white prepupae 12hr    1449 white prepupae 24hr    1535 pupae 2d postWPP    1224 pupae 3d postWPP    913 pupae 4d postWPP    1032 adult male 01day    828 adult male 05day    915 adult male 30day    940 adult female 01day    1983 adult female 05day    1934 adult female 30day    2147 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5586 Schneider line 2 Sg4    5080 embryonic 1182-4H    2351 embryonic GM2    897 embryonic Kc167    2071 embryonic S1    3228 embryonic S3    1862 leg disc CME L1    3108 wing disc CME-W2    2665 wing disc ML-DmD8    4653 wing disc ML-DmD9    2384 wing disc ML-DmD16-c3    2260 wing disc ML-DmD21    9047 wing disc ML-DmD32    2365 haltere disc ML-DmD17-c3    2871 eye-antennal disc ML-DmD11    3263 antennal disc ML-DmD20-c5    5206 mixed discs ML-DmD4-c1    3009 CNS ML-DmBG1-c1    3023 CNS ML-DmBG2-c2    2129 tumorous blood cells mbn2    1668 ovary fGS/OSS    504 ovary OSC    374 ovary OSS    249 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (5586) Schneider line 2 Sg4  (5080) embryonic 1182-4H  (2351) embryonic GM2  (897) embryonic Kc167  (2071) embryonic S1  (3228) embryonic S3  (1862) leg disc CME L1  (3108) wing disc CME-W2  (2665) wing disc ML-DmD8  (4653) wing disc ML-DmD9  (2384) wing disc ML-DmD16-c3  (2260) wing disc ML-DmD21  (9047) wing disc ML-DmD32  (2365) haltere disc ML-DmD17-c3  (2871) eye-antennal disc ML-DmD11  (3263) antennal disc ML-DmD20-c5  (5206) mixed discs ML-DmD4-c1  (3009) CNS ML-DmBG1-c1  (3023) CNS ML-DmBG2-c2  (2129) tumorous blood cells mbn2  (1668) ovary fGS/OSS  (504) ovary OSC  (374) ovary OSS  (249) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (5586) Schneider line 2 Sg4  (5080) embryonic 1182-4H  (2351) embryonic GM2  (897) embryonic Kc167  (2071) embryonic S1  (3228) embryonic S3  (1862) leg disc CME L1  (3108) wing disc CME-W2  (2665) wing disc ML-DmD8  (4653) wing disc ML-DmD9  (2384) wing disc ML-DmD16-c3  (2260) wing disc ML-DmD21  (9047) wing disc ML-DmD32  (2365) haltere disc ML-DmD17-c3  (2871) eye-antennal disc ML-DmD11  (3263) antennal disc ML-DmD20-c5  (5206) mixed discs ML-DmD4-c1  (3009) CNS ML-DmBG1-c1  (3023) CNS ML-DmBG2-c2  (2129) tumorous blood cells mbn2  (1668) ovary fGS/OSS  (504) ovary OSC  (374) ovary OSS  (249) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5586 Schneider line 2 Sg4    5080 embryonic 1182-4H    2351 embryonic GM2    897 embryonic Kc167    2071 embryonic S1    3228 embryonic S3    1862 leg disc CME L1    3108 wing disc CME-W2    2665 wing disc ML-DmD8    4653 wing disc ML-DmD9    2384 wing disc ML-DmD16-c3    2260 wing disc ML-DmD21    9047 wing disc ML-DmD32    2365 haltere disc ML-DmD17-c3    2871 eye-antennal disc ML-DmD11    3263 antennal disc ML-DmD20-c5    5206 mixed discs ML-DmD4-c1    3009 CNS ML-DmBG1-c1    3023 CNS ML-DmBG2-c2    2129 tumorous blood cells mbn2    1668 ovary fGS/OSS    504 ovary OSC    374 ovary OSS    249 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5586 Schneider line 2 Sg4    5080 embryonic 1182-4H    2351 embryonic GM2    897 embryonic Kc167    2071 embryonic S1    3228 embryonic S3    1862 leg disc CME L1    3108 wing disc CME-W2    2665 wing disc ML-DmD8    4653 wing disc ML-DmD9    2384 wing disc ML-DmD16-c3    2260 wing disc ML-DmD21    9047 wing disc ML-DmD32    2365 haltere disc ML-DmD17-c3    2871 eye-antennal disc ML-DmD11    3263 antennal disc ML-DmD20-c5    5206 mixed discs ML-DmD4-c1    3009 CNS ML-DmBG1-c1    3023 CNS ML-DmBG2-c2    2129 tumorous blood cells mbn2    1668 ovary fGS/OSS    504 ovary OSC    374 ovary OSS    249 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (5586) Schneider line 2 Sg4  (5080) embryonic 1182-4H  (2351) embryonic GM2  (897) embryonic Kc167  (2071) embryonic S1  (3228) embryonic S3  (1862) leg disc CME L1  (3108) wing disc CME-W2  (2665) wing disc ML-DmD8  (4653) wing disc ML-DmD9  (2384) wing disc ML-DmD16-c3  (2260) wing disc ML-DmD21  (9047) wing disc ML-DmD32  (2365) haltere disc ML-DmD17-c3  (2871) eye-antennal disc ML-DmD11  (3263) antennal disc ML-DmD20-c5  (5206) mixed discs ML-DmD4-c1  (3009) CNS ML-DmBG1-c1  (3023) CNS ML-DmBG2-c2  (2129) tumorous blood cells mbn2  (1668) ovary fGS/OSS  (504) ovary OSC  (374) ovary OSS  (249) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (5586) Schneider line 2 Sg4  (5080) embryonic 1182-4H  (2351) embryonic GM2  (897) embryonic Kc167  (2071) embryonic S1  (3228) embryonic S3  (1862) leg disc CME L1  (3108) wing disc CME-W2  (2665) wing disc ML-DmD8  (4653) wing disc ML-DmD9  (2384) wing disc ML-DmD16-c3  (2260) wing disc ML-DmD21  (9047) wing disc ML-DmD32  (2365) haltere disc ML-DmD17-c3  (2871) eye-antennal disc ML-DmD11  (3263) antennal disc ML-DmD20-c5  (5206) mixed discs ML-DmD4-c1  (3009) CNS ML-DmBG1-c1  (3023) CNS ML-DmBG2-c2  (2129) tumorous blood cells mbn2  (1668) ovary fGS/OSS  (504) ovary OSC  (374) ovary OSS  (249) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5586 Schneider line 2 Sg4    5080 embryonic 1182-4H    2351 embryonic GM2    897 embryonic Kc167    2071 embryonic S1    3228 embryonic S3    1862 leg disc CME L1    3108 wing disc CME-W2    2665 wing disc ML-DmD8    4653 wing disc ML-DmD9    2384 wing disc ML-DmD16-c3    2260 wing disc ML-DmD21    9047 wing disc ML-DmD32    2365 haltere disc ML-DmD17-c3    2871 eye-antennal disc ML-DmD11    3263 antennal disc ML-DmD20-c5    5206 mixed discs ML-DmD4-c1    3009 CNS ML-DmBG1-c1    3023 CNS ML-DmBG2-c2    2129 tumorous blood cells mbn2    1668 ovary fGS/OSS    504 ovary OSC    374 ovary OSS    249 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    777 cold shock, 4-day adult    631 heat shock, 4-day adult    1505 Cadmium 50 mM 6 hrs, larvae L3    2236 Cadmium 50 mM 12 hrs, larvae L3    1296 Cadmium 50 mM 48 hrs, 4-day adult    1024 Cadmium 100 mM 48 hrs, 4-day adult    811 Copper 0.5 mM 12 hrs, larvae L3    876 Copper 15 mM 48 hrs, 4-day adult    303 Zinc 5 mM 12 hrs, larvae L3    747 Zinc 4.5 mM 48 hrs, 4-day adult    353 Ethanol 2.5% 3 hrs, larvae L3    1354 Ethanol 5% 3 hrs, larvae L3    1293 Ethanol 10% 3 hrs, larvae L3    1488 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    848 Caffeine 25 mg/ml 48 hrs, 4-day adult    548 Paraquat 5 mM 48 hrs, 4-day adult    933 Paraquat 10 mM 48 hrs, 4-day adult    1386 Rotenone 2 μg 12 hrs, larvae L3    1390 Rotenone 8 μg 12 hrs, larvae L3    1872 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (777) cold shock, 4-day adult  (631) heat shock, 4-day adult  (1505) Cadmium 50 mM 6 hrs, larvae L3  (2236) Cadmium 50 mM 12 hrs, larvae L3  (1296) Cadmium 50 mM 48 hrs, 4-day adult  (1024) Cadmium 100 mM 48 hrs, 4-day adult  (811) Copper 0.5 mM 12 hrs, larvae L3  (876) Copper 15 mM 48 hrs, 4-day adult  (303) Zinc 5 mM 12 hrs, larvae L3  (747) Zinc 4.5 mM 48 hrs, 4-day adult  (353) Ethanol 2.5% 3 hrs, larvae L3  (1354) Ethanol 5% 3 hrs, larvae L3  (1293) Ethanol 10% 3 hrs, larvae L3  (1488) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1107) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (848) Caffeine 25 mg/ml 48 hrs, 4-day adult  (548) Paraquat 5 mM 48 hrs, 4-day adult  (933) Paraquat 10 mM 48 hrs, 4-day adult  (1386) Rotenone 2 μg 12 hrs, larvae L3  (1390) Rotenone 8 μg 12 hrs, larvae L3  (1872) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (777) cold shock, 4-day adult  (631) heat shock, 4-day adult  (1505) Cadmium 50 mM 6 hrs, larvae L3  (2236) Cadmium 50 mM 12 hrs, larvae L3  (1296) Cadmium 50 mM 48 hrs, 4-day adult  (1024) Cadmium 100 mM 48 hrs, 4-day adult  (811) Copper 0.5 mM 12 hrs, larvae L3  (876) Copper 15 mM 48 hrs, 4-day adult  (303) Zinc 5 mM 12 hrs, larvae L3  (747) Zinc 4.5 mM 48 hrs, 4-day adult  (353) Ethanol 2.5% 3 hrs, larvae L3  (1354) Ethanol 5% 3 hrs, larvae L3  (1293) Ethanol 10% 3 hrs, larvae L3  (1488) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1107) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (848) Caffeine 25 mg/ml 48 hrs, 4-day adult  (548) Paraquat 5 mM 48 hrs, 4-day adult  (933) Paraquat 10 mM 48 hrs, 4-day adult  (1386) Rotenone 2 μg 12 hrs, larvae L3  (1390) Rotenone 8 μg 12 hrs, larvae L3  (1872) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    777 cold shock, 4-day adult    631 heat shock, 4-day adult    1505 Cadmium 50 mM 6 hrs, larvae L3    2236 Cadmium 50 mM 12 hrs, larvae L3    1296 Cadmium 50 mM 48 hrs, 4-day adult    1024 Cadmium 100 mM 48 hrs, 4-day adult    811 Copper 0.5 mM 12 hrs, larvae L3    876 Copper 15 mM 48 hrs, 4-day adult    303 Zinc 5 mM 12 hrs, larvae L3    747 Zinc 4.5 mM 48 hrs, 4-day adult    353 Ethanol 2.5% 3 hrs, larvae L3    1354 Ethanol 5% 3 hrs, larvae L3    1293 Ethanol 10% 3 hrs, larvae L3    1488 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    848 Caffeine 25 mg/ml 48 hrs, 4-day adult    548 Paraquat 5 mM 48 hrs, 4-day adult    933 Paraquat 10 mM 48 hrs, 4-day adult    1386 Rotenone 2 μg 12 hrs, larvae L3    1390 Rotenone 8 μg 12 hrs, larvae L3    1872 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    777 cold shock, 4-day adult    631 heat shock, 4-day adult    1505 Cadmium 50 mM 6 hrs, larvae L3    2236 Cadmium 50 mM 12 hrs, larvae L3    1296 Cadmium 50 mM 48 hrs, 4-day adult    1024 Cadmium 100 mM 48 hrs, 4-day adult    811 Copper 0.5 mM 12 hrs, larvae L3    876 Copper 15 mM 48 hrs, 4-day adult    303 Zinc 5 mM 12 hrs, larvae L3    747 Zinc 4.5 mM 48 hrs, 4-day adult    353 Ethanol 2.5% 3 hrs, larvae L3    1354 Ethanol 5% 3 hrs, larvae L3    1293 Ethanol 10% 3 hrs, larvae L3    1488 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    848 Caffeine 25 mg/ml 48 hrs, 4-day adult    548 Paraquat 5 mM 48 hrs, 4-day adult    933 Paraquat 10 mM 48 hrs, 4-day adult    1386 Rotenone 2 μg 12 hrs, larvae L3    1390 Rotenone 8 μg 12 hrs, larvae L3    1872 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (777) cold shock, 4-day adult  (631) heat shock, 4-day adult  (1505) Cadmium 50 mM 6 hrs, larvae L3  (2236) Cadmium 50 mM 12 hrs, larvae L3  (1296) Cadmium 50 mM 48 hrs, 4-day adult  (1024) Cadmium 100 mM 48 hrs, 4-day adult  (811) Copper 0.5 mM 12 hrs, larvae L3  (876) Copper 15 mM 48 hrs, 4-day adult  (303) Zinc 5 mM 12 hrs, larvae L3  (747) Zinc 4.5 mM 48 hrs, 4-day adult  (353) Ethanol 2.5% 3 hrs, larvae L3  (1354) Ethanol 5% 3 hrs, larvae L3  (1293) Ethanol 10% 3 hrs, larvae L3  (1488) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1107) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (848) Caffeine 25 mg/ml 48 hrs, 4-day adult  (548) Paraquat 5 mM 48 hrs, 4-day adult  (933) Paraquat 10 mM 48 hrs, 4-day adult  (1386) Rotenone 2 μg 12 hrs, larvae L3  (1390) Rotenone 8 μg 12 hrs, larvae L3  (1872) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (777) cold shock, 4-day adult  (631) heat shock, 4-day adult  (1505) Cadmium 50 mM 6 hrs, larvae L3  (2236) Cadmium 50 mM 12 hrs, larvae L3  (1296) Cadmium 50 mM 48 hrs, 4-day adult  (1024) Cadmium 100 mM 48 hrs, 4-day adult  (811) Copper 0.5 mM 12 hrs, larvae L3  (876) Copper 15 mM 48 hrs, 4-day adult  (303) Zinc 5 mM 12 hrs, larvae L3  (747) Zinc 4.5 mM 48 hrs, 4-day adult  (353) Ethanol 2.5% 3 hrs, larvae L3  (1354) Ethanol 5% 3 hrs, larvae L3  (1293) Ethanol 10% 3 hrs, larvae L3  (1488) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1107) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (848) Caffeine 25 mg/ml 48 hrs, 4-day adult  (548) Paraquat 5 mM 48 hrs, 4-day adult  (933) Paraquat 10 mM 48 hrs, 4-day adult  (1386) Rotenone 2 μg 12 hrs, larvae L3  (1390) Rotenone 8 μg 12 hrs, larvae L3  (1872) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    777 cold shock, 4-day adult    631 heat shock, 4-day adult    1505 Cadmium 50 mM 6 hrs, larvae L3    2236 Cadmium 50 mM 12 hrs, larvae L3    1296 Cadmium 50 mM 48 hrs, 4-day adult    1024 Cadmium 100 mM 48 hrs, 4-day adult    811 Copper 0.5 mM 12 hrs, larvae L3    876 Copper 15 mM 48 hrs, 4-day adult    303 Zinc 5 mM 12 hrs, larvae L3    747 Zinc 4.5 mM 48 hrs, 4-day adult    353 Ethanol 2.5% 3 hrs, larvae L3    1354 Ethanol 5% 3 hrs, larvae L3    1293 Ethanol 10% 3 hrs, larvae L3    1488 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    848 Caffeine 25 mg/ml 48 hrs, 4-day adult    548 Paraquat 5 mM 48 hrs, 4-day adult    933 Paraquat 10 mM 48 hrs, 4-day adult    1386 Rotenone 2 μg 12 hrs, larvae L3    1390 Rotenone 8 μg 12 hrs, larvae L3    1872 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_22 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010078 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3661-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal RpL23GD13491 lethal, with Scer\GAL4pnr-MD237 RpL23GD13491 Other Phenotypes Allele neuroanatomy defective | larval stage RpL23GD13491 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage RpL23GD13491 ganglion mother cell | larval stage RpL23GD13491
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of RpL23 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL23 Class Mutagen Stocks Known lesion RpL23GD13491 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RpL23KK109066 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpL23NIG.3661R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC863 (Cook and Cook, 2010.2.17, Cook, 2010.2.24) Df(2R)BSC864 (Cook and Cook, 2010.2.17, Cook, 2010.2.24) Df(2R)BSC865 (Cook et al., 2010.2.17, Cook, 2010.2.24)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13491} NA P{KK109066} NA P{NIG.3661R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0023SH0023 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Myo10A (Liu et al., 2008)
Biological Process
CV term Evidence References
mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with Saccharomyces RPL17A (FlyBase, 1992-) non-traceable author statement (Noselli, 1992.9.24, Swiss-Prot Project Members, 1996.2.1)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with Saccharomyces RPL17A (FlyBase, 1992-) non-traceable author statement (Noselli, 1992.9.24)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with Saccharomyces RPL17A (FlyBase, 1992-) non-traceable author statement (Noselli, 1992.9.24) ribosome non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
RpL23 - mthl3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL23 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63240 DroID - A comprehensive database of gene and protein interactions. • FBgn0010078 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37628
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TQMWM Dipteran inclusive ortholog search EOG62NJ8Q Insect inclusive ortholog search EOG63XT13 Arthropod inclusive ortholog search EOG6W6MCJ Metazoa inclusive ortholog search EOG6JMMJX
Orthologs in Drosophila Species (EOG6TQMWM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RpL23     Drosophila simulans   Dsim\GD11716 Y   Drosophila sechellia   Dsec\GM15964 Y   Drosophila erecta   Dere\GG22807 Y   Drosophila yakuba   Dyak\RpL23 Y   Drosophila ananassae   Dana\GF13548 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17595 Y   Drosophila persimilis   Dper\GL10129 Y   Drosophila willistoni   Dwil\GK20786 Y   Drosophila virilis   Dvir\GJ22396 Y   Drosophila mojavensis   Dmoj\GI20545 Y   Drosophila grimshawi   Dgri\GH21796 Y
Orthologs in non-Drosophila Dipterans (EOG62NJ8Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013583   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013097   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015006   Anopheles gambiae Malaria mosquito  Agam\AGAP010252   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011325
Orthologs in non-Dipteran Insects (EOG63XT13)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\RpL23   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005237   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18225   Atta cephalotes Leafcutter ant  Acep\ACEP19507   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21213   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17990   Linepithema humile Argentine ant  Lhum\LH15910   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18964   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000455   Bombyx mori Silkmoth  Bmor\RpL23   Pediculus humanus Human body louse  Phum\PHUM465850   Tribolium castaneum Red flour beetle  Tcas\TC009485
Orthologs in non-Insect Arthropods (EOG6W6MCJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\AP1S2
Orthologs in non-Arthropod Metazoa (EOG6JMMJX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rpl-23   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028226gn   Danio rerio Zebrafish  Drer\rpl23   Xenopus tropicalis Western clawed frog  Xtro\rpl23   Gallus gallus Domestic chicken  Ggal\RPL23   Mus musculus House mouse  Mmus\Rpl23   Rattus norvegicus Norway rat  Rnor\Rpl23   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023076   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005603   Rattus norvegicus Norway rat  Rnor\LOC100362226   Homo sapiens Human  Hsap\RPL23
Human Orthologs (1)
Gene OMIM HGNC Hsap\RPL23
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11716 Drosophila sechellia Dsec\GM15964 Drosophila erecta Dere\GG22807 Drosophila yakuba Dyak\RpL23 Drosophila ananassae Dana\GF13548 Drosophila pseudoobscura pseudoobscura Dpse\GA17595 Drosophila persimilis Dper\GL10129 Drosophila willistoni Dwil\GK20786 Drosophila virilis Dvir\GJ22396 Drosophila mojavensis Dmoj\GI20545 Drosophila grimshawi Dgri\GH21796
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v108402 P{KK109066}VIE-260B v23416 w1118; P{GD13491}v23416 v23418 w1118; P{GD13491}v23418/TM3
Genomic Clones ( 1 )
	BACR09K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 826 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM15762
Other clones	TA01212 yak-em_RpL17A
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17417 AT31174 GH03996 GH05165 GH09095 GH14670 GH16008 GH16122 GH18592 GH28006 GM02213 GM05782 GM08682 GM15350 GM15961 GM17353 GM17832 GM18802 GM21102 GM21212 GM22230 GM22407 GM23795 GM24575 GM24776 GM25882 GM30292 GM30392 GM31718 GM32602 LP01349 LP04164 LP04190 LP05748 LP18317 LP18569 RE26038 RH13332 RH13432 RH13644 RH14010 RH14418 RH14756 RH14878 RH14948 RH15038 RH15665 RH16137 RH16508 RH16685 RH17581 RH18269 RH18281 RH37309 RH38436 RH38815 RH39022 RH40866 RH41476 RH43205 RH43367 RH43655 RH44442 RH44504 RH45135 RH45230 RH45294 RH45801 RH46629 RH46731 RH46757 RH47009 RH47213 RH47527 RH47885 RH48185 RH48228 RH48528 RH50166 RH50882 RH51072 RH51207 RH51477 RH52484 RH52702 RH53269 RH53750 RH55046 RH55719 RH56280 RH56605 RH56753 RH57147 RH57154 RH58765 RH58875 RH58901 RH58975 RH59024 RH59069 RH59378 RH61003 RH63782 RH63938 RH63988 RH64067 RH64226 RH64338 RH64702 RH64954 RH65955 RH66139 RH66331 RH67016 RH67469 RH67609 RH67715 RH68079 RH68435 RH68484 RH68606 RH68756 RH68946 SD07666 SD11295 SD11896 SD12292 SD13339 SD15103 SD15608 SD15670 SD15680 SD16826 SD17442 SD18980 SD21828 SD21918 SD22294 SD23466 SD23578 SD23827 SD25255 SD25677 SD27413
Other clones	20073 21418 39920 75283 78258 78409 97278 99482 109008 147313 147515 149541 161892 177452 522534 522594 522870 523477 524108 524360 524462 524766 524866 525003 525019 527284 542575 542690 542752 542873 557719 558002 558078 561969 562010 575684 CK01.13B.E7 Dmel_dig_000960_0606_0504 Dmel_dig_001449_0640_1626 Dmel_dig_001645_0680_2841 Dmel_dig_002395_0662_0522 Dmel_dig_004085_0658_3533 Dmel_dig_005816_0632_1408 Dmel_dig_006025_0653_2381 Dmel_dig_006182_0662_2334 Dmel_dig_006587_0632_3343 Dmel_dig_006663_0700_1015 Dmel_dig_009588_0703_1477 Dmel_dig_010506_0707_3298 Dmel_dig_010665_0591_1696 Dmel_dig_010758_0671_2407 Dmel_dig_011459_0695_0546 Dmel_dig_013525_0636_1235 Dmel_dig_015033_0599_1484 Dmel_dig_015932_0694_1373 Dmel_dig_016931_0593_1256 Dmel_dig_017115_0626_1892 Dmel_dig_018453_0602_1266 Dmel_dig_020282_0641_1288 Dmel_neb_003174_0120_3718 Dmel_neb_007173_0670_3061 Dmel_neb_008976_0572_1483 Dmel_neb_011148_0080_2286 Dmel_neb_011598_0097_0430 Dmel_neb_011643_0604_1888 Dmel_neb_012532_0910_2821 Dmel_neb_012731_0867_2684 Dmel_neb_012829_0651_3061 Dmel_neb_013103_0681_3432 Dmel_neb_013444_0380_0693 Dmel_neb_013700_0170_1870 Dmel_neb_013937_0329_0886 Dmel_neb_014622_0329_2034 EC25001 EC26219 EC29280 EC31163 EC34661 EC37162 EC37219 EC37682 EC39016 EK014220 EK033108 EK111306 EK127806 EK152303 EK153449 EK163607 EK196709 EK207933 EK211545 EK222047 EK235652 EK268644 EK268709 EK271907 EK273441 EK282730 EN02321 EN02422 EN02803 EN02934 EN03962 EN04759 EN05235 EN05303 EN05435 EN05862 EN06052 EN06332 EN06349 EN07627 EN10863 EN11123 EN11207 EN11242 EN11527 EN12250 EN12813 EN12942 EN13451 EN13537 EN17648 ESG011d.E7.1_B04 ESG011d.E21_B04 ESG0117b.B21_E08 ESG0119b.B21_G02 ESG0120c.B21_C06 ESG0120d.B21_D12 FGA009H12 FGC001C03 FGC006A09 FGC019A02 FGC025B12 FGC030A06 FGH101B07 FGH101H04 FGH103A11 FGH108C04 FGH114E04 FGH115F08 FGH115G12 FGH123B07 FGM103F04 FGM104B03 FGM104B12 FGM105G01 FGM207B10 FGM207D09 FGM207F10 FGM207G12 FGM209D12 FGM212F02 FGM213C03 FGM214C03 FGM215E11 FGM217E03 FGM221F03 FGM227C06 FGM228G08 FGM229A03 FGM231H12 FGM232C05 FGM237A11 FGM315H07 FGM323G06 FGX001E03 GH03104 GH03116 GH06255 GH08105 GH11204 GH11640 GH16509 GH17857 GH21083 GH21115 GH21473 GH21575 GH25537 IP02016 IP02404 IP06014 IP06214 IP11079 IP13838 IP14456 IP14756 IP18386 LD42051 LP05851 LP06169 LP06181 LP10561 LP16166 LP21882 RE04795 RE06128 RE08981 RE09514 RE10184 RE12093 RE12343 RE13277 RE13634 RE14292 RE16617 RE17902 RE19131 RE19512 RE20407 RE23218 RE24564 RE24666 RE24740 RE25021 RE25054 RE25243 RE26536 RE29081 RE31026 RE31032 RE31457 RE33516 RE35763 RE36704 RE36980 RE37490 RE39174 RE39315 RE39391 RE42077 RE42570 RE42651 RE44131 RE44139 RE44676 RE44778 RE45835 RE46029 RE46141 RE46411 RE47479 RE48473 RE48495 RE48736 RE49254 RE49288 RE49468 RE49728 RE50636 RE51154 RE51188 RE51368 RE52233 RE52437 RE52459 RE53230 RE53256 RE54442 RE54476 RE54507 RE54880 RE55113 RE55543 RE55638 RE57259 RE57505 RE58403 RE59207 RE60049 RE60214 RE60328 RE60745 RE61691 RE63161 RE63226 RE63264 RE64020 RE64168 RE65380 RE67742 RE67906 RE68402 RE69413 RE69567 RE69667 RE71214 RE71340 RE71436 RE71513 RE71568 RE71668 RE74368 RH01086 RH01231 RH01317 RH01440 RH01510 RH02022 RH02159 RH02493 RH02708 RH02791 RH02873 RH03030 RH03118 RH03323 RH03425 RH03565 RH03588 RH03642 RH03786 RH03967 RH04074 RH04802 RH05619 RH06013 RH06076 RH06136 RH06306 RH06448 RH06458 RH06705 RH07161 RH07231 RH07334 RH07423 RH07569 RH08234 RH08261 RH08275 RH08444 RH08463 RH08625 RH08782 RH08969 RH09187 RH09307 RH09439 RH09510 RH09745 RH09867 RH09890 RH09968 RH09977 RH10113 RH10164 RH10194 RH10310 RH10715 RH10765 RH10782 RH10846 RH11033 RH11170 RH11265 RH11337 RH11425 RH11447 RH11856 RH12020 RH12754 RH13091 RH13216 RH13278 RH14027 RH14063 RH14282 RH14489 RH14773 RH14886 RH15083 RH15220 RH15317 RH15858 RH15910 RH15965 RH15993 RH17977 RH18346 RH18391 RH20482 RH20544 RH21043 RH21254 RH21594 RH21685 RH22160 RH22270 RH22916 RH23135 RH23141 RH23358 RH23737 RH24380 RH24394 RH24781 RH24814 RH24879 RH24894 RH25670 RH25854 RH25928 RH26040 RH26380 RH26467 RH26843 RH26864 RH27150 RH27224 RH27251 RH27305 RH27782 RH28059 RH28086 RH28195 RH28304 RH28329 RH28364 RH28365 RH28555 RH28578 RH28726 RH28749 RH28872 RH29296 RH29901 RH29971 RH30140 RH30330 RH30682 RH30828 RH30847 RH30962 RH31131 RH31543 RH31593 RH32083 RH32288 RH32674 RH32696 RH32878 RH32940 RH33183 RH33224 RH33252 RH33285 RH33650 RH33727 RH33737 RH33894 RH33977 RH34126 RH34227 RH34280 RH34281 RH34901 RH35795 RH36994 RH37277 RH37680 RH37681 RH37956 RH38025 RH38248 RH38288 RH38342 RH38344 RH38760 RH38874 RH38974 RH39154 RH39302 RH39353 RH39520 RH39601 RH39658 RH40065 RH40089 RH40131 RH40247 RH40392 RH40645 RH41550 RH41727 RH41845 RH42313 RH42531 RH42940 RH42951 RH43171 RH43387 RH43544 RH43836 RH44160 RH44408 RH44514 RH44944 RH45181 RH45371 RH45469 RH45987 RH46028 RH46267 RH46613 RH46844 RH47038 RH47780 RH48326 RH48559 RH48639 RH49273 RH49480 RH50292 RH50488 RH50840 RH50847 RH50973 RH51754 RH51789 RH52648 RH52717 RH52748 RH52889 RH52979 RH52992 RH53491 RH53744 RH53990 RH54362 RH54630 RH54694 RH54929 RH55067 RH56030 RH56539 RH56862 RH57271 RH57625 RH58033 RH58350 RH59139 RH59535 RH60536 RH61445 RH61742 RH61808 RH61904 RH62011 RH62357 RH62467 RH62517 RH62588 RH63167 RH63357 RH63414 RH64042 RH64272 RH64911 RH65140 RH65935 RH66028 RH66051 RH67058 RH67088 RH67544 RH67581 RH67915 RH68177 RH68230 RH68658 RH68769 RH68771 RH69133 RH69632 RH70005 RH70029 RH70053 RH70054 RH70163 RH70223 RH70282 RH70344 RH70354 RH70736 RH70784 RH70981 RH71121 RH71367 RH71523 RH71593 RH71833 RH73358 RH73906 RH73916 RH74107 RH74172 RH74190 RH74266 RH74564 RH74654 RH74670 RH74688 RP003007323 RP003018047 RP003022220 RP003034929 RP003036372 RP003037796 RP003038831 RP003045452 RP003051285 RP003051649 RP003057893 RP003100921 RP003101449 RP003106726 RP003122244 RP003122250 RP003131369 RP003140678 RP003141792 RP003154866 RP003155200 RP003200379 RP003205526 RP003209027 RP003221456 RP003222778 RP003224394 RP003233026 RP003241484 RP003271663 RP003303911 RP003330343 RP003347897 RP003372368 RP003410326 RP003437468 RP003439121 RP003458965 RP003464484 RP003481546 RP003485033 RP003488335 RP003498403 RP003498772 RP003508012 RP003519456 RP003522356 RP003533513 RP003535043 RP003552105 RP003552883 RP003564679 RP003568153 RP003571963 RP003573782 RP003574811 RP003585592 RP003586756 RP003587791 RP003588320 RP003590440 RP003591422 RP003604592 RP003605237 RP003610027 RP003629686 RP003642566 RP003656862 RP003659893 RP003662160 RP003666281 RP003671454 RP003675009 RP003676353
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010078 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37628
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	"RpL17A" may correspond to "M(2)58F".
Other Comments
	Haploinsufficient locus. (Cook et al., 2012) Likely Minute gene. (Cook, 2010.2.24) Deletions removing RpL23 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Cook, 2010.2.24) RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) The 58F6--59A3 region to which RpL17 maps also includes M(2)58F. (Noselli and Vincent, 1992) Homologue of human and yeast large subunit ribosomal protein L17A. The D.melanogaster and yeast genes have different intron/exon structures. (Noselli and Vincent, 1992) Homologue of human and yeast large subunit ribosomal protein L17A.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079089 RefSeq (Proteins) • NP_523813 DDBJ / EMBL / GenBank • AAA28867 AAF46914 BI588185 M85295 Entrez Gene - A searchable database of RefSeq genes. • 37628 UniProtKB/Swiss-Prot • P48159
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L14b/L23e (IPR000218) Ribosomal protein L14 conserved site (IPR019972) Ribosomal protein L14 domain (IPR023571)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63240 DroID - A comprehensive database of gene and protein interactions. • FBgn0010078 DRSC - Results from RNAi screens. • FBgn0010078 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010078 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3661-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010078 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37628 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37628 modMine - Data generated by the modENCODE project. • FBgn0010078
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG3661 (Chandonia and Cohen, 2003, Goshima et al., 2007, Keleman et al., 2009.8.5, Marygold et al., 2007, Cammarato et al., 2011) L17 (Brogna et al., 2002) L23 (Carpenter et al., 2009) RL17 (Mushegian et al., 1998) RpL17A (Boutros et al., 2004, ) Rpl17A (Grauso et al., 2002) RPL17A (Noselli, 1992.9.24) RpL23 (Liu et al., 2008, Goshima et al., 2007, Nie et al., 2009, Marygold et al., 2007, Cook and Cook, 2010.2.17, Cook et al., 2010.2.17, Cook and Cook, 2010.2.17, Cook, 2010.2.24, Neumüller et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Cook et al., 2012, Killip and Grewal, 2012)
Name Synonym	Ribosomal protein L17A   Ribosomal protein L23 (Ashburner and Marygold, 2004.7.2, Liu et al., 2008, Cammarato et al., 2011) ribosomal protein L23 (Mack et al., 2006)
Secondary FlyBase IDs
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Cook et al., 2012, Genome Biol. 13(3): R21 The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. [FBrf0219066] Killip and Grewal, 2012, Dev. Biol. 371(2): 191--202 DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway. [FBrf0219592] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...