γ-tubulin, γ tubulin, γ-Tub, γtubulin, gamma-tubulin
microtubule nucleating factor - eggs produced by mutant mothers show an arrest of nuclear divisions during early embryogenesis and a disruption in the anterior-posterior axis - required for mRNA localization
Gene model reviewed during 5.45
Interacts with Ote.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\γTub37C using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\γTub37C in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Eight independent occurrences recovered by Wright, four more by Schupbach.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Phenotypic rescue of fs(2)TW1 mutants by a γTub37C construct demonstrates γTub37C and fs(2)TW1 are the same gene. This conclusion is substantiated further by the perfect agreement between the restriction maps.
Expression of γTub37C is under strict developmental regulation and the organisation of the female meiotic spindle requires γTub37C. γTub37C gene product provides a function which is essential exclusively for female fertility.
Maternal effect mutant that affects early embryogenesis.
Subcellular localisation of the protein during the cell cycle of cells with and without centrioles is determined. Data suggests centrioles are not essential to the formation of a functional mitotic spindle, but participate in the focal concentration of γTub23C and γTub37C protein during both interphase and mitosis.
Located between coordinates +50.1 and +60.1.
Mutations in γTub37C show a maternal effect with defects in fertilisation or very early embryonic development.
Identification: Saturation mutagenesis of Df(2L)TW130.