FB2020_06, released Dec 22, 2020

Gene: Dmel\mAcon1

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General Information
Symbol
Dmel\mAcon1
Species
D. melanogaster
Name
Mitochondrial aconitase 1
Annotation Symbol
CG9244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010100
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Snapshot
Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As

Acon, Aconitase, mitochondrial aconitase, m-aconitase, ACON-1

Key Links
Genomic Location
Cytogenetic map
39A7-39A7
Sequence location
2L:21,168,570..21,173,185 [+]
Recombination map

2-54

RefSeq locus
NT_033779 REGION:21168570..21173185
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables 4 iron, 4 sulfur cluster binding
inferred from biological aspect of ancestor with PANTHER:PTN000186533
(assigned by GO_Central )
(Gaudet et al., 2011)
enables aconitate hydratase activity
non-traceable author statement
(Zou et al., 2000)
inferred from sequence or structural similarity with UniProtKB:Q99798
(Sardiello et al., 2003.6.11)
inferred from biological aspect of ancestor with PANTHER:PTN000186533
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in tricarboxylic acid cycle
inferred from mutant phenotype
(Cheng et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in tricarboxylic acid cycle
inferred from biological aspect of ancestor with PANTHER:PTN000186533
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Esposito et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN001705783
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000186534
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:Q99798
(Sardiello et al., 2003.6.11)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ACONITASES -
Aconitases are tricarboxylic-acid cycle enzymes that catalyze the stereo-specific isomerization of citrate to isocitrate via cis-aconitate. (Adapted from FBrf0221188).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\mAcon1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mAcon1-RB
FBtr0081473
NM_079969
2732
787
mAcon1-RD
FBtr0300425
NM_001169559
2854
787
mAcon1-RE
FBtr0343871
NM_001103716
3022
787
mAcon1-RF
FBtr0346587
NM_001299190
3102
787
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
mAcon1-PB
FBpp0081002
85.4
787
8.36
NP_524708
AAF53973
mAcon1-PD
FBpp0289654
85.4
787
8.36
NP_001163030
ACZ94316
mAcon1-PE
FBpp0310408
85.4
787
8.36
NP_001097186
ABV53697
mAcon1-PF
FBpp0312178
85.4
787
8.36
NP_001286119
AHN54633
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

787 aa isoforms: mAcon1-PB, mAcon1-PD, mAcon1-PE, mAcon1-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mAcon1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Esposito et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mAcon1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mAcon1
Transgenic constructs containing regulatory region of mAcon1
Deletions and Duplications ( 12 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ACO2
14 of 15
Yes
Yes
Hsap\IREB2
3 of 15
No
No
1  
Hsap\ACO1
2 of 15
No
No
3  
Hsap\CFTR
1 of 15
No
No
10  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aco2
15 of 15
Yes
Yes
Mmus\Ireb2
3 of 15
No
No
Mmus\Aco1
2 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Aco2
13 of 13
Yes
Yes
Rnor\Ireb2
3 of 13
No
No
Rnor\Aco1
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\aco2
9 of 12
Yes
Yes
Xtro\aco1
2 of 12
No
No
Xtro\ireb2
2 of 12
No
No
Danio rerio (Zebrafish) (3)
Drer\aco2
10 of 15
Yes
Yes
Drer\aco1
2 of 15
No
No
Drer\ireb2
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\aco-2
15 of 15
Yes
Yes
Cele\aco-1
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\ACO1
2 of 9
Yes
No
Atha\ACO2
2 of 9
Yes
No
Atha\ACO3
2 of 9
Yes
No
Atha\AT5G54950
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\ACO1
14 of 15
Yes
Yes
Scer\ACO2
7 of 15
No
Yes
Scer\LYS4
3 of 15
No
Yes
Scer\LEU1
2 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPAC24C9.06c
11 of 12
Yes
Yes
Spom\SPBP4H10.15
5 of 12
No
Yes
Spom\leu2
1 of 12
No
Yes
Spom\lys2
1 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902OY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001067
Drosophila simulans
Dsim\GD24307
Drosophila sechellia
Dsec\GM23397
Drosophila erecta
Dere\GG21286
Drosophila yakuba
Dyak\GE12902
Drosophila ananassae
Dana\GF14743
Drosophila pseudoobscura pseudoobscura
Dpse\GA21639
Drosophila persimilis
Dper\GL25895
Drosophila willistoni
Dwil\GK21115
Drosophila virilis
Dvir\GJ17812
Drosophila mojavensis
Dmoj\GI21890
Drosophila grimshawi
Dgri\GH11260
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501ID )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018292
Glossina morsitans
Tsetse fly
Gmor\GMOY003934
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06584
Mayetiola destructor
Hessian fly
Mdes\Mdes018046
Mayetiola destructor
Hessian fly
Mdes\Mdes013127
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003734
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012897
Anopheles darlingi
American malaria mosquito
Adar\ADAC002869
Anopheles gambiae
Malaria mosquito
Agam\AGAP007852
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01B7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007121
Danaus plexippus
Monarch butterfly
Dple\DPOGS210806-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007830
Apis florea
Little honeybee
Aflo\2286123316
Apis mellifera
Western honey bee
Amel\LOC408446
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12792
Bombus terrestris
Buff-tailed bumblebee
Bter\15209146
Linepithema humile
Argentine ant
Lhum\LH19462
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001de2
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000897
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12719
Tribolium castaneum
Red flour beetle
Tcas\TC005725
Pediculus humanus
Human body louse
Phum\PHUM303350
Rhodnius prolixus
Kissing bug
Rpro\RPRC012271
Cimex lectularius
Bed bug
Clec\CLEC001293
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010059
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11287
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0197 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014097
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68484.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g01190
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306094
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G024R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aco2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aco2_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008967
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023796
Gallus gallus
Domestic chicken
Ggal\ACO2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
mAcon2
8 of 10
Irp-1A
4 of 10
Irp-1B
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
mAcon1GD1348
model of  infantile cerebellar-retinal degeneration
CEA
(Cheng et al., 2013)
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
ACO2; aconitase 2
model of  optic atrophy 9
IEA
(FlyBase, 2019-)
model of  infantile cerebellar-retinal degeneration
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACO2; aconitase 2
14 of 15
100850
IREB2; iron responsive element binding protein 2
3 of 15
147582
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    mAcon1 - ATPsynB
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - ATPsynCF6
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - ATPsynD
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - ATPsynF
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - ATPsynO
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Act79B
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Act88F
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Actn
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Adh
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Ald1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Argk
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - CG34172
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - CG5177
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - CG7920
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Cyt-c-p
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Cyt-c1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Eno
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Gdh
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Gpdh1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Gpo1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - GstS1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Mdh2
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Mf
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Mhc
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Mlc1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Mlc2
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Mpcp1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - ND-18
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - ND-PDSW
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Nc73EF
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Prm
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Scp1
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - Tm2
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - TpnC4
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - TpnC41C
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - fln
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - kdn
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - stumps
    two hybrid
    (Battersby et al., 2003)
    mAcon1 - up
    experimental knowledge based
    (Guruharsha et al., 2011)
    mAcon1 - wupA
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ND-19
    suppressible
    mAcon1
    (Esposito et al., 2013)
    Pink1
    suppressible
    mAcon1
    (Esposito et al., 2013)
    Pink1
    suppressible
    mAcon1|Drp1
    (Esposito et al., 2013)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map

    2-54

    Cytogenetic map
    39A7-39A7
    Sequence location
    2L:21,168,570..21,173,185 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    39A7-39A7
    Limits computationally determined from genome sequence between P{lacW}l(2)k07215k07215&P{lacW}snRNA:U4:39Bk09410 and P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    39B1-39B2
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    39A6-39A7
    39B1--2
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-54

    (FlyBase, 2016)

    2-54.5

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (19)
    cDNA Clones (315)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: mAcon1 Acon

      (FlyBase, 2009-)
      Source for database merge of

      Source for merge of: Acon l(2)07054

      (Carpenter, 1999.2.23)

      Source for merge of: Acon BEST:GH10550

      (Rana, 2004.7.8)

      Source for merge of: Acon CG9244

      (FlyBase, 1996-)
      Additional comments

      Renamed from 'Acon' (Aconitase) to 'mAcon1' (Mitochondrial aconitase 1) to reflect that this is a mitochondrial, rather than cytoplasmic, aconitase. This is consistent with the nomenclature used for this gene/protein from several publications. Added a '1' suffix to distinguish it from the other, less studied mitochondrial aconitase (CG4706/mAcon2) that is mainly expressed in the testis (see FBrf0221188).

      (FlyBase, 2009-)

      The CG4706 gene may be derived from the Acon gene by retroposition.

      (Betran et al., 2002)

      Source for merge of Acon CG9244 was sequence comparison ( date:000608 ).

      (FlyBase, 1996-)
      Other Comments

      ChEST reveals this is a target of Mef2.

      (Junion et al., 2005)

      Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

      (Roch et al., 1998)

      No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.

      (Stoltenberg et al., 1992)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 62 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (24)
      Reported As
      Symbol Synonym
      ACON-1
      (Riebler et al., 2008, Choudhary et al., 1992)
      Acon
      (Hudry et al., 2019, Levis, 2018.8.30, Park et al., 2018, Hsu and Drummond-Barbosa, 2017, Transgenic RNAi Project members, 2017-, Aradska et al., 2015, Dent et al., 2015, Foriel et al., 2015, Navarro et al., 2015, DeSalvo et al., 2014, Lavington et al., 2014, Mukherjee et al., 2014, Tricoire et al., 2014, Cheng et al., 2013, Esposito et al., 2013, Lim et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mandilaras and Missirlis, 2012, McGurk and Bonini, 2012, Friedman et al., 2011, Wasbrough et al., 2010, Dworkin et al., 2009, Tan et al., 2009, Dorus et al., 2008, Buszczak et al., 2007, Christensen et al., 2007.10.29, Domanitskaya et al., 2007, Langille and Clark, 2007, Langille and Clark, 2007, Phillips, 2007.12.21, Stuart et al., 2007, Beller et al., 2006, Dorus et al., 2006, Jordan et al., 2006, Terhzaz et al., 2006)
      AconM
      (Spradling et al., 1999)
      BEST:GH10550
      CG9244
      (Rosa-Ferreira et al., 2015, Volkenhoff et al., 2015, Christis and Munro, 2012, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Thornton et al., 2010, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Lindsay et al., 2008, Cermelli et al., 2006, Terhzaz et al., 2006, Battersby et al., 2003, Das et al., 2001)
      M-Acon
      (Anderson et al., 2005)
      acon
      (Chandra et al., 2015, Kanda et al., 2011)
      aconitase
      (Pareek et al., 2018)
      hsp60
      (Alonso et al., 2005)
      i204
      (Battersby et al., 2003)
      i59
      (Battersby et al., 2003)
      l(2)07054
      m-Acon
      (Sun et al., 2012)
      m-acon
      (Missirlis et al., 2003)
      mACON
      (Kirby et al., 2008)
      mAc
      (Lind, 1999.12.21)
      mAcon
      (Cogni et al., 2015, Wicks et al., 2009)
      mAcon1
      Name Synonyms
      ACONITASE
      (Alonso et al., 2005)
      Aconitase
      (Feng et al., 2015, Zhang et al., 2013, McGurk and Bonini, 2012, Wu et al., 2012, Cammarato et al., 2011, Celotto et al., 2011, Robinson et al., 2010, Tan et al., 2009, Curtis et al., 2007, Llorens et al., 2007, Paul et al., 2007, Fergestad et al., 2006, Jordan et al., 2006)
      Mitochondrial aconitase 1
      aconitase
      (Bayliak et al., 2020, Lozinsky et al., 2013, Qin et al., 2013, Sen et al., 2013, Bayat et al., 2012, Kanda et al., 2011, Sun et al., 2011, Cermelli et al., 2006, Alonso et al., 2005, Zou et al., 2000)
      m-Aconitase
      (Cheng et al., 2013, Kirby et al., 2002)
      m-aconitase
      (Wan et al., 2020, Tian et al., 2014)
      mitochondrial aconitase
      (Mandilaras and Missirlis, 2012, Wicks et al., 2009, Anderson et al., 2005, Lind, 1999.12.21)
      Secondary FlyBase IDs
      • FBgn0010634
      • FBgn0032927
      • FBgn0043824
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (138)