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Gene Dmel\comm

General Information
Symbol	Dmel\comm	Species	D. melanogaster
Name	commissureless	Annotation symbol	CG17943
Feature type	protein_coding_gene	FlyBase ID	FBgn0010105
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	71F2-71F2	Sequence location	3L:15,714,611..15,721,530 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene commissureless is referred to in FlyBase by the symbol Dmel\comm (CG17943, FBgn0010105). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: WW domain binding; protein binding. There is experimental evidence that it is involved in the biological process: synapse assembly; receptor internalization; positive regulation of receptor internalization; axon guidance; dendrite morphogenesis; axon midline choice point recognition; neuron recognition; dendrite guidance. 93 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; embryonic/larval neuron; thoracic segment; non-connected developing system; portion of tissue; peripheral nervous system; adult segment; cell part; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1636089_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of comm. Gene sequence location is 3L:15714611..15721530.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 71F2-71F2   Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
Experimentally Determined Cytological Location
Cytogenetic map Notes References 71E3-71E5   (determined by in situ hybridisation)   (Seeger, 1995.7.6)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\comm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) comm-RA FBtr0075579  NM_079371   1678   370 comm-RB FBtr0333023  NM_001274962   2495   370
Additional Transcript Data & Comments
Reported size (kB)	1.7, 1.0 (northern blot) (Tear et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein comm-PA   FBpp0075332   40.3   370   5.04     NP_524095   AAF49584 comm-PB   FBpp0305237   40.3   370   5.04     NP_001261891   AGB94584
Additional Polypeptide Data & Comments
Reported size (kDa)	370 (aa); 40 (kD predicted) (Tear et al., 1996)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49584   AE014296 AGB94584   BI162781   BI163774   BI212266   BI214069   BI215013   BI234643   BI239188   BI240408   BI357364   BI357649   BI358525   BI362351   BI368790   BI369612   BI484996   BI570071   BI589963   BI612564   BI624989   BT031163   BT122139   CK135751   CO185333   CO187647   CO277754   CO281313   CO284089   CO293396   CO294981   CO297600   CO304112   CO304413   CO306683   CO311963   CO321385   CO326160   CO331047   CZ473966   DN154364   EC057707   EC064838   EC069134   EC076413   EC079046   EC085312   EC086595   EC087696   EC087740   EC088201   EC194402   EC200532   EC205045   EC221403   EC222195   EC224626   EC237161   EC246262   U35854 AAC47019
UniProtKB/Swiss-Prot	Q24139
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi hindgut anlage in statu nascendi   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 5   organism | pair rule expression pattern   (Tear et al., 1996) embryonic stage 6 -- 10   organism | segment polarity expression pattern   (Tear et al., 1996) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal ectoderm   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal ectoderm   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 10   epidermis   (Tear et al., 1996) neuroblast   (Tear et al., 1996) ganglion mother cell   (Tear et al., 1996) embryonic stage 10 -- 17   presumptive embryonic/larval central nervous system | presumptive   (Tear et al., 1996) embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium dorsal epidermis primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 12   visceral mesoderm   (Tear et al., 1996) embryonic stage 12 -- 16   ventral midline | restricted   (Tear et al., 1996) midline glial cell   (Tear et al., 1996) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut interstitial cell   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
	The 1.0kb comm transcripts are less abundant than the 1.7kb transcripts and differ only in the site of polyadenylation. (Tear et al., 1996) comm expression is first observed during the cellular blastoderm stage in a pattern of six pair-rule stripes. Stripe 3 is initially missing but subsequently appears. By stage 6, the stripes narrow and interstripes appear forming a pattern of 14 stripes which persist until stage 10. At this time expression is seen in two longitudinal stripes located just lateral to the neurogenic region and extending the length of the segmented embryo. A segmentally repeated pattern is also observed in the emerging CNS. comm is expressed in a subset of neuroblasts and in some ganglion mother cells. By stage 12, expression is observed in the midline of the CNS and in the visceral mesoderm. Along the midline, expression becomes restricted to a subset of cells located at the anterior part of each neuromere. There is also transient expression in neurons just lateral to the midline cells including RP1 and RP3. Double labeling experiments show that these cells lie along the path that the first commissural axons take to reach the midline. From their position, they are thought to be the anterior two pairs of midline glia. comm expression ceases in stage 16. (Tear et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuron   • axon (Tear et al., 1996) ventral nerve cord commissure   (Tear et al., 1996) embryonic stage 5   organism | pair rule expression pattern   (Tear et al., 1996) embryonic stage 6 -- 10   organism | segment polarity expression pattern   (Tear et al., 1996) embryonic stage 10   neuroblast   (Tear et al., 1996) ganglion mother cell   (Tear et al., 1996) epidermis | striped   (Tear et al., 1996) Comment:longitudinal stripes embryonic stage 10 -- 17   presumptive embryonic/larval central nervous system | presumptive   (Tear et al., 1996) embryonic stage 12 -- 16   visceral mesoderm   (Tear et al., 1996) midline glial cell   (Tear et al., 1996) ventral midline | restricted   (Tear et al., 1996)
Additional Descriptive Data
	comm protein appears to accumulate predominantly within intracellular vesicles with a low level present on the plasma membrane. The comm protein likely cycles from the Golgi to the cell surface where some of it is endocytosed. (Tear et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
endocytic vesicle inferred from direct assay (Ing et al., 2007) Golgi apparatus inferred from direct assay (Tear et al., 1996) plasma membrane inferred from direct assay (Tear et al., 1996, Ing et al., 2007) inferred from direct assay (assigned by UniProtKB) (Myat et al., 2002) vesicle inferred from direct assay (Myat et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop    768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop  (768.9) Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop    768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop    768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop    768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop  768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop    768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    162.325 Larval Midgut    37.1 Larval Hindgut    140.9 Larval Malpighian Tubules    201.6 Larval Fat Body    20.5 Larval Salivary Gland    341.8 Larval Trachea    65.075 Larval Carcass    59.625 Adult Head    125.6 Adult Eye    173.4 Adult Brain    186.2 Adult Thoracic-Abdominal Ganglion    143.9 Adult Crop    768.9 Adult Midgut    45.2 Adult Hindgut    246.9 Adult Malpighian Tubules    60.1 Adult Fat Body    61.5 Adult Salivary Gland    389.6 Adult Heart    90.6 Adult VirginFemale Spermatheca    64.4 Adult InseminatedFemale Spermatheca    47.8 Adult Ovary    5.3 Adult Testis    18.6 Adult Male Accessory Gland    47.1 Adult Carcass    73.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    125.6   NA  Eye    173.4   NA  Brain    186.2   162.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    143.9   NA  Crop    768.9   37.1  Midgut    45.2   140.9  Hindgut    246.9   201.6  Malpighian Tubules    60.1   no informative data  Fat Body    61.5   341.8  Salivary Gland    389.6   NA  Heart    90.6   65.075  Trachea    NA   NA  VirginFemale Spermatheca    64.4   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    5.3   NA  Testis    18.6   NA  Male Accessory Gland    47.1   59.625  Carcass    73.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    18 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    32 embryo 04-06hr    85 embryo 06-08hr    71 embryo 08-10hr    67 embryo 10-12hr    53 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr  (32) embryo 04-06hr  (85) embryo 06-08hr  (71) embryo 08-10hr  (67) embryo 10-12hr  (53) embryo 12-14hr  (36) embryo 14-16hr  (33) embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    32 embryo 04-06hr    85 embryo 06-08hr    71 embryo 08-10hr    67 embryo 10-12hr    53 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    32 embryo 04-06hr    85 embryo 06-08hr    71 embryo 08-10hr    67 embryo 10-12hr    53 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    32 embryo 04-06hr    85 embryo 06-08hr    71 embryo 08-10hr    67 embryo 10-12hr    53 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr  32 embryo 04-06hr  (85) embryo 06-08hr  (71) embryo 08-10hr  (67) embryo 10-12hr  (53) embryo 12-14hr  (36) embryo 14-16hr  (33) embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    32 embryo 04-06hr    85 embryo 06-08hr    71 embryo 08-10hr    67 embryo 10-12hr    53 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    32 embryo 04-06hr    85 embryo 06-08hr    71 embryo 08-10hr    67 embryo 10-12hr    53 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    8 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    10 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    6 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8    28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8  (28) wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8    28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8    28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8    28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8  28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8    28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    10 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    17 leg disc CME L1    12 wing disc CME-W2    11 wing disc ML-DmD8    28 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RH64772 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17943-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for comm Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal commMI00380 lethal | larval stage comm3 comm5 lethal | recessive comm1 comm2 comm4 comm6 comm7 comm8 viable, with Scer\GAL4pnr-MD237 commGD2477 Other Phenotypes Allele neuroanatomy defective comm1 comm5 commdsRNA.cIa commE39 communspecified neuroanatomy defective, with Scer\GAL448Y commEP neuroanatomy defective, with Scer\GAL4A307 commScer\UAS.cKa neuroanatomy defective, with Scer\GAL4ap-md52 commScer\UAS.cKa neuroanatomy defective, with Scer\GAL4eg-Mz360 commdsRNA.HP.Scer\UAS neuroanatomy defective, with Scer\GAL4elav.PLu commdsRNA.HP.Scer\UAS commL229A.Scer\UAS.T:Hsap\MYC commP230A.Scer\UAS.T:Hsap\MYC commS231A.Scer\UAS.T:Hsap\MYC commS231A.Y232A.Scer\UAS.T:Hsap\MYC commScer\UAS.T:Hsap\MYC commY232A.Scer\UAS.T:Hsap\MYC commΔ176-370.Scer\UAS.T:Hsap\MYC neuroanatomy defective, with Scer\GAL4elav-C155 commScer\UAS.cWa commΔPSY.Scer\UAS.T:Hsap\MYC neuroanatomy defective, with Scer\GAL4eve.CQ2 commScer\UAS.cKa neuroanatomy defective, with Scer\GAL4unspecified commdsRNA.HP.Scer\UAS commScer\UAS.T:Avic\GFP-m6 commΔ1.Scer\UAS.T:Avic\GFP-m6 commΔ2.Scer\UAS.T:Avic\GFP-m6 neuroanatomy defective (with comm1) comm5 neuroanatomy defective (with comm5) comm1 neuroanatomy defective | cell autonomous comm5 neuroanatomy defective | embryonic stage 16 comm072 commΔe39 neuroanatomy defective | embryonic stage 16, with Scer\GAL4ap-md544 commKR.Scer\UAS.T:Ivir\HA1 commScer\UAS.T:Hsap\MYC commΔ2-36.Scer\UAS.T:Hsap\MYC commΔ2-58.Scer\UAS.T:Hsap\MYC commΔ2-98.Scer\UAS.T:Hsap\MYC commΔ35-108.Scer\UAS.T:Hsap\MYC commΔ57-108.Scer\UAS.T:Hsap\MYC commΔ91-108.Scer\UAS.T:Hsap\MYC commΔ108-131.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a commΔ132-160.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a neuroanatomy defective | embryonic stage 16, with Scer\GAL4elav.PLu commScer\UAS.T:Hsap\MYC neuroanatomy defective | embryonic stage, with Scer\GAL415J2 commScer\UAS.cUa neuroanatomy defective | recessive comm1 comm5 uncoordinated comm1 comm2 comm4 comm6 comm7 comm8 Phenotype manifest in Allele abdominal segmental nerve comm1 comm5 abdominal segmental nerve, with Scer\GAL4how-24B commΔC.Scer\UAS aCC neuron comm5 antennal commissure, with Scer\GAL4SG18.1 commScer\UAS.cKa antennal lobe glomerulus, with Scer\GAL4SG18.1 commScer\UAS.cKa anterior commissure comm1 anterior commissure, with Scer\GAL4elav-C155 commΔPSY.Scer\UAS.T:Hsap\MYC commScer\UAS.cWa axon | cell autonomous comm5 chordotonal organ & embryo & nerve terminal, with Scer\GAL412.1 commScer\UAS.cKa commissure comm1 comm3 comm4 comm5 comm7 comm8 commB204 commE39 communspecified commissure, with Scer\GAL4elav.PLu commdsRNA.HP.Scer\UAS commissure, with Scer\GAL4unspecified commdsRNA.HP.Scer\UAS commissure | embryonic stage communspecified connective comm5 dendrite, with Scer\GAL4eve.CQ2 commScer\UAS.cKa dMP2 neuron, with Scer\GAL415J2 commScer\UAS.cUa dorsal branch | third instar larval stage, with Scer\GAL4btl.PS commScer\UAS.T:Hsap\MYC embryonic/larval neuron communspecified embryonic/larval neuron, with Scer\GAL4eg-Mz360 commdsRNA.HP.Scer\UAS embryonic/larval neuron, with Scer\GAL4sca-537.4 commScer\UAS.cKa embryonic ventral nervous system, with Scer\GAL4ap-md52 commScer\UAS.cKa ganglionic branch primordium communspecified ganglionic branch primordium, with Scer\GAL4btl.PS commScer\UAS.cKa giant fiber neuron, with Scer\GAL4A307 commScer\UAS.cKa intersegmental nerve comm1 comm5 intersegmental nerve, with Scer\GAL4how-24B commΔC.Scer\UAS longitudinal connective comm8 communspecified longitudinal connective, with Scer\GAL4elav.PLu commdsRNA.HP.Scer\UAS commL229A.Scer\UAS.T:Hsap\MYC commP230A.Scer\UAS.T:Hsap\MYC commS231A.Y232A.Scer\UAS.T:Hsap\MYC longitudinal connective, with Scer\GAL4unspecified commdsRNA.HP.Scer\UAS longitudinal connective | embryonic stage 16 commΔe39 longitudinal connective | embryonic stage 16, with Scer\GAL4ap-md544 commScer\UAS.T:Hsap\MYC commΔ2-36.Scer\UAS.T:Hsap\MYC commΔ2-58.Scer\UAS.T:Hsap\MYC commΔ2-98.Scer\UAS.T:Hsap\MYC commΔ35-108.Scer\UAS.T:Hsap\MYC commΔ57-108.Scer\UAS.T:Hsap\MYC commΔ91-108.Scer\UAS.T:Hsap\MYC commΔ108-131.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a commΔ132-160.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a commKR.Scer\UAS.T:Ivir\HA1 longitudinal connective | embryonic stage 16, with Scer\GAL4elav.PLu commScer\UAS.T:Hsap\MYC mesothoracic dorsal triscolopidial chordotonal organ dch3, with Scer\GAL448Y commEP metathoracic dorsal triscolopidial chordotonal organ dch3, with Scer\GAL448Y commEP midline crossing tract, with Scer\GAL4ap-md544 commΔ91-108.Scer\UAS.T:Hsap\MYC commΔ132-160.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a midline crossing tract | embryonic stage 16 commΔe39 comm072 midline crossing tract | embryonic stage 16, with Scer\GAL4ap-md544 commScer\UAS.T:Hsap\MYC commΔ2-36.Scer\UAS.T:Hsap\MYC commΔ2-58.Scer\UAS.T:Hsap\MYC commΔ2-98.Scer\UAS.T:Hsap\MYC commΔ35-108.Scer\UAS.T:Hsap\MYC commΔ57-108.Scer\UAS.T:Hsap\MYC commΔ108-131.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a commKR.Scer\UAS.T:Ivir\HA1 midline crossing tract | embryonic stage 16, with Scer\GAL4elav.PLu commScer\UAS.T:Hsap\MYC midline glial cell commΔe39 comm1 motor neuron, with Scer\GAL4eve.CQ2 commScer\UAS.cKa neuroblast NB3-1 | cell autonomous comm5 neuroblast NB5-6 | cell autonomous comm5 pCC neuron, with Scer\GAL4sca-537.4 commScer\UAS.cKa posterior commissure comm1 posterior commissure, with Scer\GAL4elav-C155 commΔPSY.Scer\UAS.T:Hsap\MYC commScer\UAS.cWa presumptive embryonic/larval central nervous system commΔe39 commB204 presumptive embryonic/larval central nervous system, with Scer\GAL4sca-537.4 commScer\UAS.cKa presumptive embryonic/larval central nervous system, with Scer\GAL4unspecified commΔ1.Scer\UAS.T:Avic\GFP-m6 commΔ2.Scer\UAS.T:Avic\GFP-m6 commScer\UAS.T:Avic\GFP-m6 RP2 motor neuron comm5 RP3 motor neuron comm5 tritocerebral commissure comm1 ventral anastomosis 0 comm1 ventral anastomosis 1 comm1 ventral anastomosis 2 comm1 ventral nerve cord comm1 ventral nerve cord, with Scer\GAL4elav-C155 commΔPSY.Scer\UAS.T:Hsap\MYC commScer\UAS.cWa ventral nerve cord commissure commΔe39 comm1 comm5 comm8 commE39 commdsRNA.cIa ventral nerve cord commissure & larval brain | somatic clone comm1 comm5 V neuron comm5
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of comm Class Mutagen Stocks Known lesion commd04506 P-element activity 1 -- commEY10154 1 -- commMI00380-BM.1 site specific recombinase 1 Yes commMI00380-mCh.1 site specific recombinase 1 Yes commMI00380 1 Yes commMI04589 1 -- comm3 amorphic allele - genetic evidence X ray 0 Yes comm5 loss of function allele, amorphic allele - genetic evidence P-element activity 0 Yes comm072 0 Yes comm1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes comm2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- comm4 hypomorphic allele - genetic evidence X ray 0 Yes comm6 hypomorphic allele - genetic evidence P-element activity 0 -- comm7 hypomorphic allele - genetic evidence P-element activity 0 -- comm8 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- commB204 ethyl methanesulfonate 0 -- commE39 loss of function allele 0 Yes commEP 0 -- commMI00380-DV.1 site specific recombinase 0 Yes commMI00380-GFSTF.1 site specific recombinase 0 Yes commMI00380-HS.1 site specific recombinase 0 Yes commMI00380-KV.1 site specific recombinase 0 Yes commMI00380-TRH.1 site specific recombinase 0 Yes communspecified loss of function allele 0 -- commΔe39 loss of function allele 0 --
Alleles Carried on Transgenic Constructs ( 68 )
For All Alleles Carried on Transgenic Constructs Show
Allele of comm Class Mutagen Stocks Known lesion commGD2477 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes commJF03018 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes comm2PY.AY.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commAct5C.PT in vitro construct - regulatory fusion 0 Yes commAct5C.T:Zzzz\HPC4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commDEAL-AAAA.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commdsRNA.cIa in vitro construct - RNAi 0 Yes commdsRNA.HP.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes commIC.MtnA.T:Mmus\Cd8a,T:Avic\GFP-m6 in vitro construct - coding region fusion 0 Yes commIC.MtnA.T:Uuuu\Myr5,T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commIC.Scer\UAS.T:Mmus\Cd8a,T:Avic\GFP-m6 in vitro construct - coding region fusion 0 Yes commIC.Scer\UAS.T:Uuuu\Myr5,T:Avic\GFP-m6 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes commKK103866 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes commKR.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commKR.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes commL229A.P230A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commL229A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commMtnA.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commNIG.17943R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes commP230A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commPCYT-AAAA.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commS231A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commS231A.Y232A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes commScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes commScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes commScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes commScer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes commsim.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commsli.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commT:Avic\GFP-S65T in vitro construct - coding region fusion 0 Yes commT:Hsap\MYC in vitro construct - coding region fusion 0 Yes commY232A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commYPSL-AAAA.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes commΔ1.MtnA.T:Avic\GFP-m6 in vitro construct - deletion 0 Yes commΔ1.Scer\UAS.T:Avic\GFP-m6 in vitro construct - deletion 0 Yes commΔ108-131.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes commΔ132-160.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a in vitro construct - amino acid replacement in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ176-199.245-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-199.258-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-199.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-219.245-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-219.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-244.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-257.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ176-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ2-36.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ2-58.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ2-98.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ2.MtnA.T:Avic\GFP-m6 in vitro construct - deletion 0 Yes commΔ2.Scer\UAS.T:Avic\GFP-m6 in vitro construct - deletion 0 Yes commΔ220-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ245-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ258-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ266-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ293-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ2PY.MtnA.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ2PY.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ319-370.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes commΔ35-108.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ57-108.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔ91-108.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes commΔEC.MtnA.T:Avic\GFP-m6 in vitro construct - deletion 0 Yes commΔEC.Scer\UAS.T:Avic\GFP-m6 in vitro construct - deletion 0 Yes commΔPSY.MtnA.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes commΔPSY.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Ab(3;?)comm4 (Tear et al., 1996) Df(3L)BK10 (Tear et al., 1996) Df(3L)comm-X4 (Seeger et al., 1993) Df(3L)fz-M21 (Seeger, 1995.7.6, Tear et al., 1996) Tp(3;3)comm3 (Tear et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2477} NA P{KK103866} NA P{NIG.17943R} NA P{TRiP.JF03018} NA P{UAS-comm.CD8.IC} NA P{UAS-comm.DEAL->AAAA} NA P{UAS-comm.GFP} NA P{UAS-comm.K} NA P{UAS-comm.KR.HA} NA P{UAS-comm.L229A.P230A} NA P{UAS-comm.L229A} NA P{UAS-comm.MYC} NA P{UAS-comm.myr.IC} NA P{UAS-comm.P230A} NA P{UAS-comm.PCYT->AAAA} NA P{UAS-comm.R} NA P{UAS-comm.S231A.Y232A} NA P{UAS-comm.S231A} NA P{UAS-comm.U} NA P{UAS-comm.W} NA P{UAS-comm.Y232A} NA P{UAS-comm.YPSL->AAAA} NA P{UAS-comm.Δ1} NA P{UAS-comm.Δ2-36.MYC} NA P{UAS-comm.Δ2-58.MYC} NA P{UAS-comm.Δ2-98.MYC} NA P{UAS-comm.Δ2} NA P{UAS-comm.Δ2PY} NA P{UAS-comm.Δ35-108.MYC} NA P{UAS-comm.Δ57-108.MYC} NA P{UAS-comm.Δ91-108.MYC} NA P{UAS-comm.Δ108-131.MYC.CD8} NA P{UAS-comm.Δ132-160.MYC.CD8} NA P{UAS-comm.Δ176-199.245-370} NA P{UAS-comm.Δ176-199.258-370} NA P{UAS-comm.Δ176-199} NA P{UAS-comm.Δ176-219.245-370} NA P{UAS-comm.Δ176-219} NA P{UAS-comm.Δ176-244} NA P{UAS-comm.Δ176-257} NA P{UAS-comm.Δ176-370} NA P{UAS-comm.Δ220-370} NA P{UAS-comm.Δ245-370} NA P{UAS-comm.Δ258-370} NA P{UAS-comm.Δ266-370} NA P{UAS-comm.Δ293-370} NA P{UAS-comm.Δ319-370} NA P{UAS-comm.ΔC} NA P{UAS-comm.ΔEC} NA P{UAS-comm.ΔPSY} NA P{UAS-comm-dsRNA.HP} NA characterization construct P{sim-comm.MYC} NA P{sli-comm.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}commEP NA P{EPgy2}commEY10154 NA P{XP}commd04506 NA miscellaneous insertions Mi{MIC}commMI00380 NA Mi{MIC}commMI04589 NA Mi{PT-BM.1}commMI00380-BM.1 NA Mi{PT-DV.1}commMI00380-DV.1 NA Mi{PT-GFSTF.1}commMI00380-GFSTF.1 NA Mi{PT-HS.1}commMI00380-HS.1 NA Mi{PT-KV.1}commMI00380-KV.1 NA Mi{PT-mCh.1}commMI00380-mCh.1 NA Mi{PT-TRH.1}commMI00380-TRH.1 NA P{Khc.KA}comm6 NA insertion of enhancer trap binary system P{GalW}ND14 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Nedd4 (Ing et al., 2007) inferred from physical interaction with UniProtKB:Q9VVI3 (assigned by UniProtKB) (Myat et al., 2002) WW domain binding inferred from direct assay (Kanelis et al., 2006) inferred from physical interaction with Nedd4 (Myat et al., 2002)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with fra (Yang et al., 2009) inferred from mutant phenotype (Myat et al., 2002, Kidd et al., 1999, Hiramoto and Hiromi, 2006) axon midline choice point recognition inferred from mutant phenotype (Simionato et al., 2007) inferred from mutant phenotype (assigned by UniProtKB) (Myat et al., 2002) NOT axon midline choice point recognition inferred from mutant phenotype (Keleman et al., 2005) dendrite guidance inferred from mutant phenotype (Furrer et al., 2003) dendrite morphogenesis inferred from mutant phenotype (Mauss et al., 2009) neuron recognition inferred from mutant phenotype (Zlatic et al., 2003) positive regulation of receptor internalization inferred from mutant phenotype (Myat et al., 2002) receptor internalization inferred from direct assay (assigned by UniProtKB) (Myat et al., 2002) synapse assembly inferred from mutant phenotype (Ing et al., 2007)
Cellular Component
CV term Evidence References
endocytic vesicle inferred from direct assay (Ing et al., 2007) Golgi apparatus inferred from direct assay (Tear et al., 1996) plasma membrane inferred from direct assay (Tear et al., 1996, Ing et al., 2007) inferred from direct assay (assigned by UniProtKB) (Myat et al., 2002) vesicle inferred from direct assay (Myat et al., 2002)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) traceable author statement (Narayanan and Ramaswami, 2001, Grueber and Jan, 2004) axon midline choice point recognition traceable author statement (Chiba, 1999) dendrite morphogenesis traceable author statement (Grueber and Jan, 2004) endocytosis traceable author statement (Narayanan and Ramaswami, 2001) nervous system development traceable author statement (Hidalgo, 2002) synapse assembly traceable author statement (Narayanan and Ramaswami, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions comm allele Gene References comm1 ena (Bashaw et al., 2000) comm5 Ptp10D (Sun et al., 2000) commScer\UAS.cWa Nedd4 (Myat et al., 2002) commΔe39 robo (Simpson et al., 2000) unspecified Ptp69D (Sun et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65032 DroID - A comprehensive database of gene and protein interactions. • FBgn0010105 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39717
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X983G Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6X983G)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\comm     Drosophila simulans   Dsim\GD12538 Y   Drosophila sechellia   Dsec\GM24465 Y   Drosophila erecta   Dere\GG13521 Y   Drosophila yakuba   Dyak\GE19813 Y   Drosophila ananassae   Dana\GF10376 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14736 Y   Drosophila persimilis   Dper\GL25475 Y   Drosophila willistoni   Dwil\GK20663 Y   Drosophila virilis   Dvir\GJ13957 Y   Drosophila mojavensis   Dmoj\GI13621 Y   Drosophila grimshawi   Dgri\GH14475 Y   Drosophila grimshawi   Dgri\GH10044
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12538 Drosophila sechellia Dsec\GM24465 Drosophila erecta Dere\GG13521 Drosophila yakuba Dyak\GE19813 Drosophila ananassae Dana\GF10376 Drosophila pseudoobscura pseudoobscura Dpse\GA14736 Drosophila persimilis Dper\GL25475 Drosophila willistoni Dwil\GK20663 Drosophila virilis Dvir\GJ13957 Drosophila mojavensis Dmoj\GI13621 Drosophila grimshawi Dgri\GH14475
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	28381 y1 v1; P{TRiP.JF03018}attP2/TM3, Sb1 30977 y1 w*; Mi{MIC}commMI00380/TM6B, Tb1 39658 y1 w*; Mi{PT-BM.1}commMI00380-BM.1/TM6B, Tb1 39659 y1 w*; Mi{PT-mCh.1}commMI00380-mCh.1/TM6B, Tb1 37827 y1 w*; Mi{MIC}commMI04589/TM3, Sb1 Ser1 17644 y1 w67c23; P{EPgy2}commEY10154/TM3, Sb1 Ser1
Harvard	- P{XP}commd04506
VDRC	v5277 w1118; P{GD2477}v5277 v5278 w1118; P{GD2477}v5278
Genomic Clones ( 1 )
	BACR20J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE60050
Other clones	FI11937
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE02011 RE03273 RE17324 RE19772 RE21193 RE30379 RE35613 RE37249 RE43831 RE44179 RE45312 RE46888 RE54829 RE55848 RE68209 RH02319 RH03495 RH41481
Other clones	15892 39576 52983 60144 61952 72134 78659 101851 102426 104111 106751 108092 194096 194234 CK01.4A.E11 CK01.36B.D12 CK01.41C.C10 EK008220 EK031036 EK126228 EK156434 EK165221 EK170151 EK185561 EK202831 EK208111 EK225759 EK227524 EK243749 EK244631 EK251903 EK297342 EP03339 RH64772
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010105 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39717
Antibody Information
	polyclonal (Tear et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The absence of elav affects neuronal expression of comm. (Simionato et al., 2007) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) comm acts as a sorting receptor for robo, diverting it from synthetic to the late endocytic pathway. comm seems to be required in the commissural neurons not in midline cells for midline crossing. (Keleman et al., 2002) The intracellular region of comm is essential for the downregulation of robo. comm redistributes robo away from the cell surface. robo and comm form a stable complex in S2 cells. comm is a specific binding partner and substrate of Nedd4. (Myat et al., 2002) Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) comm downregulates robo expression. (Kidd et al., 1998) comm controls growth cone guidance across the CNS midline and encodes a novel membrane protein. As commissural growth cones contact and traverse the CNS midline, the comm protein is apparently transferred from midline glia to commissural axons. (Tear et al., 1996) The comm gene product is required for commissural growth cones to bypass a general repulsive system operating at the midline. In the absence of comm commissural growth cones that are attracted to the midline by other mechanisms are unable to cross and ultimately retract their commissural projections. (Seeger et al., 1995) The comm gene product plays a role in the attractive signalling system, a component of the mechanism that guides growth cones towards and away from the midline. In mutant embryos the growth cones of commissural neurons do not project across the midline, but extend only on their own side of the central nervous system (CNS). (Goodman et al., 1993) Mutant alleles show absent commissural axon pathways in the embryonic ventral nerve cord. (Seeger et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079371 NM_001274962 RefSeq (Proteins) • NP_524095 NP_001261891 DDBJ / EMBL / GenBank • AAC47019 AAF49584 AGB94584 BI624989 CZ473966 U35854 Entrez Gene - A searchable database of RefSeq genes. • 39717 UniProtKB/Swiss-Prot • Q24139
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH64772
Linkouts
	BioGRID - A database of protein and genetic interactions • 65032 DroID - A comprehensive database of gene and protein interactions. • FBgn0010105 DRSC - Results from RNAi screens. • FBgn0010105 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17943-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010105 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39717 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/commirs1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39717 modMine - Data generated by the modENCODE project. • FBgn0010105
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG17943 (Hadar et al., 2012, Perkins et al., 2009, Keleman et al., 2009.8.5) comm (Chen et al., 2007, Venken et al., 2011, Venken et al., 2011, Hadar et al., 2012, Hsouna et al., 2003, Murphey and Godenschwege, 2002, Furrer et al., 2003, Hiramoto and Hiromi, 2006, Keleman et al., 2005, Bhat et al., 2007, Couch and Condron, 2002, Ing et al., 2007, Simionato et al., 2007, Myat et al., 2002, Southall and Brand, 2009, Ou et al., 2008, Furrer et al., 2007, Gilestro, 2008, Yang et al., 2009, Zlatic et al., 2009, Mauss et al., 2009, Magalhaes et al., 2007, Buffin and Gho, 2010, Evans et al., 2010, Coleman et al., 2010, Smibert et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Comm (Chilton, 2006, Jowdy and Seeger, 2008, Murphey and Godenschwege, 2002, Kanelis et al., 2006, Zhong et al., 2011, Brierley et al., 2009, Schulz et al., 2011, Evans and Bashaw, 2012)
Name Synonym	commissureless (Andrews and Kidd, 2008, Furrer et al., 2003, Hiramoto and Hiromi, 2006, Keleman et al., 2005, Simionato et al., 2007, Zhong et al., 2011, Gilestro, 2008, Yang et al., 2009, Mauss et al., 2009, Buffin and Gho, 2010, Coleman et al., 2010) Commissureless (Chilton, 2006, Jowdy and Seeger, 2008, Murphey and Godenschwege, 2002, Ing et al., 2007, Furrer et al., 2007) Commisureless (Brierley et al., 2009)
Secondary FlyBase IDs
References ( 180 )
Generate a list of	All references relating to this gene ( 180 )
List References by type	Research paper  ( 68 ) Supplementary material  ( 7 ) Review  ( 47 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 36 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Conference report  ( 5 )
Recent research papers ( 8 )
	Evans and Bashaw, 2012, Dev. Biol. 363(1): 266--278 Slit/Robo-mediated axon guidance in Tribolium and Drosophila: Divergent genetic programs build insect nervous systems. [FBrf0217506] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Slováková et al., 2012, J. Neurosci. 32(29): 10035--10044 The Actin-Binding Protein Canoe/AF-6 Forms a Complex with Robo and Is Required for Slit-Robo Signaling during Axon Pathfinding at the CNS Midline. [FBrf0218957] Smibert et al., 2012, Cell Rep. 1(3): 277--289 Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila. [FBrf0218523] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Schulz et al., 2011, EMBO Rep. 12(10): 1039--1046 Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels. [FBrf0216287] Venken et al., 2011, Nat. Methods 8(9): 737--743 MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. [FBrf0216331] Zhong et al., 2011, PLoS ONE 6(11): e27007 A Splice Isoform of DNedd4, DNedd4-Long, Negatively Regulates Neuromuscular Synaptogenesis and Viability in Drosophila. [FBrf0216790] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...