Fusion-6, psg12, l(3)B4-3-20
Gene model reviewed during 5.47
Gene model reviewed during 5.44
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression supported by data in FBrf0216884.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hdc using the Feature Mapper tool.
hdc shows a gradual increase in expression after puparium formation in salivary glands and in whole animals, with a spike in expression immediately after head eversion in salivary glands.
hdc transcripts are observed in the CNS, in imaginal disc primordia, and in imaginal tracheal cells of the spiracular branch.
hdc protein is an extremely basic (pI 9.6), cysteine-rich cytoplasmic protein.
hdc protein is expressed in the cytoplasm of the fusion cells of the dorsal anastomoses in metameres 2-9, the lateral trunk, and ventral anastamoses.
GBrowse - Visual display of RNA-Seq signalsView Dmel\hdc in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: hdc l(3)B4-3-20
hdc is a branching inhibitor produced by specialised tracheal cells to prevent neighbouring cells from branching.
In mutants, cells that are normally quiescent acquire the branching fate and form an increased number of sprouts emanating from the primary branches.
Cellular, molecular and genetic characterisation of hdc, which is required for imaginal cell development. Imaginal disc morphology in null mutants appears normal, so loss of hdc expression does not affect imaginal cell growth but instead interferes with the ability of the imaginal primordia to differentiate properly during pupal development. These results suggest hdc may be involved in hormonal responsiveness during metamorphosis.
Recessive pupal lethal: head structure abnormal.