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Gene Dmel\hig

General Information
Symbol	Dmel\hig	Species	D. melanogaster
Name	hikaru genki	Annotation symbol	CG2040
Feature type	protein_coding_gene	FlyBase ID	FBgn0010114
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	CT6282
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45B7-45B8	Sequence location	2R:5,115,286..5,134,752 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hikaru genki is referred to in FlyBase by the symbol Dmel\hig (CG2040, FBgn0010114). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: cell adhesion. 15 alleles are reported. The phenotype of these alleles is annotated with: central nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Complement control module; Immunoglobulin subtype; Immunoglobulin-like; Immunoglobulin-like fold; Sushi/SCR/CCP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1636585_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of hig. Gene sequence location is 2R:5115286..5134752.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN46210 BKN31121 HFA07628
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45B7-45B8   Limits computationally determined from genome sequence between P{lacW}CG8788k04512&P{lacW}l(2)k13412k13412 and P{PZ}Pkn06736
Experimentally Determined Cytological Location
Cytogenetic map Notes References 45C-45C   (determined by in situ hybridisation)   (Hoshino et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hig for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hig-RA FBtr0088607  NM_165667   4026   958 hig-RB FBtr0088606  NM_165666   3951   933 hig-RC FBtr0088608  NM_080371   4259   866 hig-RD FBtr0100119  NM_001014514   4334   891
Additional Transcript Data & Comments
Reported size (kB)	4.5 (northern blot) (Hoshino et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hig-PA   FBpp0087688   107.0   958   7.75     NP_724773   AAF58960 hig-PB   FBpp0087687   104.2   933   7.39     NP_724772   AAG22296 hig-PC   FBpp0087689   96.7   866   7.52     NP_525110   AAG22297 hig-PD   FBpp0100157   99.6   891   7.89     NP_001014514   AAS64892
Additional Polypeptide Data & Comments
Reported size (kDa)	891 (aa) (Hoshino et al., 1993)
Comments	One of several protein products generated by alternative splicing. (FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sushi/SCR/CCP (IPR000436) Immunoglobulin-like (IPR007110) Immunoglobulin subtype (IPR003599) Complement control module (IPR016060) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567413   AE013599 AAF58960   AE013599 AAG22296   AE013599 AAG22297   AE013599 AAS64892   AI064357   AI108074   AI108149   AI109716   AI109787   AI292856   AI295290   AI389772   AI404330   AI404895   AI405523   AI405770   AI514241   AI517452   AW941855   AY069188 AAL39333   BG632174   BI215859   BI229731   BI238661   BI241342   BI363813   BI363919   BI365376   BI365478   BI371828   BI565598   BI614564   BI630706   BT001427 AAN71182   BT012667   BT125623   CO178734   CO187731   CO196469   CO266492   CO271273   CO271279   CO277782   CO279150   CO279772   CO279775   CO289008   CO290155   CO291841   CO296283   CO304560   CO307796   CO309720   CO322972   CO324250   CO327224   CO327643   CO328287   CO332077   CO342063   CZ477205   CZ478392   CZ487768   CZ487769   D13825   D13864   D13877   D13878   D13879   D13880   D13881   D13882   D13883   D13884 BAA02984   D13885 BAA02985   D13886 BAA02986   D13887 BAA02987   D13888   EC059111   EC061569   EC072705   EC082341   EC090597   EC196411   EC202967   EC217119   EC219810   EC227576   EC237386   EC241764   EC242879   EC244152   EC251508   GH983135   Z70835
UniProtKB/Swiss-Prot	Q09101
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   RP neuron   (Hoshino et al., 1993) embryonic stage | mid -- embryonic stage | late   pCC neuron   (Hoshino et al., 1993) adult stage   head   (Hoshino et al., 1993) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   supraesophageal ganglion   (Hoshino et al., 1993) embryonic stage 10 -- 17   central nervous system | restricted   (Hoshino et al., 1993)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010114    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010114 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010114 expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr    1407 embryo 18-20hr    1983 embryo 20-22hr    1790 embryo 22-24hr    1705 larva L1    1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP    1612 pupae 4d postWPP    1750 adult male 01day    1657 adult male 05day    1980 adult male 30day    2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr  (169) embryo 06-08hr  (287) embryo 08-10hr  (562) embryo 10-12hr  (777) embryo 12-14hr  (547) embryo 14-16hr  (951) embryo 16-18hr  (1407) embryo 18-20hr  (1983) embryo 20-22hr  (1790) embryo 22-24hr  (1705) larva L1  (1610) larva L2  (461) larva L3 12hr old  (167) larva L3 puffstage 1-2  106 larva L3 puffstage 3-6  (129) larva L3 puffstage 7-9  (159) white prepupae new  (206) white prepupae 12hr  (428) white prepupae 24hr  (567) pupae 2d postWPP  (1126) pupae 3d postWPP  (1612) pupae 4d postWPP  (1750) adult male 01day  (1657) adult male 05day  (1980) adult male 30day  (2028) adult female 01day  (832) adult female 05day  (272) adult female 30day  (302) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr  1407 embryo 18-20hr  (1983) embryo 20-22hr  (1790) embryo 22-24hr  (1705) larva L1  (1610) larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP  (1612) pupae 4d postWPP  (1750) adult male 01day  (1657) adult male 05day  (1980) adult male 30day  (2028) adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr    1407 embryo 18-20hr    1983 embryo 20-22hr    1790 embryo 22-24hr    1705 larva L1    1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP    1612 pupae 4d postWPP    1750 adult male 01day    1657 adult male 05day    1980 adult male 30day    2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr    1407 embryo 18-20hr    1983 embryo 20-22hr    1790 embryo 22-24hr    1705 larva L1    1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP    1612 pupae 4d postWPP    1750 adult male 01day    1657 adult male 05day    1980 adult male 30day    2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010114 expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr    1407 embryo 18-20hr    1983 embryo 20-22hr    1790 embryo 22-24hr    1705 larva L1    1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP    1612 pupae 4d postWPP    1750 adult male 01day    1657 adult male 05day    1980 adult male 30day    2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr  (169) embryo 06-08hr  (287) embryo 08-10hr  (562) embryo 10-12hr  (777) embryo 12-14hr  (547) embryo 14-16hr  (951) embryo 16-18hr  (1407) embryo 18-20hr  (1983) embryo 20-22hr  (1790) embryo 22-24hr  (1705) larva L1  (1610) larva L2  (461) larva L3 12hr old  (167) larva L3 puffstage 1-2  106 larva L3 puffstage 3-6  129 larva L3 puffstage 7-9  (159) white prepupae new  (206) white prepupae 12hr  (428) white prepupae 24hr  (567) pupae 2d postWPP  (1126) pupae 3d postWPP  (1612) pupae 4d postWPP  (1750) adult male 01day  (1657) adult male 05day  (1980) adult male 30day  (2028) adult female 01day  (832) adult female 05day  (272) adult female 30day  (302) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr  1407 embryo 18-20hr  1983 embryo 20-22hr  1790 embryo 22-24hr  1705 larva L1  1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP  1612 pupae 4d postWPP  1750 adult male 01day  1657 adult male 05day  1980 adult male 30day  2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr    1407 embryo 18-20hr    1983 embryo 20-22hr    1790 embryo 22-24hr    1705 larva L1    1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP    1612 pupae 4d postWPP    1750 adult male 01day    1657 adult male 05day    1980 adult male 30day    2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    92 embryo 04-06hr    169 embryo 06-08hr    287 embryo 08-10hr    562 embryo 10-12hr    777 embryo 12-14hr    547 embryo 14-16hr    951 embryo 16-18hr    1407 embryo 18-20hr    1983 embryo 20-22hr    1790 embryo 22-24hr    1705 larva L1    1610 larva L2    461 larva L3 12hr old    167 larva L3 puffstage 1-2    106 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    159 white prepupae new    206 white prepupae 12hr    428 white prepupae 24hr    567 pupae 2d postWPP    1126 pupae 3d postWPP    1612 pupae 4d postWPP    1750 adult male 01day    1657 adult male 05day    1980 adult male 30day    2028 adult female 01day    832 adult female 05day    272 adult female 30day    302 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010114    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010114 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010114 expression level Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head    618.2 Adult Eye    235.3 Adult Brain    1854.5 Adult Thoracic-Abdominal Ganglion    2337.5 Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head  (618.2) Adult Eye    235.3 Adult Brain  (1854.5) Adult Thoracic-Abdominal Ganglion  (2337.5) Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head    618.2 Adult Eye    235.3 Adult Brain  (1854.5) Adult Thoracic-Abdominal Ganglion  (2337.5) Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head    618.2 Adult Eye    235.3 Adult Brain    1854.5 Adult Thoracic-Abdominal Ganglion    2337.5 Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010114 expression level Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head    618.2 Adult Eye    235.3 Adult Brain    1854.5 Adult Thoracic-Abdominal Ganglion    2337.5 Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head  618.2 Adult Eye    235.3 Adult Brain  (1854.5) Adult Thoracic-Abdominal Ganglion  (2337.5) Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head    618.2 Adult Eye    235.3 Adult Brain  (1854.5) Adult Thoracic-Abdominal Ganglion  (2337.5) Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    160.925 Larval Midgut    1.8 Larval Hindgut    3.7 Larval Malpighian Tubules    5.1 Larval Fat Body    3.1 Larval Salivary Gland    6.1 Larval Trachea    5.325 Larval Carcass    3.55 Adult Head    618.2 Adult Eye    235.3 Adult Brain    1854.5 Adult Thoracic-Abdominal Ganglion    2337.5 Adult Crop    3.5 Adult Midgut    4.9 Adult Hindgut    3.9 Adult Malpighian Tubules    3.1 Adult Fat Body    7.8 Adult Salivary Gland    7.6 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    0.9 Adult Testis    5.5 Adult Male Accessory Gland    7.4 Adult Carcass    24.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    618.2   NA  Eye    235.3   NA  Brain    1854.5   160.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2337.5   NA  Crop    3.5   1.8  Midgut    4.9   3.7  Hindgut    3.9   5.1  Malpighian Tubules    3.1   3.1  Fat Body    7.8   6.1  Salivary Gland    7.6   NA  Heart    3.35   5.325  Trachea    NA   NA  VirginFemale Spermatheca    3.1   NA  InseminatedFemale Spermatheca    3.8   NA  Ovary    0.9   NA  Testis    5.5   NA  Male Accessory Gland    7.4   3.55  Carcass    24.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010114 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2040-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for hig Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | adult stage higP1 viable higf06695 viable, with Scer\GAL4pnr-MD237 higGD5279 Sterility Allele fertile higf06695 Other Phenotypes Allele behavior defective higdd37 behavior defective | recessive higdd37 flightless higdd37 hypoactive higP1 locomotor behavior defective higP1 uncoordinated | larval stage higdd37 higP1 wild-type higD12.hs Phenotype manifest in Allele central nervous system higdd37
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of hig Class Mutagen Stocks Known lesion higf06695 piggyBac transposase 2 -- higdd37 loss of function allele, amorphic allele - genetic evidence Delta2-3 1 Yes higd10259 1 -- higd10310 P-element activity 1 -- hige00507 piggyBac transposase 1 -- higf05147 piggyBac transposase 1 -- higP1 P-element activity 0 -- higrev1 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hig Class Mutagen Stocks Known lesion higGD5279 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes higJF03013 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes higD12.hs in vitro construct - regulatory fusion 0 Yes higD12.MtnA in vitro construct - regulatory fusion 0 Yes highs.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes higKK111121 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes higScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hsD12} NA P{hs-hig.HA} NA UAS construct P{GD5279} NA P{KK111121} NA P{TRiP.JF03013} NA P{UAS-hig.HA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}hige00507 NA PBac{WH}higf05147 NA PBac{WH}higf06695 NA insertion of enhancer trap P{FZ}higP1 No P{lacW}l(2)SH0336SH0336 No insertion of mobile activating element P{XP}higd10259 NA P{XP}higd10310 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from sequence or structural similarity with EMBL:U39446 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hig allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61786 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010114 DroID - A comprehensive database of gene and protein interactions. • FBgn0010114 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35949
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13090 Dere\GG10570 Dgri\GH20029 Dmoj\GI19207 Dper\GL16901 Dpse\GA15198 Dsec\GM20616 Dsim\GD10090 Dvir\GJ20277 Dwil\GK17970 Dyak\GE22434
Curated drosophilid orthologs	Dpse\GA15198
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004725-PA Aedes aegypti (mosquito) AGAP008538-PA Anopheles gambiae (mosquito) CPIJ008865 Culex pipens (mosquito) 311061 Daphnia pulex (daphnia) PHUM011157-PA Pediculus humanus (human body louse) XP_971621.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17527 NV13293 LH19289 ISCW012094 ISCW004162 FBgn0239657 FBgn0219969 FBgn0207417 FBgn0181865 FBgn0175498 JGI_V11_65279 FBgn0075223 FBgn0154505 FBgn0141946 FBgn0127493 FBgn0102878 FBgn0090123 CPIJ008865 BGIBMGA000593 ACYPI45104 GB12000 AGAP008538 AAEL004725 PHUM581680 GLEAN_03245
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	28376 y1 v1; P{TRiP.JF03013}attP2 19000 w1118; PBac{WH}higf06695 Cyp4p2f06695
Harvard	- P{XP}higd10259 - P{XP}higd10310 - PBac{RB}hige00507 - PBac{WH}higf05147 - PBac{WH}higf06695
Kyoto	109573 w*; higdd37 / CyO
VDRC	v13266 w1118 P{GD5279}v13266
Genomic Clones ( 1 )
	BACR10M14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH15868 GH23986 RE38380
Other clones	DPiM_GH23986 RT02802
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04658 GH04739 GH06803 GH06903 GH08975 GH09136 GH21030 GH24750 GH25546 GH25894 GH27328 GH28406 HL01148 LP08878 RE22614 RE27572 RE35168 RE48761 RE48906 RE50661 RE50806 RE58831 RH43962 RH59990 RH63393
Other clones	19051 28263 35639 117287 118683 178538 214405.56 274625 CK01.72C.C4 CK01.94A.D1 CK01.98C.G7 CK01.110C.D12 CK01.110C.G12 CK01.116A.G3 EK004720 EK032227 EK057442 EK069906 EK073213 EK102736 EK102745 EK126356 EK133639 EK135961 EK136006 EK146562 EK189324 EK193051 EK198513 EK213309 EK218954 EK245115 EK255702 EK302446 EP06505 EP07805 EP08916 EP13735 RP004213220
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010114 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35949
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Phenotypic analysis suggests that hig plays a crucial role in the formation of functional neural circuitry. (Hoshino et al., 1996) hig has a role in the development of CNS functions involved in locomotor activity. The mutant phenotype includes abnormal locomotor behaviour. (Hoshino et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080371 NM_165666 NM_165667 NM_001014514 RefSeq (Proteins) • NP_525110 NP_724772 NP_724773 NP_001014514 DDBJ / EMBL / GenBank • AAF58960 AAF58960.1 AAG22296 AAG22296.1 AAG22297 AAG22297.1 AAL39333 AAN71182 AAS64892 AI292856 AI404330 AW941855 AY069188 BAA02984 BAA02985 BAA02986 BAA02987 BI241342 BT001427 CZ477205 CZ478392 CZ487768 CZ487769 D13825 D13864 D13877 D13878 D13879 D13880 D13881 D13882 D13883 D13884 D13885 D13886 D13887 D13888 Z70835 Entrez Gene - A searchable database of RefSeq genes. • 35949 UniProtKB/Swiss-Prot • Q09101
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sushi/SCR/CCP (IPR000436) Immunoglobulin-like (IPR007110) Immunoglobulin subtype (IPR003599) Complement control module (IPR016060) Immunoglobulin-like fold (IPR013783)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61786 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010114 DroID - A comprehensive database of gene and protein interactions. • FBgn0010114 DRSC - Results from RNAi screens. • FBgn0010114 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010114 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2040-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010114 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35949 InParanoid A subset of ortholog calls from InParanoid. • AAEL004725-PA Aedes aegypti (mosquito) AGAP008538-PA Anopheles gambiae (mosquito) CPIJ008865 Culex pipens (mosquito) 311061 Daphnia pulex (daphnia) PHUM011157-PA Pediculus humanus (human body louse) XP_971621.2 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/hikarug1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35949 modMine - Data generated by the modENCODE project. • FBgn0010114 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17527 NV13293 LH19289 ISCW012094 ISCW004162 FBgn0239657 FBgn0219969 FBgn0207417 FBgn0181865 FBgn0175498 JGI_V11_65279 FBgn0075223 FBgn0154505 FBgn0141946 FBgn0127493 FBgn0102878 FBgn0090123 CPIJ008865 BGIBMGA000593 ACYPI45104 GB12000 AGAP008538 AAEL004725 PHUM581680 GLEAN_03245
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG2040 (Perkins et al., 2009, Keleman et al., 2009.8.5) CT6282 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) HIG (Sone et al., 2005, Halaby and Mornon, 1998, Sone et al., 2007) hig (Sone et al., 2009, Anholt and Williams, 2010)
Name Synonym	hikaru genki (Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Hoshino, 1993, Kurusu et al., 2008) Hikaru genki (Sone et al., 2007)
Secondary FlyBase IDs
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 13 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Anholt and Williams, 2010, Chem. Senses 35(1): 21--30 The soluble proteome of the Drosophila antenna. [FBrf0209552] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...