synaptic protein - IG superfamily - required at during pupariation for the formation of normal neural circuitry - exhibits segregated distribution within synaptic clefts and plays a distinct roles in synaptogenesis - localizes to cholinergic synaptic clefts and regulates postsynaptic organization in the Drosophila brain.
Gene model reviewed during 5.48
4.5 (northern blot)
None of the polypeptides share 100% sequence identity.
One of several protein products generated by alternative splicing.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hig using the Feature Mapper tool.
hig-protein localizes at synaptic clefts of cholinergic neurons in the adult brain.
hig-protein labels the cell bodies of cholinergic neurons and a subset of glutamatergic neurons. But the protein is mainly localized in the synaptic cleft of cholinergic neurons next to the presynaptic active-zone marker brp and juxtaposed with the postsynaptic marker nAChRα7.
GBrowse - Visual display of RNA-Seq signalsView Dmel\hig in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.