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General Information
Symbol
Dmel\Wnt5
Species
D. melanogaster
Name
Wnt oncogene analog 5
Annotation Symbol
CG6407
Feature Type
FlyBase ID
FBgn0010194
Gene Model Status
Stock Availability
Gene Snapshot
Wnt oncogene analog 5 (Wnt5) encodes a member of the Wnt gene family and acts as a signalling ligand for the Ryk family of receptor tyrosine kinase-related Wnt receptors. Among other processes, the product of Wnt5 contributes to repulsive embryonic axon pathfinding, mushroom body growth and antennal lobe patterning. [Date last reviewed: 2018-09-13]
Also Known As
DWnt-3, DWnt5, DWnt3, Wnt3, Dwnt-5
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:18,501,401..18,505,405 [-]
Recombination map
1-60
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Wnt family. (P28466)
Molecular Function (GO)
[Detailed GO annotations]
Summaries
Gene Group (FlyBase)
WNTs -
WNTs are evolutionarily conserved secreted Cys-rich glycoproteins, defined by sequence homology to the original members of the family - Wnt1 in mouse and wingless (wg) in Drosophila. They are extracellular ligands for members of the Frizzled family of receptors as well as other receptors. (Adapted from PMID:23151663).
Protein Function (UniProtKB)
Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May have a role in limb and CNS development; may be a downstream target of Dll that acts in the specification of these primordia.
(UniProt, P28466)
Summary (Interactive Fly)
Wnt superfamily ligand involved in axon guidance and salivary gland morphogenesis - Wnt5 and Derailed gradients pattern the Drosophila olfactory dendritic map.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Wnt5 or the JBrowse view of Dmel\Wnt5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074623
3850
1004
FBtr0343046
4005
1004
Additional Transcript Data and Comments
Reported size (kB)
4.4 (northern blot)
3.8 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074394
112.5
1004
9.02
FBpp0309792
112.5
1004
9.02
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1004 aa isoforms: Wnt5-PA, Wnt5-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
140 (kD observed)
1004 (aa); 112 (kD)
1010 (aa); 113 (kD predicted)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with porcupine (por).
(UniProt, P28466)
Post Translational Modification
Glycosylated, glycosylation is stimulated by porcupine at the ER. Palmitoleoylated by porcupine. The lipid group functions as a sorting signal, targeting the ligand to polarized vesicles that transport Wnt5 to unique sites at the cell surface. Depalmitoleoylated by notum, leading to inhibit Wnt signaling pathway.
(UniProt, P28466)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wnt5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (18 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:Q9VWV9
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
Biological Process (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:drl; FB:FBgn0015380
inferred from genetic interaction with FLYBASE:uzip; FB:FBgn0004055
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
At stage 12, Wnt5 expression is observed in the epidermis, most prominently in two clusters, and throughout the somatic mesoderm that will give rise to the body wall musculature. At early stage 16, Wnt5 is present in the muscle attachment sites, and at low levels in contractile fibers in most muscles, including the A1-7 lateral transverse muscles 1, 2, and 3. At the end of embryonic development at late stage 17, Wnt5 is almost undetectable in the somatic mesoderm.
Wnt5 is predominantly expressed in neuronal cell bodies that do not express drl (are associate with the posterior commissure.
Wnt5 transcript expression pattern was compared to that of MAb44C11, a monoclonal antibody that recognizes nuclei throughout the brain and ventral nerve cord (as well as the PNS) . Wnt5 is found in all the CNS cells that stain with MAb44C11, but not in the PNS cells.
Wnt5 transcripts are distributed ubiquitously throughout the embryo until germ band extension. Then, specific staining can be seen in the nascent limb primordia of the head and thoracic segments and in stripes along the ventral neuroectoderm. Transcription in the limb primordia requires Dll activity.
Wnt5 transcript is detected in all developmental stages. In embryos, it is first detected in the cellular blastoderm stage, at 20-80% egg length. By gastrulation, the presumptive cephalic and ventral furrows express Wnt5 transcript. Mesodermal Wnt2 expression is first detected at stage 6, and continues at least until stage 15. At stages 10-11, the labial, maxillary, antennal and labral segments, and at stage 11, the thoracic leg primordia express Wnt5 transcript. Wnt5 expression in the CNS is detected starting at stage 11, through at least stage 16.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
drl-protein is expressed in six large groups of cells in the dorsomedial part of the third instar larval brain. In the pupal brain drl-protein is detected in cells of the protocerebrum surrounding the mushroom body.
Wnt5-protein is detected at 16h APF throughout the developing antennal lobes with high concentrations in the anterior dorsolateral and posterior ventrolateral regions. Expression is also detected in a developing neuron projection bundle terminating at the dorsolateral edge of the developing adult antennal lobe. Wnt5-protein is co-expressed with Scer\GAL4GH146 and drl-protein in dendrites of a subset of antennal lobe projection neurons.
At stage 12, Wnt5 expression is observed in the epidermis, most prominently in two clusters, and throughout the somatic mesoderm that will give rise to the body wall musculature. At early stage 16, Wnt5 is present in the muscle attachment sites, and at low levels in contractile fibers in most muscles, including the A1-7 lateral transverse muscles 1, 2, and 3. At the end of embryonic development at late stage 17, Wnt5 is almost undetectable in the somatic mesoderm.
Wnt5 protein was localized to projection neuron dendrites during glomerular development.
Wnt5 protein is localized to neuronal cell bodies lateral to the midline of the ventral nerve cord in early embryonic stage 12. At stages embryonic stages 13-16, Wnt5 protein is found on longitudinal axons and on axons of the anterior and posterior commissures, with greatest abundance on the axons of the posterior commissures.
Wnt5 protein expression pattern resembles the Wnt5 transcript expression pattern. At stage 10, expression is detected in bilaterally symmetrical regions corresponding to the labrum and antennal primordia and the labial and maxillary gnathal segments. At stage 11, the protein is found in ventral patches of cells corresponding to the thoracic limb primordia, and in each neuromere. As the germ band retracts, expression is detected in the supraesophageal ganglia of the brain. By stage 13, expression is detected throughout the ventral nerve cord at low levels, with strong staining detected in each hemisegment in a pattern suggestive of the commissural and longitudinal axon bundles. Double staining with MAbBP102, which recognizes all neuronal cells, indicates that Wnt5 protein is expressed in neuronal cells.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: TI{GAL4}Wnt5Gal4
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Wnt5 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Wnt5
Transgenic constructs containing regulatory region of Wnt5
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
axon & dorsal cluster neuron
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
Yes
4 of 15
Yes
No
3 of 15
No
No
3 of 15
Yes
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
Yes
4 of 15
Yes
Yes
3 of 15
No
No
3 of 15
Yes
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
4 of 13
Yes
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (18)
3 of 12
Yes
Yes
3 of 12
Yes
Yes
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (26)
5 of 15
Yes
Yes
3 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
5 of 15
Yes
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (7)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901T7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150814 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05K3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07DR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OFF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
4 of 10
4 of 10
3 of 10
3 of 10
3 of 10
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with porcupine (por).
    (UniProt, P28466 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-60
    Cytogenetic map
    Sequence location
    X:18,501,401..18,505,405 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    17B6-17C1
    Limits computationally determined from genome sequence between P{EP}CG32549EP1317 and P{EP}EP443EP443&P{EP}BxEP1383
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    17A-17B
    (determined by in situ hybridisation)
    17B1-17B2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (8)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (66)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Wnt5 CG6407
    Source for database merge of
    Source for merge of: Wnt5 anon-WO03040301.228
    Additional comments
    "l(1)G0265" may affect "Wnt5".
    Source for merge of Wnt5 anon-WO03040301.228 was sequence comparison ( date:051113 ).
    Other Comments
    Wnt5 originating from the anterior dorsolateral domain of the antennal lobe is required for the migration of projection neuron dendrites during development of the adult antennal lobe. Wnt5 appears to act as a repulsive guidance cue for the projection neuron dendrites.
    drl and Wnt5 are required (in the salivary gland and in the central nervous system respectively) for normal salivary gland migration in the embryo. They are required in the third phase of migration, to mediate the final positioning of the gland, as the salivary gland detaches from the circular visceral mesoderm and contacts the longitudinal visceral mesoderm.
    Wnt5 is an anterograde signal that is expressed by olfactory receptor neurons. It is required to organise the glomerular pattern in the developing antennal lobe.
    Wnt5 has a role in axon guidance as a ligand for drl.
    Wnt5 cannot functionally replace wg in an in vivo assay. Transfection of cell culture with a construct encoding Wnt5 demonstrates Wnt5 to be a secreted protein which is likely to play a role in development of the CNS.
    Wnt3 and Wnt5 are the same gene, and as the sequence is more similar to the vertebrate Wnt-5a and Wnt-5b genes the Wnt5 designation is more appropriate.
    The expression of Wnt5 depends on the activity of Dll.
    Wnt5 encodes an amino terminal signal peptide suggesting the gene product is a secreted protein. The distribution of Wnt5 transcripts in cells of the CNS during embryogenesis suggests Wnt5 plays a role in CNS development.
    Sequence analysis of Wnt genes is performed in several species to determine the ancestral lineage of the gene family.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 56 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (25)
    Reported As
    Symbol Synonym
    anon-WO03040301.228
    wnt3
    Name Synonyms
    Wnt oncogene analog 5
    wnt-oncogene-analog-3
    Secondary FlyBase IDs
    • FBgn0004361
    • FBgn0066822
    Datasets (0)
    Study focus (0)
    Experimental Role
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    References (130)