FlyBase Gene Report: Dmel\Gyc32E

General Information

Symbol

Dmel\Gyc32E

Species

D. melanogaster

Name

Guanylyl cyclase at 32E

Annotation Symbol

CG33114

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010197

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GC, Guanyl cyclase at 32E

Key Links

Genomic Location

Cytogenetic map

32D5-32D5

Sequence location

2L:11,138,759..11,149,101 [-]

Recombination map

2-44

RefSeq locus

NT_033779 REGION:11138759..11149101

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables guanylate cyclase activity

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(FlyBase Curators, 2008--)

non-traceable author statement

(assigned by UniProt )

(Gigliotti et al., 1993)

enables peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(assigned by GO_Central )

(Gaudet et al., 2011)

NOT enables protein kinase activity

inferred from key residues

(Anamika et al., 2009)

enables signaling receptor activity

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(FlyBase Curators, 2008--)

non-traceable author statement

(assigned by UniProt )

(Gigliotti et al., 1993)

Biological Process (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in cGMP biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cGMP-mediated signaling

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(FlyBase Curators, 2008--)

non-traceable author statement

(assigned by UniProt )

(Gigliotti et al., 1993)

involved_in protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in receptor guanylyl cyclase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN001728782

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(FlyBase Curators, 2008--)

non-traceable author statement

(assigned by UniProt )

(Gigliotti et al., 1993)

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001728782

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

RECEPTOR GUANYLATE CYCLASES

PUTATIVE PSEUDOKINASES

Protein Family (UniProt)

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q07553)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RECEPTOR GUANYLATE CYCLASES -: Receptor guanylate cyclases are single-pass transmembrane receptors with an extracellular ligand-binding domain and intracellular guanylate cyclase and pseudokinase kinase domains. Ligand binding results in the activation of the intracellular guanylyl cyclase domain and the production of cyclic GMP from GTP. The kinase domain may have a regulatory role and may bind ATP. (Adapted from FBrf0228387).
PUTATIVE PSEUDOKINASES -: Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gyc32E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Gene model reviewed during 5.40

Single-base exon is postulated.

Gene model reviewed during 5.57

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gyc32E-RB

FBtr0112856

NM_001103678

3844

1191

Gyc32E-RD

FBtr0343625

NM_176013

3760

1163

Gyc32E-RG

FBtr0346610

NM_001298905

3736

1155

Additional Transcript Data and Comments

Reported size (kB)

4.5 (northern blot)

(Gigliotti et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Gyc32E-PB

FBpp0111769

134.3

1191

7.89

NP_001097148

ABV53670

Gyc32E-PD

FBpp0310220

130.9

1163

7.77

NP_788027

AAF53079

Gyc32E-PG

FBpp0312190

129.9

1155

7.54

NP_001285834

AHN54348

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gyc32E using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gyc32E_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis

germarium

(Gigliotti et al., 2000)

oogenesis stage S10

egg chamber

(Gigliotti et al., 2000)

embryonic stage 1

organism | ubiquitous

(Gigliotti et al., 1993)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

germarium

(Gigliotti et al., 1993)

adult stage & oogenesis stage S10

nurse cell

(Gigliotti et al., 1993)

larval stage

(Gigliotti et al., 1993)

adult stage

adult head

(Gigliotti et al., 1993)

Additional Descriptive Data

Weak Gyc32E expression was observed in RNA from larvae and adult heads on northern blots. By in situ hybridization, transcripts are detected in ovaries in germarium regions 2 and 3. They disappear and then reappear at stage S10 in nurse cells. Gyc32E transcripts are uniform in very early embryos. Later they are confined to yolk and are not present in blastoderm cells. They reappear along the germ band of germ band elongated embryos.

(Gigliotti et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gyc32E in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gyc32E

View exonic expression by tissue for Dmel\Gyc32E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010197

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010197

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG33114-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0010197

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gyc32E

Transgenic constructs containing regulatory region of Gyc32E

Deletions and Duplications ( 1 )

Disrupted in

Df(2L)salm^FRT

(Spletter et al., 2015)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (24)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GUCY2F

5 of 15

Yes

Hsap\NPR2

5 of 15

Yes

Hsap\GUCY2C

4 of 15

Yes

4 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (24)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Gucy2f

5 of 15

Yes

Mmus\Gucy2g

5 of 15

Yes

Mmus\Npr2

5 of 15

Yes

Mmus\Gucy2c

4 of 15

Yes

4 of 15

4 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (21)

Rnor\Gucy2g

5 of 13

Yes

Rnor\Npr2

5 of 13

Yes

Rnor\Gucy2c

4 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (18)

Xtro\gucy2c

4 of 12

Yes

Xtro\gucy2d

4 of 12

Yes

Xtro\gucy2f

4 of 12

Yes

Xtro\npr1

4 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\LOC101732945

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (31)

Drer\gucy2g

5 of 15

Yes

Drer\npr1a

5 of 15

Yes

Drer\npr1b

5 of 15

Yes

Drer\gc2

4 of 15

Drer\gucy2c

4 of 15

Yes

Drer\gucy2d

4 of 15

Drer\gucy2f

4 of 15

Drer\si:ch73-139e5.4

4 of 15

Yes

4 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\npr2

2 of 15

Drer\si:ch211-132f19.7

2 of 15

Drer\si:dkey-206f10.1

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\gcy-12

7 of 15

Yes

Cele\gcy-15

6 of 15

Yes

Cele\gcy-21

6 of 15

Yes

Cele\gcy-17

5 of 15

Yes

Cele\gcy-22

5 of 15

Yes

Cele\gcy-4

4 of 15

Yes

Cele\gcy-6

4 of 15

Yes

Cele\gcy-7

4 of 15

Yes

Cele\gcy-11

4 of 15

Yes

Cele\gcy-20

4 of 15

Yes

Cele\gcy-28

4 of 15

Cele\gcy-2

3 of 15

Yes

Cele\gcy-3

3 of 15

Yes

Cele\gcy-9

3 of 15

Yes

Cele\gcy-13

3 of 15

Yes

Cele\gcy-14

3 of 15

Yes

Cele\gcy-27

3 of 15

Yes

Cele\odr-1

3 of 15

Yes

Cele\gcy-1

2 of 15

Yes

Cele\gcy-5

2 of 15

Cele\gcy-19

2 of 15

Yes

Cele\gcy-25

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (2)

Atha\CRLK2

1 of 9

Yes

Atha\GLR5

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CDC15

1 of 15

Yes

Scer\CYR1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900WT )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA25709

Drosophila persimilis

Dper\GL18585

Drosophila willistoni

Dwil\GK15240

Drosophila virilis

Dvir\GJ14934

Drosophila mojavensis

Dmoj\GI18149

Drosophila grimshawi

Dgri\GH10964

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500J9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17019158

Glossina morsitans

Tsetse fly

Gmor\GMOY006072

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07586

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005330

Anopheles darlingi

American malaria mosquito

Adar\ADAC001359

Anopheles darlingi

American malaria mosquito

Adar\ADAC001364

Anopheles gambiae

Malaria mosquito

Agam\AGAP008848

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009261

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00YE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06885

Tribolium castaneum

Red flour beetle

Tcas\TC033927

Pediculus humanus

Human body louse

Phum\PHUM591960

Rhodnius prolixus

Kissing bug

Rpro\RPRC005633

Cimex lectularius

Bed bug

Clec\CLEC005794

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05064

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02B4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW020214

Tetranychus urticae

Two-spotted spider mite

Turt\tetur14g00180

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_62171

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_39825

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02QS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1_7

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-NprA_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-NprA

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Guanc

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SpnprA

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007738gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ints3_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Npr1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ints3

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000002537

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008690

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007273

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000001143

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000029097

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027630

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027046

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (27)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

4 of 10

4 of 10

3 of 10

3 of 10

Ac3

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

rut

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

NPR2; natriuretic peptide receptor 2

model of Miura type epiphyseal chondrodysplasia

IEA

(FlyBase, 2019-)

model of acromesomelic dysplasia, Maroteaux type

IEA

(FlyBase, 2019-)

GUCY2C; guanylate cyclase 2C

model of congenital diarrhea 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GUCY2F; guanylate cyclase 2F, retinal

5 of 15

300041

NPR2; natriuretic peptide receptor 2

5 of 15

108961

GUCY2C; guanylate cyclase 2C

4 of 15

601330

congenital diarrhea 6

NPR1; natriuretic peptide receptor 1

4 of 15

108960

GUCY2D; guanylate cyclase 2D, retinal

3 of 15

600179

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010197

MIST (protein-protein) - An integrated Molecular Interaction Database

Gyc32E

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Purine metabolism

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-44

Cytogenetic map

32D5-32D5

Sequence location

2L:11,138,759..11,149,101 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

32D5-32D5

Limits computationally determined from genome sequence between P{lacW}RfC38^k13807 and P{PZ}l(2)04008⁰⁴⁰⁰⁸&P{PZ}cmet⁰⁴⁴³¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-44

(FlyBase, 2016)

2-37.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Bloomington

34120

y¹ w^*; Mi{MIC}Gyc32E^MI00914

40785

y¹ w^*; Mi{MIC}Gyc32E^MI05545

54528

y¹ w^*; Mi{MIC}Gyc32E^MI10319

55503

y¹ w^*; Mi{MIC}Gyc32E^MI10556

14137

y¹ w^67c23; P{SUPor-P}Gyc32E^KG06014

65330

y¹ w^*; Mi{PT-GFSTF.0}Gyc32E^{MI05545-GFSTF.0}

81160

y¹ w^*; TI{CRIMIC.TG4.0}Gyc32E^{CR01046-TG4.0}

VDRC

v330384

P{VSH330384}attP40

v108142

P{KK106110}VIE-260B

v342606

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02450}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010197

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34553

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Gyc32E CG6275

(Gong, 1999.11)

Source for database merge of

Additional comments

Annotation CG6275 split into CG33114 (Gyc32E) and CG31867 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Preliminary experiments using a P element-borne copy of the wild type Gyc32E 12kb genomic region failed to rescue either abo¹ or l(2)gd1¹ phenotypes.

(Gigliotti et al., 1993)

Identified as the first transcription unit downstream of the blood insertion in abo¹.

(Gigliotti et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34553

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.