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Gene Dmel\α-Cat

General Information
Symbol	Dmel\α-Cat	Species	D. melanogaster
Name	α Catenin	Annotation symbol	CG17947
Feature type	protein_coding_gene	FlyBase ID	FBgn0010215
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	αcat, Dα-cat, alpha-Cat, a-cat
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	80F1-80F2	Sequence location	3L:23,311,774..23,331,205 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α Catenin is referred to in FlyBase by the symbol Dmel\α-Cat (CG17947, FBgn0010215). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding; cytoskeletal protein binding. Based on sequence similarity, it is predicted to be involved in the biological process: cytoskeletal anchoring at plasma membrane. 11 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha-catenin; Vinculin, conserved site; Vinculin/alpha-catenin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632724_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alpha-Cat. Gene sequence location is 3L:23311774..23331205.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA11917 BKN27916 BKN46135 References Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Controlled Vocabulary Terms medulla lamina pupal stage P7
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 80F1-80F2   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 80B-80B   (determined by in situ hybridisation)   (Oda et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\α-Cat for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) α-Cat-RA FBtr0070038  NM_079495   2977   917
Additional Transcript Data & Comments
Reported size (kB)	3.4 (northern blot) (Oda et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein alpha-Cat-PA   FBpp0070037   102.4   917   6.35     NP_524219   AAF45466
Additional Polypeptide Data & Comments
Reported size (kDa)	935 (aa); 110 (kD observed) (Oda et al., 1993)
Comments	A 76 amino acid region of arm protein is necessary and sufficient for binding α-Cat protein; point mutations in this region abolish α-Cat binding in vitro. The N-terminal 258 amino acids of α-Cat interact with arm protein. (Pai et al., 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Vinculin, conserved site (IPR000633) Alpha-catenin (IPR001033) Vinculin/alpha-catenin (IPR006077)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201518   AA246355   AA264062   AA264554   AA438723   AA439515   AA439888   AA440869   AA538568   AA538672   AA540168   AA540868   AA541099   AA695420   AA948884   AA950570   AA979044   AE014296 AAF45466   AI295282   AI403441   AI533988   AW943025   AY051780 AAK93204   BG639290   BI161756   BI161757   BI162991   BI164626   BI167626   BI168465   BI169821   BI169861   BI170094   BI172672   BI173221   BI213403   BI215077   BI216878   BI216985   BI227741   BI228799   BI233290   BI238197   BI238588   BI241786   BI242014   BI243705   BI357340   BI357874   BI358234   BI358295   BI363829   BI365392   BI366279   BI366929   BI368810   BI375905   BI482530   BI482565   BI483619   BI485169   BI486160   BI487112   BI578630   BI579063   BI579659   BI580912   BI638457   BI641635   BP559492   BP559493   CO155408   CO177335   CO266650   CO267094   CO267412   CO271503   CO271739   CO271755   CO281265   CO281875   CO295483   CO302564   CO307802   CO311735   CO315589   CO315943   CO319617   CO338266   D13964 BAA03067   DN154029   EC066975   EC071595   EC073079   EC073395   EC077913   EC082066   EC084740   EC084746   EC087111   EC088710   EC200339   EC204675   EC212793   EC214947   EC215801   EC226744   EC232141   EC233462   EC238874   EC243454   EC245053   EC248191   EC266206   EV575048   EV576373   EV578962   EV586606   EV593128
UniProtKB/Swiss-Prot	P35220
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage & adult stage   organism   (Oda et al., 1993) third instar larval stage     (Oda et al., 1993)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 17   organism   (Oda et al., 1993) ectoderm   (Oda et al., 1993) embryonic stage 11   ventral midline   (Oda et al., 1993) embryonic stage 16   presumptive embryonic/larval peripheral nervous system   (Oda et al., 1993) embryonic/larval midgut   (Oda et al., 1993) presumptive embryonic/larval central nervous system   (Oda et al., 1993) epidermis   (Oda et al., 1993) embryonic/larval foregut   (Oda et al., 1993) embryonic/larval hindgut   (Oda et al., 1993) third instar larval stage   morphogenetic furrow | posterior to   (Oda et al., 1993) morphogenetic furrow | anterior to & ubiquitous   (Oda et al., 1993) embryonic/larval salivary gland duct   (Oda et al., 1993) ommatidial precursor cluster   (Oda et al., 1993) eye disc   (Oda et al., 1993) ventral thoracic disc | restricted   (Oda et al., 1993) pupal stage P7   lamina   (Iwai et al., 2002) Comment:reference states 40% pupal development medulla   (Iwai et al., 2002) Comment:reference states 40% pupal development
Additional Descriptive Data
	intercellular junction (Oda et al., 1993)
Marker for
Subcellular Localization
CV Term	adherens junction (Pai et al., 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010215    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010215 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010215 expression level Developmental Stage   Expression Level embryo 00-02hr    3852 embryo 02-04hr    6535 embryo 04-06hr    9057 embryo 06-08hr    6251 embryo 08-10hr    6725 embryo 10-12hr    4654 embryo 12-14hr    8697 embryo 14-16hr    2252 embryo 16-18hr    3329 embryo 18-20hr    1857 embryo 20-22hr    3328 embryo 22-24hr    4319 larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6    2284 larva L3 puffstage 7-9    4489 white prepupae new    4530 white prepupae 12hr    4420 white prepupae 24hr    4638 pupae 2d postWPP    3758 pupae 3d postWPP    2609 pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day    3073 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3852) embryo 02-04hr  (6535) embryo 04-06hr  (9057) embryo 06-08hr  (6251) embryo 08-10hr  (6725) embryo 10-12hr  (4654) embryo 12-14hr  (8697) embryo 14-16hr  (2252) embryo 16-18hr  (3329) embryo 18-20hr  (1857) embryo 20-22hr  (3328) embryo 22-24hr  (4319) larva L1  (1115) larva L2  (1343) larva L3 12hr old  (1023) larva L3 puffstage 1-2  (1351) larva L3 puffstage 3-6  (2284) larva L3 puffstage 7-9  (4489) white prepupae new  (4530) white prepupae 12hr  (4420) white prepupae 24hr  (4638) pupae 2d postWPP  (3758) pupae 3d postWPP  (2609) pupae 4d postWPP  (902) adult male 01day  (1390) adult male 05day  (1005) adult male 30day  (738) adult female 01day  (982) adult female 05day  (3073) adult female 30day  (2230) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3852) embryo 02-04hr  (6535) embryo 04-06hr  (9057) embryo 06-08hr  (6251) embryo 08-10hr  (6725) embryo 10-12hr  (4654) embryo 12-14hr  (8697) embryo 14-16hr  (2252) embryo 16-18hr  (3329) embryo 18-20hr  (1857) embryo 20-22hr  (3328) embryo 22-24hr  (4319) larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6  (2284) larva L3 puffstage 7-9  (4489) white prepupae new  (4530) white prepupae 12hr  (4420) white prepupae 24hr  (4638) pupae 2d postWPP  (3758) pupae 3d postWPP  (2609) pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day  (3073) adult female 30day  (2230) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3852 embryo 02-04hr    6535 embryo 04-06hr    9057 embryo 06-08hr    6251 embryo 08-10hr    6725 embryo 10-12hr    4654 embryo 12-14hr    8697 embryo 14-16hr    2252 embryo 16-18hr    3329 embryo 18-20hr    1857 embryo 20-22hr    3328 embryo 22-24hr    4319 larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6    2284 larva L3 puffstage 7-9    4489 white prepupae new    4530 white prepupae 12hr    4420 white prepupae 24hr    4638 pupae 2d postWPP    3758 pupae 3d postWPP    2609 pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day    3073 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3852 embryo 02-04hr    6535 embryo 04-06hr    9057 embryo 06-08hr    6251 embryo 08-10hr    6725 embryo 10-12hr    4654 embryo 12-14hr    8697 embryo 14-16hr    2252 embryo 16-18hr    3329 embryo 18-20hr    1857 embryo 20-22hr    3328 embryo 22-24hr    4319 larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6    2284 larva L3 puffstage 7-9    4489 white prepupae new    4530 white prepupae 12hr    4420 white prepupae 24hr    4638 pupae 2d postWPP    3758 pupae 3d postWPP    2609 pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day    3073 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010215 expression level Developmental Stage   Expression Level embryo 00-02hr    3852 embryo 02-04hr    6535 embryo 04-06hr    9057 embryo 06-08hr    6251 embryo 08-10hr    6725 embryo 10-12hr    4654 embryo 12-14hr    8697 embryo 14-16hr    2252 embryo 16-18hr    3329 embryo 18-20hr    1857 embryo 20-22hr    3328 embryo 22-24hr    4319 larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6    2284 larva L3 puffstage 7-9    4489 white prepupae new    4530 white prepupae 12hr    4420 white prepupae 24hr    4638 pupae 2d postWPP    3758 pupae 3d postWPP    2609 pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day    3073 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3852) embryo 02-04hr  (6535) embryo 04-06hr  (9057) embryo 06-08hr  (6251) embryo 08-10hr  (6725) embryo 10-12hr  (4654) embryo 12-14hr  (8697) embryo 14-16hr  (2252) embryo 16-18hr  (3329) embryo 18-20hr  (1857) embryo 20-22hr  (3328) embryo 22-24hr  (4319) larva L1  (1115) larva L2  (1343) larva L3 12hr old  (1023) larva L3 puffstage 1-2  (1351) larva L3 puffstage 3-6  (2284) larva L3 puffstage 7-9  (4489) white prepupae new  (4530) white prepupae 12hr  (4420) white prepupae 24hr  (4638) pupae 2d postWPP  (3758) pupae 3d postWPP  (2609) pupae 4d postWPP  (902) adult male 01day  (1390) adult male 05day  (1005) adult male 30day  (738) adult female 01day  (982) adult female 05day  (3073) adult female 30day  (2230) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3852) embryo 02-04hr  (6535) embryo 04-06hr  (9057) embryo 06-08hr  (6251) embryo 08-10hr  (6725) embryo 10-12hr  (4654) embryo 12-14hr  (8697) embryo 14-16hr  2252 embryo 16-18hr  (3329) embryo 18-20hr  1857 embryo 20-22hr  (3328) embryo 22-24hr  (4319) larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6  2284 larva L3 puffstage 7-9  (4489) white prepupae new  (4530) white prepupae 12hr  (4420) white prepupae 24hr  (4638) pupae 2d postWPP  (3758) pupae 3d postWPP  (2609) pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day  (3073) adult female 30day  2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3852 embryo 02-04hr    6535 embryo 04-06hr    9057 embryo 06-08hr    6251 embryo 08-10hr    6725 embryo 10-12hr    4654 embryo 12-14hr    8697 embryo 14-16hr    2252 embryo 16-18hr    3329 embryo 18-20hr    1857 embryo 20-22hr    3328 embryo 22-24hr    4319 larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6    2284 larva L3 puffstage 7-9    4489 white prepupae new    4530 white prepupae 12hr    4420 white prepupae 24hr    4638 pupae 2d postWPP    3758 pupae 3d postWPP    2609 pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day    3073 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3852 embryo 02-04hr    6535 embryo 04-06hr    9057 embryo 06-08hr    6251 embryo 08-10hr    6725 embryo 10-12hr    4654 embryo 12-14hr    8697 embryo 14-16hr    2252 embryo 16-18hr    3329 embryo 18-20hr    1857 embryo 20-22hr    3328 embryo 22-24hr    4319 larva L1    1115 larva L2    1343 larva L3 12hr old    1023 larva L3 puffstage 1-2    1351 larva L3 puffstage 3-6    2284 larva L3 puffstage 7-9    4489 white prepupae new    4530 white prepupae 12hr    4420 white prepupae 24hr    4638 pupae 2d postWPP    3758 pupae 3d postWPP    2609 pupae 4d postWPP    902 adult male 01day    1390 adult male 05day    1005 adult male 30day    738 adult female 01day    982 adult female 05day    3073 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010215    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010215 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010215 expression level Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1006.625) Larval Midgut    395.5 Larval Hindgut  (588.5) Larval Malpighian Tubules  (695.2) Larval Fat Body    408.3 Larval Salivary Gland  (544.2) Larval Trachea  (629.925) Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain  (849.6) Adult Thoracic-Abdominal Ganglion  (781.9) Adult Crop  531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules  (547.6) Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary  (862.5) Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010215 expression level Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1006.625) Larval Midgut    395.5 Larval Hindgut  588.5 Larval Malpighian Tubules  695.2 Larval Fat Body    408.3 Larval Salivary Gland  544.2 Larval Trachea  629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain  (849.6) Adult Thoracic-Abdominal Ganglion  781.9 Adult Crop  531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules  547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary  (862.5) Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    435.9   NA  Eye    442.625   NA  Brain    849.6   1006.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    781.9   NA  Crop    531.6   395.5  Midgut    330.7   588.5  Hindgut    403.9   695.2  Malpighian Tubules    547.6   408.3  Fat Body    205.5   544.2  Salivary Gland    479.6   NA  Heart    245.475   629.925  Trachea    NA   NA  VirginFemale Spermatheca    339.5   NA  InseminatedFemale Spermatheca    466.4   NA  Ovary    862.5   NA  Testis    222.2   NA  Male Accessory Gland    497.4   461.475  Carcass    212.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010215 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17947-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially, with Scer\GAL4Act5C.PI α-CatScer\UAS.P\T.cMa lethal | pupal stage, with Scer\GAL4pnr-MD237 α-CatGD8808 Other Phenotypes Allele neuroanatomy defective α-CatScer\UAS.T:Avic\GFP-sg Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of α-Cat Class Mutagen Stocks Known lesion α-CatMI02577 1 -- α-CatCPTI002342 piggyBac transposase 0 Yes α-CatCPTI002516 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of α-Cat Class Mutagen Stocks Known lesion α-CatGD8808 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes α-CatHMS00317 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-CatKK107916 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-CatScer\UAS.T:Avic\GFP-sg in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes α-Cata.cMa in vitro construct - RNAi 0 Yes α-CatcMa in vitro construct - RNAi 0 Yes α-CatdsRNA.cYa in vitro construct - RNAi 0 Yes α-CatScer\UAS.P\T.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UASp-α-Cat.M} NA P{UAS-α-Cat.T:GFP.sg} NA characterization construct P{UAS-α-Cat::shg.N} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}α-CatMI02577 NA PBac{544.SVS-1}α-CatCPTI002342 NA PBac{681.P.FSVS-1}α-CatCPTI002516 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cell-cell adherens junction inferred from direct assay (Wang et al., 2006) plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) cadherin binding inferred from electronic annotation with InterPro:IPR001033 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) cytoskeletal protein binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural molecule activity inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR001033, InterPro:IPR006077 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR001033, InterPro:IPR006077 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) cytoskeletal anchoring at plasma membrane inferred from sequence or structural similarity (Hynes and Zhao, 2000) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) oocyte localization involved in germarium-derived egg chamber formation traceable author statement (Deng and Lin, 2001)
Cellular Component
CV term Evidence References
actin cytoskeleton inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR001033, InterPro:IPR006077 (FlyBase Curators et al., 2004-) adherens junction non-traceable author statement (Humbert et al., 2003, Harden, 2002) catenin complex inferred from sequence or structural similarity (Hynes and Zhao, 2000) cell-substrate junction non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) spot adherens junction non-traceable author statement (Wedlich, 2002) zonula adherens non-traceable author statement (Oda, 1993, Muller, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions α-Cat allele Gene References α-CatScer\UAS.P\T.cMa Rho1 (Magie et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65744 DroID - A comprehensive database of gene and protein interactions. • FBgn0010215 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40517
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20570 Dere\GG16297 Dgri\α-Cat Dmoj\GI23967 Dper\GL21877 Dpse\GA22221 Dsec\GM22485 Dsim\GD12044 Dvir\GJ11153 Dwil\GK11940 Dyak\GE19475
Curated drosophilid orthologs	Dana\α-Cat (Sztal et al., 2007) Dgri\α-Cat   Dmoj\α-Cat (Sztal et al., 2007) Dper\α-Cat (Sztal et al., 2007) Dpse\alpha-Cat (Sztal et al., 2007) Dwil\α-Cat (Sztal et al., 2007)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003754-PB Aedes aegypti (mosquito) AGAP003424-PA Anopheles gambiae (mosquito) XP_625229.1 Apis mellifera (honey bee) XP_001944375.1 Acyrthosiphon pisum (pea aphid) 115174 Branchiostoma floridae (lancelet) 126221 Branchiostoma floridae (lancelet) XP_001892620.1 Brugia malayi (roundworm nematode) BGIBMGA011888-PA Bombyx mori (silk worm) ENSBTAP00000018861 Bos taurus (bovine) CN18955 Caenorhabditis brenneri (small nematode) CBP12379 Caenorhabditis briggsae (nematode) CE40995 Caenorhabditis elegans (worm) ENSCAFP00000001898 Canis familiaris (dog) ENSCINP00000018199 Ciona intestinalis (sea squirt) JA06573 Caenorhabditis japonica (nematode) CPIJ005773 Culex pipens (mosquito) ENSCPOP00000012052 Cavia porcellus (guinea pig) RP10498 Caenorhabditis remanei (nematode) 179193 Capitella spl (polychaete worm) 309973 Daphnia pulex (daphnia) ENSDARP00000092080 Danio rerio (zebra fish) ENSECAP00000021721 Equus caballus (horse) ENSGACP00000023764 Gymnopilus aculeatus (mushroom) ENSGALP00000025681 Gallus gallus (chicken) 101461 Hypsipyla robusta (cedar shoot borer) ENSP00000384638 Homo sapiens (human) ISCW022677-PA Ixodes scapularis (deer tick) 178587 Lottia gigantea (owl limpet) ENSMODP00000019286 Monodelphis domestica (gray opossum) ENSMMUP00000036414 Macaca mulatta (rhesus monkey) ENSMUSP00000078277 Mus musculus (house mouse) 82641 Nematostella vectensis (starlet anemone) ENSOANP00000005566 Ornithorynchus anatinus (platypus) ENSORLP00000009022 Oryzias latipes (japanese killifish) PHUM004282-PA Pediculus humanus (human body louse) ENSPPYP00000013655 Pongo pygmaeus (orangutan) ENSPTRP00000039080 Pan troglodytes (chimpanzee) ENSRNOP00000008041 Rattus norvegicus (norway rat) XP_001195471.1 Strongylocentrotus purpuratus (purple sea urchin) 28149 Trichoplax adhaerens (metazoa) XP_970159.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011862 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000006660 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000018423 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50125 LH18193 ISCW022677 FBgn0236817 FBgn0213951 FBgn0198414 FBgn0183782 FBgn0183783 FBgn0177355 JGI_V11_309973 FBgn0243628 FBgn0159470 FBgn0146691 FBgn0023361 FBgn0108530 FBgn0097576 CPIJ005773 BGIBMGA011890 BGIBMGA011888 ACYPI002275 GB12545 AGAP003424 AAEL003754 PB26128 PHUM450820 GLEAN_04609
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	35870 y1 w*; Mi{MIC}α-CatMI02577 33430 y1 sc* v1; P{TRiP.HMS00317}attP2
Kyoto	109001 w*; P{UAS-α-Cat.T:GFP.sg}3 / CyO
VDRC	v107298 P{KK107916}VIE-260B v19182 w1118; P{GD8808}v19182 v20123 w1118; P{GD8808}v20123 v40882 w1118; P{GD8808}v40882/CyO
Genomic Clones ( 2 )
	BACR22B15 BACR34K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 112 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD30423
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22876 GM02796 LD04577 LD05188 LD07464 LD07667 LD14106 LD14569 LD15926 LD18130 LD18254 LD19561 LD20701 LD20893 LD27559 LD33292 LP02592 LP08869 RE02278 RE04336 RE08048 RE09202 RE11106 RE11157 RE11447 RE15315 RE15988 RE18795 RE21283 RE24160 RE24492 RE24962 RE26443 RE29593 RE34591 RE35081 RE38955 RE39228 RE41422 RE43792 RE44478 RE44938 RE45029 RE48781 RE50681 RE51783 RE52570 RE54850 RE63810 RE65230 RE65270 RE66536 RE68455 RE69542 RE70623 RE72522 RE73036 RE73726 RE75160 SD06388 SD20749 SD25088
Other clones	34368 36712 37936 39632 39746 42094 59501 76856 79723 102383 125652 149486 158886 160459 173130 174604 178578 571213 CK01.103D.A8 CK01.168A.G9 CK01.168D.H4 CK01.170B.G6 Dmel_dig_000759_0697_3656 Dmel_dig_000973_0714_0337 Dmel_dig_014531_0609_0793 Dmel_neb_010551_0114_0586 Dmel_neb_011186_0682_1770 EK053206 EK103662 EK104459 EK104520 EK147135 EK148719 EK150052 EK155245 EK156323 EK159003 EK184434 EK210046 EK226034 EK255710 EK261937 EK263160 EK279356 EN06009 EN16342 FGM321C05 LD13062 RE01171
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010215 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40517
Antibody Information
	monoclonal (Oda et al., 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Multiple regions of homology in the Vinc and α-Cat sequences suggest the proteins may have overlapping functions. (Alatortsev, 1997) The binding sites for shg and α-Cat are mapped on arm protein, these bind independently of each other to arm and binding of each is required for the function of adherens junctions. (Orsulic and Peifer, 1996) Yeast two-hybrid system and in vivo assays have identified a 76 amino acid region of arm that is necessary and sufficient for binding α-Cat and also that the N-terminal 258 amino acids of α-Cat interact with arm. (Pai et al., 1996) Isolated from a genomic library, using a mouse αE-catenin cDNA as a probe, under low stringency conditions. (Oda et al., 1993) α-catenin is a component of a membrane-associated complex that includes the arm and aagp gene products. (Oda et al., 1993) α-Cat has been cloned and sequenced, and its expression pattern has been analysed. (Oda et al., 1993) The α-Cat gene product is part of a membrane-associated complex that includes the arm and aagp gene products. (Peifer, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079495 RefSeq (Proteins) • NP_524219 DDBJ / EMBL / GenBank • AA950570 AAF45466 AAK93204 AW943025 AY051780 BAA03067 D13964 Entrez Gene - A searchable database of RefSeq genes. • 40517 UniProtKB/Swiss-Prot • P35220
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Vinculin, conserved site (IPR000633) Alpha-catenin (IPR001033) Vinculin/alpha-catenin (IPR006077)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65744 DroID - A comprehensive database of gene and protein interactions. • FBgn0010215 DRSC - Results from RNAi screens. • FBgn0010215 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010215 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17947-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010215 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40517 InParanoid A subset of ortholog calls from InParanoid. • AAEL003754-PB Aedes aegypti (mosquito) AGAP003424-PA Anopheles gambiae (mosquito) XP_625229.1 Apis mellifera (honey bee) XP_001944375.1 Acyrthosiphon pisum (pea aphid) 115174 Branchiostoma floridae (lancelet) 126221 Branchiostoma floridae (lancelet) XP_001892620.1 Brugia malayi (roundworm nematode) BGIBMGA011888-PA Bombyx mori (silk worm) ENSBTAP00000018861 Bos taurus (bovine) CN18955 Caenorhabditis brenneri (small nematode) CBP12379 Caenorhabditis briggsae (nematode) CE40995 Caenorhabditis elegans (worm) ENSCAFP00000001898 Canis familiaris (dog) ENSCINP00000018199 Ciona intestinalis (sea squirt) JA06573 Caenorhabditis japonica (nematode) CPIJ005773 Culex pipens (mosquito) ENSCPOP00000012052 Cavia porcellus (guinea pig) RP10498 Caenorhabditis remanei (nematode) 179193 Capitella spl (polychaete worm) 309973 Daphnia pulex (daphnia) ENSDARP00000092080 Danio rerio (zebra fish) ENSECAP00000021721 Equus caballus (horse) ENSGACP00000023764 Gymnopilus aculeatus (mushroom) ENSGALP00000025681 Gallus gallus (chicken) 101461 Hypsipyla robusta (cedar shoot borer) ENSP00000384638 Homo sapiens (human) ISCW022677-PA Ixodes scapularis (deer tick) 178587 Lottia gigantea (owl limpet) ENSMODP00000019286 Monodelphis domestica (gray opossum) ENSMMUP00000036414 Macaca mulatta (rhesus monkey) ENSMUSP00000078277 Mus musculus (house mouse) 82641 Nematostella vectensis (starlet anemone) ENSOANP00000005566 Ornithorynchus anatinus (platypus) ENSORLP00000009022 Oryzias latipes (japanese killifish) PHUM004282-PA Pediculus humanus (human body louse) ENSPPYP00000013655 Pongo pygmaeus (orangutan) ENSPTRP00000039080 Pan troglodytes (chimpanzee) ENSRNOP00000008041 Rattus norvegicus (norway rat) XP_001195471.1 Strongylocentrotus purpuratus (purple sea urchin) 28149 Trichoplax adhaerens (metazoa) XP_970159.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011862 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000006660 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000018423 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40517 modMine - Data generated by the modENCODE project. • FBgn0010215 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50125 LH18193 ISCW022677 FBgn0236817 FBgn0213951 FBgn0198414 FBgn0183782 FBgn0183783 FBgn0177355 JGI_V11_309973 FBgn0243628 FBgn0159470 FBgn0146691 FBgn0023361 FBgn0108530 FBgn0097576 CPIJ005773 BGIBMGA011890 BGIBMGA011888 ACYPI002275 GB12545 AGAP003424 AAEL003754 PB26128 PHUM450820 GLEAN_04609
Synonyms & Secondary IDs ( 33 )
Reported As
Symbol Synonym	a-cat (Coulier et al., 2000) a-Cat (Zhou et al., 2007) alpha-Cat (Greil et al., 2003, Giot et al., 2003, Bakal et al., 2007) alpha-cat (Langton et al., 2009) CG17947 (Whitfield, 2001.2.19, Whitfield, 2000.12.19, Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Khanna et al., 2010, Ni et al., 2010.12.1) CT39986 (Hynes and Zhao, 2000) Dmcatp (Alatortsev, 1997) DαC (Knox and Brown, 2002) Dα-cat (Ribeiro et al., 2004, Tepass et al., 2001, Langevin et al., 2005) Dαcat (Beronja et al., 2005) Dα-Cat (Kessler and Müller, 2009) αcat (Myster et al., 2003, Van Etten, 1999, Harris and Peifer, 2004) α-cat (McCartney et al., 2001, Harris and Peifer, 2004, Andreyeva et al., 2007, Gorfinkiel and Arias, 2007, Homem and Peifer, 2008, Warner and Longmore, 2009, Baer et al., 2010) α-CAT (Kramer, 2000) α-Cat (Jung et al., 2006, Vidal et al., 2006, Dimitri et al., 2003, Cavey et al., 2008, Cabernard and Affolter, 2005) αCat (Simoes et al., 2006, Caussinus et al., 2008, Sawyer et al., 2009, Kaplan et al., 2009) αCAT (Shindo et al., 2008) α-catenin (Kaplan and Tolwinski, 2010) α-ctn (Magie et al., 2002)
Name Synonym	a-catenin (Zhou et al., 2007) alpha-Catenin (Dimitri et al., 2005, Wang et al., 2000) alpha-catenin (Bienz and Hamada, 2004, Oda, 1993, Gates et al., 2007, Georgiou et al., 2008, Kaido et al., 2009) alpha Catenin (Khanna et al., 2010) Dα-cadherin (Oda et al., 1996) Dα-catenin (Denholm and Skaer, 2003, Uv et al., 2003, Humbert et al., 2003, Muller, 2003, Wedlich, 2002, Yanagawa et al., 2002, Yagi and Takeichi, 2000, Yanagawa et al., 2000, Muller, 2000, Tepass, 1999, Lee et al., 1999, Oda and Tsukita, 1999, Takahashi et al., 1998, Oda et al., 1998, White et al., 1998, Martinek and Gaul, 1997, Yanagawa et al., 1997, Tepass, 1997, Oda et al., 1997, Goto and Hayashi, 1997, Tanaka-Matakatsu et al., 1996, Tepass, 1996, Fuse et al., 1996, Oda et al., 1993, Beronja et al., 2005, Iwai et al., 2002, Wang et al., 2006, Shindo et al., 2008, Paul and Beitel, 2005) DαCatenin (Mueller and Bossinger, 2003) D-α-catenin (Yanagawa et al., 1998) Dα-Catenin (Schumacher et al., 2004, Kessler and Müller, 2009) α-catenin (Lee et al., 2010, Chanut-Delalande et al., 2006, Torres et al., 2003, Polesello and Payre, 2004, Harris et al., 2004, Lopez-Schier, 2003, Perez-Moreno et al., 2003, Gonczy, 2002, Rorth, 2002, Fox et al., 2003, Akong et al., 2002, Renfranz and Beckerle, 2002, Schock and Perrimon, 2002, Deng and Lin, 2001, Cox et al., 1999, Cox et al., 1996, Kirkpatrick and Peifer, 1995, Pai et al., 1996, Orsulic and Peifer, 1996, Weis and Nelson, 2006, Pacquelet and Rorth, 2005, Montell, 2006, Desai et al., 2008, Sarpal et al., 2008, Zimmerman et al., 2008, McCaffrey et al., 2006, Cliffe et al., 2004, Wodarz et al., 2006, Gorfinkiel and Arias, 2007, Homem and Peifer, 2008, Larson et al., 2008, Qin et al., 2007, Johnson et al., 2008, Goldbach et al., 2010, Martin et al., 2010, Kaplan et al., 2009) α Catenin   αCatenin (Abrams et al., 2006, Caussinus et al., 2008) α catenin (Hoopfer et al., 2008) α-Catenin (Somers and Chia, 2005, Margolis and Borg, 2005, Cavey et al., 2008, Seppa et al., 2008, Georgiou et al., 2008, Cordero et al., 2007, Warner and Longmore, 2009, Sekyrova et al., 2010, Simone and DiNardo, 2010) αcatenin (Haghayeghi et al., 2010)
Secondary FlyBase IDs
	FBan0017947
References ( 190 )
Generate a list of	All references relating to this gene ( 190 )
List References by type	Research paper  ( 101 ) Supplementary material  ( 9 ) Review  ( 47 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 17 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 10 )
	Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Baer et al., 2010, Mech. Dev. 127(1-2): 28--35 The role of apoptosis in shaping the tracheal system in the Drosophila embryo. [FBrf0209865] Gettings et al., 2010, PLoS Biol. 8(6): e1000390 JNK Signalling Controls Remodelling of the Segment Boundary through Cell Reprogramming during Drosophila Morphogenesis. [FBrf0211014] Goldbach et al., 2010, Mol. Biol. Cell 21(9): 1482--1493 Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. [FBrf0210683] Haghayeghi et al., 2010, Mech. Dev. 127(5-6): 301--307 Pellino enhances innate immunity in Drosophila. [FBrf0210800] Kaplan and Tolwinski, 2010, J. Cell Sci. 123(18): 3157--3165 Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. [FBrf0211705] Lee et al., 2010, J. Cell Sci. 123(2): 277--285 The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila. [FBrf0209565] Martin et al., 2010, J. Cell Biol. 188(5): 735--749 Integration of contractile forces during tissue invagination. [FBrf0210158] Sekyrova et al., 2010, Development 137(1): 141--150 Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550] Simone and DiNardo, 2010, Development 137(8): 1385--1394 Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. [FBrf0210407] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...