• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\α-Cat

General Information
Symbol	Dmel\α-Cat	Species	D. melanogaster
Name	α Catenin	Annotation symbol	CG17947
Feature type	protein_coding_gene	FlyBase ID	FBgn0010215
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	αcat, Dα-cat, alpha-Cat, a-cat, α-catenin
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	80F1-80F2	Sequence location	3L:23,311,746..23,331,200 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α Catenin is referred to in FlyBase by the symbol Dmel\α-Cat (CG17947, FBgn0010215). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. Based on sequence similarity, it is predicted to be involved in the biological process: cytoskeletal anchoring at plasma membrane. 16 alleles are reported. The phenotypes of these alleles are annotated with: male genitalia; cone cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Alpha-catenin; Vinculin, conserved site; Vinculin/alpha-catenin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632724_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alpha-Cat. Gene sequence location is 3L:23311746..23331200.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 80F1-80F2   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 80B-80B   (determined by in situ hybridisation)   (Oda et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\α-Cat for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) α-Cat-RA FBtr0070038  NM_079495   3000   917 α-Cat-RB FBtr0339894     3487   372
Additional Transcript Data & Comments
Reported size (kB)	3.4 (northern blot) (Oda et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein α-Cat-PA   FBpp0070037   102.4   917   6.35     NP_524219   AAF45466 α-Cat-PB   FBpp0308926   41.4   372   6.54
Additional Polypeptide Data & Comments
Reported size (kDa)	935 (aa); 110 (kD observed) (Oda et al., 1993)
Comments	A 76 amino acid region of arm protein is necessary and sufficient for binding α-Cat protein; point mutations in this region abolish α-Cat binding in vitro. The N-terminal 258 amino acids of α-Cat interact with arm protein. (Pai et al., 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Vinculin, conserved site (IPR000633) Alpha-catenin (IPR001033) Vinculin/alpha-catenin (IPR006077)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201518   AA246355   AA264062   AA264554   AA438723   AA439515   AA439888   AA440869   AA538568   AA538672   AA540168   AA540868   AA541099   AA695420   AA948884   AA950570   AA979044   AE014296 AAF45466   AI295282   AI403441   AI533988   AW943025   AY051780 AAK93204   BG639290   BI161756   BI161757   BI162991   BI164626   BI167626   BI168465   BI169821   BI169861   BI170094   BI172672   BI173221   BI213403   BI215077   BI216878   BI216985   BI227741   BI228799   BI233290   BI238197   BI238588   BI241786   BI242014   BI243705   BI357340   BI357874   BI358234   BI358295   BI363829   BI365392   BI366279   BI366929   BI368810   BI375905   BI482530   BI482565   BI483619   BI485169   BI486160   BI487112   BI578630   BI579063   BI579659   BI580912   BI638457   BI641635   BP559492   BP559493   BT132775   BT133504   CO155408   CO177335   CO266650   CO267094   CO267412   CO271503   CO271739   CO271755   CO281265   CO281875   CO295483   CO302564   CO307802   CO311735   CO315589   CO315943   CO319617   CO338266   D13964 BAA03067   DN154029   EC066975   EC071595   EC073079   EC073395   EC077913   EC082066   EC084740   EC084746   EC087111   EC088710   EC200339   EC204675   EC212793   EC214947   EC215801   EC226744   EC232141   EC233462   EC238874   EC243454   EC245053   EC248191   EC266206   EV575048   EV576373   EV578962   EV586606   EV593128
UniProtKB/Swiss-Prot	P35220
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage & adult stage   organism   (Oda et al., 1993) third instar larval stage     (Oda et al., 1993)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 17   organism   (Oda et al., 1993) ectoderm   (Oda et al., 1993) embryonic stage 11   ventral midline   (Oda et al., 1993) embryonic stage 16   presumptive embryonic/larval peripheral nervous system   (Oda et al., 1993) embryonic/larval midgut   (Oda et al., 1993) presumptive embryonic/larval central nervous system   (Oda et al., 1993) epidermis   (Oda et al., 1993) embryonic/larval foregut   (Oda et al., 1993) embryonic/larval hindgut   (Oda et al., 1993) third instar larval stage   morphogenetic furrow | posterior to   (Oda et al., 1993) morphogenetic furrow | anterior to & ubiquitous   (Oda et al., 1993) embryonic/larval salivary gland duct   (Oda et al., 1993) ommatidial precursor cluster   (Oda et al., 1993) eye disc   (Oda et al., 1993) ventral thoracic disc | restricted   (Oda et al., 1993) pupal stage P7   lamina   (Iwai et al., 2002) Comment:reference states 40% pupal development medulla   (Iwai et al., 2002) Comment:reference states 40% pupal development
Additional Descriptive Data
	intercellular junction (Oda et al., 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell-cell adherens junction inferred from direct assay (Wang et al., 2006) plasma membrane inferred from direct assay (Khanna et al., 2010, Dottermusch-Heidel et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1006.625) Larval Midgut    395.5 Larval Hindgut  (588.5) Larval Malpighian Tubules  (695.2) Larval Fat Body    408.3 Larval Salivary Gland  (544.2) Larval Trachea  (629.925) Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain  (849.6) Adult Thoracic-Abdominal Ganglion  (781.9) Adult Crop  531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules  (547.6) Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary  (862.5) Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1006.625) Larval Midgut    395.5 Larval Hindgut  588.5 Larval Malpighian Tubules  695.2 Larval Fat Body    408.3 Larval Salivary Gland  544.2 Larval Trachea  629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain  (849.6) Adult Thoracic-Abdominal Ganglion  781.9 Adult Crop  531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules  547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary  (862.5) Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1006.625 Larval Midgut    395.5 Larval Hindgut    588.5 Larval Malpighian Tubules    695.2 Larval Fat Body    408.3 Larval Salivary Gland    544.2 Larval Trachea    629.925 Larval Carcass    461.475 Adult Head    435.9 Adult Eye    442.625 Adult Brain    849.6 Adult Thoracic-Abdominal Ganglion    781.9 Adult Crop    531.6 Adult Midgut    330.7 Adult Hindgut    403.9 Adult Malpighian Tubules    547.6 Adult Fat Body    205.5 Adult Salivary Gland    479.6 Adult Heart    245.475 Adult VirginFemale Spermatheca    339.5 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    862.5 Adult Testis    222.2 Adult Male Accessory Gland    497.4 Adult Carcass    212.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    435.9   NA  Eye    442.625   NA  Brain    849.6   1006.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    781.9   NA  Crop    531.6   395.5  Midgut    330.7   588.5  Hindgut    403.9   695.2  Malpighian Tubules    547.6   408.3  Fat Body    205.5   544.2  Salivary Gland    479.6   NA  Heart    245.475   629.925  Trachea    NA   NA  VirginFemale Spermatheca    339.5   NA  InseminatedFemale Spermatheca    466.4   NA  Ovary    862.5   NA  Testis    222.2   NA  Male Accessory Gland    497.4   461.475  Carcass    212.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    48 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male    27 head, mated 20-day male    28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering    27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female    60 ovary, mated 4-day female    41 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (30) central nervous system, larvae L3  (48) central nervous system, pupae P8  (62) head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male  (27) head, mated 20-day male  (28) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  (30) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering  (27) carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (41) testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    48 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male    27 head, mated 20-day male    28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering    27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female    60 ovary, mated 4-day female    41 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    48 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male    27 head, mated 20-day male    28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering    27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female    60 ovary, mated 4-day female    41 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    48 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male    27 head, mated 20-day male    28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering    27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female    60 ovary, mated 4-day female    41 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  30 central nervous system, larvae L3  (48) central nervous system, pupae P8  (62) head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male  27 head, mated 20-day male  28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering  27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (41) testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    48 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male    27 head, mated 20-day male    28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering    27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female    60 ovary, mated 4-day female    41 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    48 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    15 head, virgin 20-day female    11 head, mated 1-day female    12 head, mated 4-day female    16 head, mated 20-day female    10 head, mated 1-day male    21 head, mated 4-day male    27 head, mated 20-day male    28 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    21 carcass, larvae L3 wandering    27 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    7 ovary, virgin 4-day female    60 ovary, mated 4-day female    41 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    73 embryo 04-06hr    102 embryo 06-08hr    70 embryo 08-10hr    76 embryo 10-12hr    52 embryo 12-14hr    98 embryo 14-16hr    25 embryo 16-18hr    38 embryo 18-20hr    21 embryo 20-22hr    37 embryo 22-24hr    49 larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    51 white prepupae new    51 white prepupae 12hr    50 white prepupae 24hr    52 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day    35 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr  (73) embryo 04-06hr  (102) embryo 06-08hr  (70) embryo 08-10hr  (76) embryo 10-12hr  (52) embryo 12-14hr  (98) embryo 14-16hr    25 embryo 16-18hr  (38) embryo 18-20hr    21 embryo 20-22hr  (37) embryo 22-24hr  (49) larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (51) white prepupae new  (51) white prepupae 12hr  (50) white prepupae 24hr  (52) pupae 2d postWPP  (42) pupae 3d postWPP  (29) pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day  (35) adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    73 embryo 04-06hr  102 embryo 06-08hr    70 embryo 08-10hr    76 embryo 10-12hr    52 embryo 12-14hr    98 embryo 14-16hr    25 embryo 16-18hr    38 embryo 18-20hr    21 embryo 20-22hr    37 embryo 22-24hr    49 larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    51 white prepupae new    51 white prepupae 12hr    50 white prepupae 24hr    52 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day    35 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    73 embryo 04-06hr    102 embryo 06-08hr    70 embryo 08-10hr    76 embryo 10-12hr    52 embryo 12-14hr    98 embryo 14-16hr    25 embryo 16-18hr    38 embryo 18-20hr    21 embryo 20-22hr    37 embryo 22-24hr    49 larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    51 white prepupae new    51 white prepupae 12hr    50 white prepupae 24hr    52 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day    35 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    73 embryo 04-06hr    102 embryo 06-08hr    70 embryo 08-10hr    76 embryo 10-12hr    52 embryo 12-14hr    98 embryo 14-16hr    25 embryo 16-18hr    38 embryo 18-20hr    21 embryo 20-22hr    37 embryo 22-24hr    49 larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    51 white prepupae new    51 white prepupae 12hr    50 white prepupae 24hr    52 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day    35 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr  (73) embryo 04-06hr  (102) embryo 06-08hr  (70) embryo 08-10hr  (76) embryo 10-12hr  (52) embryo 12-14hr  (98) embryo 14-16hr    25 embryo 16-18hr  (38) embryo 18-20hr    21 embryo 20-22hr  (37) embryo 22-24hr  (49) larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (51) white prepupae new  (51) white prepupae 12hr  (50) white prepupae 24hr  (52) pupae 2d postWPP  (42) pupae 3d postWPP  29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day  (35) adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    73 embryo 04-06hr  102 embryo 06-08hr    70 embryo 08-10hr    76 embryo 10-12hr    52 embryo 12-14hr    98 embryo 14-16hr    25 embryo 16-18hr    38 embryo 18-20hr    21 embryo 20-22hr    37 embryo 22-24hr    49 larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    51 white prepupae new    51 white prepupae 12hr    50 white prepupae 24hr    52 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day    35 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    73 embryo 04-06hr    102 embryo 06-08hr    70 embryo 08-10hr    76 embryo 10-12hr    52 embryo 12-14hr    98 embryo 14-16hr    25 embryo 16-18hr    38 embryo 18-20hr    21 embryo 20-22hr    37 embryo 22-24hr    49 larva L1    13 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    51 white prepupae new    51 white prepupae 12hr    50 white prepupae 24hr    52 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    11 adult male 30day    8 adult female 01day    11 adult female 05day    35 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    57 Schneider line 2 Sg4    38 embryonic 1182-4H    28 embryonic GM2    64 embryonic Kc167    56 embryonic S1    34 embryonic S3    64 leg disc CME L1    35 wing disc CME-W2    86 wing disc ML-DmD8    65 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    21 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    56 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    84 ovary fGS/OSS    29 ovary OSC    53 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (57) Schneider line 2 Sg4  (38) embryonic 1182-4H  (28) embryonic GM2  (64) embryonic Kc167  (56) embryonic S1  (34) embryonic S3  (64) leg disc CME L1  (35) wing disc CME-W2  (86) wing disc ML-DmD8  (65) wing disc ML-DmD9  (31) wing disc ML-DmD16-c3  (43) wing disc ML-DmD21    21 wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (56) eye-antennal disc ML-DmD11  (43) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (34) CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (84) ovary fGS/OSS  (29) ovary OSC  (53) ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    57 Schneider line 2 Sg4    38 embryonic 1182-4H    28 embryonic GM2    64 embryonic Kc167    56 embryonic S1    34 embryonic S3    64 leg disc CME L1    35 wing disc CME-W2    86 wing disc ML-DmD8    65 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    21 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    56 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    84 ovary fGS/OSS    29 ovary OSC    53 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    57 Schneider line 2 Sg4    38 embryonic 1182-4H    28 embryonic GM2    64 embryonic Kc167    56 embryonic S1    34 embryonic S3    64 leg disc CME L1    35 wing disc CME-W2    86 wing disc ML-DmD8    65 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    21 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    56 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    84 ovary fGS/OSS    29 ovary OSC    53 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    57 Schneider line 2 Sg4    38 embryonic 1182-4H    28 embryonic GM2    64 embryonic Kc167    56 embryonic S1    34 embryonic S3    64 leg disc CME L1    35 wing disc CME-W2    86 wing disc ML-DmD8    65 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    21 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    56 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    84 ovary fGS/OSS    29 ovary OSC    53 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (57) Schneider line 2 Sg4  (38) embryonic 1182-4H  28 embryonic GM2  (64) embryonic Kc167  (56) embryonic S1  (34) embryonic S3  (64) leg disc CME L1  (35) wing disc CME-W2  (86) wing disc ML-DmD8  (65) wing disc ML-DmD9  31 wing disc ML-DmD16-c3  (43) wing disc ML-DmD21    21 wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (56) eye-antennal disc ML-DmD11  (43) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (34) CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (84) ovary fGS/OSS  29 ovary OSC  (53) ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    57 Schneider line 2 Sg4    38 embryonic 1182-4H    28 embryonic GM2    64 embryonic Kc167    56 embryonic S1    34 embryonic S3    64 leg disc CME L1    35 wing disc CME-W2    86 wing disc ML-DmD8    65 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    21 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    56 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    84 ovary fGS/OSS    29 ovary OSC    53 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    57 Schneider line 2 Sg4    38 embryonic 1182-4H    28 embryonic GM2    64 embryonic Kc167    56 embryonic S1    34 embryonic S3    64 leg disc CME L1    35 wing disc CME-W2    86 wing disc ML-DmD8    65 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    21 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    56 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    84 ovary fGS/OSS    29 ovary OSC    53 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (32) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (28) Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010215 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17947-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4tsh-md621 α-CatGD8808 lethal | partially, with Scer\GAL4Act5C.PI α-CatScer\UAS.P\T.cMa lethal | pupal stage, with Scer\GAL4pnr-MD237 α-CatGD8808 Other Phenotypes Allele increased cell number | pupal stage, with Scer\GAL4GMR.PF α-Cat1.dsRNA.Scer\UAS neuroanatomy defective α-CatScer\UAS.T:Avic\GFP-sg visible | adult stage, with Scer\GAL4GMR.PF α-Cat1.dsRNA.Scer\UAS Phenotype manifest in Allele cone cell, with Scer\GAL4GMR.PF α-CatScer\UAS.T:Avic\GFP-sg eye | adult stage, with Scer\GAL4GMR.PF α-Cat1.dsRNA.Scer\UAS inter-ommatidial precursor cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF α-Cat1.dsRNA.Scer\UAS male genitalia, with Scer\GAL4Abd-B-LDN α-CatGD8808 male genitalia, with Scer\GAL4Myo31DF-NP1548 α-CatGD8808 tertiary pigment cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF α-Cat1.dsRNA.Scer\UAS
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of α-Cat Class Mutagen Stocks Known lesion α-CatMI02577 1 -- α-CatCPTI002342 piggyBac transposase 0 Yes α-CatCPTI002516 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of α-Cat Class Mutagen Stocks Known lesion α-CatGD8808 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes α-CatGL00636 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-CatHMS00317 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-CatHMS01903 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-CatKK107916 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-CatScer\UAS.T:Avic\GFP-sg in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes α-Cat1.dsRNA.Scer\UAS in vitro construct - regulatory fusion 0 Yes α-Cat3.dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes α-Cata.cMa in vitro construct - RNAi 0 Yes α-CatcMa in vitro construct - RNAi 0 Yes α-CatdsRNA.cYa in vitro construct - RNAi 0 Yes α-CatScer\UAS.P\T.cMa in vitro construct - regulatory fusion 0 Yes α-CatScer\UAS.T:Zzzz\eqFP578-TagRFP-T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UASp-α-Cat.M} NA P{UAS-α-Cat.T:GFP.sg} NA characterization construct P{UAS-α-Cat::shg.N} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}α-CatMI02577 NA PBac{544.SVS-1}α-CatCPTI002342 NA PBac{681.P.FSVS-1}α-CatCPTI002516 NA
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:P18824-2 (assigned by UniProtKB) (Loureiro and Peifer, 1998)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cell-cell adherens junction inferred from direct assay (Wang et al., 2006) plasma membrane inferred from direct assay (Khanna et al., 2010, Dottermusch-Heidel et al., 2012)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) cadherin binding inferred from electronic annotation with InterPro:IPR001033 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) cytoskeletal protein binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural molecule activity inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR001033, InterPro:IPR006077 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR001033, InterPro:IPR006077 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) cytoskeletal anchoring at plasma membrane inferred from sequence or structural similarity (Hynes and Zhao, 2000) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) oocyte localization involved in germarium-derived egg chamber formation traceable author statement (Deng and Lin, 2001)
Cellular Component
CV term Evidence References
actin cytoskeleton inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR001033, InterPro:IPR006077 (FlyBase Curators et al., 2004-) adherens junction non-traceable author statement (Humbert et al., 2003, Harden, 2002) catenin complex inferred from sequence or structural similarity (Hynes and Zhao, 2000) cell-substrate junction non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) spot adherens junction non-traceable author statement (Wedlich, 2002) zonula adherens non-traceable author statement (Oda, 1993, Muller, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
α-Cat - CG3476 experimental knowledge based (Guruharsha et al., 2011) α-Cat - arm anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions α-Cat allele Gene References α-CatScer\UAS.P\T.cMa Rho1 (Magie et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65744 DroID - A comprehensive database of gene and protein interactions. • FBgn0010215 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40517
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6T1J5X Dipteran inclusive ortholog search EOG64XJQT Insect inclusive ortholog search EOG6PRRKN Arthropod inclusive ortholog search EOG6SN03N Metazoa inclusive ortholog search EOG615V75
Orthologs in Drosophila Species (EOG6T1J5X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\α-Cat     Drosophila simulans   Dsim\GD12044 Y   Drosophila sechellia   Dsec\GM22485 Y   Drosophila erecta   Dere\GG16297 Y   Drosophila yakuba   Dyak\GE19475 Y   Drosophila yakuba   Dyak\GE19476     Drosophila ananassae   Dana\GF20570 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22221 Y   Drosophila persimilis   Dper\GL21877 Y   Drosophila willistoni   Dwil\GK11940 Y   Drosophila virilis   Dvir\GJ11153 Y   Drosophila mojavensis   Dmoj\GI23967 Y   Drosophila grimshawi   Dgri\α-Cat Y
Orthologs in non-Drosophila Dipterans (EOG64XJQT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003754   Anopheles gambiae Malaria mosquito  Agam\AGAP003424   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005773
Orthologs in non-Dipteran Insects (EOG6PRRKN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50135   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006410   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13911   Atta cephalotes Leafcutter ant  Acep\ACEP22708   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13136   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14085   Linepithema humile Argentine ant  Lhum\LH18193   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26128   Solenopsis invicta Red fire ant  Sinv\SINV22978   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002275   Bombyx mori Silkmoth  Bmor\BGIBMGA011888   Bombyx mori Silkmoth  Bmor\BGIBMGA011890   Pediculus humanus Human body louse  Phum\PHUM450820   Tribolium castaneum Red flour beetle  Tcas\TC004609
Orthologs in non-Insect Arthropods (EOG6SN03N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_309973   Ixodes scapularis Deer tick  Isca\ISCW022677
Orthologs in non-Arthropod Metazoa (EOG615V75)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hmp-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026137gn   Danio rerio Zebrafish  Drer\Ctnna2   Danio rerio Zebrafish  Drer\ctnna   Danio rerio Zebrafish  Drer\ctnna   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032279   Xenopus tropicalis Western clawed frog  Xtro\ctnna1   Gallus gallus Domestic chicken  Ggal\CTNNA1   Gallus gallus Domestic chicken  Ggal\CTNNA2   Gallus gallus Domestic chicken  Ggal\CTNNA3   Mus musculus House mouse  Mmus\Ctnna3   Mus musculus House mouse  Mmus\ENSMUSG00000063063   Mus musculus House mouse  Mmus\Ctnna1   Rattus norvegicus Norway rat  Rnor\Ctnna2   Rattus norvegicus Norway rat  Rnor\Ctnna1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042453   Homo sapiens Human  Hsap\CTNNA3   Homo sapiens Human  Hsap\ENSG00000066032   Homo sapiens Human  Hsap\CTNNA1
Human Orthologs (3)
Gene OMIM HGNC Hsap\CTNNA3     Hsap\ENSG00000066032     Hsap\CTNNA1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12044 Drosophila sechellia Dsec\GM22485 Drosophila erecta Dere\GG16297 Drosophila yakuba Dyak\GE19475 Drosophila ananassae Dana\GF20570 Drosophila pseudoobscura pseudoobscura Dpse\GA22221 Drosophila persimilis Dper\GL21877 Drosophila willistoni Dwil\GK11940 Drosophila virilis Dvir\GJ11153 Drosophila mojavensis Dmoj\GI23967 Drosophila grimshawi Dgri\α-Cat
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	38987 y1 v1; P{TRiP.HMS01903}attP40/CyO 35870 y1 w*; Mi{MIC}α-CatMI02577 33430 y1 sc* v1; P{TRiP.HMS00317}attP2 38197 y1 sc* v1; P{TRiP.GL00636}attP40
Kyoto	109001 w*; P{UAS-α-Cat.T:GFP.sg}3 / CyO
VDRC	v107298 P{KK107916}VIE-260B v19182 w1118; P{GD8808}v19182 v20123 w1118; P{GD8808}v20123 v40882 w1118; P{GD8808}v40882/CyO
Genomic Clones ( 2 )
	BACR22B15 BACR34K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 113 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD30423 LP08869
Other clones	FI19832
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22876 GM02796 LD04577 LD05188 LD07464 LD07667 LD14106 LD14569 LD15926 LD18130 LD18254 LD19561 LD20701 LD20893 LD27559 LD33292 LP02592 RE02278 RE04336 RE08048 RE09202 RE11106 RE11157 RE11447 RE15315 RE15988 RE18795 RE21283 RE24160 RE24492 RE24962 RE26443 RE29593 RE34591 RE35081 RE38955 RE39228 RE41422 RE43792 RE44478 RE44938 RE45029 RE48781 RE50681 RE51783 RE52570 RE54850 RE63810 RE65230 RE65270 RE66536 RE68455 RE69542 RE70623 RE72522 RE73036 RE73726 RE75160 SD06388 SD20749 SD25088
Other clones	34368 36712 37936 39632 39746 42094 59501 76856 79723 102383 125652 149486 158886 160459 173130 174604 178578 571213 CK01.103D.A8 CK01.168A.G9 CK01.168D.H4 CK01.170B.G6 Dmel_dig_000759_0697_3656 Dmel_dig_000973_0714_0337 Dmel_dig_014531_0609_0793 Dmel_neb_010551_0114_0586 Dmel_neb_011186_0682_1770 EK053206 EK103662 EK104459 EK104520 EK147135 EK148719 EK150052 EK155245 EK156323 EK159003 EK184434 EK210046 EK226034 EK255710 EK261937 EK263160 EK279356 EN06009 EN16342 FGM321C05 LD13062 RE01171
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010215 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40517
Antibody Information
	monoclonal (Oda et al., 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Multiple regions of homology in the Vinc and α-Cat sequences suggest the proteins may have overlapping functions. (Alatortsev, 1997) The binding sites for shg and α-Cat are mapped on arm protein, these bind independently of each other to arm and binding of each is required for the function of adherens junctions. (Orsulic and Peifer, 1996) Yeast two-hybrid system and in vivo assays have identified a 76 amino acid region of arm that is necessary and sufficient for binding α-Cat and also that the N-terminal 258 amino acids of α-Cat interact with arm. (Pai et al., 1996) Isolated from a genomic library, using a mouse αE-catenin cDNA as a probe, under low stringency conditions. (Oda et al., 1993) α-catenin is a component of a membrane-associated complex that includes the arm and aagp gene products. (Oda et al., 1993) α-Cat has been cloned and sequenced, and its expression pattern has been analysed. (Oda et al., 1993) The α-Cat gene product is part of a membrane-associated complex that includes the arm and aagp gene products. (Peifer, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079495 RefSeq (Proteins) • NP_524219 DDBJ / EMBL / GenBank • AA950570 AAF45466 AAK93204 AW943025 AY051780 BAA03067 D13964 Entrez Gene - A searchable database of RefSeq genes. • 40517 UniProtKB/Swiss-Prot • P35220
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Vinculin, conserved site (IPR000633) Alpha-catenin (IPR001033) Vinculin/alpha-catenin (IPR006077)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65744 DroID - A comprehensive database of gene and protein interactions. • FBgn0010215 DRSC - Results from RNAi screens. • FBgn0010215 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010215 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17947-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010215 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40517 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40517 modMine - Data generated by the modENCODE project. • FBgn0010215
Synonyms & Secondary IDs ( 34 )
Reported As
Symbol Synonym	a-cat (Coulier et al., 2000) a-Cat (Zhou et al., 2007) alpha-Cat (Greil et al., 2003, Giot et al., 2003, Bakal et al., 2007) alpha-cat (Langton et al., 2009) CG17947 (Whitfield, 2001.2.19, Whitfield, 2000.12.19, Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Khanna et al., 2010, Ni et al., 2010.12.1) CT39986 (Hynes and Zhao, 2000) Dmcatp (Alatortsev, 1997) DαC (Knox and Brown, 2002) Dα-cat (Ribeiro et al., 2004, Tepass et al., 2001, Langevin et al., 2005) Dαcat (Beronja et al., 2005) Dα-Cat (Kessler and Müller, 2009) α-Cat (Caussinus et al., 2011, Jung et al., 2006, Vidal et al., 2006, Dimitri et al., 2003, Degennaro et al., 2011, Cavey et al., 2008, Cabernard and Affolter, 2005, Seppa et al., 2008, Sarpal et al., 2012, Shindo et al., 2008) αcat (Myster et al., 2003, Van Etten, 1999, Harris and Peifer, 2004) α-cat (McCartney et al., 2001, Harris and Peifer, 2004, Andreyeva et al., 2007, Rauzi et al., 2010, Levayer et al., 2011, Gorfinkiel and Arias, 2007, Homem and Peifer, 2008, Warner and Longmore, 2009, Baer et al., 2010) α-CAT (Kramer, 2000) αCat (Simoes et al., 2006, Caussinus et al., 2008, Sawyer et al., 2009, Kaplan et al., 2009, Förster and Luschnig, 2012) αCAT (Shindo et al., 2008) α-catenin (Fernandez-Gonzalez and Zallen, 2011, Kaplan and Tolwinski, 2010) α-ctn (Magie et al., 2002)
Name Synonym	a-catenin (Zhou et al., 2007) alpha-Catenin (Dimitri et al., 2005, Wang et al., 2000) alpha-catenin (Bienz and Hamada, 2004, Oda, 1993, Gates et al., 2007, Georgiou et al., 2008, Kaido et al., 2009) alpha Catenin (Khanna et al., 2010) Dα-cadherin (Oda et al., 1996) Dα-catenin (Denholm and Skaer, 2003, Uv et al., 2003, Humbert et al., 2003, Muller, 2003, Wedlich, 2002, Yanagawa et al., 2002, Yagi and Takeichi, 2000, Yanagawa et al., 2000, Muller, 2000, Tepass, 1999, Lee et al., 1999, Oda and Tsukita, 1999, Takahashi et al., 1998, Oda et al., 1998, White et al., 1998, Martinek and Gaul, 1997, Yanagawa et al., 1997, Tepass, 1997, Oda et al., 1997, Goto and Hayashi, 1997, Tanaka-Matakatsu et al., 1996, Tepass, 1996, Fuse et al., 1996, Oda et al., 1993, Beronja et al., 2005, Iwai et al., 2002, Wang et al., 2006, Shindo et al., 2008, Paul and Beitel, 2005) DαCatenin (Mueller and Bossinger, 2003) D-α-catenin (Yanagawa et al., 1998) Dα-Catenin (Schumacher et al., 2004, Kessler and Müller, 2009) Dαcatenin (Ishihara and Sugimura, 2012) α-catenin (Lee et al., 2010, Chanut-Delalande et al., 2006, Torres et al., 2003, Polesello and Payre, 2004, Harris et al., 2004, Lopez-Schier, 2003, Perez-Moreno et al., 2003, Gonczy, 2002, Rorth, 2002, Fox et al., 2003, Akong et al., 2002, Renfranz and Beckerle, 2002, Schock and Perrimon, 2002, Deng and Lin, 2001, Cox et al., 1999, Cox et al., 1996, Kirkpatrick and Peifer, 1995, Pai et al., 1996, Orsulic and Peifer, 1996, Weis and Nelson, 2006, Pacquelet and Rorth, 2005, Montell, 2006, Desai et al., 2008, Sarpal et al., 2008, Zimmerman et al., 2008, McCaffrey et al., 2006, Muliyil et al., 2011, Meghana et al., 2011, Cliffe et al., 2004, Wodarz et al., 2006, Gorfinkiel and Arias, 2007, Homem and Peifer, 2008, Larson et al., 2008, Qin et al., 2007, Johnson et al., 2008, Goldbach et al., 2010, Martin et al., 2010, Rauzi et al., 2010, Kaplan et al., 2009, Lee and Fischer, 2012, Seppa et al., 2008, Petzoldt et al., 2012) α Catenin   αCatenin (Abrams et al., 2006, Cheshire et al., 2008, Caussinus et al., 2008) α catenin (Hoopfer et al., 2008) α-Catenin (Somers and Chia, 2005, Margolis and Borg, 2005, Rauzi et al., 2010, Xu et al., 2011, Johnson et al., 2011, Cavey et al., 2008, Seppa et al., 2008, Georgiou et al., 2008, Cordero et al., 2007, Warner and Longmore, 2009, Sekyrova et al., 2010, Simone and DiNardo, 2010, Sarpal et al., 2012) αcatenin (Haghayeghi et al., 2010)
Secondary FlyBase IDs
	FBan0017947
References ( 211 )
Generate a list of	All references relating to this gene ( 211 )
List References by type	Research paper  ( 119 ) Supplementary material  ( 11 ) Review  ( 47 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 17 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 16 )
	Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Dottermusch-Heidel et al., 2012, Dev. Biol. 368(1): 18--27 The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. [FBrf0218661] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Ishihara and Sugimura, 2012, J. Theor. Biol. 313: 201--211 Bayesian inference of force dynamics during morphogenesis. [FBrf0219571] Lee and Fischer, 2012, PLoS ONE 7(9): e46357 Drosophila Tel2 Is Expressed as a Translational Fusion with EpsinR and Is a Regulator of Wingless Signaling. [FBrf0219532] Petzoldt et al., 2012, Development 139(10): 1874--1884 DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment. [FBrf0218056] Sarpal et al., 2012, J. Cell Sci. 125(1): 233--245 Mutational analysis supports a core role for Drosophila α-Catenin in adherens junction function. [FBrf0217336] Caussinus et al., 2011, Nat. Struct. Mol. Biol. 19(1): 117--121 Fluorescent fusion protein knockout mediated by anti-GFP nanobody. [FBrf0217163] Degennaro et al., 2011, Dev. Cell 20(2): 233--243 Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion. [FBrf0212971] Fernandez-Gonzalez and Zallen, 2011, Phys. Biol. 8(4): 045005 Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. [FBrf0214479] Johnson et al., 2011, Mol. Biol. Cell 22(23): 4513--4526 Role for a Cindr-Arf6 axis in patterning emerging epithelia. [FBrf0216708] Levayer et al., 2011, Nat. Cell Biol. 13(5): 529--540 Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. [FBrf0213654] Meghana et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(22): 9107--9112 Integrin adhesion drives the emergent polarization of active cytoskeletal stresses to pattern cell delamination. [FBrf0213829] Muliyil et al., 2011, Development 138(14): 3043--3054 Spatial, temporal and molecular hierarchies in the link between death, delamination and dorsal closure. [FBrf0215259] Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Xu et al., 2011, Development 138(24): 5415--5427 Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin. [FBrf0216741] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...