FlyBase Gene Report: Dmel\Gαf

General Information

Symbol

Dmel\Gαf

Species

D. melanogaster

Name

G protein alpha subunit f

Annotation Symbol

CG12232

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010223

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

G protein α f subunit (Gαf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Gα73B, Galpha73B, Gfα, Gf

Key Links

Genomic Location

Cytogenetic map

73B5-73B5

Sequence location

3L:16,662,557..16,667,934 [-]

Recombination map

3-44

RefSeq locus

NT_037436 REGION:16662557..16667934

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables G protein-coupled receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(GO Reference Genome Project, 2011-)

enables G-protein beta/gamma-subunit complex binding

inferred from electronic annotation with InterPro:IPR001019

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(GO Reference Genome Project, 2011-)

enables GTPase activity

inferred from electronic annotation with InterPro:IPR001019

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(GO Reference Genome Project, 2011-)

enables guanyl nucleotide binding

inferred from electronic annotation with InterPro:IPR001019

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in mesoderm development

inferred from expression pattern

(Furlong et al., 2001)

involved_in positive regulation of hemocyte proliferation

inferred from genetic interaction with FLYBASE:hop; FB:FBgn0004864

(Bina et al., 2010)

involved_in regulation of filopodium assembly

inferred from mutant phenotype

(Bausek and Zeidler, 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating dopamine receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000812000

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR001019

(InterPro Project Members, 2004-)

involved_in sensory perception of chemical stimulus

inferred from biological aspect of ancestor with PANTHER:PTN000026754

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR011025

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(GO Reference Genome Project, 2011-)

part_of heterotrimeric G-protein complex

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS

Protein Family (UniProt)

Belongs to the G-alpha family. (Q05337)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Snapshot

G protein α f subunit (Gαf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS -: The Heterotrimeric G-protein alpha subunits (Gα) can bind guanine nucleotide. When inactive, Gα is bound to GDP and associates with Gβγ forming an heterotrimer. Upon GTP binding, Gα dissociates from the heterotrimer Gαβγ. Gα has an intrinsic guanosine triphosphatase (GTPase) activity. (Adapted from FBrf0209904 and FBrf0183798).

Protein Function (UniProtKB)

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

(UniProt, Q05337)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gαf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q05337)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gαf-RA

FBtr0075354

NM_079394

1825

399

Additional Transcript Data and Comments

Reported size (kB)

2.0 (northern blot)

(Quan et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gαf-PA

FBpp0075113

46.2

399

6.51

Q05337

NP_524118

AAF49429

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

399 (aa); 46 (kD)

(Quan et al., 1993)

Comments

Defines a new family of Gα proteins.

(Quan et al., 1993)

External Data

Subunit Structure (UniProtKB)

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

(UniProt, Q05337)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q05337

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαf using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Galphaf_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.30

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval posterior midgut

(Quan et al., 1993)

amnioserosa

(Quan et al., 1993)

adult stage & oogenesis

oocyte

(Quan et al., 1993)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval anterior midgut

(Quan et al., 1993)

gastric caecum

(Quan et al., 1993)

adult stage & oogenesis

nurse cell

(Quan et al., 1993)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Boto et al., 2010)

third segment of antenna

(Boto et al., 2010)

antenna

(Yao and Carlson, 2010)

labellum

(Bredendiek et al., 2011)

adult stage | male

testis

(McGurk et al., 2008)

Additional Descriptive Data

RT-PCR analysis shows that Gα73B transcript is expressed in the adult head and third segment of the antenna.

(Boto et al., 2010)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gαf in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gαf

View exonic expression by tissue for Dmel\Gαf

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39861/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010223

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010223

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010223

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12232

Flygut - An atlas of the Drosophila adult midgut

FBgn0010223

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gαf

Transgenic constructs containing regulatory region of Gαf

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)Exel6130

(Ryder, 2004.4.26)

Df(3L)Gαf^4B7

(Bausek and Zeidler, 2014)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal

Gαf^c05874

partially lethal (with Gαf^4B7)

Gαf^c05874

partially lethal (with Gαf^c05874)

Gαf^4B7

viable

Gαf^c05874

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gαf^GD7540

viable, with Scer\GAL4^Mef2.PR

Gαf^GD7540

viable, with Scer\GAL4^pnr-MD237

Gαf^GD7540

viable, with Scer\GAL4^tin.CΔ4

Gαf^GD7540

Sterility

Allele

fertile

Gαf^c05874

Phenotype manifest in

Allele

embryonic/larval hemocyte | third instar larval stage

Gαf^4B7

filopodium

Gαf^4B7

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\GNAL

5 of 14

Yes

Hsap\GNAS

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Gna11

4 of 14

Yes

Rnor\Gna13

4 of 14

Yes

Rnor\Gna14

4 of 14

Yes

Rnor\Gna15

4 of 14

Yes

Rnor\Gnai2

4 of 14

Yes

Rnor\Gnai3

4 of 14

Yes

Rnor\Gnal

4 of 14

Yes

Rnor\Gnat1

4 of 14

Yes

Rnor\Gnat2

4 of 14

Yes

Rnor\Gnat3

4 of 14

Yes

Rnor\Gnaz

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Mus musculus (laboratory mouse) (16)

Mmus\Gnal

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Xenopus tropicalis (Western clawed frog) (23)

Xtro\gna13

2 of 13

Yes

Xtro\gna15

2 of 13

Yes

Xtro\gnai3

2 of 13

Yes

Xtro\gnao1

2 of 13

Yes

Xtro\gnaq

2 of 13

Yes

Xtro\gnas

2 of 13

Yes

Xtro\gnat1

2 of 13

Yes

Xtro\gnat2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (29)

Drer\gnal

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\gna15.2

2 of 14

Yes

Drer\gnao1a

2 of 14

Drer\gna15.3

1 of 14

Drer\gnal2

1 of 14

Yes

Drer\si:ch211-207c7.2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (26)

Cele\gsa-1

5 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\sar-1

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP006521

12 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\GP ALPHA 1

4 of 13

Yes

Atha\XLG1

4 of 13

Yes

Atha\XLG2

4 of 13

Yes

Atha\XLG3

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\GPA2

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\gpa2

2 of 12

Yes

Spom\gpa1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gαf. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

CG17760

5 of 13

cta

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

1 of 13

dnd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 9 )

Human Ortholog

Disease

Evidence

References

GNAL; G protein subunit alpha L

model of dystonia 25

IEA

(FlyBase, 2019-)

GNAS; GNAS complex locus

model of pseudohypoparathyroidism type 1C

IEA

(FlyBase, 2019-)

model of ACTH-independent macronodular adrenal hyperplasia 1

IEA

(FlyBase, 2019-)

model of pseudohypoparathyroidism type 1B

IEA

(FlyBase, 2019-)

model of pituitary adenoma 3

IEA

(FlyBase, 2019-)

model of pseudopseudohypoparathyroidism

IEA

(FlyBase, 2019-)

model of progressive osseous heteroplasia

IEA

(FlyBase, 2019-)

model of McCune Albright syndrome

IEA

(FlyBase, 2019-)

model of pseudohypoparathyroidism type 1A

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

Gαf^c05874

ameliorates hematologic cancer

modeled by hop^Tum

(Bausek and Zeidler, 2014)

modeled by hop^T42

(Bausek and Zeidler, 2014)

Gαf^GD7540

ameliorates hematologic cancer

modeled by hop^Tum

(Bina et al., 2010)

Gαf^4B7

ameliorates hematologic cancer

modeled by hop^T42

(Bausek and Zeidler, 2014)

Gαf^UAS.cBa

exacerbates hematologic cancer

modeled by hop^Tum

(Bausek and Zeidler, 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GNAL; G protein subunit alpha L

5 of 14

139312

DYSTONIA 25; DYT25

dystonia 25

GNAS; GNAS complex locus

5 of 14

139320

GNA11; G protein subunit alpha 11

4 of 14

139313

GNA12; G protein subunit alpha 12

4 of 14

604394

GNA13; G protein subunit alpha 13

4 of 14

604406

GNA14; G protein subunit alpha 14

4 of 14

604397

GNA15; G protein subunit alpha 15

4 of 14

139314

GNAI2; G protein subunit alpha i2

4 of 14

139360

VENTRICULAR TACHYCARDIA, FAMILIAL

GNAI3; G protein subunit alpha i3

4 of 14

139370

AURICULOCONDYLAR SYNDROME 1; ARCND1

GNAQ; G protein subunit alpha q

4 of 14

600998

GNAT1; G protein subunit alpha transducin 1

4 of 14

139330

GNAT2; G protein subunit alpha transducin 2

4 of 14

139340

ACHROMATOPSIA 4; ACHM4

achromatopsia 4

GNAT3; G protein subunit alpha transducin 3

4 of 14

139395

GNAZ; G protein subunit alpha z

4 of 14

139160

GNAI1; G protein subunit alpha i1

3 of 14

139310

NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES; NEDHISB

GNAO1; G protein subunit alpha o1

3 of 14

139311

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hop

suppressible

Gαf

(Bausek and Zeidler, 2014, Bina et al., 2010)

hop

enhanceable

Gαf

(Bausek and Zeidler, 2014)

pbl

suppressible

Gαf

(Gregory et al., 2007)

External Data

Subunit Structure (UniProtKB)

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

(UniProt, Q05337 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010223

MIST (genetic) - An integrated Molecular Interaction Database

39861

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-44

Cytogenetic map

73B5-73B5

Sequence location

3L:16,662,557..16,667,934 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

73B5-73B5

Limits computationally determined from genome sequence between P{PZ}Baldspot⁰²²⁸¹ and P{PZ}blot⁰¹⁶⁵⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

73B-73B

(Quan, 1993.7.13)

73B-73B

(determined by in situ hybridisation)

(Quan et al., 1993)

Experimentally Determined Recombination Data

Location

3-44

(FlyBase, 2016)

3-39.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

71763

w¹¹¹⁸; P{VT031884-GAL4.DBD}attP2

29157

w¹¹¹⁸; Mi{ET1}Gαf^MB10810

25930

y¹ v¹; P{TRiP.JF01950}attP2

43201

y¹ sc^* v¹ sev²¹; P{TRiP.GL01545}attP40

Korea

13762

P{VT031884-GAL4}attP2

Kyoto

204462

y¹ w^67c23; P{GSV6}Gαf^GS13032/TM3, Sb¹ Ser¹

12232R-1

12232R-3

v17054

w¹¹¹⁸; P{GD7540}v17054

v17056

w¹¹¹⁸; P{GD7540}v17056

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP05652

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010223

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010223

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of Gα73B in the hh signalling pathway.

(Lum, 2003)

A cDNA coding for this Gα subunit isolated by PCR with degenerate oligonucleotide primers from early pupal poly(A)⁺ RNA.

(Quan et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Gαf Gα73B

(FlyBase, 2009-)

Nomenclature comments

Genes encoding Gα subunits that have been named for their molecular function/orthology have had their symbols and names standardized following the format used in FBrf0220456, which also reflects popular usage in the Drosophila literature.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG12232

(Hanlon and Andrew, 2015, Boto et al., 2010, Ni et al., 2010.12.1, Perkins et al., 2009.1.15, Colicelli, 2004)

G_f

(Boto et al., 2010)

GNAS/L

(Krishnan et al., 2015)

Galpha73B

(Franz et al., 2017, Riveron et al., 2013, Gregory et al., 2007, Martin et al., 2005, Lum, 2003, Furlong et al., 2001)

Galpha73b

(Doiguchi et al., 2016)

(Boto et al., 2010, Boto et al., 2007)

Gfalpha

(Quan, 1993.7.13)

Gfα

(Hanlon and Andrew, 2015, Bredendiek et al., 2011, Quan et al., 1993)

Gα73B

(Hanlon and Andrew, 2015, Im et al., 2015, Bausek and Zeidler, 2014, Bina et al., 2010, Yao and Carlson, 2010, McGurk et al., 2008, Yi et al., 2007, Zhang et al., 2007)

Gα_f73B

(Vecsey et al., 2014)

Gαf

(Li et al., 2021, Hanlon and Andrew, 2015)

Name Synonyms

G protein alpha subunit f

G protein α 73B

G protein α f subunit

GTP-binding protein alpha-subunit

(Quan, 1993.7.13)

Gf alpha

(Jung et al., 2007)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39861

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q05337

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q05337

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q05337

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39861/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010223

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010223

FlyMine - An integrated database for Drosophila genomics

FBgn0010223

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12232

MARRVEL_MODEL - MARRVEL (model organism gene)

39861

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010223

DroID - A comprehensive database of gene and protein interactions.

FBgn0010223

DRSC - Results frm RNAi screens

FBgn0010223

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Galphaf_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010223

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010223

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12232

Flygut - An atlas of the Drosophila adult midgut

FBgn0010223

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010223

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009809

MIST (genetic) - An integrated Molecular Interaction Database

39861

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (57)

The following external sites may use different assemblies or annotations than FlyBase.

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