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Gene Dmel\Gel

General Information
Symbol	Dmel\Gel	Species	D. melanogaster
Name	Gelsolin	Annotation symbol	CG1106
Feature type	protein_coding_gene	FlyBase ID	FBgn0010225
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82A1-82A1	Sequence location	3R:60,939..66,780 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gelsolin is referred to in FlyBase by the symbol Dmel\Gel (CG1106, FBgn0010225). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 7 alleles are reported. The phenotypes of these alleles are annotated with: mitochondrion; adult brain. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Gelsolin domain; Villin/Gelsolin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout the larval period, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval/adult salivary gland, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1627060_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Gel. Gene sequence location is 3R:60939..66780.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82A1-82A1   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82A-82B   (determined by in situ hybridisation)   (Heintzelman et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gel for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.48 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gel-RA FBtr0078971  NM_164319   2629   740 Gel-RB FBtr0078968  NM_080126   2837   798 Gel-RD FBtr0078969  NM_164321   2941   798 Gel-RF FBtr0078973  NM_176394   2808   798 Gel-RJ FBtr0309256  NM_206427   2898   798 Gel-RK FBtr0309257  NM_206426   2840   786 Gel-RL FBtr0336707  NM_001043192   2585   740
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gel-PA   FBpp0078610   82.5   740   4.65     NP_730788   AAF52162 Gel-PB   FBpp0078607   88.4   798   4.71     NP_524865   AAF52163 Gel-PD   FBpp0078608   88.4   798   4.71     NP_730790   AAF52164 Gel-PF   FBpp0078612   88.4   798   4.71     NP_788571   AAO41510 Gel-PJ   FBpp0301195   88.4   798   4.71     NP_996149   AAO41509 Gel-PK   FBpp0301196   87.4   786   4.73     NP_996148   AAN13333 Gel-PL   FBpp0307688   82.5   740   4.65     NP_001036657   ABI31119
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Villin/Gelsolin (IPR007122) Gelsolin domain (IPR007123)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539495   AA698342   AA698358   AA698634   AA801545   AE014297 AAF52162   AE014297 AAF52163   AE014297 AAF52164   AE014297 AAN13333   AE014297 AAO41509   AE014297 AAO41510   AE014297 ABI31119   AI062234   AI063180   AI063686   AI064264   AI106644   AI107077   AI107718   AI107802   AI113389   AI113443   AI134167   AI135036   AI238270   AI259383   AI260652   AI293682   AI293867   AI294520   AI296757   AI296961   AI297053   AI297506   AI387928   AI388565   AI389058   AI403608   AI404126   AI404539   AI404618   AI404621   AI406083   AI513531   AI513709   AI514044   AI514452   AI514974   AI516863   AI517141   AI530803   AI531561   AI531589   AI532277   AI532278   AI532684   AI533017   AI533147   AI534589   AI541653   AI542134   AI542741   AI542853   AI542963   AI543706   AW944505   AY119662 AAM50316   BF486750   BF488408   BF488595   BF490906   BF491622   BF504280   BG631955   BG633477   BG635428   BG636466   BG636544   BG637118   BG640122   BG641073   BG641128   BI172682   BI172971   BI173525   BI173881   BI215215   BI362903   BI365157   BI368973   BI368994   BI370972   BI483904   BI485081   BI564467   BI564863   BI568315   BI568339   BI568865   BI571013   BI571738   BI572119   BI572162   BI572401   BI572645   BI575701   BI576986   BI588978   BI590895   BI591079   BI591147   BI591712   BI591878   BI592524   BI592760   BI593292   BI610321   BI610834   BI612484   BI615794   BI616651   BI617749   BI618518   BI619703   BI623505   BI626609   BI627625   BI629891   BI633881   BI634835   BI635212   BI636539   BI636732   BI637689   BI637873   BI639313   BI639497   BI640087   BI641086   BP541784   BT022413   BT022458   BT031288   CA804396   CA806528   CA806894   CA806899   CA806928   CA807248   CA807806   CK131645   CK132358   CK132437   CK445216   CK656973   CK657646   CK658170   CK658314   CK658572   CK658664   CK660674   CK660937   CO154926   CO155771   CO180929   CO186889   CO191469   CO191764   CO193048   CO195259   CO264022   CO268146   CO268274   CO270968   CO277664   CO277698   CO278357   CO278386   CO292785   CO297757   CO301538   CO304627   CO306492   CO318287   CO319170   CO321637   CO322048   CO325798   CO328136   CO336987   EC062962   EC075510   EC077066   EC078482   EC079438   EC085887   EC087000   EC225440   EC225441   EC235630   EC250099   EC257732   EC264687   EC265143   EC265449   EC265716   ES691829   ES695194   GH941343   GH944265   GH945581   GH945786   GH946554   GH947289   GH949288   GH949321   GH950096   GH950316   GH950690   GH950953   GH951143   GH951180   GH951790   GH953889   GH957358   GH957679   GH957990   GH958008   GH958020   GH958175   GH959127   GH966629   GH966979   GH968073   GH970160   GH970744   GH971317   GH971551   GH973467   GH974012   GH974098   GH974794   GH975631   GH976792   GH977014   GH977015   GH977861   GH981944   GH982747   GH983230   GH984163   L08794 AAA28568   X75629 CAA53294   X75630 CAA53295
UniProtKB/Swiss-Prot	Q07171
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) esophageal visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
actin filament inferred from direct assay (Stella et al., 1994) cytosol inferred from direct assay (Stella et al., 1994) extracellular region inferred from direct assay (Stella et al., 1994, Karlsson et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval/adult salivary gland, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut    1199.9 Larval Malpighian Tubules    1594.6 Larval Fat Body    6652.4 Larval Salivary Gland    268 Larval Trachea    549.825 Larval Carcass    879.5 Adult Head    2187.3 Adult Eye    1397.025 Adult Brain    794.6 Adult Thoracic-Abdominal Ganglion    785.8 Adult Crop    1501.5 Adult Midgut    218.2 Adult Hindgut    902.8 Adult Malpighian Tubules    1226.6 Adult Fat Body    3245.6 Adult Salivary Gland    204 Adult Heart    2679.025 Adult VirginFemale Spermatheca    3569.5 Adult InseminatedFemale Spermatheca    3039.7 Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass    2416.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut  (1199.9) Larval Malpighian Tubules  (1594.6) Larval Fat Body  (6652.4) Larval Salivary Gland    268 Larval Trachea  (549.825) Larval Carcass  (879.5) Adult Head  (2187.3) Adult Eye  (1397.025) Adult Brain  (794.6) Adult Thoracic-Abdominal Ganglion  (785.8) Adult Crop  (1501.5) Adult Midgut    218.2 Adult Hindgut  (902.8) Adult Malpighian Tubules  (1226.6) Adult Fat Body  (3245.6) Adult Salivary Gland    204 Adult Heart  (2679.025) Adult VirginFemale Spermatheca  (3569.5) Adult InseminatedFemale Spermatheca  (3039.7) Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass  (2416.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut  (1199.9) Larval Malpighian Tubules  (1594.6) Larval Fat Body  (6652.4) Larval Salivary Gland    268 Larval Trachea    549.825 Larval Carcass    879.5 Adult Head  (2187.3) Adult Eye  (1397.025) Adult Brain    794.6 Adult Thoracic-Abdominal Ganglion    785.8 Adult Crop  (1501.5) Adult Midgut    218.2 Adult Hindgut    902.8 Adult Malpighian Tubules  (1226.6) Adult Fat Body  (3245.6) Adult Salivary Gland    204 Adult Heart  (2679.025) Adult VirginFemale Spermatheca  (3569.5) Adult InseminatedFemale Spermatheca  (3039.7) Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass  (2416.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut    1199.9 Larval Malpighian Tubules    1594.6 Larval Fat Body    6652.4 Larval Salivary Gland    268 Larval Trachea    549.825 Larval Carcass    879.5 Adult Head    2187.3 Adult Eye    1397.025 Adult Brain    794.6 Adult Thoracic-Abdominal Ganglion    785.8 Adult Crop    1501.5 Adult Midgut    218.2 Adult Hindgut    902.8 Adult Malpighian Tubules    1226.6 Adult Fat Body    3245.6 Adult Salivary Gland    204 Adult Heart    2679.025 Adult VirginFemale Spermatheca    3569.5 Adult InseminatedFemale Spermatheca    3039.7 Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass    2416.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut    1199.9 Larval Malpighian Tubules    1594.6 Larval Fat Body    6652.4 Larval Salivary Gland    268 Larval Trachea    549.825 Larval Carcass    879.5 Adult Head    2187.3 Adult Eye    1397.025 Adult Brain    794.6 Adult Thoracic-Abdominal Ganglion    785.8 Adult Crop    1501.5 Adult Midgut    218.2 Adult Hindgut    902.8 Adult Malpighian Tubules    1226.6 Adult Fat Body    3245.6 Adult Salivary Gland    204 Adult Heart    2679.025 Adult VirginFemale Spermatheca    3569.5 Adult InseminatedFemale Spermatheca    3039.7 Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass    2416.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut  (1199.9) Larval Malpighian Tubules  (1594.6) Larval Fat Body  (6652.4) Larval Salivary Gland    268 Larval Trachea  549.825 Larval Carcass  (879.5) Adult Head  (2187.3) Adult Eye  (1397.025) Adult Brain  794.6 Adult Thoracic-Abdominal Ganglion  785.8 Adult Crop  (1501.5) Adult Midgut    218.2 Adult Hindgut  (902.8) Adult Malpighian Tubules  (1226.6) Adult Fat Body  (3245.6) Adult Salivary Gland    204 Adult Heart  (2679.025) Adult VirginFemale Spermatheca  (3569.5) Adult InseminatedFemale Spermatheca  (3039.7) Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass  (2416.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut  1199.9 Larval Malpighian Tubules  1594.6 Larval Fat Body  (6652.4) Larval Salivary Gland    268 Larval Trachea    549.825 Larval Carcass    879.5 Adult Head  (2187.3) Adult Eye  1397.025 Adult Brain    794.6 Adult Thoracic-Abdominal Ganglion    785.8 Adult Crop  1501.5 Adult Midgut    218.2 Adult Hindgut    902.8 Adult Malpighian Tubules  1226.6 Adult Fat Body  (3245.6) Adult Salivary Gland    204 Adult Heart  (2679.025) Adult VirginFemale Spermatheca  (3569.5) Adult InseminatedFemale Spermatheca  (3039.7) Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass  (2416.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    207.6 Larval Midgut    169.4 Larval Hindgut    1199.9 Larval Malpighian Tubules    1594.6 Larval Fat Body    6652.4 Larval Salivary Gland    268 Larval Trachea    549.825 Larval Carcass    879.5 Adult Head    2187.3 Adult Eye    1397.025 Adult Brain    794.6 Adult Thoracic-Abdominal Ganglion    785.8 Adult Crop    1501.5 Adult Midgut    218.2 Adult Hindgut    902.8 Adult Malpighian Tubules    1226.6 Adult Fat Body    3245.6 Adult Salivary Gland    204 Adult Heart    2679.025 Adult VirginFemale Spermatheca    3569.5 Adult InseminatedFemale Spermatheca    3039.7 Adult Ovary    36.4 Adult Testis    114.8 Adult Male Accessory Gland    198.7 Adult Carcass    2416.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2187.3   NA  Eye    1397.025   NA  Brain    794.6   207.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    785.8   NA  Crop    1501.5   169.4  Midgut    218.2   1199.9  Hindgut    902.8   1594.6  Malpighian Tubules    1226.6   6652.4  Fat Body    3245.6   268  Salivary Gland    204   NA  Heart    2679.025   549.825  Trachea    NA   NA  VirginFemale Spermatheca    3569.5   NA  InseminatedFemale Spermatheca    3039.7   NA  Ovary    36.4   NA  Testis    114.8   NA  Male Accessory Gland    198.7   879.5  Carcass    2416.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    29 central nervous system, pupae P8    18 head, virgin 1-day female    116 head, virgin 4-day female    157 head, virgin 20-day female    359 head, mated 1-day female    93 head, mated 4-day female    178 head, mated 20-day female    261 head, mated 1-day male    164 head, mated 4-day male    259 head, mated 20-day male    387 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    86 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering    477 fat body, white prepupae    265 fat body, pupae P8    48 carcass, larvae L3 wandering    169 carcass, 1-day adult    139 carcass, 4-day adult    155 carcass, 20-day adult    224 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3  (29) central nervous system, pupae P8    18 head, virgin 1-day female  (116) head, virgin 4-day female  (157) head, virgin 20-day female  (359) head, mated 1-day female  (93) head, mated 4-day female  (178) head, mated 20-day female  (261) head, mated 1-day male  (164) head, mated 4-day male  (259) head, mated 20-day male  (387) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae  (86) digestive system, larvae L3 wandering  (81) digestive system, 1-day adult  (29) digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (477) fat body, white prepupae  (265) fat body, pupae P8  (48) carcass, larvae L3 wandering  (169) carcass, 1-day adult  (139) carcass, 4-day adult  (155) carcass, 20-day adult  (224) ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    29 central nervous system, pupae P8    18 head, virgin 1-day female  (116) head, virgin 4-day female  (157) head, virgin 20-day female  (359) head, mated 1-day female    93 head, mated 4-day female  (178) head, mated 20-day female  (261) head, mated 1-day male  (164) head, mated 4-day male  (259) head, mated 20-day male  (387) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    86 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (477) fat body, white prepupae  (265) fat body, pupae P8    48 carcass, larvae L3 wandering  (169) carcass, 1-day adult  (139) carcass, 4-day adult  (155) carcass, 20-day adult  (224) ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    29 central nervous system, pupae P8    18 head, virgin 1-day female    116 head, virgin 4-day female    157 head, virgin 20-day female    359 head, mated 1-day female    93 head, mated 4-day female    178 head, mated 20-day female    261 head, mated 1-day male    164 head, mated 4-day male    259 head, mated 20-day male    387 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    86 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering    477 fat body, white prepupae    265 fat body, pupae P8    48 carcass, larvae L3 wandering    169 carcass, 1-day adult    139 carcass, 4-day adult    155 carcass, 20-day adult    224 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    29 central nervous system, pupae P8    18 head, virgin 1-day female    116 head, virgin 4-day female    157 head, virgin 20-day female    359 head, mated 1-day female    93 head, mated 4-day female    178 head, mated 20-day female    261 head, mated 1-day male    164 head, mated 4-day male    259 head, mated 20-day male    387 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    86 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering    477 fat body, white prepupae    265 fat body, pupae P8    48 carcass, larvae L3 wandering    169 carcass, 1-day adult    139 carcass, 4-day adult    155 carcass, 20-day adult    224 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3  29 central nervous system, pupae P8    18 head, virgin 1-day female  (116) head, virgin 4-day female  (157) head, virgin 20-day female  (359) head, mated 1-day female  (93) head, mated 4-day female  (178) head, mated 20-day female  (261) head, mated 1-day male  (164) head, mated 4-day male  (259) head, mated 20-day male  (387) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae  (86) digestive system, larvae L3 wandering  (81) digestive system, 1-day adult  29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (477) fat body, white prepupae  (265) fat body, pupae P8  (48) carcass, larvae L3 wandering  (169) carcass, 1-day adult  (139) carcass, 4-day adult  (155) carcass, 20-day adult  (224) ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    29 central nervous system, pupae P8    18 head, virgin 1-day female  116 head, virgin 4-day female  (157) head, virgin 20-day female  (359) head, mated 1-day female    93 head, mated 4-day female  (178) head, mated 20-day female  (261) head, mated 1-day male  (164) head, mated 4-day male  (259) head, mated 20-day male  (387) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    86 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (477) fat body, white prepupae  (265) fat body, pupae P8    48 carcass, larvae L3 wandering  (169) carcass, 1-day adult  139 carcass, 4-day adult  (155) carcass, 20-day adult  (224) ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    29 central nervous system, pupae P8    18 head, virgin 1-day female    116 head, virgin 4-day female    157 head, virgin 20-day female    359 head, mated 1-day female    93 head, mated 4-day female    178 head, mated 20-day female    261 head, mated 1-day male    164 head, mated 4-day male    259 head, mated 20-day male    387 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    86 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    29 digestive system, 4-day adult    19 digestive system, 20-day adult    19 fat body, larvae L3 wandering    477 fat body, white prepupae    265 fat body, pupae P8    48 carcass, larvae L3 wandering    169 carcass, 1-day adult    139 carcass, 4-day adult    155 carcass, 20-day adult    224 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    17 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout the larval period, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    33 embryo 12-14hr    33 embryo 14-16hr    62 embryo 16-18hr    91 embryo 18-20hr    88 embryo 20-22hr    78 embryo 22-24hr    84 larva L1    77 larva L2    107 larva L3 12hr old    182 larva L3 puffstage 1-2    198 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    205 white prepupae new    251 white prepupae 12hr    171 white prepupae 24hr    148 pupae 2d postWPP    126 pupae 3d postWPP    86 pupae 4d postWPP    58 adult male 01day    89 adult male 05day    77 adult male 30day    58 adult female 01day    47 adult female 05day    45 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr  (33) embryo 12-14hr  (33) embryo 14-16hr  (62) embryo 16-18hr  (91) embryo 18-20hr  (88) embryo 20-22hr  (78) embryo 22-24hr  (84) larva L1  (77) larva L2  (107) larva L3 12hr old  (182) larva L3 puffstage 1-2  (198) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (205) white prepupae new  (251) white prepupae 12hr  (171) white prepupae 24hr  (148) pupae 2d postWPP  (126) pupae 3d postWPP  (86) pupae 4d postWPP  (58) adult male 01day  (89) adult male 05day  (77) adult male 30day  (58) adult female 01day  (47) adult female 05day  (45) adult female 30day  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    33 embryo 12-14hr    33 embryo 14-16hr    62 embryo 16-18hr    91 embryo 18-20hr    88 embryo 20-22hr    78 embryo 22-24hr    84 larva L1    77 larva L2  107 larva L3 12hr old  (182) larva L3 puffstage 1-2  (198) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (205) white prepupae new  (251) white prepupae 12hr  (171) white prepupae 24hr  (148) pupae 2d postWPP  (126) pupae 3d postWPP    86 pupae 4d postWPP    58 adult male 01day    89 adult male 05day    77 adult male 30day    58 adult female 01day    47 adult female 05day    45 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    33 embryo 12-14hr    33 embryo 14-16hr    62 embryo 16-18hr    91 embryo 18-20hr    88 embryo 20-22hr    78 embryo 22-24hr    84 larva L1    77 larva L2    107 larva L3 12hr old    182 larva L3 puffstage 1-2    198 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    205 white prepupae new    251 white prepupae 12hr    171 white prepupae 24hr    148 pupae 2d postWPP    126 pupae 3d postWPP    86 pupae 4d postWPP    58 adult male 01day    89 adult male 05day    77 adult male 30day    58 adult female 01day    47 adult female 05day    45 adult female 30day    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    33 embryo 12-14hr    33 embryo 14-16hr    62 embryo 16-18hr    91 embryo 18-20hr    88 embryo 20-22hr    78 embryo 22-24hr    84 larva L1    77 larva L2    107 larva L3 12hr old    182 larva L3 puffstage 1-2    198 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    205 white prepupae new    251 white prepupae 12hr    171 white prepupae 24hr    148 pupae 2d postWPP    126 pupae 3d postWPP    86 pupae 4d postWPP    58 adult male 01day    89 adult male 05day    77 adult male 30day    58 adult female 01day    47 adult female 05day    45 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr  (33) embryo 12-14hr  (33) embryo 14-16hr  (62) embryo 16-18hr  (91) embryo 18-20hr  (88) embryo 20-22hr  (78) embryo 22-24hr  (84) larva L1  (77) larva L2  (107) larva L3 12hr old  (182) larva L3 puffstage 1-2  (198) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (205) white prepupae new  (251) white prepupae 12hr  (171) white prepupae 24hr  (148) pupae 2d postWPP  (126) pupae 3d postWPP  (86) pupae 4d postWPP  (58) adult male 01day  (89) adult male 05day  (77) adult male 30day  (58) adult female 01day  (47) adult female 05day  (45) adult female 30day  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    33 embryo 12-14hr    33 embryo 14-16hr    62 embryo 16-18hr    91 embryo 18-20hr    88 embryo 20-22hr    78 embryo 22-24hr    84 larva L1    77 larva L2  107 larva L3 12hr old  (182) larva L3 puffstage 1-2  (198) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (205) white prepupae new  (251) white prepupae 12hr  (171) white prepupae 24hr  (148) pupae 2d postWPP  126 pupae 3d postWPP    86 pupae 4d postWPP    58 adult male 01day    89 adult male 05day    77 adult male 30day    58 adult female 01day    47 adult female 05day    45 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    8 embryo 04-06hr    11 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    33 embryo 12-14hr    33 embryo 14-16hr    62 embryo 16-18hr    91 embryo 18-20hr    88 embryo 20-22hr    78 embryo 22-24hr    84 larva L1    77 larva L2    107 larva L3 12hr old    182 larva L3 puffstage 1-2    198 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    205 white prepupae new    251 white prepupae 12hr    171 white prepupae 24hr    148 pupae 2d postWPP    126 pupae 3d postWPP    86 pupae 4d postWPP    58 adult male 01day    89 adult male 05day    77 adult male 30day    58 adult female 01day    47 adult female 05day    45 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    295 Schneider line 2 Sg4    12 embryonic 1182-4H    58 embryonic GM2    88 embryonic Kc167    87 embryonic S1    52 embryonic S3    332 leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    221 wing disc ML-DmD21    36 wing disc ML-DmD32    389 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    262 mixed discs ML-DmD4-c1    156 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    257 ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (295) Schneider line 2 Sg4    12 embryonic 1182-4H  (58) embryonic GM2  (88) embryonic Kc167  (87) embryonic S1  (52) embryonic S3  (332) leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8  (27) wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (221) wing disc ML-DmD21  (36) wing disc ML-DmD32  (389) haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5  (262) mixed discs ML-DmD4-c1  (156) CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (257) ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (295) Schneider line 2 Sg4    12 embryonic 1182-4H    58 embryonic GM2    88 embryonic Kc167    87 embryonic S1    52 embryonic S3  (332) leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3  (221) wing disc ML-DmD21    36 wing disc ML-DmD32  (389) haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5  (262) mixed discs ML-DmD4-c1  (156) CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (257) ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    295 Schneider line 2 Sg4    12 embryonic 1182-4H    58 embryonic GM2    88 embryonic Kc167    87 embryonic S1    52 embryonic S3    332 leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    221 wing disc ML-DmD21    36 wing disc ML-DmD32    389 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    262 mixed discs ML-DmD4-c1    156 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    257 ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    295 Schneider line 2 Sg4    12 embryonic 1182-4H    58 embryonic GM2    88 embryonic Kc167    87 embryonic S1    52 embryonic S3    332 leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    221 wing disc ML-DmD21    36 wing disc ML-DmD32    389 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    262 mixed discs ML-DmD4-c1    156 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    257 ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (295) Schneider line 2 Sg4    12 embryonic 1182-4H  (58) embryonic GM2  (88) embryonic Kc167  (87) embryonic S1  (52) embryonic S3  (332) leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8  27 wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (221) wing disc ML-DmD21  (36) wing disc ML-DmD32  (389) haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5  (262) mixed discs ML-DmD4-c1  (156) CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (257) ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (295) Schneider line 2 Sg4    12 embryonic 1182-4H    58 embryonic GM2    88 embryonic Kc167    87 embryonic S1    52 embryonic S3  (332) leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3  (221) wing disc ML-DmD21    36 wing disc ML-DmD32  (389) haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5  (262) mixed discs ML-DmD4-c1  (156) CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (257) ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    295 Schneider line 2 Sg4    12 embryonic 1182-4H    58 embryonic GM2    88 embryonic Kc167    87 embryonic S1    52 embryonic S3    332 leg disc CME L1    15 wing disc CME-W2    7 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    221 wing disc ML-DmD21    36 wing disc ML-DmD32    389 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    262 mixed discs ML-DmD4-c1    156 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    257 ovary fGS/OSS    13 ovary OSC    7 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    140 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    158 Ethanol 10% 3 hrs, larvae L3    133 Caffeine 1.5 mg/ml 4 hrs, larvae L3    185 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    147 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult  (75) Cadmium 50 mM 6 hrs, larvae L3  (140) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (97) Cadmium 100 mM 48 hrs, 4-day adult  (29) Copper 0.5 mM 12 hrs, larvae L3  (62) Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3  (45) Zinc 4.5 mM 48 hrs, 4-day adult  (50) Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3  (158) Ethanol 10% 3 hrs, larvae L3  (133) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (185) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (48) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3  (142) Rotenone 8 μg 12 hrs, larvae L3  (147) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3  (140) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3  (158) Ethanol 10% 3 hrs, larvae L3  (133) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (185) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3  (142) Rotenone 8 μg 12 hrs, larvae L3  (147) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    140 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    158 Ethanol 10% 3 hrs, larvae L3    133 Caffeine 1.5 mg/ml 4 hrs, larvae L3    185 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    147 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    140 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    158 Ethanol 10% 3 hrs, larvae L3    133 Caffeine 1.5 mg/ml 4 hrs, larvae L3    185 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    147 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult  (75) Cadmium 50 mM 6 hrs, larvae L3  (140) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (97) Cadmium 100 mM 48 hrs, 4-day adult  29 Copper 0.5 mM 12 hrs, larvae L3  (62) Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3  (45) Zinc 4.5 mM 48 hrs, 4-day adult  (50) Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3  (158) Ethanol 10% 3 hrs, larvae L3  (133) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (185) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (48) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3  (142) Rotenone 8 μg 12 hrs, larvae L3  (147) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3  140 Cadmium 50 mM 12 hrs, larvae L3  132 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3  (158) Ethanol 10% 3 hrs, larvae L3  133 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (185) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3  142 Rotenone 8 μg 12 hrs, larvae L3  (147) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    22 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    140 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    158 Ethanol 10% 3 hrs, larvae L3    133 Caffeine 1.5 mg/ml 4 hrs, larvae L3    185 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    147 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • PC00144 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010225 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1106-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gel Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 GelGD5130 Phenotype manifest in Allele adult brain, with Scer\GAL4elav.PU GelScer\UAS.cDa mitochondrion, with Scer\GAL4elav.PU GelScer\UAS.cDa
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Gel Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gel Class Mutagen Stocks Known lesion GelGD5130 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes GelHMS02269 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GelJF01723 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GelNIG.1106R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GelScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Gelt10.8 in vitro construct - genomic fragment 0 Yes Gelt15.6 in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)231-5 (Irion and Leptin, 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5130} NA P{NIG.1106R} NA P{TRiP.HMS02269} NA P{TRiP.JF01723} NA P{UAS-Gel.D} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
actin filament inferred from direct assay (Stella et al., 1994) cytosol inferred from direct assay (Stella et al., 1994) extracellular region inferred from direct assay (Stella et al., 1994, Karlsson et al., 2004)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with UniProtKB:P20305 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gel allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70060 DroID - A comprehensive database of gene and protein interactions. • FBgn0010225 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46008
Orthologs
OrthoDB Orthologs (66) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66HGW5 Dipteran inclusive ortholog search EOG673Q0D Insect inclusive ortholog search EOG65742H Arthropod inclusive ortholog search EOG6JM64M Metazoa inclusive ortholog search EOG67DP8K
Orthologs in Drosophila Species (EOG66HGW5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gel     Drosophila simulans   Dsim\Gel Y   Drosophila sechellia   Dsec\GM10736 Y   Drosophila erecta   Dere\GG12208 Y   Drosophila yakuba   Dyak\Gel Y   Drosophila ananassae   Dana\GF18195 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10732 Y   Drosophila persimilis   Dper\GL12306 Y   Drosophila willistoni   Dwil\GK22516 Y   Drosophila virilis   Dvir\GJ14452 Y   Drosophila mojavensis   Dmoj\GI10844 Y   Drosophila grimshawi   Dgri\GH19024 Y
Orthologs in non-Drosophila Dipterans (EOG673Q0D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006090   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006095   Anopheles gambiae Malaria mosquito  Agam\AGAP011369   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004629
Orthologs in non-Dipteran Insects (EOG65742H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI008158   Bombyx mori Silkmoth  Bmor\BGIBMGA001730   Pediculus humanus Human body louse  Phum\PHUM042690   Tribolium castaneum Red flour beetle  Tcas\TC004676
Orthologs in non-Insect Arthropods (EOG6JM64M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303199   Ixodes scapularis Deer tick  Isca\ISCW007199
Orthologs in non-Arthropod Metazoa (EOG67DP8K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gsnl-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001875gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000296gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001874gn   Danio rerio Zebrafish  Drer\zgc:136857   Danio rerio Zebrafish  Drer\gsnb   Danio rerio Zebrafish  Drer\vil1l   Danio rerio Zebrafish  Drer\scinla   Danio rerio Zebrafish  Drer\scin   Danio rerio Zebrafish  Drer\ENSDARG00000001909   Danio rerio Zebrafish  Drer\capg   Danio rerio Zebrafish  Drer\gsna   Danio rerio Zebrafish  Drer\si:ch211-114c12.4   Danio rerio Zebrafish  Drer\scinlb   Danio rerio Zebrafish  Drer\scinla   Xenopus tropicalis Western clawed frog  Xtro\capg   Xenopus tropicalis Western clawed frog  Xtro\scin   Xenopus tropicalis Western clawed frog  Xtro\gsn   Xenopus tropicalis Western clawed frog  Xtro\vil1   Xenopus tropicalis Western clawed frog  Xtro\scin   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000018663   Xenopus tropicalis Western clawed frog  Xtro\vill   Xenopus tropicalis Western clawed frog  Xtro\avil   Gallus gallus Domestic chicken  Ggal\GSN   Gallus gallus Domestic chicken  Ggal\VILL   Gallus gallus Domestic chicken  Ggal\SCIN   Gallus gallus Domestic chicken  Ggal\VIL1   Mus musculus House mouse  Mmus\Capg   Mus musculus House mouse  Mmus\Gsn   Mus musculus House mouse  Mmus\Vill   Mus musculus House mouse  Mmus\Scin   Mus musculus House mouse  Mmus\Vil1   Mus musculus House mouse  Mmus\Avil   Rattus norvegicus Norway rat  Rnor\Gsn   Rattus norvegicus Norway rat  Rnor\Scin   Rattus norvegicus Norway rat  Rnor\Vil1   Rattus norvegicus Norway rat  Rnor\Capg   Rattus norvegicus Norway rat  Rnor\Vill   Homo sapiens Human  Hsap\AVIL   Homo sapiens Human  Hsap\GSN   Homo sapiens Human  Hsap\VILL   Homo sapiens Human  Hsap\SCIN   Homo sapiens Human  Hsap\VIL1   Homo sapiens Human  Hsap\CAPG
Human Orthologs (6)
Gene OMIM HGNC Hsap\AVIL     Hsap\GSN     Hsap\VILL     Hsap\SCIN     Hsap\VIL1     Hsap\CAPG
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Gel Drosophila sechellia Dsec\GM10736 Drosophila erecta Dere\GG12208 Drosophila yakuba Dyak\Gel Drosophila ananassae Dana\GF18195 Drosophila pseudoobscura pseudoobscura Dpse\GA10732 Drosophila persimilis Dper\GL12306 Drosophila willistoni Dwil\GK22516 Drosophila virilis Dvir\GJ14452 Drosophila mojavensis Dmoj\GI10844 Drosophila grimshawi Dgri\GH19024
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	31205 y1 v1; P{TRiP.JF01723}attP2 41704 y1 sc* v1; P{TRiP.HMS02269}attP2
VDRC	v37867 w1118 P{GD5130}v37867 v37865 w1118; P{GD5130}v37865
Genomic Clones ( 1 )
	BACR15O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 240 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05617 IP05917 RE15339 SD07495
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05619 AT21267 AT23674 AT24067 AT26752 AT27538 AT28414 GH01373 GH02703 GH03637 GH04625 GH05546 GH05656 GH06369 GH06711 GH09005 GH09707 GH11547 GH12649 GH14285 GH18631 GH19517 GH20140 GH23082 GH23729 GH24287 GH24395 GH24404 GH26283 GH26656 GH26765 GH27093 GH27447 HL04309 HL04335 HL05369 HL06627 LD17652 LD40961 LD46623 LP02780 LP04604 LP06871 LP07115 LP07916 LP10827 LP11090 LP11221 LP11817 LP12553 LP13822 LP13963 LP14187 LP15160 LP15585 LP15787 LP19443 LP19911 LP22863 LP24112 RE15327 RE15689 RE16459 RE17013 RE21557 RE47585 RE50389 RE55042 RE55066 RE57760 RE66867 RE68354 RH04582 RH04787 RH04869 RH05821 RH06582 RH07022 RH07465 RH07514 RH07683 RH07905 RH08239 RH10238 RH10538 RH11291 RH15490 RH16758 RH30609 RH31487 RH33713 RH39078 RH39736 RH39765 RH41360 RH45570 RH46692 RH48175 RH49371 RH50790 RH55783 RH58826 RH61748 RH62391 RH67607 RH68982 SD01526 SD02654 SD02687 SD03728 SD03729 SD04272 SD04686 SD04872 SD05915 SD08240 SD09190 SD09348 SD09487 SD10581 SD11076 SD12315 SD12382 SD12837 SD14187 SD14281 SD14979 SD16489 SD18249 SD18540 SD19748 SD20003 SD21869 SD22079 SD22870 SD24219 SD28061
Other clones	61005 61095 72402 77776 78118 104202 121099 166629 174955 214513.48 282862 522311 524258 525560 562045 EC13185 EC31125 EC31780 EC35042 EC39944 EK024414 EK090303 EK090803 EK101215 EK125735 EK125846 EK129847 EK129935 EK137216 EK170464 EK181342 EK186059 EK187113 EK197503 EK200945 EK245333 EK251212 EK271249 EK276441 EN05039 EN06720 EN13617 EP08630 ESG013d.E21_C02 ESG015c.E21_A09 ESG015c.E21.1_B03 ESG015c.E21.1_F01 ESG017a.E21_C12 ESG019c.E21_G08 ESG0113b.B21.1_G11 FGC005D04 GH27784 LP14853 RC0-DA0001-130700-118-G08 RC0-DL0001-140700-126-D04 RH01148 RP004011904 RP004041014 RP004045268 RP004045434 RP004046103 RP004053621 RP004060200 RP004122920 RP004154093 RP004160090 RP004161942 RP004166933 RP004170077 RP004174797 RP004176714 RP004187431 RP004188766 RP004201452 RP004210557 RP004212649 RP004217668 RP004218625 RP004226765 RP004226956 RP004229485 RP004242715 RP004267221 RP004275726 RP004304347 RP004304365 RP004310379 RP004338428 RP004356265 RP004371135 RP004371566 RP004381056 RP004410978 RP004414469 RP004422925 RP004431299 RP004460098 RP004473533 RP004478010
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010225 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46008
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gel CG1106 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Like vertebrates, Gel exists in two forms, one secreted the other cytoplasmic. Gene products and expression pattern are characterised. (Stella et al., 1994) Cloning and characterisation of a secretory form of Gel. (Heintzelman et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080126 NM_164319 NM_164321 NM_176394 NM_206426 NM_206427 NM_001043192 RefSeq (Proteins) • NP_524865 NP_730788 NP_730790 NP_788571 NP_996148 NP_996149 NP_001036657 DDBJ / EMBL / GenBank • AAA28568 AAF52162 AAF52163 AAF52164 AAM50316 AAN13333 AAO41509 AAO41510 ABI31119 AF187729 AI534589 AW944505 AY119662 CAA53294 CAA53295 L08794 X75629 X75630 Entrez Gene - A searchable database of RefSeq genes. • 46008 UniProtKB/Swiss-Prot • Q07171
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Villin/Gelsolin (IPR007122) Gelsolin domain (IPR007123) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00144
Linkouts
	BioGRID - A database of protein and genetic interactions • 70060 DroID - A comprehensive database of gene and protein interactions. • FBgn0010225 DRSC - Results from RNAi screens. • FBgn0010225 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010225 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1106-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010225 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46008 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46008 modMine - Data generated by the modENCODE project. • FBgn0010225
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG1106 (Karlsson et al., 2004, Goldstein and Gunawardena, 2000, Rogers et al., 2003, Ni et al., 2008, Cammarato et al., 2011, Ni et al., 2010.12.1) DGS (Heintzelman et al., 1993) gel (Stella, 1993.11.3, Stella, 1993.11.3, Irion, 1999.9.16) Gel (Stroschein-Stevenson et al., 2006, Bakal et al., 2007, Andreyeva et al., 2007, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Drosophila Gelsolin (Heintzelman et al., 1993) gelsolin (Petit et al., 2002, Heintzelman, 1993.5.6, Chanut-Delalande et al., 2006, Borghese et al., 2006, Singh et al., 2010, Duboff et al., 2012) Gelsolin (Rogers et al., 2003, Hoopfer et al., 2008, Bakal et al., 2007, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBan0001106 FBgn0037221
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 9 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Duboff et al., 2012, Neuron 75(4): 618--632 Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...