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Gene Dmel\GstS1

General Information
Symbol	Dmel\GstS1	Species	D. melanogaster
Name	Glutathione S transferase S1	Annotation symbol	CG8938
Feature type	protein_coding_gene	FlyBase ID	FBgn0010226
Gene Model Status	Current	Stock availability	33 publicly available
Also Known As	Gst2, GST-2, DmGSTS1-1, DmGST2, DmGST-2, GST S1, DmGSTS1, GST, l(2)k08805
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	53F7-53F8	Sequence location	2R:12,980,758..12,984,935 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Glutathione S transferase S1 is referred to in FlyBase by the symbol Dmel\GstS1 (CG8938, FBgn0010226). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glutathione peroxidase activity; glutathione transferase activity. It is reported to be involved in the biological process: response to oxidative stress. 53 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Glutathione S-transferase, C-terminal; Glutathione S-transferase, C-terminal-like; Glutathione S-transferase, N-terminal; Glutathione S-transferase/chloride channel, C-terminal; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderately high expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult midgut, larval hindgut, adult heart, larval fat body, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1623957_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of GstS1. Gene sequence location is 2R:12980758..12984935.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27859 HFA07436 Unknown western blot Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood adult stage day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood indirect flight muscle day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 53F7-53F8   Limits computationally determined from genome sequence between P{lacW}l(2)k11405k11405&P{EP}EP641 and P{lacW}l(2)k10815k10815
Experimentally Determined Cytological Location
Cytogenetic map Notes References 53F-53F     (Beall, 1993.1.20) 53F1-53F5   (determined by in situ hybridisation)   (Spradling et al., 1999) 53F4-53F5   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 53F-53F   (determined by in situ hybridisation)   (Beall et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\GstS1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) GstS1-RA FBtr0087006  NM_166216   1757   249 GstS1-RB FBtr0087005  NM_079043   1786   249 GstS1-RC FBtr0100258  NM_166217   1419   249
Additional Transcript Data & Comments
Reported size (kB)	1.9, 1.6 (northern blot) (Beall et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein GstS1-PA   FBpp0086157   27.6   249   4.29     NP_725653   AAF57901 GstS1-PB   FBpp0086156   27.6   249   4.29     NP_523767   AAF57900 GstS1-PC   FBpp0099646   27.6   249   4.29     NP_725654   AAM68496
Additional Polypeptide Data & Comments
Reported size (kDa)	247 (aa) (Beall et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutathione S-transferase, N-terminal (IPR004045) Glutathione S-transferase, C-terminal (IPR004046) Glutathione S-transferase, C-terminal-like (IPR010987) Thioredoxin-like fold (IPR012336) Glutathione S-transferase/chloride channel, C-terminal (IPR017933) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1M0U
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202360   AA246200   AA246244   AA246694   AA392169   AA439718   AA567208   AA735338   AA942452   AA949666   AA951750   AE013599 AAF57900   AE013599 AAF57901   AE013599 AAM68496   AI257420   AI296789   AI386582   AI455098   AI511685   AI514192   AI514193   AI516767   AI518506   AI944849   AI945311   AI946067   AI946526   AI946586   AQ024976   AQ025024   AQ025624   AQ025648   AQ025868   AQ025892   AQ025976   AQ026453   AQ073410   AY118328 AAM48357   BE975096   BE975194   BE975406   BE975407   BE976720   BE976863   BE978379   BE978944   BF486191   BF486544   BF488123   BF488555   BF489717   BF490005   BF490380   BF491420   BF494054   BF495362   BF497862   BF500115   BF500278   BF502129   BF503688   BF504238   BF504455   BG631925   BG635312   BI163466   BI163530   BI164518   BI167017   BI168145   BI169332   BI170324   BI173900   BI214260   BI215475   BI216905   BI228079   BI229340   BI229751   BI231260   BI233192   BI237169   BI238142   BI240505   BI240969   BI352249   BI356330   BI363373   BI364486   BI364955   BI481555   BI483979   BI484656   BI486720   BI573897   BI573898   BI578682   BI580412   BI605672   BI611530   BI613411   BI623826   BI629876   BI634180   CA804640   CK660512   CL705933   CO181857   CO182497   CO184276   CO184480   CO185908   CO187809   CO193207   CO266122   CO272709   CO276211   CO282866   CO283873   CO283908   CO296322   CO305353   CO323992   CO336054   CO341447   CZ468887   CZ469187   CZ474140   CZ475852   CZ475853   CZ486897   EC055827   EC059493   EC071883   EC083301   EC090504   EC195183   EC200617   EC201855   EC232923   EC240620   EC247597   EC252186   EC267755   ES688730   ES689486   ES691189   ES691201   ES691213   ES691214   ES691246   ES691249   ES691265   ES691330   ES691350   ES691376   ES691541   ES691551   ES691584   ES691604   ES691682   ES691702   ES691707   ES691756   ES691759   ES691798   ES691812   ES691828   ES691848   ES691849   ES691852   ES691874   ES691892   ES691911   ES694480   ES695215   ES696591   EV580141   GH941387   GH941989   GH942091   GH943683   GH947647   GH950884   GH953299   GH956266   GH959222   GH961709   GH968742   GH969472   GH975924   GH976340   GH977281   GH977504   GH977510   GH978044   GH981879   GH983582   GH984159   M95198 AAA28596
UniProtKB/Swiss-Prot	P41043
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Beall et al., 1992)
Additional Descriptive Data
	GstS1 transcripts are detected throughout development on northern blots. (Beall et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   indirect flight muscle   (Clayton et al., 1998)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010226    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010226 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderately high expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010226 expression level Developmental Stage   Expression Level embryo 00-02hr    9872 embryo 02-04hr    13453 embryo 04-06hr    6695 embryo 06-08hr    2119 embryo 08-10hr    2838 embryo 10-12hr    3162 embryo 12-14hr    3621 embryo 14-16hr    8676 embryo 16-18hr    9504 embryo 18-20hr    7190 embryo 20-22hr    7144 embryo 22-24hr    6431 larva L1    6063 larva L2    7346 larva L3 12hr old    8712 larva L3 puffstage 1-2    8688 larva L3 puffstage 3-6    9885 larva L3 puffstage 7-9    9201 white prepupae new    9866 white prepupae 12hr    17589 white prepupae 24hr    20011 pupae 2d postWPP    19520 pupae 3d postWPP    133583 pupae 4d postWPP    179917 adult male 01day    71976 adult male 05day    23648 adult male 30day    17647 adult female 01day    63490 adult female 05day    6163 adult female 30day    5424 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9872) embryo 02-04hr  (13453) embryo 04-06hr  (6695) embryo 06-08hr  (2119) embryo 08-10hr  (2838) embryo 10-12hr  (3162) embryo 12-14hr  (3621) embryo 14-16hr  (8676) embryo 16-18hr  (9504) embryo 18-20hr  (7190) embryo 20-22hr  (7144) embryo 22-24hr  (6431) larva L1  (6063) larva L2  (7346) larva L3 12hr old  (8712) larva L3 puffstage 1-2  (8688) larva L3 puffstage 3-6  (9885) larva L3 puffstage 7-9  (9201) white prepupae new  (9866) white prepupae 12hr  (17589) white prepupae 24hr  (20011) pupae 2d postWPP  (19520) pupae 3d postWPP  (133583) pupae 4d postWPP  (179917) adult male 01day  (71976) adult male 05day  (23648) adult male 30day  (17647) adult female 01day  (63490) adult female 05day  (6163) adult female 30day  (5424) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9872) embryo 02-04hr  (13453) embryo 04-06hr  (6695) embryo 06-08hr  (2119) embryo 08-10hr  (2838) embryo 10-12hr  (3162) embryo 12-14hr  (3621) embryo 14-16hr  (8676) embryo 16-18hr  (9504) embryo 18-20hr  (7190) embryo 20-22hr  (7144) embryo 22-24hr  (6431) larva L1  (6063) larva L2  (7346) larva L3 12hr old  (8712) larva L3 puffstage 1-2  (8688) larva L3 puffstage 3-6  (9885) larva L3 puffstage 7-9  (9201) white prepupae new  (9866) white prepupae 12hr  (17589) white prepupae 24hr  (20011) pupae 2d postWPP  (19520) pupae 3d postWPP  (133583) pupae 4d postWPP  (179917) adult male 01day  (71976) adult male 05day  (23648) adult male 30day  (17647) adult female 01day  (63490) adult female 05day  (6163) adult female 30day  (5424) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9872 embryo 02-04hr  (13453) embryo 04-06hr    6695 embryo 06-08hr    2119 embryo 08-10hr    2838 embryo 10-12hr    3162 embryo 12-14hr    3621 embryo 14-16hr    8676 embryo 16-18hr    9504 embryo 18-20hr    7190 embryo 20-22hr    7144 embryo 22-24hr    6431 larva L1    6063 larva L2    7346 larva L3 12hr old    8712 larva L3 puffstage 1-2    8688 larva L3 puffstage 3-6    9885 larva L3 puffstage 7-9    9201 white prepupae new    9866 white prepupae 12hr  (17589) white prepupae 24hr  (20011) pupae 2d postWPP  (19520) pupae 3d postWPP  (133583) pupae 4d postWPP  (179917) adult male 01day  (71976) adult male 05day  (23648) adult male 30day  (17647) adult female 01day  (63490) adult female 05day    6163 adult female 30day    5424 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9872 embryo 02-04hr    13453 embryo 04-06hr    6695 embryo 06-08hr    2119 embryo 08-10hr    2838 embryo 10-12hr    3162 embryo 12-14hr    3621 embryo 14-16hr    8676 embryo 16-18hr    9504 embryo 18-20hr    7190 embryo 20-22hr    7144 embryo 22-24hr    6431 larva L1    6063 larva L2    7346 larva L3 12hr old    8712 larva L3 puffstage 1-2    8688 larva L3 puffstage 3-6    9885 larva L3 puffstage 7-9    9201 white prepupae new    9866 white prepupae 12hr    17589 white prepupae 24hr    20011 pupae 2d postWPP    19520 pupae 3d postWPP    133583 pupae 4d postWPP    179917 adult male 01day    71976 adult male 05day    23648 adult male 30day    17647 adult female 01day    63490 adult female 05day    6163 adult female 30day    5424 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010226 expression level Developmental Stage   Expression Level embryo 00-02hr    9872 embryo 02-04hr    13453 embryo 04-06hr    6695 embryo 06-08hr    2119 embryo 08-10hr    2838 embryo 10-12hr    3162 embryo 12-14hr    3621 embryo 14-16hr    8676 embryo 16-18hr    9504 embryo 18-20hr    7190 embryo 20-22hr    7144 embryo 22-24hr    6431 larva L1    6063 larva L2    7346 larva L3 12hr old    8712 larva L3 puffstage 1-2    8688 larva L3 puffstage 3-6    9885 larva L3 puffstage 7-9    9201 white prepupae new    9866 white prepupae 12hr    17589 white prepupae 24hr    20011 pupae 2d postWPP    19520 pupae 3d postWPP    133583 pupae 4d postWPP    179917 adult male 01day    71976 adult male 05day    23648 adult male 30day    17647 adult female 01day    63490 adult female 05day    6163 adult female 30day    5424 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9872) embryo 02-04hr  (13453) embryo 04-06hr  (6695) embryo 06-08hr  (2119) embryo 08-10hr  (2838) embryo 10-12hr  (3162) embryo 12-14hr  (3621) embryo 14-16hr  (8676) embryo 16-18hr  (9504) embryo 18-20hr  (7190) embryo 20-22hr  (7144) embryo 22-24hr  (6431) larva L1  (6063) larva L2  (7346) larva L3 12hr old  (8712) larva L3 puffstage 1-2  (8688) larva L3 puffstage 3-6  (9885) larva L3 puffstage 7-9  (9201) white prepupae new  (9866) white prepupae 12hr  (17589) white prepupae 24hr  (20011) pupae 2d postWPP  (19520) pupae 3d postWPP  (133583) pupae 4d postWPP  (179917) adult male 01day  (71976) adult male 05day  (23648) adult male 30day  (17647) adult female 01day  (63490) adult female 05day  (6163) adult female 30day  (5424) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9872) embryo 02-04hr  (13453) embryo 04-06hr  (6695) embryo 06-08hr  2119 embryo 08-10hr  (2838) embryo 10-12hr  (3162) embryo 12-14hr  (3621) embryo 14-16hr  (8676) embryo 16-18hr  (9504) embryo 18-20hr  (7190) embryo 20-22hr  (7144) embryo 22-24hr  (6431) larva L1  (6063) larva L2  (7346) larva L3 12hr old  (8712) larva L3 puffstage 1-2  (8688) larva L3 puffstage 3-6  (9885) larva L3 puffstage 7-9  (9201) white prepupae new  (9866) white prepupae 12hr  (17589) white prepupae 24hr  (20011) pupae 2d postWPP  (19520) pupae 3d postWPP  (133583) pupae 4d postWPP  (179917) adult male 01day  (71976) adult male 05day  (23648) adult male 30day  (17647) adult female 01day  (63490) adult female 05day  (6163) adult female 30day  (5424) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9872 embryo 02-04hr  13453 embryo 04-06hr    6695 embryo 06-08hr    2119 embryo 08-10hr    2838 embryo 10-12hr    3162 embryo 12-14hr    3621 embryo 14-16hr    8676 embryo 16-18hr    9504 embryo 18-20hr    7190 embryo 20-22hr    7144 embryo 22-24hr    6431 larva L1    6063 larva L2    7346 larva L3 12hr old    8712 larva L3 puffstage 1-2    8688 larva L3 puffstage 3-6    9885 larva L3 puffstage 7-9    9201 white prepupae new    9866 white prepupae 12hr  17589 white prepupae 24hr  20011 pupae 2d postWPP  19520 pupae 3d postWPP  (133583) pupae 4d postWPP  (179917) adult male 01day  (71976) adult male 05day  (23648) adult male 30day  17647 adult female 01day  (63490) adult female 05day    6163 adult female 30day    5424 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9872 embryo 02-04hr    13453 embryo 04-06hr    6695 embryo 06-08hr    2119 embryo 08-10hr    2838 embryo 10-12hr    3162 embryo 12-14hr    3621 embryo 14-16hr    8676 embryo 16-18hr    9504 embryo 18-20hr    7190 embryo 20-22hr    7144 embryo 22-24hr    6431 larva L1    6063 larva L2    7346 larva L3 12hr old    8712 larva L3 puffstage 1-2    8688 larva L3 puffstage 3-6    9885 larva L3 puffstage 7-9    9201 white prepupae new    9866 white prepupae 12hr    17589 white prepupae 24hr    20011 pupae 2d postWPP    19520 pupae 3d postWPP    133583 pupae 4d postWPP    179917 adult male 01day    71976 adult male 05day    23648 adult male 30day    17647 adult female 01day    63490 adult female 05day    6163 adult female 30day    5424 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010226    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010226 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult midgut, larval hindgut, adult heart, larval fat body, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010226 expression level Tissue   Expression Level Larval Central Nervous System    1048.25 Larval Midgut    948.8 Larval Hindgut    636.9 Larval Malpighian Tubules    101.5 Larval Fat Body    2974.7 Larval Salivary Gland    138.8 Larval Trachea    627.95 Larval Carcass    619.475 Adult Head    472.7 Adult Eye    646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut    651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart    762.375 Adult VirginFemale Spermatheca    1000.9 Adult InseminatedFemale Spermatheca    714.2 Adult Ovary    237.4 Adult Testis    2393.8 Adult Male Accessory Gland    294.4 Adult Carcass    769.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1048.25) Larval Midgut  (948.8) Larval Hindgut  (636.9) Larval Malpighian Tubules    101.5 Larval Fat Body  (2974.7) Larval Salivary Gland    138.8 Larval Trachea  (627.95) Larval Carcass  (619.475) Adult Head    472.7 Adult Eye  (646.125) Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut  (651.4) Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart  (762.375) Adult VirginFemale Spermatheca  (1000.9) Adult InseminatedFemale Spermatheca  (714.2) Adult Ovary    237.4 Adult Testis  (2393.8) Adult Male Accessory Gland    294.4 Adult Carcass  (769.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1048.25 Larval Midgut    948.8 Larval Hindgut    636.9 Larval Malpighian Tubules    101.5 Larval Fat Body  (2974.7) Larval Salivary Gland    138.8 Larval Trachea    627.95 Larval Carcass    619.475 Adult Head    472.7 Adult Eye    646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut    651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart    762.375 Adult VirginFemale Spermatheca  1000.9 Adult InseminatedFemale Spermatheca    714.2 Adult Ovary    237.4 Adult Testis  (2393.8) Adult Male Accessory Gland    294.4 Adult Carcass    769.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1048.25 Larval Midgut    948.8 Larval Hindgut    636.9 Larval Malpighian Tubules    101.5 Larval Fat Body    2974.7 Larval Salivary Gland    138.8 Larval Trachea    627.95 Larval Carcass    619.475 Adult Head    472.7 Adult Eye    646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut    651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart    762.375 Adult VirginFemale Spermatheca    1000.9 Adult InseminatedFemale Spermatheca    714.2 Adult Ovary    237.4 Adult Testis    2393.8 Adult Male Accessory Gland    294.4 Adult Carcass    769.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010226 expression level Tissue   Expression Level Larval Central Nervous System    1048.25 Larval Midgut    948.8 Larval Hindgut    636.9 Larval Malpighian Tubules    101.5 Larval Fat Body    2974.7 Larval Salivary Gland    138.8 Larval Trachea    627.95 Larval Carcass    619.475 Adult Head    472.7 Adult Eye    646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut    651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart    762.375 Adult VirginFemale Spermatheca    1000.9 Adult InseminatedFemale Spermatheca    714.2 Adult Ovary    237.4 Adult Testis    2393.8 Adult Male Accessory Gland    294.4 Adult Carcass    769.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1048.25) Larval Midgut  (948.8) Larval Hindgut  636.9 Larval Malpighian Tubules    101.5 Larval Fat Body  (2974.7) Larval Salivary Gland    138.8 Larval Trachea  627.95 Larval Carcass  619.475 Adult Head    472.7 Adult Eye  646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut  651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart  762.375 Adult VirginFemale Spermatheca  (1000.9) Adult InseminatedFemale Spermatheca  714.2 Adult Ovary    237.4 Adult Testis  (2393.8) Adult Male Accessory Gland    294.4 Adult Carcass  769.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1048.25 Larval Midgut    948.8 Larval Hindgut    636.9 Larval Malpighian Tubules    101.5 Larval Fat Body  (2974.7) Larval Salivary Gland    138.8 Larval Trachea    627.95 Larval Carcass    619.475 Adult Head    472.7 Adult Eye    646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut    651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart    762.375 Adult VirginFemale Spermatheca  1000.9 Adult InseminatedFemale Spermatheca    714.2 Adult Ovary    237.4 Adult Testis  (2393.8) Adult Male Accessory Gland    294.4 Adult Carcass    769.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1048.25 Larval Midgut    948.8 Larval Hindgut    636.9 Larval Malpighian Tubules    101.5 Larval Fat Body    2974.7 Larval Salivary Gland    138.8 Larval Trachea    627.95 Larval Carcass    619.475 Adult Head    472.7 Adult Eye    646.125 Adult Brain    288.3 Adult Thoracic-Abdominal Ganglion    398.8 Adult Crop    363.3 Adult Midgut    651.4 Adult Hindgut    220.3 Adult Malpighian Tubules    52.4 Adult Fat Body    390.1 Adult Salivary Gland    52.5 Adult Heart    762.375 Adult VirginFemale Spermatheca    1000.9 Adult InseminatedFemale Spermatheca    714.2 Adult Ovary    237.4 Adult Testis    2393.8 Adult Male Accessory Gland    294.4 Adult Carcass    769.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    472.7   NA  Eye    646.125   NA  Brain    288.3   1048.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    398.8   NA  Crop    363.3   948.8  Midgut    651.4   636.9  Hindgut    220.3   101.5  Malpighian Tubules    52.4   2974.7  Fat Body    390.1   138.8  Salivary Gland    52.5   NA  Heart    762.375   627.95  Trachea    NA   NA  VirginFemale Spermatheca    1000.9   NA  InseminatedFemale Spermatheca    714.2   NA  Ovary    237.4   NA  Testis    2393.8   NA  Male Accessory Gland    294.4   619.475  Carcass    769.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010226 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8938-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for GstS1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4c355 GstS1GS2160 lethal | recessive GstS104227 GstS1k08805 semi-viable | recessive GstS1GS2160 viable GstS1CB05261 GstS1EY07338 GstS1M26 Sterility Allele fertile GstS1EY07338 male sterile | recessive GstS1GS2160 Other Phenotypes Allele visible, with Scer\GAL429BD GstS1GS2160 visible, with Scer\GAL4hs.2sev GstS1GS2160 wild-type, with Scer\GAL4dpp.blk1 GstS1GS2160 Phenotype manifest in Allele eye, with Scer\GAL4hs.2sev GstS1GS2160 macrochaeta GstS1BG01263 wing, with Scer\GAL429BD GstS1GS2160
Classical Alleles ( 50 )
For All Classical Alleles Show
Allele of GstS1 Class Mutagen Stocks Known lesion GstS1k08805 P-element activity 2 Yes GstS1k09303 P-element activity 2 Yes GstS102 1 -- GstS104227 P-element activity 1 -- GstS106253 P-element activity 1 -- GstS15-HA-1111 1 -- GstS15-HA-1118 1 -- GstS15-HA-1144 1 -- GstS15-HA-1218 1 -- GstS15-HA-1237 1 -- GstS15-HA-1337 1 -- GstS15-HA-1488 1 -- GstS15-HA-2769 1 -- GstS15-SZ-3374 1 -- GstS15-SZ-3399 1 -- GstS15-SZ-3402 1 -- GstS15-SZ-3413 1 -- GstS15-SZ-3423 1 -- GstS15-SZ-3597 1 -- GstS15-SZ-3969 1 -- GstS15-SZ-3993 1 -- GstS1c03905 piggyBac transposase 1 -- GstS1CB-0757-3 1 -- GstS1CB-5143-3 1 -- GstS1CB-5665-3 1 -- GstS1DG19302 1 -- GstS1EY07338 P-element activity 1 -- GstS1f04362 piggyBac transposase 1 -- GstS1UM-8262-3 1 -- GstS15-HA-1635 0 -- GstS15-HA-2185 0 -- GstS15-HA-2439 0 -- GstS15-SZ-3439 0 -- GstS1BG01263 P-element activity 0 Yes GstS1c02301 0 -- GstS1c04336 piggyBac transposase 0 -- GstS1CB05261 P-element activity 0 Yes GstS1d04795 P-element activity 0 -- GstS1d05815 0 -- GstS1d07643 P-element activity 0 -- GstS1EP1074 P-element activity 0 -- GstS1EP1227 P-element activity 0 Yes GstS1EP2222 P-element activity 0 -- GstS1EP2223 P-element activity 0 Yes GstS1EP337 P-element activity 0 -- GstS1EP615 P-element activity 0 -- GstS1EP845 P-element activity 0 -- GstS1GS2160 Delta2-3 0 Yes GstS1M26 loss of function allele P-element activity 0 Yes GstS1NP1534 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of GstS1 Class Mutagen Stocks Known lesion GstS1GD16335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GstS1HM05063 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GstS1Scer\UAS.P\T.cWa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)ED1 (Whitworth et al., 2005) Df(2R)Exel6065 (Ryder, 2004.4.26) Df(2R)P803-Δ15 (Tomkiel, 2001.12.6)
Not disrupted in	Df(2R)ED1 (Ryder and Roote, 2004.11.10)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16335} NA P{TRiP.HM05063} NA P{UASP-GstS1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP543 NA P{EP}EP641 NA P{EP}EP670 NA P{EP}EP828 NA P{EP}EP1236EP1236 NA P{EP}EP2012EP2012 NA P{EP}EP2022 NA P{EP}EP2031EP2031 NA P{EP}EP2064 NA P{EP}EP2262 NA P{EP}EP2307 NA P{EP}GstS1EP337 NA P{EP}GstS1EP615 NA P{EP}GstS1EP845 NA P{EP}GstS1EP1074 NA P{EP}GstS1EP1227 NA P{EP}GstS1EP2222 NA P{EP}GstS1EP2223 NA P{EPgy2}GstS1EY07338 NA P{GSV1}C459C459 NA P{GSV1}GstS1GS2160 NA P{XP}GstS1d04795 NA P{XP}GstS1d05815 NA P{XP}GstS1d07643 NA insertion of enhancer trap P{lacW}GstS1k08805 No P{lacW}GstS1k09303 No P{lacW}l(2)SH1529SH1529 No P{PZ}GstS104227 No P{PZ}GstS106253 No miscellaneous insertions P{attP.w+.attP}JB53F NA P{GT1}GstS1BG01263 NA P{PTT-GB}GstS1CB05261 NA P{RS3}GstS1CB-0757-3 NA P{RS3}GstS1CB-5143-3 NA P{RS3}GstS1CB-5665-3 NA P{RS3}GstS1UM-8262-3 NA P{RS5}GstS15-HA-1111 NA P{RS5}GstS15-HA-1118 NA P{RS5}GstS15-HA-1144 NA P{RS5}GstS15-HA-1218 NA P{RS5}GstS15-HA-1237 NA P{RS5}GstS15-HA-1337 NA P{RS5}GstS15-HA-1488 NA P{RS5}GstS15-HA-1635 NA P{RS5}GstS15-HA-2185 NA P{RS5}GstS15-HA-2439 NA P{RS5}GstS15-HA-2769 NA P{RS5}GstS15-SZ-3374 NA P{RS5}GstS15-SZ-3399 NA P{RS5}GstS15-SZ-3402 NA P{RS5}GstS15-SZ-3413 NA P{RS5}GstS15-SZ-3423 NA P{RS5}GstS15-SZ-3439 NA P{RS5}GstS15-SZ-3597 NA P{RS5}GstS15-SZ-3969 NA P{RS5}GstS15-SZ-3993 NA P{UASp-YFP.Rab21.Q73L}GstS102 NA P{wHy}GstS1DG19302 NA PBac{PB}GstS1c02301 NA PBac{PB}GstS1c03905 NA PBac{PB}GstS1c04336 NA PBac{WH}GstS1f04362 NA insertion of enhancer trap binary system P{GawB}GstS1NP1534 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
glutathione peroxidase activity inferred from direct assay (Singh et al., 2001) glutathione transferase activity inferred from direct assay (Singh et al., 2001)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
glutathione transferase activity inferred from sequence or structural similarity with UniProtKB:P46437 (FlyBase, 1992-) non-traceable author statement (Beall, 1993.1.20, Swiss-Prot Project Members, 1995.2.1) non-traceable author statement (assigned by UniProtKB) (Beall et al., 1992)
Biological Process
CV term Evidence References
response to oxidative stress non-traceable author statement (Driscoll and Gerstbrein, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions GstS1 allele Gene References GstS104227 Kr (Abrell et al., 2000) GstS1EP845 pnr (Pena-Rangel et al., 2002) unspecified park (Whitworth et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62625 DroID - A comprehensive database of gene and protein interactions. • FBgn0010226 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36927
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13422 Dere\GG22217 Dgri\GH20881 Dmoj\GI21003 Dper\GL17264 Dpse\GA21422 Dsec\GM20005 Dsim\GD25495 Dvir\GJ20716 Dwil\GK17930 Dyak\GE14214
Curated drosophilid orthologs	Dpse\GA21422   Dsim\Gst2 (Le Goff et al., 2001) Dsim\GstS1 (Le Goff et al., 2003)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011741-PA Aedes aegypti (mosquito) AGAP010404-PA Anopheles gambiae (mosquito) XP_394518.1 Apis mellifera (honey bee) XP_001946539.1 Acyrthosiphon pisum (pea aphid) 6133 Batrachochytrium dendrobatidis (chytrid fungus) 90240 Branchiostoma floridae (lancelet) BGIBMGA009107-PA Bombyx mori (silk worm) ENSBTAP00000022700 Bos taurus (bovine) CN08085 Caenorhabditis brenneri (small nematode) CN18706 Caenorhabditis brenneri (small nematode) CBP09588 Caenorhabditis briggsae (nematode) CE04834 Caenorhabditis elegans (worm) ENSCAFP00000035318 Canis familiaris (dog) ENSCINP00000025179 Ciona intestinalis (sea squirt) JA01817 Caenorhabditis japonica (nematode) CPIJ006160 Culex pipens (mosquito) ENSCPOP00000019270 Cavia porcellus (guinea pig) 164603 Chlamidomonas reinhardtii (green alga) RP14750 Caenorhabditis remanei (nematode) ENSCSAVP00000018547 Ciona savignyi (sedentary tunicate) 21967 Capitella spl (polychaete worm) DDB0231432 Dictyostelium discoideum (amoeba) DDB0238181 Dictyostelium discoideum (amoeba) 230761 Daphnia pulex (daphnia) ENSDARP00000004830 Danio rerio (zebra fish) ENSECAP00000004212 Equus caballus (horse) ENSGACP00000010161 Gymnopilus aculeatus (mushroom) ENSGACP00000010188 Gymnopilus aculeatus (mushroom) ENSGALP00000016919 Gallus gallus (chicken) 77319 Hypsipyla robusta (cedar shoot borer) ENSP00000295256 Homo sapiens (human) ISCW022157-PA Ixodes scapularis (deer tick) 160331 Lottia gigantea (owl limpet) 6508 Monocosta brevicollis (choanoflagellate) ENSMODP00000024048 Monodelphis domestica (gray opossum) ENSMMUP00000029279 Macaca mulatta (rhesus monkey) ENSMUSP00000031982 Mus musculus (house mouse) 236609 Nematostella vectensis (starlet anemone) XP_001599411.1 Nasonia vitripennis (wasp) ENSOANP00000021708 Ornithorynchus anatinus (platypus) ENSORLP00000007503 Oryzias latipes (japanese killifish) 30299 Ostreococcus tauri (green alga) PF14_0187 Plasmodium falciparum (protozoal parasite) PHUM001378-PA Pediculus humanus (human body louse) PP04106 Pristionchus pacificus (nematode) ENSPPYP00000016678 Pongo pygmaeus (orangutan) 145196 Phytophthora sojae (root rot pathogen) ENSPTRP00000027981 Pan troglodytes (chimpanzee) PVX_085515 Plasmodium vivax (protozoal parasite) ENSRNOP00000008826 Rattus norvegicus (norway rat) Smp_054160 Schistosoma mansoni (trematode parasite) XP_795664.1 Strongylocentrotus purpuratus (purple sea urchin) 34448 Trichoplax adhaerens (metazoa) 63110 Trichoplax adhaerens (metazoa) 63898 Trichoplax adhaerens (metazoa) XP_976145.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018200 Tetraodon nigroviridis (green spotted pufferfish) 264121 Thalassiosira pseudonana (marine diatom) ENSTRUP00000004010 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000041633 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19347 NV21194 NV15805 NV14977 NV14196 NV14185 LH14582 ISCW024608 ISCW022157 ISCW021288 ISCW021285 ISCW019306 ISCW019307 ISCW019308 ISCW017237 ISCW017235 ISCW013757 ISCW009570 ISCW008578 ISCW007756 ISCW005930 ISCW004524 ISCW004523 ISCW003771 FBgn0231834 FBgn0219929 FBgn0207854 FBgn0196786 FBgn0174890 JGI_V11_234554 JGI_V11_230303 JGI_V11_305501 JGI_V11_307787 JGI_V11_230650 JGI_V11_223594 JGI_V11_316498 JGI_V11_210571 JGI_V11_230761 JGI_V11_223730 JGI_V11_302333 JGI_V11_316534 JGI_V11_241024 JGI_V11_219884 FBgn0081409 FBgn0154867 FBgn0143735 FBgn0128343 FBgn0114390 FBgn0090454 CPIJ006159 CPIJ006160 BGIBMGA009107 BGIBMGA009106 ACYPI42285 ACYPI009519 ACYPI009326 ACYPI002679 ACYPI002127 ACYPI000794 GB30268 GB14372 GST_ANOGA GSTS1 PHUM284770 GLEAN_03496 GLEAN_03231 GLEAN_03232 GLEAN_03233 GLEAN_00067 GLEAN_13948
Stocks & Reagents
Stocks Listed in FlyBase ( 33 )
Bloomington	28885 y1 v1; P{TRiP.HM05063}attP2
Harvard	- PBac{PB}GstS1c03905 - PBac{WH}GstS1f04362
Kyoto	123316 w1118; P{RS3}GstS1CB-0757-3 123482 w1118; P{RS3}GstS1CB-5143-3 123742 w1118; P{RS3}GstS1CB-5665-3 124452 w1118; P{RS3}GstS1UM-8262-3 125078 w1118; P{RS5}GstS15-HA-1111 125085 w1118; P{RS5}GstS15-HA-1118 125105 w1118; P{RS5}GstS15-HA-1144 125148 w1118; P{RS5}GstS15-HA-1218
VDRC	v50140 w1118; P{GD16335}v50140
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Genomic Clones ( 1 )
	BACR32P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 145 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21131
Other clones	DPiM_LD21131
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02463 AT04359 AT04863 AT05557 AT05819 AT12165 AT15020 AT15123 AT17765 AT20410 AT20871 AT23221 AT24020 AT25847 AT26267 AT26718 AT26845 AT28158 AT31856 GH16713 GH27266 GH27267 GM01329 GM18518 LD02510 LD05612 LD06036 LD06154 LD11065 LD14356 LD26681 LD29640 LD32452 LD38044 LD42819 LD43168 LP05778 LP10870 LP19140 RE02867 RE02952 RE04217 RE07285 RE08709 RE10472 RE11731 RE17034 RE20013 RE20706 RE21883 RE24189 RE25508 RE27105 RE27594 RE29481 RE33344 RE34531 RE37357 RE37938 RE42446 RE48162 RE49614 RE50162 RE64127 RE66974 RE67791 RE70179 RE72580 RE74605 RH17855 RH37605 RH42560 RH56176 RH58809 RH71525
Other clones	9141 9525 29992.2 63169 79980 82468 214407.72 273136 556942 bs06b08 bs11d01 bs20d11 bs27d09 bs28b04 bs38e10 bs39f08 bs43b02 bs55a07 bs56h10 bs78a06 bs84g03 CK01.13B.H8 CK01.40A.B8 CK01.89A.E11 Dmel_dig_017390_0668_2518 EC15112 EC22831 EC27692 EC28151 EC35286 EC055827 EK014264 EK033628 EK108115 EK120008 EK145006 EK161506 EK164711 EK164762 EK192212 EK213358 EK248303 EN11730 EP12450 ESG0114c.B21_D09 RC0-DA0001-120700-111-F02 RH09366 RP004008273 RP004082445 RP004132008 RP004167652 RP004201127 RP004206766 RP004208281 RP004226159 RP004249040 RP004259952 RP004260542 RP004264940 RP004268037 RP004288850 RP004289502 RP004296747 RP004322028 RP004331886 RP004440729 RP004450949 RP004533651
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010226 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36927
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gst2 l(2)04227 (Misra, 2000.8.9)
Additional comments	FlyBase curator comment: "EP2012" overexpression phenotype stated to be due to its effect on GstS1 but orientation of the P{EP} element suggests otherwise. FlyBase curator comment: "EP2031" overexpression phenotype stated to be due to its effect on GstS1 but orientation of the P{EP} element suggests otherwise. (Singh et al., 2005)
Other Comments
	Encoded product has very little activity for typical GST substrates, has significant activity in the GSH conjugation of the lipid peroxidation product 4-HNE, and is expressed in tissues (CNS and imaginal discs) not normally associated with detoxification. (Singh et al., 2001) Encoded product may have a protective role against the deleterious effects of oxidative stress. (Singh et al., 2001) GstS1 interacts with the TnH-34 isoform of troponin-H in asynchronous indirect flight muscle. (Clayton et al., 1998) A second gene that encodes glutathione S-transferase has been isolated. (Beall et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079043 NM_166216 NM_166217 RefSeq (Proteins) • NP_523767 NP_725653 NP_725654 DDBJ / EMBL / GenBank • AA439718 AA735338 AA942452 AAA28596 AAF57900 AAF57900.1 AAF57901 AAF57901.1 AAM48357 AAM68496 AI257420 AI455098 AI516767 AI518506 AI944849 AI945311 AI946067 AI946526 AI946586 AQ024976 AQ025024 AQ025624 AQ025648 AQ025868 AQ025892 AQ025976 AQ026453 AQ073410 AY118328 CL705933 CZ468887 CZ469187 CZ474140 CZ475852 CZ475853 CZ486897 M95198 Entrez Gene - A searchable database of RefSeq genes. • 36927 UniProtKB/Swiss-Prot • P41043
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glutathione S-transferase, N-terminal (IPR004045) Glutathione S-transferase, C-terminal (IPR004046) Glutathione S-transferase, C-terminal-like (IPR010987) Thioredoxin-like fold (IPR012336) Glutathione S-transferase/chloride channel, C-terminal (IPR017933) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1M0U
Linkouts
	BioGRID - A database of protein and genetic interactions • 62625 DroID - A comprehensive database of gene and protein interactions. • FBgn0010226 DRSC - Results from RNAi screens. • FBgn0010226 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010226 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8938-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010226 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36927 InParanoid A subset of ortholog calls from InParanoid. • AAEL011741-PA Aedes aegypti (mosquito) AGAP010404-PA Anopheles gambiae (mosquito) XP_394518.1 Apis mellifera (honey bee) XP_001946539.1 Acyrthosiphon pisum (pea aphid) 6133 Batrachochytrium dendrobatidis (chytrid fungus) 90240 Branchiostoma floridae (lancelet) BGIBMGA009107-PA Bombyx mori (silk worm) ENSBTAP00000022700 Bos taurus (bovine) CN08085 Caenorhabditis brenneri (small nematode) CN18706 Caenorhabditis brenneri (small nematode) CBP09588 Caenorhabditis briggsae (nematode) CE04834 Caenorhabditis elegans (worm) ENSCAFP00000035318 Canis familiaris (dog) ENSCINP00000025179 Ciona intestinalis (sea squirt) JA01817 Caenorhabditis japonica (nematode) CPIJ006160 Culex pipens (mosquito) ENSCPOP00000019270 Cavia porcellus (guinea pig) 164603 Chlamidomonas reinhardtii (green alga) RP14750 Caenorhabditis remanei (nematode) ENSCSAVP00000018547 Ciona savignyi (sedentary tunicate) 21967 Capitella spl (polychaete worm) DDB0231432 Dictyostelium discoideum (amoeba) DDB0238181 Dictyostelium discoideum (amoeba) 230761 Daphnia pulex (daphnia) ENSDARP00000004830 Danio rerio (zebra fish) ENSECAP00000004212 Equus caballus (horse) ENSGACP00000010161 Gymnopilus aculeatus (mushroom) ENSGACP00000010188 Gymnopilus aculeatus (mushroom) ENSGALP00000016919 Gallus gallus (chicken) 77319 Hypsipyla robusta (cedar shoot borer) ENSP00000295256 Homo sapiens (human) ISCW022157-PA Ixodes scapularis (deer tick) 160331 Lottia gigantea (owl limpet) 6508 Monocosta brevicollis (choanoflagellate) ENSMODP00000024048 Monodelphis domestica (gray opossum) ENSMMUP00000029279 Macaca mulatta (rhesus monkey) ENSMUSP00000031982 Mus musculus (house mouse) 236609 Nematostella vectensis (starlet anemone) XP_001599411.1 Nasonia vitripennis (wasp) ENSOANP00000021708 Ornithorynchus anatinus (platypus) ENSORLP00000007503 Oryzias latipes (japanese killifish) 30299 Ostreococcus tauri (green alga) PF14_0187 Plasmodium falciparum (protozoal parasite) PHUM001378-PA Pediculus humanus (human body louse) PP04106 Pristionchus pacificus (nematode) ENSPPYP00000016678 Pongo pygmaeus (orangutan) 145196 Phytophthora sojae (root rot pathogen) ENSPTRP00000027981 Pan troglodytes (chimpanzee) PVX_085515 Plasmodium vivax (protozoal parasite) ENSRNOP00000008826 Rattus norvegicus (norway rat) Smp_054160 Schistosoma mansoni (trematode parasite) XP_795664.1 Strongylocentrotus purpuratus (purple sea urchin) 34448 Trichoplax adhaerens (metazoa) 63110 Trichoplax adhaerens (metazoa) 63898 Trichoplax adhaerens (metazoa) XP_976145.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018200 Tetraodon nigroviridis (green spotted pufferfish) 264121 Thalassiosira pseudonana (marine diatom) ENSTRUP00000004010 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000041633 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36927 modMine - Data generated by the modENCODE project. • FBgn0010226 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19347 NV21194 NV15805 NV14977 NV14196 NV14185 LH14582 ISCW024608 ISCW022157 ISCW021288 ISCW021285 ISCW019306 ISCW019307 ISCW019308 ISCW017237 ISCW017235 ISCW013757 ISCW009570 ISCW008578 ISCW007756 ISCW005930 ISCW004524 ISCW004523 ISCW003771 FBgn0231834 FBgn0219929 FBgn0207854 FBgn0196786 FBgn0174890 JGI_V11_234554 JGI_V11_230303 JGI_V11_305501 JGI_V11_307787 JGI_V11_230650 JGI_V11_223594 JGI_V11_316498 JGI_V11_210571 JGI_V11_230761 JGI_V11_223730 JGI_V11_302333 JGI_V11_316534 JGI_V11_241024 JGI_V11_219884 FBgn0081409 FBgn0154867 FBgn0143735 FBgn0128343 FBgn0114390 FBgn0090454 CPIJ006159 CPIJ006160 BGIBMGA009107 BGIBMGA009106 ACYPI42285 ACYPI009519 ACYPI009326 ACYPI002679 ACYPI002127 ACYPI000794 GB30268 GB14372 GST_ANOGA GSTS1 PHUM284770 GLEAN_03496 GLEAN_03231 GLEAN_03232 GLEAN_03233 GLEAN_00067 GLEAN_13948
Synonyms & Secondary IDs ( 35 )
Reported As
Symbol Synonym	CG8938 (Norga et al., 2003, Quinones-Coello, 2007, Molnar et al., 2006, Perkins et al., 2009, Kim et al., 2010, Alias and Clark, 2007, Cammarato et al., 2011) DmGST2 (Aigaki et al., 2002, Toung et al., 1993, Morton, 1993, Morrissey et al., 1987) DmGST-2 (Ranson et al., 2001, Chelvanayagam et al., 2001, Beall et al., 1992) DmGst-2 (Ohba et al., 1998) DmGSTS1 (Chelvanayagam et al., 2001, Zimniak and Benes, 2002.7.15, Alias and Clark, 2007) DmGSTS1-1 (Sawicki et al., 2003, Agianian et al., 2003, Feng et al., 2003, Singh et al., 2002, Singh et al., 2001) DmGstS1-1 (Litvinova et al., 2008) Est2 (Spradling et al., 1999) GST (Pearson, 1996, Harshman et al., 1991, Rival et al., 2009) Gst2 (Apidianakis et al., 2005, Jasper et al., 2002, Fernandez-Funez et al., 2000, Toba et al., 1999, Altschul and Gish, 1996, Coronella and Cochrane, 1995, BDGP Project Members, 1994-1999, Apidianakis et al., 2007) GST-2 (Sawicki et al., 2003, Agianian et al., 2003, Singh et al., 2002, Clayton et al., 1998, Agianian et al., 2001, Vikhorev et al., 2010) GST2 (Zimniak and Benes, 2002.7.15, Le Goff et al., 2001, Coronella and Cochrane, 1995) gstD2 (Toung et al., 1993) GSTII (Lougarre et al., 1999) GSTS1 (Feng et al., 2003, Li et al., 2008, Alias and Clark, 2007) GST S1 (Feng et al., 2003, Rival et al., 2009, Alias and Clark, 2007) GstS1 (Trinh et al., 2008, Buszczak et al., 2007, Quinones-Coello, 2007, Zhang et al., 2007, Litvinova et al., 2008, Molnar et al., 2006, Ayroles et al., 2009, Takemori and Yamamoto, 2009, Tain et al., 2009, Greene et al., 2005, Branco et al., 2008, Baker et al., 2007, Dubruille et al., 2009, Kim et al., 2010, Seong et al., 2011) gsts1 (Ueda and Wu, 2008, Ueda and Wu, 2009) GstS1-1 (Litvinova et al., 2008) l(2)04227 (Abrell et al., 2000, ) l(2)k08805 (Pena-Rangel et al., 2002, Tomkiel, 2001.12.6, ) n(2)06253 (Spradling, 1999.12.9) S1 (Alias and Clark, 2007) unnamed (Vigoreaux, 2001)
Name Synonym	glutathione-S-transferase (Driscoll and Gerstbrein, 2003, Rival et al., 2009) Glutathione S-transferase (Zoghbi and Botas, 2002) Glutathione S-transferase 2 (Pearson, 1998) Glutathione S transferase 2   Glutathione-S-Transferase 2 (Apidianakis et al., 2007) glutathione S-transferase-2 (Clayton et al., 1998, Agianian et al., 2001, Vikhorev et al., 2010) glutathione-S-transferase (GST) S1 (Rival et al., 2009) Glutathione S transferase S1 (Zimniak and Benes, 2002.7.15, Cammarato et al., 2011) Glutathione S-transferase S1 (Litvinova et al., 2008, Greene et al., 2005) glutathione S-transferase-S1 (Ueda and Wu, 2009) glutathione transferase-related protein (Beall, 1993.1.20)
Secondary FlyBase IDs
	FBgn0010568 FBgn0022031
References ( 96 )
Generate a list of	All references relating to this gene ( 96 )
List References by type	Research paper  ( 50 ) Supplementary material  ( 6 ) Review  ( 5 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Kim et al., 2010, Exp. Gerontol. 45(7-8): 611--620 Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22. [FBrf0210880] Vikhorev et al., 2010, J. Muscle Res. Cell Motility 31(3): 171--179 In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation. [FBrf0211686] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...