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Gene Dmel\Klc

General Information
Symbol	Dmel\Klc	Species	D. melanogaster
Name	Kinesin light chain	Annotation symbol	CG5433
Feature type	protein_coding_gene	FlyBase ID	FBgn0010235
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	kinesin
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69E1-69E1	Sequence location	3L:12,739,716..12,743,156 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Kinesin light chain is referred to in FlyBase by the symbol Dmel\Klc (CG5433, FBgn0010235). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: microtubule motor activity. There is experimental evidence that it is involved in the biological process: microtubule-based movement. 15 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; embryonic/larval nervous system. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Kinesin light chain; Kinesin light chain repeat; Rabaptin, GTPase-Rab5 binding domain; Tetratricopeptide TPR-1; Tetratricopeptide TPR2; Tetratricopeptide repeat; Tetratricopeptide repeat-containing domain; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626731_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Klc. Gene sequence location is 3L:12739716..12743156.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms regulation of cell cycle
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69E1-69E1   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References 69D-69D     (Gauger, 1993) 69D-69D   (determined by in situ hybridisation)   (Gauger and Goldstein, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Klc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Klc-RA FBtr0075951  NM_079325   1843   508 Klc-RB FBtr0331555  NM_001274851   1841   508 Klc-RC FBtr0331556  NM_001274852   1876   507
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Klc-PA   FBpp0075683   58.0   508   6.18     NP_524049   AAF49890 Klc-PB   FBpp0303945   58.0   508   6.18     NP_001261780   AGB94473 Klc-PC   FBpp0303946   57.9   507   6.06     NP_001261781   AGB94474
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR2 (IPR013105) Kinesin light chain (IPR002151) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Rabaptin, GTPase-Rab5 binding domain (IPR015390) Kinesin light chain repeat (IPR015792) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49890   AE014296 AGB94473   AE014296 AGB94474   AY061164 AAL28712   CA806867   CO187061   CO196568   CO262336   CO278984   CO289831   CO290138   CO290375   CZ483495   EC057920   EC058850   EC059467   EC081691   EC081751   EC084192   EC194988   EC197144   EC205771   EC219922   EC226502   EC233474   EC238256   EC241931   EC243335   EC267475   EL869655   EL869657   EV579663   EV591965   GH748968   GH752446   GH754120   GH754774   GH755277   GH755295   GH759333   GH773518   GH774339   GH777461   GH783556   GH787201   GH791198   GH791938   GH797215   GH797814   GH803090   GH811303   GH815989   GH821760   GH822695   GH839816   GH865898   GH866302   GH867749   GH877849   GH883550   GH892336   GH901705   GH917299   GH919561   GH932884   GH937209   GH937422   L11013 AAA02481   L11328 AAA28669
UniProtKB/Swiss-Prot	P46824
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) labral sensory complex   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland    591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye    531.925 Adult Brain    671.9 Adult Thoracic-Abdominal Ganglion    746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (724.575) Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland  (591.3) Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye  531.925 Adult Brain  (671.9) Adult Thoracic-Abdominal Ganglion  (746.7) Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland    591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye    531.925 Adult Brain    671.9 Adult Thoracic-Abdominal Ganglion    746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland    591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye    531.925 Adult Brain    671.9 Adult Thoracic-Abdominal Ganglion    746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland    591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye    531.925 Adult Brain    671.9 Adult Thoracic-Abdominal Ganglion    746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland  591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye  531.925 Adult Brain  671.9 Adult Thoracic-Abdominal Ganglion  746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland    591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye    531.925 Adult Brain    671.9 Adult Thoracic-Abdominal Ganglion    746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    724.575 Larval Midgut    380.8 Larval Hindgut    411.2 Larval Malpighian Tubules    497.5 Larval Fat Body    405.2 Larval Salivary Gland    591.3 Larval Trachea    475.925 Larval Carcass    373.975 Adult Head    392.3 Adult Eye    531.925 Adult Brain    671.9 Adult Thoracic-Abdominal Ganglion    746.7 Adult Crop    339.8 Adult Midgut    286.9 Adult Hindgut    279.5 Adult Malpighian Tubules    320.8 Adult Fat Body    301.5 Adult Salivary Gland    371.5 Adult Heart    370.9 Adult VirginFemale Spermatheca    368.2 Adult InseminatedFemale Spermatheca    372.4 Adult Ovary    411.2 Adult Testis    175.8 Adult Male Accessory Gland    276 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    392.3   NA  Eye    531.925   NA  Brain    671.9   724.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    746.7   NA  Crop    339.8   380.8  Midgut    286.9   411.2  Hindgut    279.5   497.5  Malpighian Tubules    320.8   405.2  Fat Body    301.5   591.3  Salivary Gland    371.5   NA  Heart    370.9   475.925  Trachea    NA   NA  VirginFemale Spermatheca    368.2   NA  InseminatedFemale Spermatheca    372.4   NA  Ovary    411.2   NA  Testis    175.8   NA  Male Accessory Gland    276   373.975  Carcass    226.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    90 central nervous system, pupae P8    74 head, virgin 1-day female    31 head, virgin 4-day female    33 head, virgin 20-day female    29 head, mated 1-day female    30 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    43 head, mated 4-day male    44 head, mated 20-day male    55 salivary gland, larvae L3 wandering    39 salivary gland, white prepupae    112 digestive system, larvae L3 wandering    66 digestive system, 1-day adult    33 digestive system, 4-day adult    28 digestive system, 20-day adult    34 fat body, larvae L3 wandering    18 fat body, white prepupae    44 fat body, pupae P8    80 carcass, larvae L3 wandering    56 carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    27 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (90) central nervous system, pupae P8  (74) head, virgin 1-day female  (31) head, virgin 4-day female  (33) head, virgin 20-day female  (29) head, mated 1-day female  (30) head, mated 4-day female  (28) head, mated 20-day female  (28) head, mated 1-day male  (43) head, mated 4-day male  (44) head, mated 20-day male  (55) salivary gland, larvae L3 wandering  (39) salivary gland, white prepupae  (112) digestive system, larvae L3 wandering  (66) digestive system, 1-day adult  (33) digestive system, 4-day adult  (28) digestive system, 20-day adult  (34) fat body, larvae L3 wandering    18 fat body, white prepupae  (44) fat body, pupae P8  (80) carcass, larvae L3 wandering  (56) carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (54) testis, mated 4-day male  (27) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    90 central nervous system, pupae P8    74 head, virgin 1-day female    31 head, virgin 4-day female    33 head, virgin 20-day female    29 head, mated 1-day female    30 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    43 head, mated 4-day male    44 head, mated 20-day male    55 salivary gland, larvae L3 wandering    39 salivary gland, white prepupae  (112) digestive system, larvae L3 wandering    66 digestive system, 1-day adult    33 digestive system, 4-day adult    28 digestive system, 20-day adult    34 fat body, larvae L3 wandering    18 fat body, white prepupae    44 fat body, pupae P8    80 carcass, larvae L3 wandering    56 carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    27 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    90 central nervous system, pupae P8    74 head, virgin 1-day female    31 head, virgin 4-day female    33 head, virgin 20-day female    29 head, mated 1-day female    30 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    43 head, mated 4-day male    44 head, mated 20-day male    55 salivary gland, larvae L3 wandering    39 salivary gland, white prepupae    112 digestive system, larvae L3 wandering    66 digestive system, 1-day adult    33 digestive system, 4-day adult    28 digestive system, 20-day adult    34 fat body, larvae L3 wandering    18 fat body, white prepupae    44 fat body, pupae P8    80 carcass, larvae L3 wandering    56 carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    27 accessory gland, mated 4-day male    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    90 central nervous system, pupae P8    74 head, virgin 1-day female    31 head, virgin 4-day female    33 head, virgin 20-day female    29 head, mated 1-day female    30 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    43 head, mated 4-day male    44 head, mated 20-day male    55 salivary gland, larvae L3 wandering    39 salivary gland, white prepupae    112 digestive system, larvae L3 wandering    66 digestive system, 1-day adult    33 digestive system, 4-day adult    28 digestive system, 20-day adult    34 fat body, larvae L3 wandering    18 fat body, white prepupae    44 fat body, pupae P8    80 carcass, larvae L3 wandering    56 carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    27 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (90) central nervous system, pupae P8  (74) head, virgin 1-day female  31 head, virgin 4-day female  (33) head, virgin 20-day female  29 head, mated 1-day female  30 head, mated 4-day female  28 head, mated 20-day female  28 head, mated 1-day male  (43) head, mated 4-day male  (44) head, mated 20-day male  (55) salivary gland, larvae L3 wandering  (39) salivary gland, white prepupae  (112) digestive system, larvae L3 wandering  (66) digestive system, 1-day adult  (33) digestive system, 4-day adult  28 digestive system, 20-day adult  (34) fat body, larvae L3 wandering    18 fat body, white prepupae  (44) fat body, pupae P8  (80) carcass, larvae L3 wandering  (56) carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (54) testis, mated 4-day male  27 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    90 central nervous system, pupae P8    74 head, virgin 1-day female    31 head, virgin 4-day female    33 head, virgin 20-day female    29 head, mated 1-day female    30 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    43 head, mated 4-day male    44 head, mated 20-day male    55 salivary gland, larvae L3 wandering    39 salivary gland, white prepupae  112 digestive system, larvae L3 wandering    66 digestive system, 1-day adult    33 digestive system, 4-day adult    28 digestive system, 20-day adult    34 fat body, larvae L3 wandering    18 fat body, white prepupae    44 fat body, pupae P8    80 carcass, larvae L3 wandering    56 carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    27 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    90 central nervous system, pupae P8    74 head, virgin 1-day female    31 head, virgin 4-day female    33 head, virgin 20-day female    29 head, mated 1-day female    30 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    43 head, mated 4-day male    44 head, mated 20-day male    55 salivary gland, larvae L3 wandering    39 salivary gland, white prepupae    112 digestive system, larvae L3 wandering    66 digestive system, 1-day adult    33 digestive system, 4-day adult    28 digestive system, 20-day adult    34 fat body, larvae L3 wandering    18 fat body, white prepupae    44 fat body, pupae P8    80 carcass, larvae L3 wandering    56 carcass, 1-day adult    22 carcass, 4-day adult    22 carcass, 20-day adult    23 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    27 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr    34 embryo 10-12hr    59 embryo 12-14hr    63 embryo 14-16hr    63 embryo 16-18hr    57 embryo 18-20hr    53 embryo 20-22hr    45 embryo 22-24hr    48 larva L1    40 larva L2    45 larva L3 12hr old    31 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    50 larva L3 puffstage 7-9    65 white prepupae new    65 white prepupae 12hr    70 white prepupae 24hr    63 pupae 2d postWPP    68 pupae 3d postWPP    43 pupae 4d postWPP    29 adult male 01day    34 adult male 05day    33 adult male 30day    30 adult female 01day    35 adult female 05day    50 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (73) embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr  (34) embryo 10-12hr  (59) embryo 12-14hr  (63) embryo 14-16hr  (63) embryo 16-18hr  (57) embryo 18-20hr  (53) embryo 20-22hr  (45) embryo 22-24hr  (48) larva L1  (40) larva L2  (45) larva L3 12hr old  (31) larva L3 puffstage 1-2  (37) larva L3 puffstage 3-6  (50) larva L3 puffstage 7-9  (65) white prepupae new  (65) white prepupae 12hr  (70) white prepupae 24hr  (63) pupae 2d postWPP  (68) pupae 3d postWPP  (43) pupae 4d postWPP  (29) adult male 01day  (34) adult male 05day  (33) adult male 30day  (30) adult female 01day  (35) adult female 05day  (50) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr    34 embryo 10-12hr    59 embryo 12-14hr    63 embryo 14-16hr    63 embryo 16-18hr    57 embryo 18-20hr    53 embryo 20-22hr    45 embryo 22-24hr    48 larva L1    40 larva L2    45 larva L3 12hr old    31 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    50 larva L3 puffstage 7-9    65 white prepupae new    65 white prepupae 12hr    70 white prepupae 24hr    63 pupae 2d postWPP    68 pupae 3d postWPP    43 pupae 4d postWPP    29 adult male 01day    34 adult male 05day    33 adult male 30day    30 adult female 01day    35 adult female 05day    50 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr    34 embryo 10-12hr    59 embryo 12-14hr    63 embryo 14-16hr    63 embryo 16-18hr    57 embryo 18-20hr    53 embryo 20-22hr    45 embryo 22-24hr    48 larva L1    40 larva L2    45 larva L3 12hr old    31 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    50 larva L3 puffstage 7-9    65 white prepupae new    65 white prepupae 12hr    70 white prepupae 24hr    63 pupae 2d postWPP    68 pupae 3d postWPP    43 pupae 4d postWPP    29 adult male 01day    34 adult male 05day    33 adult male 30day    30 adult female 01day    35 adult female 05day    50 adult female 30day    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr    34 embryo 10-12hr    59 embryo 12-14hr    63 embryo 14-16hr    63 embryo 16-18hr    57 embryo 18-20hr    53 embryo 20-22hr    45 embryo 22-24hr    48 larva L1    40 larva L2    45 larva L3 12hr old    31 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    50 larva L3 puffstage 7-9    65 white prepupae new    65 white prepupae 12hr    70 white prepupae 24hr    63 pupae 2d postWPP    68 pupae 3d postWPP    43 pupae 4d postWPP    29 adult male 01day    34 adult male 05day    33 adult male 30day    30 adult female 01day    35 adult female 05day    50 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (73) embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr  (34) embryo 10-12hr  (59) embryo 12-14hr  (63) embryo 14-16hr  (63) embryo 16-18hr  (57) embryo 18-20hr  (53) embryo 20-22hr  (45) embryo 22-24hr  (48) larva L1  (40) larva L2  (45) larva L3 12hr old  31 larva L3 puffstage 1-2  (37) larva L3 puffstage 3-6  (50) larva L3 puffstage 7-9  (65) white prepupae new  (65) white prepupae 12hr  (70) white prepupae 24hr  (63) pupae 2d postWPP  (68) pupae 3d postWPP  (43) pupae 4d postWPP  29 adult male 01day  (34) adult male 05day  (33) adult male 30day  30 adult female 01day  (35) adult female 05day  (50) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr    34 embryo 10-12hr    59 embryo 12-14hr    63 embryo 14-16hr    63 embryo 16-18hr    57 embryo 18-20hr    53 embryo 20-22hr    45 embryo 22-24hr    48 larva L1    40 larva L2    45 larva L3 12hr old    31 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    50 larva L3 puffstage 7-9    65 white prepupae new    65 white prepupae 12hr    70 white prepupae 24hr    63 pupae 2d postWPP    68 pupae 3d postWPP    43 pupae 4d postWPP    29 adult male 01day    34 adult male 05day    33 adult male 30day    30 adult female 01day    35 adult female 05day    50 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    21 embryo 04-06hr    10 embryo 06-08hr    22 embryo 08-10hr    34 embryo 10-12hr    59 embryo 12-14hr    63 embryo 14-16hr    63 embryo 16-18hr    57 embryo 18-20hr    53 embryo 20-22hr    45 embryo 22-24hr    48 larva L1    40 larva L2    45 larva L3 12hr old    31 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    50 larva L3 puffstage 7-9    65 white prepupae new    65 white prepupae 12hr    70 white prepupae 24hr    63 pupae 2d postWPP    68 pupae 3d postWPP    43 pupae 4d postWPP    29 adult male 01day    34 adult male 05day    33 adult male 30day    30 adult female 01day    35 adult female 05day    50 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    64 embryonic 1182-4H    115 embryonic GM2    70 embryonic Kc167    49 embryonic S1    97 embryonic S3    73 leg disc CME L1    111 wing disc CME-W2    52 wing disc ML-DmD8    51 wing disc ML-DmD9    119 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    51 wing disc ML-DmD32    94 haltere disc ML-DmD17-c3    101 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    62 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    57 tumorous blood cells mbn2    60 ovary fGS/OSS    84 ovary OSC    65 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  (64) embryonic 1182-4H  (115) embryonic GM2  (70) embryonic Kc167  (49) embryonic S1  (97) embryonic S3  (73) leg disc CME L1  (111) wing disc CME-W2  (52) wing disc ML-DmD8  (51) wing disc ML-DmD9  (119) wing disc ML-DmD16-c3  (94) wing disc ML-DmD21  (51) wing disc ML-DmD32  (94) haltere disc ML-DmD17-c3  (101) eye-antennal disc ML-DmD11  (60) antennal disc ML-DmD20-c5  (62) mixed discs ML-DmD4-c1  (64) CNS ML-DmBG1-c1  (87) CNS ML-DmBG2-c2  (57) tumorous blood cells mbn2  (60) ovary fGS/OSS  (84) ovary OSC  (65) ovary OSS  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    64 embryonic 1182-4H  (115) embryonic GM2    70 embryonic Kc167    49 embryonic S1    97 embryonic S3    73 leg disc CME L1  (111) wing disc CME-W2    52 wing disc ML-DmD8    51 wing disc ML-DmD9  (119) wing disc ML-DmD16-c3    94 wing disc ML-DmD21    51 wing disc ML-DmD32    94 haltere disc ML-DmD17-c3  101 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    62 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    57 tumorous blood cells mbn2    60 ovary fGS/OSS    84 ovary OSC    65 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    64 embryonic 1182-4H    115 embryonic GM2    70 embryonic Kc167    49 embryonic S1    97 embryonic S3    73 leg disc CME L1    111 wing disc CME-W2    52 wing disc ML-DmD8    51 wing disc ML-DmD9    119 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    51 wing disc ML-DmD32    94 haltere disc ML-DmD17-c3    101 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    62 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    57 tumorous blood cells mbn2    60 ovary fGS/OSS    84 ovary OSC    65 ovary OSS    59 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    64 embryonic 1182-4H    115 embryonic GM2    70 embryonic Kc167    49 embryonic S1    97 embryonic S3    73 leg disc CME L1    111 wing disc CME-W2    52 wing disc ML-DmD8    51 wing disc ML-DmD9    119 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    51 wing disc ML-DmD32    94 haltere disc ML-DmD17-c3    101 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    62 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    57 tumorous blood cells mbn2    60 ovary fGS/OSS    84 ovary OSC    65 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  (64) embryonic 1182-4H  (115) embryonic GM2  (70) embryonic Kc167  (49) embryonic S1  (97) embryonic S3  (73) leg disc CME L1  (111) wing disc CME-W2  (52) wing disc ML-DmD8  (51) wing disc ML-DmD9  (119) wing disc ML-DmD16-c3  (94) wing disc ML-DmD21  (51) wing disc ML-DmD32  (94) haltere disc ML-DmD17-c3  (101) eye-antennal disc ML-DmD11  (60) antennal disc ML-DmD20-c5  (62) mixed discs ML-DmD4-c1  (64) CNS ML-DmBG1-c1  (87) CNS ML-DmBG2-c2  (57) tumorous blood cells mbn2  (60) ovary fGS/OSS  (84) ovary OSC  (65) ovary OSS  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    64 embryonic 1182-4H  115 embryonic GM2    70 embryonic Kc167    49 embryonic S1    97 embryonic S3    73 leg disc CME L1  111 wing disc CME-W2    52 wing disc ML-DmD8    51 wing disc ML-DmD9  119 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    51 wing disc ML-DmD32    94 haltere disc ML-DmD17-c3  101 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    62 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    57 tumorous blood cells mbn2    60 ovary fGS/OSS    84 ovary OSC    65 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    64 embryonic 1182-4H    115 embryonic GM2    70 embryonic Kc167    49 embryonic S1    97 embryonic S3    73 leg disc CME L1    111 wing disc CME-W2    52 wing disc ML-DmD8    51 wing disc ML-DmD9    119 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    51 wing disc ML-DmD32    94 haltere disc ML-DmD17-c3    101 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    62 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    57 tumorous blood cells mbn2    60 ovary fGS/OSS    84 ovary OSC    65 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    35 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    26 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (38) cold shock, 4-day adult  (35) heat shock, 4-day adult  (34) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3  (41) Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3  26 Copper 15 mM 48 hrs, 4-day adult  (27) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3  (28) Ethanol 10% 3 hrs, larvae L3  (29) Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (35) Rotenone 2 μg 12 hrs, larvae L3  (27) Rotenone 8 μg 12 hrs, larvae L3  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    35 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    26 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    35 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    26 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    35 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    26 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (38) cold shock, 4-day adult  (35) heat shock, 4-day adult  (34) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3  (41) Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3  26 Copper 15 mM 48 hrs, 4-day adult  27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3  28 Ethanol 10% 3 hrs, larvae L3  29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (35) Rotenone 2 μg 12 hrs, larvae L3  27 Rotenone 8 μg 12 hrs, larvae L3  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    35 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    26 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    35 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    26 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD13018 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010235 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5433-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Klc Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | recessive Klc8ex94 Klcunspecified lethal | pupal stage | recessive Klc59A viable, with Scer\GAL4pnr-MD237 KlcGD11649 Other Phenotypes Allele paralytic | larval stage | recessive Klcunspecified visible, with Scer\GAL4pnr-MD237 KlcGD11649 Phenotype manifest in Allele embryonic/larval nervous system Klc8ex94 eye | somatic clone Klc8ex94 trichogen cell, with Scer\GAL4pnr-MD237 KlcGD11649
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Klc Class Mutagen Stocks Known lesion Klcc02312 piggyBac transposase 2 -- Klc59A Delta2-3 1 Yes Klc8ex94 1 Yes Klc8ex25 Delta2-3 0 Yes Klcf01010 piggyBac transposase 0 -- Klcunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Klc Class Mutagen Stocks Known lesion KlcGD11649 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes KlcGL00535 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes KlcHMS00883 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes KlcHMS02429 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes KlcdsRNA.cLa in vitro construct - RNAi 0 Yes KlcGEN in vitro construct - genomic fragment 0 Yes KlcNIG.5433R in vitro construct - RNAi 0 Yes KlcScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes KlcUbi-p63E.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)34ex5 (Martin et al., 1999, Horiuchi et al., 2005) Df(3L)Exel6117 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11649} NA P{TRiP.GL00535} NA P{TRiP.HMS00883} NA P{TRiP.HMS02429} NA P{UAS-Klc.MYC} NA characterization construct P{GEN-Klc} NA P{NIG.5433R} NA P{Ubi-p63E-Klc.T:Myc} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Klcc02312 NA PBac{WH}Klcf01010 NA insertion of enhancer trap P{lacW}Klc59A No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
microtubule motor activity inferred from direct assay (Ali et al., 2008)
Biological Process
CV term Evidence References
microtubule-based movement inferred from direct assay (Ali et al., 2008) regulation of cell cycle inferred from direct assay (Guest et al., 2011)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
microtubule motor activity inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AF055665 (FlyBase, 1992-)
Biological Process
CV term Evidence References
microtubule-based movement inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AF055665 (FlyBase, 1992-) microtubule-based process non-traceable author statement (Swiss-Prot Project Members, 1995.9.1)
Cellular Component
CV term Evidence References
kinesin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AF055665 (FlyBase, 1992-) non-traceable author statement (Gauger, 1993, Swiss-Prot Project Members, 1995.9.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Klc - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - CG3714 experimental knowledge based (Guruharsha et al., 2011) Klc - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Khc anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based, peptide massfingerprinting (Loiseau et al., 2010, Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Klc - MSBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Pat1 anti tag coimmunoprecipitation, anti tag western blot (Loiseau et al., 2010) Klc - Prosα2 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosα4 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosα5 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosα6 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosβ1 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosβ2 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosβ3 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosβ4 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosβ5 experimental knowledge based (Guruharsha et al., 2011) Klc - Prosβ6 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Klc - Prosβ7 experimental knowledge based (Guruharsha et al., 2011) Klc - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - larp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Klc - tkv experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Klc allele Gene References Klcunspecified Dhc64C (Martin et al., 1999) Khc (Martin et al., 1999) unspecified Aplip1 (Gassman et al., 1997, Gassman et al., 1999, Horiuchi et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64793 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010235 DroID - A comprehensive database of gene and protein interactions. • FBgn0010235 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39445
Orthologs
OrthoDB Orthologs (53) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z0BRC Dipteran inclusive ortholog search EOG67SSP3 Insect inclusive ortholog search EOG6T1GGN Arthropod inclusive ortholog search EOG6DBRVS Metazoa inclusive ortholog search EOG6H7F4X
Orthologs in Drosophila Species (EOG6Z0BRC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Klc     Drosophila simulans   Dsim\GD12703 Y   Drosophila sechellia   Dsec\GM24634 Y   Drosophila erecta   Dere\GG13809 Y   Drosophila yakuba   Dyak\GE20101 Y   Drosophila ananassae   Dana\GF10870 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18878 Y   Drosophila persimilis   Dper\GL24935 Y   Drosophila willistoni   Dwil\GK20263 Y   Drosophila virilis   Dvir\GJ13801 Y   Drosophila mojavensis   Dmoj\GI11926 Y   Drosophila grimshawi   Dgri\GH16833 Y
Orthologs in non-Drosophila Dipterans (EOG67SSP3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012472   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005502   Anopheles gambiae Malaria mosquito  Agam\AGAP010258   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015771
Orthologs in non-Dipteran Insects (EOG6T1GGN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53365   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005622   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11761   Atta cephalotes Leafcutter ant  Acep\ACEP27331   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22505   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22179   Linepithema humile Argentine ant  Lhum\LH12957   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17386   Solenopsis invicta Red fire ant  Sinv\SINV19289   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010226   Acyrthosiphon pisum Pea aphid  Apim\ACYPI086822   Bombyx mori Silkmoth  Bmor\BGIBMGA008408   Pediculus humanus Human body louse  Phum\PHUM287490   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07992
Orthologs in non-Insect Arthropods (EOG6DBRVS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_187724   Ixodes scapularis Deer tick  Isca\ISCW011646
Orthologs in non-Arthropod Metazoa (EOG6H7F4X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\klc-1   Caenorhabditis elegans Nematode  Cele\C18C4.10   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018898gn   Danio rerio Zebrafish  Drer\CU929286.1   Danio rerio Zebrafish  Drer\MGC162288   Danio rerio Zebrafish  Drer\CU929286.1   Danio rerio Zebrafish  Drer\ENSDARG00000009796   Danio rerio Zebrafish  Drer\klc3   Xenopus tropicalis Western clawed frog  Xtro\klc1   Gallus gallus Domestic chicken  Ggal\KLC1   Gallus gallus Domestic chicken  Ggal\KLC4   Mus musculus House mouse  Mmus\Klc2   Mus musculus House mouse  Mmus\Klc4   Mus musculus House mouse  Mmus\Klc1   Rattus norvegicus Norway rat  Rnor\Klc2   Rattus norvegicus Norway rat  Rnor\Klc4   Rattus norvegicus Norway rat  Rnor\Klc1   Homo sapiens Human  Hsap\KLC2   Homo sapiens Human  Hsap\ENSG00000126214   Homo sapiens Human  Hsap\ENSG00000256500   Homo sapiens Human  Hsap\KLC4
Human Orthologs (4)
Gene OMIM HGNC Hsap\KLC2     Hsap\ENSG00000126214     Hsap\ENSG00000256500     Hsap\KLC4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12703 Drosophila sechellia Dsec\GM24634 Drosophila erecta Dere\GG13809 Drosophila yakuba Dyak\GE20101 Drosophila ananassae Dana\GF10870 Drosophila pseudoobscura pseudoobscura Dpse\GA18878 Drosophila persimilis Dper\GL24935 Drosophila willistoni Dwil\GK20263 Drosophila virilis Dvir\GJ13801 Drosophila mojavensis Dmoj\GI11926 Drosophila grimshawi Dgri\GH16833
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	31997 w*; Klc8ex94/TM3, Sb1 33934 y1 sc* v1; P{TRiP.HMS00883}attP2 36795 y1 sc* v1; P{TRiP.GL00535}attP40 42597 y1 sc* v1; P{TRiP.HMS02429}attP40 10883 w1118; PBac{PB}Klcc02312/TM6B, Tb1 31996 w*; P{lacW}Klc59A P{FRT(whs)}2A/TM6B, Tb+
Harvard	- PBac{PB}Klcc02312
VDRC	v22125 w1118; P{GD11649}v22125 v39583 w1118; P{GD11649}v39583 v22126 w1118; P{GD11649}v22126/TM3
Genomic Clones ( 1 )
	BACR20I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13018
Other clones	DPiM_LD13018
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	19610 34534 149738 156387 524753 CK01.29B.D6 CK01.55B.G9 CK01.82D.C12 CK01.92B.H8 CK01.93D.C6 CK01.94D.F1 CK01.110D.B10 CK01.117C.E2 CK01.119D.F12 CK01.120A.D4 CK01.142C.H10 Dmel_dig_018398_0652_1228 Dmel_neb_011221_0634_1588 EK005849 EK025947 EK072164 EK073143 EK073821 EK085101 EK132638 ESG015b.E21_F04 IP01749 IP01751 RP003047876 RP003100551 RP003104595 RP003127119 RP003144123 RP003164716 RP003191686 RP003204710 RP003208510 RP003213333 RP003214008 RP003215531 RP003216157 RP003233691 RP003244693 RP003248687 RP003254787 RP003265138 RP003287618 RP003315722 RP003354007 RP003365410 RP003436158 RP003467015 RP003490304 RP003496203 RP003501608 RP003508586 RP003564716 RP003565471 RP003592658 RP003599407 RP003662140 RP003673242
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010235 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39445
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Khc is required for all cytoplasmic movements in the oocyte and for the posterior localisation of Dhc64C. Klc is not required for any of the functions of kinesin in the oocyte. (Palacios and St. Johnston, 2002) syd directly binds Klc via the Klc tetratricopeptide repeat. (Bowman et al., 2000) Loss of Klc function results in progressive lethargy, crawling defects, and paralysis followed by death at the end of the second larval instar stage. Klc mutant axons contain large aggregates of membranous organelles in segmental nerve axons. (Gindhart et al., 1998) Klc is an essential gene, with mutants dying during larval and pupal stages of development. A subset of alleles exhibit behavioural phenotype of sluggish crawling during the third larval instar. These phenotypes are similar to those of Khc mutants. (Gindhart et al., 1995) Isolated from a Drosophila head cDNA expression library using the Khc tail, which binds specifically to Klc in blot overlays, as a probe. (Gauger and Goldstein, 1993) Klc has been cloned and sequenced. (Gauger and Goldstein, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079325 NM_001274851 NM_001274852 RefSeq (Proteins) • NP_524049 NP_001261780 NP_001261781 DDBJ / EMBL / GenBank • AAA02481 AAA28669 AAF49890 AAL28712 AGB94473 AGB94474 AY061164 CZ483495 L11013 L11328 Entrez Gene - A searchable database of RefSeq genes. • 39445 UniProtKB/Swiss-Prot • P46824
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR2 (IPR013105) Kinesin light chain (IPR002151) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Rabaptin, GTPase-Rab5 binding domain (IPR015390) Kinesin light chain repeat (IPR015792) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD13018
Linkouts
	BioGRID - A database of protein and genetic interactions • 64793 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010235 DroID - A comprehensive database of gene and protein interactions. • FBgn0010235 DRSC - Results from RNAi screens. • FBgn0010235 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010235 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5433-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010235 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39445 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39445 modMine - Data generated by the modENCODE project. • FBgn0010235
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG5433 (Mount, 2001.8.14, Goldstein and Gunawardena, 2000, Ni et al., 2011.7.19, Gandhi et al., 2007, Hughes et al., 2008, Ni et al., 2010.12.1) DKLC (Taru et al., 2002) kinesin (Carter and Cross, 2005, Molloy and Schmitz, 2005) KLC (Ling, 2004, Ling et al., 2004, Gauger and Goldstein, 1993, Glater et al., 2006, Fisher et al., 2012) klc (Palacios and St. Johnston, 2002, Desai et al., 1996, Gindhart et al., 1994, Gindhart et al., 1995, Mische et al., 2007, Falzone et al., 2010, Ganguly et al., 2012, Metzger et al., 2012, Reis et al., 2012) Klc (Horiuchi et al., 2007, Shubeita et al., 2008, Toda et al., 2008, Vendra et al., 2007, Boylan et al., 2008, Loiseau et al., 2010, Guest et al., 2011)
Name Synonym	kinesin (Short et al., 2005, Gindhart et al., 2005, de Heredia and Jansen, 2004) kinesin-1 (Horiuchi et al., 2007, Benseñor et al., 2010) Kinesin-1 (Vendra et al., 2007) Kinesin 1 light chain (Jolly et al., 2010) kinesin-1 light chain (Fisher et al., 2012) kinesin I (Welte, 2004) kinesin light chain (Gauger, 1993, Gauger, 1993, Glater et al., 2006, Favors and Hales, 2008, Josowitz et al., 2008, Ali et al., 2008, Boylan et al., 2008, Johnson et al., 2009) Kinesin light chain (Loiseau et al., 2010) kinesin light chain subunit of kinesin-1 (Horiuchi et al., 2007)
Secondary FlyBase IDs
References ( 100 )
Generate a list of	All references relating to this gene ( 100 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 11 ) Review  ( 12 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 17 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Fisher et al., 2012, J. Struct. Biol. 177(3): 602--612 Evidence that the kinesin light chain domain contains tetratricopeptide repeat units. [FBrf0217804] Ganguly et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(38): 15109--15114 Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. [FBrf0219481] Metzger et al., 2012, Nature 484(7392): 120--124 MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function. [FBrf0218014] Reis et al., 2012, Mol. Biol. Cell 23(9): 1700--1714 Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. [FBrf0218178] Guest et al., 2011, BMC Syst. Biol. 5(1): 65 A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...