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Gene Dmel\Lac

General Information
Symbol	Dmel\Lac	Species	D. melanogaster
Name	Lachesin	Annotation symbol	CG12369
Feature type	protein_coding_gene	FlyBase ID	FBgn0010238
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	bulb, l(2)k11012
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49A6-49A7	Sequence location	2R:8,340,696..8,353,154 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lachesin is referred to in FlyBase by the symbol Dmel\Lac (CG12369, FBgn0010238). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: morphogenesis of embryonic epithelium; homophilic cell adhesion; regulation of tube size, open tracheal system; maintenance of epithelial integrity, open tracheal system; open tracheal system development. 14 alleles are reported. The phenotypes of these alleles are annotated with: presumptive embryonic salivary gland; dorsal group branch precursor; embryonic/larval dorsal trunk; presumptive embryonic/larval tracheal system; embryonic/larval tracheal system; lateral group branch precursor; dorsal trunk primordium; embryonic/larval transverse connective. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval fat body, adult spermathecae, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628336_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Lac. Gene sequence location is 2R:8340696..8353154.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA07452 BKN27469
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49A6-49A7   Limits computationally determined from genome sequence between P{lacW}l(2)k11404k11404 and P{lacW}fdlk17040
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Lac for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lac-RA FBtr0087933  NM_078989   2174   359 Lac-RB FBtr0087932  NM_165906   1853   252
Additional Transcript Data & Comments
Reported size (kB)	2.1 (longest cDNA) (Karlstrom et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lac-PA   FBpp0087044   39.9   359   5.09     NP_523713   AAF58506 Lac-PB   FBpp0087043   28.2   252   4.58     NP_725173   AAM68689
Additional Polypeptide Data & Comments
Reported size (kDa)	359 (aa) (Karlstrom et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202344   AA246948   AA392729   AA538837   AA540566   AA540952   AA541049   AA979172   AE013599 AAF58506   AE013599 AAM68689   AI295071   AI515209   AW943188   AX093894   AY051829 AAK93253   BG636977   BH901112   BI163483   BI165476   BI165943   BI166517   BI167320   BI168873   BI212191   BI212685   BI212906   BI213319   BI213833   BI214044   BI215742   BI216799   BI216836   BI227847   BI228174   BI228409   BI228487   BI228782   BI229269   BI229322   BI232860   BI232865   BI234999   BI235519   BI237004   BI237069   BI237105   BI237181   BI237453   BI238755   BI239511   BI239581   BI356301   BI357020   BI357346   BI358127   BI361841   BI361924   BI363424   BI363476   BI363767   BI364117   BI364215   BI364241   BI365095   BI365334   BI365799   BI365823   BI366277   BI366358   BI366662   BI370820   BI373844   BI373845   BI375591   BI481719   BI484493   BI484508   BI486791   BI567675   BI568354   BI578843   BI579194   BI579222   BI579720   BI589234   BI589426   BI592365   BI604703   BI605836   BI613653   BI613657   BI617248   BI617255   BI624027   BI624332   BI625438   BI628782   BI634211   BI638845   BP548908   BP556640   BT003177 AAO24932   BT044422   CA804091   CA806401   CO190004   CO190744   CO266497   CO272912   CO275559   CO278746   CO283419   CO284531   CO286271   CO286273   CO286281   CO286965   CO287049   CO288776   CO289091   CO289650   CO290905   CO295537   CO298889   CO301438   CO301807   CO310335   CO310692   CO312320   CO312526   CO320223   CO320373   CO323288   CZ470624   CZ470625   CZ471615   CZ480398   DN154433   EC057212   EC058514   EC059900   EC061000   EC062025   EC064276   EC074240   EC075019   EC076091   EC077884   EC080026   EC080056   EC081397   EC082272   EC195489   EC196054   EC196243   EC198538   EC198956   EC201499   EC207442   EC207480   EC211394   EC215980   EC216046   EC217368   EC221613   EC222078   EC225081   EC228143   EC230901   EC231495   EC233132   EC246070   EC246481   EC246513   EC248099   ES692137   ES692142   ES692148   GH739076   GH739290   GH741219   GH741570   GH741577   GH741746   GH742005   GH742253   GH742665   GH742904   GH742926   GH743114   GH743286   GH743446   GH744841   GH745923   GH746593   GH746655   GH746762   GH747298   GH761668   GH762883   GH763771   GH764036   GH764418   GH764929   GH765075   GH765272   GH765649   GH766200   GH767061   GH767235   GH768185   GH769578   L13255 AAC37184
UniProtKB/Swiss-Prot	Q24372
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010238    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010238 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010238 expression level Developmental Stage   Expression Level embryo 00-02hr    5052 embryo 02-04hr    29405 embryo 04-06hr    29708 embryo 06-08hr    28941 embryo 08-10hr    22229 embryo 10-12hr    23006 embryo 12-14hr    16808 embryo 14-16hr    14602 embryo 16-18hr    10543 embryo 18-20hr    7614 embryo 20-22hr    4037 embryo 22-24hr    3956 larva L1    3589 larva L2    2622 larva L3 12hr old    1868 larva L3 puffstage 1-2    2305 larva L3 puffstage 3-6    4401 larva L3 puffstage 7-9    5666 white prepupae new    8222 white prepupae 12hr    11283 white prepupae 24hr    19577 pupae 2d postWPP    8018 pupae 3d postWPP    5619 pupae 4d postWPP    2405 adult male 01day    2318 adult male 05day    2526 adult male 30day    2879 adult female 01day    2981 adult female 05day    2596 adult female 30day    2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5052) embryo 02-04hr  (29405) embryo 04-06hr  (29708) embryo 06-08hr  (28941) embryo 08-10hr  (22229) embryo 10-12hr  (23006) embryo 12-14hr  (16808) embryo 14-16hr  (14602) embryo 16-18hr  (10543) embryo 18-20hr  (7614) embryo 20-22hr  (4037) embryo 22-24hr  (3956) larva L1  (3589) larva L2  (2622) larva L3 12hr old  (1868) larva L3 puffstage 1-2  (2305) larva L3 puffstage 3-6  (4401) larva L3 puffstage 7-9  (5666) white prepupae new  (8222) white prepupae 12hr  (11283) white prepupae 24hr  (19577) pupae 2d postWPP  (8018) pupae 3d postWPP  (5619) pupae 4d postWPP  (2405) adult male 01day  (2318) adult male 05day  (2526) adult male 30day  (2879) adult female 01day  (2981) adult female 05day  (2596) adult female 30day  (2310) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5052) embryo 02-04hr  (29405) embryo 04-06hr  (29708) embryo 06-08hr  (28941) embryo 08-10hr  (22229) embryo 10-12hr  (23006) embryo 12-14hr  (16808) embryo 14-16hr  (14602) embryo 16-18hr  (10543) embryo 18-20hr  (7614) embryo 20-22hr  (4037) embryo 22-24hr  (3956) larva L1  (3589) larva L2  (2622) larva L3 12hr old  (1868) larva L3 puffstage 1-2  (2305) larva L3 puffstage 3-6  (4401) larva L3 puffstage 7-9  (5666) white prepupae new  (8222) white prepupae 12hr  (11283) white prepupae 24hr  (19577) pupae 2d postWPP  (8018) pupae 3d postWPP  (5619) pupae 4d postWPP  (2405) adult male 01day  (2318) adult male 05day  (2526) adult male 30day  (2879) adult female 01day  (2981) adult female 05day  (2596) adult female 30day  (2310) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5052 embryo 02-04hr  (29405) embryo 04-06hr  (29708) embryo 06-08hr  (28941) embryo 08-10hr  (22229) embryo 10-12hr  (23006) embryo 12-14hr  (16808) embryo 14-16hr  (14602) embryo 16-18hr  10543 embryo 18-20hr    7614 embryo 20-22hr    4037 embryo 22-24hr    3956 larva L1    3589 larva L2    2622 larva L3 12hr old    1868 larva L3 puffstage 1-2    2305 larva L3 puffstage 3-6    4401 larva L3 puffstage 7-9    5666 white prepupae new    8222 white prepupae 12hr  (11283) white prepupae 24hr  (19577) pupae 2d postWPP    8018 pupae 3d postWPP    5619 pupae 4d postWPP    2405 adult male 01day    2318 adult male 05day    2526 adult male 30day    2879 adult female 01day    2981 adult female 05day    2596 adult female 30day    2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5052 embryo 02-04hr    29405 embryo 04-06hr    29708 embryo 06-08hr    28941 embryo 08-10hr    22229 embryo 10-12hr    23006 embryo 12-14hr    16808 embryo 14-16hr    14602 embryo 16-18hr    10543 embryo 18-20hr    7614 embryo 20-22hr    4037 embryo 22-24hr    3956 larva L1    3589 larva L2    2622 larva L3 12hr old    1868 larva L3 puffstage 1-2    2305 larva L3 puffstage 3-6    4401 larva L3 puffstage 7-9    5666 white prepupae new    8222 white prepupae 12hr    11283 white prepupae 24hr    19577 pupae 2d postWPP    8018 pupae 3d postWPP    5619 pupae 4d postWPP    2405 adult male 01day    2318 adult male 05day    2526 adult male 30day    2879 adult female 01day    2981 adult female 05day    2596 adult female 30day    2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010238 expression level Developmental Stage   Expression Level embryo 00-02hr    5052 embryo 02-04hr    29405 embryo 04-06hr    29708 embryo 06-08hr    28941 embryo 08-10hr    22229 embryo 10-12hr    23006 embryo 12-14hr    16808 embryo 14-16hr    14602 embryo 16-18hr    10543 embryo 18-20hr    7614 embryo 20-22hr    4037 embryo 22-24hr    3956 larva L1    3589 larva L2    2622 larva L3 12hr old    1868 larva L3 puffstage 1-2    2305 larva L3 puffstage 3-6    4401 larva L3 puffstage 7-9    5666 white prepupae new    8222 white prepupae 12hr    11283 white prepupae 24hr    19577 pupae 2d postWPP    8018 pupae 3d postWPP    5619 pupae 4d postWPP    2405 adult male 01day    2318 adult male 05day    2526 adult male 30day    2879 adult female 01day    2981 adult female 05day    2596 adult female 30day    2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5052) embryo 02-04hr  (29405) embryo 04-06hr  (29708) embryo 06-08hr  (28941) embryo 08-10hr  (22229) embryo 10-12hr  (23006) embryo 12-14hr  (16808) embryo 14-16hr  (14602) embryo 16-18hr  (10543) embryo 18-20hr  (7614) embryo 20-22hr  (4037) embryo 22-24hr  (3956) larva L1  (3589) larva L2  (2622) larva L3 12hr old  (1868) larva L3 puffstage 1-2  (2305) larva L3 puffstage 3-6  (4401) larva L3 puffstage 7-9  (5666) white prepupae new  (8222) white prepupae 12hr  (11283) white prepupae 24hr  (19577) pupae 2d postWPP  (8018) pupae 3d postWPP  (5619) pupae 4d postWPP  (2405) adult male 01day  (2318) adult male 05day  (2526) adult male 30day  (2879) adult female 01day  (2981) adult female 05day  (2596) adult female 30day  (2310) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5052) embryo 02-04hr  (29405) embryo 04-06hr  (29708) embryo 06-08hr  (28941) embryo 08-10hr  (22229) embryo 10-12hr  (23006) embryo 12-14hr  (16808) embryo 14-16hr  (14602) embryo 16-18hr  (10543) embryo 18-20hr  (7614) embryo 20-22hr  (4037) embryo 22-24hr  (3956) larva L1  (3589) larva L2  (2622) larva L3 12hr old  1868 larva L3 puffstage 1-2  2305 larva L3 puffstage 3-6  (4401) larva L3 puffstage 7-9  (5666) white prepupae new  (8222) white prepupae 12hr  (11283) white prepupae 24hr  (19577) pupae 2d postWPP  (8018) pupae 3d postWPP  (5619) pupae 4d postWPP  2405 adult male 01day  2318 adult male 05day  (2526) adult male 30day  (2879) adult female 01day  (2981) adult female 05day  (2596) adult female 30day  2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5052 embryo 02-04hr  (29405) embryo 04-06hr  (29708) embryo 06-08hr  (28941) embryo 08-10hr  (22229) embryo 10-12hr  (23006) embryo 12-14hr  16808 embryo 14-16hr  14602 embryo 16-18hr  10543 embryo 18-20hr    7614 embryo 20-22hr    4037 embryo 22-24hr    3956 larva L1    3589 larva L2    2622 larva L3 12hr old    1868 larva L3 puffstage 1-2    2305 larva L3 puffstage 3-6    4401 larva L3 puffstage 7-9    5666 white prepupae new    8222 white prepupae 12hr  11283 white prepupae 24hr  19577 pupae 2d postWPP    8018 pupae 3d postWPP    5619 pupae 4d postWPP    2405 adult male 01day    2318 adult male 05day    2526 adult male 30day    2879 adult female 01day    2981 adult female 05day    2596 adult female 30day    2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5052 embryo 02-04hr    29405 embryo 04-06hr    29708 embryo 06-08hr    28941 embryo 08-10hr    22229 embryo 10-12hr    23006 embryo 12-14hr    16808 embryo 14-16hr    14602 embryo 16-18hr    10543 embryo 18-20hr    7614 embryo 20-22hr    4037 embryo 22-24hr    3956 larva L1    3589 larva L2    2622 larva L3 12hr old    1868 larva L3 puffstage 1-2    2305 larva L3 puffstage 3-6    4401 larva L3 puffstage 7-9    5666 white prepupae new    8222 white prepupae 12hr    11283 white prepupae 24hr    19577 pupae 2d postWPP    8018 pupae 3d postWPP    5619 pupae 4d postWPP    2405 adult male 01day    2318 adult male 05day    2526 adult male 30day    2879 adult female 01day    2981 adult female 05day    2596 adult female 30day    2310 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010238    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010238 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval fat body, adult spermathecae, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010238 expression level Tissue   Expression Level Larval Central Nervous System    874.35 Larval Midgut    71.6 Larval Hindgut    902.7 Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland    896 Larval Trachea    1569.625 Larval Carcass    605.325 Adult Head    518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop    1195.3 Adult Midgut    48 Adult Hindgut    736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland    969.9 Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary    501.4 Adult Testis    245 Adult Male Accessory Gland    622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (874.35) Larval Midgut    71.6 Larval Hindgut  (902.7) Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland  (896) Larval Trachea  (1569.625) Larval Carcass  (605.325) Adult Head  518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop  (1195.3) Adult Midgut    48 Adult Hindgut  (736.7) Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland  (969.9) Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary  501.4 Adult Testis    245 Adult Male Accessory Gland  (622.3) Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    874.35 Larval Midgut    71.6 Larval Hindgut    902.7 Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland    896 Larval Trachea  (1569.625) Larval Carcass    605.325 Adult Head    518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop  (1195.3) Adult Midgut    48 Adult Hindgut    736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland    969.9 Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary    501.4 Adult Testis    245 Adult Male Accessory Gland    622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    874.35 Larval Midgut    71.6 Larval Hindgut    902.7 Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland    896 Larval Trachea    1569.625 Larval Carcass    605.325 Adult Head    518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop    1195.3 Adult Midgut    48 Adult Hindgut    736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland    969.9 Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary    501.4 Adult Testis    245 Adult Male Accessory Gland    622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010238 expression level Tissue   Expression Level Larval Central Nervous System    874.35 Larval Midgut    71.6 Larval Hindgut    902.7 Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland    896 Larval Trachea    1569.625 Larval Carcass    605.325 Adult Head    518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop    1195.3 Adult Midgut    48 Adult Hindgut    736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland    969.9 Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary    501.4 Adult Testis    245 Adult Male Accessory Gland    622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (874.35) Larval Midgut    71.6 Larval Hindgut  (902.7) Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland  (896) Larval Trachea  (1569.625) Larval Carcass  605.325 Adult Head  518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop  (1195.3) Adult Midgut    48 Adult Hindgut  736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland  (969.9) Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary  501.4 Adult Testis    245 Adult Male Accessory Gland  622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    874.35 Larval Midgut    71.6 Larval Hindgut    902.7 Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland    896 Larval Trachea  1569.625 Larval Carcass    605.325 Adult Head    518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop  1195.3 Adult Midgut    48 Adult Hindgut    736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland    969.9 Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary    501.4 Adult Testis    245 Adult Male Accessory Gland    622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    874.35 Larval Midgut    71.6 Larval Hindgut    902.7 Larval Malpighian Tubules    16.4 Larval Fat Body    172.7 Larval Salivary Gland    896 Larval Trachea    1569.625 Larval Carcass    605.325 Adult Head    518.9 Adult Eye    467.8 Adult Brain    248.7 Adult Thoracic-Abdominal Ganglion    144.8 Adult Crop    1195.3 Adult Midgut    48 Adult Hindgut    736.7 Adult Malpighian Tubules no informative data Adult Fat Body    64.3 Adult Salivary Gland    969.9 Adult Heart    67.25 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    261 Adult Ovary    501.4 Adult Testis    245 Adult Male Accessory Gland    622.3 Adult Carcass    404.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    518.9   NA  Eye    467.8   NA  Brain    248.7   874.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    144.8   NA  Crop    1195.3   71.6  Midgut    48   902.7  Hindgut    736.7   16.4  Malpighian Tubules    no informative data   172.7  Fat Body    64.3   896  Salivary Gland    969.9   NA  Heart    67.25   1569.625  Trachea    NA   NA  VirginFemale Spermatheca    183.1   NA  InseminatedFemale Spermatheca    261   NA  Ovary    501.4   NA  Testis    245   NA  Male Accessory Gland    622.3   605.325  Carcass    404.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010238 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12369-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Lac Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with LacBG01462) Lack11012b lethal (with Lack11012b) LacBG01462 lethal | embryonic stage LacBG01462 lethal | embryonic stage (with Df(2R)BSC3) LacBG01462 lethal | embryonic stage (with Df(2R)CB21) LacBG01462 lethal | pupal stage, with Scer\GAL4pnr-MD237 LacGD12649 lethal | recessive Lack11012b Phenotype manifest in Allele dorsal group branch precursor Lac2 LacBG01462 dorsal trunk primordium Lac2 LacBG01462 embryonic/larval dorsal trunk Lack11012b embryonic/larval tracheal system Lack11012b embryonic/larval transverse connective Lack11012b lateral group branch precursor Lac2 LacBG01462 presumptive embryonic/larval tracheal system Lac2 LacBG01462 presumptive embryonic salivary gland Lac2 LacBG01462 tracheocyte | embryonic stage Lac2 LacBG01462
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of Lac Class Mutagen Stocks Known lesion LacBG01462 P-element activity 2 -- Lacc06354 piggyBac transposase 1 -- Lacc06355 piggyBac transposase 1 -- Lacd00461 P-element activity 1 -- Lace02616 piggyBac transposase 1 -- LacG00044 P-element activity 1 Yes Lack11012b loss of function allele P-element activity 1 -- Lac2 P-element activity 0 Yes LacCPTI002408 piggyBac transposase 0 Yes LacCPTI002601 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lac Class Mutagen Stocks Known lesion LacGD12649 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LacHM05151 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LacKK107469 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LacScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)achi4 (Ayyar et al., 2003) Df(2R)BSC3 (Llimargas et al., 2004) Df(2R)BSC305 (Christensen and Cook, 2007.5.8) Df(2R)BSC409 (Christensen et al., 2008.4.15) Df(2R)BSC829 (Christensen et al., 2009.7.22) Df(2R)BSC859 (Christensen et al., 2009.7.22) Df(2R)CB21 (Llimargas et al., 2004) Df(2R)CX1 (Beitel and Krasnow, 2000)
Not disrupted in	Df(2R)achi2 (Ayyar et al., 2003) Df(2R)achi3 (Ayyar et al., 2003) Df(2R)robl-b (Bowman, 2000.3.30)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12649} NA P{KK107469} NA P{TRiP.HM05151} NA P{UAS-Lac.L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}LacBG01462 NA P{PTT-un1}LacG00044 NA PBac{544.SVS-1}LacCPTI002408 NA PBac{769.FSVS-1}LacCPTI002601 NA PBac{PB}Lacc06354 NA PBac{PB}Lacc06355 NA PBac{RB}Lace02616 NA insertion of mobile activating element P{XP}Lacd00461 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
homophilic cell adhesion inferred from direct assay (Llimargas et al., 2004) maintenance of epithelial integrity, open tracheal system inferred from mutant phenotype (Llimargas et al., 2004) morphogenesis of embryonic epithelium inferred from mutant phenotype (Pilot et al., 2006) open tracheal system development inferred from expression pattern AND inferred from mutant phenotype (Llimargas et al., 2004) inferred from mutant phenotype (Beitel and Krasnow, 2000, Pilot et al., 2006) regulation of tube size, open tracheal system inferred from mutant phenotype (Beitel and Krasnow, 2000, Llimargas et al., 2004)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010) septate junction inferred from direct assay (Llimargas et al., 2004)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axonogenesis inferred from sequence or structural similarity with UniProtKB:Q26474 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
extrinsic to membrane non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lac allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62140 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010238 DroID - A comprehensive database of gene and protein interactions. • FBgn0010238 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36363
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12514 Dere\GG20306 Dgri\GH21969 Dmoj\GI19672 Dper\GL17135 Dpse\GA11586 Dsec\GM21394 Dsim\GD10890 Dvir\GJ15038 Dwil\GK22188 Dyak\GE12466
Curated drosophilid orthologs	Dpse\GA11586
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009295-PA Aedes aegypti (mosquito) AGAP007500-PA Anopheles gambiae (mosquito) XP_397471.3 Apis mellifera (honey bee) XP_001945161.1 Acyrthosiphon pisum (pea aphid) 219652 Branchiostoma floridae (lancelet) BGIBMGA011387-PA Bombyx mori (silk worm) CPIJ008616 Culex pipens (mosquito) ENSCPOP00000018991 Cavia porcellus (guinea pig) 150588 Capitella spl (polychaete worm) 212574 Daphnia pulex (daphnia) ENSECAP00000011697 Equus caballus (horse) ENSGALP00000018497 Gallus gallus (chicken) ENSGALP00000024292 Gallus gallus (chicken) ENSP00000328455 Homo sapiens (human) ENSP00000350364 Homo sapiens (human) ISCW003384-PA Ixodes scapularis (deer tick) ENSMODP00000000573 Monodelphis domestica (gray opossum) ENSMMUP00000022783 Macaca mulatta (rhesus monkey) ENSMUSP00000073664 Mus musculus (house mouse) XP_001604968.1 Nasonia vitripennis (wasp) ENSORLP00000018854 Oryzias latipes (japanese killifish) PHUM005217-PA Pediculus humanus (human body louse) ENSPPYP00000001443 Pongo pygmaeus (orangutan) ENSPPYP00000015122 Pongo pygmaeus (orangutan) ENSPTRP00000001490 Pan troglodytes (chimpanzee) ENSPTRP00000026294 Pan troglodytes (chimpanzee) ENSRNOP00000040165 Rattus norvegicus (norway rat) ENSRNOP00000042811 Rattus norvegicus (norway rat) XP_001182148.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001814833.1 Tribolium castaneum (red flour beetle) ENSTNIP00000002393 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000013408 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000006157 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000008350 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14945 NV50298 NV18228 NV16431 LH16804 ISCW003384 FBgn0241979 FBgn0230209 FBgn0224173 FBgn0214262 FBgn0210406 FBgn0205008 FBgn0202237 FBgn0182653 FBgn0046919 FBgn0176275 FBgn0165859 JGI_V11_212574 FBgn0071637 FBgn0012690 FBgn0159367 FBgn0154739 FBgn0145617 FBgn0142409 FBgn0000071 FBgn0129430 FBgn0125599 FBgn0112497 FBgn0105929 FBgn0094206 FBgn0089551 CPIJ011897 CPIJ008616 BGIBMGA011387 ACYPI008756 ACYPI007274 ACYPI004806 ACYPI000596 GB18710 AGAP007500 AGAP004108 AAEL015529 AAEL009295 AAEL003209 PHUM287200 GLEAN_15310
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	14577 w1118; P{GT1}LacBG01462/CyO 28940 y1 v1; P{TRiP.HM05151}attP2 6833 w1118; P{PTT-un1}LacG00044/CyO 11010 y1 w67c23; Lack11012b, P{lacW}k11012a/CyO
Harvard	- P{XP}Lacd00461 - PBac{PB}Lacc06354 - PBac{PB}Lacc06355 - PBac{RB}Lace02616
Kyoto	114392 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{GT1}LacBG01462 /CyO y+
VDRC	v107450 P{KK107469}VIE-260B v35524 w1118; P{GD12649}v35524
Genomic Clones ( 2 )
	BACR24H09 BACR37P06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 199 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33460 RH65858
Other clones	DPiM_LD33460 FI09235
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD02495 LD05969 LD11855 LD18456 LD20152 LD20288 LD20834 LD46937 LP08592 RE02891 RE05386 RE05945 RE06668 RE07677 RE09776 RE17232 RE17815 RE18173 RE18695 RE19445 RE19738 RE22340 RE24071 RE24118 RE25228 RE25626 RE25949 RE26042 RE26426 RE27020 RE27081 RE28988 RE28993 RE30789 RE31374 RE33145 RE33225 RE33268 RE33359 RE33681 RE35278 RE36008 RE36119 RE42412 RE43359 RE43808 RE44803 RE46220 RE46340 RE48228 RE48291 RE48707 RE49167 RE49279 RE49311 RE50322 RE50607 RE51179 RE51211 RE51779 RE51876 RE52248 RE57576 RE61262 RE61263 RE63449 RE64318 RE67608 RE67623 RE70257 RE72773 RE73183 RE73216 RE73792 RH10029 RH31606 RH33862 RH37636 RH38227 RH39783 RH42858 RH42864 RH47521 RH47528 RH56407 RH57527 RH63872 RH70152 RH71823 SD14819 SD21239
Other clones	15426 17330 19478 31214 33916 38165 43780 55335 57604 58562 62678 63041 70873 77268 80786 98163 99603 101233 159929 177455 179602 274496 CK01.10A.F11 CK01.11A.H5 CK01.11B.G2 CK01.18D.F1 CK01.57D.A10 CK01.80C.D2 CK01.80C.F3 CK01.80C.G3 CK01.81D.B10 CK01.82A.A6 CK01.87D.A8 CK01.89A.H4 CK01.97C.G7 CK01.107B.B4 CK01.141C.E7 EK045935 EK049456 EK062322 EK062326 EK062345 EK064429 EK064735 EK069336 EK070062 EK071702 EK075528 EK108809 EK117920 EK131418 EK146612 EK163126 EK166239 EK174043 EK180948 EK182219 EK190116 EK210637 EK221246 EK222310 EK228445 EK229206 EK262732 EK282922 EK284458 ESG013a.E21.1_G06 ESG0112a.B21.1_C03 FGM002E08 FGM304F11 RP001007679 RP001008723 RP001009911 RP001010877 RP001011770 RP001012252 RP001013601 RP001014311 RP001016993 RP001017072 RP001017840 RP001019700 RP001020073 RP001021216 RP001021331 RP001022148 RP001024803 RP001024939 RP001025215 RP001029853 RP001030776 RP001030952 RP001034010 RP001034060 RP001036662 RP001039342 RP001040221 RP001043583 RP001045473 RP001047156 RP001050754 RP001052700 RP001053050 RP001056554
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010238 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36363
Antibody Information
	polyclonal (Strigini et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: bulb l(2)k11012 (Beitel and Krasnow, 2000)
Source for database merge of	Source for merge of: Lac bulb (Llimargas et al., 2004)
Additional comments
Other Comments
	Embryos injected with dsRNA made from templates generated with primers directed against this gene show late epithelial embryonic defect - these embryos die following profound defects in the development of the tracheal epithelial tubes. (Pilot et al., 2006) Lac behaves as a homophilic cell adhesion molecule required to provide epithelial integrity to the tracheal tubes and to control tubular epithelium length. (Llimargas et al., 2004) Area matching Drosophila Lachesin gene, Acc. No. L13255. (Davies, 2001.3.15) Mutation in Lac alters tracheal tube size in embryos without affecting other aspects of tracheal development including primary branch budding and outgrowth or branch fusion. (Beitel and Krasnow, 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078989 NM_165906 RefSeq (Proteins) • NP_523713 NP_725173 DDBJ / EMBL / GenBank • AA979172 AAC37184 AAF58506 AAK93253 AAM68689 AAO24932 AW943188 AX093894 AY051829 BH901112 BI625438 BT003177 CZ470624 CZ470625 CZ471615 CZ480398 L13255 Entrez Gene - A searchable database of RefSeq genes. • 36363 UniProtKB/Swiss-Prot • Q24372
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62140 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010238 DroID - A comprehensive database of gene and protein interactions. • FBgn0010238 DRSC - Results from RNAi screens. • FBgn0010238 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010238 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12369-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010238 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36363 InParanoid A subset of ortholog calls from InParanoid. • AAEL009295-PA Aedes aegypti (mosquito) AGAP007500-PA Anopheles gambiae (mosquito) XP_397471.3 Apis mellifera (honey bee) XP_001945161.1 Acyrthosiphon pisum (pea aphid) 219652 Branchiostoma floridae (lancelet) BGIBMGA011387-PA Bombyx mori (silk worm) CPIJ008616 Culex pipens (mosquito) ENSCPOP00000018991 Cavia porcellus (guinea pig) 150588 Capitella spl (polychaete worm) 212574 Daphnia pulex (daphnia) ENSECAP00000011697 Equus caballus (horse) ENSGALP00000018497 Gallus gallus (chicken) ENSGALP00000024292 Gallus gallus (chicken) ENSP00000328455 Homo sapiens (human) ENSP00000350364 Homo sapiens (human) ISCW003384-PA Ixodes scapularis (deer tick) ENSMODP00000000573 Monodelphis domestica (gray opossum) ENSMMUP00000022783 Macaca mulatta (rhesus monkey) ENSMUSP00000073664 Mus musculus (house mouse) XP_001604968.1 Nasonia vitripennis (wasp) ENSORLP00000018854 Oryzias latipes (japanese killifish) PHUM005217-PA Pediculus humanus (human body louse) ENSPPYP00000001443 Pongo pygmaeus (orangutan) ENSPPYP00000015122 Pongo pygmaeus (orangutan) ENSPTRP00000001490 Pan troglodytes (chimpanzee) ENSPTRP00000026294 Pan troglodytes (chimpanzee) ENSRNOP00000040165 Rattus norvegicus (norway rat) ENSRNOP00000042811 Rattus norvegicus (norway rat) XP_001182148.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001814833.1 Tribolium castaneum (red flour beetle) ENSTNIP00000002393 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000013408 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000006157 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000008350 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/lachesin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36363 modMine - Data generated by the modENCODE project. • FBgn0010238 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14945 NV50298 NV18228 NV16431 LH16804 ISCW003384 FBgn0241979 FBgn0230209 FBgn0224173 FBgn0214262 FBgn0210406 FBgn0205008 FBgn0202237 FBgn0182653 FBgn0046919 FBgn0176275 FBgn0165859 JGI_V11_212574 FBgn0071637 FBgn0012690 FBgn0159367 FBgn0154739 FBgn0145617 FBgn0142409 FBgn0000071 FBgn0129430 FBgn0125599 FBgn0112497 FBgn0105929 FBgn0094206 FBgn0089551 CPIJ011897 CPIJ008616 BGIBMGA011387 ACYPI008756 ACYPI007274 ACYPI004806 ACYPI000596 GB18710 AGAP007500 AGAP004108 AAEL015529 AAEL009295 AAEL003209 PHUM287200 GLEAN_15310
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	bulb (Behr et al., 2003, Tonning et al., 2005) CG12369 (Keleman et al., 2009.8.5, Perkins et al., 2009, Khanna et al., 2010) CT24921 (Hynes and Zhao, 2000) l(2)k11012 (Bowman, 2000.3.30, Spradling et al., 1999, ) l(2)k11012b (Beitel and Krasnow, 2000) Lac (Furuse and Tsukita, 2006, Pilot et al., 2006, Christensen and Cook, 2007.5.8, Strigini et al., 2006, Christensen et al., 2008.4.15, Kaltenbach et al., 2007, Yi et al., 2008, Araujo et al., 2007, Jin et al., 2009, Christensen et al., 2009.7.22, Christensen et al., 2009.7.22, Laprise et al., 2010, Cherbas et al., 2011) lac (Wu and Beitel, 2004, Wu et al., 2007, Stork et al., 2009)
Name Synonym	bulbous   lachesin (Morin et al., 2001, Karlstrom, 1993.3.25, Stork et al., 2009) Lachesin (Pilot et al., 2006, Stork et al., 2008, Strigini et al., 2006, Wu et al., 2007, Kaltenbach et al., 2007, Yi et al., 2008, Araujo et al., 2007, Laprise et al., 2010, Khanna et al., 2010) lachesin bulbous (Wu and Beitel, 2004)
Secondary FlyBase IDs
	FBgn0021933
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Laprise et al., 2010, Curr. Biol. 20(1): 55--61 Epithelial Polarity Proteins Regulate Drosophila Tracheal Tube Size in Parallel to the Luminal Matrix Pathway. [FBrf0209969] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...