FB2025_02 , released April 17, 2025
Gene: Dmel\Lac
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General Information
Symbol
Dmel\Lac
Species
D. melanogaster
Name
Lachesin
Annotation Symbol
CG12369
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010238
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Lachesin (Lac) encodes a cell surface protein that belongs to the Ig superfamily. It is required for the proper ultrastructural organisation of septate junctions. Lac is required for tracheal system morphogenesis and for muscle contractions associated with peristalsis. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)k11012, bulb

Key Links
Genomic Location
Cytogenetic map
49A6-49A7
Sequence location
Recombination map
2-67
RefSeq locus
NT_033778 REGION:12453190..12465630
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein homodimerization activity
inferred from direct assay
(Strigini et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in cell adhesion involved in heart morphogenesis
inferred from mutant phenotype
(Yi et al., 2008)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from direct assay
(Llimargas et al., 2004)
involved_in maintenance of epithelial integrity, open tracheal system
inferred from mutant phenotype
(Llimargas et al., 2004)
involved_in morphogenesis of embryonic epithelium
inferred from mutant phenotype
(Pilot et al., 2006)
involved_in open tracheal system development
inferred from expression pattern
(Llimargas et al., 2004)
inferred from mutant phenotype
(Pilot et al., 2006, Llimargas et al., 2004, Beitel and Krasnow, 2000)
involved_in regulation of tube size, open tracheal system
inferred from mutant phenotype
(Llimargas et al., 2004, Beitel and Krasnow, 2000)
involved_in septate junction assembly
inferred from mutant phenotype
(Strigini et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009)
located_in septate junction
inferred from direct assay
(Llimargas et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000456776
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Lachesin (Lac) encodes a cell surface protein that belongs to the Ig superfamily. It is required for the proper ultrastructural organisation of septate junctions. Lac is required for tracheal system morphogenesis and for muscle contractions associated with peristalsis. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
LACHESIN SUBFAMILY OF WIRINS -
Wirins are members of a widely distributed family of two- and three-Ig domain molecules that mediate axonal guidance, synapse targeting, and other neuronal wiring-related functions. The Lachesin subfamily is a relatively small Wirin subfamily that expanded specifically in lophotrochozoans, but comprises a single member in D. melanogaster. (Adapted from FBrf0245249.)
Protein Function (UniProtKB)
Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. Functions as a homophilic cell-adhesion molecule. May play a role in early neuronal differentiation and axon outgrowth.
(UniProt, Q24372)
Summary (Interactive Fly)

immunoglobulin domain cell adhesion molecule required for the proper morphogenesis of the tracheal system

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Lac for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24372)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lac-RA
FBtr0087933
NM_078989
2156
359
Additional Transcript Data and Comments
Reported size (kB)

2.1 (longest cDNA)

(Karlstrom et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Lac-PA
FBpp0087044
39.9
359
5.09
Q24372
NP_523713
AAF58506
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

359 (aa)

(Karlstrom et al., 1993)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lac using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.52

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
clypeo-labral anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
hypopharynx anlage in statu nascendi
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
clypeo-labral anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
hypopharynx anlage
(Fisher et al., 2012)
lateral head epidermis
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hypopharynx inclusive primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
hypopharynx proper primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 11 -- 15
presumptive embryonic/larval nervous system | restricted
(Strigini et al., 2006)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval tracheal dorsal trunk
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
embryonic/larval visceral tracheal branch
(Fisher et al., 2012)
labral segment
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 15
nerve root
(Strigini et al., 2006)
nerve
(Strigini et al., 2006)
Additional Descriptive Data

Lac transcript starts being expressed in a small cluster of cells per hemisegment at embryonic stage 11. At embryonic stage 15, expression is detected in 3 small clusters of cells per hemisegment, in the nerves and nerve roots.

(Strigini et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009)
located_in septate junction
inferred from direct assay
(Llimargas et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lac in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lac
Transgenic constructs containing regulatory region of Lac
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (163)
Hsap\NEGR1
9 of 14
Yes
Yes
1  
Hsap\IGLON5
7 of 14
No
No
Hsap\LSAMP
7 of 14
No
No
Hsap\NTM
7 of 14
No
No
Hsap\OPCML
7 of 14
No
No
Hsap\IGSF9B
3 of 14
No
No
Hsap\NCAM1
3 of 14
No
No
4  
Hsap\NCAM2
3 of 14
No
No
Hsap\CHL1
2 of 14
No
No
Hsap\DSCAM
2 of 14
No
No
3  
Hsap\IGSF5
2 of 14
No
Yes
Hsap\IGSF9
2 of 14
No
No
2  
Hsap\KIRREL1
2 of 14
No
No
Hsap\KIRREL2
2 of 14
No
No
Hsap\KIRREL3
2 of 14
No
No
Hsap\L1CAM
2 of 14
No
No
11  
Hsap\LRIT3
2 of 14
No
Yes
Hsap\SDK1
2 of 14
No
No
Hsap\SDK2
2 of 14
No
No
1  
Hsap\ACAN
1 of 14
No
No
Hsap\ADAMTSL3
1 of 14
No
No
Hsap\BOC
1 of 14
No
No
2  
Hsap\BSG
1 of 14
No
No
Hsap\BTN1A1
1 of 14
No
Yes
Hsap\BTN2A1
1 of 14
No
Yes
Hsap\BTN2A2
1 of 14
No
Yes
Hsap\BTN2A3P
1 of 14
No
Yes
Hsap\BTN3A1
1 of 14
No
Yes
Hsap\BTN3A2
1 of 14
No
Yes
Hsap\BTN3A3
1 of 14
No
Yes
Hsap\BTNL2
1 of 14
No
Yes
Hsap\BTNL3
1 of 14
No
Yes
Hsap\BTNL8
1 of 14
No
Yes
Hsap\CADM1
1 of 14
No
No
Hsap\CADM2
1 of 14
No
No
Hsap\CADM3
1 of 14
No
No
Hsap\CADM4
1 of 14
No
No
Hsap\CD22
1 of 14
No
No
Hsap\CD33
1 of 14
No
No
1  
Hsap\CD48
1 of 14
No
Yes
Hsap\CD58
1 of 14
No
Yes
Hsap\CD80
1 of 14
No
No
Hsap\CD84
1 of 14
No
Yes
Hsap\CD86
1 of 14
No
No
Hsap\CD244
1 of 14
No
Yes
Hsap\CD274
1 of 14
No
Yes
Hsap\CD276
1 of 14
No
Yes
Hsap\CDON
1 of 14
No
No
Hsap\CEACAM1
1 of 14
No
No
Hsap\CEACAM5
1 of 14
No
No
Hsap\CEACAM6
1 of 14
No
No
Hsap\CEACAM8
1 of 14
No
No
Hsap\CEACAM20
1 of 14
No
Yes
Hsap\CEACAM21
1 of 14
No
Yes
Hsap\CLMP
1 of 14
No
Yes
Hsap\CNTN1
1 of 14
No
No
Hsap\CNTN4
1 of 14
No
No
Hsap\CNTN5
1 of 14
No
No
Hsap\CNTN6
1 of 14
No
No
Hsap\CXADR
1 of 14
No
Yes
Hsap\DCC
1 of 14
No
No
4  
Hsap\DSCAML1
1 of 14
No
No
2  
Hsap\ESAM
1 of 14
No
Yes
Hsap\F11R
1 of 14
No
Yes
Hsap\FCGR1A
1 of 14
No
Yes
Hsap\FCRL1
1 of 14
No
Yes
Hsap\FCRL2
1 of 14
No
Yes
Hsap\FCRL3
1 of 14
No
Yes
Hsap\FCRL4
1 of 14
No
Yes
Hsap\FCRL5
1 of 14
No
Yes
Hsap\FCRL6
1 of 14
No
Yes
Hsap\FCRLA
1 of 14
No
Yes
Hsap\FCRLB
1 of 14
No
Yes
Hsap\FGFRL1
1 of 14
No
No
Hsap\FLT4
1 of 14
No
No
Hsap\FSTL4
1 of 14
No
Yes
Hsap\FSTL5
1 of 14
No
Yes
Hsap\GPA33
1 of 14
No
Yes
Hsap\HAPLN3
1 of 14
No
Yes
Hsap\HAVCR2
1 of 14
No
Yes
Hsap\HEPACAM2
1 of 14
No
Yes
Hsap\HEPACAM
1 of 14
No
Yes
Hsap\HHLA2
1 of 14
No
Yes
Hsap\HMCN1
1 of 14
No
No
Hsap\HMCN2
1 of 14
No
No
Hsap\HSPG2
1 of 14
No
No
Hsap\HTRA1
1 of 14
No
No
Hsap\HTRA3
1 of 14
No
No
Hsap\HTRA4
1 of 14
No
No
Hsap\ICOSLG
1 of 14
No
No
Hsap\IGDCC3
1 of 14
No
No
Hsap\IGDCC4
1 of 14
No
No
Hsap\IGFBP7
1 of 14
No
Yes
Hsap\IGFBPL1
1 of 14
No
Yes
Hsap\IGSF10
1 of 14
No
No
Hsap\IGSF11
1 of 14
No
Yes
Hsap\IGSF23
1 of 14
No
Yes
Hsap\JAM3
1 of 14
No
Yes
Hsap\KAZALD1
1 of 14
No
Yes
Hsap\LRIG1
1 of 14
No
No
Hsap\LRIG2
1 of 14
No
No
Hsap\LRIG3
1 of 14
No
No
Hsap\LRIT1
1 of 14
No
No
Hsap\LY9
1 of 14
No
Yes
Hsap\MAG
1 of 14
No
No
Hsap\MCAM
1 of 14
No
Yes
Hsap\MDGA1
1 of 14
No
No
Hsap\MUSK
1 of 14
No
No
1  
Hsap\MXRA5
1 of 14
No
No
Hsap\MXRA8
1 of 14
No
Yes
Hsap\MYLK
1 of 14
No
No
Hsap\MYOT
1 of 14
No
No
Hsap\NCR3LG1
1 of 14
No
Yes
Hsap\NECTIN1
1 of 14
No
No
Hsap\NECTIN2
1 of 14
No
No
Hsap\NECTIN3
1 of 14
No
No
Hsap\NECTIN4
1 of 14
No
No
Hsap\NEO1
1 of 14
No
No
Hsap\NFASC
1 of 14
No
No
Hsap\NRCAM
1 of 14
No
No
Hsap\OBSCN
1 of 14
No
No
Hsap\OBSL1
1 of 14
No
No
Hsap\PALLD
1 of 14
No
No
Hsap\PAPLN
1 of 14
No
No
Hsap\PDCD1LG2
1 of 14
No
Yes
Hsap\PECAM1
1 of 14
No
Yes
Hsap\PRTG
1 of 14
No
No
Hsap\PSG4
1 of 14
No
Yes
Hsap\PTK7
1 of 14
No
No
1  
Hsap\PTPRD
1 of 14
No
No
Hsap\PTPRF
1 of 14
No
No
2  
Hsap\PTPRS
1 of 14
No
No
Hsap\PVR
1 of 14
No
No
1  
Hsap\PXDN
1 of 14
No
No
3  
Hsap\PXDNL
1 of 14
No
No
1  
Hsap\ROBO1
1 of 14
No
No
4  
Hsap\ROBO2
1 of 14
No
No
Hsap\ROBO3
1 of 14
No
No
Hsap\SIGLEC1
1 of 14
No
No
Hsap\SIGLEC5
1 of 14
No
No
Hsap\SIGLEC6
1 of 14
No
No
Hsap\SIGLEC7
1 of 14
No
No
Hsap\SIGLEC8
1 of 14
No
No
Hsap\SIGLEC10
1 of 14
No
No
Hsap\SIGLEC11
1 of 14
No
No
Hsap\SIGLEC12
1 of 14
No
No
Hsap\SIGLEC14
1 of 14
No
No
Hsap\SIGLEC15
1 of 14
No
Yes
Hsap\SIGLEC16
1 of 14
No
No
Hsap\SPEGNB
1 of 14
No
No
Hsap\TAPBPL
1 of 14
No
Yes
1  
Hsap\TMIGD1
1 of 14
No
No
Hsap\TRIO
1 of 14
No
No
1  
Hsap\TTN
1 of 14
No
No
Hsap\TYRO3
1 of 14
No
Yes
Hsap\USH2A
1 of 14
No
No
Hsap\VCAM1
1 of 14
No
Yes
Hsap\VSIG1
1 of 14
No
Yes
Hsap\VSIG2
1 of 14
No
Yes
Hsap\VSIG4
1 of 14
No
Yes
Hsap\VSIG8
1 of 14
No
Yes
Hsap\VSIG10
1 of 14
No
Yes
Hsap\VTCN1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (74)
Rnor\Iglon5
6 of 14
Yes
No
Rnor\Lsamp
6 of 14
Yes
No
Rnor\Negr1
6 of 14
Yes
No
Rnor\Opcml
6 of 14
Yes
No
Rnor\Ntm
5 of 14
No
No
Rnor\Igsf9b
4 of 14
No
No
Rnor\Ncam1
3 of 14
No
No
Rnor\Dscam
2 of 14
No
No
Rnor\Igsf9
2 of 14
No
No
Rnor\Kirrel2
2 of 14
No
No
Rnor\Kirrel3
2 of 14
No
No
Rnor\Ncam2
2 of 14
No
No
Rnor\Sdk2
2 of 14
No
No
Rnor\Vsig10
2 of 14
No
Yes
Rnor\Boc
1 of 14
No
No
Rnor\Bsg
1 of 14
No
No
Rnor\Btnl2
1 of 14
No
Yes
Rnor\Btnl3
1 of 14
No
Yes
Rnor\Btnl5
1 of 14
No
Yes
Rnor\Btnl7
1 of 14
No
No
Rnor\Btnl8
1 of 14
No
Yes
Rnor\Btnl9
1 of 14
No
Yes
Rnor\Btnl10
1 of 14
No
No
Rnor\Cadm1
1 of 14
No
No
Rnor\Cadm2
1 of 14
No
No
Rnor\Cadm3
1 of 14
No
No
Rnor\Cadm4
1 of 14
No
No
Rnor\Cd48
1 of 14
No
Yes
Rnor\Cd84
1 of 14
No
Yes
Rnor\Cd274
1 of 14
No
Yes
Rnor\Cd276
1 of 14
No
Yes
Rnor\Cgm4
1 of 14
No
No
Rnor\Chl1
1 of 14
No
No
Rnor\Clmp
1 of 14
No
Yes
Rnor\Cntn5
1 of 14
No
No
Rnor\Cntn6
1 of 14
No
No
Rnor\Cxadr
1 of 14
No
Yes
Rnor\Dcc
1 of 14
No
No
Rnor\Dscaml1
1 of 14
No
No
Rnor\F11r
1 of 14
No
Yes
Rnor\Fcrl5
1 of 14
No
Yes
Rnor\Fgfrl1
1 of 14
No
No
Rnor\Gpa33
1 of 14
No
Yes
Rnor\Hepacam
1 of 14
No
Yes
Rnor\Hmcn1
1 of 14
No
No
Rnor\Igsf5
1 of 14
No
Yes
Rnor\Igsf10
1 of 14
No
No
Rnor\Jam3
1 of 14
No
Yes
Rnor\Kirrel1
1 of 14
No
No
Rnor\Lag3
1 of 14
No
Yes
Rnor\Lrig1
1 of 14
No
No
Rnor\Lrig2
1 of 14
No
No
Rnor\Lrig3
1 of 14
No
No
Rnor\Lrit1
1 of 14
No
No
Rnor\Mag
1 of 14
No
Yes
Rnor\Musk
1 of 14
No
No
Rnor\Nectin3
1 of 14
No
No
Rnor\Neo1
1 of 14
No
No
Rnor\Obscn
1 of 14
No
No
Rnor\Prtg
1 of 14
No
Yes
Rnor\Psg16
1 of 14
No
No
Rnor\Pvr
1 of 14
No
Yes
Rnor\Pxdn
1 of 14
No
No
Rnor\RGD1624210
1 of 14
No
No
Rnor\Robo1
1 of 14
No
No
Rnor\Siglec10
1 of 14
No
No
Rnor\Skint1
1 of 14
No
Yes
Rnor\Skint8
1 of 14
No
Yes
Rnor\Slamf9
1 of 14
No
Yes
Rnor\Tmigd1
1 of 14
No
No
Rnor\Vcam1
1 of 14
No
Yes
Rnor\Vsig2
1 of 14
No
Yes
Rnor\Vsig4
1 of 14
No
Yes
Rnor\Vsig10l
1 of 14
No
Yes
Mus musculus (laboratory mouse) (73)
Mmus\Iglon5
6 of 14
Yes
No
Mmus\Negr1
6 of 14
Yes
No
Mmus\Ntm
6 of 14
Yes
No
Mmus\Opcml
6 of 14
Yes
No
Mmus\Lsamp
5 of 14
No
No
Mmus\Igsf9b
4 of 14
No
No
Mmus\Ncam1
3 of 14
No
No
Mmus\Dscam
2 of 14
No
No
1  
Mmus\Igsf9
2 of 14
No
No
Mmus\Kirrel2
2 of 14
No
No
1  
Mmus\Kirrel3
2 of 14
No
No
1  
Mmus\Ncam2
2 of 14
No
No
Mmus\Sdk1
2 of 14
No
No
Mmus\Sdk2
2 of 14
No
No
Mmus\Bsg
1 of 14
No
No
1  
Mmus\Btn1a1
1 of 14
No
No
Mmus\Btnl2
1 of 14
No
Yes
Mmus\Btnl4
1 of 14
No
Yes
Mmus\Btnl6
1 of 14
No
Yes
Mmus\Btnl9
1 of 14
No
Yes
Mmus\Btnl10
1 of 14
No
No
Mmus\Cadm1
1 of 14
No
No
Mmus\Cadm2
1 of 14
No
No
Mmus\Cadm3
1 of 14
No
No
Mmus\Cadm4
1 of 14
No
No
Mmus\Cd48
1 of 14
No
Yes
Mmus\Cd80
1 of 14
No
Yes
Mmus\Cd84
1 of 14
No
Yes
Mmus\Cd86
1 of 14
No
Yes
Mmus\Cd244a
1 of 14
No
Yes
Mmus\Clmp
1 of 14
No
Yes
Mmus\Cntn1
1 of 14
No
No
Mmus\Cntn4
1 of 14
No
No
Mmus\Cntn5
1 of 14
No
No
Mmus\Dcc
1 of 14
No
No
Mmus\Dscaml1
1 of 14
No
No
Mmus\F11r
1 of 14
No
Yes
Mmus\Fgfrl1
1 of 14
No
No
Mmus\Gpa33
1 of 14
No
Yes
Mmus\Hepacam
1 of 14
No
Yes
Mmus\Hmcn1
1 of 14
No
No
Mmus\Hmcn2
1 of 14
No
No
Mmus\Hspg2
1 of 14
No
No
Mmus\Igsf5
1 of 14
No
Yes
Mmus\Jam3
1 of 14
No
Yes
Mmus\Kirrel
1 of 14
No
No
1  
Mmus\Lag3
1 of 14
No
Yes
Mmus\Lrig1
1 of 14
No
No
Mmus\Lrig2
1 of 14
No
No
Mmus\Lrig3
1 of 14
No
No
Mmus\Lrit1
1 of 14
No
No
Mmus\Lrit3
1 of 14
No
No
Mmus\Ly9
1 of 14
No
Yes
Mmus\Mag
1 of 14
No
Yes
Mmus\Musk
1 of 14
No
No
Mmus\Nectin3
1 of 14
No
No
Mmus\Neo1
1 of 14
No
No
Mmus\Obscn
1 of 14
No
No
Mmus\Palld
1 of 14
No
Yes
Mmus\Papln
1 of 14
No
No
Mmus\Ptprq
1 of 14
No
No
Mmus\Pxdn
1 of 14
No
No
Mmus\Robo1
1 of 14
No
No
Mmus\Siglecf
1 of 14
No
No
Mmus\Skint2
1 of 14
No
Yes
Mmus\Skint7
1 of 14
No
Yes
Mmus\Skint8
1 of 14
No
Yes
Mmus\Slamf9
1 of 14
No
Yes
Mmus\Tmigd1
1 of 14
No
No
Mmus\Ttn
1 of 14
No
No
Mmus\Vcam1
1 of 14
No
Yes
Mmus\Vsig4
1 of 14
No
Yes
Mmus\Vsig10
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (86)
Xtro\iglon5
4 of 13
Yes
No
Xtro\negr1
4 of 13
Yes
No
Xtro\lsamp
3 of 13
No
No
Xtro\ntm
3 of 13
No
No
Xtro\opcml
3 of 13
No
No
Xtro\mxra5
2 of 13
No
Yes
Xtro\ncam2
2 of 13
No
No
Xtro\adamtsl1
1 of 13
No
No
Xtro\bcam
1 of 13
No
No
Xtro\btn2a1
1 of 13
No
Yes
Xtro\cadm2
1 of 13
No
No
Xtro\cby1
1 of 13
No
No
Xtro\cd22
1 of 13
No
No
Xtro\cd276
1 of 13
No
Yes
Xtro\ceacam8l
1 of 13
No
No
Xtro\chl1
1 of 13
No
No
Xtro\clmp
1 of 13
No
Yes
Xtro\col20a1
1 of 13
No
No
Xtro\cox20
1 of 13
No
No
Xtro\cxadr
1 of 13
No
Yes
Xtro\dcc
1 of 13
No
No
Xtro\dscam
1 of 13
No
No
Xtro\esam
1 of 13
No
Yes
Xtro\fgfr1op2
1 of 13
No
No
Xtro\fgfr3
1 of 13
No
No
Xtro\hcn2
1 of 13
No
No
Xtro\hepacam2
1 of 13
No
Yes
Xtro\hepacam
1 of 13
No
Yes
Xtro\hmcn1
1 of 13
No
No
Xtro\hmcn2
1 of 13
No
No
Xtro\htra1
1 of 13
No
No
Xtro\htra3
1 of 13
No
No
Xtro\htra4
1 of 13
No
No
Xtro\igdcc3
1 of 13
No
No
Xtro\igsf5
1 of 13
No
Yes
Xtro\igsf9b
1 of 13
No
No
Xtro\igsf9
1 of 13
No
No
Xtro\igsf10
1 of 13
No
No
Xtro\jam2
1 of 13
No
Yes
Xtro\jam3
1 of 13
No
Yes
Xtro\kazald1
1 of 13
No
Yes
Xtro\kirrel1
1 of 13
No
No
Xtro\LOC100488475
1 of 13
No
Yes
Xtro\LOC100492862
1 of 13
No
Yes
Xtro\LOC100496188
1 of 13
No
Yes
Xtro\LOC101731191
1 of 13
No
Yes
Xtro\LOC101732060
1 of 13
No
Yes
Xtro\LOC101732679
1 of 13
No
Yes
Xtro\LOC101733623
1 of 13
No
No
Xtro\LOC101735075
1 of 13
No
No
Xtro\LOC105945166
1 of 13
No
Yes
Xtro\LOC105948415
1 of 13
No
No
Xtro\LOC108648295
1 of 13
No
Yes
Xtro\LOC108648322
1 of 13
No
No
Xtro\LOC116408200
1 of 13
No
Yes
Xtro\LOC116408355
1 of 13
No
Yes
Xtro\lrig1
1 of 13
No
No
Xtro\lrig2
1 of 13
No
No
Xtro\lrig3
1 of 13
No
No
Xtro\mag
1 of 13
No
Yes
Xtro\map3k1
1 of 13
No
Yes
Xtro\mov10
1 of 13
No
No
Xtro\ncam1
1 of 13
No
No
Xtro\nectin1l1
1 of 13
No
Yes
Xtro\nectin1
1 of 13
No
Yes
Xtro\nectin4
1 of 13
No
Yes
Xtro\nptn
1 of 13
No
No
Xtro\nrcam
1 of 13
No
No
Xtro\pecam1
1 of 13
No
Yes
Xtro\pxdn
1 of 13
No
No
Xtro\rgs2
1 of 13
No
Yes
Xtro\rplp0
1 of 13
No
No
Xtro\siglec15
1 of 13
No
Yes
Xtro\slc35g1
1 of 13
No
No
Xtro\spata1
1 of 13
No
Yes
Xtro\tmigd1
1 of 13
No
Yes
Xtro\tyro3
1 of 13
No
Yes
Xtro\u2af2
1 of 13
No
No
Xtro\upk2
1 of 13
No
No
Xtro\vcam1
1 of 13
No
Yes
Xtro\vsig8
1 of 13
No
Yes
Xtro\vstm2b
1 of 13
No
Yes
Xtro\XB5805949
1 of 13
No
Yes
Xtro\XB5960289
1 of 13
No
No
Xtro\XB5991222
1 of 13
No
No
Xtro\XB22063306
1 of 13
No
Yes
Danio rerio (Zebrafish) (198)
Drer\negr1
8 of 14
Yes
No
Drer\opcml
7 of 14
No
No
Drer\iglon5
6 of 14
No
No
Drer\ntm
6 of 14
No
No
Drer\cntn5
2 of 14
No
No
Drer\dscama
2 of 14
No
No
Drer\dscamb
2 of 14
No
No
Drer\hspg2
2 of 14
No
No
Drer\igsf9a
2 of 14
No
No
Drer\igsf9ba
2 of 14
No
No
Drer\igsf9bb
2 of 14
No
No
Drer\kirrel1b
2 of 14
No
No
Drer\ncam1a
2 of 14
No
No
Drer\ncam1b
2 of 14
No
No
Drer\pxdn
2 of 14
No
No
Drer\sdk1a
2 of 14
No
No
Drer\vsig10
2 of 14
No
Yes
Drer\zgc:152904
2 of 14
No
No
Drer\adgrl1.1
1 of 14
No
Yes
Drer\aebp1b
1 of 14
No
No
Drer\cadm1a
1 of 14
No
No
Drer\cadm1b
1 of 14
No
No
Drer\cadm2a
1 of 14
No
No
Drer\cadm2b
1 of 14
No
No
Drer\cadm3
1 of 14
No
No
Drer\cadm4
1 of 14
No
No
Drer\cd4-2.2
1 of 14
No
Yes
Drer\chl1a
1 of 14
No
No
Drer\chl1b
1 of 14
No
No
Drer\cntn1a
1 of 14
No
No
Drer\cntn3a.1
1 of 14
No
No
Drer\cntn3a.2
1 of 14
No
No
Drer\cntn3b
1 of 14
No
No
Drer\cntn4
1 of 14
No
No
Drer\cxadr
1 of 14
No
Yes
Drer\dscaml1
1 of 14
No
No
Drer\f11r.1
1 of 14
No
Yes
Drer\f11r.2
1 of 14
No
No
Drer\fgfrl1b
1 of 14
No
No
Drer\fstl4
1 of 14
No
Yes
Drer\hepacama
1 of 14
No
Yes
Drer\hmcn1
1 of 14
No
No
Drer\hmcn2
1 of 14
No
No
Drer\icam3
1 of 14
No
Yes
Drer\igdcc3
1 of 14
No
No
Drer\igsf5a
1 of 14
No
Yes
Drer\igsf5b
1 of 14
No
Yes
Drer\igsf11
1 of 14
No
Yes
Drer\itgb4
1 of 14
No
No
Drer\kirrel1a
1 of 14
No
No
Drer\kirrel3l
1 of 14
No
No
Drer\kitb
1 of 14
No
No
Drer\LOC569566
1 of 14
No
No
Drer\LOC797394
1 of 14
No
Yes
Drer\LOC100002141
1 of 14
No
Yes
Drer\LOC100003530
1 of 14
No
Yes
Drer\LOC100004104
1 of 14
No
Yes
Drer\LOC100006469
1 of 14
No
Yes
Drer\LOC100006557
1 of 14
No
Yes
Drer\LOC100006764
1 of 14
No
Yes
Drer\LOC100006875
1 of 14
No
Yes
Drer\LOC100007503
1 of 14
No
Yes
Drer\LOC100007935
1 of 14
No
Yes
Drer\LOC100007948
1 of 14
No
Yes
Drer\LOC100148735
1 of 14
No
No
Drer\LOC100151078
1 of 14
No
Yes
Drer\LOC100329818
1 of 14
No
Yes
Drer\LOC100330694
1 of 14
No
Yes
Drer\LOC100331045
1 of 14
No
Yes
Drer\LOC100331974
1 of 14
No
Yes
Drer\LOC100332721
1 of 14
No
No
Drer\LOC100333752
1 of 14
No
Yes
Drer\LOC100333939
1 of 14
No
Yes
Drer\LOC100334619
1 of 14
No
Yes
Drer\LOC100334996
1 of 14
No
Yes
Drer\LOC100535756
1 of 14
No
Yes
Drer\LOC100536572
1 of 14
No
Yes
Drer\LOC100536726
1 of 14
No
Yes
Drer\LOC100538136
1 of 14
No
Yes
Drer\LOC101882696
1 of 14
No
Yes
Drer\LOC101883331
1 of 14
No
Yes
Drer\LOC101883412
1 of 14
No
Yes
Drer\LOC101883645
1 of 14
No
Yes
Drer\LOC101884023
1 of 14
No
Yes
Drer\LOC101884052
1 of 14
No
Yes
Drer\LOC101886679
1 of 14
No
Yes
Drer\LOC101886743
1 of 14
No
Yes
Drer\LOC103908669
1 of 14
No
Yes
Drer\LOC103909439
1 of 14
No
No
Drer\LOC103909535
1 of 14
No
Yes
Drer\LOC103909536
1 of 14
No
Yes
Drer\LOC103909541
1 of 14
No
Yes
Drer\LOC103909548
1 of 14
No
Yes
Drer\LOC103909724
1 of 14
No
Yes
Drer\LOC108181196
1 of 14
No
Yes
Drer\LOC110438256
1 of 14
No
Yes
Drer\lrig2
1 of 14
No
No
Drer\lrit1a
1 of 14
No
No
Drer\lrit3a
1 of 14
No
No
Drer\lrit3b
1 of 14
No
No
Drer\lsamp
1 of 14
No
Yes
Drer\mdga1
1 of 14
No
Yes
Drer\mertka
1 of 14
No
Yes
Drer\ncam2
1 of 14
No
No
Drer\nectin3a
1 of 14
No
No
Drer\nectin3b
1 of 14
No
No
Drer\neo1a
1 of 14
No
No
Drer\neo1b
1 of 14
No
No
Drer\nfasca
1 of 14
No
No
Drer\nphs1
1 of 14
No
No
Drer\nrcama
1 of 14
No
No
Drer\obscnb
1 of 14
No
No
Drer\obsl1b
1 of 14
No
No
Drer\olfml2ba
1 of 14
No
No
Drer\paplna
1 of 14
No
No
Drer\ptk7a
1 of 14
No
No
Drer\robo1
1 of 14
No
No
Drer\robo2
1 of 14
No
No
Drer\robo3
1 of 14
No
No
Drer\robo4
1 of 14
No
No
Drer\sc:d0202
1 of 14
No
Yes
Drer\sc:d217
1 of 14
No
Yes
Drer\si:ch73-22o12.1
1 of 14
No
No
Drer\si:ch73-27e22.1
1 of 14
No
Yes
Drer\si:ch73-27e22.4
1 of 14
No
Yes
Drer\si:ch73-27e22.6
1 of 14
No
Yes
Drer\si:ch73-27e22.7
1 of 14
No
Yes
Drer\si:ch73-44m9.1
1 of 14
No
No
Drer\si:ch73-170d6.3
1 of 14
No
Yes
Drer\si:ch73-208g10.1
1 of 14
No
Yes
Drer\si:ch73-213k20.5
1 of 14
No
Yes
Drer\si:ch73-256j6.2
1 of 14
No
Yes
Drer\si:ch73-256j6.4
1 of 14
No
Yes
Drer\si:ch73-256j6.6
1 of 14
No
Yes
Drer\si:ch73-304f21.1
1 of 14
No
Yes
Drer\si:ch211-1f22.12
1 of 14
No
No
Drer\si:ch211-57n23.4
1 of 14
No
No
Drer\si:ch211-66e2.3
1 of 14
No
Yes
Drer\si:ch211-66e2.5
1 of 14
No
Yes
Drer\si:ch211-74m13.1
1 of 14
No
Yes
Drer\si:ch211-105n15.1
1 of 14
No
Yes
Drer\si:ch211-132g1.3
1 of 14
No
Yes
Drer\si:ch211-132g1.4
1 of 14
No
Yes
Drer\si:ch211-132g1.6
1 of 14
No
Yes
Drer\si:ch211-159i8.4
1 of 14
No
No
Drer\si:ch211-170a17.1
1 of 14
No
No
Drer\si:ch211-209f23.6
1 of 14
No
Yes
Drer\si:ch211-209l18.2
1 of 14
No
Yes
Drer\si:ch211-213a13.1
1 of 14
No
Yes
Drer\si:ch211-222k6.3
1 of 14
No
Yes
Drer\si:ch211-236g6.1
1 of 14
No
Yes
Drer\si:ch211-239m17.1
1 of 14
No
Yes
Drer\si:ch211-274k16.2
1 of 14
No
Yes
Drer\si:ch211-274k16.9
1 of 14
No
Yes
Drer\si:ch1073-214b20.2
1 of 14
No
Yes
Drer\si:dkey-11f4.14
1 of 14
No
Yes
Drer\si:dkey-11f4.16
1 of 14
No
Yes
Drer\si:dkey-11f4.20
1 of 14
No
Yes
Drer\si:dkey-19a16.2
1 of 14
No
Yes
Drer\si:dkey-19a16.4
1 of 14
No
Yes
Drer\si:dkey-19a16.5
1 of 14
No
Yes
Drer\si:dkey-19a16.12
1 of 14
No
Yes
Drer\si:dkey-102c8.2
1 of 14
No
Yes
Drer\si:dkey-102c8.3
1 of 14
No
Yes
Drer\si:dkey-182g1.2
1 of 14
No
Yes
Drer\si:dkey-182g1.3
1 of 14
No
Yes
Drer\si:dkey-182g1.4
1 of 14
No
Yes
Drer\si:dkey-182g1.10
1 of 14
No
Yes
Drer\si:dkey-222f2.7
1 of 14
No
Yes
Drer\si:dkey-250k15.7
1 of 14
No
Yes
Drer\si:dkey-250k15.10
1 of 14
No
Yes
Drer\si:dkey-253d23.3
1 of 14
No
Yes
Drer\si:dkey-253d23.4
1 of 14
No
Yes
Drer\si:rp71-1i20.1
1 of 14
No
Yes
Drer\si:rp71-1i20.2
1 of 14
No
Yes
Drer\si:rp71-36a1.1
1 of 14
No
Yes
Drer\si:rp71-36a1.2
1 of 14
No
Yes
Drer\si:rp71-36a1.3
1 of 14
No
Yes
Drer\si:rp71-36a1.5
1 of 14
No
Yes
Drer\spega
1 of 14
No
No
Drer\tmigd1
1 of 14
No
Yes
Drer\ttn.1
1 of 14
No
No
Drer\ttn.2
1 of 14
No
No
Drer\ush2a
1 of 14
No
No
Drer\vsig8a
1 of 14
No
Yes
Drer\zgc:77784
1 of 14
No
No
Drer\zgc:113293
1 of 14
No
Yes
Drer\zgc:123297
1 of 14
No
Yes
Drer\zgc:162154
1 of 14
No
Yes
Drer\zgc:171490
1 of 14
No
Yes
Drer\zgc:171497
1 of 14
No
Yes
Drer\zgc:171601
1 of 14
No
Yes
Drer\zgc:171686
1 of 14
No
Yes
Drer\zgc:171699
1 of 14
No
Yes
Drer\zgc:171887
1 of 14
No
Yes
Drer\zgc:172133
1 of 14
No
Yes
Drer\zmp:0000000652
1 of 14
No
Yes
Drer\zmp:0000001161
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (28)
Cele\rig-5
5 of 14
Yes
No
Cele\igcm-2
2 of 14
No
No
Cele\rig-3
2 of 14
No
Yes
Cele\rig-4
2 of 14
No
No
Cele\wrk-1
2 of 14
No
No
Cele\zig-8
2 of 14
No
No
Cele\egl-15
1 of 14
No
No
Cele\him-4
1 of 14
No
No
Cele\igcm-1
1 of 14
No
No
Cele\ketn-1
1 of 14
No
No
Cele\madd-4
1 of 14
No
No
Cele\ncam-1
1 of 14
No
No
Cele\ptp-3
1 of 14
No
No
Cele\pxn-1
1 of 14
No
No
Cele\sax-3
1 of 14
No
No
Cele\sax-7
1 of 14
No
No
Cele\sma-10
1 of 14
No
No
Cele\ttn-1
1 of 14
No
No
Cele\unc-40
1 of 14
No
No
Cele\unc-89
1 of 14
No
No
Cele\ver-1
1 of 14
No
No
Cele\zig-1
1 of 14
No
Yes
Cele\zig-2
1 of 14
No
No
Cele\zig-3
1 of 14
No
No
Cele\zig-4
1 of 14
No
No
Cele\zig-7
1 of 14
No
Yes
Cele\zig-10
1 of 14
No
Yes
Cele\zig-11
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (88)
Agam\AgaP_AGAP007500
12 of 12
Yes
Yes
Agam\AgaP_AGAP000863
6 of 12
No
No
Agam\AgaP_AGAP003235
6 of 12
No
No
Agam\AgaP_AGAP004915
6 of 12
No
No
Agam\AgaP_AGAP008778
6 of 12
No
No
Agam\AgaP_AGAP008655
5 of 12
No
No
Agam\AgaP_AGAP008776
5 of 12
No
No
Agam\AgaP_AGAP009964
5 of 12
No
No
Agam\AgaP_AGAP009965
5 of 12
No
No
Agam\AgaP_AGAP010221
5 of 12
No
No
Agam\AgaP_AGAP010222
5 of 12
No
No
Agam\AgaP_AGAP001048
4 of 12
No
No
Agam\AgaP_AGAP004108
4 of 12
No
No
Agam\AgaP_AGAP010422
4 of 12
No
Yes
Agam\AgaP_AGAP001304
3 of 12
No
No
Agam\AgaP_AGAP002325
3 of 12
No
No
Agam\AgaP_AGAP002628
3 of 12
No
No
Agam\AgaP_AGAP011194
3 of 12
No
No
Agam\AgaP_AGAP011195
3 of 12
No
No
Agam\AgaP_AGAP000217
2 of 12
No
No
Agam\AgaP_AGAP000218
2 of 12
No
No
Agam\AgaP_AGAP000659
2 of 12
No
No
Agam\AgaP_AGAP001126
2 of 12
No
No
Agam\AgaP_AGAP001201
2 of 12
No
No
Agam\AgaP_AGAP001239
2 of 12
No
No
Agam\AgaP_AGAP001242
2 of 12
No
No
Agam\AgaP_AGAP002494
2 of 12
No
No
Agam\AgaP_AGAP002707
2 of 12
No
No
Agam\AgaP_AGAP002802
2 of 12
No
No
Agam\AgaP_AGAP005028
2 of 12
No
No
Agam\AgaP_AGAP005068
2 of 12
No
No
Agam\AgaP_AGAP005069
2 of 12
No
No
Agam\AgaP_AGAP005219
2 of 12
No
No
Agam\AgaP_AGAP005794
2 of 12
No
No
Agam\AgaP_AGAP005849
2 of 12
No
No
Agam\AgaP_AGAP006274
2 of 12
No
No
Agam\AgaP_AGAP006350
2 of 12
No
No
Agam\AgaP_AGAP007092
2 of 12
No
No
Agam\AgaP_AGAP007759
2 of 12
No
No
Agam\AgaP_AGAP007928
2 of 12
No
No
Agam\AgaP_AGAP008734
2 of 12
No
No
Agam\AgaP_AGAP008943
2 of 12
No
No
Agam\AgaP_AGAP009183
2 of 12
No
No
Agam\AgaP_AGAP009242
2 of 12
No
No
Agam\AgaP_AGAP009245
2 of 12
No
No
Agam\AgaP_AGAP009247
2 of 12
No
No
Agam\AgaP_AGAP009248
2 of 12
No
No
Agam\AgaP_AGAP009250
2 of 12
No
No
Agam\AgaP_AGAP009253
2 of 12
No
No
Agam\AgaP_AGAP009518
2 of 12
No
No
Agam\AgaP_AGAP010542
2 of 12
No
No
Agam\AgaP_AGAP010884
2 of 12
No
No
Agam\AgaP_AGAP011128
2 of 12
No
No
Agam\AgaP_AGAP011355
2 of 12
No
No
Agam\AgaP_AGAP011700
2 of 12
No
No
Agam\AgaP_AGAP012059
2 of 12
No
No
Agam\AgaP_AGAP012441
2 of 12
No
No
Agam\AgaP_AGAP013208
2 of 12
No
Yes
Agam\AgaP_AGAP000720
1 of 12
No
No
Agam\AgaP_AGAP001633
1 of 12
No
No
Agam\AgaP_AGAP001662
1 of 12
No
No
Agam\AgaP_AGAP001925
1 of 12
No
No
Agam\AgaP_AGAP002040
1 of 12
No
No
Agam\AgaP_AGAP002135
1 of 12
No
No
Agam\AgaP_AGAP002268
1 of 12
No
No
Agam\AgaP_AGAP002336
1 of 12
No
No
Agam\AgaP_AGAP002708
1 of 12
No
No
Agam\AgaP_AGAP002737
1 of 12
No
No
Agam\AgaP_AGAP002949
1 of 12
No
No
Agam\AgaP_AGAP003610
1 of 12
No
No
Agam\AgaP_AGAP003656
1 of 12
No
No
Agam\AgaP_AGAP004902
1 of 12
No
No
Agam\AgaP_AGAP005471
1 of 12
No
No
Agam\AgaP_AGAP006083
1 of 12
No
No
Agam\AgaP_AGAP007091
1 of 12
No
No
Agam\AgaP_AGAP007563
1 of 12
No
No
Agam\AgaP_AGAP009138
1 of 12
No
No
Agam\AgaP_AGAP009688
1 of 12
No
No
Agam\AgaP_AGAP010186
1 of 12
No
No
Agam\AgaP_AGAP010242
1 of 12
No
No
Agam\AgaP_AGAP010245
1 of 12
No
No
Agam\AgaP_AGAP010541
1 of 12
No
Yes
Agam\AgaP_AGAP010742
1 of 12
No
No
Agam\AgaP_AGAP010969
1 of 12
No
No
Agam\AgaP_AGAP010970
1 of 12
No
No
Agam\AgaP_AGAP012226
1 of 12
No
No
Agam\HPX4
1 of 12
No
No
Agam\IGL1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Lac. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (79)
Ama
8 of 13
DIP-β
8 of 13
DIP-ε
8 of 13
DIP-η
8 of 13
DIP-κ
8 of 13
DIP-ζ
8 of 13
DIP-δ
7 of 13
DIP-γ
7 of 13
DIP-ι
7 of 13
DIP-θ
7 of 13
DIP-α
6 of 13
DIP-λ
6 of 13
elff
4 of 13
fipi
4 of 13
klg
4 of 13
CG7166
3 of 13
CG13506
3 of 13
CG34353
3 of 13
bdl
2 of 13
CG6867
2 of 13
dpr1
2 of 13
dpr3
2 of 13
dpr4
2 of 13
dpr5
2 of 13
dpr6
2 of 13
dpr8
2 of 13
dpr9
2 of 13
dpr10
2 of 13
dpr11
2 of 13
dpr12
2 of 13
dpr13
2 of 13
dpr14
2 of 13
dpr15
2 of 13
dpr16
2 of 13
dpr17
2 of 13
dpr18
2 of 13
dpr19
2 of 13
dpr20
2 of 13
Dscam1
2 of 13
Dscam2
2 of 13
Dscam3
2 of 13
Dscam4
2 of 13
Fas2
2 of 13
kirre
2 of 13
Nrg
2 of 13
robo1
2 of 13
robo2
2 of 13
rst
2 of 13
sdk
2 of 13
tutl
2 of 13
wrapper
2 of 13
babos
1 of 13
boi
1 of 13
bt
1 of 13
btl
1 of 13
CG15312
1 of 13
CG17839
1 of 13
Cont
1 of 13
dpr2
1 of 13
dpr7
1 of 13
dpr21
1 of 13
ed
1 of 13
fra
1 of 13
ihog
1 of 13
ImpL2
1 of 13
kek4
1 of 13
Obsc
1 of 13
otk2
1 of 13
otk
1 of 13
plum
1 of 13
Ppn
1 of 13
Pxn
1 of 13
robo3
1 of 13
side-III
1 of 13
side-IV
1 of 13
sls
1 of 13
sns
1 of 13
Strn-Mlck
1 of 13
trol
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NEGR1; neuronal growth regulator 1
9 of 14
613173
       
      IGLON5; IgLON family member 5
      7 of 14
      618861
          LSAMP; limbic system associated membrane protein
          7 of 14
          603241
              NTM; neurotrimin
              7 of 14
              607938
                  OPCML; opioid binding protein/cell adhesion molecule like
                  7 of 14
                  600632
                  IGSF9B; immunoglobulin superfamily member 9B
                  3 of 14
                  613773
                      NCAM1; neural cell adhesion molecule 1
                      3 of 14
                      116930
                           
                          NCAM2; neural cell adhesion molecule 2
                          3 of 14
                          602040
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              esyN Network Diagram
                              Show neighbor-neighbor interactions:
                              Show/hide secondary interactors 
                              (data from AllianceMine provided by esyN)
                              Select Layout:
                              Legend:
                              Protein
                              RNA
                              Selected Interactor(s)
                              Other Interaction Browsers
                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                              Please see the Physical Interaction reports below for full details
                              protein-protein
                              Physical Interaction
                              Assay
                              References
                              Lac
                              bead aggregation assay, fluorescence microscopy, inferred by author, enzyme linked immunosorbent assay
                              (Ozkan et al., 2013, Strigini et al., 2006, Llimargas et al., 2004)
                              Lac - CG6959
                              enzyme linked immunosorbent assay
                              (Ozkan et al., 2013)
                              Summary of Genetic Interactions
                              esyN Network Diagram
                              Other Interaction Browsers
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              External Data
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Signaling Pathways (FlyBase)
                              Metabolic Pathways
                              FlyBase
                              External Links
                              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                              External Data
                              Class of Gene
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              2R
                              Recombination map
                              2-67
                              Cytogenetic map
                              49A6-49A7
                              Sequence location
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              49A6-49A7
                              Limits computationally determined from genome sequence between P{lacW}l(2)k11404k11404 and P{lacW}fdlk17040
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              Experimentally Determined Recombination Data
                              Location

                              2-67

                              (FlyBase, 2016)

                              2-68.6

                              (Comeron et al., 2012)
                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (14)
                              Genomic Clones (28)
                              cDNA Clones (197)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequenced
                              BDGP DGC clones
                              Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              Antibody Information
                              Laboratory Generated Antibodies
                               

                              polyclonal

                              (Llimargas et al., 2004)
                              Commercially Available Antibodies
                               
                              Cell Line Information
                              Publicly Available Cell Lines
                               
                                Other Stable Cell Lines
                                 
                                  Other Comments

                                  Embryos injected with dsRNA made from templates generated with primers directed against this gene show late epithelial embryonic defect - these embryos die following profound defects in the development of the tracheal epithelial tubes.

                                  (Pilot et al., 2006)

                                  Lac behaves as a homophilic cell adhesion molecule required to provide epithelial integrity to the tracheal tubes and to control tubular epithelium length.

                                  (Llimargas et al., 2004)

                                  Area matching Drosophila Lachesin gene, Acc. No. L13255.

                                  (Davies, 2001.3.15)

                                  Mutation in Lac alters tracheal tube size in embryos without affecting other aspects of tracheal development including primary branch budding and outgrowth or branch fusion.

                                  (Beitel and Krasnow, 2000)
                                  Relationship to Other Genes
                                  Source for database merge of

                                  Source for merge of: Lac bulb

                                  (Llimargas et al., 2004)
                                  Additional comments
                                  Nomenclature History
                                  Source for database identify of

                                  Source for identity of: bulb l(2)k11012

                                  (Beitel and Krasnow, 2000)
                                  Nomenclature comments
                                  Etymology
                                  Synonyms and Secondary IDs (11)
                                  Reported As
                                  Symbol Synonym
                                  CG12369
                                  (Bourquard et al., 2023, Hosono et al., 2015, Jaspers et al., 2012, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)
                                  CT24921
                                  (Hynes and Zhao, 2000)
                                  Lac
                                  (Lee et al., 2024, Olivares-Abril et al., 2024, Barbaste et al., 2023, Glashauser et al., 2023, Titlow et al., 2023, Voutyraki et al., 2023, Kotian et al., 2022, Alhadyian et al., 2021, Michki et al., 2021, Finegan and Bergstralh, 2020, Öztürk-Çolak et al., 2016, Chandran et al., 2014, Chen et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Saunders et al., 2013, Cherbas et al., 2011, Laprise et al., 2010, Christensen et al., 2009.7.22, Christensen et al., 2009.7.22, Jin et al., 2009, Tan et al., 2009, Christensen et al., 2008.4.15, Yi et al., 2008, Araujo et al., 2007, Christensen and Cook, 2007.5.8, Kaltenbach et al., 2007, Furuse and Tsukita, 2006, Pilot et al., 2006, Strigini et al., 2006, Llimargas et al., 2004)
                                  bulb
                                  (Tonning et al., 2005, Behr et al., 2003)
                                  l(2)k11012
                                  (Bowman, 2000.3.30, Spradling et al., 1999)
                                  l(2)k11012b
                                  (Beitel and Krasnow, 2000)
                                  lac
                                  (Rouka et al., 2021, Stork et al., 2009, Wu et al., 2007, Wu and Beitel, 2004)
                                  Name Synonyms
                                  Lachesin
                                  (Rice et al., 2021, Cheng et al., 2019, Kubick et al., 2018, Wang et al., 2018, Chandran et al., 2014, Firmino et al., 2013, Jaspers et al., 2012, Leiserson and Keshishian, 2011, Rodrigues et al., 2011, Khanna et al., 2010, Laprise et al., 2010, Stork et al., 2008, Yi et al., 2008, Araujo et al., 2007, Kaltenbach et al., 2007, Wu et al., 2007, Pilot et al., 2006, Strigini et al., 2006)
                                  bulbous
                                  lachesin
                                  (Axelrod et al., 2023, Stork et al., 2009, Morin et al., 2001, Karlstrom, 1993.3.25)
                                  lachesin bulbous
                                  (Wu and Beitel, 2004)
                                  Secondary FlyBase IDs
                                  • FBgn0021933
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  Study result (0)
                                  Result
                                  Result Type
                                  Title
                                  External Crossreferences and Linkouts ( 60 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                  Other crossreferences
                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                  FlyMine - An integrated database for Drosophila genomics
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  DroID - A comprehensive database of gene and protein interactions.
                                  DRSC - Results frm RNAi screens
                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  Flygut - An atlas of the Drosophila adult midgut
                                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                  References (115)