FlyBase Gene Report: Dmel\Rbp4

General Information

Symbol

Dmel\Rbp4

Species

D. melanogaster

Name

RNA-binding protein 4

Annotation Symbol

CG9654

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010258

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

RNA-binding protein 4 (Rbp4) encodes a protein that mediates the translational repression of CycB during meiosis in males. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Tsr, RRM4

Key Links

Genomic Location

Cytogenetic map

87F7-87F7

Sequence location

3R:13,654,556..13,656,394 [-]

Recombination map

3-54

RefSeq locus

NT_033777 REGION:13654556..13656394

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables mRNA 3'-UTR binding

inferred from direct assay

(Baker et al., 2015)

enables single-stranded RNA binding

inferred from direct assay

(Haynes et al., 1997)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables mRNA binding

inferred from sequence or structural similarity with SGD:S000005483

(FlyBase Curators, 2008--)

inferred from sequence or structural similarity

(Lasko, 2000)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mRNA processing

inferred from sequence or structural similarity with SGD:S000005483

(FlyBase Curators, 2008--)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Baker et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

RNA-binding protein 4 (Rbp4) encodes a protein that mediates the translational repression of CycB during meiosis in males. [Date last reviewed: 2019-09-19]

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rbp4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rbp4-RA

FBtr0082853

NM_057587

1515

428

Additional Transcript Data and Comments

Reported size (kB)

1.7 (northern blot)

(Haynes et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Rbp4-PA

FBpp0082318

46.6

428

9.86

NP_476935

AAF54966

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

428 (aa); 47 (kD predicted)

(Haynes et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbp4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Rbp4_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

spermatogenesis & adult stage | male

spermatocyte

(Lu et al., 2013)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

(Haynes et al., 1997)

pupal stage

(Haynes et al., 1997)

adult stage | male

(Haynes et al., 1997)

Additional Descriptive Data

Rbp4 transcripts are expressed only in the germ line of males and is likely to be testis specific.

(Haynes et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

spermatocyte

(Haynes et al., 1997)

spermatid

(Haynes et al., 1997)

testis

(Haynes et al., 1997)

Additional Descriptive Data

Rbp4 protein is detected in the testis. No staining is observed in the germ line stem cells at the apical tip of the testis. Rbp4 protein is first detected in young primary spermatocytes and continues to accumulate as the spermatocytes develop. The highest levels are seen in cells immediately following meiosis. Protein persists until later stages of spermatid elongation but is not detected in fully elongated spermatids.

(Haynes et al., 1997)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Baker et al., 2015)

Expression Deduced from Reporters

Reporter: P{Rbp4-EYFP}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

testis

(Baker et al., 2015)

primary spermatocyte

(Baker et al., 2015)

mature primary spermatocyte

(Baker et al., 2015)

polar primary spermatocyte

(Baker et al., 2015)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rbp4 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rbp4

View exonic expression by tissue for Dmel\Rbp4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB

41668/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0010258

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9654-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9654

Flygut - An atlas of the Drosophila adult midgut

FBgn0010258

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rbp4

Transgenic constructs containing regulatory region of Rbp4

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6169

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)Hrb87F

(Singh and Lakhotia, 2012)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Rbp4¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rbp4^GD14281

viable, with Scer\GAL4^Mef2.PR

Rbp4^GD14281

viable, with Scer\GAL4^pnr-MD237

Rbp4^GD14281

Sterility

Allele

female fertile

Rbp4¹

male semi-fertile

Rbp4¹

Other Phenotypes

Allele

abnormal cytokinesis (with Df(3R)Exel6169)

Rbp4^LL06910

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (30)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HNRNPA1

3 of 15

Yes

Hsap\HNRNPA3

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (33)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Hnrnpa1

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (30)

Rnor\Hnrnpa1

2 of 13

Yes

Rnor\Hnrnpa2b1

2 of 13

Yes

Rnor\LOC681410

2 of 13

Yes

Rnor\LOC103689931

2 of 13

Yes

Rnor\Slirp

2 of 13

Yes

Rnor\Boll

1 of 13

Rnor\Cirbp

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (22)

Xtro\hnrnpa0

2 of 12

Yes

Xtro\hnrnpa1

2 of 12

Yes

Xtro\hnrnpa2b1

2 of 12

Yes

Xtro\hnrnpa3

2 of 12

Yes

Xtro\hnrnpab

2 of 12

Yes

Xtro\cirbp

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (38)

Drer\hnrnpa3

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Drer\cirbpb

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\zgc:55733

1 of 15

Drer\zgc:110796

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\hrp-1

2 of 15

Yes

Cele\slrp-1

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (27)

Atha\AT1G01080

1 of 9

Yes

Atha\AT1G60000

1 of 9

Yes

Atha\AT2G22088

1 of 9

Yes

Atha\AT2G22100

1 of 9

Yes

Atha\AT2G33410

1 of 9

Yes

Atha\AT2G35410

1 of 9

Yes

Atha\AT2G37220

1 of 9

Yes

Atha\AT2G41060

1 of 9

Yes

Atha\AT3G07810

1 of 9

Yes

Atha\AT3G13224

1 of 9

Yes

Atha\AT3G15010

1 of 9

Yes

Atha\AT4G09040

1 of 9

Yes

Atha\AT4G14300

1 of 9

Yes

Atha\AT4G26650

1 of 9

Yes

Atha\AT5G03495

1 of 9

Yes

Atha\AT5G47620

1 of 9

Yes

Atha\AT5G51730

1 of 9

Yes

Atha\AT5G53700

1 of 9

Yes

Atha\AT5G55550

1 of 9

Yes

Atha\CP29

1 of 9

Yes

Atha\CP31B

1 of 9

Yes

Atha\CP33

1 of 9

Yes

Atha\NUC-L1

1 of 9

Yes

Atha\NUC-L2

1 of 9

Yes

Atha\PHIP1

1 of 9

Yes

Atha\RBP31

1 of 9

Yes

Atha\UBA2A

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (17)

Scer\HRP1

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\MUD1

1 of 15

Scer\NAB3

1 of 15

Scer\NAB6

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\TIF3

1 of 15

Scer\WHI3

1 of 15

Scer\WHI4

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\tcg1

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A5D )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA26466

Drosophila persimilis

Dper\GL23972

Drosophila willistoni

Dwil\GK13335

Drosophila virilis

Dvir\GJ23112

Drosophila mojavensis

Dmoj\GI10693

Drosophila grimshawi

Dgri\GH19059

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G1CPI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_022512gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hnrpa

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dazap

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Msi1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hnrpa2B1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_9

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dazap_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007318gn

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022958

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000017374

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003877

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003362

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000013663

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018579

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004062

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000016737

Gallus gallus

Domestic chicken

Ggal\DAZAP1

Gallus gallus

Domestic chicken

Ggal\HNRNPA0

Gallus gallus

Domestic chicken

Ggal\HNRNPA2B1

Gallus gallus

Domestic chicken

Ggal\HNRNPAB

Gallus gallus

Domestic chicken

Ggal\HNRNPA3

Gallus gallus

Domestic chicken

Ggal\HNRPDL

Gallus gallus

Domestic chicken

Ggal\MSI2

Gallus gallus

Domestic chicken

Ggal\HNRNPD

Gallus gallus

Domestic chicken

Ggal\MSI2

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028932

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (34)

Gene Symbol

Score

Source

Alignment

4 of 10

4 of 10

4 of 10

3 of 10

2 of 10

2 of 10

2 of 10

msi

2 of 10

Rbp6

2 of 10

Secp43

2 of 10

SLIRP1

2 of 10

sqd

2 of 10

ssx

2 of 10

tra2

2 of 10

bol

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Sxl

1 of 10

Syp

1 of 10

TBPH

1 of 10

trv

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

HNRNPA1; heterogeneous nuclear ribonucleoprotein A1

model of inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3

IEA

(FlyBase, 2019-)

model of amyotrophic lateral sclerosis type 20

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HNRNPA1; heterogeneous nuclear ribonucleoprotein A1

3 of 15

164017

HNRNPA3; heterogeneous nuclear ribonucleoprotein A3

3 of 15

605372

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rbp4 - fest

anti tag coimmunoprecipitation, anti tag western blot

(Baker et al., 2015)

RNA-protein

Physical Interaction

Assay

References

Rbp4 - CycB

pull down, anti tag western blot

(Baker et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66749

DroID - A comprehensive database of gene and protein interactions.

FBgn0010258

MIST (protein-protein) - An integrated Molecular Interaction Database

Rbp4

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

mRNA surveillance pathway

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-54

Cytogenetic map

87F7-87F7

Sequence location

3R:13,654,556..13,656,394 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87F7-87F7

Limits computationally determined from genome sequence between P{PZ}CtBP⁰³⁴⁶³ and P{lacW}B52^s2249&P{lacW}flfl^L4179

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

87F-87F

(Haynes, 1994.12.12)

Experimentally Determined Recombination Data

Location

3-54

(FlyBase, 2016)

3-51.0

(Comeron et al., 2012)

(Haynes, 1994.12.12)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Bloomington

67702

y¹ w^*; P{Rbp4⁺}2/SM6a

Kyoto

141934

y^* w^*; P{FRT(w^hs)}2A P{neoFRT}82B PBac{SAstopDsRed}Rbp4^LL06910 P{Car20y}96E / TM6B, Tb¹

VDRC

v29116

w¹¹¹⁸; P{GD14281}v29116

v318563

PBac{fTRG00391.sfGFP-TVPTBF}VK00033

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT27014

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010258

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010258

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41668

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Haynes et al., 1997)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Rbp4 has been cloned and characterised.

(Haynes et al., 1997)

Rbp4 mutant males are weakly fertile producing low numbers of motile sperm.

(Haynes et al., 1995)

A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.

(Kim and Baker, 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41668

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010258

DRscDB

41668/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0010258

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Rbp4_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9654

Flygut - An atlas of the Drosophila adult midgut

FBgn0010258

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41668

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9654

MARRVEL_MODEL

41668

modMine - A data warehouse for the modENCODE project

FBgn0010258

Linkouts

BioGRID - A database of protein and genetic interactions.

66749

DroID - A comprehensive database of gene and protein interactions.

FBgn0010258

DRSC - Results frm RNAi screens

FBgn0010258

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9654-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010258

FlyMine - An integrated database for Drosophila genomics

FBgn0010258

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

mRNA surveillance pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

Rbp4

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG9654

(Singh and Lakhotia, 2012)

RRM4

(Kim, 1993.3.10)

Rbp4

(Haynes, 2017.5.2, Kim et al., 2017, Li et al., 2016, Sarov et al., 2016, Lu and Fuller, 2015, Liang et al., 2014, Lu et al., 2013, Rincon-Arano et al., 2012, Rasmussen and Kellis, 2007, Stanyon et al., 2004)

TSR

(Lal et al., 2003, Blumer et al., 2002, Haynes, 1999)

Tsr

(Singh and Lakhotia, 2012, Mallik and Lakhotia, 2010, Haynes, 2000, Pazman et al., 2000, Haynes et al., 1997, Haynes et al., 1997, Haynes et al., 1995, Schafer et al., 1995, Stolow and Haynes, 1995, Haynes, 1994.12.12)

rbp4

(Fingerhut et al., 2019, Baker et al., 2015)

rrm4

(Kim and Baker, 1993)

tsr

(Mallik and Lakhotia, 2010)

Name Synonyms

RNA-binding protein 4

(Shieh and Bonini, 2011)

Testis specific RRM protein

Secondary FlyBase IDs

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Study focus (0)

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