Tsr, RRM4
Please see the JBrowse view of Dmel\Rbp4 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.47
1.7 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
428 (aa); 47 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbp4 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Rbp4 transcripts are expressed only in the germ line of males and is likely to be testis specific.
Rbp4 protein is detected in the testis. No staining is observed in the germ line stem cells at the apical tip of the testis. Rbp4 protein is first detected in young primary spermatocytes and continues to accumulate as the spermatocytes develop. The highest levels are seen in cells immediately following meiosis. Protein persists until later stages of spermatid elongation but is not detected in fully elongated spermatids.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Rbp4 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Rbp4 has been cloned and characterised.
Rbp4 mutant males are weakly fertile producing low numbers of motile sperm.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.