fs(2)B, fes, female sterile(2)Bridges, RRM9, RRM10
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Stop-codon suppression (UAA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.52
444, 439 (aa); 50 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbp9 using the Feature Mapper tool.
Rbp9 is found in region 2a of the germarium, remains high in region 2b, diminishes in region 3 as egg chambers form, and becomes undetectable beyond stage 3 egg chambers.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rbp9 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Rbp9 CG5808
Annotations CG3151 and CG15402 merged as CG3151 in release 3 of the genome annotation.
Area matching Drosophila rbp9 gene, Acc. No. S55886.
Rbp9 is required during the cystocyte differentiation stage in females for the maintenance of germline sexual identity.
Rbp9 protein binds bam mRNA to down-regulate bam protein expression. The concentrated localization of Rbp9 protein in the oocyte of the early egg chambers may be required for proper oocyte determination or positioning.
Mutants show a female sterility phenotype, due to defective oogenesis, rather than neuronal defects.
The consensus Rbp9 binding site, UUUXUUUU, is present in two copies in the 3' untranslated region of emc mRNA. UV crosslinking demonstrates a specific interaction between the two, and Northern analysis revealed that Rbp9 functions as a regulator of mRNA stability.
Mutants display germline hyperplastic phenotype.
Rbp9 is molecularly characterised and expression pattern determined. Results suggest Rbp9 may be involved in the development of the nervous system perhaps by acting as a regulator of nervous system-specific RNA processing decisions.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
Bridges, 25th March 1929.