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Gene Dmel\Dsor1

General Information
Symbol	Dmel\Dsor1	Species	D. melanogaster
Name	Downstream of raf1	Annotation symbol	CG15793
Feature type	protein_coding_gene	FlyBase ID	FBgn0010269
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	MEK, Dsor, MAPKK, D-MEK, DRODSOR1, SOR, D-SOR, Dmek
Genomic Location
Chromosome (arm)	X	Recombination map	1-27.6
Cytogenetic map	8D2-8D3	Sequence location	X:9,141,375..9,144,074 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Downstream of raf1 is referred to in FlyBase by the symbol Dmel\Dsor1 (CG15793, FBgn0010269). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: MAP kinase kinase activity. There is experimental evidence that it is involved in the biological process: terminal region determination; border follicle cell migration; hemocyte differentiation; signal transduction. 40 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; organ system; histaminergic neuron; adult segment; pigment cell; thoracic segment; non-connected developing system; acellular anatomical structure. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1626006_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dsor1. Gene sequence location is X:9141375..9144074.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8D2-8D3   Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912
Experimentally Determined Cytological Location
Cytogenetic map Notes References 8D-8D     (Nishida, 1992.11.27) 8D-8D   (determined by in situ hybridisation)   (Tsuda et al., 1993)
Experimentally Determined Recombination Data
Location	1-27.6 (Nishida, 1992.11.27)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dsor1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dsor1-RA FBtr0071313  NM_078543   1799   396 Dsor1-RB FBtr0340120     1507   393
Additional Transcript Data & Comments
Reported size (kB)	2.0 (northern blot) (Tsuda et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dsor1-PA   FBpp0071248   43.9   396   6.25     NP_511098   AAF46475 Dsor1-PB   FBpp0309113   43.5   393   6.15
Additional Polypeptide Data & Comments
Reported size (kDa)	393 (aa); 44 (kD) (Tsuda et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246723   AE014298 AAF46475   AI514711   AJ569103   AJ569104   AJ569106   AJ569107   AJ569108   AJ569109   AJ569110   AJ569111   AJ569112   AJ569113   AJ569114   AJ569115   AJ569117   AJ569118   AJ569119   AJ569120   AJ569121   AJ569122   AJ569123   AJ569124   AJ569125   AJ569126   AJ569128   AJ569129   AY058692 AAL13921   AY135075 AAN17587   AY135076 AAN17588   AY135077 AAN17589   AY135078 AAN17590   AY135079 AAN17591   AY135080 AAN17592   AY135081 AAN17593   AY135082 AAN17594   AY135083 AAN17595   AY135084 AAN17596   AY135085 AAN17597   AY135086 AAN17598   AY135087 AAN17599   AY135088 AAN17600   AY135089 AAN17601   AY135090 AAN17602   AY135091 AAN17603   AY135092 AAN17604   AY135093 AAN17605   CA806639   CO287807   D13782 BAA02925   EC051294   EC052375   EC053844   EC055023   EC055040   EC055338   EC055890   EC056072   EC056208   EC056305   EC059103   EC059529   EC081470   EV578441   GH974496   GH981145   HM449888
UniProtKB/Swiss-Prot	Q24324
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Tsuda et al., 1993)
Additional Descriptive Data
	Dsor1 transcripts are expressed throughout development and are particularly abundant in early embryos. (Tsuda et al., 1993)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis    17.1 Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    83.9   NA  Eye    77.125   NA  Brain    215.1   189.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    179.7   NA  Crop    73.2   94.3  Midgut    66.7   125.2  Hindgut    104.1   136.1  Malpighian Tubules    118.6   61.7  Fat Body    56.6   116.2  Salivary Gland    130   NA  Heart    80.375   90.875  Trachea    NA   NA  VirginFemale Spermatheca    75.9   NA  InseminatedFemale Spermatheca    73   NA  Ovary    213.8   NA  Testis    no informative data   NA  Male Accessory Gland    104.9   96.875  Carcass    77.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female    45 ovary, mated 4-day female    39 testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3  (27) central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female  (45) ovary, mated 4-day female  (39) testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female    45 ovary, mated 4-day female    39 testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female    45 ovary, mated 4-day female    39 testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female    45 ovary, mated 4-day female    39 testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3  27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female  (45) ovary, mated 4-day female  (39) testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female    45 ovary, mated 4-day female    39 testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    27 central nervous system, pupae P8    18 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    12 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    10 digestive system, 4-day adult    9 digestive system, 20-day adult    12 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    10 carcass, larvae L3 wandering    20 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    9 ovary, virgin 4-day female    45 ovary, mated 4-day female    39 testis, mated 4-day male    4 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    26 embryo 04-06hr    36 embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr    33 pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day    26 adult female 05day    42 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  26 embryo 04-06hr  (36) embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr  (33) pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day  26 adult female 05day  (42) adult female 30day  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    26 embryo 04-06hr    36 embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr    33 pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day    26 adult female 05day    42 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    26 embryo 04-06hr    36 embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr    33 pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day    26 adult female 05day    42 adult female 30day    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    26 embryo 04-06hr    36 embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr    33 pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day    26 adult female 05day    42 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  26 embryo 04-06hr  (36) embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr  (33) pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day  26 adult female 05day  (42) adult female 30day  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    26 embryo 04-06hr    36 embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr    33 pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day    26 adult female 05day    42 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    26 embryo 04-06hr    36 embryo 06-08hr    18 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    10 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    24 white prepupae 24hr    33 pupae 2d postWPP    18 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    10 adult female 01day    26 adult female 05day    42 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2    29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2  (29) embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3    20 wing disc ML-DmD21  (30) wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (28) eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2  (29) tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2    29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2    29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2    29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2  29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3    20 wing disc ML-DmD21  30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2  29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2    29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    15 embryonic GM2    29 embryonic Kc167    15 embryonic S1    19 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    30 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3  (34) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3  (34) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD41207 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010269 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15793-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Dsor1LH110 lethal | adult stage | recessive Dsor1XS520 lethal | embryonic stage | recessive Dsor1LH110 lethal | polyphasic Dsor1LH110 lethal | pupal stage, with Scer\GAL4pnr-MD237 Dsor1GD9123 lethal | recessive Dsor1756 Dsor1r1 Dsor1r2 Dsor1S-1221 Dsor1unspecified Other Phenotypes Allele neuroanatomy defective | embryonic stage Dsor1LH110 visible Dsor1XS520 visible, with Scer\GAL4pnr-MD237 Dsor1GD9123 visible | dominant Dsor1XS520 visible | recessive Dsor1XS520 wild-type Dsor1+t9 Phenotype manifest in Allele chorion | maternal effect | somatic clone Dsor1756 dorsal appendage Dsor1ts1 egg chamber | maternal effect | somatic clone Dsor1756 embryonic dorsal epidermis Dsor1LH110 eye Dsor1LF133 Dsor1Su1 Dsor1XS520 eye photoreceptor cell Dsor1XS520 germarium, with Scer\GAL4unspecified Dsor1VDRC.cUa imaginal disc | somatic clone Dsor1Gp158 Dsor1r1 intermediate ventral neurectoderm Dsor1LH110 mesothoracic tergum, with Scer\GAL4pnr-MD237 Dsor1GD9123 ommatidium Dsor1Su1 Dsor1Su12 Dsor1Su18 Dsor1Su24 Dsor1Su4 Dsor1Su6 Dsor1Su7 Dsor1XS520 photoreceptor cell R1 Dsor1XS520 photoreceptor cell R2 Dsor1XS520 photoreceptor cell R3 Dsor1XS520 photoreceptor cell R4 Dsor1XS520 photoreceptor cell R5 Dsor1XS520 photoreceptor cell R6 Dsor1XS520 photoreceptor cell R7 Dsor1Su1 Dsor1Su12 Dsor1Su4 Dsor1Su6 Dsor1Su7 Dsor1XS520 Dsor1ts1 pigment cell Dsor1Su1 spectrosome | supernumerary, with Scer\GAL4unspecified Dsor1VDRC.cUa wing vein Dsor1XS520
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of Dsor1 Class Mutagen Stocks Known lesion Dsor1LH110 amorphic allele - genetic evidence, loss of function allele 1 -- Dsor1G42 ethyl methanesulfonate 1 -- Dsor1G79 ethyl methanesulfonate 1 -- Dsor1G9740 P-element activity 1 -- Dsor1S-1221 ethyl methanesulfonate 1 -- Dsor11 0 -- Dsor1756 ethyl methanesulfonate 0 -- Dsor1Gp158 Delta2-3 0 Yes Dsor1LF133 0 -- Dsor1MAPKK 0 -- Dsor1r1 ethyl methanesulfonate 0 -- Dsor1r2 ethyl methanesulfonate 0 -- Dsor1Su12 0 Yes Dsor1Su18 0 Yes Dsor1Su1 gain of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dsor1Su24 0 Yes Dsor1Su34B ethyl methanesulfonate 0 Yes Dsor1Su4 0 Yes Dsor1Su5 0 Yes Dsor1Su6 0 Yes Dsor1Su7 0 Yes Dsor1unspecified 0 -- Dsor1XS520 hypomorphic allele - genetic evidence X ray 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dsor1 Class Mutagen Stocks Known lesion Dsor1GD9123 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dsor1GL00096 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1GLV21003 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1HMS00037 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1HMS00145 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1HMS00710 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1JF01697 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1JF03100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1KK102276 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1+t9 in vitro construct - genomic fragment 0 Yes Dsor12E.MtnA.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes Dsor1D83V in vitro construct - amino acid replacement 0 Yes Dsor1DA.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Dsor1dsRNA.cCa in vitro construct - RNAi 0 Yes Dsor1ts1 in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Dsor1ts2 in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Dsor1VDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)10-70d (Santamaria and Randsholt, 1995) Df(1)BSC537 (Christensen et al., 2008.6.11) Df(1)BSC538 (Christensen et al., 2008.6.11) Df(1)BSC663 (Christensen et al., 2008.12.28) Df(1)Exel9049 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9123} NA P{KK102276} NA P{TRiP.GL00096} NA P{TRiP.GLV21003} NA P{TRiP.HMS00037} NA P{TRiP.HMS00145} NA P{TRiP.HMS00710} NA P{TRiP.JF01697} NA P{TRiP.JF03100} NA characterization construct P{D-mekD83V} NA P{D-mekts1} NA P{D-mekts2} NA P{D-mekwt-20J} NA P{VDRC.Dsor1.U} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Dsor1Gp158 NA insertion of mobile activating element P{EP}Dsor1G9740 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
border follicle cell migration inferred from genetic interaction with sl (Bianco et al., 2007) hemocyte differentiation inferred from genetic interaction with hop (Luo et al., 2002) signal transduction inferred from genetic interaction with phl (Tsuda et al., 1993) inferred from mutant phenotype (Hsu and Perrimon, 1994) terminal region determination inferred from mutant phenotype (Jimenez et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) MAP kinase activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) MAP kinase kinase activity inferred from sequence or structural similarity (Noselli and Glise, 1996, Lim et al., 1997) non-traceable author statement (Nishida, 1992.11.27) traceable author statement (Martin-Blanco, 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) receptor signaling protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
anterior/posterior axis specification, embryo traceable author statement (Baek and Lee, 1999) epidermal growth factor receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) MAPK cascade non-traceable author statement (Martin-Blanco, 2000) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) traceable author statement (Kumar and Moses, 2000) regulation of Toll signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) sevenless signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) torso signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dsor1 - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Arf102F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - BicD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG10628 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG1444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG2972 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG31918 experimental knowledge based (Guruharsha et al., 2011) Dsor1 - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG8728 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - CG9775 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Cen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - RpS10a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - RpS27A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Ski6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - cbs experimental knowledge based (Guruharsha et al., 2011) Dsor1 - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - ksr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - larp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mRpL15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mRpL45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mRpL51 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - ox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dsor1 - vret experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Dsor1 - wal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dsor1 allele Gene References Dsor1+t9 phl (Hsu and Perrimon, 1994) Dsor1Gp158 aos (Sawamoto et al., 1996) rl (Lim et al., 1999) Dsor1LF133 svp (Kramer et al., 1995) W (Kurada and White, 1998) Dsor1LH110 Src42A (Lu et al., 1994) Su(phl)4 (Lu et al., 1994) Su(phl)6 (Lu et al., 1994) Su(phl)7 (Lu et al., 1994) Su(phl)9 (Lu et al., 1994) Su(phl)43B (Lu et al., 1994) Dsor1r1 phl (Li et al., 2000) rl (Lim et al., 1999) Src42A (Takahashi et al., 1996) tor (Li and Li, 2003) Dsor1r2 if (Baker et al., 2002) Dsor1S-1221 aop (Karim et al., 1996) hop (Luo et al., 2002) Ras85D (Karim et al., 1996) Dsor1Su1 aos (Sawamoto et al., 1996) asp (Inoue and Glover, 1998) cln (Taguchi et al., 2000) csw (Tsuda et al., 1993) Egfr (Lim et al., 1997) fs(1)M3 (Lim et al., 1999) lace (Adachi-Yamada et al., 1999) N (Nagaraj et al., 1999) phl (Tsuda et al., 1993, Lim et al., 1997) rpr (Kurada and White, 1998) sev (Lim et al., 1997) Sos (Lim et al., 1997, Taguchi et al., 2000) tor (Lim et al., 1997, Lim et al., 1999) W (Sawamoto et al., 1998, Kurada and White, 1998) Dsor1Su4 Egfr (Lim et al., 1997) Sos (Lim et al., 1997) Dsor1Su7 Sos (Lim et al., 1997) Dsor1Su12 phl (Lim et al., 1997) sev (Lim et al., 1997) tor (Lim et al., 1997) Dsor1Su18 phl (Lim et al., 1997) sev (Lim et al., 1997) Sos (Lim et al., 1997) tor (Lim et al., 1997) Dsor1Su24 phl (Lim et al., 1997) sev (Lim et al., 1997) Sos (Lim et al., 1997) tor (Lim et al., 1997) Dsor1Su34B Egfr (Zhang et al., 1999) phl (Lu et al., 1994, Zhang et al., 1999) rl (Zhang et al., 1999) sag (Zhang et al., 1999) Su(SuRaf1)IV (Zhang et al., 1999) Dsor1unspecified ksr::tor (Therrien et al., 2000) Ras85D (Therrien et al., 2000) Dsor1XS520 aop (Karim et al., 1996) ER2-1 (Karim et al., 1996) ER2-3 (Karim et al., 1996) ER2-4 (Karim et al., 1996) ER2-7B (Karim et al., 1996) ER3-2 (Karim et al., 1996) ER3-4 (Karim et al., 1996) hh (Karim et al., 1996) hop (Luo et al., 2002) ksr (Karim et al., 1996) mam (Karim et al., 1996) mts (Karim et al., 1996) pnt (O'Neill et al., 1994) PTP-ER (Karim et al., 1996, Karim and Rubin, 1999) Ras85D (Karim et al., 1996) rl (Karim et al., 1996) SR3-6 (Karim et al., 1996) Src42A (Lu and Li, 1999) Taf6 (Karim et al., 1996) unspecified 14-3-3ε (Karim et al., 1996) ebi (Tsuda et al., 1997) ksr (Therrien et al., 2000) PDZ-GEF (Lee et al., 2002) phl (Lim et al., 1997) Ras85D (O'Neill et al., 1994) S6kII (Kim et al., 2006) sev (Lim et al., 1997) tor (Lim et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58322 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010269 DroID - A comprehensive database of gene and protein interactions. • FBgn0010269 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31872 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24324
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N317T Dipteran inclusive ortholog search EOG6V9V08 Insect inclusive ortholog search EOG6P8DFB Arthropod inclusive ortholog search EOG69W0XM Metazoa inclusive ortholog search EOG6W9WX9
Orthologs in Drosophila Species (EOG6N317T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dsor1     Drosophila simulans   Dsim\Dsor1 Y   Drosophila sechellia   Dsec\GM22414 Y   Drosophila erecta   Dere\GG18305 Y   Drosophila yakuba   Dyak\GE17784 Y   Drosophila ananassae   Dana\Dsor1 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13960 Y   Drosophila persimilis   Dper\GL16493 Y   Drosophila willistoni   Dwil\GK25111 Y   Drosophila virilis   Dvir\GJ18839 Y   Drosophila mojavensis   Dmoj\GI15238 Y   Drosophila grimshawi   Dgri\GH12793 Y
Orthologs in non-Drosophila Dipterans (EOG6V9V08)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012723   Anopheles gambiae Malaria mosquito  Agam\AGAP001103   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015801
Orthologs in non-Dipteran Insects (EOG6P8DFB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41067   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007628   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22565   Atta cephalotes Leafcutter ant  Acep\ACEP16116   Camponotus floridanus Florida carpenter ant  Cflo\CFLO26012   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19693   Linepithema humile Argentine ant  Lhum\LH13340   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14827   Solenopsis invicta Red fire ant  Sinv\SINV16716   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000770   Bombyx mori Silkmoth  Bmor\BGIBMGA001458   Pediculus humanus Human body louse  Phum\PHUM413460   Tribolium castaneum Red flour beetle  Tcas\TC004803
Orthologs in non-Insect Arthropods (EOG69W0XM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_46211   Ixodes scapularis Deer tick  Isca\ISCW005428
Orthologs in non-Arthropod Metazoa (EOG6W9WX9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mek-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009399gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021504gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009398gn   Danio rerio Zebrafish  Drer\map2k2b   Danio rerio Zebrafish  Drer\map2k2   Danio rerio Zebrafish  Drer\map2k5   Danio rerio Zebrafish  Drer\map2k1   Xenopus tropicalis Western clawed frog  Xtro\map2k5   Xenopus tropicalis Western clawed frog  Xtro\map2k1   Gallus gallus Domestic chicken  Ggal\MAP2K5   Gallus gallus Domestic chicken  Ggal\MAP2K1   Gallus gallus Domestic chicken  Ggal\MAP2K2   Mus musculus House mouse  Mmus\Map2k2   Mus musculus House mouse  Mmus\Map2k5   Mus musculus House mouse  Mmus\Map2k1   Rattus norvegicus Norway rat  Rnor\Map2k2   Rattus norvegicus Norway rat  Rnor\Map2k5   Rattus norvegicus Norway rat  Rnor\Map2k1   Homo sapiens Human  Hsap\MAP2K5   Homo sapiens Human  Hsap\MAP2K1   Homo sapiens Human  Hsap\MAP2K2
Human Orthologs (3)
Gene OMIM HGNC Hsap\MAP2K5     Hsap\MAP2K1     Hsap\MAP2K2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Dsor1 Drosophila sechellia Dsec\GM22414 Drosophila erecta Dere\GG18305 Drosophila yakuba Dyak\GE17784 Drosophila ananassae Dana\Dsor1 Drosophila pseudoobscura pseudoobscura Dpse\GA13960 Drosophila persimilis Dper\GL16493 Drosophila willistoni Dwil\GK25111 Drosophila virilis Dvir\GJ18839 Drosophila mojavensis Dmoj\GI15238 Drosophila grimshawi Dgri\GH12793
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	33284 w* P{EP}Dsor1G9740 28685 y1 v1; P{TRiP.JF03100}attP2 31184 y1 v1; P{TRiP.JF01697}attP2 33639 y1 v1; P{TRiP.HMS00037}attP2 8496 y1 wa Dsor1S-1221/Basc 7136 w1 Dsor1G79/FM7c/Dp(1;Y)FF1, y+ 7131 y1 ac1 z1 Dsor1G42/FM7a 34830 y1 sc* v1; P{TRiP.HMS00145}attP2 36099 y1 sc* v1; P{TRiP.GLV21003}attP2
VDRC	v107276 P{KK102276}VIE-260B v40026 w1118; P{GD9123}v40026 v40025 w1118; P{GD9123}v40025/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR30C13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD41207
Other clones	DPiM_LD41207
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD05838
Other clones	CK01.84A.C12 CK01.98B.E7 CK01.118A.D5 Dmel_dig_017906_0680_2891 EC051294 EC052375 EC053844 EC055023 EC055040 EC055338 EC055890 EC056072 EC056208 EC056305 EK066844 ESG014b.E21_D07 RP004235055 RP004362344
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31872
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Wild-type Dsor1 does not complement the mating defect of S.cerevisiae Scer\ste7 mutants. A mutated form of Dsor1 (carrying the lesion found in Dsor1Su1) does complement the mating defect of S.cerevisiae Scer\ste7 mutants. Wild-type Dsor1 does not complement the temperature-sensitive cell-lysis defect of S.cerevisiae Scer\MKK1 Scer\MKK2 double mutants. A mutated form of Dsor1 (carrying the lesion found in Dsor1Su1) does complement the temperature-sensitive cell-lysis defect of S.cerevisiae Scer\MKK1 Scer\MKK2 double mutants. Wild-type Dsor1 or a mutated form of Dsor1 (carrying the lesion found in Dsor1Su1) does not complement the sensitivity to osmotic pressure of S.cerevisiae Scer\pbs2 mutants. (Lim et al., 1997)
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Douziech et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The MAPK cascade is required for Ras85D mitogenic response, loss of function mutations in phl, Dsor1, rl and ksr dominantly suppress hyperplastic growth, as do mutations in the Ras85D effector loop that disrupt the Ras85D-phl interaction. (Karim and Rubin, 1998) Downstream signal transducer of torso, sevenless and DER receptors. (Noselli and Glise, 1996) Studies of interaction between argos and members of the Ras/MAPK pathway demonstrate the argos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade. (Sawamoto et al., 1996) Expression of Dsor1 in lin-3, let-23 or lin-45 C.elegans mutants permits P5.p, P6.p and P7.p segments to adopt the vulval fates in each of the vulvaless backgrounds. (Koga and Ohshima, 1995) Additional alleles of Dsor1 have been isolated in screen for lethal mutations that fail to complement Df(1)10-70d. (Santamaria and Randsholt, 1995) A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl. (Therrien et al., 1995) Down-regulation of bcd activity depends on the function of Dsor1. Dsor1 acts downstream of phl in the tor pathway and encodes a MAP-kinase kinase (MAPKK). Several clustered consensus sites for MAP kinase phosphorylation can be found in the bcd coding sequence. (Dostatni et al., 1994) Dsor1 acts downstream of phl in the DER pathway. (Hsu and Perrimon, 1994) Dsor1 and phl both play a role in the determination of the rate of proliferation. Maternally derived Dsor1 is required for development of the embryonic termini. Dsor1 is involved in both the positive and negative regulation of tll. (Tsuda et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078543 RefSeq (Proteins) • NP_511098 DDBJ / EMBL / GenBank • AAF46475 AAL13921 AAN17587 AAN17588 AAN17589 AAN17590 AAN17591 AAN17592 AAN17593 AAN17594 AAN17595 AAN17596 AAN17597 AAN17598 AAN17599 AAN17600 AAN17601 AAN17602 AAN17603 AAN17604 AAN17605 AI514711 AJ569103 AJ569104 AJ569106 AJ569107 AJ569108 AJ569109 AJ569110 AJ569111 AJ569112 AJ569113 AJ569114 AJ569115 AJ569117 AJ569118 AJ569119 AJ569120 AJ569121 AJ569122 AJ569123 AJ569124 AJ569125 AJ569126 AJ569128 AJ569129 AY058692 AY135075 AY135076 AY135077 AY135078 AY135079 AY135080 AY135081 AY135082 AY135083 AY135084 AY135085 AY135086 AY135087 AY135088 AY135089 AY135090 AY135091 AY135092 AY135093 BAA02925 D13782 Entrez Gene - A searchable database of RefSeq genes. • 31872 UniProtKB/Swiss-Prot • Q24324
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD41207
Linkouts
	BioGRID - A database of protein and genetic interactions • 58322 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010269 DroID - A comprehensive database of gene and protein interactions. • FBgn0010269 DRSC - Results from RNAi screens. • FBgn0010269 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010269 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15793-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31872 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31872 modMine - Data generated by the modENCODE project. • FBgn0010269 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24324
Synonyms & Secondary IDs ( 40 )
Reported As
Symbol Synonym	CG15793 (Morrison et al., 2000, Mouchel-Vielh et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) Dmek (Mantrova and Hsu, 1998) D-MEK (Hermon et al., 1998) D-Mek (Perrimon et al., 1995) D-mek (Morisato and Anderson, 1995, Hsu and Perrimon, 1994, Lu et al., 1994) dMEK (Lee et al., 2002, Kim et al., 2004) DMEK-1 (Duffy and Perrimon, 1994) D-MEK/Dsor (Baek and Lee, 1999) DRODSOR1 (Fernando Vazquez et al., 2000, Lopez et al., 1999, Schug et al., 1997) Dsor (Read et al., 2005, Kockel et al., 2001, Baker et al., 2002, Borland et al., 2001, Roman and Davis, 2001, Li et al., 2000, Jimenez et al., 2000, Meier and Evan, 1998, Kurada and White, 1998, Tang et al., 1997, Cagan, 1993, Guichard et al., 2006, Harrison et al., 2005, Bianco et al., 2007, Legent et al., 2008, Cinnamon et al., 2008, Guichard et al., 2006, Helman et al., 2011) D-SOR (Martin-Blanco, 2000) D-sor (Janody et al., 2000) DSor (Ip and Davis, 1998, Therrien et al., 1995) dSor (Lee et al., 2002) D-Sor (Sackton et al., 2007) DSor1 (Wilson et al., 2005) DSOR1 (Clemens et al., 2000, Raabe, 2000) dsor1 (Moodie and Wolfman, 1994) D-sor-1 (Perrimon and Desplan, 1994) Dsor1 (Lim et al., 1997, Nishimura et al., 2007, Legent et al., 2012, Michellod et al., 2003, Walker et al., 2006, Christensen et al., 2008.6.11, Christensen et al., 2008.6.11, Dawes-Hoang and Wieschaus, 2001, Ragab et al., 2011, Christensen et al., 2008.12.28, Mogila et al., 2006, Nishimura et al., 2007, Xia et al., 2008, Mouchel-Vielh et al., 2008, Oishi et al., 2006, Hill-Burns and Clark, 2009, Guichard et al., 2006, Sims et al., 2009, Zhou et al., 2008, Maher et al., 2011, Friedman et al., 2011, Zeng et al., 2010, Gomez et al., 2012) dSor1 (Majumdar et al., 2010) DSORT (Claeys et al., 2002) EK1-1 (Therrien et al., 2000) MAPKK (Kumar and Moses, 2000, Marshall, 1994, Yoneda et al., 2007, Bianco et al., 2007, Dawes-Hoang and Wieschaus, 2001, Herr et al., 2010) MEK (Douziech et al., 2003, Rebay, 2002, Castelli-Gair Hombria and Brown, 2002, Roy and Therrien, 2002, Anselmo et al., 2002, Yokokura et al., 2002, Roy et al., 2002, Kumar and Moses, 2001, Kumar and Moses, 2001, Morrison et al., 2000, Perrimon and Duffy, 1998, Duffy et al., 1998, Lu and Li, 1998, Karim and Rubin, 1998, Karim et al., 1997, Badenhorst et al., 1996, Klaembt et al., 1996, Avruch et al., 1994, Mogila and Li, 2006, Douziech et al., 2006, Ashton-Beaucage and Therrien, 2007, Mogila et al., 2007, Vrailas et al., 2006, Kim et al., 2006, Walker et al., 2006, Harrison et al., 2005, Mogila et al., 2006, Mouchel-Vielh et al., 2008, Nie et al., 2009, Herr et al., 2010, Roignant and Treisman, 2010, Tipping et al., 2010, Majumdar et al., 2010) mek (Therrien et al., 2000, Ashton-Beaucage et al., 2010, Liu et al., 2010) Mek (Kumar and Moses, 2000) MEK1/2 (Ivanovska et al., 2004) MEK/Dsor1 (Friedman and Perrimon, 2006) SOR (Morrison et al., 2000) sor (Morrison et al., 2000) Sor (Kim et al., 2006) sor/MEK1 (Wilson et al., 2001) Su(Raf)34B (Zhang et al., 1999)
Name Synonym	Downstream of raf1 (Legent et al., 2012, Oishi et al., 2006) downstream suppressor of Raf 1 (Xia et al., 2008) Drosophila MEK (Mogila et al., 2007) Map kinase kinase (Harrison et al., 2005) MAP Kinase Kinase (Majumdar et al., 2010) MAPK kinase (Bianco et al., 2007)
Secondary FlyBase IDs
References ( 193 )
Generate a list of	All references relating to this gene ( 193 )
List References by type	Research paper  ( 100 ) Supplementary material  ( 7 ) Review  ( 44 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 21 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 8 )
	Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Gomez et al., 2012, J. Cell Biol. 199(7): 1131--1143 Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. [FBrf0220436] Legent et al., 2012, Genetics 190(2): 601--616 A screen for x-linked mutations affecting Drosophila photoreceptor differentiation identifies casein kinase 1α as an essential negative regulator of wingless signaling. [FBrf0217484] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Helman et al., 2011, Curr. Biol. 21(13): 1102--1110 Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. [FBrf0214255] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270 ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618] Ragab et al., 2011, EMBO J. 30(6): 1123--1136 Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells. [FBrf0213275] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...