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Gene Dmel\Dsor1

General Information
Symbol	Dmel\Dsor1	Species	D. melanogaster
Name	Downstream of raf1	Annotation symbol	CG15793
Feature type	protein_coding_gene	FlyBase ID	FBgn0010269
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	MEK, Dsor, MAPKK, D-MEK, DRODSOR1, SOR, D-SOR, Dmek
Genomic Location
Chromosome (arm)	X	Recombination map	1-27.6
Cytogenetic map	8D2-8D3	Sequence location	X:9,141,375..9,144,070 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Downstream of raf1 is referred to in FlyBase by the symbol Dmel\Dsor1 (CG15793, FBgn0010269). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: MAP kinase kinase activity. There is experimental evidence that it is involved in the biological process: terminal region determination; border follicle cell migration; hemocyte differentiation; signal transduction. 40 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; nervous system; adult segment; adult mesothoracic segment; germarium; egg; primordium; histaminergic neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1626006_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dsor1. Gene sequence location is X:9141375..9144070.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms terminal region determination Sequence features BKN50832 BKN50551 BKN22342 HFA18462 References Majumdar et al., 2010, Fly 4(3): 204--212
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8D2-8D3   Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912
Experimentally Determined Cytological Location
Cytogenetic map Notes References 8D-8D     (Nishida, 1992.11.27) 8D-8D   (determined by in situ hybridisation)   (Tsuda et al., 1993)
Experimentally Determined Recombination Data
Location	1-27.6 (Nishida, 1992.11.27)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dsor1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dsor1-RA FBtr0071313  NM_078543   1799   396
Additional Transcript Data & Comments
Reported size (kB)	2.0 (northern blot) (Tsuda et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dsor1-PA   FBpp0071248   43.9   396   6.25     NP_511098   AAF46475
Additional Polypeptide Data & Comments
Reported size (kDa)	393 (aa); 44 (kD) (Tsuda et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246723   AE014298 AAF46475   AI514711   AJ569103   AJ569104   AJ569106   AJ569107   AJ569108   AJ569109   AJ569110   AJ569111   AJ569112   AJ569113   AJ569114   AJ569115   AJ569117   AJ569118   AJ569119   AJ569120   AJ569121   AJ569122   AJ569123   AJ569124   AJ569125   AJ569126   AJ569128   AJ569129   AY058692 AAL13921   AY135075 AAN17587   AY135076 AAN17588   AY135077 AAN17589   AY135078 AAN17590   AY135079 AAN17591   AY135080 AAN17592   AY135081 AAN17593   AY135082 AAN17594   AY135083 AAN17595   AY135084 AAN17596   AY135085 AAN17597   AY135086 AAN17598   AY135087 AAN17599   AY135088 AAN17600   AY135089 AAN17601   AY135090 AAN17602   AY135091 AAN17603   AY135092 AAN17604   AY135093 AAN17605   CA806639   CO287807   D13782 BAA02925   EC051294   EC052375   EC053844   EC055023   EC055040   EC055338   EC055890   EC056072   EC056208   EC056305   EC059103   EC059529   EC081470   EV578441   GH974496   GH981145   HM449888
UniProtKB/Swiss-Prot	Q24324
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Tsuda et al., 1993)
Additional Descriptive Data
	Dsor1 transcripts are expressed throughout development and are particularly abundant in early embryos. (Tsuda et al., 1993)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010269    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010269 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010269 expression level Developmental Stage   Expression Level embryo 00-02hr    5893 embryo 02-04hr    2289 embryo 04-06hr    3069 embryo 06-08hr    1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1588 white prepupae new    1696 white prepupae 12hr    2122 white prepupae 24hr    2916 pupae 2d postWPP    1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day    2299 adult female 05day    3571 adult female 30day    3805 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5893) embryo 02-04hr  (2289) embryo 04-06hr  (3069) embryo 06-08hr  (1542) embryo 08-10hr  (1190) embryo 10-12hr  (1178) embryo 12-14hr  (776) embryo 14-16hr  (853) embryo 16-18hr  (615) embryo 18-20hr  (565) embryo 20-22hr  (470) embryo 22-24hr  (472) larva L1  (847) larva L2  (892) larva L3 12hr old  (845) larva L3 puffstage 1-2  (1118) larva L3 puffstage 3-6  (1432) larva L3 puffstage 7-9  (1588) white prepupae new  (1696) white prepupae 12hr  (2122) white prepupae 24hr  (2916) pupae 2d postWPP  (1620) pupae 3d postWPP  (679) pupae 4d postWPP  (632) adult male 01day  (869) adult male 05day  (910) adult male 30day  (878) adult female 01day  (2299) adult female 05day  (3571) adult female 30day  (3805) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5893) embryo 02-04hr  (2289) embryo 04-06hr  (3069) embryo 06-08hr  (1542) embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6  1432 larva L3 puffstage 7-9  (1588) white prepupae new  (1696) white prepupae 12hr  (2122) white prepupae 24hr  (2916) pupae 2d postWPP  (1620) pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day  (2299) adult female 05day  (3571) adult female 30day  (3805) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5893 embryo 02-04hr    2289 embryo 04-06hr    3069 embryo 06-08hr    1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1588 white prepupae new    1696 white prepupae 12hr    2122 white prepupae 24hr    2916 pupae 2d postWPP    1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day    2299 adult female 05day    3571 adult female 30day    3805 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5893 embryo 02-04hr    2289 embryo 04-06hr    3069 embryo 06-08hr    1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1588 white prepupae new    1696 white prepupae 12hr    2122 white prepupae 24hr    2916 pupae 2d postWPP    1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day    2299 adult female 05day    3571 adult female 30day    3805 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010269 expression level Developmental Stage   Expression Level embryo 00-02hr    5893 embryo 02-04hr    2289 embryo 04-06hr    3069 embryo 06-08hr    1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1588 white prepupae new    1696 white prepupae 12hr    2122 white prepupae 24hr    2916 pupae 2d postWPP    1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day    2299 adult female 05day    3571 adult female 30day    3805 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5893) embryo 02-04hr  (2289) embryo 04-06hr  (3069) embryo 06-08hr  (1542) embryo 08-10hr  (1190) embryo 10-12hr  (1178) embryo 12-14hr  (776) embryo 14-16hr  (853) embryo 16-18hr  (615) embryo 18-20hr  (565) embryo 20-22hr  (470) embryo 22-24hr  (472) larva L1  (847) larva L2  (892) larva L3 12hr old  (845) larva L3 puffstage 1-2  (1118) larva L3 puffstage 3-6  (1432) larva L3 puffstage 7-9  (1588) white prepupae new  (1696) white prepupae 12hr  (2122) white prepupae 24hr  (2916) pupae 2d postWPP  (1620) pupae 3d postWPP  (679) pupae 4d postWPP  (632) adult male 01day  (869) adult male 05day  (910) adult male 30day  (878) adult female 01day  (2299) adult female 05day  (3571) adult female 30day  (3805) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5893) embryo 02-04hr  2289 embryo 04-06hr  (3069) embryo 06-08hr  1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6  1432 larva L3 puffstage 7-9  1588 white prepupae new  1696 white prepupae 12hr  2122 white prepupae 24hr  (2916) pupae 2d postWPP  1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day  2299 adult female 05day  (3571) adult female 30day  (3805) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5893 embryo 02-04hr    2289 embryo 04-06hr    3069 embryo 06-08hr    1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1588 white prepupae new    1696 white prepupae 12hr    2122 white prepupae 24hr    2916 pupae 2d postWPP    1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day    2299 adult female 05day    3571 adult female 30day    3805 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5893 embryo 02-04hr    2289 embryo 04-06hr    3069 embryo 06-08hr    1542 embryo 08-10hr    1190 embryo 10-12hr    1178 embryo 12-14hr    776 embryo 14-16hr    853 embryo 16-18hr    615 embryo 18-20hr    565 embryo 20-22hr    470 embryo 22-24hr    472 larva L1    847 larva L2    892 larva L3 12hr old    845 larva L3 puffstage 1-2    1118 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1588 white prepupae new    1696 white prepupae 12hr    2122 white prepupae 24hr    2916 pupae 2d postWPP    1620 pupae 3d postWPP    679 pupae 4d postWPP    632 adult male 01day    869 adult male 05day    910 adult male 30day    878 adult female 01day    2299 adult female 05day    3571 adult female 30day    3805 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010269    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010269 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010269 expression level Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010269 expression level Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    189.675 Larval Midgut    94.3 Larval Hindgut    125.2 Larval Malpighian Tubules    136.1 Larval Fat Body    61.7 Larval Salivary Gland    116.2 Larval Trachea    90.875 Larval Carcass    96.875 Adult Head    83.9 Adult Eye    77.125 Adult Brain    215.1 Adult Thoracic-Abdominal Ganglion    179.7 Adult Crop    73.2 Adult Midgut    66.7 Adult Hindgut    104.1 Adult Malpighian Tubules    118.6 Adult Fat Body    56.6 Adult Salivary Gland    130 Adult Heart    80.375 Adult VirginFemale Spermatheca    75.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    213.8 Adult Testis no informative data Adult Male Accessory Gland    104.9 Adult Carcass    77.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    83.9   NA  Eye    77.125   NA  Brain    215.1   189.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    179.7   NA  Crop    73.2   94.3  Midgut    66.7   125.2  Hindgut    104.1   136.1  Malpighian Tubules    118.6   61.7  Fat Body    56.6   116.2  Salivary Gland    130   NA  Heart    80.375   90.875  Trachea    NA   NA  VirginFemale Spermatheca    75.9   NA  InseminatedFemale Spermatheca    73   NA  Ovary    213.8   NA  Testis    no informative data   NA  Male Accessory Gland    104.9   96.875  Carcass    77.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010269 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15793-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Dsor1LH110 lethal | adult stage | recessive Dsor1XS520 lethal | embryonic stage | recessive Dsor1LH110 lethal | polyphasic Dsor1LH110 lethal | pupal stage, with Scer\GAL4pnr-MD237 Dsor1GD9123 lethal | recessive Dsor1756 Dsor1r1 Dsor1r2 Dsor1S-1221 Dsor1unspecified Other Phenotypes Allele neuroanatomy defective | embryonic stage Dsor1LH110 visible Dsor1XS520 visible, with Scer\GAL4pnr-MD237 Dsor1GD9123 visible | dominant Dsor1XS520 visible | recessive Dsor1XS520 wild-type Dsor1+t9 Phenotype manifest in Allele chorion | maternal effect | somatic clone Dsor1756 dorsal appendage Dsor1ts1 egg chamber | maternal effect | somatic clone Dsor1756 embryonic dorsal epidermis Dsor1LH110 eye Dsor1LF133 Dsor1Su1 Dsor1XS520 eye photoreceptor cell Dsor1XS520 germarium, with Scer\GAL4unspecified Dsor1VDRC.cUa imaginal disc | somatic clone Dsor1Gp158 Dsor1r1 intermediate ventral neurectoderm Dsor1LH110 mesothoracic tergum, with Scer\GAL4pnr-MD237 Dsor1GD9123 ommatidium Dsor1Su1 Dsor1Su12 Dsor1Su18 Dsor1Su24 Dsor1Su4 Dsor1Su6 Dsor1Su7 Dsor1XS520 photoreceptor cell R1 Dsor1XS520 photoreceptor cell R2 Dsor1XS520 photoreceptor cell R3 Dsor1XS520 photoreceptor cell R4 Dsor1XS520 photoreceptor cell R5 Dsor1XS520 photoreceptor cell R6 Dsor1XS520 photoreceptor cell R7 Dsor1Su1 Dsor1Su12 Dsor1Su4 Dsor1Su6 Dsor1Su7 Dsor1XS520 Dsor1ts1 pigment cell Dsor1Su1 spectrosome | supernumerary, with Scer\GAL4unspecified Dsor1VDRC.cUa wing vein Dsor1XS520
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of Dsor1 Class Mutagen Stocks Known lesion Dsor1LH110 amorphic allele - genetic evidence, loss of function allele 1 -- Dsor1G42 ethyl methanesulfonate 1 -- Dsor1G79 ethyl methanesulfonate 1 -- Dsor1G9740 P-element activity 1 -- Dsor1S-1221 ethyl methanesulfonate 1 -- Dsor11 0 -- Dsor1756 ethyl methanesulfonate 0 -- Dsor1Gp158 Delta2-3 0 Yes Dsor1LF133 0 -- Dsor1MAPKK 0 -- Dsor1r1 ethyl methanesulfonate 0 -- Dsor1r2 ethyl methanesulfonate 0 -- Dsor1Su12 0 Yes Dsor1Su18 0 Yes Dsor1Su1 gain of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dsor1Su24 0 Yes Dsor1Su34B ethyl methanesulfonate 0 Yes Dsor1Su4 0 Yes Dsor1Su5 0 Yes Dsor1Su6 0 Yes Dsor1Su7 0 Yes Dsor1unspecified 0 -- Dsor1XS520 hypomorphic allele - genetic evidence X ray 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dsor1 Class Mutagen Stocks Known lesion Dsor1GD9123 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dsor1GL00096 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1GLV21003 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1HMS00037 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1HMS00145 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1HMS00710 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1JF01697 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1JF03100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1KK102276 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsor1+t9 in vitro construct - genomic fragment 0 Yes Dsor12E.MtnA.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes Dsor1D83V in vitro construct - amino acid replacement 0 Yes Dsor1DA.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Dsor1dsRNA.cCa in vitro construct - RNAi 0 Yes Dsor1ts1 in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Dsor1ts2 in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Dsor1VDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)10-70d (Santamaria and Randsholt, 1995) Df(1)BSC537 (Christensen et al., 2008.6.11) Df(1)BSC538 (Christensen et al., 2008.6.11) Df(1)BSC663 (Christensen et al., 2008.12.28) Df(1)Exel9049 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9123} NA P{KK102276} NA P{TRiP.GL00096} NA P{TRiP.GLV21003} NA P{TRiP.HMS00037} NA P{TRiP.HMS00145} NA P{TRiP.HMS00710} NA P{TRiP.JF01697} NA P{TRiP.JF03100} NA characterization construct P{D-mekD83V} NA P{D-mekts1} NA P{D-mekts2} NA P{D-mekwt-20J} NA P{VDRC.Dsor1.U} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Dsor1Gp158 NA insertion of mobile activating element P{EP}Dsor1G9740 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
border follicle cell migration inferred from genetic interaction with sl (Bianco et al., 2007) hemocyte differentiation inferred from genetic interaction with hop (Luo et al., 2002) signal transduction inferred from genetic interaction with phl (Tsuda et al., 1993) inferred from mutant phenotype (Hsu and Perrimon, 1994) terminal region determination inferred from mutant phenotype (Jimenez et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) MAP kinase activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) MAP kinase kinase activity inferred from sequence or structural similarity (Noselli and Glise, 1996, Lim et al., 1997) non-traceable author statement (Nishida, 1992.11.27) traceable author statement (Martin-Blanco, 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) receptor signaling protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
anterior/posterior axis specification, embryo traceable author statement (Baek and Lee, 1999) epidermal growth factor receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) MAPKKK cascade non-traceable author statement (Martin-Blanco, 2000) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) traceable author statement (Kumar and Moses, 2000) regulation of Toll signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) sevenless signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) torso signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dsor1 allele Gene References Dsor1+t9 phl (Hsu and Perrimon, 1994) Dsor1Gp158 aos (Sawamoto et al., 1996) rl (Lim et al., 1999) Dsor1LF133 svp (Kramer et al., 1995) W (Kurada and White, 1998) Dsor1LH110 Src42A (Lu et al., 1994) Su(phl)4 (Lu et al., 1994) Su(phl)6 (Lu et al., 1994) Su(phl)7 (Lu et al., 1994) Su(phl)9 (Lu et al., 1994) Su(phl)43B (Lu et al., 1994) Dsor1r1 phl (Li et al., 2000) rl (Lim et al., 1999) Src42A (Takahashi et al., 1996) tor (Li and Li, 2003) Dsor1r2 if (Baker et al., 2002) Dsor1S-1221 aop (Karim et al., 1996) hop (Luo et al., 2002) Ras85D (Karim et al., 1996) Dsor1Su1 aos (Sawamoto et al., 1996) asp (Inoue and Glover, 1998) cln (Taguchi et al., 2000) csw (Tsuda et al., 1993) Egfr (Lim et al., 1997) fs(1)M3 (Lim et al., 1999) lace (Adachi-Yamada et al., 1999) N (Nagaraj et al., 1999) phl (Tsuda et al., 1993, Lim et al., 1997) rpr (Kurada and White, 1998) sev (Lim et al., 1997) Sos (Lim et al., 1997, Taguchi et al., 2000) tor (Lim et al., 1997, Lim et al., 1999) W (Sawamoto et al., 1998, Kurada and White, 1998) Dsor1Su4 Egfr (Lim et al., 1997) Sos (Lim et al., 1997) Dsor1Su7 Sos (Lim et al., 1997) Dsor1Su12 phl (Lim et al., 1997) sev (Lim et al., 1997) tor (Lim et al., 1997) Dsor1Su18 phl (Lim et al., 1997) sev (Lim et al., 1997) Sos (Lim et al., 1997) tor (Lim et al., 1997) Dsor1Su24 phl (Lim et al., 1997) sev (Lim et al., 1997) Sos (Lim et al., 1997) tor (Lim et al., 1997) Dsor1Su34B Egfr (Zhang et al., 1999) phl (Lu et al., 1994, Zhang et al., 1999) rl (Zhang et al., 1999) sag (Zhang et al., 1999) Su(SuRaf1)IV (Zhang et al., 1999) Dsor1unspecified ksr::tor (Therrien et al., 2000) Ras85D (Therrien et al., 2000) Dsor1XS520 aop (Karim et al., 1996) ER2-1 (Karim et al., 1996) ER2-3 (Karim et al., 1996) ER2-4 (Karim et al., 1996) ER2-7B (Karim et al., 1996) ER3-2 (Karim et al., 1996) ER3-4 (Karim et al., 1996) hh (Karim et al., 1996) hop (Luo et al., 2002) ksr (Karim et al., 1996) mam (Karim et al., 1996) mts (Karim et al., 1996) pnt (O'Neill et al., 1994) PTP-ER (Karim et al., 1996, Karim and Rubin, 1999) Ras85D (Karim et al., 1996) rl (Karim et al., 1996) SR3-6 (Karim et al., 1996) Src42A (Lu and Li, 1999) Taf6 (Karim et al., 1996) unspecified 14-3-3ε (Karim et al., 1996) ebi (Tsuda et al., 1997) Gef26 (Lee et al., 2002) ksr (Therrien et al., 2000) phl (Lim et al., 1997) Ras85D (O'Neill et al., 1994) S6kII (Kim et al., 2006) sev (Lim et al., 1997) tor (Lim et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58322 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010269 DroID - A comprehensive database of gene and protein interactions. • FBgn0010269 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31872
Orthologs
Genome-wide drosophilid orthologs	Dana\Dsor1 Dere\GG18305 Dgri\GH12793 Dmoj\GI15238 Dper\GL16493 Dpse\GA13960 Dsec\GM22414 Dsim\Dsor1 Dvir\GJ18839 Dwil\GK25111 Dyak\GE17784
Curated drosophilid orthologs	Dana\Dsor1   Dpai\Dsor1   Dpse\GA13960   Dsim\Dsor1
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012723-PA Aedes aegypti (mosquito) AGAP001103-PA Anopheles gambiae (mosquito) XP_001948295.1 Acyrthosiphon pisum (pea aphid) At4g29810.1 Arabidopsis thaliana (wall cress) 2915 Batrachochytrium dendrobatidis (chytrid fungus) 124326 Branchiostoma floridae (lancelet) BGIBMGA001458-PA Bombyx mori (silk worm) ENSBTAP00000045293 Bos taurus (bovine) CAL0004814 Candida albicans (a form of yeast) CBP01107 Caenorhabditis briggsae (nematode) CE25437 Caenorhabditis elegans (worm) ENSCAFP00000025491 Canis familiaris (dog) CAGL0I03498g Candida glabrata (haploid yeast) Chro.80584 Cryptosporidium hominis (obligate parasite) ENSCINP00000008465 Ciona intestinalis (sea squirt) JA00602 Caenorhabditis japonica (nematode) cn03495 Cryptococcus neoformans (yeast-like fungus) cgd8_5120 Cryptosporidium parvum (protozoan parasite) CPIJ015801 Culex pipens (mosquito) ENSCPOP00000002764 Cavia porcellus (guinea pig) 155835 Chlamidomonas reinhardtii (green alga) RP29622 Caenorhabditis remanei (nematode) ENSCSAVP00000014411 Ciona savignyi (sedentary tunicate) 21500 Capitella spl (polychaete worm) DDB0191164 Dictyostelium discoideum (amoeba) DEHA2F14498g Debaryomyces Hansenii (yeast) 46211 Daphnia pulex (daphnia) ENSDARP00000014914 Danio rerio (zebra fish) ENSECAP00000008990 Equus caballus (horse) ENSGACP00000016808 Gymnopilus aculeatus (mushroom) ENSGALP00000012448 Gallus gallus (chicken) GL50803_22165 Giardia lamblia (flagellated protozoan) 155691 Hypsipyla robusta (cedar shoot borer) ENSP00000302486 Homo sapiens (human) ISCW005428-PA Ixodes scapularis (deer tick) KLLA0C16577g Kluyveromyces lactis (yeast) 132393 Lottia gigantea (owl limpet) LmjF36.0860 Leishmania major (virus) 18821 Monocosta brevicollis (choanoflagellate) ENSMODP00000012146 Monodelphis domestica (gray opossum) ENSMMUP00000022140 Macaca mulatta (rhesus monkey) ENSMUSP00000005066 Mus musculus (house mouse) 91949 Nematostella vectensis (starlet anemone) ENSOANP00000015470 Ornithorynchus anatinus (platypus) ENSORLP00000006223 Oryzias latipes (japanese killifish) LOC_Os01g32660.1 Oryza sativa (asian rice) 16878 Ostreococcus tauri (green alga) PHUM004534-PA Pediculus humanus (human body louse) PP07162 Pristionchus pacificus (nematode) 206232 Physcomitrella patens (moss) ENSPPYP00000007458 Pongo pygmaeus (orangutan) 80373 Phytophthora ramorum (sudden oak death pathogen) 142783 Phytophthora sojae (root rot pathogen) 745168 Populus trichocarpa (black cottonwood) ENSPTRP00000012302 Pan troglodytes (chimpanzee) ENSRNOP00000013933 Rattus norvegicus (norway rat) 4753151 Sorghum bicolor (sorghum) YOR231W Saccharomyces cerevisiae (budding yeast) Smp_026510 Schistosoma mansoni (trematode parasite) SPAC1D4.13 Schizosaccharomyces pombe (fission yeast) XP_781505.2 Strongylocentrotus purpuratus (purple sea urchin) 54589 Trichoplax adhaerens (metazoa) XP_973216.2 Tribolium castaneum (red flour beetle) Tc00.1047053506679.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000011262 Tetraodon nigroviridis (green spotted pufferfish) 263979 Thalassiosira pseudonana (marine diatom) ENSTRUP00000045843 Takifugu rubripes (pufferfish Takifugu) 151.m00090 Tetrahymena thermophila (ciliate protozoa) 92406.m00150 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000034662 Xenopus tropicalis (frog) YALI0B13178g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14827 NV21219 LH13340 ISCW005428 FBgn0235228 FBgn0227070 FBgn0205985 FBgn0063994 FBgn0177284 JGI_V11_46211 FBgn0073992 FBgn0154097 FBgn0137987 FBgn0120272 FBgn0110521 FBgn0082825 CPIJ015801 BGIBMGA001458 ACYPI000770 GB13922 AGAP001103 AAEL012723 PHUM413460 GLEAN_04803
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	33284 w* P{EP}Dsor1G9740 28685 y1 v1; P{TRiP.JF03100}attP2 31184 y1 v1; P{TRiP.JF01697}attP2 33639 y1 v1; P{TRiP.HMS00037}attP2 8496 y1 wa Dsor1S-1221/Basc 7136 w1 Dsor1G79/FM7c/Dp(1;Y)FF1, y+ 7131 y1 ac1 z1 Dsor1G42/FM7a 34830 y1 sc* v1; P{TRiP.HMS00145}attP2 36099 y1 sc* v1; P{TRiP.GLV21003}attP2
VDRC	v107276 P{KK102276}VIE-260B v40026 w1118; P{GD9123}v40026 v40025 w1118; P{GD9123}v40025/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR30C13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD41207
Other clones	DPiM_LD41207
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD05838
Other clones	CK01.84A.C12 CK01.98B.E7 CK01.118A.D5 Dmel_dig_017906_0680_2891 EC051294 EC052375 EC053844 EC055023 EC055040 EC055338 EC055890 EC056072 EC056208 EC056305 EK066844 ESG014b.E21_D07 RP004235055 RP004362344
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31872
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Wild-type Dsor1 does not complement the mating defect of S.cerevisiae Scer\ste7 mutants. A mutated form of Dsor1 (carrying the lesion found in Dsor1Su1) does complement the mating defect of S.cerevisiae Scer\ste7 mutants. Wild-type Dsor1 does not complement the temperature-sensitive cell-lysis defect of S.cerevisiae Scer\MKK1 Scer\MKK2 double mutants. A mutated form of Dsor1 (carrying the lesion found in Dsor1Su1) does complement the temperature-sensitive cell-lysis defect of S.cerevisiae Scer\MKK1 Scer\MKK2 double mutants. Wild-type Dsor1 or a mutated form of Dsor1 (carrying the lesion found in Dsor1Su1) does not complement the sensitivity to osmotic pressure of S.cerevisiae Scer\pbs2 mutants. (Lim et al., 1997)
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Douziech et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The MAPK cascade is required for Ras85D mitogenic response, loss of function mutations in phl, Dsor1, rl and ksr dominantly suppress hyperplastic growth, as do mutations in the Ras85D effector loop that disrupt the Ras85D-phl interaction. (Karim and Rubin, 1998) Downstream signal transducer of torso, sevenless and DER receptors. (Noselli and Glise, 1996) Studies of interaction between argos and members of the Ras/MAPK pathway demonstrate the argos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade. (Sawamoto et al., 1996) Expression of Dsor1 in lin-3, let-23 or lin-45 C.elegans mutants permits P5.p, P6.p and P7.p segments to adopt the vulval fates in each of the vulvaless backgrounds. (Koga and Ohshima, 1995) Additional alleles of Dsor1 have been isolated in screen for lethal mutations that fail to complement Df(1)10-70d. (Santamaria and Randsholt, 1995) A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl. (Therrien et al., 1995) Down-regulation of bcd activity depends on the function of Dsor1. Dsor1 acts downstream of phl in the tor pathway and encodes a MAP-kinase kinase (MAPKK). Several clustered consensus sites for MAP kinase phosphorylation can be found in the bcd coding sequence. (Dostatni et al., 1994) Dsor1 acts downstream of phl in the DER pathway. (Hsu and Perrimon, 1994) Dsor1 and phl both play a role in the determination of the rate of proliferation. Maternally derived Dsor1 is required for development of the embryonic termini. Dsor1 is involved in both the positive and negative regulation of tll. (Tsuda et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078543 RefSeq (Proteins) • NP_511098 DDBJ / EMBL / GenBank • AAF46475 AAL13921 AAN17587 AAN17588 AAN17589 AAN17590 AAN17591 AAN17592 AAN17593 AAN17594 AAN17595 AAN17596 AAN17597 AAN17598 AAN17599 AAN17600 AAN17601 AAN17602 AAN17603 AAN17604 AAN17605 AI514711 AJ569103 AJ569104 AJ569106 AJ569107 AJ569108 AJ569109 AJ569110 AJ569111 AJ569112 AJ569113 AJ569114 AJ569115 AJ569117 AJ569118 AJ569119 AJ569120 AJ569121 AJ569122 AJ569123 AJ569124 AJ569125 AJ569126 AJ569128 AJ569129 AY058692 AY135075 AY135076 AY135077 AY135078 AY135079 AY135080 AY135081 AY135082 AY135083 AY135084 AY135085 AY135086 AY135087 AY135088 AY135089 AY135090 AY135091 AY135092 AY135093 BAA02925 D13782 Entrez Gene - A searchable database of RefSeq genes. • 31872 UniProtKB/Swiss-Prot • Q24324
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58322 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010269 DroID - A comprehensive database of gene and protein interactions. • FBgn0010269 DRSC - Results from RNAi screens. • FBgn0010269 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010269 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15793-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31872 InParanoid A subset of ortholog calls from InParanoid. • AAEL012723-PA Aedes aegypti (mosquito) AGAP001103-PA Anopheles gambiae (mosquito) XP_001948295.1 Acyrthosiphon pisum (pea aphid) At4g29810.1 Arabidopsis thaliana (wall cress) 2915 Batrachochytrium dendrobatidis (chytrid fungus) 124326 Branchiostoma floridae (lancelet) BGIBMGA001458-PA Bombyx mori (silk worm) ENSBTAP00000045293 Bos taurus (bovine) CAL0004814 Candida albicans (a form of yeast) CBP01107 Caenorhabditis briggsae (nematode) CE25437 Caenorhabditis elegans (worm) ENSCAFP00000025491 Canis familiaris (dog) CAGL0I03498g Candida glabrata (haploid yeast) Chro.80584 Cryptosporidium hominis (obligate parasite) ENSCINP00000008465 Ciona intestinalis (sea squirt) JA00602 Caenorhabditis japonica (nematode) cn03495 Cryptococcus neoformans (yeast-like fungus) cgd8_5120 Cryptosporidium parvum (protozoan parasite) CPIJ015801 Culex pipens (mosquito) ENSCPOP00000002764 Cavia porcellus (guinea pig) 155835 Chlamidomonas reinhardtii (green alga) RP29622 Caenorhabditis remanei (nematode) ENSCSAVP00000014411 Ciona savignyi (sedentary tunicate) 21500 Capitella spl (polychaete worm) DDB0191164 Dictyostelium discoideum (amoeba) DEHA2F14498g Debaryomyces Hansenii (yeast) 46211 Daphnia pulex (daphnia) ENSDARP00000014914 Danio rerio (zebra fish) ENSECAP00000008990 Equus caballus (horse) ENSGACP00000016808 Gymnopilus aculeatus (mushroom) ENSGALP00000012448 Gallus gallus (chicken) GL50803_22165 Giardia lamblia (flagellated protozoan) 155691 Hypsipyla robusta (cedar shoot borer) ENSP00000302486 Homo sapiens (human) ISCW005428-PA Ixodes scapularis (deer tick) KLLA0C16577g Kluyveromyces lactis (yeast) 132393 Lottia gigantea (owl limpet) LmjF36.0860 Leishmania major (virus) 18821 Monocosta brevicollis (choanoflagellate) ENSMODP00000012146 Monodelphis domestica (gray opossum) ENSMMUP00000022140 Macaca mulatta (rhesus monkey) ENSMUSP00000005066 Mus musculus (house mouse) 91949 Nematostella vectensis (starlet anemone) ENSOANP00000015470 Ornithorynchus anatinus (platypus) ENSORLP00000006223 Oryzias latipes (japanese killifish) LOC_Os01g32660.1 Oryza sativa (asian rice) 16878 Ostreococcus tauri (green alga) PHUM004534-PA Pediculus humanus (human body louse) PP07162 Pristionchus pacificus (nematode) 206232 Physcomitrella patens (moss) ENSPPYP00000007458 Pongo pygmaeus (orangutan) 80373 Phytophthora ramorum (sudden oak death pathogen) 142783 Phytophthora sojae (root rot pathogen) 745168 Populus trichocarpa (black cottonwood) ENSPTRP00000012302 Pan troglodytes (chimpanzee) ENSRNOP00000013933 Rattus norvegicus (norway rat) 4753151 Sorghum bicolor (sorghum) YOR231W Saccharomyces cerevisiae (budding yeast) Smp_026510 Schistosoma mansoni (trematode parasite) SPAC1D4.13 Schizosaccharomyces pombe (fission yeast) XP_781505.2 Strongylocentrotus purpuratus (purple sea urchin) 54589 Trichoplax adhaerens (metazoa) XP_973216.2 Tribolium castaneum (red flour beetle) Tc00.1047053506679.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000011262 Tetraodon nigroviridis (green spotted pufferfish) 263979 Thalassiosira pseudonana (marine diatom) ENSTRUP00000045843 Takifugu rubripes (pufferfish Takifugu) 151.m00090 Tetrahymena thermophila (ciliate protozoa) 92406.m00150 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000034662 Xenopus tropicalis (frog) YALI0B13178g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31872 modMine - Data generated by the modENCODE project. • FBgn0010269 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14827 NV21219 LH13340 ISCW005428 FBgn0235228 FBgn0227070 FBgn0205985 FBgn0063994 FBgn0177284 JGI_V11_46211 FBgn0073992 FBgn0154097 FBgn0137987 FBgn0120272 FBgn0110521 FBgn0082825 CPIJ015801 BGIBMGA001458 ACYPI000770 GB13922 AGAP001103 AAEL012723 PHUM413460 GLEAN_04803
Synonyms & Secondary IDs ( 40 )
Reported As
Symbol Synonym	CG15793 (Morrison et al., 2000, Mouchel-Vielh et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) Dmek (Mantrova and Hsu, 1998) D-MEK (Hermon et al., 1998) D-Mek (Perrimon et al., 1995) D-mek (Morisato and Anderson, 1995, Hsu and Perrimon, 1994, Lu et al., 1994) dMEK (Lee et al., 2002, Kim et al., 2004) DMEK-1 (Duffy and Perrimon, 1994) D-MEK/Dsor (Baek and Lee, 1999) DRODSOR1 (Fernando Vazquez et al., 2000, Lopez et al., 1999, Schug et al., 1997) Dsor (Read et al., 2005, Kockel et al., 2001, Baker et al., 2002, Borland et al., 2001, Roman and Davis, 2001, Li et al., 2000, Jimenez et al., 2000, Meier and Evan, 1998, Kurada and White, 1998, Tang et al., 1997, Cagan, 1993, Guichard et al., 2006, Harrison et al., 2005, Bianco et al., 2007, Legent et al., 2008, Cinnamon et al., 2008, Guichard et al., 2006, Helman et al., 2011) D-SOR (Martin-Blanco, 2000) D-sor (Janody et al., 2000) DSor (Ip and Davis, 1998, Therrien et al., 1995) dSor (Lee et al., 2002) D-Sor (Sackton et al., 2007) DSor1 (Wilson et al., 2005) DSOR1 (Clemens et al., 2000, Raabe, 2000) dsor1 (Moodie and Wolfman, 1994) D-sor-1 (Perrimon and Desplan, 1994) Dsor1 (Lim et al., 1997, Nishimura et al., 2007, Michellod et al., 2003, Walker et al., 2006, Christensen et al., 2008.6.11, Christensen et al., 2008.6.11, Dawes-Hoang and Wieschaus, 2001, Christensen et al., 2008.12.28, Mogila et al., 2006, Nishimura et al., 2007, Xia et al., 2008, Mouchel-Vielh et al., 2008, Oishi et al., 2006, Hill-Burns and Clark, 2009, Guichard et al., 2006, Sims et al., 2009, Zhou et al., 2008, Maher et al., 2011, Zeng et al., 2010) dSor1 (Majumdar et al., 2010) DSORT (Claeys et al., 2002) EK1-1 (Therrien et al., 2000) MAPKK (Kumar and Moses, 2000, Marshall, 1994, Yoneda et al., 2007, Bianco et al., 2007, Dawes-Hoang and Wieschaus, 2001, Herr et al., 2010) MEK (Douziech et al., 2003, Rebay, 2002, Castelli-Gair Hombria and Brown, 2002, Roy and Therrien, 2002, Anselmo et al., 2002, Yokokura et al., 2002, Roy et al., 2002, Kumar and Moses, 2001, Kumar and Moses, 2001, Morrison et al., 2000, Perrimon and Duffy, 1998, Duffy et al., 1998, Lu and Li, 1998, Karim and Rubin, 1998, Karim et al., 1997, Badenhorst et al., 1996, Klaembt et al., 1996, Avruch et al., 1994, Mogila and Li, 2006, Douziech et al., 2006, Ashton-Beaucage and Therrien, 2007, Mogila et al., 2007, Vrailas et al., 2006, Kim et al., 2006, Walker et al., 2006, Harrison et al., 2005, Mogila et al., 2006, Mouchel-Vielh et al., 2008, Nie et al., 2009, Herr et al., 2010, Roignant and Treisman, 2010, Tipping et al., 2010, Majumdar et al., 2010) mek (Therrien et al., 2000, Ashton-Beaucage et al., 2010, Liu et al., 2010) Mek (Kumar and Moses, 2000) MEK1/2 (Ivanovska et al., 2004) MEK/Dsor1 (Friedman and Perrimon, 2006) SOR (Morrison et al., 2000) sor (Morrison et al., 2000) Sor (Kim et al., 2006) sor/MEK1 (Wilson et al., 2001) Su(Raf)34B (Zhang et al., 1999)
Name Synonym	Downstream of raf1 (Oishi et al., 2006) downstream suppressor of Raf 1 (Xia et al., 2008) Drosophila MEK (Mogila et al., 2007) Map kinase kinase (Harrison et al., 2005) MAP Kinase Kinase (Majumdar et al., 2010) MAPK kinase (Bianco et al., 2007)
Secondary FlyBase IDs
References ( 184 )
Generate a list of	All references relating to this gene ( 184 )
List References by type	Research paper  ( 95 ) Supplementary material  ( 5 ) Review  ( 44 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 21 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 10 )
	Helman et al., 2011, Curr. Biol. 21(13): 1102--1110 Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. [FBrf0214255] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270 ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618] Ashton-Beaucage et al., 2010, Cell 143(2): 251--262 The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. [FBrf0212064] Herr et al., 2010, Dev. Biol. 344(1): 36--51 Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila. [FBrf0211319] Liu et al., 2010, Sci. Signal. 3(132): ra57 The Drosophila Female Germline Stem Cell Lineage Acts to Spatially Restrict DPP Function Within the Niche. [FBrf0211426] Majumdar et al., 2010, Fly 4(3): 204--212 MAP Kinase phosphorylation is dispensable for cell division, but required for cell growth in Drosophila. [FBrf0216352] Roignant and Treisman, 2010, Cell 143(2): 238--250 Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene. [FBrf0212083] Tipping et al., 2010, EMBO J. 29(19): 3222--3235 β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. [FBrf0211995] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...