FlyBase Gene Report: Dmel\Ssrp

General Information

Symbol

Dmel\Ssrp

Species

D. melanogaster

Name

Structure specific recognition protein

Annotation Symbol

CG4817

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010278

Gene Model Status

Stock Availability

12 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

SSRP1, dSSRP1

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:23,806,361..23,809,004 [-]

Recombination map

2-105

RefSeq locus

NT_033778 REGION:23806361..23809004

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables nucleosomal DNA binding

inferred from direct assay

(Tsunaka et al., 2009)

enables nucleosome binding

inferred from direct assay

(Shimojima et al., 2003)

enables protein binding

inferred from physical interaction with FLYBASE:Trl; FB:FBgn0013263

(Shimojima et al., 2003)

enables protein self-association

inferred from direct assay

(Tsunaka et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables histone binding

inferred from biological aspect of ancestor with PANTHER:PTN002492356

(assigned by GO_Central )

(Gaudet et al., 2011)

enables nucleosome binding

inferred from biological aspect of ancestor with PANTHER:PTN002492356

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in negative regulation of protein phosphorylation

inferred from mutant phenotype

(assigned by UniProt )

(Dopie et al., 2015)

involved_in ovarian follicle cell development

inferred from mutant phenotype

(Jia et al., 2015)

involved_in positive regulation of actin filament polymerization

inferred from mutant phenotype

(assigned by UniProt )

(Dopie et al., 2015)

involved_in regulation of chromatin assembly or disassembly

inferred from mutant phenotype

(Shimojima et al., 2003)

involved_in regulation of DNA binding

inferred from mutant phenotype

(Tsunaka et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of chromatin organization

inferred from biological aspect of ancestor with PANTHER:PTN008168559

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of FACT complex

inferred from direct assay

(Tsunaka et al., 2009)

located_in nucleolus

inferred from direct assay

(Swenson et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of FACT complex

traceable author statement

(Lehmann, 2004)

inferred from biological aspect of ancestor with PANTHER:PTN002492356

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the SSRP1 family. (Q05344)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

FACT COMPLEX -: FACT (facilitates chromatin transcription) is a heterodimer that destabilizes interactions between the H2A/H2B dimer and the H3/H4 tetramer of nucleosomes. FACT is involved in multiple processes such as transcription elongation, DNA replication and repair. (Adapted from FBrf0208591).
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -: The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).

Protein Function (UniProtKB)

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.

(UniProt, Q05344)

Summary (Interactive Fly)

transcription factor - along with Dre4 forms a protein complex, FACT, that facilates GAGA factor directed chromatin remodeling

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Ssrp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0072242

2507

723

Additional Transcript Data and Comments

Reported size (kB)

2.6 (northern blot)

(Hsu et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0072151

81.5

723

5.31

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

723 (aa); 81 (kD)

(Bruhn et al., 1993, Hsu et al., 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the FACT complex, a stable heterodimer of dre4/spt16 and Ssrp. Interacts with CHD1 and TRL/GAGA.

(UniProt, Q05344)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q05344

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ssrp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ssrp_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

(Hsu et al., 1993)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

(Hsu et al., 1993)

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Ssrp transcripts are found in ovaries and are abundant throughout oogenesis. Transcripts are also found in nurse cells and the nurse cell expression is highest during stages S10-S12. Transcript levels remain high during embryogenesis but drop during larval stages.

(Hsu et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Ssrp protein is localized to the nucleus and is particularly abundant in the nucleolus.

(Hsu et al., 1993)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of FACT complex

inferred from direct assay

(Tsunaka et al., 2009)

located_in nucleolus

inferred from direct assay

(Swenson et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ssrp in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ssrp

View exonic expression by tissue for Dmel\Ssrp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010278

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010278

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4817-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4817

Flygut - An atlas of the Drosophila adult midgut

FBgn0010278

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ssrp

Transgenic constructs containing regulatory region of Ssrp

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

Ssrp^GD12795

lethal, with Scer\GAL4^Mef2.PR

Ssrp^GD12795

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Ssrp^GD12795

lethal - all die during pharate adult stage, with Scer\GAL4^Act5C.PI

Ssrp^JF02120

viable, with Scer\GAL4^tin.CΔ4

Ssrp^GD12795

Other Phenotypes

Allele

neuroanatomy defective | larval stage

Ssrp^GD12795

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ssrp^GD12795

visible, with Scer\GAL4^pnr-MD237

Ssrp^GD12795

visible | male limited, with Scer\GAL4^Bx-MS1096

Ssrp^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

antenna, with Scer\GAL4^Act5C.PI

Ssrp^JF02120

eye, with Scer\GAL4^Act5C.PI

Ssrp^JF02120

eye-antennal disc, with Scer\GAL4^Act5C.PI

Ssrp^JF02120

ganglion mother cell | larval stage

Ssrp^GD12795

head capsule, with Scer\GAL4^Act5C.PI

Ssrp^JF02120

larval neuroblast | larval stage

Ssrp^GD12795

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Ssrp^GD12795

sarcomere, with Scer\GAL4^Mef2.PR

Ssrp^GD12795

wing | male limited, with Scer\GAL4^Bx-MS1096

Ssrp^{UAS.ORF.GW.Tag:HA}

Z disc, with Scer\GAL4^Mef2.PR

Ssrp^GD12795

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

1 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

Rattus norvegicus (Norway rat) (1)

9 of 13

Yes

Yes

Xenopus tropicalis (Western clawed frog) (2)

7 of 12

Yes

Yes

1 of 12

No

No

Danio rerio (Zebrafish) (2)

12 of 15

Yes

Yes

11 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

15 of 15

Yes

Yes

14 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (1)

9 of 9

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

12 of 15

Yes

Yes

2 of 15

No

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

9 of 12

Yes

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904SR )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00002167

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502PE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY009339

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09360

Mayetiola destructor

Hessian fly

Mdes\Mdes008706

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011425

Anopheles darlingi

American malaria mosquito

Adar\ADAC005115

Anopheles gambiae

Malaria mosquito

Agam\AGAP012335

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002953

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0326 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005288

Danaus plexippus

Monarch butterfly

Dple\DPOGS207725-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015307

Apis florea

Little honeybee

Aflo\3365955700

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001c73

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012617

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM125270

Rhodnius prolixus

Kissing bug

Rpro\RPRC006380

Cimex lectularius

Bed bug

Clec\CLEC003860

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008511

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006576

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06426

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02Z1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR015352

Ixodes scapularis

Black-legged tick

Isca\ISCW020032

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60569.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g10640

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_201206

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04JP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ssrp1_1

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_025332gn

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000000505

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (6)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SSRP1; structure specific recognition protein 1

13 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

nuclear magnetic resonance, comigration in non denaturing gel electrophoresis, molecular weight estimation by staining

(Hashimoto et al., 2013, Tsunaka et al., 2009)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Lipinszki et al., 2015)

experimental knowledge based

(Guruharsha et al., 2011)

pull down, anti tag western blot, tandem affinity purification, multidimensional protein identification technology, western blot, anti bait coimmunoprecipitation

(Lee et al., 2019, Kwon et al., 2010)

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, tandem affinity purification, multidimensional protein identification technology

(Lee et al., 2019, Kwon et al., 2010)

Ssrp - Su(var)205

tandem affinity purification, multidimensional protein identification technology, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down, anti bait coimmunoprecipitation

(Lee et al., 2019, Kwon et al., 2010)

anti tag coimmunoprecipitation, western blot, pull down, anti tag western blot, peptide massfingerprinting

(Nakayama et al., 2012, Shimojima et al., 2003)

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(Boltengagen et al., 2016)

anti bait coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, western blot, experimental knowledge based

(Guruharsha et al., 2011, Kwon et al., 2010, Tsunaka et al., 2009, Shimojima et al., 2003)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of the FACT complex, a stable heterodimer of dre4/spt16 and Ssrp. Interacts with CHD1 and TRL/GAGA.

(UniProt, Q05344 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63363

DroID - A comprehensive database of gene and protein interactions.

FBgn0010278

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37767

MIST (protein-protein) - An integrated Molecular Interaction Database

Ssrp

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-105

Cytogenetic map

Sequence location

2R:23,806,361..23,809,004 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A2-60A2

Limits computationally determined from genome sequence between P{EP}egl^EP938 and P{lacW}eIF6^k13214

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60A1-60A4

(Bruhn, 1992.9.16)

60A1-60A4

(determined by in situ hybridisation)

(Bruhn et al., 1993, Hsu et al., 1993)

Experimentally Determined Recombination Data

Location

2-105

(FlyBase, 2016)

2-109.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

26222

y¹ v¹; P{TRiP.JF02120}attP2

80873

y¹, v¹; P{TKO.GS04777}attP40

67389

y¹ w^*; PBac{Ssrp-GFP.FPTB}VK00033

29686

y¹ w^*; P{EP}Ssrp^G2947/CyO

80753

y¹ sc^* v¹ sev²¹; P{TOE.GS02137}attP40

41719

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02285}attP2

35455

y¹ sc^* v¹ sev²¹; P{TRiP.GL00381}attP2/TM3, Sb¹

51519

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03169}attP2/TM3, Sb¹

F001903

M{UAS-Ssrp.ORF.3xHA.GW}ZH-86Fb

v44343

w¹¹¹⁸; P{GD12795}v44343

v44344

w¹¹¹⁸; P{GD12795}v44344

v318267

PBac{fTRG00913.sfGFP-TVPTBF}VK00033

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (136)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD06504

Other clones

FI07619

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010278

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010278

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37767

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Tettey et al., 2019, Mazina et al., 2018, Shimojima et al., 2003, Hsu et al., 1993)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ssrp CG4817

(Zhang, 1999.11)

Source for database merge of

Additional comments

Other Comments

The FACT complex (FAcilitates Chromatin Transcription) containing dre4 and Ssrp has a crucial role in the modulation of chromatin structure for the regulation of gene expression.

(Shimojima et al., 2003)

Drosophila Ssrp identified by sequence similarity to human Ssrp gene.

(Bruhn et al., 1993)

cDNA encoding a developmentally regulated high-mobility-group (HMG) box-containing protein was isolated: the encoded protein binds single stranded DNA and RNA, rather than the expected structured DNA.

(Hsu et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37767

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q05344

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010278

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010278

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ssrp_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4817

Flygut - An atlas of the Drosophila adult midgut

FBgn0010278

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37767

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4817

modMine - A data warehouse for the modENCODE project

FBgn0010278

Linkouts

BioGRID - A database of protein and genetic interactions.

63363

DroID - A comprehensive database of gene and protein interactions.

FBgn0010278

DRSC - Results frm RNAi screens

FBgn0010278

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010278

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4817-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010278

FlyMine - An integrated database for Drosophila genomics

FBgn0010278

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37767

MIST (protein-protein) - An integrated Molecular Interaction Database

Ssrp

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG4817

(Boltengagen et al., 2016, Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009.3.31)

Cf5

DssRP

(Hsu et al., 1993)

SSRP

(Andersen et al., 2010, Hsu, 1993)

SSRP1

(Aoki et al., 2020, Bhargava et al., 2020, Mazina et al., 2017, Lipinszki et al., 2015, Hashimoto et al., 2013, Nakayama et al., 2012, Polo and Almouzni, 2006, Saunders et al., 2003, Kelley et al., 1999, Soullier et al., 1999, Bruhn, 1992.9.16)

dSSRP

(Wisniewski et al., 1999)

dSSRP1

(Lee et al., 2019, Kwon et al., 2010, Tsunaka et al., 2009, Nakayama et al., 2007, Lehmann, 2004, Shimojima et al., 2003)

dSsrp

(Yokoyama et al., 2007)

ssrp

(Neumüller et al., 2013, Levine and Begun, 2008)

Name Synonyms

Chorion factor

Structure specific recognition protein

structure-specific recognition protein

(Pedersen et al., 2008)

Secondary FlyBase IDs

FBgn0005644

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (100)