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Gene Dmel\TfIIFα

General Information
Symbol	Dmel\TfIIFα	Species	D. melanogaster
Name	Transcription factor IIFα	Annotation symbol	CG10281
Feature type	protein_coding_gene	FlyBase ID	FBgn0010282
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	TFIIF, TfIIFalpha
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83E5-83E5	Sequence location	3R:2,206,181..2,208,326 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transcription factor IIFα is referred to in FlyBase by the symbol Dmel\TfIIFα (CG10281, FBgn0010282). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: TFIIF-class transcription factor binding. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription initiation from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter; neurogenesis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Transcription Factor IIF, Rap30/Rap74, interaction; Transcription initiation factor IIF, alpha subunit; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640495_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TfIIFalpha. Gene sequence location is 3R:2206181..2208326.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	References Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Sequence features HFA12608 BKN45044 BKN22964 Controlled Vocabulary Terms positive regulation of transcription initiation from RNA polymerase II promoter positive regulation of transcription elongation from RNA polymerase II promoter TFIIF-class transcription factor binding positive regulation of transcription from RNA polymerase II promoter
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83E5-83E5   Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TfIIFα for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TfIIFα-RA FBtr0081719  NM_079522   1946   577
Additional Transcript Data & Comments
Reported size (kB)	1.929 (longest cDNA) (Kephart et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TfIIFα-PA   FBpp0081216   64.5   577   8.45     NP_524246   AAF54125
Additional Polypeptide Data & Comments
Reported size (kDa)	577 (aa) (Gong et al., 1993, Kephart et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription Factor IIF, Rap30/Rap74, interaction (IPR011039) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Transcription initiation factor IIF, alpha subunit (IPR008851)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA942112   AA950244   AA979296   AE014297 AAF54125   AI113577   AI239135   AW942831   AY051733 AAK93157   BI162707   BI164316   BI216747   BI240525   BI354356   BI372074   BI372490   BI616122   BP546089   BP546958   BP549767   BP549768   CK131621   CK135429   CO187322   CO265582   CO291805   CZ472255   CZ472256   EC080470   EC203605   EC244679   EV580147   EV596898   GH752989   GH753027   GH757986   GH758607   GH759319   GH774001   GH778122   GH778760   GH780615   GH782546   GH783061   GH785617   GH786651   GH787646   GH795170   GH795587   GH796009   GH796800   GH797387   GH802428   GH804166   GH804881   GH807261   GH816298   GH821489   GH826600   GH833085   GH836657   GH837048   GH839248   GH841795   GH844536   GH848093   GH850481   GH854448   GH865613   GH876086   GH884498   GH884866   GH886541   GH887562   GH888841   GH889121   GH895293   GH898650   GH902605   GH904162   GH905994   GH906263   GH912450   GH915591   GH919046   GH920072   GH922290   GH925984   GH930913   GH932224   GH932670   GH938328   GH939997   L10331   X66982 CAA47391
UniProtKB/Swiss-Prot	Q05913
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (Arbeitman et al., 2004) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage | female   germline cell   (Arbeitman et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010282    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010282 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010282 expression level Developmental Stage   Expression Level embryo 00-02hr    7686 embryo 02-04hr    11572 embryo 04-06hr    10370 embryo 06-08hr    4973 embryo 08-10hr    4896 embryo 10-12hr    3262 embryo 12-14hr    3024 embryo 14-16hr    3272 embryo 16-18hr    2860 embryo 18-20hr    1462 embryo 20-22hr    3755 embryo 22-24hr    3361 larva L1    1315 larva L2    2094 larva L3 12hr old    1697 larva L3 puffstage 1-2    1513 larva L3 puffstage 3-6    1792 larva L3 puffstage 7-9    2215 white prepupae new    2204 white prepupae 12hr    1955 white prepupae 24hr    2404 pupae 2d postWPP    1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day    1473 adult male 05day    1707 adult male 30day    1703 adult female 01day    2823 adult female 05day    4656 adult female 30day    4831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7686) embryo 02-04hr  (11572) embryo 04-06hr  (10370) embryo 06-08hr  (4973) embryo 08-10hr  (4896) embryo 10-12hr  (3262) embryo 12-14hr  (3024) embryo 14-16hr  (3272) embryo 16-18hr  (2860) embryo 18-20hr  (1462) embryo 20-22hr  (3755) embryo 22-24hr  (3361) larva L1  (1315) larva L2  (2094) larva L3 12hr old  (1697) larva L3 puffstage 1-2  (1513) larva L3 puffstage 3-6  (1792) larva L3 puffstage 7-9  (2215) white prepupae new  (2204) white prepupae 12hr  (1955) white prepupae 24hr  (2404) pupae 2d postWPP  (1923) pupae 3d postWPP  (1306) pupae 4d postWPP  (992) adult male 01day  (1473) adult male 05day  (1707) adult male 30day  (1703) adult female 01day  (2823) adult female 05day  (4656) adult female 30day  (4831) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7686) embryo 02-04hr  (11572) embryo 04-06hr  (10370) embryo 06-08hr  (4973) embryo 08-10hr  (4896) embryo 10-12hr  (3262) embryo 12-14hr  (3024) embryo 14-16hr  (3272) embryo 16-18hr  (2860) embryo 18-20hr  1462 embryo 20-22hr  (3755) embryo 22-24hr  (3361) larva L1    1315 larva L2  (2094) larva L3 12hr old  (1697) larva L3 puffstage 1-2  (1513) larva L3 puffstage 3-6  (1792) larva L3 puffstage 7-9  (2215) white prepupae new  (2204) white prepupae 12hr  (1955) white prepupae 24hr  (2404) pupae 2d postWPP  (1923) pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day  1473 adult male 05day  (1707) adult male 30day  (1703) adult female 01day  (2823) adult female 05day  (4656) adult female 30day  (4831) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7686 embryo 02-04hr  (11572) embryo 04-06hr  10370 embryo 06-08hr    4973 embryo 08-10hr    4896 embryo 10-12hr    3262 embryo 12-14hr    3024 embryo 14-16hr    3272 embryo 16-18hr    2860 embryo 18-20hr    1462 embryo 20-22hr    3755 embryo 22-24hr    3361 larva L1    1315 larva L2    2094 larva L3 12hr old    1697 larva L3 puffstage 1-2    1513 larva L3 puffstage 3-6    1792 larva L3 puffstage 7-9    2215 white prepupae new    2204 white prepupae 12hr    1955 white prepupae 24hr    2404 pupae 2d postWPP    1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day    1473 adult male 05day    1707 adult male 30day    1703 adult female 01day    2823 adult female 05day    4656 adult female 30day    4831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7686 embryo 02-04hr    11572 embryo 04-06hr    10370 embryo 06-08hr    4973 embryo 08-10hr    4896 embryo 10-12hr    3262 embryo 12-14hr    3024 embryo 14-16hr    3272 embryo 16-18hr    2860 embryo 18-20hr    1462 embryo 20-22hr    3755 embryo 22-24hr    3361 larva L1    1315 larva L2    2094 larva L3 12hr old    1697 larva L3 puffstage 1-2    1513 larva L3 puffstage 3-6    1792 larva L3 puffstage 7-9    2215 white prepupae new    2204 white prepupae 12hr    1955 white prepupae 24hr    2404 pupae 2d postWPP    1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day    1473 adult male 05day    1707 adult male 30day    1703 adult female 01day    2823 adult female 05day    4656 adult female 30day    4831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010282 expression level Developmental Stage   Expression Level embryo 00-02hr    7686 embryo 02-04hr    11572 embryo 04-06hr    10370 embryo 06-08hr    4973 embryo 08-10hr    4896 embryo 10-12hr    3262 embryo 12-14hr    3024 embryo 14-16hr    3272 embryo 16-18hr    2860 embryo 18-20hr    1462 embryo 20-22hr    3755 embryo 22-24hr    3361 larva L1    1315 larva L2    2094 larva L3 12hr old    1697 larva L3 puffstage 1-2    1513 larva L3 puffstage 3-6    1792 larva L3 puffstage 7-9    2215 white prepupae new    2204 white prepupae 12hr    1955 white prepupae 24hr    2404 pupae 2d postWPP    1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day    1473 adult male 05day    1707 adult male 30day    1703 adult female 01day    2823 adult female 05day    4656 adult female 30day    4831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7686) embryo 02-04hr  (11572) embryo 04-06hr  (10370) embryo 06-08hr  (4973) embryo 08-10hr  (4896) embryo 10-12hr  (3262) embryo 12-14hr  (3024) embryo 14-16hr  (3272) embryo 16-18hr  (2860) embryo 18-20hr  (1462) embryo 20-22hr  (3755) embryo 22-24hr  (3361) larva L1  (1315) larva L2  (2094) larva L3 12hr old  (1697) larva L3 puffstage 1-2  (1513) larva L3 puffstage 3-6  (1792) larva L3 puffstage 7-9  (2215) white prepupae new  (2204) white prepupae 12hr  (1955) white prepupae 24hr  (2404) pupae 2d postWPP  (1923) pupae 3d postWPP  (1306) pupae 4d postWPP  (992) adult male 01day  (1473) adult male 05day  (1707) adult male 30day  (1703) adult female 01day  (2823) adult female 05day  (4656) adult female 30day  (4831) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7686) embryo 02-04hr  (11572) embryo 04-06hr  (10370) embryo 06-08hr  (4973) embryo 08-10hr  (4896) embryo 10-12hr  (3262) embryo 12-14hr  (3024) embryo 14-16hr  (3272) embryo 16-18hr  (2860) embryo 18-20hr  1462 embryo 20-22hr  (3755) embryo 22-24hr  (3361) larva L1    1315 larva L2  2094 larva L3 12hr old  1697 larva L3 puffstage 1-2  1513 larva L3 puffstage 3-6  1792 larva L3 puffstage 7-9  2215 white prepupae new  2204 white prepupae 12hr  1955 white prepupae 24hr  2404 pupae 2d postWPP  1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day  1473 adult male 05day  1707 adult male 30day  1703 adult female 01day  (2823) adult female 05day  (4656) adult female 30day  (4831) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7686 embryo 02-04hr  11572 embryo 04-06hr  10370 embryo 06-08hr    4973 embryo 08-10hr    4896 embryo 10-12hr    3262 embryo 12-14hr    3024 embryo 14-16hr    3272 embryo 16-18hr    2860 embryo 18-20hr    1462 embryo 20-22hr    3755 embryo 22-24hr    3361 larva L1    1315 larva L2    2094 larva L3 12hr old    1697 larva L3 puffstage 1-2    1513 larva L3 puffstage 3-6    1792 larva L3 puffstage 7-9    2215 white prepupae new    2204 white prepupae 12hr    1955 white prepupae 24hr    2404 pupae 2d postWPP    1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day    1473 adult male 05day    1707 adult male 30day    1703 adult female 01day    2823 adult female 05day    4656 adult female 30day    4831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7686 embryo 02-04hr    11572 embryo 04-06hr    10370 embryo 06-08hr    4973 embryo 08-10hr    4896 embryo 10-12hr    3262 embryo 12-14hr    3024 embryo 14-16hr    3272 embryo 16-18hr    2860 embryo 18-20hr    1462 embryo 20-22hr    3755 embryo 22-24hr    3361 larva L1    1315 larva L2    2094 larva L3 12hr old    1697 larva L3 puffstage 1-2    1513 larva L3 puffstage 3-6    1792 larva L3 puffstage 7-9    2215 white prepupae new    2204 white prepupae 12hr    1955 white prepupae 24hr    2404 pupae 2d postWPP    1923 pupae 3d postWPP    1306 pupae 4d postWPP    992 adult male 01day    1473 adult male 05day    1707 adult male 30day    1703 adult female 01day    2823 adult female 05day    4656 adult female 30day    4831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010282    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010282 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010282 expression level Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010282 expression level Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.125 Larval Midgut    152.8 Larval Hindgut    192.7 Larval Malpighian Tubules    137.6 Larval Fat Body    203.6 Larval Salivary Gland    493.6 Larval Trachea    212.8 Larval Carcass    239.575 Adult Head    118 Adult Eye    92.425 Adult Brain    153 Adult Thoracic-Abdominal Ganglion    136.1 Adult Crop    140.4 Adult Midgut    139.1 Adult Hindgut    135.9 Adult Malpighian Tubules    109.1 Adult Fat Body    132 Adult Salivary Gland    271.5 Adult Heart    90.45 Adult VirginFemale Spermatheca    91.8 Adult InseminatedFemale Spermatheca    112.3 Adult Ovary    429.8 Adult Testis    179.8 Adult Male Accessory Gland    315.5 Adult Carcass    129.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    118   NA  Eye    92.425   NA  Brain    153   285.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    136.1   NA  Crop    140.4   152.8  Midgut    139.1   192.7  Hindgut    135.9   137.6  Malpighian Tubules    109.1   203.6  Fat Body    132   493.6  Salivary Gland    271.5   NA  Heart    90.45   212.8  Trachea    NA   NA  VirginFemale Spermatheca    91.8   NA  InseminatedFemale Spermatheca    112.3   NA  Ovary    429.8   NA  Testis    179.8   NA  Male Accessory Gland    315.5   239.575  Carcass    129.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010282 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10281-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 TfIIFαGD4143 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 TfIIFαGD4143 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 TfIIFαGD4143 ganglion mother cell | larval stage, with Scer\GAL41407 TfIIFαGD4143
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of TfIIFα Class Mutagen Stocks Known lesion TfIIFαd01485 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TfIIFα Class Mutagen Stocks Known lesion TfIIFαGD4143 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TfIIFαGL00352 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TfIIFαKK102868 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}TfIIFαd01485 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
TFIIF-class transcription factor binding inferred from physical interaction with TfIIFβ (Gong et al., 1995)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of transcription elongation from RNA polymerase II promoter inferred from direct assay (Kephart et al., 1994) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Gong et al., 1995) positive regulation of transcription initiation from RNA polymerase II promoter inferred from direct assay (Kephart et al., 1994)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Gong et al., 1995) transcription factor TFIIF complex inferred from direct assay (Austin and Biggin, 1996)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
catalytic activity inferred from electronic annotation with InterPro:IPR011039 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR008851 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with human GTF2F1 AND inferred from sequence or structural similarity with Saccharomyces TFG1 (Aoyagi and Wassarman, 2000)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) transcription factor TFIIF complex inferred from sequence or structural similarity with human GTF2F1 AND inferred from sequence or structural similarity with Saccharomyces TFG1 (Aoyagi and Wassarman, 2000) non-traceable author statement (Kephart, 1992.6.22, Gong, 1993.4.26)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TfIIFα allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65991 DroID - A comprehensive database of gene and protein interactions. • FBgn0010282 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40790
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18359 Dere\GG13412 Dgri\GH19532 Dmoj\GI23011 Dper\GL21747 Dpse\GA26384 Dsec\GM10893 Dsim\GD19872 Dvir\GJ24604 Dwil\GK12178 Dyak\GE10218
Curated drosophilid orthologs	Dpse\GA10217
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003945-PA Aedes aegypti (mosquito) AGAP002779-PA Anopheles gambiae (mosquito) XP_001122801.1 Apis mellifera (honey bee) XP_001946541.1 Acyrthosiphon pisum (pea aphid) At4g12610.1 Arabidopsis thaliana (wall cress) 21955 Batrachochytrium dendrobatidis (chytrid fungus) 82771 Branchiostoma floridae (lancelet) XP_001894415.1 Brugia malayi (roundworm nematode) BGIBMGA003305-PA Bombyx mori (silk worm) ENSBTAP00000048457 Bos taurus (bovine) CN14772 Caenorhabditis brenneri (small nematode) CBP06642 Caenorhabditis briggsae (nematode) CE06742 Caenorhabditis elegans (worm) ENSCAFP00000027562 Canis familiaris (dog) ENSCINP00000003594 Ciona intestinalis (sea squirt) JA14292 Caenorhabditis japonica (nematode) CPIJ009645 Culex pipens (mosquito) ENSCPOP00000011364 Cavia porcellus (guinea pig) RP31982 Caenorhabditis remanei (nematode) ENSCSAVP00000004503 Ciona savignyi (sedentary tunicate) 225119 Capitella spl (polychaete worm) DDB0302526 Dictyostelium discoideum (amoeba) 309148 Daphnia pulex (daphnia) ENSDARP00000047659 Danio rerio (zebra fish) ENSECAP00000000251 Equus caballus (horse) ENSGACP00000016765 Gymnopilus aculeatus (mushroom) 184964 Hypsipyla robusta (cedar shoot borer) ENSP00000377969 Homo sapiens (human) ENSMODP00000002316 Monodelphis domestica (gray opossum) ENSMMUP00000010376 Macaca mulatta (rhesus monkey) ENSMUSP00000002733 Mus musculus (house mouse) XP_001607159.1 Nasonia vitripennis (wasp) ENSOANP00000009747 Ornithorynchus anatinus (platypus) LOC_Os10g10990.1 Oryza sativa (asian rice) PHUM010274-PA Pediculus humanus (human body louse) 50627 Physcomitrella patens (moss) ENSPPYP00000010599 Pongo pygmaeus (orangutan) ENSPTRP00000017625 Pan troglodytes (chimpanzee) Smp_088460 Schistosoma mansoni (trematode parasite) XP_001189317.1 Strongylocentrotus purpuratus (purple sea urchin) 59215 Trichoplax adhaerens (metazoa) XP_973020.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015598 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000016178 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000012282 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV25727 NV14066 LH23176 ISCW000657 ISCW000655 FBgn0228092 FBgn0214189 FBgn0211682 FBgn0191360 FBgn0165839 JGI_V11_309148 FBgn0247758 FBgn0159340 FBgn0145738 FBgn0126997 FBgn0105684 FBgn0095377 CPIJ014425 CPIJ009645 BGIBMGA003305 GB30294 GB15264 AGAP002779 AAEL003945 PB22870 PHUM493990 GLEAN_11225
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	35428 y1 sc* v1; P{TRiP.GL00352}attP2
Harvard	- P{XP}TfIIFαd01485
VDRC	v51209 w1118; P{GD4143}v51209 v51211 w1118; P{GD4143}v51211
Genomic Clones ( 2 )
	BACR19H03 BACR32D05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD26157
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09928 GM02833 GM22745 LD28729 LD33679 LP12524 RE01951 RE03968 RE23985 RE37378 RE58201 RE59463
Other clones	Dmel_dig_013265_0663_1877 Dmel_neb_010883_0896_0682 EK028159 EK143125 EK198353 FGH102G01 FGH111H08 FGM103D03 RH45982 RP003003482 RP003055948 RP003058420 RP003081104 RP003088364 RP003105807 RP003110948 RP003114225 RP003119338 RP003152558 RP003156193 RP003161496 RP003177480 RP003200750 RP003211661 RP003230037 RP003237107 RP003237910 RP003245247 RP003260755 RP003272424 RP003278904 RP003282146 RP003295438 RP003305349 RP003310545 RP003323499 RP003324533 RP003327192 RP003338387 RP003346828 RP003388080 RP003421225 RP003428598 RP003443811 RP003471714 RP003472248 RP003475555 RP003480919 RP003485366 RP003486707 RP003491199 RP003509065 RP003516039 RP003535430 RP003548385 RP003549894 RP003553721 RP003560487 RP003562985 RP003566424 RP003582004 RP003588619 RP003588691 RP003594729 RP003639329 RP003648834 RP003657195 RP003659842 RP003681611
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010282 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40790
Antibody Information
	polyclonal (Kephart et al., 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TfIIFα CG10281 (Wang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	TfIIF has been purified and shown to include two subunits. (Austin and Biggin, 1996) Analysis of TfIIFα deletion constructs in vitro suggests that almost all of the protein is required for transcription initiation, while only the N-terminal region is required for stimulation of transcription elongation. (Kephart et al., 1994) Drosophila TfIIFα cloned by low-stringency hybridisation to human TfIIFα cDNA. (Gong et al., 1993) Cloned by sequence similarity to human RAP74 protein. (Kephart et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079522 RefSeq (Proteins) • NP_524246 DDBJ / EMBL / GenBank • AA942112 AAF54125 AAK93157 AW942831 AY051733 BI616122 CAA47391 CZ472255 CZ472256 L10331 X66982 Entrez Gene - A searchable database of RefSeq genes. • 40790 UniProtKB/Swiss-Prot • Q05913
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription Factor IIF, Rap30/Rap74, interaction (IPR011039) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Transcription initiation factor IIF, alpha subunit (IPR008851)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65991 DroID - A comprehensive database of gene and protein interactions. • FBgn0010282 DRSC - Results from RNAi screens. • FBgn0010282 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010282 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10281-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010282 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40790 InParanoid A subset of ortholog calls from InParanoid. • AAEL003945-PA Aedes aegypti (mosquito) AGAP002779-PA Anopheles gambiae (mosquito) XP_001122801.1 Apis mellifera (honey bee) XP_001946541.1 Acyrthosiphon pisum (pea aphid) At4g12610.1 Arabidopsis thaliana (wall cress) 21955 Batrachochytrium dendrobatidis (chytrid fungus) 82771 Branchiostoma floridae (lancelet) XP_001894415.1 Brugia malayi (roundworm nematode) BGIBMGA003305-PA Bombyx mori (silk worm) ENSBTAP00000048457 Bos taurus (bovine) CN14772 Caenorhabditis brenneri (small nematode) CBP06642 Caenorhabditis briggsae (nematode) CE06742 Caenorhabditis elegans (worm) ENSCAFP00000027562 Canis familiaris (dog) ENSCINP00000003594 Ciona intestinalis (sea squirt) JA14292 Caenorhabditis japonica (nematode) CPIJ009645 Culex pipens (mosquito) ENSCPOP00000011364 Cavia porcellus (guinea pig) RP31982 Caenorhabditis remanei (nematode) ENSCSAVP00000004503 Ciona savignyi (sedentary tunicate) 225119 Capitella spl (polychaete worm) DDB0302526 Dictyostelium discoideum (amoeba) 309148 Daphnia pulex (daphnia) ENSDARP00000047659 Danio rerio (zebra fish) ENSECAP00000000251 Equus caballus (horse) ENSGACP00000016765 Gymnopilus aculeatus (mushroom) 184964 Hypsipyla robusta (cedar shoot borer) ENSP00000377969 Homo sapiens (human) ENSMODP00000002316 Monodelphis domestica (gray opossum) ENSMMUP00000010376 Macaca mulatta (rhesus monkey) ENSMUSP00000002733 Mus musculus (house mouse) XP_001607159.1 Nasonia vitripennis (wasp) ENSOANP00000009747 Ornithorynchus anatinus (platypus) LOC_Os10g10990.1 Oryza sativa (asian rice) PHUM010274-PA Pediculus humanus (human body louse) 50627 Physcomitrella patens (moss) ENSPPYP00000010599 Pongo pygmaeus (orangutan) ENSPTRP00000017625 Pan troglodytes (chimpanzee) Smp_088460 Schistosoma mansoni (trematode parasite) XP_001189317.1 Strongylocentrotus purpuratus (purple sea urchin) 59215 Trichoplax adhaerens (metazoa) XP_973020.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015598 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000016178 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000012282 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40790 modMine - Data generated by the modENCODE project. • FBgn0010282 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV25727 NV14066 LH23176 ISCW000657 ISCW000655 FBgn0228092 FBgn0214189 FBgn0211682 FBgn0191360 FBgn0165839 JGI_V11_309148 FBgn0247758 FBgn0159340 FBgn0145738 FBgn0126997 FBgn0105684 FBgn0095377 CPIJ014425 CPIJ009645 BGIBMGA003305 GB30294 GB15264 AGAP002779 AAEL003945 PB22870 PHUM493990 GLEAN_11225
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	154355_at (Kristensen et al., 2005) CG10281 (Arbeitman et al., 2004, Aoyagi and Wassarman, 2000, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmTFIIF (Tombácz et al., 2009) F5a (Kephart et al., 1994) RAP74 (Maile et al., 2004) TFIIF (Gu et al., 2002, Breiling et al., 2001, Breiling et al., 2001, Mizuguchi et al., 2001, Pham et al., 1999, Schock et al., 1999, Hansen et al., 1997, Sauer et al., 1995, Sauer et al., 1995, ten Harmsel and Biggin, 1995, Kephart et al., 1992, Wampler et al., 1990, Andersen et al., 2010) TfIIF (Dynan and Gilman, 1993) TfIIFalpha (Giot et al., 2003, Neumüller et al., 2011) TFIIF-L (Park et al., 2001) TFIIFα (Gong et al., 1995) TfIIFα
Name Synonym	factor 5 (Kephart et al., 1992) factor 5a (Kephart et al., 1993) large subunit of transcription factor 5 (Kephart, 1992.6.22) TFIIF large subunit (Kim and Lis, 2005) Transcription factor IIFα
Secondary FlyBase IDs
	FBgn0010281
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. [FBrf0211794] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...