dUCH, ubiquitin carboxyl terminal hydrolase, UCH-D
Gene model reviewed during 5.44
Gene model reviewed during 5.45
1.1 (northern blot)
227 (aa); 30 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Uch using the Feature Mapper tool.
Uch transcripts were detected in all tissues and developmental stages tested. They are abundant in ovary, testis, and early embryos. By in situ hybridization, they are first detected in nurse cells at oogenesis stage S9. The strongest signal is seen at stage 10 and it remains present in nurse cells as they degenerate during stages 11-13. Transcripts are detected in the oocyte from stage S10. There appears to be a greater concentration of Uch transcript in the ventral nurse cells and in the ventral region of the oocyte. In embryos, a uniform level of transcript is seen in all cells. In the male gonad, staining is largely confined to the spermatocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Uch in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Uch CG4265
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Identified via an enhancer trap element reflecting the expression in nurse cells.