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Gene Dmel\Uch

General Information
Symbol	Dmel\Uch	Species	D. melanogaster
Name	Ubiquitin carboxy-terminal hydrolase	Annotation symbol	CG4265
Feature type	protein_coding_gene	FlyBase ID	FBgn0010288
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	UCH-D
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	22D4-22D4	Sequence location	2L:2,212,738..2,214,211 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ubiquitin carboxy-terminal hydrolase is referred to in FlyBase by the symbol Dmel\Uch (CG4265, FBgn0010288). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ubiquitin thiolesterase activity. There is experimental evidence that it is involved in the biological process: protein deubiquitination. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult fat body, adult salivary gland, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624240_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Uch. Gene sequence location is 2L:2212738..2214211.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22D4-22D4   Limits computationally determined from genome sequence between P{lacW}s4989 and P{lacW}Rab5k08232
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98F-98F     (Zhang, 1992.12.4) 98F-98F   (determined by in situ hybridisation)   (Zhang et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Uch for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Uch-RA FBtr0077844  NM_057592   1196   227 Uch-RB FBtr0303459  NM_001201752   1044   227 Uch-RC FBtr0330676  NM_001272986   1035   224
Additional Transcript Data & Comments
Reported size (kB)	1.1 (northern blot) (Zhang et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Uch-PA   FBpp0077516   25.9   227   5.22     NP_476940   AAF51291 Uch-PB   FBpp0292511   25.9   227   5.22     NP_001188681   ADV36932 Uch-PC   FBpp0303526   25.4   224   5.21     NP_001259915   AGB92452
Additional Polypeptide Data & Comments
Reported size (kDa)	227 (aa); 30 (kD predicted) (Zhang et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 (IPR001578) MEROPS - An information resource for peptidases and the proteins that inhibit them • C12.001
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698790   AE014134 AAF51291   AC004340   AE014134 ADV36932   AF145600 AAD38575   AE014134 AGB92452   AI062998   AI135399   AI401858   AI405282   AI542601   AI945696   AI946134   AI946760   BE662016   BE976933   BF496408   BF499173   BF500298   BF505550   BF506441   BI351996   BI354683   BI354862   BI374127   BI375034   BI618893   BI640704   BI641982   BP546052   BP552888   CK657117   CO154491   CO184338   CO273488   CO273947   CO292169   CO298373   CO311257   CO314619   DN154326   EC060493   EC086537   EC198112   EC202186   EC222649   EC237420   EC241874   EC260973   EV582297   EV587103   EV591989   EV598447   EV599174   GH813761   GH830239   GH840412   GH879721   GH912696   X69678 CAA49358   X69679 CAA49359
UniProtKB/Swiss-Prot	P35122
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited adult stage & oogenesis   nurse cell   (Zhang et al., 1993) oocyte   (Zhang et al., 1993) spermatogenesis & adult stage   spermatocyte   (Zhang et al., 1993)
Additional Descriptive Data
	Uch transcripts were detected in all tissues and developmental stages tested. They are abundant in ovary, testis, and early embryos. By in situ hybridization, they are first detected in nurse cells at oogenesis stage S9. The strongest signal is seen at stage 10 and it remains present in nurse cells as they degenerate during stages 11-13. Transcripts are detected in the oocyte from stage S10. There appears to be a greater concentration of Uch transcript in the ventral nurse cells and in the ventral region of the oocyte. In embryos, a uniform level of transcript is seen in all cells. In the male gonad, staining is largely confined to the spermatocytes. (Zhang et al., 1993)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult fat body, adult salivary gland, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1456.6 Larval Midgut    1296.3 Larval Hindgut    1051.1 Larval Malpighian Tubules    2373.5 Larval Fat Body    631.9 Larval Salivary Gland    1074.8 Larval Trachea    751.25 Larval Carcass    1175.625 Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut    528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart    566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary    1280.2 Adult Testis    1578.8 Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1456.6) Larval Midgut  (1296.3) Larval Hindgut  (1051.1) Larval Malpighian Tubules  (2373.5) Larval Fat Body  (631.9) Larval Salivary Gland  (1074.8) Larval Trachea  (751.25) Larval Carcass  (1175.625) Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut  528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart  (566.375) Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary  (1280.2) Adult Testis  (1578.8) Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1456.6) Larval Midgut  (1296.3) Larval Hindgut  1051.1 Larval Malpighian Tubules  (2373.5) Larval Fat Body    631.9 Larval Salivary Gland  1074.8 Larval Trachea    751.25 Larval Carcass  (1175.625) Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut    528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart    566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary  (1280.2) Adult Testis  (1578.8) Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1456.6 Larval Midgut    1296.3 Larval Hindgut    1051.1 Larval Malpighian Tubules    2373.5 Larval Fat Body    631.9 Larval Salivary Gland    1074.8 Larval Trachea    751.25 Larval Carcass    1175.625 Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut    528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart    566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary    1280.2 Adult Testis    1578.8 Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1456.6 Larval Midgut    1296.3 Larval Hindgut    1051.1 Larval Malpighian Tubules    2373.5 Larval Fat Body    631.9 Larval Salivary Gland    1074.8 Larval Trachea    751.25 Larval Carcass    1175.625 Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut    528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart    566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary    1280.2 Adult Testis    1578.8 Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1456.6) Larval Midgut  (1296.3) Larval Hindgut  (1051.1) Larval Malpighian Tubules  (2373.5) Larval Fat Body  631.9 Larval Salivary Gland  (1074.8) Larval Trachea  751.25 Larval Carcass  (1175.625) Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut  528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart  566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary  (1280.2) Adult Testis  (1578.8) Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1456.6 Larval Midgut  1296.3 Larval Hindgut  1051.1 Larval Malpighian Tubules  (2373.5) Larval Fat Body    631.9 Larval Salivary Gland  1074.8 Larval Trachea    751.25 Larval Carcass  1175.625 Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut    528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart    566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary  1280.2 Adult Testis  1578.8 Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1456.6 Larval Midgut    1296.3 Larval Hindgut    1051.1 Larval Malpighian Tubules    2373.5 Larval Fat Body    631.9 Larval Salivary Gland    1074.8 Larval Trachea    751.25 Larval Carcass    1175.625 Adult Head    263.4 Adult Eye    357.7 Adult Brain    367.8 Adult Thoracic-Abdominal Ganglion    486 Adult Crop    452.7 Adult Midgut    528.3 Adult Hindgut    406.8 Adult Malpighian Tubules    366.9 Adult Fat Body    229 Adult Salivary Gland    410.2 Adult Heart    566.375 Adult VirginFemale Spermatheca    241.1 Adult InseminatedFemale Spermatheca    230.8 Adult Ovary    1280.2 Adult Testis    1578.8 Adult Male Accessory Gland    483.5 Adult Carcass    296.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    263.4   NA  Eye    357.7   NA  Brain    367.8   1456.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    486   NA  Crop    452.7   1296.3  Midgut    528.3   1051.1  Hindgut    406.8   2373.5  Malpighian Tubules    366.9   631.9  Fat Body    229   1074.8  Salivary Gland    410.2   NA  Heart    566.375   751.25  Trachea    NA   NA  VirginFemale Spermatheca    241.1   NA  InseminatedFemale Spermatheca    230.8   NA  Ovary    1280.2   NA  Testis    1578.8   NA  Male Accessory Gland    483.5   1175.625  Carcass    296.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    234 central nervous system, larvae L3    241 central nervous system, pupae P8    81 head, virgin 1-day female    29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    35 head, mated 4-day male    29 head, mated 20-day male    37 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    109 digestive system, larvae L3 wandering    340 digestive system, 1-day adult    58 digestive system, 4-day adult    58 digestive system, 20-day adult    59 fat body, larvae L3 wandering    31 fat body, white prepupae    112 fat body, pupae P8    178 carcass, larvae L3 wandering    273 carcass, 1-day adult    29 carcass, 4-day adult    37 carcass, 20-day adult    36 ovary, virgin 4-day female    307 ovary, mated 4-day female    304 testis, mated 4-day male    341 accessory gland, mated 4-day male    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (234) central nervous system, larvae L3  (241) central nervous system, pupae P8  (81) head, virgin 1-day female  (29) head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female  (27) head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male  (35) head, mated 4-day male  (29) head, mated 20-day male  (37) salivary gland, larvae L3 wandering  (36) salivary gland, white prepupae  (109) digestive system, larvae L3 wandering  (340) digestive system, 1-day adult  (58) digestive system, 4-day adult  (58) digestive system, 20-day adult  (59) fat body, larvae L3 wandering  (31) fat body, white prepupae  (112) fat body, pupae P8  (178) carcass, larvae L3 wandering  (273) carcass, 1-day adult  (29) carcass, 4-day adult  (37) carcass, 20-day adult  (36) ovary, virgin 4-day female  (307) ovary, mated 4-day female  (304) testis, mated 4-day male  (341) accessory gland, mated 4-day male  (64) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (234) central nervous system, larvae L3  (241) central nervous system, pupae P8    81 head, virgin 1-day female    29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    35 head, mated 4-day male    29 head, mated 20-day male    37 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae  (109) digestive system, larvae L3 wandering  (340) digestive system, 1-day adult    58 digestive system, 4-day adult    58 digestive system, 20-day adult    59 fat body, larvae L3 wandering    31 fat body, white prepupae  (112) fat body, pupae P8  (178) carcass, larvae L3 wandering  (273) carcass, 1-day adult    29 carcass, 4-day adult    37 carcass, 20-day adult    36 ovary, virgin 4-day female  (307) ovary, mated 4-day female  (304) testis, mated 4-day male  (341) accessory gland, mated 4-day male    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    234 central nervous system, larvae L3    241 central nervous system, pupae P8    81 head, virgin 1-day female    29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    35 head, mated 4-day male    29 head, mated 20-day male    37 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    109 digestive system, larvae L3 wandering    340 digestive system, 1-day adult    58 digestive system, 4-day adult    58 digestive system, 20-day adult    59 fat body, larvae L3 wandering    31 fat body, white prepupae    112 fat body, pupae P8    178 carcass, larvae L3 wandering    273 carcass, 1-day adult    29 carcass, 4-day adult    37 carcass, 20-day adult    36 ovary, virgin 4-day female    307 ovary, mated 4-day female    304 testis, mated 4-day male    341 accessory gland, mated 4-day male    64 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    234 central nervous system, larvae L3    241 central nervous system, pupae P8    81 head, virgin 1-day female    29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    35 head, mated 4-day male    29 head, mated 20-day male    37 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    109 digestive system, larvae L3 wandering    340 digestive system, 1-day adult    58 digestive system, 4-day adult    58 digestive system, 20-day adult    59 fat body, larvae L3 wandering    31 fat body, white prepupae    112 fat body, pupae P8    178 carcass, larvae L3 wandering    273 carcass, 1-day adult    29 carcass, 4-day adult    37 carcass, 20-day adult    36 ovary, virgin 4-day female    307 ovary, mated 4-day female    304 testis, mated 4-day male    341 accessory gland, mated 4-day male    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (234) central nervous system, larvae L3  (241) central nervous system, pupae P8  (81) head, virgin 1-day female  29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female  27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male  (35) head, mated 4-day male  29 head, mated 20-day male  (37) salivary gland, larvae L3 wandering  (36) salivary gland, white prepupae  (109) digestive system, larvae L3 wandering  (340) digestive system, 1-day adult  (58) digestive system, 4-day adult  (58) digestive system, 20-day adult  (59) fat body, larvae L3 wandering  31 fat body, white prepupae  (112) fat body, pupae P8  (178) carcass, larvae L3 wandering  (273) carcass, 1-day adult  29 carcass, 4-day adult  (37) carcass, 20-day adult  (36) ovary, virgin 4-day female  (307) ovary, mated 4-day female  (304) testis, mated 4-day male  (341) accessory gland, mated 4-day male  (64) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (234) central nervous system, larvae L3  (241) central nervous system, pupae P8    81 head, virgin 1-day female    29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    35 head, mated 4-day male    29 head, mated 20-day male    37 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae  109 digestive system, larvae L3 wandering  (340) digestive system, 1-day adult    58 digestive system, 4-day adult    58 digestive system, 20-day adult    59 fat body, larvae L3 wandering    31 fat body, white prepupae  112 fat body, pupae P8  (178) carcass, larvae L3 wandering  (273) carcass, 1-day adult    29 carcass, 4-day adult    37 carcass, 20-day adult    36 ovary, virgin 4-day female  (307) ovary, mated 4-day female  (304) testis, mated 4-day male  (341) accessory gland, mated 4-day male    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    234 central nervous system, larvae L3    241 central nervous system, pupae P8    81 head, virgin 1-day female    29 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    27 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    35 head, mated 4-day male    29 head, mated 20-day male    37 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    109 digestive system, larvae L3 wandering    340 digestive system, 1-day adult    58 digestive system, 4-day adult    58 digestive system, 20-day adult    59 fat body, larvae L3 wandering    31 fat body, white prepupae    112 fat body, pupae P8    178 carcass, larvae L3 wandering    273 carcass, 1-day adult    29 carcass, 4-day adult    37 carcass, 20-day adult    36 ovary, virgin 4-day female    307 ovary, mated 4-day female    304 testis, mated 4-day male    341 accessory gland, mated 4-day male    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    200 embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2    43 larva L3 12hr old    34 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    235 white prepupae new    259 white prepupae 12hr    181 white prepupae 24hr    169 pupae 2d postWPP    115 pupae 3d postWPP    76 pupae 4d postWPP    83 adult male 01day    112 adult male 05day    120 adult male 30day    123 adult female 01day    84 adult female 05day    145 adult female 30day    140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (200) embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2  (43) larva L3 12hr old  (34) larva L3 puffstage 1-2  (88) larva L3 puffstage 3-6  (151) larva L3 puffstage 7-9  (235) white prepupae new  (259) white prepupae 12hr  (181) white prepupae 24hr  (169) pupae 2d postWPP  (115) pupae 3d postWPP  (76) pupae 4d postWPP  (83) adult male 01day  (112) adult male 05day  (120) adult male 30day  (123) adult female 01day  (84) adult female 05day  (145) adult female 30day  (140) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (200) embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2    43 larva L3 12hr old    34 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6  (151) larva L3 puffstage 7-9  (235) white prepupae new  (259) white prepupae 12hr  (181) white prepupae 24hr  (169) pupae 2d postWPP  (115) pupae 3d postWPP    76 pupae 4d postWPP    83 adult male 01day  (112) adult male 05day  (120) adult male 30day  (123) adult female 01day    84 adult female 05day  (145) adult female 30day  (140) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    200 embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2    43 larva L3 12hr old    34 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    235 white prepupae new    259 white prepupae 12hr    181 white prepupae 24hr    169 pupae 2d postWPP    115 pupae 3d postWPP    76 pupae 4d postWPP    83 adult male 01day    112 adult male 05day    120 adult male 30day    123 adult female 01day    84 adult female 05day    145 adult female 30day    140 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    200 embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2    43 larva L3 12hr old    34 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    235 white prepupae new    259 white prepupae 12hr    181 white prepupae 24hr    169 pupae 2d postWPP    115 pupae 3d postWPP    76 pupae 4d postWPP    83 adult male 01day    112 adult male 05day    120 adult male 30day    123 adult female 01day    84 adult female 05day    145 adult female 30day    140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (200) embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2  (43) larva L3 12hr old  (34) larva L3 puffstage 1-2  (88) larva L3 puffstage 3-6  (151) larva L3 puffstage 7-9  (235) white prepupae new  (259) white prepupae 12hr  (181) white prepupae 24hr  (169) pupae 2d postWPP  (115) pupae 3d postWPP  (76) pupae 4d postWPP  (83) adult male 01day  (112) adult male 05day  (120) adult male 30day  (123) adult female 01day  (84) adult female 05day  (145) adult female 30day  (140) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (200) embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2    43 larva L3 12hr old    34 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6  (151) larva L3 puffstage 7-9  (235) white prepupae new  (259) white prepupae 12hr  (181) white prepupae 24hr  (169) pupae 2d postWPP  115 pupae 3d postWPP    76 pupae 4d postWPP    83 adult male 01day  112 adult male 05day  120 adult male 30day  123 adult female 01day    84 adult female 05day  (145) adult female 30day  140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    200 embryo 02-04hr    15 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    8 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    12 larva L2    43 larva L3 12hr old    34 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    235 white prepupae new    259 white prepupae 12hr    181 white prepupae 24hr    169 pupae 2d postWPP    115 pupae 3d postWPP    76 pupae 4d postWPP    83 adult male 01day    112 adult male 05day    120 adult male 30day    123 adult female 01day    84 adult female 05day    145 adult female 30day    140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    168 embryonic 1182-4H    139 embryonic GM2    236 embryonic Kc167    186 embryonic S1    265 embryonic S3    202 leg disc CME L1    215 wing disc CME-W2    247 wing disc ML-DmD8    160 wing disc ML-DmD9    193 wing disc ML-DmD16-c3    128 wing disc ML-DmD21    115 wing disc ML-DmD32    168 haltere disc ML-DmD17-c3    192 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    194 mixed discs ML-DmD4-c1    111 CNS ML-DmBG1-c1    194 CNS ML-DmBG2-c2    238 tumorous blood cells mbn2    226 ovary fGS/OSS    113 ovary OSC    167 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (168) embryonic 1182-4H  (139) embryonic GM2  (236) embryonic Kc167  (186) embryonic S1  (265) embryonic S3  (202) leg disc CME L1  (215) wing disc CME-W2  (247) wing disc ML-DmD8  (160) wing disc ML-DmD9  (193) wing disc ML-DmD16-c3  (128) wing disc ML-DmD21  (115) wing disc ML-DmD32  (168) haltere disc ML-DmD17-c3  (192) eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (194) mixed discs ML-DmD4-c1  (111) CNS ML-DmBG1-c1  (194) CNS ML-DmBG2-c2  (238) tumorous blood cells mbn2  (226) ovary fGS/OSS  (113) ovary OSC  (167) ovary OSS  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (168) embryonic 1182-4H  (139) embryonic GM2  (236) embryonic Kc167  (186) embryonic S1  (265) embryonic S3  (202) leg disc CME L1  (215) wing disc CME-W2  (247) wing disc ML-DmD8  (160) wing disc ML-DmD9  (193) wing disc ML-DmD16-c3  (128) wing disc ML-DmD21  (115) wing disc ML-DmD32  (168) haltere disc ML-DmD17-c3  (192) eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (194) mixed discs ML-DmD4-c1  (111) CNS ML-DmBG1-c1  (194) CNS ML-DmBG2-c2  (238) tumorous blood cells mbn2  (226) ovary fGS/OSS  (113) ovary OSC  (167) ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    168 embryonic 1182-4H    139 embryonic GM2    236 embryonic Kc167    186 embryonic S1    265 embryonic S3    202 leg disc CME L1    215 wing disc CME-W2    247 wing disc ML-DmD8    160 wing disc ML-DmD9    193 wing disc ML-DmD16-c3    128 wing disc ML-DmD21    115 wing disc ML-DmD32    168 haltere disc ML-DmD17-c3    192 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    194 mixed discs ML-DmD4-c1    111 CNS ML-DmBG1-c1    194 CNS ML-DmBG2-c2    238 tumorous blood cells mbn2    226 ovary fGS/OSS    113 ovary OSC    167 ovary OSS    49 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    168 embryonic 1182-4H    139 embryonic GM2    236 embryonic Kc167    186 embryonic S1    265 embryonic S3    202 leg disc CME L1    215 wing disc CME-W2    247 wing disc ML-DmD8    160 wing disc ML-DmD9    193 wing disc ML-DmD16-c3    128 wing disc ML-DmD21    115 wing disc ML-DmD32    168 haltere disc ML-DmD17-c3    192 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    194 mixed discs ML-DmD4-c1    111 CNS ML-DmBG1-c1    194 CNS ML-DmBG2-c2    238 tumorous blood cells mbn2    226 ovary fGS/OSS    113 ovary OSC    167 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (168) embryonic 1182-4H  (139) embryonic GM2  (236) embryonic Kc167  (186) embryonic S1  (265) embryonic S3  (202) leg disc CME L1  (215) wing disc CME-W2  (247) wing disc ML-DmD8  (160) wing disc ML-DmD9  (193) wing disc ML-DmD16-c3  (128) wing disc ML-DmD21  (115) wing disc ML-DmD32  (168) haltere disc ML-DmD17-c3  (192) eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (194) mixed discs ML-DmD4-c1  (111) CNS ML-DmBG1-c1  (194) CNS ML-DmBG2-c2  (238) tumorous blood cells mbn2  (226) ovary fGS/OSS  (113) ovary OSC  (167) ovary OSS  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (168) embryonic 1182-4H  139 embryonic GM2  (236) embryonic Kc167  (186) embryonic S1  (265) embryonic S3  (202) leg disc CME L1  (215) wing disc CME-W2  (247) wing disc ML-DmD8  (160) wing disc ML-DmD9  (193) wing disc ML-DmD16-c3  128 wing disc ML-DmD21  115 wing disc ML-DmD32  (168) haltere disc ML-DmD17-c3  (192) eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (194) mixed discs ML-DmD4-c1  111 CNS ML-DmBG1-c1  (194) CNS ML-DmBG2-c2  (238) tumorous blood cells mbn2  (226) ovary fGS/OSS  113 ovary OSC  (167) ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    168 embryonic 1182-4H    139 embryonic GM2    236 embryonic Kc167    186 embryonic S1    265 embryonic S3    202 leg disc CME L1    215 wing disc CME-W2    247 wing disc ML-DmD8    160 wing disc ML-DmD9    193 wing disc ML-DmD16-c3    128 wing disc ML-DmD21    115 wing disc ML-DmD32    168 haltere disc ML-DmD17-c3    192 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    194 mixed discs ML-DmD4-c1    111 CNS ML-DmBG1-c1    194 CNS ML-DmBG2-c2    238 tumorous blood cells mbn2    226 ovary fGS/OSS    113 ovary OSC    167 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    120 cold shock, 4-day adult    107 heat shock, 4-day adult    155 Cadmium 50 mM 6 hrs, larvae L3    121 Cadmium 50 mM 12 hrs, larvae L3    278 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    273 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    81 Zinc 4.5 mM 48 hrs, 4-day adult    85 Ethanol 2.5% 3 hrs, larvae L3    285 Ethanol 5% 3 hrs, larvae L3    108 Ethanol 10% 3 hrs, larvae L3    113 Caffeine 1.5 mg/ml 4 hrs, larvae L3    146 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    254 Caffeine 25 mg/ml 48 hrs, 4-day adult    94 Paraquat 5 mM 48 hrs, 4-day adult    199 Paraquat 10 mM 48 hrs, 4-day adult    230 Rotenone 2 μg 12 hrs, larvae L3    135 Rotenone 8 μg 12 hrs, larvae L3    107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (120) cold shock, 4-day adult  (107) heat shock, 4-day adult  (155) Cadmium 50 mM 6 hrs, larvae L3  (121) Cadmium 50 mM 12 hrs, larvae L3  (278) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (273) Copper 0.5 mM 12 hrs, larvae L3  (73) Copper 15 mM 48 hrs, 4-day adult  (119) Zinc 5 mM 12 hrs, larvae L3  (81) Zinc 4.5 mM 48 hrs, 4-day adult  (85) Ethanol 2.5% 3 hrs, larvae L3  (285) Ethanol 5% 3 hrs, larvae L3  (108) Ethanol 10% 3 hrs, larvae L3  (113) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (146) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (254) Caffeine 25 mg/ml 48 hrs, 4-day adult  (94) Paraquat 5 mM 48 hrs, 4-day adult  (199) Paraquat 10 mM 48 hrs, 4-day adult  (230) Rotenone 2 μg 12 hrs, larvae L3  (135) Rotenone 8 μg 12 hrs, larvae L3  (107) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (120) cold shock, 4-day adult  107 heat shock, 4-day adult  (155) Cadmium 50 mM 6 hrs, larvae L3  (121) Cadmium 50 mM 12 hrs, larvae L3  (278) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (273) Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult  (119) Zinc 5 mM 12 hrs, larvae L3    81 Zinc 4.5 mM 48 hrs, 4-day adult    85 Ethanol 2.5% 3 hrs, larvae L3  (285) Ethanol 5% 3 hrs, larvae L3  (108) Ethanol 10% 3 hrs, larvae L3  (113) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (146) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (254) Caffeine 25 mg/ml 48 hrs, 4-day adult    94 Paraquat 5 mM 48 hrs, 4-day adult  (199) Paraquat 10 mM 48 hrs, 4-day adult  (230) Rotenone 2 μg 12 hrs, larvae L3  (135) Rotenone 8 μg 12 hrs, larvae L3  107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    120 cold shock, 4-day adult    107 heat shock, 4-day adult    155 Cadmium 50 mM 6 hrs, larvae L3    121 Cadmium 50 mM 12 hrs, larvae L3    278 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    273 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    81 Zinc 4.5 mM 48 hrs, 4-day adult    85 Ethanol 2.5% 3 hrs, larvae L3    285 Ethanol 5% 3 hrs, larvae L3    108 Ethanol 10% 3 hrs, larvae L3    113 Caffeine 1.5 mg/ml 4 hrs, larvae L3    146 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    254 Caffeine 25 mg/ml 48 hrs, 4-day adult    94 Paraquat 5 mM 48 hrs, 4-day adult    199 Paraquat 10 mM 48 hrs, 4-day adult    230 Rotenone 2 μg 12 hrs, larvae L3    135 Rotenone 8 μg 12 hrs, larvae L3    107 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    120 cold shock, 4-day adult    107 heat shock, 4-day adult    155 Cadmium 50 mM 6 hrs, larvae L3    121 Cadmium 50 mM 12 hrs, larvae L3    278 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    273 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    81 Zinc 4.5 mM 48 hrs, 4-day adult    85 Ethanol 2.5% 3 hrs, larvae L3    285 Ethanol 5% 3 hrs, larvae L3    108 Ethanol 10% 3 hrs, larvae L3    113 Caffeine 1.5 mg/ml 4 hrs, larvae L3    146 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    254 Caffeine 25 mg/ml 48 hrs, 4-day adult    94 Paraquat 5 mM 48 hrs, 4-day adult    199 Paraquat 10 mM 48 hrs, 4-day adult    230 Rotenone 2 μg 12 hrs, larvae L3    135 Rotenone 8 μg 12 hrs, larvae L3    107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (120) cold shock, 4-day adult  (107) heat shock, 4-day adult  (155) Cadmium 50 mM 6 hrs, larvae L3  (121) Cadmium 50 mM 12 hrs, larvae L3  (278) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (273) Copper 0.5 mM 12 hrs, larvae L3  (73) Copper 15 mM 48 hrs, 4-day adult  (119) Zinc 5 mM 12 hrs, larvae L3  (81) Zinc 4.5 mM 48 hrs, 4-day adult  (85) Ethanol 2.5% 3 hrs, larvae L3  (285) Ethanol 5% 3 hrs, larvae L3  (108) Ethanol 10% 3 hrs, larvae L3  (113) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (146) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (254) Caffeine 25 mg/ml 48 hrs, 4-day adult  (94) Paraquat 5 mM 48 hrs, 4-day adult  (199) Paraquat 10 mM 48 hrs, 4-day adult  (230) Rotenone 2 μg 12 hrs, larvae L3  (135) Rotenone 8 μg 12 hrs, larvae L3  (107) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  120 cold shock, 4-day adult  107 heat shock, 4-day adult  (155) Cadmium 50 mM 6 hrs, larvae L3  121 Cadmium 50 mM 12 hrs, larvae L3  (278) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (273) Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult  119 Zinc 5 mM 12 hrs, larvae L3    81 Zinc 4.5 mM 48 hrs, 4-day adult    85 Ethanol 2.5% 3 hrs, larvae L3  (285) Ethanol 5% 3 hrs, larvae L3  108 Ethanol 10% 3 hrs, larvae L3  113 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (146) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (254) Caffeine 25 mg/ml 48 hrs, 4-day adult    94 Paraquat 5 mM 48 hrs, 4-day adult  (199) Paraquat 10 mM 48 hrs, 4-day adult  (230) Rotenone 2 μg 12 hrs, larvae L3  135 Rotenone 8 μg 12 hrs, larvae L3  107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    120 cold shock, 4-day adult    107 heat shock, 4-day adult    155 Cadmium 50 mM 6 hrs, larvae L3    121 Cadmium 50 mM 12 hrs, larvae L3    278 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    273 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    81 Zinc 4.5 mM 48 hrs, 4-day adult    85 Ethanol 2.5% 3 hrs, larvae L3    285 Ethanol 5% 3 hrs, larvae L3    108 Ethanol 10% 3 hrs, larvae L3    113 Caffeine 1.5 mg/ml 4 hrs, larvae L3    146 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    254 Caffeine 25 mg/ml 48 hrs, 4-day adult    94 Paraquat 5 mM 48 hrs, 4-day adult    199 Paraquat 10 mM 48 hrs, 4-day adult    230 Rotenone 2 μg 12 hrs, larvae L3    135 Rotenone 8 μg 12 hrs, larvae L3    107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH02396 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010288 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4265-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Uchf00912 viable, with Scer\GAL4pnr-MD237 UchGD11265 Sterility Allele fertile Uchf00912 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Uch Class Mutagen Stocks Known lesion Uchf00912 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Uch Class Mutagen Stocks Known lesion UchGD11265 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes UchKK101723 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes UchNIG.4265R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)dp-79b (Iida and Lilly, 2004) Df(2L)Exel6007 (Ryder, 2004.4.26) Df(2L)Exel7009 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11265} NA P{KK101723} NA P{NIG.4265R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Uchf00912 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
ubiquitin thiolesterase activity inferred from direct assay (Zhang et al., 1993)
Biological Process
CV term Evidence References
protein deubiquitination inferred from direct assay (Zhang et al., 1993)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ubiquitin thiolesterase activity non-traceable author statement (Zhang, 1992.12.4, Swiss-Prot Project Members, 1994.2.1)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001578 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Uch - Akap200 experimental knowledge based (Guruharsha et al., 2011) Uch - Ald experimental knowledge based (Guruharsha et al., 2011) Uch - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Uch - AnxB9 experimental knowledge based (Guruharsha et al., 2011) Uch - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG10638 experimental knowledge based (Guruharsha et al., 2011) Uch - CG10863 experimental knowledge based (Guruharsha et al., 2011) Uch - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG13887 experimental knowledge based (Guruharsha et al., 2011) Uch - CG14715 experimental knowledge based (Guruharsha et al., 2011) Uch - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG1707 experimental knowledge based (Guruharsha et al., 2011) Uch - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG2852 experimental knowledge based (Guruharsha et al., 2011) Uch - CG2862 experimental knowledge based (Guruharsha et al., 2011) Uch - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG4598 experimental knowledge based (Guruharsha et al., 2011) Uch - CG5174 experimental knowledge based (Guruharsha et al., 2011) Uch - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG6084 experimental knowledge based (Guruharsha et al., 2011) Uch - CG6180 experimental knowledge based (Guruharsha et al., 2011) Uch - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG7430 experimental knowledge based (Guruharsha et al., 2011) Uch - CG7911 experimental knowledge based (Guruharsha et al., 2011) Uch - CG7924 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - CG8036 experimental knowledge based (Guruharsha et al., 2011) Uch - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - Chd64 experimental knowledge based (Guruharsha et al., 2011) Uch - Crc experimental knowledge based (Guruharsha et al., 2011) Uch - Df31 experimental knowledge based (Guruharsha et al., 2011) Uch - Eb1 experimental knowledge based (Guruharsha et al., 2011) Uch - EndoGI experimental knowledge based (Guruharsha et al., 2011) Uch - Eno experimental knowledge based (Guruharsha et al., 2011) Uch - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Uch - Fim experimental knowledge based (Guruharsha et al., 2011) Uch - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Uch - Gdi experimental knowledge based (Guruharsha et al., 2011) Uch - GstE6 experimental knowledge based (Guruharsha et al., 2011) Uch - GstO3 experimental knowledge based (Guruharsha et al., 2011) Uch - GstT1 experimental knowledge based (Guruharsha et al., 2011) Uch - Hop experimental knowledge based (Guruharsha et al., 2011) Uch - Inos experimental knowledge based (Guruharsha et al., 2011) Uch - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Uch - Moe experimental knowledge based (Guruharsha et al., 2011) Uch - Nacα experimental knowledge based (Guruharsha et al., 2011) Uch - Nlp experimental knowledge based (Guruharsha et al., 2011) Uch - PHGPx experimental knowledge based (Guruharsha et al., 2011) Uch - Pdi experimental knowledge based (Guruharsha et al., 2011) Uch - Pgd experimental knowledge based (Guruharsha et al., 2011) Uch - Pgk experimental knowledge based (Guruharsha et al., 2011) Uch - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - Prosα1 experimental knowledge based (Guruharsha et al., 2011) Uch - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Uch - RhoGDI experimental knowledge based (Guruharsha et al., 2011) Uch - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Uch - Sh3β experimental knowledge based (Guruharsha et al., 2011) Uch - Sod2 experimental knowledge based (Guruharsha et al., 2011) Uch - TER94 experimental knowledge based (Guruharsha et al., 2011) Uch - Trx-2 experimental knowledge based (Guruharsha et al., 2011) Uch - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - awd experimental knowledge based (Guruharsha et al., 2011) Uch - bys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - capt experimental knowledge based (Guruharsha et al., 2011) Uch - chic experimental knowledge based (Guruharsha et al., 2011) Uch - cib experimental knowledge based (Guruharsha et al., 2011) Uch - eEF1δ experimental knowledge based (Guruharsha et al., 2011) Uch - fabp experimental knowledge based (Guruharsha et al., 2011) Uch - fax experimental knowledge based (Guruharsha et al., 2011) Uch - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Uch - mus209 experimental knowledge based (Guruharsha et al., 2011) Uch - regucalcin experimental knowledge based (Guruharsha et al., 2011) Uch - scf experimental knowledge based (Guruharsha et al., 2011) Uch - scu experimental knowledge based (Guruharsha et al., 2011) Uch - sel experimental knowledge based (Guruharsha et al., 2011) Uch - smt3 experimental knowledge based (Guruharsha et al., 2011) Uch - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Uch allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59626 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010288 DroID - A comprehensive database of gene and protein interactions. • FBgn0010288 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33397
Orthologs
OrthoDB Orthologs (73) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QZ86B Dipteran inclusive ortholog search EOG62V8RC Insect inclusive ortholog search EOG6TQK67 Arthropod inclusive ortholog search EOG6K6DMC Metazoa inclusive ortholog search EOG644ZDW
Orthologs in Drosophila Species (EOG6QZ86B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Uch     Drosophila simulans   Dsim\GD22865 Y   Drosophila sechellia   Dsec\GM18256 Y   Drosophila erecta   Dere\GG24548 Y   Drosophila yakuba   Dyak\GE15202 Y   Drosophila ananassae   Dana\GF15299 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18067 Y   Drosophila persimilis   Dper\GL19416 Y   Drosophila willistoni   Dwil\GK15133 Y   Drosophila virilis   Dvir\GJ17211 Y   Drosophila mojavensis   Dmoj\GI16929 Y   Drosophila grimshawi   Dgri\GH11470 Y
Orthologs in non-Drosophila Dipterans (EOG62V8RC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012807   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013052   Anopheles gambiae Malaria mosquito  Agam\AGAP012113   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016441
Orthologs in non-Dipteran Insects (EOG6TQK67)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Uch   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014887   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17649   Atta cephalotes Leafcutter ant  Acep\ACEP15353   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21287   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19584   Linepithema humile Argentine ant  Lhum\LH11212   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15363   Solenopsis invicta Red fire ant  Sinv\SINV10234   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006329   Bombyx mori Silkmoth  Bmor\BGIBMGA002640   Pediculus humanus Human body louse  Phum\PHUM022230   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07923   Tribolium castaneum Red flour beetle  Tcas\TC003809
Orthologs in non-Insect Arthropods (EOG6K6DMC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_188571   Ixodes scapularis Deer tick  Isca\ISCW023394
Orthologs in non-Arthropod Metazoa (EOG644ZDW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ubh-3   Caenorhabditis elegans Nematode  Cele\ubh-1   Caenorhabditis elegans Nematode  Cele\ubh-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025114gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020456gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016616gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012059gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020933gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015480gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012061gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010012gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022342gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005976gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001206gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016986gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019767gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025961gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008460gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014292gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001143gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023073gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027773gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000476gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026976gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000499gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013050gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017265gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020183gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022388gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000327gn   Danio rerio Zebrafish  Drer\uchl3   Xenopus tropicalis Western clawed frog  Xtro\uchl1   Xenopus tropicalis Western clawed frog  Xtro\uchl3   Gallus gallus Domestic chicken  Ggal\UCHL3   Gallus gallus Domestic chicken  Ggal\UCHL1   Mus musculus House mouse  Mmus\Uchl1   Mus musculus House mouse  Mmus\Uchl3   Mus musculus House mouse  Mmus\Uchl4   Rattus norvegicus Norway rat  Rnor\Uchl3   Rattus norvegicus Norway rat  Rnor\Uchl1   Homo sapiens Human  Hsap\UCHL3
Human Orthologs (1)
Gene OMIM HGNC Hsap\UCHL3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22865 Drosophila sechellia Dsec\GM18256 Drosophila erecta Dere\GG24548 Drosophila yakuba Dyak\GE15202 Drosophila ananassae Dana\GF15299 Drosophila pseudoobscura pseudoobscura Dpse\GA18067 Drosophila persimilis Dper\GL19416 Drosophila willistoni Dwil\GK15133 Drosophila virilis Dvir\GJ17211 Drosophila mojavensis Dmoj\GI16929 Drosophila grimshawi Dgri\GH11470
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	18390 w1118; PBac{WH}Uchf00912
Harvard	- PBac{WH}Uchf00912
VDRC	v103614 P{KK101723}VIE-260B v26468 w1118; P{GD11265}v26468 v26469 w1118; P{GD11265}v26469/TM3
Genomic Clones ( 1 )
	BACR01K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02396
Other clones	DPiM_GH02396
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07795 AT08910 AT10207 AT13680 AT15145 GH13115 GH25235 GM17156 GM27874 GM28642 HL05693 LP23149 RE61647 RE62747 RH49831 SD09014 SD23680 SD25680
Other clones	bs06c02 bs15g07 bs21c09 bs30d05 bs58a02 Dmel_dig_008035_0596_2012 Dmel_neb_006752_0841_3416 Dmel_neb_010818_0566_2164 Dmel_neb_011006_0114_0876 Dmel_neb_014355_0842_1622 EC27937 EK019107 EK111128 EK112715 EK172852 EK199349 EK223929 EK237161 EN04232 FGH102C11 FGM221D04 RP003141973 RP003195676 RP003362946 RP003398276 RP003530208
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010288 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33397
Antibody Information
	polyclonal (Thao et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Uch CG4265 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Identified via an enhancer trap element reflecting the expression in nurse cells. (Zhang et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057592 NM_001201752 NM_001272986 RefSeq (Proteins) • NP_476940 NP_001188681 NP_001259915 DDBJ / EMBL / GenBank • AAD38575 AAF51291 AC004340 ADV36932 AF145600 AGB92452 AI062998 AI135399 AI401858 AI405282 AI542601 AI945696 AI946134 AI946760 BE662016 CAA49358 CAA49359 X69678 X69679 Entrez Gene - A searchable database of RefSeq genes. • 33397 UniProtKB/Swiss-Prot • P35122
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 (IPR001578) MEROPS - An information resource for peptidases and the proteins that inhibit them • C12.001 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH02396
Linkouts
	BioGRID - A database of protein and genetic interactions • 59626 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010288 DroID - A comprehensive database of gene and protein interactions. • FBgn0010288 DRSC - Results from RNAi screens. • FBgn0010288 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010288 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4265-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010288 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33397 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33397 modMine - Data generated by the modENCODE project. • FBgn0010288
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG4265 (Zhang et al., 2012, Keleman et al., 2009.8.5, Hughes et al., 2008, Tsou et al., 2012, Puri et al., 2008, Lundgren et al., 2005) UBL (Chung and Baek, 1999) UCH (Roff et al., 1996, Mendoza et al., 2003, Jin et al., 2009) uch (Rubin, 1999.4.23) Uch (Junion et al., 2007, Tsou et al., 2012, Cunha et al., 2010, Japanese National Institute of Genetics, 2012.5.21) UCH-D (Layfield et al., 1999, Holzl et al., 2000) uch-D (Zhang et al., 1993) Uch-D (Lundgren et al., 2005) UCH-D19 (Ventadour et al., 2007)
Name Synonym	ubiquitin carboxyl terminal hydrolase (Zhang, 1992.12.4, Zhang, 1992.12.4) Ubiquitin carboxy-terminal hydrolase (Jin et al., 2009) ubiquitin C-terminal hydrolase (Lundgren et al., 2005)
Secondary FlyBase IDs
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Palgi et al., 2012, BMC Genomics 13: 134 Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. [FBrf0218515] Thao et al., 2012, Cell Tissue Res. 348(3): 453--463 Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster. [FBrf0218474] Tsou et al., 2012, PLoS ONE 7(8): e43112 Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes. [FBrf0219256] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...