JNKK, MKK7, hp, hem, HEP/MKK7
a serine/threonine protein kinase (MapKK/JunKK) involved in dorsal closure - involved in the Jun-N-terminal kinase pathway by phosphorylating Basket - required for the correct differentiation of epithelia
Gene model reviewed during 6.02
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Double stop-codon suppression (UGA, UGA) postulated; FBrf0243886.
Gene model reviewed during 6.32
6.0 (northern blot)
MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hep using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\hep in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG4353 and CG2190 merged as CG4353 in release 3 of the genome annotation.
Injection of dsRNA targeting hep results in 11.5% embryos showing a dorsal open phenotype.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
hep is necessary for actin-cable assembly and actin-based cell process formation in leading edge cells during dorsal closure.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
hep is essential for the correct morphogenesis of the dorsal appendage and micropyle.
hep and the JNK pathway are required for correct morphogenesis of the imaginal discs.
Candidate gene for posterior lobe area quantitative trait locus.
Show no or weak ommatidial precursor polarity phenotypes in imaginal tissues.
The JNK pathway (which includes hep) is required for thorax closure during metamorphosis.
hep is required for normal dpp expression in the leading edge during dorsal closure. puc is both a repressor and a target of hep function in the leading edge. The combined and antagonistic functions of hep and puc maintain appropriate levels of puc and dpp activities in migrating epithelia during dorsal closure. These results indicate a leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.
The JNK pathway is conserved between vertebrates and Drosophila and is involved in controlling cell morphogenesis in Drosophila.