FlyBase Gene Report: Dmel\hep

General Information

Symbol

Dmel\hep

Species

D. melanogaster

Name

hemipterous

Annotation Symbol

CG4353

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010303

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

hemipterous (hep) encodes a serine/threonine protein kinase involved in the Jun-N-terminal kinase pathway by phosphorylating the product of bsk. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

JNKK, MKK7, hp, Hemipterus, MAPKK

Key Links

Genomic Location

Cytogenetic map

11D10-11D10

Sequence location

X:13,079,205..13,090,434 [-]

Recombination map

1-41

RefSeq locus

NC_004354 REGION:13079205..13090434

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (45 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

enables JUN kinase kinase activity

inferred from direct assay

(Sluss et al., 1996)

enables MAP-kinase scaffold activity

inferred from direct assay

(assigned by UniProt )

(Taru et al., 2002)

enables protein binding

inferred from physical interaction with FLYBASE:Strip; FB:FBgn0035437

(La Marca et al., 2019)

inferred from physical interaction with FLYBASE:Cka; FB:FBgn0044323

(La Marca et al., 2019, Chen et al., 2002)

enables protein kinase activity

inferred from direct assay

(Glise et al., 1995)

enables protein kinase binding

inferred from physical interaction with UniProtKB:Q9W0K0

(assigned by UniProt )

(Taru et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (38 terms)

Terms Based on Experimental Evidence (37 terms)

CV Term

Evidence

References

involved_in antibacterial humoral response

inferred from direct assay

(Sluss et al., 1996)

involved_in axon extension

inferred from mutant phenotype

(Srahna et al., 2006)

involved_in axon guidance

inferred from direct assay

(Soares et al., 2014)

involved_in basement membrane disassembly

inferred from mutant phenotype

(Srivastava et al., 2007)

involved_in carbohydrate homeostasis

inferred from mutant phenotype

(Hull-Thompson et al., 2009)

involved_in cellular response to arsenic-containing substance

inferred from mutant phenotype

(Ryabinina et al., 2006)

involved_in cellular response to cadmium ion

inferred from mutant phenotype

(Ryabinina et al., 2006)

involved_in chorion micropyle formation

inferred from mutant phenotype

(Suzanne et al., 2001)

involved_in chorion-containing eggshell pattern formation

inferred from mutant phenotype

(Suzanne et al., 2001)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Wang et al., 2003)

involved_in dorsal appendage formation

inferred from mutant phenotype

(Suzanne et al., 2001)

involved_in dorsal closure, spreading of leading edge cells

inferred from mutant phenotype

(Glise et al., 1995)

involved_in dorsal closure

inferred from mutant phenotype

(Thomas et al., 2009, Kaltschmidt et al., 2002)

inferred from mutant phenotype

(assigned by UniProt )

(Rousset et al., 2010)

involved_in engulfment of apoptotic cell

inferred from mutant phenotype

(Etchegaray et al., 2012)

involved_in imaginal disc eversion

inferred from mutant phenotype

(Srivastava et al., 2007, Pastor-Pareja et al., 2004)

involved_in imaginal disc fusion, thorax closure

inferred from mutant phenotype

(Thomas et al., 2009, Ishimaru et al., 2004)

inferred from genetic interaction with FLYBASE:Rab30; FB:FBgn0031882

(Thomas et al., 2009)

inferred from genetic interaction with FLYBASE:slpr; FB:FBgn0030018

(Baril et al., 2009)

involved_in imaginal disc fusion

inferred from mutant phenotype

(Pastor-Pareja et al., 2004)

involved_in imaginal disc-derived male genitalia morphogenesis

inferred from mutant phenotype

(assigned by UniProt )

(Rousset et al., 2010)

involved_in intestinal stem cell homeostasis

inferred from mutant phenotype

(Wang et al., 2014)

involved_in JNK cascade

inferred from genetic interaction with FLYBASE:Mkk4; FB:FBgn0024326

(Geuking et al., 2009)

inferred from direct assay

(Sluss et al., 1996)

inferred from mutant phenotype

(Ryabinina et al., 2006, Ishimaru et al., 2004, Riesgo-Escovar et al., 1996)

involved_in melanization defense response

inferred from mutant phenotype

(Bidla et al., 2007)

involved_in neuron development

inferred from mutant phenotype

(Rallis et al., 2010)

involved_in ovarian follicle cell development

inferred from mutant phenotype

(Jordan et al., 2006)

involved_in peptidoglycan recognition protein signaling pathway

inferred from mutant phenotype

(Valanne et al., 2007, Silverman et al., 2003, Boutros et al., 2002)

inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323

(Delaney et al., 2006)

involved_in positive regulation of actin filament bundle assembly

inferred from mutant phenotype

(Kaltschmidt et al., 2002)

involved_in positive regulation of autophagy

inferred from mutant phenotype

(Wu et al., 2009)

involved_in positive regulation of border follicle cell migration

inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006

(Mathieu et al., 2007)

acts_upstream_of positive regulation of cell death

inferred from mutant phenotype

(Sun et al., 2019, Wang et al., 2018, Ma et al., 2014, Ma et al., 2012, Kanda et al., 2011, Geuking et al., 2005)

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Geuking et al., 2009, Igaki et al., 2002)

inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323

(Xue et al., 2007)

involved_in positive regulation of filopodium assembly

inferred from mutant phenotype

(Kaltschmidt et al., 2002)

involved_in positive regulation of gene expression

inferred from mutant phenotype

(assigned by UniProt )

(Srivastava and Dong, 2015, Rousset et al., 2010)

involved_in positive regulation of lamellipodium assembly

inferred from mutant phenotype

(Kaltschmidt et al., 2002)

involved_in positive regulation of transcription, DNA-templated

inferred from mutant phenotype

(Wu et al., 2009)

involved_in response to heat

inferred from mutant phenotype

(Gonda et al., 2012, Karpac et al., 2009)

involved_in triglyceride homeostasis

inferred from mutant phenotype

(Hull-Thompson et al., 2009)

involved_in tumor necrosis factor-mediated signaling pathway

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Sun et al., 2019, Geuking et al., 2009, Igaki et al., 2002)

inferred from mutant phenotype

(Sun et al., 2019, Wang et al., 2018, Ma et al., 2014, Ma et al., 2012, Kanda et al., 2011, Geuking et al., 2005)

inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323

(Xue et al., 2007)

involved_in vascular endothelial growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006

(Ishimaru et al., 2004)

involved_in wound healing

inferred from mutant phenotype

(Bosch et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Rallis et al., 2010)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

STE7 MAP KINASE KINASES

Pathway (FlyBase)

Pvr Signaling Pathway Core Components

Imd Signaling Pathway Core Components

TNFα-Eiger Signaling Pathway Core Components

Protein Family (UniProt)

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (Q23977)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

hemipterous (hep) encodes a serine/threonine protein kinase involved in the Jun-N-terminal kinase pathway by phosphorylating the product of bsk. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

STE7 MAP KINASE KINASES -: STE7 MAP kinase kinases (MAPKKs) belong to the STE7 subfamily and are serine/threonine kinases that phosphorylate MAP kinases in MAPK signalling cascades. MAPKKs are activated by MAP kinase kinase kinases (MAPKKKs). (Adapted from FBrf0225276.)

Pathway (FlyBase)

Pvr Signaling Pathway Core Components -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Imd Signaling Pathway Core Components -: The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
TNFα-Eiger Signaling Pathway Core Components -: The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)

Protein Function (UniProtKB)

Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis.

(UniProt, Q23977)

Summary (Interactive Fly)

a serine/threonine protein kinase (MapKK/JunKK) involved in dorsal closure - involved in the Jun-N-terminal kinase pathway by phosphorylating Basket - required for the correct differentiation of epithelia

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\hep for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q23977)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 6.02

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Double stop-codon suppression (UGA, UGA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2020, Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

hep-RA

FBtr0073747

NM_167346

4893

1178

hep-RC

FBtr0073748

NM_078587

2738

492

hep-RD

FBtr0330396

NM_001272571

5344

1162

hep-RE

FBtr0330397

NM_001272572

5689

492

hep-RF

FBtr0340303

NM_001298253

5344

1153

hep-RG

FBtr0479992

NM_001382110

4893

1187

hep-RH

FBtr0479993

NM_001382111

4893

1294

Additional Transcript Data and Comments

Reported size (kB)

6.0 (northern blot)

(Glise et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

hep-PA

FBpp0073578

125.1

1178

10.05

FBpp0073579

53.1

492

9.19

FBpp0303422

123.2

1162

9.98

FBpp0303423

53.1

492

9.19

FBpp0309264

122.3

1153

9.98

FBpp0428279

126.1

1187

10.05

QJC18368

hep-PH

FBpp0428280

137.1

1294

9.56

QJC18369

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

492 aa isoforms: hep-PC, hep-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

487 (aa)

(Glise et al., 1995)

Comments

External Data

Post Translational Modification

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases.

Weakly autophosphorylated.

(UniProt, Q23977)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hep using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

hep_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Glise et al., 1995)

embryonic stage -- adult stage

(Glise et al., 1995)

Additional Descriptive Data

hep transcripts are detected throughout development on northern blots. In situ hybridization shows that they are homogeneously distributed throughout the embryo.

(Glise et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult mushroom body

• axon

(Rallis et al., 2010)

adult brain

(Rallis et al., 2010)

adult antennal lobe

(Rallis et al., 2010)

Additional Descriptive Data

hep protein is detected in mushroom body axons but is less prominent in mushroom body cell bodies. Additional signal is found throughout the adult brain including the antennal lobe.

(Rallis et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Rallis et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\hep in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\hep

View exonic expression by tissue for Dmel\hep

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010303

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32256/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010303

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010303

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010303

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4353

Flygut - An atlas of the Drosophila adult midgut

FBgn0010303

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 29 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of hep

Transgenic constructs containing regulatory region of hep

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(1)G24

(Paricio et al., 1999, Suzanne et al., 1999)

Df(1)H6

(Weber et al., 2000, Paricio et al., 1999, Suzanne et al., 1999)

Df(1)H49

(Suzanne et al., 1999)

Df(1)H81

(Suzanne et al., 1999)

Df(1)M56

(Suzanne et al., 1999)

Df(1)N12

(Glise et al., 1995)

Gene duplicated in

Dp(1;3)DC264

(Popodi et al., 2010-, Venken et al., 2010)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | partially | somatic clone, with Scer\GAL4^αTub84B.PL

hep^Act.UAS

lethal, with Scer\GAL4^69B

hep^Act.UAS

lethal | heat sensitive, with Scer\GAL4^GMR.PF

hep^CA.UAS

lethal | heat sensitive, with Scer\GAL4^vg.PU

hep^CA.UAS

lethal | pharate adult stage

hep^G0390

lethal | pupal stage

hep^G0390

lethal | recessive

lethal | recessive | rescuable maternal effect

hep¹

lethal - all die before end of P-stage | nutrition conditional, with Scer\GAL4^Tub.PU

hep^KK116295

lethal - all die before end of pupal stage

lethal - all die before end of pupal stage | recessive

lethal - all die during embryonic stage, with Scer\GAL4^69B

hep^Act.UAS

lethal - all die during embryonic stage, with Scer\GAL4^e22c

hep^CA.UAS

lethal - all die during embryonic stage | maternal effect | recessive

hep¹

lethal - all die during embryonic stage | recessive

hep¹

lethal - all die during embryonic stage | rescuable maternal effect

hep¹

lethal - all die during P-stage

hep^G0107

partially lethal - majority die, with Scer\GAL4^Tub.PU

hep^KK116295

partially lethal - majority die | female

hep^G0208

partially lethal - majority die | male

hep^G0208

partially lethal - majority die | recessive

hep^G0208

partially lethal - majority live | temperature conditional, with Scer\GAL4^GMR.PF

hep^CA.UAS

viable

hep¹

viable, with Scer\GAL4^Mef2.PR

hep^GD1461

viable, with Scer\GAL4^pnr-MD237

hep^GD1461

viable, with Scer\GAL4^tin.CΔ4

hep^GD1461

viable (with hep¹)

hep⁶⁹⁹

viable (with hep⁶⁹⁹)

hep¹

viable | female

hep¹

Sterility

Allele

female sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

hep^GL00089

Other Phenotypes

Allele

abnormal cell death, with Scer\GAL4^GR1

hep^CA.UAS

abnormal cell migration, with Scer\GAL4^ptc-559.1

hep^UAS.cUa

abnormal cell migration | third instar larval stage, with Scer\GAL4^ptc.PU

hep^UAS.cBa

abnormal cell number | adult stage, with Scer\GAL4^NP0001

hep^UAS.cBa

abnormal cell shape | embryonic stage, with Scer\GAL4^arm.PS

hep^Act.UAS

abnormal cell shape | third instar larval stage, with Scer\GAL4^pnr-MD237

hep^CA.UAS

abnormal heat stress response | adult stage

hep^Act.UAS

abnormal mitotic cell cycle | somatic clone

hep^r75

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^ato.3.6

hep^CA.UAS

abnormal neuroanatomy, with Scer\GAL4^P2.4.Pdf

hep^CA.UAS

abnormal neuroanatomy | larval stage, with Scer\GAL4^wor.PA

hep^CA.UAS

abnormal neuroanatomy | somatic clone

abnormal planar polarity, with Scer\GAL4^hs.2sev

abnormal size, with Scer\GAL4^GMR.PF

hep^CA.UAS

abnormal size, with Scer\GAL4^pnr-MD237

hep^UAS.cBa

abnormal size | adult stage, with Scer\GAL4^GMR.PF

abnormal size | adult stage, with Scer\GAL4^GMR.PU

hep^CA.UAS

abnormal stress response

hep¹

abnormal stress response, with Scer\GAL4^ppl.PP

hep^UAS.cBa

abnormal wound healing

hep^r75

abnormal wound healing, with Scer\GAL4^{elav.Switch.PO}

hep^CA.UAS

abnormal wound healing, with Scer\GAL4^{αTub84B.Switch.PK}

hep^CA.UAS

chemical resistant, with Scer\GAL4^arm.PS

hep^UAS.cBa

chemical resistant | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

hep^UAS.cBa

chemical sensitive

hep¹

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

hep^Act.UAS

decreased occurrence of cell division | embryonic stage 13, with Scer\GAL4^sim.PS

hep^CA.UAS

hyperplasia | adult stage, with Scer\GAL4^NP5130

hep^Act.UAS

increased cell death

hep^CA

increased cell death, with Scer\GAL4^GMR.PF

hep^CA.UAS

increased cell death, with Scer\GAL4^GMR.PU

increased cell death, with Scer\GAL4^pnr-MD237

hep^UAS.cBa

increased cell death, with Scer\GAL4^sev.PU

hep^CA.UAS

increased cell death | heat sensitive, with Scer\GAL4^en-e16E, Scer\GAL80^ts.αTub84B

hep^CA

increased cell death | somatic clone, with Scer\GAL4^GMR.PF

hep^CA.UAS

increased cell death | somatic clone, with Scer\GAL4^T80

hep^Act.UAS

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PF

hep^CA.UAS

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PU

hep^CA.UAS

increased cell death | third instar larval stage, with Scer\GAL4^ptc-559.1

increased cell death | third instar larval stage, with Scer\GAL4^ptc.PU

hep^UAS.cBa

increased cell death | third instar larval stage, with Scer\GAL4^sev.PU

hep^CA.UAS

increased cell number | adult stage, with Scer\GAL4^esg.PU

hep^UAS.cBa

increased cell number | adult stage, with Scer\GAL4^NP5130

hep^UAS.cBa

increased cell number | larval stage, with Scer\GAL4^He.PZ

hep^CA.UAS

increased cell number | larval stage, with Scer\GAL4^Hml.PG

hep^CA.UAS

increased cell size | third instar larval stage, with Scer\GAL4^pnr-MD237

hep^CA.UAS

increased occurrence of cell division, with Scer\GAL4^NP5130

hep^UAS.cBa

increased occurrence of cell division | adult stage, with Scer\GAL4^Dl-05151-G

hep^UAS.cBa

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

hep^UAS.cBa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

hep^UAS.cBa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

hep^UAS.cBa

long lived, with Scer\GAL4^elav-C155

hep^UAS.cBa

majority die during larval stage | nutrition conditional, with Scer\GAL4^Tub.PU

hep^KK116295

majority die during P-stage, with Scer\GAL4^Tub.PU

hep^KK116295

short lived, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

hep^UAS.cBa

some die during embryonic stage, with Scer\GAL4^69B

hep^Act.UAS

some die during embryonic stage, with Scer\GAL4^e22c

hep^CA.UAS

some die during embryonic stage | recessive

hep¹

some die during embryonic stage | recessive | maternal effect | recessive

hep¹

some die during embryonic stage | rescuable maternal effect

hep¹

some die during pupal stage

some die during pupal stage | recessive

visible

hep¹

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^GMR.PU

hep^Act.UAS.cUa

visible, with Scer\GAL4^hs.2sev

hep^Act.UAS

visible, with Scer\GAL4^pnr-MD237

hep^UAS.cBa

visible, with Scer\GAL4^ptc-559.1

hep^UAS.cBa

visible, with Scer\GAL4^sev.PU

hep^CA.UAS

visible (with hep¹)

visible (with hep⁶⁹⁹)

hep¹

visible (with hep^r39)

hep¹

visible (with hep^r75)

hep¹

visible | adult stage, with Scer\GAL4^GMR.PF

visible | adult stage, with Scer\GAL4^GMR.PU

hep^CA.UAS

visible | adult stage, with Scer\GAL4^rn-GAL4-5

hep^CA.UAS

visible | dominant

hep^CA

visible | recessive

hep¹

wild-type

Phenotype manifest in

Allele

adult gut, with Scer\GAL4^NP5130

adult gut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

hep^UAS.cBa

adult head

hep^r75

adult head | rescuable maternal effect

hep¹

adult mesothoracic segment | dorsal | rescuable maternal effect

hep¹

adult midgut, with Scer\GAL4^NP5130

hep^UAS.cBa

adult midgut enterocyte, with Scer\GAL4^NP0001

hep^UAS.cBa

adult midgut epithelium, with Scer\GAL4^esg.PU

hep^UAS.cBa

adult midgut epithelium, with Scer\GAL4^NP0001

hep^UAS.cBa

adult thorax

hep¹

adult thorax (with hep¹)

adult thorax (with hep^r39)

hep¹

adult thorax (with hep^r75)

hep¹

adult thorax & macrochaeta, with Scer\GAL4^pnr-MD237

hep^UAS.cBa

adult thorax | dorsal

hep¹

adult thorax | dorsal, with Scer\GAL4^pnr-MD237

hep^UAS.cBa

adult thorax | dorsal | maternal effect

hep¹

amnioserosa

anterior crossvein, with Scer\GAL4^ptc-559.1

anterior crossvein | adult stage, with Scer\GAL4^ptc-559.1

hep^CA.UAS

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

hep^CA.UAS

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc.PU

hep^UAS.cBa

autolysosome | third instar larval stage, with Scer\GAL4^Act5C.PP

hep^Act.UAS

autophagosome | third instar larval stage, with Scer\GAL4^Act5C.PP

hep^Act.UAS

axon & dorsal cluster neuron

hep¹

axon & dorsal cluster neuron, with Scer\GAL4^ato.3.6

hep^CA.UAS

axon | somatic clone

basement membrane | pupal stage

hep^r75

cephalopharyngeal skeleton

hep^r75

cephalopharyngeal skeleton | germline clone

hep^r75

chaeta (with hep¹)

chaeta (with hep^r39)

hep¹

chaeta (with hep^r75)

hep¹

cuticle & abdomen

hep^r75

cuticle & abdomen | germ-line clone

hep^r75

cuticle & thorax

hep^r75

cuticle & thorax | germ-line clone

hep^r75

cuticle | dorsal | rescuable maternal effect (with hep¹)

hep^r75

cuticle | dorsal | rescuable maternal effect (with hep^r75)

hep¹

dorsal appendage

hep¹

dorsal appendage | maternal effect | somatic clone

hep^r75

dorsal mesothoracic disc & cytoskeleton

hep^r75

egg chamber, with Scer\GAL4^GR1

hep^CA.UAS

egg chamber | anterior | somatic clone

hep^r75

embryo | dorsal closure stage

embryo | dorsal closure stage | germline clone

embryo | maternal effect, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

hep^GL00089

embryonic/first instar larval cuticle, with Scer\GAL4^69B

embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS

hep^Act.UAS

embryonic/first instar larval cuticle | dorsal

hep¹

embryonic/first instar larval cuticle | dorsal | rescuable maternal effect

hep¹

embryonic/larval epidermis | third instar larval stage, with Scer\GAL4^pnr-MD237

hep^CA.UAS

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Act5C.PP

hep^Act.UAS

embryonic/larval gut | third instar larval stage, with Scer\GAL4^Act5C.PP

hep^Act.UAS

embryonic dorsal epidermis

embryonic epidermis

embryonic leading edge cell

hep^unspecified

embryonic leading edge cell, with Scer\GAL4^ptc-559.1

embryonic leading edge cell & actin filament

embryonic leading edge cell & filopodium

hep^r75

embryonic leading edge cell | rescuable maternal effect

hep¹

embryonic leading edge cell | rescuable maternal effect (with hep¹)

hep^r75

embryonic leading edge cell | rescuable maternal effect (with hep^r75)

hep¹

embryonic maxillary segment, with Scer\GAL4^arm.PS

hep^Act.UAS

enteroblast, with Scer\GAL4^NP0001

hep^UAS.cBa

eye

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

eye, with Scer\GAL4^hs.2sev

eye, with Scer\GAL4^sev.EP

hep^Act.UAS

eye, with Scer\GAL4^sev.PU

hep^CA.UAS

eye | somatic clone, with Scer\GAL4^GMR.PF

hep^CA.UAS

eye-antennal disc

hep^r75

eye disc, with Scer\GAL4^GMR.PU

eye disc, with Scer\GAL4^hs.2sev

hep^Act.UAS

eye disc, with Scer\GAL4^sev.PU

hep^CA.UAS

eye disc | third instar larval stage, with Scer\GAL4^GMR.PF

hep^CA.UAS

eye disc | third instar larval stage, with Scer\GAL4^sev.PU

hep^CA.UAS

eye disc morphogenetic furrow | third instar larval stage, with Scer\GAL4^GMR.PU

hep^CA.UAS

eye photoreceptor cell

hep^r75

female terminalia (with hep¹)

hep⁶⁹⁹

female terminalia (with hep⁶⁹⁹)

hep¹

follicle cell, with Scer\GAL4^GR1

hep^CA.UAS

follicle cell | somatic clone

hep^r75

genital disc, with Scer\GAL4^Abd-B-LDN

hep^UAS.cBa

genital disc, with Scer\GAL4^ptc-559.1

hep^UAS.cBa

imaginal disc

interommatidial bristle

hep^r75

interommatidial bristle, with Scer\GAL4^GMR.PF

hep^UAS.cGa

intestinal stem cell, with Scer\GAL4^esg.PU

hep^UAS.cBa

intestinal stem cell, with Scer\GAL4^NP0001

hep^UAS.cBa

intestinal stem cell | adult stage, with Scer\GAL4^NP5130

hep^UAS.cBa

Kenyon cell | somatic clone

lamellocyte, with Scer\GAL4^He.PZ

hep^CA.UAS

lamellocyte, with Scer\GAL4^Hml.PG

hep^CA.UAS

lamina

hep^r75

leg

hep¹

leg | pupal stage

hep^r75

macrochaeta | maternal effect

hep¹

maxillary palpus (with hep¹)

hep⁶⁹⁹

maxillary palpus (with hep⁶⁹⁹)

hep¹

melanotic mass, with Scer\GAL4^He.PZ

hep^CA.UAS

melanotic mass, with Scer\GAL4^Hml.PG

hep^CA.UAS

mesothoracic tergum

hep¹

micropyle | maternal effect | somatic clone

hep^r75

midgut | adult stage, with Scer\GAL4^NP5130

hep^UAS.cBa

neuroblast | larval stage, with Scer\GAL4^wor.PA

hep^CA.UAS

neuron

hep^r75

ommatidial precursor cluster, with Scer\GAL4^hs.2sev

hep^Act.UAS

ommatidium, with Scer\GAL4^hs.2sev

hep^UAS.cBa

peripodial epithelium & dorsal mesothoracic disc & prepupa

hep^r75

peripodial stalk & dorsal mesothoracic disc & prepupa

hep^r75

pigment cell

hep^r75

scutellum, with Scer\GAL4^pnr-MD237

hep^UAS.cBa

thorax

hep¹

ventral adult lateral neuron & axon, with Scer\GAL4^P2.4.Pdf

hep^CA.UAS

ventral furrow, with Scer\GAL4^twi.PG

hep^UAS.cBa

ventral midline of embryo | embryonic stage 13, with Scer\GAL4^sim.PS

hep^CA.UAS

ventral midline of embryo | embryonic stage 13 | conditional, with Scer\GAL4^sim.PS

hep^CA.UAS

ventral thoracic disc

hep^r75

wing

wing, with Scer\GAL4^vg.PU

hep^CA.UAS

wing | ectopic, with Scer\GAL4^rn-GAL4-5

hep^CA.UAS

wing | pupal stage

hep^r75

wing | rescuable maternal effect

hep¹

wing disc

wing disc, with Scer\GAL4^ptc-559.1

hep^UAS.cUa

wing disc | prepupal stage

hep^r75

wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

hep^UAS.cBa

wing margin, with Scer\GAL4^vg.PU

hep^CA.UAS

wing vein, with Scer\GAL4^vg.PU

hep^CA.UAS

wing vein L5, with Scer\GAL4^CY2

hep^CA.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\MAP2K7

12 of 15

Yes

Hsap\LOC100996792

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Map2k7

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (9)

Rnor\Map2k7

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (6)

Xtro\map2k7

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (9)

Drer\map2k7

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\mek-1

11 of 15

Yes

Cele\jkk-1

5 of 15

Yes

Cele\sek-5

3 of 15

Cele\sek-4

2 of 15

Cele\F48E3.9

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (10)

Atha\MEK1

3 of 9

Yes

Atha\MKK2

3 of 9

Yes

Atha\MKK3

3 of 9

Yes

Atha\MKK4

3 of 9

Yes

Atha\MKK5

3 of 9

Yes

Atha\MKK6

3 of 9

Yes

Atha\MKK7

3 of 9

Yes

Atha\MKK8

3 of 9

Yes

Atha\MKK9

3 of 9

Yes

Atha\MKK10

3 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\PBS2

2 of 15

Yes

Scer\MKK2

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\wis1

2 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

2 of 10

lic

2 of 10

Mkk4

2 of 10

fray

1 of 10

GckIII

1 of 10

hpo

1 of 10

hppy

1 of 10

mbt

1 of 10

Mekk1

1 of 10

msn

1 of 10

Pak3

1 of 10

Pak

1 of 10

Slik

1 of 10

Stlk

1 of 10

Tao

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

hep^Act.UAS

model of heart disease

CEA

(Karekar et al., 2021)

model of carcinoma

CEA with BacA\p35^UAS.cHa

(Uhlirova and Bohmann, 2006)

hep^UAS.cBa

model of cancer

CEA with aPKC^{UAS.Tag:CAAX(Unk)}

(Bunker et al., 2015)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 7 )

Allele

Disease

Interaction

References

hep^NIG.4353R

exacerbates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Igaki et al., 2006)

ameliorates human immunodeficiency virus infectious disease

modeled by HIV-1\Vpu^UAS.cLa

(Marchal et al., 2012)

hep¹

ameliorates human immunodeficiency virus infectious disease

modeled by HIV-1\nef^UAS.cLa

(Lee et al., 2005)

ameliorates intestinal cancer

modeled by Sox21a⁶

(Zhai et al., 2015)

hep^Act.UAS

ameliorates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

exacerbates colorectal cancer

modeled by Ras85D^V12.UAS

(Bangi et al., 2012)

ameliorates carcinoma

modeled by scrib¹

(Uhlirova et al., 2005)

modeled by Raf^UAS.F179

(Uhlirova et al., 2005)

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Uhlirova and Bohmann, 2006)

hep^UAS.cBa

exacerbates human immunodeficiency virus infectious disease

modeled by HIV-1\nef^UAS.cLa

(Lee et al., 2005)

hep^r75

ameliorates cancer

modeled by scrib¹

(Bunker et al., 2015)

hep^GD1461

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

hep^Act.UAS.cUa

exacerbates neurodegenerative disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Tare et al., 2011)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

modeled by Hsap\APP^2xAPP.SP.UAS

(Sarkar et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MAP2K7; mitogen-activated protein kinase kinase 7

12 of 15

603014

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

hep - Aplip1

anti tag coimmunoprecipitation, anti tag western blot, pull down

(Horiuchi et al., 2007, Taru et al., 2002)

hep - Cka

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation

(La Marca et al., 2019, Chen et al., 2002)

hep - Strip

anti bait coimmunoprecipitation, western blot

(La Marca et al., 2019)

hep - bsk

pull down, anti tag western blot

(Taru et al., 2002)

hep - slpr

enzymatic study, autoradiography

(Sathyanarayana et al., 2003)

hep - wnd

anti tag coimmunoprecipitation, anti tag western blot

(Horiuchi et al., 2007)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hep

suppressible

alph

(Baril et al., 2009)

hep

suppressible

arm

(Zhang et al., 2015, Kaltschmidt et al., 2002)

hep

suppressible

Axn

(Zhang et al., 2015)

hep

suppressible

bsk

(Ren et al., 2017, Zhang et al., 2015, Mathew et al., 2011, Baril et al., 2009, Cha et al., 2005, Geuking et al., 2005)

hep

suppressible

btl

(Srahna et al., 2006)

hep

suppressible

cbt

(Munoz-Descalzo et al., 2005)

hep

enhanceable

chic

(Jasper et al., 2001)

hep

suppressible

chic

(Jasper et al., 2001)

hep

suppressible

chm

(Miotto et al., 2006)

hep

suppressible

Cka

(Chen et al., 2002)

Pvr|hep

suppressible

Diap1

(Mathieu et al., 2007)

hep

suppressible

dsh

(Zhang et al., 2015, Kaltschmidt et al., 2002)

hep

suppressible

ena

(Rudrapatna et al., 2014)

hep

suppressible

Ets21C

(Mundorf et al., 2019)

hep

enhanceable

flw

(Kirchner et al., 2007)

hep

suppressible

foxo

(Wang et al., 2005)

suppressible

(Ren et al., 2017)

enhanceable

(Miotto et al., 2006)

hep

suppressible

Jra

(Miotto et al., 2006, Hou et al., 1997)

hep

suppressible

kay

(Meng and Biteau, 2015, Miotto et al., 2006)

Pvr|hep

suppressible

kay

(Mathieu et al., 2007)

enhanceable

(Sun et al., 2019)

enhanceable

(Rallis et al., 2010)

hep

suppressible

Mkk4

(Geuking et al., 2009)

hep

suppressible

NLaz

(Hull-Thompson et al., 2009)

hep

suppressible

pan

(Zhang et al., 2015)

hep

suppressible

park

(Hwang et al., 2010)

hep

suppressible

PEK

(Wang et al., 2015)

hep

suppressible

puc

(Bosch et al., 2005, Wang et al., 2003, Agnes et al., 1999, Zeitlinger and Bohmann, 1999, Martin-Blanco et al., 1998)

hep

enhanceable

puc

(Baril et al., 2009, Zeitlinger and Bohmann, 1999)

hep

enhanceable

pyd

(Takahashi et al., 1998)

hep

suppressible

Rac1

(Srahna et al., 2006)

hep

suppressible

sgg

(Zhang et al., 2015)

hep

suppressible

Sox21a

(Meng and Biteau, 2015)

hep

suppressible

tsr

(Rudrapatna et al., 2014)

hep

suppressible

(Zhang et al., 2015, Kaltschmidt et al., 2002)

hep

enhanceable

Wnt4

(Sato et al., 2006)

hep

suppressible

Xbp1

(Wang et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

alph

suppressible

hep

(Baril et al., 2009)

Apc2|Apc

suppressible

hep

(Wang et al., 2013)

arm

suppressible

hep

(McEwen et al., 2000)

Axud1

suppressible

hep

(Glavic et al., 2009)

ben

suppressible

hep

(Ma et al., 2014)

enhanceable

hep

(Adachi-Yamada et al., 1999)

enhanceable

hep

(Lee et al., 2003)

chm

enhanceable

hep

(Miotto et al., 2006)

Cka

suppressible

hep

(Chen et al., 2002)

CtBP|egr

suppressible

hep

(Worley et al., 2018)

Dad1

suppressible

hep

(Zhang et al., 2016)

Daxx

enhanceable

hep

(Hwang et al., 2013)

Daxx

suppressible

hep

(Hwang et al., 2013)

suppressible

hep

(Barros and Bossing, 2021)

dpp

enhanceable

hep

(Adachi-Yamada et al., 1999)

drpr

suppressible

hep

(Etchegaray et al., 2012)

dsh

suppressible

hep

(Srahna et al., 2006, Paricio et al., 1999, Boutros et al., 1998)

suppressible

(Lim et al., 2012)

suppressible

(Sun et al., 2019, Geuking et al., 2009, Polaski et al., 2006, Igaki et al., 2002)

suppressible

(Sun et al., 2019)

suppressible

(Ma et al., 2017)

enhanceable

(Wang et al., 2005)

Gadd45

suppressible

hep

(Peretz et al., 2007)

grnd

suppressible

hep

(Andersen et al., 2015)

suppressible

hep

(Müller et al., 2005)

InR

suppressible

hep

(Wang et al., 2005)

suppressible

hep

(Singh et al., 2006)

lace

suppressible

hep

(Adachi-Yamada et al., 1999)

suppressible

(Lee et al., 2006)

enhanceable

(Lee et al., 2006)

suppressible

(Rallis et al., 2010)

Mkk4

enhanceable

hep

(Rallis et al., 2010)

msn

suppressible

hep

(Paricio et al., 1999)

Mtl|Rac1|Rac2

suppressible

hep

(Woolner et al., 2005)

Myc

suppressible

hep

(de la Cova et al., 2004)

enhanceable

(Cha et al., 2005)

suppressible

(Cha et al., 2005)

suppressible

(Maillet et al., 2008)

puc

suppressible

hep

(Wang et al., 2003, Weber et al., 2000, Zeitlinger and Bohmann, 1999)

puc|tkv

suppressible

hep

(Adachi-Yamada et al., 1999)

Pvf1

enhanceable

hep

(Mathieu et al., 2007)

Pvr

suppressible

hep

(Bond and Foley, 2012)

Pvr

enhanceable

hep

(Mathieu et al., 2007, Ishimaru et al., 2004)

Rab30

enhanceable

hep

(Thomas et al., 2009)

Rac1

suppressible

hep

(Stronach and Perrimon, 2002, Fanto et al., 2000)

Raf

suppressible

hep

(Uhlirova et al., 2005)

Raf|scrib

suppressible

hep

(Uhlirova et al., 2005)

Rala

suppressible

hep

(Sawamoto et al., 1999)

Ras85D

enhanceable

hep

(Bangi et al., 2012, Uhlirova and Bohmann, 2006)

Ras85D|shg

suppressible

hep

(Igaki et al., 2006)

Rbf

suppressible

hep

(Milet et al., 2014)

rpr

suppressible

hep

(Kuranaga et al., 2002)

RpS3|yki

suppressible

hep

(Wada et al., 2021)

scrib

suppressible

hep

(Bunker et al., 2015, Wu et al., 2010, Uhlirova et al., 2005)

Slik

suppressible

hep

(Hipfner and Cohen, 2003)

slpr

suppressible

hep

(Baril et al., 2009)

Sox21a

suppressible

hep

(Zhai et al., 2015)

Src42A

enhanceable

hep

(Tateno et al., 2000)

Syx7

suppressible

hep

(Andersen et al., 2015)

Tak1

suppressible

hep

(Xue et al., 2007, Mihaly et al., 2001, Takatsu et al., 2000)

suppressible

hep

(Umehara et al., 2010)

tkv

enhanceable

hep

(Adachi-Yamada et al., 1999)

tkv

suppressible

hep

(Adachi-Yamada et al., 1999)

Traf4

suppressible

hep

(Cha et al., 2003, Kuranaga et al., 2002)

Wnt4

enhanceable

hep

(Sato et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58642

DroID - A comprehensive database of gene and protein interactions.

FBgn0010303

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Pvr Signaling Pathway Core Components -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Imd Signaling Pathway Core Components -: The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
TNFα-Eiger Signaling Pathway Core Components -: The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-41

Cytogenetic map

11D10-11D10

Sequence location

X:13,079,205..13,090,434 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11D10-11D10

Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640^EP1626

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

11D1-11D4

(determined by in situ hybridisation) 11D (determined by in situ hybridisation)

(Peter et al., 2002)

11D-11D

(determined by in situ hybridisation)

(Schäfer et al., 1999.12.2)

11D1-11D4

(determined by in situ hybridisation)

(Schäfer et al., 1999.12.10)

11D-11D

(Noselli, 1994.1.18)

11D1-11D2

(Noselli, 1996.4.28)

11D1-11D2

(determined by in situ hybridisation)

(Glise et al., 1995)

11B12-13F

(Perrimon et al., 1989)

Determined by complementation mapping, aberrations not specified.

(Perrimon et al., 1989)

Experimentally Determined Recombination Data

Location

1-41

(FlyBase, 2016)

1-41.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

58779

9308

9306

6761

6406

y¹ w¹¹¹⁸; P{UAS-hep.CA}4

9307

P{UAS-hep.B}1, w^*/FM6, w^*

58781

y¹ w^*; P{UAS-hep.CA}2/SM1

9305

P{UAS-Hep.Act}1, w^*/FM6, w^*

Kyoto

108771

y¹ w¹¹¹⁸; P{UAS-hep.CA}4

VDRC

v109277

P{KK116295}VIE-260B

v2968

w¹¹¹⁸ P{GD1461}v2968

v47507

w¹¹¹⁸; P{GD1461}v47507

More stocks available...

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (140)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010303

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010303

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32256

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Rallis et al., 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: hep l(1)G0107 l(1)G0208

(Peter et al., 2002)

Source for merge of: hep CG2190

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG4353 and CG2190 merged as CG4353 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Injection of dsRNA targeting hep results in 11.5% embryos showing a dorsal open phenotype.

(Thomas et al., 2009)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

hep is necessary for actin-cable assembly and actin-based cell process formation in leading edge cells during dorsal closure.

(Kaltschmidt et al., 2002)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

hep is essential for the correct morphogenesis of the dorsal appendage and micropyle.

(Suzanne et al., 2001)

hep controls puc expression but not dpp expression in imaginal discs.

(Agnes et al., 1999)

hep and the JNK pathway are required for correct morphogenesis of the imaginal discs.

(Agnes et al., 1999)

Candidate gene for posterior lobe area quantitative trait locus.

(Macdonald and Goldstein, 1999)

Show no or weak ommatidial precursor polarity phenotypes in imaginal tissues.

(Paricio et al., 1999)

The JNK pathway (which includes hep) is required for thorax closure during metamorphosis.

(Zeitlinger and Bohmann, 1999)

hep is required for normal dpp expression in the leading edge during dorsal closure. puc is both a repressor and a target of hep function in the leading edge. The combined and antagonistic functions of hep and puc maintain appropriate levels of puc and dpp activities in migrating epithelia during dorsal closure. These results indicate a leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.

(Glise and Noselli, 1997)

The JNK pathway is conserved between vertebrates and Drosophila and is involved in controlling cell morphogenesis in Drosophila.

(Riesgo-Escovar et al., 1996)

Data suggests that hep functions in a novel MAPK pathway controlling puc expression and morphogenetic activity of the dorsal epidermis.

(Glise et al., 1995)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 80 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32256

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q23977

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q23977

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q23977

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010303

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010303

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32256/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010303

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

hep_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010303

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010303

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4353

Flygut - An atlas of the Drosophila adult midgut

FBgn0010303

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

92142

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32256

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4353

MARRVEL_MODEL - MARRVEL (model organism gene)

32256

modMine - A data warehouse for the modENCODE project

FBgn0010303

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q23977

Linkouts

BioGRID - A database of protein and genetic interactions.

58642

DroID - A comprehensive database of gene and protein interactions.

FBgn0010303

DRSC - Results frm RNAi screens

FBgn0010303

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010303

FlyMine - An integrated database for Drosophila genomics

FBgn0010303

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (35)

Reported As

Symbol Synonym

CG2190

(Claridge-Chang et al., 2001)

CG4353

(Butzlaff et al., 2015, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Rogers et al., 2003, Morrison et al., 2000)

D-MKK7

(Ryabinina et al., 2006)

DHEP/MKK7

(Chen et al., 2002)

DJNKK

(Miotto et al., 2006)

DMKK7

(Ip and Davis, 1998)

HEP

(Udomsinprasert et al., 2004, Weitzman, 2000, Sluss and Davis, 1997)

HEP/MKK7

(Bjorklund et al., 2006, Morrison et al., 2000)

Hep

(Gan et al., 2021, Herrera and Bach, 2021, Kramer et al., 2021, Chen et al., 2020, La Marca and Richardson, 2020, Meng et al., 2020, Morris et al., 2020, Rodriguez-Fernandez et al., 2020, Zhou and Boutros, 2020, Cai et al., 2019, Mirzoyan et al., 2019, Toshniwal et al., 2019, Baena-Lopez et al., 2018, Cong et al., 2018, Wang et al., 2018, Yanku et al., 2018, Houtz et al., 2017, Liao et al., 2017, Liu and Jin, 2017, Ma et al., 2017, Ren et al., 2017, Schimizzi et al., 2016, Voelzmann et al., 2016, Bornstein et al., 2015, Meng and Biteau, 2015, Ríos-Barrera et al., 2015, Wang et al., 2015, Wang et al., 2015, Wu et al., 2015, Zhang et al., 2015, Huang et al., 2014, Ma et al., 2014, Schulman et al., 2014, Wang et al., 2014, Karpac et al., 2013, Pechkovsky et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Tang et al., 2013, Vaque et al., 2013, Wang et al., 2013, Zhang et al., 2013, Bangi et al., 2012, Bier and Guichard, 2012, Gistelinck et al., 2012, Kelsey et al., 2012, Lu et al., 2012, Ma et al., 2012, Bangi et al., 2011, Biteau et al., 2011, Jiang et al., 2011, Biteau et al., 2010, Oliva and Sierralta, 2010, Apidianakis et al., 2009, Geuking et al., 2009, Glavic et al., 2009, Igaki et al., 2009, Jiang et al., 2009, Liu et al., 2009, Ohayon et al., 2009, Rodahl et al., 2009, Thomas et al., 2009, Wu et al., 2009, Wu et al., 2009, Llense and Martín-Blanco, 2008, Maillet et al., 2008, Lee et al., 2006, Ryabinina et al., 2006, Sano et al., 2005, Cha et al., 2003)

Hep/Mkk7

(Geuking et al., 2009)

JNKK

(Mondal et al., 2018, Vaqué et al., 2013, Bangi et al., 2011, Jiang et al., 2011, Gettings et al., 2010, Glavic et al., 2009, Liu et al., 2009, Rodahl et al., 2009, Llense and Martín-Blanco, 2008, Homsy et al., 2006, Delaney et al., 2005, Stronach and Perrimon, 1999)

Jnkk

(Stuelten et al., 2018)

MAP2K7

(Vaqué et al., 2013)

MAPKK

(Yadav et al., 2016, Horiuchi et al., 2007)

MKK7

(Galenza and Foley, 2019, Vandenabeele and Bertrand, 2012, Horiuchi et al., 2007, Sathyanarayana et al., 2003)

Mkk7

(Geuking et al., 2009)

dJNKK

(Bidla et al., 2007)

dMKK7

(Bond and Foley, 2012, Bond and Foley, 2009)

hem

(Chanut-Delalande et al., 2006)

hep

(Evans et al., 2022, Gera et al., 2022, Havula et al., 2022, Bahuguna et al., 2021, Buhlman et al., 2021, Fabian et al., 2021, Girard et al., 2021, Harnish et al., 2021, Hsu et al., 2021, Järvelä-Stölting et al., 2021, Karekar et al., 2021, Karkali and Martin-Blanco, 2021, Klemm et al., 2021, Liang et al., 2021, Mesquita et al., 2021, Mishra et al., 2021, Mok and Choi, 2021, Sheng et al., 2021, Wada et al., 2021, Yoo et al., 2021, Yu et al., 2021, Ai et al., 2020, Banreti and Meier, 2020, Estacio-Gómez et al., 2020, FlyBase Genome Annotators, 2020, Gogia et al., 2020, Harris et al., 2020, Irwin et al., 2020, Jeon et al., 2020, Krautz et al., 2020, Port et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Wang et al., 2020, Zhang et al., 2020, Aryal and Lee, 2019, Banerjee et al., 2019, Chai et al., 2019, Chang et al., 2019, FlyBase Genome Annotators, 2019-, Hu and Jasper, 2019, Katsube et al., 2019, Lee et al., 2019, Luo et al., 2019, Ma et al., 2019, Mishra-Gorur et al., 2019, Mundorf et al., 2019, Sanchez et al., 2019, Sun et al., 2019, Tang et al., 2019, Varga et al., 2019, Wang et al., 2019, Wu et al., 2019, Xu et al., 2019, Zhang et al., 2019, Ahmed-de-Prado et al., 2018, Bushnell et al., 2018, Chi et al., 2018, Donohoe et al., 2018, Jeong et al., 2018, Koon et al., 2018, Li et al., 2018, Liu et al., 2018, Mecklenburg et al., 2018, Mondal et al., 2018, Pinal et al., 2018, Richardson and Portela, 2018, Sarkar et al., 2018, Tsai et al., 2018, Yang et al., 2018, Branco et al., 2017, Early et al., 2017, Jordán-Álvarez et al., 2017, Lee et al., 2017, Ma et al., 2017, Martín et al., 2017, Muzzopappa et al., 2017, Tang et al., 2017, Aggarwal et al., 2016, Bielmeier et al., 2016, Boone et al., 2016, Diaz-Garcia et al., 2016, Fogarty et al., 2016, Harris et al., 2016, Ma et al., 2016, Willsey et al., 2016, Zhang et al., 2016, Butzlaff et al., 2015, Chen et al., 2015, Doggett et al., 2015, Katsuyama et al., 2015, Legent et al., 2015, Liu et al., 2015, Omelyanchuk et al., 2015, Santabárbara-Ruiz et al., 2015, Siudeja et al., 2015, Vlisidou and Wood, 2015, Wang et al., 2015, Zhai et al., 2015, Ashwal-Fluss et al., 2014, Chuang et al., 2014, Fernández et al., 2014, Kuang et al., 2014, Merlo et al., 2014, Milet et al., 2014, Pereira et al., 2014, Rudrapatna et al., 2014, Soares et al., 2014, Sopko et al., 2014, Wong et al., 2014, Hwang et al., 2013, Külshammer and Uhlirova, 2013, Ma et al., 2013, Ma et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Sun and Irvine, 2013, Vaqué et al., 2013, Webber et al., 2013, Yang et al., 2013, Bangi et al., 2012, Bond and Foley, 2012, Brock et al., 2012, Etchegaray et al., 2012, Gonda et al., 2012, Hainaut et al., 2012, Hong et al., 2012, Lim et al., 2012, Marchal et al., 2012, Yoshioka et al., 2012, Belacortu et al., 2011, Chung et al., 2011, Hong et al., 2011, Jiang et al., 2011, Jungreis et al., 2011, Mathew et al., 2011, Repiso et al., 2011, Sekine et al., 2011, Tare et al., 2011, Zhao et al., 2011, Bergantiños et al., 2010, Blanco et al., 2010, Cobreros-Reguera et al., 2010, Djiane and Mlodzik, 2010, Gettings et al., 2010, Hwang et al., 2010, Kim et al., 2010, Kwon et al., 2010, Lennox and Stronach, 2010, Neisch et al., 2010, Popodi et al., 2010-, Portela et al., 2010, Rallis et al., 2010, Rousset et al., 2010, Umehara et al., 2010, Venken et al., 2010, Wu et al., 2010, Zhang et al., 2010, Baril et al., 2009, Buchon et al., 2009, Cruz et al., 2009, Hill-Burns and Clark, 2009, Hull-Thompson et al., 2009, Karpac et al., 2009, Lee et al., 2009, Pérez-Garijo et al., 2009, Tokusumi et al., 2009, Tuxworth et al., 2009, Ayaz et al., 2008, Biteau et al., 2008, Davis et al., 2008, Domingues and Ryoo, 2008, Fiehler and Wolff, 2008, Jones et al., 2008, Maillet et al., 2008, Pastor-Pareja et al., 2008, Titen and Golic, 2008, Tresch and Markowetz, 2008, Yoshioka et al., 2008, Bidla et al., 2007, Fernández et al., 2007, Horiuchi et al., 2007, Hueber et al., 2007, Kirchner et al., 2007, Lee et al., 2007, Lin et al., 2007, Luo et al., 2007, Mathieu et al., 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Peretz et al., 2007, Srivastava et al., 2007, Stronach et al., 2007, Umemori et al., 2007, Valanne et al., 2007, Walther and Pichaud, 2007, Xue et al., 2007, Cerrato et al., 2006, Guichard et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Jordan et al., 2006, Lee et al., 2006, Mulinari et al., 2006, Murray et al., 2006, Park et al., 2006, Polaski et al., 2006, Sato et al., 2006, Singh et al., 2006, Srahna et al., 2006, Uhlirova and Bohmann, 2006, Etter et al., 2005, Gesellchen et al., 2005, Lee et al., 2005, Uhlirova et al., 2005, Pastor-Pareja et al., 2004, Ryoo et al., 2004)

hep/JNKK

(Yin et al., 2013)

(Noselli et al., 1994, Noselli et al., 1993)

hrp

(Wu et al., 2010)

l(1)7P1

l(1)G0107

(Schäfer et al., 1999.12.10)

l(1)G0208

(Schäfer et al., 1999.12.2)

Name Synonyms

Hemipterus

(Ahmed-de-Prado and Baonza, 2018, Katsuyama and Paro, 2011)

Hempiterous

(Titen and Golic, 2008)

JNK kinase

(Rodahl et al., 2009, Eissenberg, 2006)

JNK-Kinase

(Glavic et al., 2009)

JNK-kinase

(Etter et al., 2005)

Mitogen-activated protein kinase kinase 7

(Lee et al., 2010)

hemipterous

(Tatapudy et al., 2021, Brace and DiAntonio, 2017, Branco et al., 2017, Bielmeier et al., 2016, Hannan et al., 2016, Santabárbara-Ruiz et al., 2015, Zhai et al., 2015, Kuang et al., 2014, Pereira et al., 2014, Soares et al., 2014, Herrera et al., 2013, Karpac et al., 2013, Etchegaray et al., 2012, Gomez et al., 2012, Hainaut et al., 2012, Lu et al., 2012, Pool et al., 2012, Kraut, 2011, Lee et al., 2011, Repiso et al., 2011, Bergantiños et al., 2010, Gettings et al., 2010, Hwang et al., 2010, Lennox and Stronach, 2010, Portela et al., 2010, Rhiner et al., 2010, Buchon et al., 2009, Corl et al., 2009, Cruz et al., 2009, Hill-Burns and Clark, 2009, Jiang et al., 2009, Bakal et al., 2008, Fiehler and Wolff, 2008, Wu et al., 2008, Yoshioka et al., 2008, Bidla et al., 2007, Fernández et al., 2007, Lee et al., 2007, Walther and Pichaud, 2007, Bovolenta et al., 2006, Cerrato et al., 2006, Delaney et al., 2006, Hashimoto and Yamaguchi, 2006, Homsy et al., 2006, Sato et al., 2006, Etter et al., 2005, Lee et al., 2005)

hemipterus

(Huang et al., 2014)

Secondary FlyBase IDs

FBgn0013490
FBgn0029076
FBgn0030446
FBgn0040188

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (551)

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