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General Information
Symbol
Dmel\hep
Species
D. melanogaster
Name
hemipterous
Annotation Symbol
CG4353
Feature Type
FlyBase ID
FBgn0010303
Gene Model Status
Stock Availability
Gene Snapshot
hemipterous (hep) encodes a serine/threonine protein kinase involved in the Jun-N-terminal kinase pathway by phosphorylating the product of bsk. [Date last reviewed: 2019-03-07]
Also Known As
JNKK, MKK7, hp, MAPKK, dMKK7
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:13,079,205..13,090,434 [-]
Recombination map
1-41
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (Q23977)
Summaries
Gene Group (FlyBase)
STE7 KINASES (MAPK KINASES) -
MAPK kinases are serine/threonine kinases that phosphorylate MAP kinases in MAPK signalling cascades. They belong to the STE7 subfamily of kinases. MAPK kinases are activated by MAPK kinase kinases. (Adapted from FBrf0225276).
Pathway (FlyBase)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis.
(UniProt, Q23977)
Summary (Interactive Fly)
a serine/threonine protein kinase (MapKK/JunKK) involved in dorsal closure - involved in the Jun-N-terminal kinase pathway by phosphorylating Basket - required for the correct differentiation of epithelia
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\hep or the JBrowse view of Dmel\hep for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073747
4893
1178
FBtr0073748
2738
492
FBtr0330396
5344
1162
FBtr0330397
5689
492
FBtr0340303
5344
1153
Additional Transcript Data and Comments
Reported size (kB)
6.0 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073578
125.1
1178
10.05
FBpp0073579
53.1
492
9.19
FBpp0303422
123.2
1162
9.98
FBpp0303423
53.1
492
9.19
FBpp0309264
122.3
1153
9.98
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

492 aa isoforms: hep-PC, hep-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification
MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases. Weakly autophosphorylated.
(UniProt, Q23977)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hep using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (46 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Cka; FB:FBgn0044323
inferred from direct assay
inferred from physical interaction with UniProtKB:Q9W0K0
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441
(assigned by InterPro )
inferred from sequence or structural similarity
traceable author statement
Biological Process (38 terms)
Terms Based on Experimental Evidence (35 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rab30; FB:FBgn0031882
inferred from genetic interaction with FLYBASE:slpr; FB:FBgn0030018
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Mkk4; FB:FBgn0024326
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
hep transcripts are detected throughout development on northern blots. In situ hybridization shows that they are homogeneously distributed throughout the embryo.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
hep protein is detected in mushroom body axons but is less prominent in mushroom body cell bodies. Additional signal is found throughout the adult brain including the antennal lobe.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\hep in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of hep
Transgenic constructs containing regulatory region of hep
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
adult thorax & macrochaeta, with Scer\GAL4pnr-MD237
axon & dorsal cluster neuron
axon & dorsal cluster neuron, with Scer\GAL4ato.3.6
cuticle & abdomen
cuticle & abdomen | germ-line clone
cuticle & thorax
cuticle & thorax | germ-line clone
dorsal mesothoracic disc & cytoskeleton
embryonic leading edge cell & actin filament
embryonic leading edge cell & filopodium
peripodial epithelium & dorsal mesothoracic disc & prepupa
peripodial stalk & dorsal mesothoracic disc & prepupa
ventral adult lateral neuron & axon, with Scer\GAL4P2.4.Pdf
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
7 of 13
Yes
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
9 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (7)
11 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
9 of 15
Yes
Yes
6 of 15
No
Yes
4 of 15
No
No
4 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (10)
3 of 9
Yes
No
3 of 9
Yes
Yes
3 of 9
Yes
No
3 of 9
Yes
No
3 of 9
Yes
No
3 of 9
Yes
No
3 of 9
Yes
No
3 of 9
Yes
No
2 of 9
No
No
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
4 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
3 of 12
Yes
No
2 of 12
No
No
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919034Z )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502RG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02IZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06G9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0A9H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (15)
3 of 10
3 of 10
3 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    suppressible
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
    PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-41
    Cytogenetic map
    Sequence location
    X:13,079,205..13,090,434 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    11D10-11D10
    Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640EP1626
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    11D1-11D4
    (determined by in situ hybridisation) 11D (determined by in situ hybridisation)
    11D-11D
    (determined by in situ hybridisation)
    11D1-11D4
    (determined by in situ hybridisation)
    11D1-11D2
    (determined by in situ hybridisation)
    Determined by complementation mapping, aberrations not specified.
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (20)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (140)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: hep l(1)G0107 l(1)G0208
    Source for merge of: hep CG2190
    Additional comments
    Annotations CG4353 and CG2190 merged as CG4353 in release 3 of the genome annotation.
    Other Comments
    Injection of dsRNA targeting hep results in 11.5% embryos showing a dorsal open phenotype.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
    hep is necessary for actin-cable assembly and actin-based cell process formation in leading edge cells during dorsal closure.
    Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
    hep is essential for the correct morphogenesis of the dorsal appendage and micropyle.
    hep controls puc expression but not dpp expression in imaginal discs.
    hep and the JNK pathway are required for correct morphogenesis of the imaginal discs.
    Candidate gene for posterior lobe area quantitative trait locus.
    Show no or weak ommatidial precursor polarity phenotypes in imaginal tissues.
    The JNK pathway (which includes hep) is required for thorax closure during metamorphosis.
    hep is required for normal dpp expression in the leading edge during dorsal closure. puc is both a repressor and a target of hep function in the leading edge. The combined and antagonistic functions of hep and puc maintain appropriate levels of puc and dpp activities in migrating epithelia during dorsal closure. These results indicate a leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.
    The JNK pathway is conserved between vertebrates and Drosophila and is involved in controlling cell morphogenesis in Drosophila.
    Data suggests that hep functions in a novel MAPK pathway controlling puc expression and morphogenetic activity of the dorsal epidermis.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 80 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (35)
    Reported As
    Symbol Synonym
    hep
    (Chai et al., 2019, Chang et al., 2019, Luo et al., 2019, Ma et al., 2019, Mundorf et al., 2019, Sun et al., 2019, Varga et al., 2019, Wang et al., 2019, Xu et al., 2019, Zhang et al., 2019, Ahmed-de-Prado et al., 2018, Bushnell et al., 2018, Chi et al., 2018, Donohoe et al., 2018, Jeong et al., 2018, Koon et al., 2018, Liu et al., 2018, Mecklenburg et al., 2018, Mondal et al., 2018, Pinal et al., 2018, Richardson and Portela, 2018, Sarkar et al., 2018, Tsai et al., 2018, Yang et al., 2018, Branco et al., 2017, Early et al., 2017, Jordán-Álvarez et al., 2017, Lee et al., 2017, Ma et al., 2017, Martín et al., 2017, Muzzopappa et al., 2017, Aggarwal et al., 2016, Bielmeier et al., 2016, Boone et al., 2016, Diaz-Garcia et al., 2016, Fogarty et al., 2016, Harris et al., 2016, Ma et al., 2016, Willsey et al., 2016, Zhang et al., 2016, Butzlaff et al., 2015, Chen et al., 2015, Doggett et al., 2015, Katsuyama et al., 2015, Legent et al., 2015, Omelyanchuk et al., 2015, Santabárbara-Ruiz et al., 2015, Siudeja et al., 2015, Vlisidou and Wood, 2015, Wang et al., 2015, Zhai et al., 2015, Ashwal-Fluss et al., 2014, Chuang et al., 2014, Fernández et al., 2014, Kuang et al., 2014, Merlo et al., 2014, Milet et al., 2014, Pereira et al., 2014, Rudrapatna et al., 2014, Soares et al., 2014, Sopko et al., 2014, Wong et al., 2014, Hwang et al., 2013, Külshammer and Uhlirova, 2013, Ma et al., 2013, Ma et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Vaqué et al., 2013, Webber et al., 2013, Yang et al., 2013, Bangi et al., 2012, Bond and Foley, 2012, Brock et al., 2012, Etchegaray et al., 2012, Gonda et al., 2012, Hainaut et al., 2012, Hong et al., 2012, Lim et al., 2012, Marchal et al., 2012, Yoshioka et al., 2012, Belacortu et al., 2011, Chung et al., 2011, Hong et al., 2011, Jiang et al., 2011, Jungreis et al., 2011, Mathew et al., 2011, Repiso et al., 2011, Sekine et al., 2011, Tare et al., 2011, Zhao et al., 2011, Bergantiños et al., 2010, Blanco et al., 2010, Cobreros-Reguera et al., 2010, Djiane and Mlodzik, 2010, Gettings et al., 2010, Hwang et al., 2010, Kim et al., 2010, Kwon et al., 2010, Lennox and Stronach, 2010, Neisch et al., 2010, Popodi et al., 2010-, Portela et al., 2010, Rallis et al., 2010, Rousset et al., 2010, Umehara et al., 2010, Venken et al., 2010, Wu et al., 2010, Zhang et al., 2010, Baril et al., 2009, Buchon et al., 2009, Cruz et al., 2009, Hill-Burns and Clark, 2009, Hull-Thompson et al., 2009, Karpac et al., 2009, Lee et al., 2009, Pérez-Garijo et al., 2009, Tokusumi et al., 2009, Tuxworth et al., 2009, Ayaz et al., 2008, Biteau et al., 2008, Davis et al., 2008, Domingues and Ryoo, 2008, Fiehler and Wolff, 2008, Jones et al., 2008, Maillet et al., 2008, Pastor-Pareja et al., 2008, Titen and Golic, 2008, Tresch and Markowetz, 2008, Yoshioka et al., 2008, Bidla et al., 2007, Fernández et al., 2007, Horiuchi et al., 2007, Hueber et al., 2007, Kirchner et al., 2007, Lee et al., 2007, Lin et al., 2007, Luo et al., 2007, Mathieu et al., 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Peretz et al., 2007, Srivastava et al., 2007, Stronach et al., 2007, Umemori et al., 2007, Valanne et al., 2007, Walther and Pichaud, 2007, Xue et al., 2007, Cerrato et al., 2006, Guichard et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Jordan et al., 2006, Lee et al., 2006, Mulinari et al., 2006, Murray et al., 2006, Park et al., 2006, Polaski et al., 2006, Sato et al., 2006, Singh et al., 2006, Srahna et al., 2006, Uhlirova and Bohmann, 2006, Etter et al., 2005, Gesellchen et al., 2005, Lee et al., 2005, Uhlirova et al., 2005, Pastor-Pareja et al., 2004, Ryoo et al., 2004)
    l(1)7P1
    Name Synonyms
    JNK-kinase
    Mitogen-activated protein kinase kinase 7
    hemipterus
    Secondary FlyBase IDs
    • FBgn0013490
    • FBgn0029076
    • FBgn0030446
    • FBgn0040188
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (474)