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Gene Dmel\CycD

General Information
Symbol	Dmel\CycD	Species	D. melanogaster
Name	Cyclin D	Annotation symbol	CG9096
Feature type	protein_coding_gene	FlyBase ID	FBgn0010315
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	cyclinD, Cdi3, dCycD
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13F18-14A1	Sequence location	X:15,800,855..15,803,709 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclin D is referred to in FlyBase by the symbol Dmel\CycD (CG9096, FBgn0010315). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; cyclin-dependent protein serine/threonine kinase regulator activity. There is experimental evidence that it is involved in the biological process: positive regulation of cell growth; cell proliferation; cellular process; cell growth; JAK-STAT cascade; mitochondrion organization. 15 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval midgut primordium; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Cyclin A/B/D/E; Cyclin D; Cyclin, C-terminal domain; Cyclin, N-terminal; Cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627295_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CycD. Gene sequence location is X:15800855..15803709.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13F18-14A1   Limits computationally determined from genome sequence between P{EP}Gβ13FEP1071 and P{EP}EP1458&P{EP}EP1522
Experimentally Determined Cytological Location
Cytogenetic map Notes References 13F-13F     (Jacobs, 2000.4.25)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CycD for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CycD-RD FBtr0300391  NM_078631   2145   477 CycD-RE FBtr0300392  NM_167472   2256   477 CycD-RF FBtr0300393  NM_167473   2453   477
Additional Transcript Data & Comments
Reported size (kB)	2.3, 2.1 (northern blot) (Finley et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CycD-PD   FBpp0289620   53.9   477   6.36     NP_523355   AAN09374 CycD-PE   FBpp0289621   53.9   477   6.36     NP_727912   AAN09375 CycD-PF   FBpp0289622   53.9   477   6.36     NP_727913   AAF48537
Additional Polypeptide Data & Comments
Reported size (kDa)	452 (aa) (Finley et al., 1996)
Comments	A consensus seuquence for D cyclins was derived from a comparison of the CycD sequence with 11 vertebrate D cyclins. CycD protein is functional as shown by its ability to complement a yeast cyclin mutant. (Finley et al., 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, C-terminal domain (IPR004367) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763) Cyclin D (IPR015451) Cyclin A/B/D/E (IPR014400)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202722   AA246773   AA390772   AA539873   AA816591   AA817473   AA950528   AA951354   AA951558   AA951559   AA951826   AE014298 AAF48537   AE014298 AAN09374   AE014298 AAN09375   AF260583 AAG13285   AI455310   AI512274   AY069509 AAL39654   BI163573   BI166957   BI169422   BI170830   BI173222   BI212941   BI213516   BI216507   BI229553   BI229783   BI234243   BI240751   BI243330   BI356814   BI357005   BI357642   BI361720   BI367643   BI371951   BI372723   BI372790   BI375489   BI481822   BI487127   BI578070   BI578533   BI578650   CO184628   CO185796   CO192608   CO196049   CO270696   CO270799   CO283437   CO286240   CO289670   CO291167   CO312016   CO335438   CO336628   EC056725   EC070255   EC082729   EC084970   EC207428   EC208039   EC208310   EC231840   EC240087   EC240536   EC267694   GH748137   GH748144   GH749118   GH749297   GH756960   GH757509   GH757715   GH759051   GH770176   GH774404   GH774763   GH775632   GH775681   GH776148   GH785772   GH794000   GH795310   GH795847   GH797548   GH797689   GH803903   GH805348   GH808060   GH809262   GH809870   GH810031   GH811113   GH817353   GH817399   GH817755   GH818970   GH820620   GH820877   GH824010   GH825333   GH825628   GH827270   GH827481   GH827702   GH829507   GH829914   GH833347   GH838940   GH838994   GH839628   GH839848   GH841686   GH843581   GH844563   GH845158   GH845831   GH847172   GH849389   GH850452   GH853284   GH854135   GH856389   GH856691   GH859079   GH859497   GH860942   GH861842   GH864987   GH865834   GH866566   GH867104   GH867128   GH868843   GH869019   GH870334   GH871719   GH872754   GH872978   GH874406   GH875962   GH879094   GH881631   GH884010   GH887868   GH888570   GH889692   GH890036   GH890376   GH890833   GH892502   GH900118   GH901424   GH902010   GH904655   GH904661   GH906163   GH907018   GH909500   GH910017   GH910063   GH911768   GH913666   GH921601   GH922166   GH922516   GH922599   GH924543   GH927799   GH929049   GH930886   GH934861   GH937460   GH937557   GH938058   GH940786   GH942312   U41808 AAC47016
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KUZ5 Q24158 Q9GTQ8 Q9VXM1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | intense & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Finley et al., 1996) embryonic stage & larval stage     (Finley et al., 1996) third instar larval stage   eye-antennal disc   (Finley et al., 1996) imaginal disc   (Finley et al., 1996) morphogenetic furrow | anterior   (Finley et al., 1996) adult stage | female     (Finley et al., 1996) adult stage | male     (Finley et al., 1996)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    101.65 Larval Midgut    64.9 Larval Hindgut    84 Larval Malpighian Tubules    69.2 Larval Fat Body    51.4 Larval Salivary Gland    193.3 Larval Trachea    117.025 Larval Carcass    83.5 Adult Head    30 Adult Eye    22.85 Adult Brain    19.5 Adult Thoracic-Abdominal Ganglion    21.5 Adult Crop    55.8 Adult Midgut    41.1 Adult Hindgut    42.5 Adult Malpighian Tubules    56 Adult Fat Body    61.2 Adult Salivary Gland    75.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    74.5 Adult InseminatedFemale Spermatheca    78.8 Adult Ovary    384.1 Adult Testis    16.4 Adult Male Accessory Gland    98.2 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    30   NA  Eye    22.85   NA  Brain    19.5   101.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    21.5   NA  Crop    55.8   64.9  Midgut    41.1   84  Hindgut    42.5   69.2  Malpighian Tubules    56   51.4  Fat Body    61.2   193.3  Salivary Gland    75.6   NA  Heart    45.925   117.025  Trachea    NA   NA  VirginFemale Spermatheca    74.5   NA  InseminatedFemale Spermatheca    78.8   NA  Ovary    384.1   NA  Testis    16.4   NA  Male Accessory Gland    98.2   83.5  Carcass    50.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    63 ovary, mated 4-day female    65 testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female  (63) ovary, mated 4-day female  (65) testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    63 ovary, mated 4-day female    65 testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    63 ovary, mated 4-day female    65 testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    63 ovary, mated 4-day female    65 testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female  (63) ovary, mated 4-day female  (65) testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    63 ovary, mated 4-day female    65 testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    8 carcass, 1-day adult    3 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    63 ovary, mated 4-day female    65 testis, mated 4-day male    1 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    55 embryo 04-06hr    37 embryo 06-08hr    38 embryo 08-10hr    49 embryo 10-12hr    35 embryo 12-14hr    30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day    41 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (79) embryo 02-04hr  (55) embryo 04-06hr  (37) embryo 06-08hr  (38) embryo 08-10hr  (49) embryo 10-12hr  (35) embryo 12-14hr  (30) embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr  (27) embryo 22-24hr  (28) larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day  (41) adult female 30day  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    55 embryo 04-06hr    37 embryo 06-08hr    38 embryo 08-10hr    49 embryo 10-12hr    35 embryo 12-14hr    30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day    41 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    55 embryo 04-06hr    37 embryo 06-08hr    38 embryo 08-10hr    49 embryo 10-12hr    35 embryo 12-14hr    30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day    41 adult female 30day    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    55 embryo 04-06hr    37 embryo 06-08hr    38 embryo 08-10hr    49 embryo 10-12hr    35 embryo 12-14hr    30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day    41 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (79) embryo 02-04hr  (55) embryo 04-06hr  (37) embryo 06-08hr  (38) embryo 08-10hr  (49) embryo 10-12hr  (35) embryo 12-14hr  30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr  27 embryo 22-24hr  28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day  (41) adult female 30day  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    55 embryo 04-06hr    37 embryo 06-08hr    38 embryo 08-10hr    49 embryo 10-12hr    35 embryo 12-14hr    30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day    41 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    55 embryo 04-06hr    37 embryo 06-08hr    38 embryo 08-10hr    49 embryo 10-12hr    35 embryo 12-14hr    30 embryo 14-16hr    24 embryo 16-18hr    21 embryo 18-20hr    9 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    14 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    3 adult male 30day    4 adult female 01day    18 adult female 05day    41 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1    39 embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1  (39) embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1    39 embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1    39 embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1    39 embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1  (39) embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1    39 embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    15 embryonic 1182-4H    15 embryonic GM2    17 embryonic Kc167    24 embryonic S1    39 embryonic S3    12 leg disc CME L1    15 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    12 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    24 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    6 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD22957 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010315 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9096-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CycD1 CycD2 CycDCB02618 viable, with Scer\GAL4pnr-MD237 CycDGD14114 Sterility Allele sterile | recessive CycD1 CycD2 Other Phenotypes Allele decreased cell number CycD1 CycD2 decreased cell size, with Scer\GAL4da.G32 CycDScer\UAS.cMa increased cell number, with Scer\GAL4da.G32 CycDScer\UAS.cMa increased cell size CycD1 CycD2 large body, with Scer\GAL4da.G32 CycDScer\UAS.cMa size defective CycD1 small body CycD1 CycD2 small body | somatic clone CycD1 CycD2 wild-type, with Scer\GAL4Act5C.PP CycDScer\UAS.cDa Phenotype manifest in Allele embryonic/larval midgut primordium CycD1 CycD2 wing CycD1 CycD2 wing, with Scer\GAL4da.G32 CycDScer\UAS.cMa wing | somatic clone CycD1 CycD2
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CycD Class Mutagen Stocks Known lesion CycDNP0748 1 -- CycD1 Delta2-3 0 Yes CycD2 Delta2-3 0 Yes CycDCB02618 P-element activity 0 Yes CycDGG01777 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CycD Class Mutagen Stocks Known lesion CycDGD14114 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CycDHMS00059 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycDJF02799 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycDKK108447 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycDcDa in vitro construct 0 Yes CycDcXa in vitro construct 0 Yes CycDGMR.PE in vitro construct - regulatory fusion 0 Yes CycDMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycDScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes CycDScer\UAS.cMa in vitro construct - regulatory fusion 0 --
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14114} NA P{KK108447} NA P{TRiP.HMS00059} NA P{TRiP.JF02799} NA P{UAS-CycD.D} NA P{UAS-CycD.M} NA characterization construct P{GMR-CycD.E} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}CycDNP0748 No miscellaneous insertions P{?SUPor-P}CycD1 NA P{PTT-GB}CycDCB02618 NA P{SUPor-P}KG04817 NA insertion of mobile activating element P{Mae-UAS.6.11}CycDGG01777 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein serine/threonine kinase regulator activity inferred from direct assay (Finley et al., 1996) protein binding inferred from physical interaction with Cdk4 (Meyer et al., 2000)
Biological Process
CV term Evidence References
cell growth inferred from mutant phenotype (Frei et al., 2005) cell proliferation inferred from genetic interaction with Cdk4 (Datar et al., 2000) cellular process inferred from mutant phenotype (Boutros et al., 2004) JAK-STAT cascade inferred from genetic interaction with os, Cdk4 (Chen et al., 2003) mitochondrion organization inferred from mutant phenotype (Frei et al., 2005) positive regulation of cell growth inferred from mutant phenotype (Emmerich et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein serine/threonine kinase regulator activity inferred from sequence or structural similarity with UniProtKB:Q04827 (FlyBase, 1992-) protein kinase binding inferred from electronic annotation with InterPro:IPR014400 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of cyclin-dependent protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR014400 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR004367 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CycD - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CycD - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CycD - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CycD - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CycD allele Gene References CycD1 cdc2c (Emmerich et al., 2004) CycE (Emmerich et al., 2004) dap (Emmerich et al., 2004) CycD2 cdc2c (Emmerich et al., 2004) CycE (Emmerich et al., 2004) dap (Emmerich et al., 2004) CycDScer\UAS.cDa Cdk4 (Datar et al., 2000, Chen et al., 2003) Rbf (Datar et al., 2000) Tsc1 (Tapon et al., 2001) CycDScer\UAS.cMa Cdk4 (Datar et al., 2000, Hipfner et al., 2002) Rbf (Datar et al., 2000) unspecified gig (Tapon et al., 2001) os (Chen et al., 2003) ptc (Duman-Scheel et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58898 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010315 DroID - A comprehensive database of gene and protein interactions. • FBgn0010315 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32551 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24158
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZKK64 Dipteran inclusive ortholog search EOG6K9BMN Insect inclusive ortholog search EOG6F7MFB Arthropod inclusive ortholog search EOG68CZ9P Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6ZKK64)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CycD     Drosophila simulans   Dsim\GD15773 Y   Drosophila sechellia   Dsec\GM22512 Y   Drosophila erecta   Dere\GG19360 Y   Drosophila yakuba   Dyak\GE16008 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25615     Drosophila pseudoobscura pseudoobscura   Dpse\GA25616     Drosophila persimilis   Dper\GL20678 Y   Drosophila willistoni   Dwil\GK15308 Y   Drosophila virilis   Dvir\GJ14657 Y   Drosophila mojavensis   Dmoj\GI14224 Y   Drosophila grimshawi   Dgri\GH12170 Y
Orthologs in non-Drosophila Dipterans (EOG6K9BMN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010708   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010709   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010553   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014520
Orthologs in non-Dipteran Insects (EOG6F7MFB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40554   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG024160   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22568   Atta cephalotes Leafcutter ant  Acep\ACEP11809   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18834   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20748   Linepithema humile Argentine ant  Lhum\LH24278   Linepithema humile Argentine ant  Lhum\LH22901   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19188   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19187   Solenopsis invicta Red fire ant  Sinv\SINV21383   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008338   Bombyx mori Silkmoth  Bmor\BGIBMGA001251   Bombyx mori Silkmoth  Bmor\BGIBMGA001250   Pediculus humanus Human body louse  Phum\PHUM503450   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08270
Orthologs in non-Insect Arthropods (EOG68CZ9P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW001350   Ixodes scapularis Deer tick  Isca\ISCW001349
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15773 Drosophila sechellia Dsec\GM22512 Drosophila erecta Dere\GG19360 Drosophila yakuba Dyak\GE16008 Drosophila pseudoobscura pseudoobscura Dpse\GA27869 Drosophila persimilis Dper\GL20678 Drosophila willistoni Dwil\GK15308 Drosophila virilis Dvir\GJ14657 Drosophila mojavensis Dmoj\GI14224 Drosophila grimshawi Dgri\GH12170
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	27718 y1 v1; P{TRiP.JF02799}attP2 33653 y1 sc* v1; P{TRiP.HMS00059}attP2
Kyoto	103741 y* w* P{GawB}CycDNP0748 / FM7c
VDRC	v105361 P{KK108447}VIE-260B v29023 w1118; P{GD14114}v29023 v29024 w1118; P{GD14114}v29024
Genomic Clones ( 1 )
	BACR32K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 175 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22957
Other clones	DPiM_LD22957
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD02151 LD02948 LD05713 LD08812 LD19155 LD30358 LD31770 LD32135 LD32136 LD32551 LD44055 RE03007 RE07214 RE10590 RE12429 RE15989 RE18220 RE18932 RE23657 RE27358 RE27638 RE29917 RE37666 RE40934 RE43038 RE43341 RE44172 RE46052 RE53446 RE58991 RE59774 RE59959 RE63324 RE64427 RE70639 RE71868 RE72414 RE72546
Other clones	44020 533875 CK01.9D.F8 CK01.80B.D1 CK01.91D.B10 CK01.98D.E6 CK01.108B.F3 CK01.111B.A6 CK01.112D.A6 CK01.128D.A2 CK01.130A.D7 EC28342 EC34140 EK000327 EK012256 EK062213 EK071739 EK076351 EK099833 EK100316 EK163259 EK227706 EN10330 EN12926 RP003013558 RP003017184 RP003017669 RP003029660 RP003032740 RP003046974 RP003052937 RP003054049 RP003057130 RP003063344 RP003077347 RP003084152 RP003087024 RP003089355 RP003089423 RP003092305 RP003094259 RP003102546 RP003107547 RP003116569 RP003121916 RP003131967 RP003132218 RP003136499 RP003144056 RP003155759 RP003157576 RP003165172 RP003165956 RP003167126 RP003168459 RP003173777 RP003186229 RP003188984 RP003190576 RP003191231 RP003198851 RP003202849 RP003209509 RP003211384 RP003212069 RP003217463 RP003228695 RP003229055 RP003230427 RP003233831 RP003236551 RP003248020 RP003251281 RP003260172 RP003265898 RP003266098 RP003271870 RP003277347 RP003280812 RP003280880 RP003290803 RP003294519 RP003300791 RP003303723 RP003312740 RP003313145 RP003316783 RP003322633 RP003324104 RP003325447 RP003326334 RP003326675 RP003332497 RP003343962 RP003347593 RP003354859 RP003354977 RP003388336 RP003403871 RP003411521 RP003419756 RP003427996 RP003445154 RP003462596 RP003474757 RP003507588 RP003518528 RP003522187 RP003530956 RP003531586 RP003531771 RP003534312 RP003556428 RP003558957 RP003559074 RP003563889 RP003564311 RP003567155 RP003570784 RP003573570 RP003574502 RP003575599 RP003591293 RP003594211 RP003594221 RP003595699 RP003599684 RP003602027 RP003609890 RP003626782 RP003664573 RP003669710 RP003671406 RP003675639 RP003680694
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010315 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32551
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CycD CG9096 (Gong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) CycD is not required for progression through the G1 phase of the cell cycle. (Emmerich et al., 2004) The apparently indistinguishable phenotypes of CycD Cdk4 double mutants and either CycD or Cdk4 single mutant argue against major independent functions of CycD and Cdk4 in D.melanogaster. (Emmerich et al., 2004) CycD-Cdk4 is not a master regulator of the cell embryonic cell proliferation program. (Meyer et al., 2002) The primary function of CycD-Cdk4 is to stimulate growth. (Datar et al., 2000) Isolated by interaction with cdc2 and cdc2c using the interaction trap two hybrid system. (Finley et al., 1996) Yeast two-hybrid system has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits. CycD interacts with cdc2, cdc2c and Cdi11, and other human and S.cerevisiae cyclin-dependent kinases to activate transcription of a reporter gene, Ecol\lacZ. (Finley and Brent, 1994) The yeast interaction trap selection has been used to isolate cell cycle regulatory proteins that interact with cdc2 and cdc2c. CycD interacts with cdc2 and cdc2c. (Finley and Brent, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078631 NM_167472 NM_167473 RefSeq (Proteins) • NP_523355 NP_727912 NP_727913 DDBJ / EMBL / GenBank • AA817473 AAC47016 AAF48537 AAG13285 AAL39654 AAN09374 AAN09375 AF260583 AI455310 AY069509 U41808 Entrez Gene - A searchable database of RefSeq genes. • 32551 UniProtKB/TrEMBL • Q7KUZ5 Q9GTQ8 Q9VXM1 Q24158
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, C-terminal domain (IPR004367) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763) Cyclin D (IPR015451) Cyclin A/B/D/E (IPR014400) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22957
Linkouts
	BioGRID - A database of protein and genetic interactions • 58898 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010315 DroID - A comprehensive database of gene and protein interactions. • FBgn0010315 DRSC - Results from RNAi screens. • FBgn0010315 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010315 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9096-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010315 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32551 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/cyclind.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32551 modMine - Data generated by the modENCODE project. • FBgn0010315 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24158
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	Cdi3 (Finley et al., 1996, Zhong et al., 2003) CDI3 (Finley and Brent, 1993) cdi3   CG9096 (Keleman et al., 2009.8.5, Brandt, 2006, Perkins et al., 2009, Ni et al., 2010.12.1) cycD (Hipfner et al., 2002, Dong et al., 1997, Hyun et al., 2006, Bergman et al., 2007, Tsai and Sun, 2004, Zhai et al., 2012, Smith-Bolton et al., 2009, Genevet et al., 2009, Flannery et al., 2010, Datar et al., 2006, Pinto et al., 2011) CycD (Jones et al., 2006, Sanchez-Elsner et al., 2006, Nolo et al., 2006, Mukherjee et al., 2006, Friedman and Perrimon, 2006, Gilboa and Lehmann, 2006, Nedelsky et al., 2010, Nawaz et al., 2012, Buszczak et al., 2007, Berry and Baehrecke, 2007, Hueber et al., 2007, Vrailas and Moses, 2006, Kugler and Nagel, 2007, Lindquist et al., 2011, Maqbool et al., 2010, Toku et al., 2011, Buttitta et al., 2007, Dworkin et al., 2009, Hamaratoglu et al., 2009, Brandt, 2006, Greene et al., 2005, Khurana et al., 2006, Baonza and Freeman, 2005, Beam and Moberg, 2010, Reddy et al., 2010, Malzer et al., 2010, Gupta et al., 2008) CYCD (Arbouzova and Zeidler, 2006) cyclinD (Li and White, 2003, Gilbert et al., 2009, Gilbert et al., 2009) dCycD (Ji et al., 2012, Read et al., 2009, Delanoue et al., 2010) DmcycD (Zraly et al., 2004)
Name Synonym	cyclin D (Ren et al., 2004, Roy and Ingham, 2002, Foley and Sprenger, 2000, Tseng et al., 2007, Genevet et al., 2009) Cyclin D (Edgar, 2006, Vrailas et al., 2006, Thomas, 2005, Herr et al., 2007, Mandal et al., 2005, Secombe et al., 2007, Vrailas and Moses, 2006, Kugler and Nagel, 2007, Rafel and Milán, 2008, Khurana et al., 2006, Baltzer et al., 2009, Beam and Moberg, 2010, Gupta et al., 2008) CyclinD (Mukherjee et al., 2006, Baltzer et al., 2007, Reddy et al., 2010) cyclinD (Layalle et al., 2008, Sasai et al., 2007) Cyclin-dependent kinase interactor 3   dCyclinD (Read et al., 2009)
Secondary FlyBase IDs
References ( 149 )
Generate a list of	All references relating to this gene ( 149 )
List References by type	Research paper  ( 83 ) Supplementary material  ( 8 ) Review  ( 21 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 22 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 8 )
	Baker, 2013, PLoS ONE 8(3): e58266 Developmental Regulation of Nucleolus Size during Drosophila Eye Differentiation. [FBrf0220989] Icreverzi et al., 2012, Cell Cycle 11(3): 554--568 Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. [FBrf0217471] Ji et al., 2012, G3 (Bethesda) 2(12): 1651--1660 In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila. [FBrf0220353] Nawaz et al., 2012, PLoS ONE 7(5): e35640 Differential evolutionary wiring of the tyrosine kinase btk. [FBrf0218278] Zhai et al., 2012, PLoS Genet. 8(3): e1002582 Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859] Lindquist et al., 2011, Genome Res. 21(3): 433--446 Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] Pinto et al., 2011, EMBO J. 30(12): 2431--2444 RNA polymerase II kinetics in polo polyadenylation signal selection. [FBrf0213944] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...