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Gene Dmel\CycJ

General Information
Symbol	Dmel\CycJ	Species	D. melanogaster
Name	Cyclin J	Annotation symbol	CG10308
Feature type	protein_coding_gene	FlyBase ID	FBgn0010317
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Cdi5
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	63E1-63E1	Sequence location	3L:3,466,414..3,468,098 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclin J is referred to in FlyBase by the symbol Dmel\CycJ (CG10308, FBgn0010317). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cyclin-dependent protein kinase regulator activity. There is experimental evidence that it is involved in the biological process: mitotic cell cycle, embryonic; mitosis. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cyclin, C-terminal; Cyclin, N-terminal; Cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1640972_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CycJ. Gene sequence location is 3L:3466414..3468098.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN22903 HFA08653
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63E1-63E1   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63D2-63D3   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CycJ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Alternative translation stop created by use of multiphasic reading frames within coding region.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CycJ-RA FBtr0073127  NM_079179   1492   386 CycJ-RB FBtr0073128  NM_206267   1485   261
Additional Transcript Data & Comments
Reported size (kB)	1.6 (northern blot) (Finley et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CycJ-PA   FBpp0072987   45.1   386   6.51     NP_523903   AAF47776 CycJ-PB   FBpp0089168   30.8   261   9.07     NP_995989   AAS64959
Additional Polypeptide Data & Comments
Reported size (kDa)	391 (aa) (Finley et al., 1996) 50 (kD observed) (Kolonin and Finley, 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, C-terminal (IPR004367) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47776   AE014296 AAS64959   AC004356   AI064034   AI134916   AI515080   AW940166   AY058290 AAL13519   BP552630   BP552631   BQ103695   CO155014   EV581568   EV582090   EV585686   GH941903   GH943261   GH944876   GH946020   GH946633   GH948493   GH948809   GH949664   GH949927   GH950696   GH951779   GH952161   GH952598   GH952759   GH952765   GH953647   GH954195   GH954606   GH954719   GH955084   GH955236   GH956081   GH956355   GH956789   GH958508   GH959742   GH960131   GH960631   GH960993   GH961038   GH962042   GH962256   GH962278   GH962399   GH962966   GH963223   GH963298   GH964182   GH964281   GH964765   GH964918   GH965154   GH965246   GH965631   GH965747   GH965819   GH967549   GH967629   GH968699   GH969557   GH970608   GH971936   GH973499   GH973698   GH974139   GH974372   GH976408   GH977181   GH977207   GH977330   GH977422   GH978760   GH979008   GH980185   GH981018   GH982196   GH983216   GH983911   GH983955   U41809 AAC47017
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24159 Q95U62 Q9VZP3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Finley et al., 1996) adult stage | female     (Finley et al., 1996)
Additional Descriptive Data
	CycJ is maternally expressed. It is detected only in adult females and early embryos. (Finley et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 6     (Kolonin and Finley, 2000) Comment:reference states 0-3 hr AEL embryonic cycle 1 -- embryonic cycle 10     (Kolonin and Finley, 2000) embryonic stage 4     (Kolonin and Finley, 2000) adult stage | female   nurse cell   (Kolonin and Finley, 2000)   (Kolonin and Finley, 2000) unfertilized egg stage   unfertilized egg   (Kolonin and Finley, 2000)
Additional Descriptive Data
	CycJ protein is detected at high levels in the early embryo, during the first 10 nuclear cycles, but levels decline sharply thereafter. The protein is detected in the ovarian nurse cell cytoplasm in adult females, and is not detected in testes. (Kolonin and Finley, 2000)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010317    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010317 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010317 expression level Developmental Stage   Expression Level embryo 00-02hr    2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day    2028 adult female 30day    2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2074) embryo 02-04hr  (181) embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr  (125) pupae 2d postWPP  (116) pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day  (113) adult female 01day  (984) adult female 05day  (2028) adult female 30day  (2198) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2074) embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day  (2028) adult female 30day  (2198) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day    2028 adult female 30day    2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day    2028 adult female 30day    2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010317 expression level Developmental Stage   Expression Level embryo 00-02hr    2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day    2028 adult female 30day    2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2074) embryo 02-04hr  (181) embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr  125 pupae 2d postWPP  116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day  113 adult female 01day  (984) adult female 05day  (2028) adult female 30day  (2198) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day  2028 adult female 30day  2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day    2028 adult female 30day    2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2074 embryo 02-04hr    181 embryo 04-06hr    70 embryo 06-08hr    48 embryo 08-10hr    78 embryo 10-12hr    35 embryo 12-14hr    25 embryo 14-16hr    27 embryo 16-18hr    13 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    29 larva L1    19 larva L2    17 larva L3 12hr old    19 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    76 white prepupae new    83 white prepupae 12hr    72 white prepupae 24hr    125 pupae 2d postWPP    116 pupae 3d postWPP    81 pupae 4d postWPP    99 adult male 01day    65 adult male 05day    90 adult male 30day    113 adult female 01day    984 adult female 05day    2028 adult female 30day    2198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010317    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010317 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010317 expression level Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010317 expression level Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.775 Larval Midgut    4.1 Larval Hindgut    2.9 Larval Malpighian Tubules    3.4 Larval Fat Body    9.6 Larval Salivary Gland    1.4 Larval Trachea    1.85 Larval Carcass    1.375 Adult Head    7.4 Adult Eye    2.375 Adult Brain    24.1 Adult Thoracic-Abdominal Ganglion    21.9 Adult Crop    5.3 Adult Midgut    6.4 Adult Hindgut    3.4 Adult Malpighian Tubules    5.3 Adult Fat Body    6.9 Adult Salivary Gland no informative data Adult Heart    2.275 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    3.3 Adult Ovary    247.9 Adult Testis    12.2 Adult Male Accessory Gland    1.7 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.4   NA  Eye    2.375   NA  Brain    24.1   3.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    21.9   NA  Crop    5.3   4.1  Midgut    6.4   2.9  Hindgut    3.4   3.4  Malpighian Tubules    5.3   9.6  Fat Body    6.9   1.4  Salivary Gland    no informative data   NA  Heart    2.275   1.85  Trachea    NA   NA  VirginFemale Spermatheca    5.4   NA  InseminatedFemale Spermatheca    3.3   NA  Ovary    247.9   NA  Testis    12.2   NA  Male Accessory Gland    1.7   1.375  Carcass    8.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010317 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10308-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CycJ Stages(s) 1-3 Stages(s) 7-8
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CycJGD6936 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CycJ Class Mutagen Stocks Known lesion CycJA138 1 -- CycJDG29702 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CycJ Class Mutagen Stocks Known lesion CycJGD6936 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CycJg.C-term.T:Avic\GFP-EGFP in vitro construct - genomic fragment in vitro construct - coding region fusion 0 Yes CycJg.N-term.T:Avic\GFP-EGFP in vitro construct - genomic fragment in vitro construct - coding region fusion 0 Yes CycJKK102807 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CycJpMK4.Scer\UAS in vitro construct - regulatory fusion 0 Yes CycJScer\UAS.C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycJScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes CycJScer\UAS.N.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AJ14 (Althoff et al., 2009) Df(3L)armiΔ1 (Olivieri et al., 2010) Df(3L)Exel6095 (Ryder, 2004.4.26, Althoff et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6936} NA P{KK102807} NA P{UAS-CycJ.K} NA P{UAS-CycJ.pMK4} NA P{UAS-CycJ-EGFP} NA P{UAS-EGFP-CycJ} NA characterization construct P{gCycJ-EGFP} NA P{gEGFP-CycJ} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}CycJDG29702 NA PBac{5HPw+}CycJA138 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein kinase regulator activity inferred from direct assay (Finley et al., 1996)
Biological Process
CV term Evidence References
mitosis inferred from mutant phenotype (Kolonin and Finley, 2000) mitotic cell cycle, embryonic inferred from mutant phenotype (Kolonin and Finley, 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein kinase regulator activity inferred from sequence or structural similarity with UniProtKB:P47827 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR004367 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CycJ allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63921 DroID - A comprehensive database of gene and protein interactions. • FBgn0010317 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38428
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24212 Dgri\GH16117 Dmoj\GI12383 Dpse\GA28605 Dsec\GM14576 Dvir\GJ12272 Dwil\GK20516 Dyak\GE21368
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008256-PA Aedes aegypti (mosquito) AGAP002532-PA Anopheles gambiae (mosquito) XP_001944280.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008688-PA Bombyx mori (silk worm) ENSBTAP00000004744 Bos taurus (bovine) ENSCAFP00000012414 Canis familiaris (dog) CAGL0M11990g Candida glabrata (haploid yeast) CPIJ015384 Culex pipens (mosquito) ENSCPOP00000012727 Cavia porcellus (guinea pig) ENSCSAVP00000017549 Ciona savignyi (sedentary tunicate) 149145 Capitella spl (polychaete worm) ENSDARP00000078292 Danio rerio (zebra fish) ENSGACP00000003835 Gymnopilus aculeatus (mushroom) ENSGALP00000002208 Gallus gallus (chicken) ENSP00000265992 Homo sapiens (human) ISCW011019-PA Ixodes scapularis (deer tick) 119939 Lottia gigantea (owl limpet) ENSMODP00000005993 Monodelphis domestica (gray opossum) ENSMUSP00000025983 Mus musculus (house mouse) 81761 Nematostella vectensis (starlet anemone) ENSOANP00000024895 Ornithorynchus anatinus (platypus) ENSORLP00000000828 Oryzias latipes (japanese killifish) ENSPPYP00000002919 Pongo pygmaeus (orangutan) 81340 Phytophthora ramorum (sudden oak death pathogen) 141498 Phytophthora sojae (root rot pathogen) ENSPTRP00000029878 Pan troglodytes (chimpanzee) ENSRNOP00000019521 Rattus norvegicus (norway rat) XP_798281.2 Strongylocentrotus purpuratus (purple sea urchin) XP_001807694.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007304 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028401 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000026592 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW011019 FBgn0238630 FBgn0222513 FBgn0201358 FBgn0199521 FBgn0185469 FBgn0185468 FBgn0169497 FBgn0249964 FBgn0249965 FBgn0249227 FBgn0150857 FBgn0135140 FBgn0123588 FBgn0107398 FBgn0107397 FBgn0101206 CPIJ016049 CPIJ015384 BGIBMGA008688 ACYPI006224 AGAP002532 AAEL008256
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20525 y1 w67c23; P{wHy}CycJDG29702 16049 y1 w1118; PBac{5HPw+}CycJA138
VDRC	v31216 w1118; P{GD6936}v31216 v31217 w1118; P{GD6936}v31217
Genomic Clones ( 2 )
	BACR09B04 BACR22N09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 78 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04281
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12501 LD46761
Other clones	Dmel_dig_006722_0697_1380 Dmel_dig_010547_0642_2086 Dmel_dig_020492_0656_1064 EN05211 FGM219H04 RP004031560 RP004071287 RP004080993 RP004085806 RP004100268 RP004103551 RP004109367 RP004112037 RP004118208 RP004126608 RP004139719 RP004139805 RP004141884 RP004147869 RP004153702 RP004168801 RP004179907 RP004180034 RP004193303 RP004195745 RP004204127 RP004204368 RP004212779 RP004218016 RP004223802 RP004225008 RP004236693 RP004236998 RP004242972 RP004253087 RP004255146 RP004258410 RP004261172 RP004292017 RP004295614 RP004299019 RP004299555 RP004320104 RP004365046 RP004369720 RP004377380 RP004380537 RP004404844 RP004424755 RP004439844 RP004451992 RP004465529 RP004466144 RP004487289 RP004488150 RP004489395 RP004495510 RP004495989 RP004497817 RP004499973 RP004505870 RP004507714 RP004515999 RP004516530 RP004519300 RP004525543 RP004526487 RP004527688 RP004530468 RP004538858 RP004540101 RP004543679 RP004548659 RP004553781 UUGC1106
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010317 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38428
Antibody Information
	polyclonal (Kolonin and Finley, 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CycJ CG10308 (Yao, 1999.11)
Source for database merge of
Additional comments
Other Comments
	CycJ binds to cdc2 and not cdc2c. (Althoff et al., 2009) CycJ-deficient females with only one functional gene copy of CycA, CycB, CycB3 or CycE have a very similar fertility as those with two functional copies. (Althoff et al., 2009) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) CycJ is required for the early embryonic division cycles. (Kolonin and Finley, 2000) Isolated by interaction with cdc2 and cdc2c using the interaction trap two hybrid system. (Finley et al., 1996) Yeast two-hybrid system has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits. CycJ interacts with cdc2c and Cks30A, and S.cerevisiae cyclin-dependent kinase to activate transcription of a reporter gene, Ecol\lacZ. (Finley and Brent, 1994) The yeast interaction trap selection has been used to isolate cell cycle regulatory proteins that interact with cdc2 and cdc2c. CycJ interacts preferentially with cdc2c. (Finley and Brent, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079179 NM_206267 RefSeq (Proteins) • NP_523903 NP_995989 DDBJ / EMBL / GenBank • AAC47017 AAF47776 AAF47776.1 AAL13519 AAS64959 AAS64959.1 AC004356 AI064034 AW940166 AY058290 U41809 Entrez Gene - A searchable database of RefSeq genes. • 38428 UniProtKB/TrEMBL • Q9VZP3 Q95U62 Q24159
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, C-terminal (IPR004367) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63921 DroID - A comprehensive database of gene and protein interactions. • FBgn0010317 DRSC - Results from RNAi screens. • FBgn0010317 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010317 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10308-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010317 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38428 InParanoid A subset of ortholog calls from InParanoid. • AAEL008256-PA Aedes aegypti (mosquito) AGAP002532-PA Anopheles gambiae (mosquito) XP_001944280.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008688-PA Bombyx mori (silk worm) ENSBTAP00000004744 Bos taurus (bovine) ENSCAFP00000012414 Canis familiaris (dog) CAGL0M11990g Candida glabrata (haploid yeast) CPIJ015384 Culex pipens (mosquito) ENSCPOP00000012727 Cavia porcellus (guinea pig) ENSCSAVP00000017549 Ciona savignyi (sedentary tunicate) 149145 Capitella spl (polychaete worm) ENSDARP00000078292 Danio rerio (zebra fish) ENSGACP00000003835 Gymnopilus aculeatus (mushroom) ENSGALP00000002208 Gallus gallus (chicken) ENSP00000265992 Homo sapiens (human) ISCW011019-PA Ixodes scapularis (deer tick) 119939 Lottia gigantea (owl limpet) ENSMODP00000005993 Monodelphis domestica (gray opossum) ENSMUSP00000025983 Mus musculus (house mouse) 81761 Nematostella vectensis (starlet anemone) ENSOANP00000024895 Ornithorynchus anatinus (platypus) ENSORLP00000000828 Oryzias latipes (japanese killifish) ENSPPYP00000002919 Pongo pygmaeus (orangutan) 81340 Phytophthora ramorum (sudden oak death pathogen) 141498 Phytophthora sojae (root rot pathogen) ENSPTRP00000029878 Pan troglodytes (chimpanzee) ENSRNOP00000019521 Rattus norvegicus (norway rat) XP_798281.2 Strongylocentrotus purpuratus (purple sea urchin) XP_001807694.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007304 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028401 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000026592 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/cyclnj1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38428 modMine - Data generated by the modENCODE project. • FBgn0010317 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW011019 FBgn0238630 FBgn0222513 FBgn0201358 FBgn0199521 FBgn0185469 FBgn0185468 FBgn0169497 FBgn0249964 FBgn0249965 FBgn0249227 FBgn0150857 FBgn0135140 FBgn0123588 FBgn0107398 FBgn0107397 FBgn0101206 CPIJ016049 CPIJ015384 BGIBMGA008688 ACYPI006224 AGAP002532 AAEL008256
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Cdi5 (Finley et al., 1996, ) CDI5 (Finley and Brent, 1993) cdi5   CG10308 (Keleman et al., 2009.8.5) cycJ (Kolonin and Finley, 2000) CycJ (Olivieri et al., 2010) cyclinJ (Li and White, 2003)
Name Synonym	Cyclin-dependent kinase interactor 5   Cyclin J (Atikukke and Finley, 2007, Atikukke and Finley, 2008, Althoff et al., 2009) cyclin J (Atikukke and Finley, 2008)
Secondary FlyBase IDs
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Olivieri et al., 2010, EMBO J. 29(19): 3301--3317 An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. [FBrf0212004] Show all research papers ...