Open Close
General Information
Symbol
Dmel\Rac1
Species
D. melanogaster
Name
Rac1
Annotation Symbol
CG2248
Feature Type
FlyBase ID
FBgn0010333
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Rac, Drac1, Rac GTPase, Drac, RacA
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:1,300,879..1,302,683 [-]
Recombination map
3-0
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. (P40792)
Summaries
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Involved in axon outgrowth and myoblast fusion. Plays a role in regulating dorsal closure during embryogenesis. Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.
(UniProt, P40792)
Summary (Interactive Fly)
GTPase of the Ras superfamily - regulates cytoskeletal dynamics - controls epithelial tube length through the apical secretion and polarity pathways - Drk/Dos/Sos converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris - Rac1 acts downstream of integrin to control collective migration and lumen size in the Drosophila salivary gland
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Rac1 or the JBrowse view of Dmel\Rac1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0072730
1718
192
FBtr0331868
1805
192
Additional Transcript Data and Comments
Reported size (kB)
2.0 (northern blot)
2.2 (northern blot)
2.4 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0072614
21.4
192
8.46
FBpp0304252
21.4
192
8.46
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

192 aa isoforms: Rac1-PA, Rac1-PB
Additional Polypeptide Data and Comments
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus).
(UniProt, P40792)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rac1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (86 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from genetic interaction with FLYBASE:mbc; FB:FBgn0015513
inferred from direct assay
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
inferred from physical interaction with UniProtKB:A1Z7T0
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VF87
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
inferred from sequence or structural similarity
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
Biological Process (74 terms)
Terms Based on Experimental Evidence (67 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Pak3; FB:FBgn0044826
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Sra-1; FB:FBgn0038320
inferred from genetic interaction with FLYBASE:sli; FB:FBgn0264089
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rgk1; FB:FBgn0264753
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011, FLYBASE:Mtl; FB:FBgn0039532
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Fmr1; FB:FBgn0028734
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Sra-1; FB:FBgn0038320
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:ninaE; FB:FBgn0002940
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (14 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001178289
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002784640
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Rac1 protein is present in germline stem cells.
Rac1 is expressed in all developmental stages.
Rac1 is expressed ubiquitously in embryos.
Rac1 transcripts are detected throughout development with no significant fluctuations in transcript levels.
Rac1 is expressed throughout embryogenesis. After gastrulation, highest expression is detected in the mesoderm, the CNS and the hindgut primordium. Later expression is more uniform.
Rac1 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
germline stem cell

Comment: at the cap cell niche interface

immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Active GTP-bound Rac1 protein was localized to the germline stem cell - cap cell niche interface.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rac1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rac1
Transgenic constructs containing regulatory region of Rac1
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
actin filament & border follicle cell | somatic clone, with Scer\GAL4Act5C.PI
axon & dorsal cluster neuron, with Scer\GAL4ato.3.6
axon & dorsal cluster neuron | somatic clone
dendritic spine & lobular plate tangential neuron, with Scer\GAL4DB331
embryonic leading edge cell & actin filament, with Scer\GAL4en-e16E
filopodium & dendrite, with Scer\GAL4109(2)80
microchaeta & wing, with Scer\GAL4ptc-559.1
multidendritic neuron & dendrite, with Scer\GAL4477
multidendritic neuron & dendrite | supernumerary, with Scer\GAL4477
photoreceptor cell & axon, with Scer\GAL4GMR.PF
rhabdomere & actin filament, with Scer\GAL4unspecified
rhabdomere & microvillus, with Scer\GAL4unspecified
ventral adult lateral neuron & commissure
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
12 of 15
Yes
No
 
10 of 15
Yes
No
3 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
12 of 15
Yes
Yes
10 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
12 of 13
Yes
Yes
10 of 13
No
No
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
12 of 12
Yes
Yes
8 of 12
No
Yes
3 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (39)
14 of 15
Yes
Yes
13 of 15
No
Yes
12 of 15
No
Yes
8 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
11 of 15
Yes
Yes
10 of 15
No
Yes
4 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
6 of 9
No
No
6 of 9
No
Yes
6 of 9
No
Yes
6 of 9
No
No
6 of 9
No
No
5 of 9
No
No
5 of 9
No
Yes
5 of 9
No
No
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
4 of 15
Yes
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
2 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190FU7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila ananassae
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila willistoni
Drosophila virilis
Drosophila virilis
Drosophila mojavensis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BJE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D88 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CS8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (8)
8 of 10
7 of 10
6 of 10
3 of 10
2 of 10
2 of 10
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    suppressible
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus).
    (UniProt, P40792 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
    PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-0
    Cytogenetic map
    Sequence location
    3L:1,300,879..1,302,683 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    61F5-61F5
    Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    61F-61F
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (32)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (100)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Rac1 CG2248
    Source for database merge of
    Additional comments
    Other Comments
    Rac1 contributes to both passive memory decay and interference-induced forgetting.
    Rac1 is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.
    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
    Rac1 may function in both attractive and repulsive axon guidance.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Rac1 is partially responsible for mediating the Fmr1 effect on dendritic development.
    Rho1 and Rac1 mediate the dynamic rearrangement of actin in peripheral glia.
    Rac1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.
    ninaE appears to organise the actin cytoskeleton through Rac1 during rhabdomere morphogenesis.
    Reduced RacGAP50C or increased Rac1 activity in the wing disc cause similar defects: widening of veins, development of extra sensory organs, apoptosis and appearance of enlarged cells that differentiate multiple hairs with abnormal polarity.
    Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.
    ISNb growth cones and SNa axons require Rac1 for guidance to appropriate targets.
    The mbc product functions as a specific upstream regulator of Rac1 activity that mediates several morphogenetic processes in embryogenesis.
    Light and electron microscopy are used to study the process of myoblast fusion in Rac1 mutants.
    Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.
    Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.
    Expression of dominant inhibitory Rac1 disrupts the epidermal cell shape changes of dorsal closure by preventing a localised accumulation of actin and myosin that normally occurs in the epidermal cells flanking the amnioserosa. The accumulation of actin and myosin along the dorsal side of these cells is believed to drive the cell shape changes of dorsal closure.
    Both Rac1 and Rac2 proteins are marginally more like human Rac1 and Rac2, respectively, but the DNA sequences encoding them are more homologous to human Rac2 cDNA than that of human Rac1. This data does not readily allow the relationship between Rac1 and Rac2 and the genes encoding human Rac1 and Rac2 to be determined. Because of this the authors decided to assign new genes names using letters instead of 1 and 2 designators.
    Identified by sequence similarity to Rab3.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 111 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    Dm Rac1
    Rac
    (Sotillos et al., 2018, Vu et al., 2018, Wang et al., 2018, Yue et al., 2018, Czerniak et al., 2016, Orme et al., 2016, Flores-Benitez and Knust, 2015, Verboon et al., 2015, Das et al., 2013, Fernández-Espartero et al., 2013, Geisbrecht et al., 2013, Losick et al., 2013, Sotillos et al., 2013, Weavers and Skaer, 2013, Murray et al., 2012, Shuai et al., 2011, Tucker et al., 2011, Ball et al., 2010, Bunt et al., 2010, Cohen et al., 2010, Dorsten et al., 2010, Georgiou and Baum, 2010, Oliva and Sierralta, 2010, Renault et al., 2010, Wang et al., 2010, Wang et al., 2010, Jang et al., 2009, Liu et al., 2009, Parrish et al., 2009, Vlisidou et al., 2009, Woolworth et al., 2009, Beckett et al., 2008, Elwell et al., 2008, Lu et al., 2008, Matusek et al., 2008, Ng, 2008, Pirraglia and Myat, 2008, Rochlin et al., 2008, Warren-Paquin et al., 2008, Chen et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Gonda and Stronach, 2007, Ninov et al., 2007, Stronach et al., 2007, Tolwinski, 2007, Huelsmann et al., 2006, Long et al., 2006, Moncalvo and Campos, 2006, Montell, 2006, Pirraglia et al., 2006, Rothenfluh et al., 2006, Simoes et al., 2006, Talbot and VanBerkum, 2006, Bejsovec, 2005, Stramer et al., 2005, Stuart et al., 2005, Talbot and VanBerkum, 2005, Zhu et al., 2005, Avet-Rochex et al., 2004, Geisbrecht and Montell, 2004, Hardin and Walston, 2004, Inoue and Hayashi, 2004, Keung et al., 2004, Starz-Gaiano and Montell, 2004, Chihara et al., 2003, Donaldson, 2003, Hayashi et al., 2003, Jacinto and Baum, 2003, Kamiyama et al., 2003, Lecuit, 2003, Matani et al., 2003, Packard et al., 2003, Ribeiro et al., 2003, Schmucker, 2003, Tan et al., 2003, Thiery, 2003, Adler, 2002, Baum, 2002, Chen et al., 2002, Duchek and Rorth, 2002, Geisbrecht and Montell, 2002, Geisbrecht and Montell, 2002, Jhaveri and Rodrigues, 2002, Manning et al., 2002, Mlodzik, 2002, Park et al., 2002, Rorth, 2002, Schober and Perrimon, 2002, Strutt et al., 2002, Adler and Lee, 2001, Bashaw et al., 2001, Bashaw et al., 2001, Bee et al., 2001, Chen et al., 2001, Duchek et al., 2001, Fritz and VanBerkum, 2001, Fritz and Vanberkum, 2001, Gupta and Schupbach, 2001, Hu et al., 2001, Jacinto and Martin, 2001, Jacinto et al., 2001, Johnson et al., 2001, Montell, 2001, Pastor-Pareja et al., 2001, Pastor-Pareja et al., 2001, Raymond et al., 2001, Acebes and Ferrus, 2000, Bai et al., 2000, Bateman et al., 2000, Bothwell and Giniger, 2000, Caron, 2000, Chen et al., 2000, Fanto, 2000, Fanto et al., 2000, Gumbiner, 2000, Lin and Greenberg, 2000, Luo, 2000, Peifer and Tepass, 2000, Boutros and Mlodzik, 1999, Martin-Bermudo et al., 1999, Montell, 1999, Sutherland and Witke, 1999, Thomas and Wassarman, 1999, Crawford et al., 1998, Hall, 1998, O'Leary et al., 1998, Holland et al., 1997, Harden et al., 1996, Murphy and Montell, 1996, Guichard et al., 1995, Harden et al., 1995, Murphy and Montell, 1995, Tanaka and Sabry, 1995)
    Rac1
    (Kim et al., 2019, Nakano et al., 2019, Xu et al., 2019, Das et al., 2018, Garrido-Jimenez et al., 2018, Hassan et al., 2018, Medina, 2018, Richardson and Portela, 2018, Spinner et al., 2018, Toret et al., 2018, Tsai et al., 2018, Amourda and Saunders, 2017, Banisch et al., 2017, Chung et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Jang et al., 2017, Kannan et al., 2017, Lu et al., 2017, Nainu et al., 2017, Nakamura et al., 2017, Park et al., 2017, Transgenic RNAi Project members, 2017-, Winfree et al., 2017, Zheng et al., 2017, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Cervantes-Sandoval et al., 2016, Kuleesha et al., 2016, Lee and Schwarz, 2016, Levinson and Cagan, 2016, Ma et al., 2016, Roman-Fernandez and Bryant, 2016, Biersmith et al., 2015, Chen et al., 2015, Eikenes et al., 2015, Enomoto et al., 2015, Enomoto et al., 2015, Felix et al., 2015, Feng et al., 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Luo et al., 2015, Martín-Bermudo et al., 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rodal et al., 2015, Schreij et al., 2015, Song et al., 2015, Sundaram, 2015, Van Bortle et al., 2015, Verboon and Parkhurst, 2015, Vlisidou and Wood, 2015, Yuan et al., 2015, Abe et al., 2014, Abreu-Blanco et al., 2014, Bagley et al., 2014, Cai et al., 2014, Fernández et al., 2014, Goergen et al., 2014, Iordanou et al., 2014, Lammel et al., 2014, Lu et al., 2014, Morishita et al., 2014, Pereira et al., 2014, Salazar-Jaramillo et al., 2014, Swope et al., 2014, Das et al., 2013, Das et al., 2013, Eguchi et al., 2013, Geisbrecht et al., 2013, Jenkins et al., 2013, Khoo et al., 2013, Kwon et al., 2013, Melzer et al., 2013, Myant et al., 2013, Neisch et al., 2013, Parkhurst, 2013.10.2, Pickering et al., 2013, Pirraglia et al., 2013, Puram and Bonni, 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Vaque et al., 2013, Vaqué et al., 2013, Wan et al., 2013, Wang et al., 2013, Zhang et al., 2013, Zhang et al., 2013, Abmayr and Pavlath, 2012, Baek et al., 2012, Chartier et al., 2012, Duan et al., 2012, Etchegaray et al., 2012, Garcia et al., 2012, Howell et al., 2012, Humphreys et al., 2012, Iyer et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Lu et al., 2012, Marchal et al., 2012, Morris et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Shiratsuchi et al., 2012, Tsubouchi et al., 2012, Wang et al., 2012, Ziegenfuss et al., 2012, Zoller and Schulz, 2012, Brumby et al., 2011, Fauvarque and Williams, 2011, Goossens et al., 2011, Guest et al., 2011, Johnson et al., 2011, Kuzina et al., 2011, Lee and Thomas, 2011, Lee et al., 2011, Mirkovic et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Rohn et al., 2011, Tanaka et al., 2011, Taniguchi et al., 2011, Urbano et al., 2011, Ye et al., 2011, Ashton-Beaucage et al., 2010, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, D'Ambrosio and Vale, 2010, Djiane and Mlodzik, 2010, Elsaesser et al., 2010, Evans et al., 2010, Garlena et al., 2010, Guenin et al., 2010, Jones et al., 2010, Kim et al., 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Quinones et al., 2010, Sánchez-Soriano et al., 2010, Sato et al., 2010, Serio et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Singh et al., 2010, Warner, 2010.9.15, Asano et al., 2009, Bond and Foley, 2009, Frank et al., 2009, Gupta et al., 2009, Hashimoto et al., 2009, Hirano et al., 2009, Kuraishi et al., 2009, Tan et al., 2009, van Impel et al., 2009, Bakal et al., 2008, Geisbrecht et al., 2008, Johnson et al., 2008, Matusek et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Warren-Paquin et al., 2008, Avet-Rochex et al., 2007, Badrinath et al., 2007, Badrinath et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beckett and Baylies, 2007, Beltran et al., 2007, Betson and Settleman, 2007, Bruinsma et al., 2007, Colinet et al., 2007, Conder et al., 2007, Impel et al., 2007, Jovceva et al., 2007, Korolchuk et al., 2007, Li and Baker, 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Patel, 2007, Richardson et al., 2007, Stuart et al., 2007, Taniguchi et al., 2007, Taniguchi et al., 2007, Tountas and Fortini, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Blanke and Jackle, 2006, Chanut, 2006, Hozumi et al., 2006, Kerkhoff, 2006, Lovegrove et al., 2006, Nahm et al., 2006, Pipes et al., 2006, Pirraglia et al., 2006, Polaski et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Vasenkova et al., 2006, Williams et al., 2006, Avet-Rochex et al., 2005, Chen et al., 2005, Couceiro et al., 2005, Fernandes et al., 2005, Go, 2005, Pütz et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Rogers et al., 2003, Zelhof et al., 2003)
    Secondary FlyBase IDs
    • FBgn0014012
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (719)