FB2021_01, released Feb 18, 2021

Gene: Dmel\Rac1

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General Information
Symbol
Dmel\Rac1
Species
D. melanogaster
Name
Rac1
Annotation Symbol
CG2248
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010333
Gene Model Status
Current
Stock Availability
31 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

Rac, Drac1, Drac, Rac GTPase, D-Rac

Key Links
Genomic Location
Cytogenetic map
61F5-61F5
Sequence location
3L:1,300,879..1,302,683 [-]
Recombination map

3-0

RefSeq locus
NT_037436 REGION:1300879..1302683
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (88 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables GTPase activating protein binding
inferred from physical interaction with FLYBASE:RacGAP84C; FB:FBgn0045843
(Raymond et al., 2001)
enables GTPase activity
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
(Denholm et al., 2005)
inferred from genetic interaction with FLYBASE:mbc; FB:FBgn0015513
(Haralalka et al., 2011)
inferred from direct assay
(Raymond et al., 2001)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VF87
(assigned by UniProt )
(Schenck et al., 2003)
inferred from physical interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
(Dollar et al., 2016)
inferred from physical interaction with UniProtKB:A1Z7T0
(assigned by UniProt )
(Betson and Settleman, 2007, Lu and Settleman, 1999)
enables protein kinase binding
inferred from physical interaction with FLYBASE:Pak3; FB:FBgn0044826
(Mentzel and Raabe, 2005, Harden et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (73 terms)
Terms Based on Experimental Evidence (67 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Chang and Ready, 2000)
involved_in actin cytoskeleton reorganization
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011, FLYBASE:Mtl; FB:FBgn0039532
(Abreu-Blanco et al., 2014)
inferred from mutant phenotype
(Hornstein et al., 2003, Duchek et al., 2001)
involved_in actin filament bundle assembly
inferred from mutant phenotype
(Woolner et al., 2005)
involved_in actin filament organization
inferred from mutant phenotype
(Paladi and Tepass, 2004)
inferred from genetic interaction with FLYBASE:Pak3; FB:FBgn0044826
(Mentzel and Raabe, 2005)
involved_in activation of protein kinase activity
inferred from direct assay
(Mentzel and Raabe, 2005)
involved_in axon extension
inferred from mutant phenotype
(Srahna et al., 2006)
involved_in axon guidance
inferred from mutant phenotype
(Fan et al., 2003, Schenck et al., 2003, Fritz and VanBerkum, 2002)
inferred from genetic interaction with FLYBASE:sli; FB:FBgn0264089
(Fan et al., 2003)
inferred from genetic interaction with FLYBASE:Cyfip; FB:FBgn0038320
(Schenck et al., 2003)
involved_in axon midline choice point recognition
inferred from genetic interaction with FLYBASE:Sos; FB:FBgn0001965
(Yang and Bashaw, 2006)
involved_in axonal fasciculation
inferred from mutant phenotype
(Reeve et al., 2005)
involved_in border follicle cell migration
inferred from mutant phenotype
(Fernández-Espartero et al., 2013, Assaker et al., 2010, Medioni and Noselli, 2005)
involved_in cell competition in a multicellular organism
inferred from mutant phenotype
(Li and Baker, 2007)
involved_in cell morphogenesis
inferred from mutant phenotype
(D'Ambrosio and Vale, 2010)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Jean et al., 2012)
involved_in dendrite development
inferred from mutant phenotype
(Soba et al., 2015)
involved_in determination of digestive tract left/right asymmetry
inferred from mutant phenotype
(Taniguchi et al., 2007)
involved_in dorsal appendage formation
inferred from mutant phenotype
(Suzanne et al., 2001)
involved_in dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
involved_in dorsal closure, elongation of leading edge cells
inferred from mutant phenotype
(Woolner et al., 2005)
involved_in dorsal closure, spreading of leading edge cells
inferred from mutant phenotype
(Harden et al., 1996)
involved_in dorsal closure
inferred from mutant phenotype
(Denholm et al., 2005, Woolner et al., 2005)
inferred from mutant phenotype
(assigned by UniProt )
(Lu and Settleman, 1999)
involved_in embryonic anterior midgut (ectodermal) morphogenesis
inferred from mutant phenotype
(Taniguchi et al., 2007)
involved_in encapsulation of foreign target
inferred from mutant phenotype
(Sampson et al., 2012)
involved_in germ-band shortening
inferred from mutant phenotype
(Woolner et al., 2005)
involved_in glial cell migration
inferred from mutant phenotype
(Sepp and Auld, 2003)
involved_in head involution
inferred from mutant phenotype
(Woolner et al., 2005)
involved_in hemocyte development
inferred from mutant phenotype
(Ninov et al., 2007)
involved_in hemocyte migration
inferred from mutant phenotype
(Bunt et al., 2010, Olofsson and Page, 2005, Stramer et al., 2005, Paladi and Tepass, 2004)
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011
(Paladi and Tepass, 2004)
involved_in imaginal disc-derived wing hair site selection
inferred from mutant phenotype
(Eaton et al., 1996)
involved_in immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
inferred from direct assay
(Stuart et al., 2005)
involved_in JNK cascade
inferred from mutant phenotype
(Woolner et al., 2005)
involved_in lamellipodium assembly
inferred from mutant phenotype
(Woolner et al., 2005, Paladi and Tepass, 2004)
involved_in melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
involved_in memory
inferred from mutant phenotype
(Murakami et al., 2017, Shuai et al., 2010)
inferred from genetic interaction with FLYBASE:Rgk1; FB:FBgn0264753
(Murakami et al., 2017)
involved_in mesodermal cell migration
inferred from mutant phenotype
(van Impel et al., 2009)
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011, FLYBASE:Mtl; FB:FBgn0039532
(Wilson et al., 2005)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Dorsten et al., 2007)
involved_in muscle attachment
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011
(Liu et al., 2013)
involved_in muscle fiber development
inferred from mutant phenotype
(Fernandes et al., 2005)
involved_in myoblast fusion
inferred from mutant phenotype
(Fernandes et al., 2005)
involved_in myoblast proliferation
inferred from mutant phenotype
(Fernandes et al., 2005)
involved_in negative regulation of lamellipodium assembly
inferred from mutant phenotype
(Asano et al., 2009)
involved_in negative regulation of myotube cell migration
inferred from mutant phenotype
(Yang et al., 2020)
involved_in nephrocyte filtration
inferred from mutant phenotype
(Zhang et al., 2013)
involved_in neuron projection development
inferred from mutant phenotype
(Allen et al., 2000)
involved_in neuron projection morphogenesis
inferred from mutant phenotype
(Petsakou et al., 2015)
involved_in open tracheal system development
inferred from mutant phenotype
(Lovegrove et al., 2006)
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011
(Chihara et al., 2003)
involved_in peripheral nervous system development
inferred from mutant phenotype
(Sepp and Auld, 2003)
involved_in positive regulation of axon extension
inferred from genetic interaction with FLYBASE:DAAM; FB:FBgn0025641
(Gombos et al., 2015)
involved_in positive regulation of axon guidance
inferred from mutant phenotype
(Gombos et al., 2015)
involved_in positive regulation of border follicle cell migration
inferred from mutant phenotype
(Duchek et al., 2001)
involved_in positive regulation of cell-matrix adhesion
inferred from mutant phenotype
(Soba et al., 2015)
involved_in positive regulation of filopodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010)
involved_in positive regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Cdc42; FB:FBgn0010341, FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
involved_in positive regulation of protein serine/threonine kinase activity
inferred from direct assay
(assigned by UniProt )
(Lu and Settleman, 1999)
involved_in positive regulation of wound healing
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011, FLYBASE:Mtl; FB:FBgn0039532
(Abreu-Blanco et al., 2014)
involved_in regulation of adherens junction organization
inferred from mutant phenotype
(Bruinsma et al., 2007)
involved_in regulation of axonogenesis
inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712
(Ng and Luo, 2004)
involved_in regulation of dendrite morphogenesis
inferred from mutant phenotype
(Lee et al., 2003)
inferred from genetic interaction with FLYBASE:Fmr1; FB:FBgn0028734
(Lee et al., 2003)
involved_in regulation of locomotor rhythm
inferred from mutant phenotype
(Petsakou et al., 2015)
involved_in regulation of synapse assembly
inferred from mutant phenotype
(Allen et al., 2000)
involved_in regulation of synapse organization
inferred from mutant phenotype
(Schenck et al., 2003)
inferred from genetic interaction with FLYBASE:Cyfip; FB:FBgn0038320
(Schenck et al., 2003)
involved_in response to wounding
inferred from mutant phenotype
(Nakamura et al., 2017)
involved_in rhabdomere development
inferred from mutant phenotype
(Chang and Ready, 2000)
inferred from genetic interaction with FLYBASE:ninaE; FB:FBgn0002940
(Chang and Ready, 2000)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Pirraglia et al., 2006)
involved_in sensory perception of touch
inferred from mutant phenotype
(Tsubouchi et al., 2012)
involved_in tracheal outgrowth, open tracheal system
inferred from genetic interaction with FLYBASE:Rac2; FB:FBgn0014011
(Chihara et al., 2003)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Duchek et al., 2001)
inferred from genetic interaction with FLYBASE:Cdc42; FB:FBgn0010341, FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
involved_in ventral cord development
inferred from mutant phenotype
(Olofsson and Page, 2005)
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cortical cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in engulfment of apoptotic cell
inferred from biological aspect of ancestor with PANTHER:PTN001178289
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in establishment or maintenance of cell polarity
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in motor neuron axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN002784640
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of cell shape
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in small GTPase mediated signal transduction
inferred from electronic annotation with InterPro:IPR003578
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Mentzel and Raabe, 2005)
located_in extrinsic component of plasma membrane
inferred from direct assay
(Haralalka et al., 2011)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in rhabdomere
inferred from direct assay
(Chang and Ready, 2000)
located_in ruffle
inferred from direct assay
(Mentzel and Raabe, 2005)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cell projection
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasmic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in intracellular membrane-bounded organelle
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. (P40792)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
During various developmental processes, regulates changes in cell morphology in response to extracellular signals (PubMed:7958857, PubMed:10323867, PubMed:24855950). During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE-cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion between the leader border cells and nurse cells further promotes Rac1 signaling creating a positive feedback loop that amplifies the output of RTK activity and leads to higher Rac activity at the front, thus promoting polarization of the border cell cluster and directionally persistent migration (PubMed:24855950). Involved in axon outgrowth and myoblast fusion (PubMed:7958857). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867). Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes (PubMed:22547074).
(UniProt, P40792)
Summary (Interactive Fly)

GTPase of the Ras superfamily - regulates cytoskeletal dynamics - controls epithelial tube length through the apical secretion and polarity pathways - Drk/Dos/Sos converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris - Rac1 acts downstream of integrin to control collective migration and lumen size in the Drosophila salivary gland

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rac1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rac1-RA
FBtr0072730
NM_057602
1718
192
Rac1-RB
FBtr0331868
NM_001274318
1805
192
Additional Transcript Data and Comments
Reported size (kB)

2.0 (northern blot)

(Harden et al., 1995)

2.2 (northern blot)

(Hariharan et al., 1995)

2.4 (northern blot)

(Luo et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rac1-PA
FBpp0072614
21.4
192
8.46
NP_476950
AAF47469
Rac1-PB
FBpp0304252
21.4
192
8.46
NP_001261247
AGB93942
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

192 aa isoforms: Rac1-PA, Rac1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

192 (aa)

(Harden et al., 1995, Hariharan et al., 1995, Luo et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus).

(UniProt, P40792)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rac1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
germline stem cell
(Lu et al., 2012)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Sasamura et al., 1997)
(Hariharan et al., 1995)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Luo et al., 1994)
embryonic/larval digestive system
(Luo et al., 1994)
embryonic stage 10 -- 12
somatic mesoderm
(Luo et al., 1994)
blastoderm stage
organism | ubiquitous
(Luo et al., 1994)
embryonic stage -- adult stage
(Sasamura et al., 1997, Harden et al., 1995, Luo et al., 1994)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Raymond et al., 2004)
Additional Descriptive Data

Rac1 protein is present in germline stem cells.

(Lu et al., 2012)

Rac1 is expressed in all developmental stages.

(Sasamura et al., 1997)

Rac1 is expressed ubiquitously in embryos.

(Sasamura et al., 1997)

Rac1 transcripts are detected throughout development with no significant fluctuations in transcript levels.

(Harden et al., 1995)

Rac1 is expressed throughout embryogenesis. After gastrulation, highest expression is detected in the mesoderm, the CNS and the hindgut primordium. Later expression is more uniform.

(Hariharan et al., 1995)

Rac1 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.

(Luo et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
germline stem cell

Comment: at the cap cell niche interface

(Lu et al., 2012)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain
(Shuai et al., 2010)
adult mushroom body
(Shuai et al., 2010)
adult central complex
(Shuai et al., 2010)
larval stage
lamellocyte
(Xavier and Williams, 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Active GTP-bound Rac1 protein was localized to the germline stem cell - cap cell niche interface.

(Lu et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Mentzel and Raabe, 2005)
located_in extrinsic component of plasma membrane
inferred from direct assay
(Haralalka et al., 2011)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in rhabdomere
inferred from direct assay
(Chang and Ready, 2000)
located_in ruffle
inferred from direct assay
(Mentzel and Raabe, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rac1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rac1
Transgenic constructs containing regulatory region of Rac1
Aberrations (Deficiencies and Duplications) ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4109-79
lethal, with Scer\GAL4212
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4He.PZ
lethal, with Scer\GAL4hs.PB
lethal, with Scer\GAL4sd-SG29.1
lethal | female, with Scer\GAL4306
lethal | female, with Scer\GAL4458
lethal | heat sensitive
lethal - all die before end of first instar larval stage
lethal - all die before end of first instar larval stage, with Scer\GAL460
lethal - all die before end of first instar larval stage, with Scer\GAL4how-24B
lethal - all die before end of larval stage, with Scer\GAL4109-39
lethal - all die before end of larval stage, with Scer\GAL4how-24B
lethal - all die before end of pupal stage, with Scer\GAL4DB331
lethal - all die before end of pupal stage, with Scer\GAL4GMR.PF
lethal - all die before end of pupal stage, with Scer\GAL4srp.Hemo
lethal - all die during embryonic stage, with Scer\GAL460
lethal - all die during embryonic stage, with Scer\GAL469B
lethal - all die during embryonic stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage | recessive, with Scer\GAL4unspecified
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4198Y
viable, with Scer\GAL4212
viable, with Scer\GAL4306
viable, with Scer\GAL4458
viable, with Scer\GAL4hs.PB
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male semi-sterile
Other Phenotypes
Allele
abnormal cell death, with Scer\GAL4GR1
abnormal cell migration, with Scer\GAL4slbo.2.6
abnormal cell migration | embryonic stage 8, with Scer\GAL4twi.2PE
abnormal cell migration | embryonic stage 10, with Scer\GAL4VP16.nos.UTR
abnormal cell migration | embryonic stage, with Scer\GAL4447.2
abnormal cell number | larval stage, with Scer\GAL4He.PZ
abnormal cell polarity, with Scer\GAL4btl.PS
abnormal cell shape, with Scer\GAL4332.3
abnormal circadian behavior, with Scer\GAL4P0.5.Pdf
abnormal developmental rate, with Scer\GAL41151
abnormal immune response | larval stage
abnormal immune response | larval stage, with Scer\GAL4Hml.PG
abnormal learning | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal memory, with Scer\GAL4GMR13F02
abnormal memory | adult stage, with Scer\GAL4238Y
abnormal memory | adult stage, with Scer\GAL4c747
abnormal memory | adult stage, with Scer\GAL4D52H
abnormal memory | adult stage, with Scer\GAL4elav.PU
abnormal memory | adult stage, with Scer\GAL4ey-OK107
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL460
abnormal neuroanatomy, with Scer\GAL4109(2)80
abnormal neuroanatomy, with Scer\GAL4221
abnormal neuroanatomy, with Scer\GAL4477
abnormal neuroanatomy, with Scer\GAL4ato.3.6
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4eve.RN2
abnormal neuroanatomy, with Scer\GAL4ey-OK107
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy, with Scer\GAL4P0.5.Pdf
abnormal neuroanatomy, with Scer\GAL4SG18.1
abnormal neuroanatomy | adult stage, with Scer\GAL4DB331
abnormal neuroanatomy | dominant
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4ftz.ng
abnormal neuroanatomy | larval stage, with Scer\GAL41003.3
abnormal neuroanatomy | larval stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4109(2)80
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4BG380
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4elav.Switch.PO
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4RapGAP1-OK6
abnormal neurophysiology
abnormal neurophysiology | third instar larval stage, with Scer\GAL4BG380
abnormal neurophysiology | third instar larval stage, with Scer\GAL4RapGAP1-OK6
abnormal oxidative stress response, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
abnormal planar polarity
abnormal planar polarity, with Df(3L)Ar14-8, Scer\GAL4hs.2sev
abnormal planar polarity, with Scer\GAL4hs.2sev
abnormal planar polarity | adult stage, with Scer\GAL4hs.2sev
abnormal planar polarity | somatic clone, with Scer\GAL4hs.2sev
abnormal size, with Scer\GAL41151
abnormal size | adult stage, with Scer\GAL4GMR.PU
abnormal size | third instar larval stage, with Scer\GAL4BG380
abnormal size | third instar larval stage, with Scer\GAL4elav.Switch.PO
abnormal size | third instar larval stage, with Scer\GAL4elav-C155
abnormal size | third instar larval stage, with Scer\GAL4RapGAP1-OK6
abnormal starvation stress response, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
abnormal stress response, with Scer\GAL4ChAT.7.4, Scer\GAL80ts.αTub84B
abnormal stress response, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
abnormal touch response | larval stage, with Scer\GAL41003.3
chemical resistant, with Scer\GAL4NP1514
chemical sensitive, with Scer\GAL4NP1514
chemical sensitive | adult stage, with Scer\GAL4ics-G4
decreased cell number, with Scer\GAL41151
decreased cell number | adult stage, with Scer\GAL4hs.2sev
decreased cell number | larval stage, with Scer\GAL41151
decreased occurrence of cell division | larval stage, with Scer\GAL41151
increased cell growth | second instar larval stage | conditional, with Scer\GAL4ppk.PU
increased cell number | larval stage, with Scer\GAL4He.PZ
increased cell number | larval stage, with Scer\GAL4Hml.PG
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during embryonic stage, with Scer\GAL460
some die during embryonic stage, with Scer\GAL469B
some die during embryonic stage, with Scer\GAL4pnr-MD237
some die during embryonic stage | recessive, with Scer\GAL4unspecified
some die during first instar larval stage
some die during first instar larval stage, with Scer\GAL460
some die during first instar larval stage, with Scer\GAL4how-24B
some die during larval stage, with Scer\GAL4109-39
some die during larval stage, with Scer\GAL4how-24B
some die during pupal stage, with Scer\GAL4DB331
some die during pupal stage, with Scer\GAL4GMR.PF
some die during pupal stage, with Scer\GAL4srp.Hemo
visible
visible, with Df(3L)Ar14-8, Scer\GAL4hs.2sev
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4hs.2sev
visible, with Scer\GAL4LL54
visible, with Scer\GAL4sd-SG29.1
visible, with Scer\GAL4sev.EP
visible | adult stage, with Scer\GAL4GMR.long
visible | adult stage, with Scer\GAL4GMR.PU
wild-type
Phenotype manifest in
Allele
A1-7 lateral longitudinal muscle 1, with Scer\GAL41151
abdominal intersegmental nerve
abdominal intersegmental nerve, with Scer\GAL4elav.PLu
abdominal intersegmental nerve, with Scer\GAL4elav-C155
abdominal intersegmental nerve, with Scer\GAL4eve.RN2
abdominal segmental nerve
abdominal segmental nerve, with Scer\GAL4elav.PLu
abdominal segmental nerve, with Scer\GAL4elav-C155
aCC neuron, with Scer\GAL4eve.RN2
actin filament & border follicle cell | somatic clone, with Scer\GAL4Act5C.PI
adult antennal lobe commissure, with Scer\GAL4SG18.1
adult mushroom body
adult mushroom body, with Scer\GAL4ey-OK107
adult mushroom body (with Df(3L)Rac1)
adult mushroom body | somatic clone
adult mushroom body alpha-lobe, with Scer\GAL4ey-OK107
adult mushroom body beta-lobe, with Scer\GAL4ey-OK107
amnioserosa, with Scer\GAL4332.3
amnioserosa, with Scer\GAL4c381
amnioserosa, with Scer\GAL4hs.PB
antennal lobe, with Scer\GAL4SG18.1
axon, with Scer\GAL4elav-C155
axon & dorsal cluster neuron, with Scer\GAL4ato.3.6
axon & dorsal cluster neuron | somatic clone
border follicle cell
border follicle cell, with Scer\GAL4198Y
border follicle cell, with Scer\GAL4306
border follicle cell, with Scer\GAL4458
border follicle cell, with Scer\GAL4hs.PB
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell | somatic clone, with Scer\GAL4Act5C.PI
coxal tergal remotor muscle, with Scer\GAL41151
crystal cell, with Scer\GAL4He.PZ
dendrite
dendrite, with Scer\GAL4221
dendrite | dorsal | embryonic stage, with Scer\GAL460
dendrite | third instar larval stage, with Scer\GAL4109(2)80
dendritic arborizing neuron
dendritic arborizing neuron, with Scer\GAL4109(2)80
dendritic arborizing neuron, with Scer\GAL4477
dendritic spine & lobular plate tangential neuron, with Scer\GAL4DB331
denticle | ectopic, with Scer\GAL4wg.PM
dMP2 neuron, with Scer\GAL4ftz.ng
dorsal appendage, with Scer\GAL4CY2
dorsal appendage, with Scer\GAL4T155
dorsal cluster neuron | larval stage, with Scer\GAL4ppk.PG
dorsal group branch precursor, with Scer\GAL4btl.PS
dorsal medial indirect flight muscle, with Scer\GAL41151
dorsal trunk primordium, with Scer\GAL4btl.PS
egg chamber, with Scer\GAL4GR1
embryo | dorsal closure stage
embryo | dorsal closure stage, with Scer\GAL469B
embryo | dorsal closure stage, with Scer\GAL4332.3
embryo | dorsal closure stage, with Scer\GAL4c381
embryo | dorsal closure stage, with Scer\GAL4hs.PB
embryo | dorsal closure stage, with Scer\GAL4pnr-MD237
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4332.3
embryonic/first instar larval cuticle, with Scer\GAL4arm.PS
embryonic/first instar larval cuticle, with Scer\GAL4c381
embryonic/first instar larval cuticle, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle, with Scer\GAL4twi.PG
embryonic/first instar larval cuticle | dorsal, with Scer\GAL469B
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4pnr-MD237
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1
embryonic/larval anterior midgut, with Scer\GAL4NP3392
embryonic/larval cuticle | embryonic stage | maternal effect, with Scer\GAL4da.G32
embryonic/larval dorsal branch | embryonic stage, with Scer\GAL4btl.PS
embryonic/larval dorsal trunk | embryonic stage, with Scer\GAL4btl.PS
embryonic/larval ganglionic branch, with Scer\GAL4btl.PS
embryonic/larval hindgut, with Scer\GAL4how-24B
embryonic/larval hindgut, with Scer\GAL4NP2432
embryonic/larval midgut | embryonic stage, with Scer\GAL448Y
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4BG380
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav.Switch.PO
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4RapGAP1-OK6
embryonic/larval neuron, with Scer\GAL4unspecified
embryonic/larval pericardial cell, with Scer\GAL4Ugt36A1.PK
embryonic/larval somatic muscle, with Scer\GAL4how-24B
embryonic/larval spiracle primordium, with Scer\GAL4ems.HRE
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic/larval trachea, with Scer\GAL4how-24B
embryonic anterior Malpighian tubule, with Scer\GAL4crq.PO
embryonic dorsal epidermis, with Scer\GAL4en-e16E
embryonic dorsal epidermis, with Scer\GAL4unspecified
embryonic epidermis, with Scer\GAL4332.3
embryonic epidermis, with Scer\GAL4c381
embryonic epidermis, with Scer\GAL4hs.PB
embryonic hemocyte, with Scer\GAL4crq.PO
embryonic hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic leading edge cell & actin filament, with Scer\GAL4en-e16E
embryonic myoblast, with Scer\GAL4Mef2.5xCD
embryonic precursor cell of adult muscle, with Scer\GAL41151
embryonic segment, with Scer\GAL4en-e16E
eye
eye, with Df(3L)Ar14-8, Scer\GAL4hs.2sev
eye, with Scer\GAL4109-69
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye, with Scer\GAL4LL54
eye, with Scer\GAL4sev.EP
eye | adult stage, with Scer\GAL4GMR.long
eye | adult stage, with Scer\GAL4GMR.PU
eye | posterior, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4ey.PH
eye photoreceptor cell, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4hs.2sev
eye photoreceptor cell | somatic clone, with Scer\GAL4hs.2sev
filamentous actin, with Scer\GAL4ppk.PG
filopodium & dendrite, with Scer\GAL4109(2)80
follicle cell, with Scer\GAL4Act5C.PP
follicle cell, with Scer\GAL4GR1
germ band, with Scer\GAL4c381
germline cell | embryonic stage, with Scer\GAL4VP16.nos.UTR
giant axon
glial cell, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
hemocyte, with Scer\GAL4crq.PO
hemocyte, with Scer\GAL4He.PZ
hemocyte, with Scer\GAL4Hml.PG
hemocyte, with Scer\GAL4srp.Hemo
hindgut proper primordium, with Scer\GAL4how-24B
indirect flight muscle | larval stage, with Scer\GAL41151
interommatidial bristle
intersegmental nerve, with Scer\GAL4elav.PLu
intersegmental nerve, with Scer\GAL4elav-C155
intersegmental nerve, with Scer\GAL4eve.RN2
lamellipodium, with Scer\GAL4en-e16E
lamellocyte, with Scer\GAL4He.PZ
lamellocyte, with Scer\GAL4Hml.PG
lamina, with Scer\GAL4GMR.PF
larval dorsal multidendritic neuron ddaA | larval stage, with Scer\GAL41003.3
larval dorsal multidendritic neuron ddaC
larval multidendritic class I neuron, with Scer\GAL4221
larval multidendritic class I neuron | third instar larval stage, with Scer\GAL4109(2)80
larval multidendritic class IV neuron
larval multidendritic class IV neuron, with Scer\GAL4ppk.PG
lateral oblique dorsal muscle, with Scer\GAL41151
LNv neuron
lobe system of adult mushroom body
longitudinal connective, with Scer\GAL4elav-C155
longitudinal visceral muscle primordium, with Scer\GAL4447.2
macrochaeta, with Scer\GAL4sca-109-68
macrophage, with Scer\GAL4Cg.PA
macrophage, with Scer\GAL4Col4a1-A109.1F2.P
macrophage, with Scer\GAL4gcm-rA87.P
macrophage, with Scer\GAL4unspecified
medial longitudinal fascicle, with Scer\GAL4elav.PLu
medulla, with Scer\GAL4GMR.PF
melanotic mass, with Scer\GAL4He.PZ
melanotic mass, with Scer\GAL4Hml.PG
mesoderm | embryonic stage 8, with Scer\GAL4twi.2PE
mesothoracic intersegmental nerve, with Scer\GAL4eve.RN2
metathoracic intersegmental nerve, with Scer\GAL4eve.RN2
microchaeta & wing, with Scer\GAL4ptc-559.1
microtubule | third instar larval stage, with Scer\GAL4elav-C155
midgut primordium, with Scer\GAL4how-24B
midline crossing tract | embryonic stage 16, with Scer\GAL4ftz.ng
motor neuron, with Scer\GAL4elav.PLu
multidendritic neuron & dendrite, with Scer\GAL4477
multidendritic neuron & dendrite | supernumerary, with Scer\GAL4477
mushroom body pedunculus, with Scer\GAL4ey-OK107
myoblast, with Scer\GAL4how-24B
neurite
NMJ bouton | third instar larval stage, with Scer\GAL4BG380
NMJ bouton | third instar larval stage, with Scer\GAL4elav-C155
NMJ bouton | third instar larval stage, with Scer\GAL4RapGAP1-OK6
ommatidium
ommatidium, with Df(3L)Ar14-8, Scer\GAL4hs.2sev
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4hs.2sev
ommatidium | somatic clone, with Scer\GAL4hs.2sev
pCC neuron, with Scer\GAL4ftz.ng
peripheral glial cell
peripheral glial cell, with Scer\GAL4repo
photoreceptor
photoreceptor cell
photoreceptor cell, with Scer\GAL4GMR.PF
photoreceptor cell & axon, with Scer\GAL4GMR.PF
pigment cell
polar follicle cell, with Scer\GAL4slbo.2.6
presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS
presumptive embryonic salivary gland
presumptive embryonic salivary gland, with Scer\GAL4fkh.PH
prothoracic intersegmental nerve, with Scer\GAL4eve.RN2
retina, with Scer\GAL4GMR.PU
rhabdomere, with Scer\GAL4GMR.PU
rhabdomere, with Scer\GAL4unspecified
rhabdomere & actin filament, with Scer\GAL4unspecified
rhabdomere & microvillus, with Scer\GAL4unspecified
RP2 motor neuron, with Scer\GAL4eve.RN2
sensillum campaniformium, with Scer\GAL4en-e16E
sensory dendrite | larval stage, with Scer\GAL41003.3
s-LNv Pdf neuron, with Scer\GAL4P0.5.Pdf
stretch follicle cell, with Scer\GAL4Act5C.PP
tergosternal muscle, with Scer\GAL41151
tracheal branch primordium, with Scer\GAL4btl.PS
ventral adult lateral neuron & commissure
ventral midline of embryo, with Scer\GAL4elav.PLu
ventral midline of embryo, with Scer\GAL4en-e16E
ventral nerve cord, with Scer\GAL4unspecified
ventral nerve cord | embryonic stage, with Scer\GAL4158
ventral nerve cord | embryonic stage, with Scer\GAL4crq.PO
ventral nerve cord | embryonic stage, with Scer\GAL4elav-C155
ventral nerve cord commissure, with Scer\GAL4sim.PS
ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4ftz.ng
vesicle, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
visceral muscle fiber | embryonic stage, with Scer\GAL4sns.PK
vMP2 neuron, with Scer\GAL4ftz.ng
VUM neuron, with Scer\GAL4sim.PS
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4ptc-559.1
wing, with Scer\GAL4sd-SG29.1
wing blade anterior compartment, with Scer\GAL4ptc-559.1
wing disc, with Scer\GAL4ptc-559.1
wing vein, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RAC1
12 of 15
Yes
Yes
3  
Hsap\RAC2
12 of 15
Yes
Yes
1  
Hsap\RAC3
9 of 15
No
Yes
Hsap\RHOG
4 of 15
No
No
Hsap\CDC42
3 of 15
No
No
0  
Hsap\RHOQ
3 of 15
No
No
Hsap\RHOU
3 of 15
No
No
Hsap\RHOBTB3
2 of 15
No
Yes
Hsap\RHOF
2 of 15
No
Yes
Hsap\RHOJ
2 of 15
No
No
Hsap\RHOV
2 of 15
No
No
Hsap\RHOA
1 of 15
No
No
4  
Hsap\RHOB
1 of 15
No
No
1  
Hsap\RHOBTB1
1 of 15
No
No
Hsap\RHOBTB2
1 of 15
No
No
1  
Hsap\RHOC
1 of 15
No
No
1  
Hsap\RHOD
1 of 15
No
No
Hsap\RHOH
1 of 15
No
No
Hsap\RND1
1 of 15
No
Yes
Hsap\RND2
1 of 15
No
Yes
Hsap\RND3
1 of 15
No
Yes
Hsap\SLC2A3
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rac1
12 of 15
Yes
Yes
Mmus\Rac2
12 of 15
Yes
Yes
Mmus\Rac3
9 of 15
No
Yes
Mmus\Rhog
4 of 15
No
No
Mmus\Cdc42
3 of 15
No
No
Mmus\Rhoq
3 of 15
No
No
Mmus\Rhou
3 of 15
No
No
Mmus\Rhobtb3
2 of 15
No
Yes
Mmus\Rhof
2 of 15
No
Yes
Mmus\Rhoh
2 of 15
No
No
Mmus\Rhoj
2 of 15
No
No
Mmus\4930544G11Rik
1 of 15
No
No
Mmus\Rhoa
1 of 15
No
No
Mmus\Rhob
1 of 15
No
No
Mmus\Rhobtb1
1 of 15
No
No
Mmus\Rhobtb2
1 of 15
No
No
Mmus\Rhoc
1 of 15
No
No
Mmus\Rhod
1 of 15
No
No
Mmus\Rhov
1 of 15
No
No
Mmus\Rnd1
1 of 15
No
Yes
Mmus\Rnd2
1 of 15
No
Yes
Mmus\Rnd3
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
Rnor\Rac2
12 of 13
Yes
Yes
Rnor\Rac1
9 of 13
No
No
Rnor\Rhog
4 of 13
No
No
Rnor\Cdc42
3 of 13
No
No
Rnor\Rhoq
3 of 13
No
No
Rnor\Rac3
2 of 13
No
Yes
Rnor\Rhobtb3
2 of 13
No
Yes
Rnor\Rhof
2 of 13
No
Yes
Rnor\Rhoh
2 of 13
No
No
Rnor\Rhoj
2 of 13
No
No
Rnor\Rhou
2 of 13
No
Yes
Rnor\Rhov
2 of 13
No
No
Rnor\Rhoa
1 of 13
No
No
Rnor\Rhob
1 of 13
No
No
Rnor\Rhobtb1
1 of 13
No
No
Rnor\Rhobtb2
1 of 13
No
No
Rnor\Rhoc
1 of 13
No
No
Rnor\Rhod
1 of 13
No
No
Rnor\Rnd2
1 of 13
No
Yes
Rnor\Rnd3
1 of 13
No
Yes
Rnor\RSA-14-44
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\rac1
12 of 12
Yes
Yes
Xtro\rac2
8 of 12
No
Yes
Xtro\rhog
3 of 12
No
Yes
Xtro\rhoq
3 of 12
No
No
Xtro\rhou
3 of 12
No
No
Xtro\cdc42
2 of 12
No
No
Xtro\rac3
2 of 12
No
Yes
Xtro\rhof
2 of 12
No
Yes
Xtro\rhog
2 of 12
No
Yes
Xtro\rhoj
2 of 12
No
No
Xtro\rhov
2 of 12
No
No
Xtro\rhoa.2
1 of 12
No
No
Xtro\rhoa
1 of 12
No
No
Xtro\rhobtb1
1 of 12
No
No
Xtro\rhobtb2
1 of 12
No
No
Xtro\rhobtb3
1 of 12
No
Yes
Xtro\rhob
1 of 12
No
No
Xtro\rhoc
1 of 12
No
No
Xtro\rhoh
1 of 12
No
Yes
Xtro\rnd1
1 of 12
No
Yes
Xtro\rnd3
1 of 12
No
Yes
Danio rerio (Zebrafish) (41)
Drer\rac1a
13 of 15
Yes
Yes
Drer\rac1b
12 of 15
No
Yes
Drer\rac3b
11 of 15
No
Yes
Drer\rac2
7 of 15
No
Yes
Drer\wu:fb95b01
7 of 15
No
Yes
Drer\rac1l
6 of 15
No
Yes
Drer\rac3a
5 of 15
No
Yes
Drer\LOC100537765
4 of 15
No
Yes
Drer\rhoga
4 of 15
No
No
Drer\rhogb
4 of 15
No
No
Drer\rhogc
4 of 15
No
Yes
Drer\rhogd
4 of 15
No
Yes
Drer\cdc42
3 of 15
No
No
Drer\cdc42l2
3 of 15
No
No
Drer\cdc42l
3 of 15
No
No
Drer\rhoq
3 of 15
No
No
Drer\rhoua
3 of 15
No
No
Drer\rhoub
3 of 15
No
No
Drer\rhov
3 of 15
No
No
Drer\si:ch211-133l11.10
3 of 15
No
No
Drer\rhof
2 of 15
No
Yes
Drer\rhoh
2 of 15
No
No
Drer\rhoj
2 of 15
No
No
Drer\si:ch211-1f22.1
2 of 15
No
Yes
Drer\si:ch211-1f22.2
2 of 15
No
Yes
Drer\si:dkey-6b12.5
2 of 15
No
Yes
Drer\LOC100331257
1 of 15
No
No
Drer\rhoaa
1 of 15
No
No
Drer\rhoab
1 of 15
No
No
Drer\rhoac
1 of 15
No
No
Drer\rhobtb1
1 of 15
No
No
Drer\rhobtb2a
1 of 15
No
No
Drer\rhobtb2b
1 of 15
No
No
Drer\rhobtb4
1 of 15
No
No
Drer\rhoca
1 of 15
No
No
Drer\rhocb
1 of 15
No
No
Drer\rnd1a
1 of 15
No
Yes
Drer\rnd1b
1 of 15
No
Yes
Drer\rnd2
1 of 15
No
Yes
Drer\rnd3a
1 of 15
No
Yes
Drer\rnd3b
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\ced-10
10 of 15
Yes
Yes
Cele\rac-2
10 of 15
Yes
Yes
Cele\mig-2
4 of 15
No
No
Cele\cdc-42
3 of 15
No
No
Cele\chw-1
3 of 15
No
No
Cele\crp-1
3 of 15
No
Yes
Cele\rho-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\ARAC1
8 of 9
Yes
Yes
Atha\RAC6
8 of 9
Yes
Yes
Atha\ROP1
8 of 9
Yes
Yes
Atha\ARAC5
7 of 9
No
Yes
Atha\ARAC9
7 of 9
No
Yes
Atha\RAC2
7 of 9
No
Yes
Atha\RAC3
7 of 9
No
Yes
Atha\ROP2
7 of 9
No
Yes
Atha\RAC10
6 of 9
No
Yes
Atha\ROP9
6 of 9
No
Yes
Atha\ROP10
6 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\CDC42
2 of 15
Yes
No
1  
Scer\RHO1
1 of 15
No
No
Scer\RHO2
1 of 15
No
No
Scer\RHO3
1 of 15
No
No
Scer\RHO4
1 of 15
No
No
Scer\RHO5
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cdc42
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FU7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007257
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004528
Drosophila simulans
Dsim\GD13487
Drosophila simulans
Dsim\GD13056
Drosophila sechellia
Dsec\GM14225
Drosophila sechellia
Dsec\GM13759
Drosophila erecta
Dere\GG14611
Drosophila erecta
Dere\GG14963
Drosophila yakuba
Dyak\GE20972
Drosophila yakuba
Dyak\GE20412
Drosophila ananassae
Dana\GF23788
Drosophila ananassae
Dana\GF10067
Drosophila pseudoobscura pseudoobscura
Dpse\GA15321
Drosophila pseudoobscura pseudoobscura
Dpse\GA23612
Drosophila persimilis
Dper\GL24253
Drosophila willistoni
Dwil\GK20502
Drosophila willistoni
Dwil\GK16805
Drosophila virilis
Dvir\GJ13209
Drosophila virilis
Dvir\GJ12360
Drosophila mojavensis
Dmoj\GI12458
Drosophila mojavensis
Dmoj\GI12273
Drosophila grimshawi
Dgri\GH16613
Drosophila grimshawi
Dgri\GH16006
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BJE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023560
Musca domestica
House fly
Mdoa\17020470
Glossina morsitans
Tsetse fly
Gmor\GMOY004245
Glossina morsitans
Tsetse fly
Gmor\GMOY002179
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02472
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05965
Mayetiola destructor
Hessian fly
Mdes\Mdes007173
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009732
Anopheles darlingi
American malaria mosquito
Adar\ADAC004723
Anopheles gambiae
Malaria mosquito
Agam\AGAP005445
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D88 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006475
Bombyx mori
Silkmoth
Bmor\BGIBMGA007110
Bombyx mori
Silkmoth
Bmor\BGIBMGA012295
Danaus plexippus
Monarch butterfly
Dple\DPOGS210795-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203397-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210992-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016632
Heliconius melpomene
Postman butterfly
Hmel\HMEL025024
Heliconius melpomene
Postman butterfly
Hmel\HMEL007742
Apis florea
Little honeybee
Aflo\2477932532
Apis florea
Little honeybee
Aflo\2728460068
Apis florea
Little honeybee
Aflo\2154241108
Apis florea
Little honeybee
Aflo\2557575572
Apis mellifera
Western honey bee
Amel\GB45558
Apis mellifera
Western honey bee
Amel\GB45657
Apis mellifera
Western honey bee
Amel\GB55933
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12709
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15218
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17804
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18936
Bombus terrestris
Buff-tailed bumblebee
Bter\15216567
Bombus terrestris
Buff-tailed bumblebee
Bter\15211351
Bombus terrestris
Buff-tailed bumblebee
Bter\15208628
Bombus terrestris
Buff-tailed bumblebee
Bter\15216192
Linepithema humile
Argentine ant
Lhum\LH23269
Linepithema humile
Argentine ant
Lhum\LH15884
Linepithema humile
Argentine ant
Lhum\LH20173
Linepithema humile
Argentine ant
Lhum\LH17483
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0011f3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003131
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002966
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0018bc
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000948
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021442
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019951
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009052
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06840
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10346
Tribolium castaneum
Red flour beetle
Tcas\TC013187
Tribolium castaneum
Red flour beetle
Tcas\Rac1
Tribolium castaneum
Red flour beetle
Tcas\TC000961
Pediculus humanus
Human body louse
Phum\PHUM344070
Pediculus humanus
Human body louse
Phum\PHUM376850
Pediculus humanus
Human body louse
Phum\PHUM424410
Rhodnius prolixus
Kissing bug
Rpro\RPRC003442
Rhodnius prolixus
Kissing bug
Rpro\RPRC008853
Rhodnius prolixus
Kissing bug
Rpro\RPRC013286
Cimex lectularius
Bed bug
Clec\CLEC008884
Cimex lectularius
Bed bug
Clec\CLEC011807
Cimex lectularius
Bed bug
Clec\CLEC011605
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009526
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000070
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004385
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07397
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13055
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01188
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CS8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011334
Ixodes scapularis
Black-legged tick
Isca\ISCW016255
Ixodes scapularis
Black-legged tick
Isca\ISCW011749
Ixodes scapularis
Black-legged tick
Isca\ISCW003614
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77036.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61734.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68170.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g01600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g04000
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01520
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299952
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307551
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306746
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdc42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Racl1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rhop3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rac
Ciona intestinalis
Vase tunicate
Cint\LOC448958
Ciona intestinalis
Vase tunicate
Cint\LOC445702
Ciona intestinalis
Vase tunicate
Cint\LOC448957
Ciona intestinalis
Vase tunicate
Cint\rac3a
Ciona intestinalis
Vase tunicate
Cint\rac2
Gallus gallus
Domestic chicken
Ggal\RAC2
Gallus gallus
Domestic chicken
Ggal\CDC42
Gallus gallus
Domestic chicken
Ggal\RAC3
Gallus gallus
Domestic chicken
Ggal\RHOG
Gallus gallus
Domestic chicken
Ggal\RHOJ
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026995
Gallus gallus
Domestic chicken
Ggal\RAC1
Gallus gallus
Domestic chicken
Ggal\RHOQ
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Rac2
8 of 10
Mtl
7 of 10
Cdc42
6 of 10
Rho1
3 of 10
RhoBTB
3 of 10
RhoU
3 of 10
Miro
2 of 10
RhoL
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Rac1JF02813
model of  kidney disease
CEA
(Zhang et al., 2013)
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RAC1; Rac family small GTPase 1
12 of 15
602048
 
RAC2; Rac family small GTPase 2
12 of 15
602049
 
RAC3; Rac family small GTPase 3
9 of 15
602050
    RHOG; ras homolog family member G
    4 of 15
    179505
        CDC42; cell division cycle 42
        3 of 15
        116952
           
          RHOQ; ras homolog family member Q
          3 of 15
          605857
              RHOU; ras homolog family member U
              3 of 15
              606366
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Show neighbor-neighbor interactions:
                  Select Layout:
                  Legend:
                  Protein
                  RNA
                  Selected Interactor(s)
                  Interactions Browser
                  View in Interactions Browser
                  Please see the Physical Interaction reports below for full details
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  Rac1 - Arfip
                  anti tag coimmunoprecipitation, anti tag western blot, western blot
                  (Peru Y Colón de Portugal et al., 2012)
                  Rac1 - Cyfip
                  anti bait coimmunoprecipitation, western blot
                  (Schenck et al., 2003)
                  Rac1 - Fhos
                  pull down, anti tag western blot
                  (Lammel et al., 2014)
                  Rac1 - Frl
                  pull down, autoradiography
                  (Dollar et al., 2016)
                  Rac1 - GEFmeso
                  enzymatic study
                  (Sundaram, 2015)
                  Rac1 - Pak
                  pull down, autoradiography, western blot, two hybrid, anti tag western blot
                  (Nahm et al., 2006, Fan et al., 2003, Hornstein et al., 2003, Hu et al., 2001, Newsome et al., 2000, Harden et al., 1996)
                  Rac1 - Pak3
                  anti tag coimmunoprecipitation, western blot, anti tag western blot
                  (Duan et al., 2012, Mentzel and Raabe, 2005)
                  Rac1 - Pkn
                  pull down, western blot
                  (Betson and Settleman, 2007)
                  Rac1 - PlexB
                  pull down, autoradiography
                  (Driessens et al., 2001, Hu et al., 2001)
                  Rac1 - RhoGAP100F
                  pull down, anti tag western blot, enzymatic study, fluorescence technology
                  (Spinner et al., 2018)
                  Rac1 - RhoGAP18B
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Ojelade et al., 2015)
                  Rac1 - RhoGEF3
                  pull down, autoradiography
                  (Nakamura et al., 2017)
                  Rac1 - Whamy
                  pull down, anti tag western blot
                  (Brinkmann et al., 2016)
                  Rac1 - ics
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Ojelade et al., 2015)
                  Rac1 - pbl
                  enzymatic study, autoradiography
                  (van Impel et al., 2009)
                  Rac1 - scrib
                  anti tag coimmunoprecipitation, western blot
                  (Cervantes-Sandoval et al., 2016)
                  Rac1 - slpr
                  pull down, autoradiography, anti tag coimmunoprecipitation, western blot
                  (Garlena et al., 2010, Neisch et al., 2010)
                  Rac1 - trio
                  enzymatic study, autoradiography
                  (van Impel et al., 2009, Newsome et al., 2000)
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Rac1
                  suppressible
                  Abi
                  (Kim et al., 2019)
                  Rac1
                  suppressible
                  Act5C
                  (Geisbrecht and Montell, 2004)
                  Rac1
                  enhanceable
                  alph
                  (Baril et al., 2009)
                  Rac1
                  suppressible
                  alph
                  (Baril et al., 2009)
                  Rac1
                  suppressible
                  aos
                  (Fanto et al., 2000)
                  Rac1
                  enhanceable
                  Arf51F
                  (Neisch et al., 2013)
                  Rac1
                  enhanceable
                  bchs
                  (Raymond et al., 2004)
                  Rac2|Rac1
                  enhanceable
                  bnl
                  (Chihara et al., 2003)
                  Rac1
                  suppressible
                  bsk
                  (Baril et al., 2009, Srahna et al., 2006, Stronach and Perrimon, 2002, Fanto et al., 2000)
                  Rac2|Rac1
                  enhanceable
                  btl
                  (Chihara et al., 2003)
                  Rac1
                  enhanceable
                  bur
                  (Long et al., 2006)
                  Rac1
                  enhanceable
                  C3G
                  (Raymond et al., 2004)
                  Mtl|Rac1|Rac2
                  enhanceable
                  Cdc42
                  (Muñoz-Descalzo et al., 2007)
                  Rac1
                  suppressible
                  cdi
                  (Raymond et al., 2004)
                  Rac1
                  enhanceable
                  cdi
                  (Raymond et al., 2004)
                  Rac1
                  suppressible
                  Ced-12|mbc
                  (Geisbrecht et al., 2008)
                  Rac1
                  enhanceable
                  CG6701
                  (Raymond et al., 2004)
                  Rac1
                  enhanceable
                  CG7231
                  (Zhu et al., 2005)
                  Rac1
                  suppressible
                  CG10082
                  (Zhu et al., 2005)
                  Rac1
                  suppressible
                  chic
                  (Geisbrecht and Montell, 2004, Fritz and VanBerkum, 2002)
                  Rac1
                  enhanceable
                  ck
                  (Tan et al., 2003)
                  Rac1
                  enhanceable
                  conu
                  (Neisch et al., 2013)
                  Rac1
                  enhanceable
                  cpo
                  (Raymond et al., 2004)
                  Rac1
                  enhanceable
                  ct
                  (Jinushi-Nakao et al., 2007)
                  Rac1|Rac2
                  suppressible
                  cv-c
                  (Denholm et al., 2005)
                  Rac1
                  enhanceable
                  Cyfip
                  (Schenck et al., 2003)
                  Rac1
                  suppressible
                  Cyfip
                  (Schenck et al., 2003)
                  Rac1
                  suppressible
                  Dark
                  (Geisbrecht and Montell, 2004)
                  Rac1
                  enhanceable
                  dco
                  (Zhu et al., 2005)
                  Rac1
                  suppressible
                  Diap1
                  (Geisbrecht and Montell, 2004)
                  Rac1
                  suppressible
                  Diap2
                  (Geisbrecht and Montell, 2004)
                  Rac1
                  suppressible
                  Dronc
                  (Geisbrecht and Montell, 2004)
                  Rac1
                  enhanceable
                  Dsp1
                  (Zhu et al., 2005)
                  Rac1
                  enhanceable
                  Eip78C
                  (Zhu et al., 2005)
                  Rac1
                  enhanceable
                  EP1207
                  (Zhu et al., 2005)
                  Rac1
                  suppressible
                  EP2204
                  (Zhu et al., 2005)
                  Rac1
                  enhanceable
                  Fmr1
                  (Reeve et al., 2005, Schenck et al., 2003)
                  Rac1
                  suppressible
                  fra
                  (Dorsten et al., 2007)
                  Rac1
                  enhanceable
                  fra
                  (Dorsten et al., 2007)
                  Rac1
                  enhanceable
                  Frl
                  (Dollar et al., 2016)
                  Rac1
                  enhanceable
                  grp
                  (Raymond et al., 2004)
                  Mtl|Rac1|Rac2
                  suppressible
                  hep
                  (Woolner et al., 2005)
                  Rac1
                  suppressible
                  hep
                  (Stronach and Perrimon, 2002, Fanto et al., 2000)
                  Rac1
                  suppressible
                  hop
                  (Silver, 2005)
                  Rac1
                  suppressible
                  Jra
                  (Fanto et al., 2000, Hou et al., 1997)
                  Rac1
                  enhanceable
                  lilli
                  (Zhu et al., 2005)
                  Rac1
                  enhanceable
                  LIMK1
                  (Ng and Luo, 2004)
                  Rac1
                  suppressible
                  Mad
                  (Ball et al., 2010)
                  Rac1
                  suppressible
                  mbc
                  (Nolan et al., 1998)
                  Rac1
                  enhanceable
                  Mbs
                  (Tan et al., 2003)
                  Rac1
                  suppressible
                  msn
                  (Stronach and Perrimon, 2002)
                  Rac1|Rac2|DAAM
                  enhanceable
                  Mtl
                  (Matusek et al., 2008)
                  Rac1
                  suppressible
                  Mtl
                  (Muñoz-Descalzo et al., 2007)
                  Rac1
                  enhanceable
                  muc
                  (Raymond et al., 2004)
                  Rac1
                  suppressible
                  nmo
                  (Fanto et al., 2000)
                  Rac1
                  suppressible
                  numb
                  (Raymond et al., 2004)
                  Rac1|sli
                  suppressible
                  Pak
                  (Fan et al., 2003)
                  Rac1
                  suppressible
                  Pak
                  (Conder et al., 2004)
                  Rac1
                  enhanceable
                  Pax
                  (Chen et al., 2005)
                  Rac1
                  suppressible
                  pk
                  (Fanto et al., 2000)
                  Rac1
                  enhanceable
                  PlexB
                  (Hu et al., 2001)
                  Rac1
                  suppressible
                  poe
                  (Raymond et al., 2004)
                  Rac1
                  enhanceable
                  puc
                  (Baril et al., 2009, Taniguchi et al., 2007, Stronach and Perrimon, 2002)
                  Rac1
                  enhanceable
                  Rab11
                  (Assaker et al., 2010)
                  Rac1|DAAM
                  enhanceable
                  Rac2
                  (Matusek et al., 2008)
                  Rac1
                  enhanceable
                  Rac2
                  (Pirraglia et al., 2006)
                  Rac1
                  suppressible
                  RacGAP84C
                  (Raymond et al., 2001)
                  Rac1
                  suppressible
                  Rgk1
                  (Murakami et al., 2017)
                  Rac1
                  enhanceable
                  Rgk1
                  (Murakami et al., 2017)
                  Rac1
                  enhanceable
                  Rho1
                  (Fanto et al., 2000)
                  Rac1
                  suppressible
                  Rho1
                  (Tan et al., 2003, Fanto et al., 2000)
                  Rac1
                  suppressible
                  RhoGAP93B
                  (Hu et al., 2005)
                  Rac1
                  enhanceable
                  RhoGAP93B
                  (Hu et al., 2005)
                  Rac1|Rac2
                  suppressible
                  RhoGAP93B
                  (Lundstrom et al., 2004)
                  Rac1
                  enhanceable
                  RhoGEF3
                  (Couturier et al., 2017)
                  Rac1|Rac2
                  suppressible
                  robo1
                  (Lundstrom et al., 2004)
                  Rac1
                  enhanceable
                  robo1
                  (Fritz and VanBerkum, 2002)
                  Rac1
                  suppressible
                  Rok
                  (Tan et al., 2003)
                  Rac1
                  suppressible
                  shg
                  (Pirraglia et al., 2006)
                  Rac1
                  suppressible
                  shi
                  (Pirraglia et al., 2006)
                  Rac1
                  suppressible
                  slpr
                  (Baril et al., 2009, Stronach and Perrimon, 2002)
                  Rac1
                  enhanceable
                  SNF4Aγ
                  (Raymond et al., 2004)
                  Rac1
                  suppressible
                  Sos
                  (Lu et al., 2014)
                  Rac1
                  suppressible
                  sqh
                  (Tan et al., 2003)
                  Rac1
                  enhanceable
                  sqh
                  (Tan et al., 2003)
                  Rac1
                  suppressible
                  Stat92E
                  (Silver, 2005)
                  Rac2|Rac1
                  enhanceable
                  stumps
                  (Chihara et al., 2003)
                  Rac1
                  suppressible
                  tkv
                  (Ricos et al., 1999)
                  Rac1
                  enhanceable
                  Tlk
                  (Zhu et al., 2005)
                  Rac1
                  enhanceable
                  tou
                  (Zhu et al., 2005)
                  Rac1
                  suppressible
                  trc
                  (Emoto et al., 2004)
                  Rac1
                  suppressible
                  trio
                  (Ball et al., 2010, Geisbrecht and Montell, 2004, Bateman et al., 2000)
                  Rac1
                  enhanceable
                  tum
                  (Sotillos and Campuzano, 2000)
                  Rac1
                  suppressible
                  tum
                  (Sotillos and Campuzano, 2000)
                  Rac1
                  suppressible
                  upd1
                  (Silver, 2005)
                  Rac1
                  suppressible
                  Vang
                  (Fanto et al., 2000)
                  Rac1
                  suppressible
                  wit
                  (Kim et al., 2019, Ball et al., 2010)
                  Rac1
                  suppressible
                  zip
                  (Tan et al., 2003)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  btl
                  suppressible
                  Rac1
                  (Srahna et al., 2006)
                  Ced-12|mbc
                  suppressible
                  Rac1|Rac2
                  (Liu et al., 2013, Geisbrecht et al., 2008)
                  cindr
                  enhanceable
                  Mtl|Rac1|Rac2
                  (Johnson et al., 2008)
                  crb
                  suppressible
                  Rac1
                  (Harden et al., 2002)
                  ct
                  enhanceable
                  Rac1
                  (Jinushi-Nakao et al., 2007)
                  cv-c
                  enhanceable
                  Rac1|Rac2
                  (Denholm et al., 2005)
                  DAAM
                  enhanceable
                  Mtl|Rac1|Rac2
                  (Matusek et al., 2008)
                  DAAM
                  enhanceable
                  Rac1
                  (Gombos et al., 2015, Matusek et al., 2008)
                  DAAM
                  enhanceable
                  Rac1|Rac2
                  (Matusek et al., 2008)
                  dsh
                  suppressible
                  Rac1
                  (Srahna et al., 2006, Fanto et al., 2000)
                  egr
                  suppressible
                  Rac1
                  (Ruan et al., 2016)
                  egr
                  enhanceable
                  Rac1
                  (Ruan et al., 2016)
                  egr
                  suppressible
                  Mtl|Rac1|Rac2
                  (Ruan et al., 2016)
                  exp
                  suppressible
                  Rac1
                  (Iordanou et al., 2014)
                  Fmr1
                  enhanceable
                  Rac1
                  (Reeve et al., 2005, Schenck et al., 2003)
                  Fmr1
                  suppressible
                  Rac1
                  (Dong et al., 2016, Lee et al., 2003)
                  Frl
                  enhanceable
                  Rac1
                  (Dollar et al., 2016)
                  fs(1)h
                  suppressible
                  Rac1
                  (Bagley et al., 2014)
                  Hem
                  suppressible
                  Rac1
                  (Hummel et al., 2000)
                  hep
                  suppressible
                  Rac1
                  (Srahna et al., 2006)
                  ics
                  suppressible
                  Rac1
                  (Ojelade et al., 2015)
                  kn
                  enhanceable
                  Rac1
                  (Jinushi-Nakao et al., 2007)
                  Lar
                  enhanceable
                  Rac1
                  (Kaufmann et al., 1998)
                  LIMK1
                  suppressible
                  Rac1|Rac2
                  (Ng and Luo, 2004)
                  LIMK1
                  suppressible
                  Rac1
                  (Abe et al., 2014, Ng and Luo, 2004)
                  LIMK1
                  enhanceable
                  Rac1
                  (Ng and Luo, 2004)
                  LIMK1
                  enhanceable
                  Rac1|Rac2
                  (Ng and Luo, 2004)
                  mbc
                  suppressible
                  Rac1
                  (Haralalka et al., 2011)
                  msk
                  suppressible
                  Rac1
                  (Liu et al., 2013)
                  Mtl
                  enhanceable
                  Rac1
                  (Muñoz-Descalzo et al., 2007, Hakeda-Suzuki et al., 2002)
                  N
                  enhanceable
                  Rac1
                  (Song and Giniger, 2011)
                  N
                  suppressible
                  Mtl|Rac1|Rac2
                  (Song and Giniger, 2011)
                  N
                  suppressible
                  Rac1
                  (Kuzina et al., 2011)
                  ninaE
                  suppressible
                  Rac1
                  (Chang and Ready, 2000)
                  Pak
                  suppressible
                  Rac1|Rac2
                  (Ng and Luo, 2004)
                  pbl
                  enhanceable
                  Rac1
                  (van Impel et al., 2009)
                  pbl
                  suppressible
                  Mtl|Rac1|Rac2
                  (van Impel et al., 2009)
                  pbl
                  suppressible
                  Rac1
                  (Murray et al., 2012, van Impel et al., 2009)
                  PlexB
                  suppressible
                  Rac1
                  (Hu et al., 2001)
                  PsGEF
                  enhanceable
                  Rac1
                  (Higuchi et al., 2009)
                  Pten
                  suppressible
                  Rac1
                  (Pickering et al., 2013)
                  Pvr
                  enhanceable
                  Mtl|Rac1|Rac2
                  (Ishimaru et al., 2004)
                  Raf
                  suppressible
                  Rac1
                  (Sotillos and Campuzano, 2000)
                  RhoGAP18B
                  suppressible
                  Mtl|Rac1|Rac2
                  (Rothenfluh et al., 2006)
                  robo1
                  enhanceable
                  Rac1
                  (Fritz and VanBerkum, 2002)
                  Rtca
                  suppressible
                  Rac1
                  (Song et al., 2015)
                  rut
                  suppressible
                  Rac1
                  (Shuai et al., 2010)
                  Sbf
                  suppressible
                  Rac1
                  (Jean et al., 2012)
                  slpr
                  enhanceable
                  Mtl|Rac1|Rac2
                  (Polaski et al., 2006)
                  Sos
                  enhanceable
                  Rac1
                  (Fritz and VanBerkum, 2002)
                  ssh
                  suppressible
                  Rac1|Rac2
                  (Ng and Luo, 2004)
                  sti
                  suppressible
                  Rac1|Rac2
                  (D'Avino et al., 2004)
                  trc
                  suppressible
                  Rac1
                  (Emoto et al., 2004)
                  trc
                  enhanceable
                  Rac1
                  (He et al., 2005)
                  trio
                  suppressible
                  Rac1
                  (Hakeda-Suzuki et al., 2002)
                  trio
                  enhanceable
                  Rac1
                  (Newsome et al., 2000)
                  tum
                  suppressible
                  Mtl|Rac1|Rac2
                  (D'Avino et al., 2004)
                  Vang
                  suppressible
                  Rac1
                  (Gombos et al., 2015)
                  Vps35
                  suppressible
                  Rac1
                  (Korolchuk et al., 2007)
                  Wnt5
                  suppressible
                  Rac1
                  (Gombos et al., 2015)
                  wun2|wun
                  suppressible
                  Rac1
                  (Renault et al., 2010)
                  External Data
                  Subunit Structure (UniProtKB)
                  Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus).
                  (UniProt, P40792 )
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Pvr Signaling Pathway Core Components -
                  PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
                  Metabolic Pathways
                  External Data
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3L
                  Recombination map

                  3-0

                  Cytogenetic map
                  61F5-61F5
                  Sequence location
                  3L:1,300,879..1,302,683 [-]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  61F5-61F5
                  Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  61F-61F
                  (determined by in situ hybridisation)
                  (Sasamura et al., 1997, Sasamura, 1995)
                  61F5-61F5
                  (Harden et al., 1995)
                  Experimentally Determined Recombination Data
                  Location

                  3-0

                  (FlyBase, 2016)

                  3-1.7

                  (Comeron et al., 2012)

                  3-

                  (Harden, 1994.8.2)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (31)
                  Genomic Clones (17)
                   

                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                  cDNA Clones (100)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Rac1 CG2248

                  (Gu, 1999.11)
                  Source for database merge of
                  Additional comments
                  Other Comments

                  Rac1 contributes to both passive memory decay and interference-induced forgetting.

                  (Shuai et al., 2010)

                  Rac1 is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.

                  (Li and Baker, 2007)

                  S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                  (Stroschein-Stevenson et al., 2006)

                  Rac1 may function in both attractive and repulsive axon guidance.

                  (Fan et al., 2003)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  Rac1 is partially responsible for mediating the Fmr1 effect on dendritic development.

                  (Lee et al., 2003)

                  Rho1 and Rac1 mediate the dynamic rearrangement of actin in peripheral glia.

                  (Sepp and Auld, 2003)

                  Rac1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.

                  (Fritz and VanBerkum, 2002)

                  ninaE appears to organise the actin cytoskeleton through Rac1 during rhabdomere morphogenesis.

                  (Chang and Ready, 2000)

                  Reduced RacGAP50C or increased Rac1 activity in the wing disc cause similar defects: widening of veins, development of extra sensory organs, apoptosis and appearance of enlarged cells that differentiate multiple hairs with abnormal polarity.

                  (Sotillos and Campuzano, 2000)

                  Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.

                  (Agnes et al., 1999)

                  ISNb growth cones and SNa axons require Rac1 for guidance to appropriate targets.

                  (Kaufmann et al., 1998)

                  The mbc product functions as a specific upstream regulator of Rac1 activity that mediates several morphogenetic processes in embryogenesis.

                  (Nolan et al., 1998)

                  Light and electron microscopy are used to study the process of myoblast fusion in Rac1 mutants.

                  (Doberstein et al., 1997)

                  Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.

                  (Glise and Noselli, 1997)

                  Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.

                  (Murphy and Montell, 1996)

                  Expression of dominant inhibitory Rac1 disrupts the epidermal cell shape changes of dorsal closure by preventing a localised accumulation of actin and myosin that normally occurs in the epidermal cells flanking the amnioserosa. The accumulation of actin and myosin along the dorsal side of these cells is believed to drive the cell shape changes of dorsal closure.

                  (Harden et al., 1995)

                  Both Rac1 and Rac2 proteins are marginally more like human Rac1 and Rac2, respectively, but the DNA sequences encoding them are more homologous to human Rac2 cDNA than that of human Rac1. This data does not readily allow the relationship between Rac1 and Rac2 and the genes encoding human Rac1 and Rac2 to be determined. Because of this the authors decided to assign new genes names using letters instead of 1 and 2 designators.

                  (Harden et al., 1995)

                  Identified by sequence similarity to Rab3.

                  (Sasamura et al., 1995)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 83 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DPiM - Drosophila Protein interaction map
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (31)
                  Reported As
                  Symbol Synonym
                  2248
                  (Ravi et al., 2009)
                  CG2248
                  (Hassan et al., 2018, Abmayr and Pavlath, 2012, Christis and Munro, 2012, Howell et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Seinen et al., 2010, Perkins et al., 2009, Colicelli, 2004, Rogers et al., 2003)
                  D-Rac
                  (Tear, 1999, Knust, 1997)
                  D-Rac 1
                  (Mentzel et al., 2003)
                  D-Rac1
                  (Ryabinina et al., 2006, Ip and Davis, 1998)
                  DRac
                  (Dorsten et al., 2007, Hornstein et al., 2003, Weitzman, 2000, den Hertog, 1999, Forbes and Lehmann, 1999, Hacker and Perrimon, 1998)
                  DRac1
                  (Turkel et al., 2015, Blanke and Jackle, 2006, Sanchez-Soriano and Prokop, 2005, Polesello and Payre, 2004, Xia and Karin, 2004, Zarske and Hafen, 2003, Dobens and Raftery, 2001, Dobens et al., 2001, Sone et al., 2001, Allen et al., 2000, Dobens et al., 2000, Paladi and Tepass, 2000, Sotillos and Campuzano, 2000, Montell, 1999, Sawamoto et al., 1999, Martin-Blanco, 1997, Van Aelst and D'Souza-Schorey, 1997)
                  DRacA
                  (Anonymous, 1995, Harden et al., 1995)
                  Dm Rac1
                  (Jekely, 2003)
                  DmRAC
                  (Piekny et al., 2005)
                  DmRAC1
                  (Mentzel and Raabe, 2005)
                  Dmrac1
                  (Harden et al., 1993)
                  Drac
                  (Chen and Olson, 2005, Fritz and VanBerkum, 2002, Sem et al., 2002, Muller, 2000, Goberdhan and Wilson, 1998, Hou et al., 1997)
                  Drac1
                  (Dong et al., 2016, Shuai et al., 2011, Shuai et al., 2010, Wang et al., 2009, Inoue and Hayashi, 2007, He et al., 2005, Polesello et al., 2005, Chen and Olson, 2004, Zhai et al., 2004, Kim et al., 2003, Harden et al., 2002, Langmann et al., 2002, Noselli, 2002, Van Aelst and Symons, 2002, Bateman and Van Vactor, 2001, Luginbuhl et al., 2001, Raymond et al., 2001, Stoker, 2001, Suzanne et al., 2001, Zarske et al., 2001, Allen et al., 2000, Benlali et al., 2000, Chang and Ready, 2000, Colley, 2000, Dobens and Raftery, 2000, Hummel et al., 2000, Raymond et al., 2000, Stronach and Perrimon, 2000, Agnes and Noselli, 1999, Agnes and Noselli, 1999, Agnes et al., 1999, Gao et al., 1999, Harden et al., 1999, Harden et al., 1999, Kuang et al., 1999, Noselli and Agnes, 1999, Paululat et al., 1999, Paululat et al., 1999, Ricos et al., 1999, Ricos et al., 1999, Rietveld et al., 1999, Stronach and Perrimon, 1999, Bateman et al., 1998, Crawford et al., 1998, Kaufmann et al., 1998, Noselli, 1998, Takahashi et al., 1998, Zohn et al., 1998, Doberstein et al., 1997, Luo et al., 1997, Sone et al., 1997, Doberstein et al., 1996, Abmayr et al., 1995, Brand and Dormand, 1995, Eaton et al., 1995, Luo et al., 1995, Luo, 1994.7.5, Luo et al., 1994, Luo et al., 1993)
                  Drac1a
                  (Sasamura et al., 1997, Sasamura et al., 1995)
                  DracA
                  (Fields and Montell, 2001)
                  GTPase Rac1
                  (Zhang and Broadie, 2005)
                  P40792
                  (Rojas et al., 2012)
                  RAC1
                  (Mariano et al., 2020, Losada-Perez, 2018, Ashton-Beaucage et al., 2016, Freeman, 2015, Mirey et al., 2003)
                  Rac
                  (Wolterhoff et al., 2020, Grendler et al., 2019, Sotillos et al., 2018, Vu et al., 2018, Wang et al., 2018, Yue et al., 2018, Koch et al., 2017, Czerniak et al., 2016, Orme et al., 2016, Flores-Benitez and Knust, 2015, Verboon et al., 2015, Das et al., 2013, Fernández-Espartero et al., 2013, Geisbrecht et al., 2013, Losick et al., 2013, Sotillos et al., 2013, Weavers and Skaer, 2013, Murray et al., 2012, Shuai et al., 2011, Tucker et al., 2011, Ball et al., 2010, Bunt et al., 2010, Cohen et al., 2010, Dorsten et al., 2010, Georgiou and Baum, 2010, Oliva and Sierralta, 2010, Renault et al., 2010, Wang et al., 2010, Wang et al., 2010, Jang et al., 2009, Liu et al., 2009, Parrish et al., 2009, Vlisidou et al., 2009, Woolworth et al., 2009, Beckett et al., 2008, Elwell et al., 2008, Lu et al., 2008, Matusek et al., 2008, Ng, 2008, Pirraglia and Myat, 2008, Rochlin et al., 2008, Warren-Paquin et al., 2008, Chen et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Gonda and Stronach, 2007, Ninov et al., 2007, Stronach et al., 2007, Tolwinski, 2007, Huelsmann et al., 2006, Long et al., 2006, Moncalvo and Campos, 2006, Montell, 2006, Pirraglia et al., 2006, Rothenfluh et al., 2006, Simoes et al., 2006, Talbot and VanBerkum, 2006, Bejsovec, 2005, Stramer et al., 2005, Stuart et al., 2005, Talbot and VanBerkum, 2005, Zhu et al., 2005, Avet-Rochex et al., 2004, Geisbrecht and Montell, 2004, Hardin and Walston, 2004, Inoue and Hayashi, 2004, Keung et al., 2004, Starz-Gaiano and Montell, 2004, Chihara et al., 2003, Donaldson, 2003, Hayashi et al., 2003, Jacinto and Baum, 2003, Kamiyama et al., 2003, Lecuit, 2003, Matani et al., 2003, Packard et al., 2003, Ribeiro et al., 2003, Schmucker, 2003, Tan et al., 2003, Thiery, 2003, Adler, 2002, Baum, 2002, Chen et al., 2002, Duchek and Rorth, 2002, Geisbrecht and Montell, 2002, Geisbrecht and Montell, 2002, Jhaveri and Rodrigues, 2002, Manning et al., 2002, Mlodzik, 2002, Park et al., 2002, Rorth, 2002, Schober and Perrimon, 2002, Strutt et al., 2002, Adler and Lee, 2001, Bashaw et al., 2001, Bashaw et al., 2001, Bee et al., 2001, Chen et al., 2001, Duchek et al., 2001, Fritz and VanBerkum, 2001, Fritz and Vanberkum, 2001, Gupta and Schupbach, 2001, Hu et al., 2001, Jacinto and Martin, 2001, Jacinto et al., 2001, Johnson et al., 2001, Montell, 2001, Pastor-Pareja et al., 2001, Pastor-Pareja et al., 2001, Raymond et al., 2001, Acebes and Ferrus, 2000, Bai et al., 2000, Bateman et al., 2000, Bothwell and Giniger, 2000, Caron, 2000, Chen et al., 2000, Fanto, 2000, Fanto et al., 2000, Gumbiner, 2000, Lin and Greenberg, 2000, Luo, 2000, Peifer and Tepass, 2000, Boutros and Mlodzik, 1999, Martin-Bermudo et al., 1999, Montell, 1999, Sutherland and Witke, 1999, Thomas and Wassarman, 1999, Crawford et al., 1998, Hall, 1998, O'Leary et al., 1998, Holland et al., 1997, Harden et al., 1996, Murphy and Montell, 1996, Guichard et al., 1995, Harden et al., 1995, Murphy and Montell, 1995, Tanaka and Sabry, 1995)
                  Rac GTPase
                  (Castellani and Rougon, 2002, Petit et al., 2002)
                  Rac-1
                  (Hardie, 2003)
                  Rac1
                  (Iwashita et al., 2020, Kikuchi et al., 2020, La Marca and Richardson, 2020, Nakamura et al., 2020, Popkova et al., 2020, Ramond et al., 2020, Robinson et al., 2020, Sun et al., 2020, Yoong et al., 2020, Banerjee et al., 2019, Boucher et al., 2019, Butts et al., 2019, Drummond-Barbosa, 2019, Gao et al., 2019, Kim et al., 2019, Lee and Chen, 2019, Nakano et al., 2019, Schumacher, 2019, Silver et al., 2019, Tenedini et al., 2019, Trylinski and Schweisguth, 2019, Wu et al., 2019, Xu et al., 2019, Das et al., 2018, Garrido-Jimenez et al., 2018, Hassan et al., 2018, Medina, 2018, Richardson and Portela, 2018, Spinner et al., 2018, Toret et al., 2018, Tsai et al., 2018, Amourda and Saunders, 2017, Banisch et al., 2017, Chung et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Jang et al., 2017, Kannan et al., 2017, Lu et al., 2017, Nainu et al., 2017, Nakamura et al., 2017, Park et al., 2017, Transgenic RNAi Project members, 2017-, Winfree et al., 2017, Zheng et al., 2017, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Cervantes-Sandoval et al., 2016, Kuleesha et al., 2016, Lee and Schwarz, 2016, Levinson and Cagan, 2016, Ma et al., 2016, Roman-Fernandez and Bryant, 2016, Biersmith et al., 2015, Chen et al., 2015, Eikenes et al., 2015, Enomoto et al., 2015, Enomoto et al., 2015, Felix et al., 2015, Feng et al., 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Luo et al., 2015, Martín-Bermudo et al., 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Pearce et al., 2015, Petsakou et al., 2015, Rodal et al., 2015, Schreij et al., 2015, Song et al., 2015, Sundaram, 2015, Van Bortle et al., 2015, Verboon and Parkhurst, 2015, Vlisidou and Wood, 2015, Yuan et al., 2015, Abe et al., 2014, Abreu-Blanco et al., 2014, Bagley et al., 2014, Cai et al., 2014, Fernández et al., 2014, Goergen et al., 2014, Iordanou et al., 2014, Lammel et al., 2014, Lu et al., 2014, Morishita et al., 2014, Pereira et al., 2014, Salazar-Jaramillo et al., 2014, Swope et al., 2014, Das et al., 2013, Das et al., 2013, Eguchi et al., 2013, Geisbrecht et al., 2013, Jenkins et al., 2013, Khoo et al., 2013, Kwon et al., 2013, Melzer et al., 2013, Myant et al., 2013, Neisch et al., 2013, Parkhurst, 2013.10.2, Pickering et al., 2013, Pirraglia et al., 2013, Puram and Bonni, 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Vaque et al., 2013, Vaqué et al., 2013, Wan et al., 2013, Wang et al., 2013, Zhang et al., 2013, Zhang et al., 2013, Abmayr and Pavlath, 2012, Baek et al., 2012, Chartier et al., 2012, Duan et al., 2012, Etchegaray et al., 2012, Garcia et al., 2012, Howell et al., 2012, Humphreys et al., 2012, Iyer et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Lu et al., 2012, Marchal et al., 2012, Morris et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Shiratsuchi et al., 2012, Tsubouchi et al., 2012, Wang et al., 2012, Ziegenfuss et al., 2012, Zoller and Schulz, 2012, Brumby et al., 2011, Fauvarque and Williams, 2011, Goossens et al., 2011, Guest et al., 2011, Johnson et al., 2011, Kuzina et al., 2011, Lee and Thomas, 2011, Lee et al., 2011, Mirkovic et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Rohn et al., 2011, Tanaka et al., 2011, Taniguchi et al., 2011, Urbano et al., 2011, Ye et al., 2011, Ashton-Beaucage et al., 2010, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, D'Ambrosio and Vale, 2010, Djiane and Mlodzik, 2010, Elsaesser et al., 2010, Evans et al., 2010, Garlena et al., 2010, Guenin et al., 2010, Jones et al., 2010, Kim et al., 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Quinones et al., 2010, Sánchez-Soriano et al., 2010, Sato et al., 2010, Serio et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Singh et al., 2010, Warner, 2010.9.15, Asano et al., 2009, Bond and Foley, 2009, Frank et al., 2009, Gupta et al., 2009, Hashimoto et al., 2009, Hirano et al., 2009, Kuraishi et al., 2009, Tan et al., 2009, van Impel et al., 2009, Bakal et al., 2008, Geisbrecht et al., 2008, Johnson et al., 2008, Matusek et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Warren-Paquin et al., 2008, Avet-Rochex et al., 2007, Badrinath et al., 2007, Badrinath et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beckett and Baylies, 2007, Beltran et al., 2007, Betson and Settleman, 2007, Bruinsma et al., 2007, Colinet et al., 2007, Conder et al., 2007, Impel et al., 2007, Jovceva et al., 2007, Korolchuk et al., 2007, Li and Baker, 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Patel, 2007, Richardson et al., 2007, Stuart et al., 2007, Taniguchi et al., 2007, Taniguchi et al., 2007, Tountas and Fortini, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Blanke and Jackle, 2006, Chanut, 2006, Hozumi et al., 2006, Kerkhoff, 2006, Lovegrove et al., 2006, Nahm et al., 2006, Pipes et al., 2006, Pirraglia et al., 2006, Polaski et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Vasenkova et al., 2006, Williams et al., 2006, Avet-Rochex et al., 2005, Chen et al., 2005, Couceiro et al., 2005, Fernandes et al., 2005, Go, 2005, Pütz et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Rogers et al., 2003, Zelhof et al., 2003)
                  Rac3
                  (Vaqué et al., 2013)
                  RacA
                  (Harden, 1994.8.2)
                  dRac
                  (Magie et al., 2002)
                  dRac1
                  (Tokusumi et al., 2009, Billuart and Chelly, 2003, Schenck et al., 2003, Stronach and Perrimon, 2002)
                  drac1
                  (Gai et al., 2016)
                  rac
                  (Murakami et al., 2017, Rui et al., 2017, Lin et al., 2015, Ostrowski et al., 2015, Külshammer and Uhlirova, 2013, Zhang et al., 2011, Malartre and Bermudo, 2008, Li and Baker, 2007, Parrish et al., 2007, Pütz et al., 2005, Schejter et al., 2005, Takizawa et al., 2003, Kadam and Reuter, 2001, Schock and Perrimon, 2000)
                  rac-1
                  (Scholz et al., 2019)
                  rac1
                  (Oliveira da Silva et al., 2020, Yoong et al., 2020, Zhang et al., 2020, Cervantes-Sandoval et al., 2016, Dollar et al., 2016, Hamp et al., 2016, Ruan et al., 2016, Kamiyama et al., 2015, Soba et al., 2015, Doherty et al., 2014, Herszterg et al., 2013, Pirraglia et al., 2013, Nagel et al., 2012, Zoller and Schulz, 2012, Cammarato et al., 2011, Haralalka et al., 2011, Kim et al., 2011, Pilgram et al., 2011, Pinal and Pichaud, 2011, Assaker et al., 2010, Elsaesser et al., 2010, Malartre et al., 2010, Gildor et al., 2009, Higuchi et al., 2009, Leiss et al., 2009, Georgiou et al., 2008, Shindo et al., 2008, Jinushi-Nakao et al., 2007, Li and Baker, 2007, Sarkar et al., 2007, Yang and Bashaw, 2006, Hu et al., 2005, Lundstrom et al., 2004, Chihara et al., 2003, Xiao and Ruden, 2003, Boutros et al., 1998, Nolan et al., 1998)
                  Name Synonyms
                  Rac
                  (Fanto and McNeill, 2004)
                  Rac GTPase
                  (Felix et al., 2015, Sailem et al., 2014, Song and Giniger, 2011, Oliva and Sierralta, 2010)
                  Rac1
                  (Jaspers et al., 2012, Cammarato et al., 2011)
                  Secondary FlyBase IDs
                  • FBgn0014012
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (756)