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FB2021_03, released June 15, 2021

Gene: Dmel\Cdc42

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General Information
Symbol
Dmel\Cdc42
Species
D. melanogaster
Name
Cdc42
Annotation Symbol
CG12530
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010341
Gene Model Status
Current
Stock Availability
33 publicly available
Gene Summary
Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dcdc42, DmCDC42

Key Links
Genomic Location
Cytogenetic map
18E1-18E1
Sequence location
X:19,697,091..19,699,938 [+]
Recombination map
1-64
RefSeq locus
NC_004354 REGION:19697091..19699938
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (66 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables GTPase activating protein binding
inferred from physical interaction with FLYBASE:RacGAP84C; FB:FBgn0045843
(Raymond et al., 2001)
enables GTPase activity
inferred from direct assay
(Raymond et al., 2001)
enables protein binding
inferred from physical interaction with FLYBASE:Whamy; FB:FBgn0037750
(Liu et al., 2009)
inferred from physical interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
(Dollar et al., 2016)
inferred from physical interaction with UniProtKB:Q9VXE5
(assigned by UniProt )
(Schneeberger and Raabe, 2003)
inferred from physical interaction with UniProtKB:Q9W1B0
(assigned by UniProt )
(Luo et al., 1997)
enables protein kinase binding
inferred from physical interaction with FLYBASE:mbt; FB:FBgn0025743
(Schneeberger and Raabe, 2003)
inferred from physical interaction with FLYBASE:Pak3; FB:FBgn0044826
(Harden et al., 1996)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (52 terms)
Terms Based on Experimental Evidence (45 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton reorganization
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
involved_in actin filament polymerization
inferred from mutant phenotype
(Eaton et al., 1996)
involved_in axon extension
inferred from genetic interaction with FLYBASE:Frl; FB:FBgn0267795
(Dollar et al., 2016)
involved_in axon guidance
inferred from mutant phenotype
(Fritz and VanBerkum, 2002, Kim et al., 2002)
involved_in branch fusion, open tracheal system
inferred from mutant phenotype
(Wolf et al., 2002)
involved_in branching involved in open tracheal system development
inferred from mutant phenotype
(Jones and Metzstein, 2011)
involved_in cell projection assembly
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Kamiyama and Chiba, 2009, Sanchez-Soriano et al., 2005, Scott et al., 2003, Gao et al., 1999)
involved_in dorsal appendage formation
inferred from mutant phenotype
(Suzanne et al., 2001)
involved_in dorsal closure
inferred from mutant phenotype
(assigned by UniProt )
(Sem et al., 2002)
inferred from mutant phenotype
(Riesgo-Escovar et al., 1996)
involved_in encapsulation of foreign target
inferred from mutant phenotype
(Sampson et al., 2012)
involved_in establishment of neuroblast polarity
inferred from mutant phenotype
(Atwood et al., 2007)
involved_in exocyst localization
inferred from mutant phenotype
(Jones et al., 2014)
involved_in hemocyte migration
inferred from mutant phenotype
(Stramer et al., 2005)
involved_in imaginal disc-derived wing hair outgrowth
inferred from mutant phenotype
(Eaton et al., 1996)
involved_in maintenance of cell polarity
inferred from mutant phenotype
(Stramer et al., 2005)
involved_in maintenance of protein location
inferred from mutant phenotype
(assigned by UniProt )
(Schneeberger and Raabe, 2003)
involved_in melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Dorsten et al., 2007)
involved_in nephrocyte filtration
inferred from mutant phenotype
(Zhang et al., 2013)
involved_in neuromuscular synaptic transmission
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
(Pilgram et al., 2011)
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
(Pilgram et al., 2011)
involved_in neuron projection development
inferred from mutant phenotype
(Allen et al., 2000)
involved_in neuron projection morphogenesis
inferred from mutant phenotype
(Petsakou et al., 2015)
involved_in ommatidial rotation
inferred from genetic interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
(Dollar et al., 2016)
involved_in phagocytosis
inferred from mutant phenotype
(Sampson et al., 2012)
involved_in positive regulation of filopodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010, Wolf et al., 2002)
involved_in positive regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
involved_in positive regulation of lamellipodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010)
involved_in positive regulation of protein kinase activity
inferred from mutant phenotype
(assigned by UniProt )
(Schneeberger and Raabe, 2003)
involved_in positive regulation of wound healing
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
involved_in protein localization to plasma membrane
inferred from mutant phenotype
(Jones et al., 2014)
involved_in regulation of actin filament polymerization
inferred from direct assay
(Rodal et al., 2008)
inferred from mutant phenotype
(Rotkopf et al., 2011)
involved_in regulation of axonogenesis
inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712
(Ng and Luo, 2004)
involved_in regulation of cell shape
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in regulation of neurotransmitter secretion
inferred from mutant phenotype
(Jantrapirom et al., 2019)
involved_in regulation of synaptic assembly at neuromuscular junction
inferred from direct assay
(Nahm et al., 2010)
inferred from mutant phenotype
(Rodal et al., 2008)
involved_in response to wounding
inferred from mutant phenotype
(Nakamura et al., 2017)
involved_in Rho protein signal transduction
inferred from genetic interaction with FLYBASE:Zir; FB:FBgn0031216
(Sampson et al., 2012)
involved_in sensory perception of touch
inferred from mutant phenotype
(Tsubouchi et al., 2012)
involved_in spermatid development
inferred from mutant phenotype
(Rotkopf et al., 2011)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
involved_in vesicle-mediated transport
inferred from mutant phenotype
(Jones et al., 2014)
involved_in wound healing
inferred from mutant phenotype
(Abreu-Blanco et al., 2012, Wood et al., 2002)
NOT involved_in dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
traceable author statement
(Johnstone and Lasko, 2001)
involved_in axonogenesis
traceable author statement
(Gao et al., 1999)
involved_in Cdc42 protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cell migration
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cell projection assembly
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cellularization
traceable author statement
(Mazumdar and Mazumdar, 2002)
involved_in dorsal closure
traceable author statement
(Harden, 2002, Noselli and Agnes, 1999)
involved_in endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in oogenesis
traceable author statement
(Harden, 2002)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Fletcher et al., 2012)
located_in axon
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in cell cortex
inferred from direct assay
(Leibfried et al., 2013)
located_in cytoplasm
inferred from direct assay
(Leibfried et al., 2013, Kamiyama and Chiba, 2009)
located_in growth cone
inferred from direct assay
(Kim et al., 2002)
located_in lamellipodium
inferred from direct assay
(assigned by UniProt )
(Shim et al., 2010)
located_in nucleus
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in rhabdomere
inferred from mutant phenotype
(Zelhof and Hardy, 2004)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (P40793)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions (PubMed:12490550). Together with mbt and Frl, regulates photoreceptor cell morphogenesis (PubMed:12490550, PubMed:26801180). Together with Frl, has a role in the neuronal development of mushroom bodies (PubMed:26801180).
(UniProt, P40793)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cdc42 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.40

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cdc42-RA
FBtr0074751
NM_078690
1392
191
Cdc42-RC
FBtr0309214
NM_001258833
2078
191
Cdc42-RD
FBtr0309215
NM_001258834
2005
191
Additional Transcript Data and Comments
Reported size (kB)

2.3 (northern blot)

(Luo et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cdc42-PA
FBpp0074520
21.4
191
7.21
NP_523414
AAF49007
Cdc42-PC
FBpp0301153
21.4
191
7.21
NP_001245762
AFH07474
Cdc42-PD
FBpp0301154
21.4
191
7.21
NP_001245763
AFH07475
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

191 aa isoforms: Cdc42-PA, Cdc42-PC, Cdc42-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

191 (aa)

(Luo et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).

(UniProt, P40793)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc42 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Sasamura et al., 1997)
presumptive embryonic/larval central nervous system
(Luo et al., 1994)
embryonic/larval digestive system
(Luo et al., 1994)
embryonic stage -- adult stage
(Sasamura et al., 1997, Luo et al., 1994)
blastoderm stage
organism | ubiquitous
(Luo et al., 1994)
embryonic stage 10 -- 12
somatic mesoderm
(Luo et al., 1994)
Additional Descriptive Data

Cdc42 is expressed in all developmental stages. It is expressed ubiquitously in embryos.

(Sasamura et al., 1997)

Cdc42 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.

(Luo et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Fletcher et al., 2012)
located_in axon
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in cell cortex
inferred from direct assay
(Leibfried et al., 2013)
located_in cytoplasm
inferred from direct assay
(Leibfried et al., 2013, Kamiyama and Chiba, 2009)
located_in growth cone
inferred from direct assay
(Kim et al., 2002)
located_in lamellipodium
inferred from direct assay
(assigned by UniProt )
(Shim et al., 2010)
located_in nucleus
inferred from direct assay
(Kamiyama and Chiba, 2009)
located_in plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in rhabdomere
inferred from mutant phenotype
(Zelhof and Hardy, 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc42 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 52 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdc42
Transgenic constructs containing regulatory region of Cdc42
Aberrations (Deficiencies and Duplications) ( 6 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4198Y
lethal, with Scer\GAL4238Y
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4hs.PB
lethal | female, with Scer\GAL4306
lethal | recessive
lethal | somatic clone
lethal - all die before end of larval stage, with Scer\GAL4109-30
lethal - all die before end of larval stage, with Scer\GAL4109-39
lethal - all die before end of larval stage, with Scer\GAL4109-53
lethal - all die before end of larval stage, with Scer\GAL4109-69
lethal - all die before end of larval stage, with Scer\GAL4109-79
lethal - all die before end of larval stage, with Scer\GAL4sca-109-68
lethal - all die before end of pupal stage, with Scer\GAL4how-24B
lethal - all die during embryonic stage, with Scer\GAL469B
lethal - all die during embryonic stage, with Scer\GAL4en-e16E
lethal - all die during embryonic stage, with Scer\GAL4how-24B
lethal - all die during embryonic stage | maternal effect | partially (with Cdc423)
lethal - all die during embryonic stage | maternal effect | partially (with Cdc424)
lethal - all die during embryonic stage | maternal effect | partially (with Cdc426)
lethal - all die during embryonic stage | non-rescuable maternal effect
partially lethal, with Scer\GAL4elav.PLu
partially lethal - majority die, with Scer\GAL4212
viable
viable, with Scer\GAL4212
viable, with Scer\GAL4306
viable, with Scer\GAL4458
viable, with Scer\GAL4hs.PB
viable | heat sensitive
Sterility
Allele
male sterile, with Scer\GAL4A3.eya
Other Phenotypes
Allele
abnormal cell migration | embryonic stage, with Scer\GAL4Pxn.PS
abnormal cell polarity
abnormal cell polarity, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
abnormal cell polarity, with Scer\GAL4wor.PA
abnormal cell polarity | maternal effect (with Cdc423)
abnormal cell polarity | maternal effect (with Cdc426)
abnormal immune response | larval stage
abnormal memory | adult stage, with Scer\GAL4elav.PU
abnormal memory | adult stage, with Scer\GAL4ey-OK107
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4C57
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4eve.RN2
abnormal neuroanatomy, with Scer\GAL4Mhc.Switch.PO
abnormal neuroanatomy, with Scer\GAL4Mz317
abnormal neuroanatomy, with Scer\GAL4P0.5.Pdf
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4ftz.ng
abnormal neuroanatomy | larval stage, with Scer\GAL41003.3
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage
abnormal neurophysiology
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Mhc.PU
abnormal planar polarity
abnormal planar polarity | somatic clone
abnormal size | third instar larval stage
abnormal touch response | larval stage, with Scer\GAL41003.3
abnormal wound healing, with Scer\GAL4en-e16E
abnormal wound healing | embryonic stage (with Cdc424)
abnormal wound healing | embryonic stage (with Cdc426)
chemical resistant, with Scer\GAL4NP1514
chemical sensitive, with Scer\GAL4NP1514
decreased cell number | adult stage, with Scer\GAL4sev.EP
decreased cell size | somatic clone
some die during embryonic stage, with Scer\GAL469B
some die during embryonic stage, with Scer\GAL4en-e16E
some die during embryonic stage, with Scer\GAL4how-24B
some die during embryonic stage | non-rescuable maternal effect
some die during embryonic stage | partially (with Cdc423)
some die during embryonic stage | partially (with Cdc424)
some die during embryonic stage | partially (with Cdc426)
some die during larval stage, with Scer\GAL4109-30
some die during larval stage, with Scer\GAL4109-39
some die during larval stage, with Scer\GAL4109-53
some die during larval stage, with Scer\GAL4109-69
some die during larval stage, with Scer\GAL4109-79
some die during larval stage, with Scer\GAL4sca-109-68
some die during pupal stage, with Scer\GAL4how-24B
visible
visible, with Scer\GAL4en-e16E
visible (with Cdc421)
visible (with Cdc425)
visible | adult stage, with Scer\GAL4eya.enh1+E+2
visible | somatic clone
wild-type
Phenotype manifest in
Allele
A1-7 ventral longitudinal muscle | third instar larval stage, with Scer\GAL4Mhc.PU
abdominal posterior fascicle neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
aCC neuron, with Scer\GAL4eve.RN2
aCC neuron & dendrite, with Scer\GAL4eve.RN2
actin filament, with Scer\GAL4T155
actin filament & rhabdomere | somatic clone
actin filament | germline clone | maternal effect (with Cdc424)
actin filament | germline clone | maternal effect (with Cdc426)
adult antennal lobe commissure, with Scer\GAL4SG18.1
adult heart, with Scer\GAL4how-24B
adult heart, with Scer\GAL4tin.CΔ4
adult mushroom body alpha-lobe | adult stage
adult mushroom body beta-lobe | adult stage
antenna & glial cell, with Scer\GAL4Mz317
antenna & sensory neuron, with Scer\GAL4Mz317
antennal lobe glomerulus, with Scer\GAL4SG18.1
anterior crossvein | ectopic
anterior crossvein | ectopic (with Cdc421)
anterior crossvein | ectopic (with Cdc425)
anterior-posterior compartment boundary of the wing disc, with Scer\GAL4ptc-559.1
axon
axon | adult stage
bouton
bouton, with Scer\GAL4C57
bouton, with Scer\GAL4Mhc.Switch.PO
cardiac myofibril, with Scer\GAL4how-24B
cardiac myofibril, with Scer\GAL4tin.CΔ4
cardial cell, with Scer\GAL4how-24B
cardial cell, with Scer\GAL4tin.CΔ4
commissure | embryonic stage 16, with Scer\GAL4ftz.ng
crossvein | cell non-autonomous | ectopic, with Scer\GAL4Bx-MS1096
crossvein | ectopic
crossvein | increased number, with Scer\GAL4en-e16E
dendrite
dendrite | dorsal | embryonic stage, with Scer\GAL460
dendrite | ectopic
dendritic spine
dMP2 neuron, with Scer\GAL4ftz.ng
dorsal abdominal cluster
dorsal appendage, with Scer\GAL4CY2
dorsal multidendritic neuron & dendrite & embryo, with Scer\GAL460
embryo, with Scer\GAL4twi.PU
embryo | anterior | maternal effect (with Cdc423)
embryo | anterior | maternal effect (with Cdc426)
embryo | dorsal closure stage, with Scer\GAL4en-e16E
embryo | dorsal closure stage | heat sensitive, with Scer\GAL4hs.PB
embryo | dorsal closure stage | maternal effect (with Cdc423)
embryo | dorsal closure stage | maternal effect (with Cdc426)
embryo | maternal effect (with Cdc423)
embryo | maternal effect (with Cdc424)
embryo | maternal effect (with Cdc426)
embryonic/first instar larval cuticle, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle, with Scer\GAL4twi.PG
embryonic/first instar larval cuticle | dorsal, with Scer\GAL469B
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle | heat sensitive, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | maternal effect | ventral (with Cdc423)
embryonic/first instar larval cuticle | maternal effect | ventral (with Cdc426)
embryonic/larval anterior midgut, with Scer\GAL4NP3392
embryonic/larval cuticle | embryonic stage | maternal effect, with Scer\GAL4da.G32
embryonic/larval dorsal trunk, with Scer\GAL4hs.2sev
embryonic/larval lateral trunk, with Scer\GAL4btl.PS
embryonic/larval midgut | embryonic stage, with Scer\GAL448Y
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval pericardial cell, with Scer\GAL4Ugt36A1.PK
embryonic/larval somatic muscle, with Scer\GAL4twi.PG
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic epidermis, with Scer\GAL4hs.PB
embryonic epidermis | dorsal, with Scer\GAL4en-e16E
embryonic epidermis | maternal effect | ventral (with Cdc423)
embryonic epidermis | maternal effect | ventral (with Cdc426)
embryonic hemocyte, with Scer\GAL4Pxn.PS
embryonic hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic hemocyte (with Cdc423)
embryonic hemocyte (with Cdc426)
embryonic hemocyte & leading edge, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic proventriculus
embryonic proventriculus, with Scer\GAL4retn-GAL4
epithelium, with Scer\GAL4NP1624
eye
eye, with Scer\GAL4eya.enh1+E+2
eye (with Cdc421)
eye (with Cdc425)
eye disc, with Scer\GAL4ey.PH
eye photoreceptor cell, with Scer\GAL4sev.EP
eye photoreceptor cell | somatic clone
female germline cyst, with Scer\GAL4NP1624
follicle cell, with Scer\GAL4Act5C.PP
follicle cell | somatic clone
ganglionic branch primordium
giant axon
giant fiber neuron, with Scer\GAL4shakB.lethal.4.1
glomerulus | ectopic, with Scer\GAL4SG18.1
growth cone, with Scer\GAL4elav.PLu
growth cone, with Scer\GAL4elav-C155
head cyst cell, with Scer\GAL4T155
interommatidial bristle
interommatidial bristle (with Cdc421)
interommatidial bristle (with Cdc425)
larval abdominal intersegmental nerve
larval abdominal intersegmental nerve, with Scer\GAL4elav.PLu
larval abdominal segmental nerve, with Scer\GAL4elav.PLu
larval abdominal segmental nerve, with Scer\GAL4elav-C155
larval dorsal multidendritic neuron | embryonic stage, with Scer\GAL460
larval dorsal multidendritic neuron ddaA | larval stage, with Scer\GAL41003.3
larval longitudinal connective | maternal effect (with Cdc423)
larval longitudinal connective | maternal effect (with Cdc426)
larval ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4ftz.ng
macrochaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
macrophage
macrophage, with Scer\GAL4Col4a1-A109.1F2.P
macrophage, with Scer\GAL4da.G32
macrophage, with Scer\GAL4gcm-rA87.P
medial triple row, with Scer\GAL4Bx-MS1096
mesothoracic leg disc, with Scer\GAL4dpp.blk1
mesothoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
metathoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
microchaeta, with Scer\GAL4ptc-559.1
microchaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
microchaeta & wing, with Scer\GAL4ptc-559.1
motor neuron, with Scer\GAL4elav.PLu
motor neuron, with Scer\GAL4elav-C155
muscle attachment site, with Scer\GAL4twi.PG
myotube, with Scer\GAL4twi.PG
neurite
neuroblast | embryonic stage, with Scer\GAL4wor.PA
neuroblast | third instar larval stage
neuromuscular junction
neuromuscular junction, with Scer\GAL4C57
neuromuscular junction, with Scer\GAL4Mhc.Switch.PO
neuron, with Scer\GAL4elav.PLu
neuron, with Scer\GAL4elav-C155
NMJ bouton | third instar larval stage
nurse cell
nurse cell, with Scer\GAL4VP16.osk
nurse cell & actin filament | germ-line clone | maternal effect
nurse cell ring canal | germline clone | maternal effect (with Cdc424)
nurse cell ring canal | germline clone | maternal effect (with Cdc426)
ommatidium
ommatidium, with Scer\GAL4sev.EP
ommatidium (with Cdc421)
ommatidium (with Cdc425)
ommatidium | somatic clone
oocyte | germline clone
oocyte | germline clone | maternal effect
pCC neuron, with Scer\GAL4ftz.ng
photoreceptor
pigment cell
plasma membrane bounded cell projection | embryonic stage, with Scer\GAL4Pxn.PS
presumptive embryonic/larval central nervous system | maternal effect (with Cdc423)
presumptive embryonic/larval central nervous system | maternal effect (with Cdc426)
presumptive embryonic/larval peripheral nervous system | dorsal, with Scer\GAL460
presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS
proventriculus inner layer primordium
proventriculus inner layer primordium, with Scer\GAL4retn-GAL4
proventriculus intermediate layer primordium
proventriculus intermediate layer primordium, with Scer\GAL4retn-GAL4
retina | somatic clone
rhabdomere
RP2 motor neuron | ectopic, with Scer\GAL4eve.RN2
RP2 neuron & cell body, with Scer\GAL4eve.RN2
RP2 neuron & dendrite, with Scer\GAL4eve.RN2
RP2 neuron & neurite, with Scer\GAL4eve.RN2
seminal vesicle, with Scer\GAL4A3.eya
sensory dendrite | larval stage, with Scer\GAL41003.3
s-LNv Pdf neuron, with Scer\GAL4P0.5.Pdf
somatic muscle, with Scer\GAL4how-24B
spermatid cyst, with Scer\GAL4A3.eya
spermatid cyst, with Scer\GAL4T155
tergal depressor of trochanter muscle motor neuron & dendrite, with Scer\GAL4shakB.lethal.4.1
terminal tracheal cell | somatic clone
vertical system neuron
vMP2 neuron, with Scer\GAL4ftz.ng
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4ptc-559.1
wing (with Cdc421)
wing (with Cdc425)
wing hair, with Scer\GAL4Bx-MS1096
wing hair | ectopic, with Scer\GAL4Bx-MS1096
wing hair | increased number, with Scer\GAL4en-e16E
wing hair | somatic clone | increased number
wing margin, with Scer\GAL4Bx-MS1096
wing margin bristle, with Scer\GAL4Bx-MS1096
wing vein | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDC42
14 of 15
Yes
Yes
0  
Hsap\RHOQ
4 of 15
No
Yes
Hsap\RAC1
3 of 15
No
No
3  
Hsap\RAC2
3 of 15
No
No
1  
Hsap\RAC3
3 of 15
No
No
Hsap\RHOG
3 of 15
No
No
Hsap\RHOJ
3 of 15
No
Yes
Hsap\RHOU
3 of 15
No
No
Hsap\RHOF
2 of 15
No
Yes
Hsap\RHOV
2 of 15
No
No
Hsap\RHOA
1 of 15
No
No
4  
Hsap\RHOB
1 of 15
No
No
1  
Hsap\RHOBTB1
1 of 15
No
No
Hsap\RHOBTB2
1 of 15
No
No
1  
Hsap\RHOBTB3
1 of 15
No
No
Hsap\RHOC
1 of 15
No
No
1  
Hsap\RHOD
1 of 15
No
No
Hsap\RHOH
1 of 15
No
No
Hsap\RND1
1 of 15
No
Yes
Hsap\RND2
1 of 15
No
Yes
Hsap\RND3
1 of 15
No
Yes
Hsap\SLC2A3
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdc42
13 of 15
Yes
Yes
Mmus\Rhoq
4 of 15
No
Yes
Mmus\Rac1
3 of 15
No
No
Mmus\Rac2
3 of 15
No
No
Mmus\Rac3
3 of 15
No
No
Mmus\Rhog
3 of 15
No
No
Mmus\Rhoj
3 of 15
No
Yes
Mmus\Rhou
3 of 15
No
No
Mmus\Rhof
2 of 15
No
Yes
Mmus\Rhoh
2 of 15
No
No
Mmus\4930544G11Rik
1 of 15
No
No
Mmus\Rhoa
1 of 15
No
No
Mmus\Rhob
1 of 15
No
No
Mmus\Rhobtb1
1 of 15
No
No
Mmus\Rhobtb2
1 of 15
No
No
Mmus\Rhobtb3
1 of 15
No
No
Mmus\Rhoc
1 of 15
No
No
Mmus\Rhod
1 of 15
No
No
Mmus\Rhov
1 of 15
No
No
Mmus\Rnd1
1 of 15
No
Yes
Mmus\Rnd2
1 of 15
No
Yes
Mmus\Rnd3
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
Rnor\Cdc42
12 of 13
Yes
Yes
Rnor\Rhoq
4 of 13
No
Yes
Rnor\Rac1
3 of 13
No
No
Rnor\Rac2
3 of 13
No
No
Rnor\Rhog
3 of 13
No
No
Rnor\Rhoj
3 of 13
No
Yes
Rnor\Rac3
2 of 13
No
Yes
Rnor\Rhof
2 of 13
No
Yes
Rnor\Rhoh
2 of 13
No
No
Rnor\Rhou
2 of 13
No
Yes
Rnor\Rhov
2 of 13
No
No
Rnor\Rhoa
1 of 13
No
No
Rnor\Rhob
1 of 13
No
No
Rnor\Rhobtb1
1 of 13
No
No
Rnor\Rhobtb2
1 of 13
No
No
Rnor\Rhobtb3
1 of 13
No
No
Rnor\Rhoc
1 of 13
No
No
Rnor\Rhod
1 of 13
No
No
Rnor\Rnd2
1 of 13
No
Yes
Rnor\Rnd3
1 of 13
No
Yes
Rnor\RSA-14-44
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\cdc42
11 of 12
Yes
Yes
Xtro\rhoq
4 of 12
No
Yes
Xtro\rac1
3 of 12
No
No
Xtro\rac2
3 of 12
No
No
Xtro\rhoj
3 of 12
No
Yes
Xtro\rhou
3 of 12
No
No
Xtro\rac3
2 of 12
No
Yes
Xtro\rhof
2 of 12
No
Yes
Xtro\rhog
2 of 12
No
No
Xtro\rhog
2 of 12
No
Yes
Xtro\rhov
2 of 12
No
No
Xtro\rhoa.2
1 of 12
No
No
Xtro\rhoa
1 of 12
No
No
Xtro\rhobtb1
1 of 12
No
No
Xtro\rhobtb2
1 of 12
No
No
Xtro\rhobtb3
1 of 12
No
Yes
Xtro\rhob
1 of 12
No
No
Xtro\rhoc
1 of 12
No
No
Xtro\rhoh
1 of 12
No
Yes
Xtro\rnd1
1 of 12
No
Yes
Xtro\rnd3
1 of 12
No
Yes
Danio rerio (Zebrafish) (41)
Drer\cdc42
13 of 15
Yes
Yes
Drer\cdc42l
10 of 15
No
Yes
Drer\cdc42l2
6 of 15
No
Yes
Drer\rhoq
4 of 15
No
Yes
Drer\rac1a
3 of 15
No
No
Drer\rac1b
3 of 15
No
No
Drer\rac1l
3 of 15
No
No
Drer\rac3b
3 of 15
No
No
Drer\rhoga
3 of 15
No
No
Drer\rhogb
3 of 15
No
No
Drer\rhogc
3 of 15
No
No
Drer\rhogd
3 of 15
No
No
Drer\rhoj
3 of 15
No
Yes
Drer\rhoua
3 of 15
No
No
Drer\rhoub
3 of 15
No
No
Drer\rhov
3 of 15
No
No
Drer\si:ch211-133l11.10
3 of 15
No
No
Drer\LOC100537765
2 of 15
No
No
Drer\rac2
2 of 15
No
No
Drer\rac3a
2 of 15
No
No
Drer\rhof
2 of 15
No
Yes
Drer\rhoh
2 of 15
No
No
Drer\LOC100331257
1 of 15
No
No
Drer\rhoaa
1 of 15
No
No
Drer\rhoab
1 of 15
No
No
Drer\rhoac
1 of 15
No
No
Drer\rhobtb1
1 of 15
No
No
Drer\rhobtb2a
1 of 15
No
No
Drer\rhobtb2b
1 of 15
No
No
Drer\rhobtb4
1 of 15
No
No
Drer\rhoca
1 of 15
No
No
Drer\rhocb
1 of 15
No
No
Drer\rnd1a
1 of 15
No
Yes
Drer\rnd1b
1 of 15
No
Yes
Drer\rnd2
1 of 15
No
Yes
Drer\rnd3a
1 of 15
No
Yes
Drer\rnd3b
1 of 15
No
Yes
Drer\si:ch211-1f22.1
1 of 15
No
No
Drer\si:ch211-1f22.2
1 of 15
No
No
Drer\si:dkey-6b12.5
1 of 15
No
No
Drer\wu:fb95b01
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\cdc-42
12 of 15
Yes
Yes
Cele\ced-10
3 of 15
No
No
Cele\chw-1
3 of 15
No
No
Cele\crp-1
3 of 15
No
Yes
Cele\mig-2
3 of 15
No
No
Cele\rac-2
3 of 15
No
No
Cele\rho-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\ARAC1
6 of 9
Yes
No
Atha\ARAC5
6 of 9
Yes
No
Atha\ARAC9
6 of 9
Yes
No
Atha\RAC2
6 of 9
Yes
No
Atha\RAC3
6 of 9
Yes
No
Atha\RAC6
6 of 9
Yes
No
Atha\ROP1
6 of 9
Yes
No
Atha\ROP2
6 of 9
Yes
No
Atha\ROP9
6 of 9
Yes
Yes
Atha\RAC10
5 of 9
No
No
Atha\ROP10
5 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\CDC42
13 of 15
Yes
Yes
1  
Scer\RHO1
1 of 15
No
No
Scer\RHO2
1 of 15
No
No
Scer\RHO3
1 of 15
No
No
Scer\RHO4
1 of 15
No
No
Scer\RHO5
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cdc42
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FXQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008375
Drosophila simulans
Dsim\GD17456
Drosophila sechellia
Dsec\GM22983
Drosophila erecta
Dere\GG19248
Drosophila yakuba
Dyak\GE15867
Drosophila ananassae
Dana\GF20423
Drosophila pseudoobscura pseudoobscura
Dpse\GA11680
Drosophila persimilis
Dper\GL18265
Drosophila willistoni
Dwil\GK17312
Drosophila virilis
Dvir\GJ15962
Drosophila mojavensis
Dmoj\GI11109
Drosophila grimshawi
Dgri\GH12491
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BEP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009155
Glossina morsitans
Tsetse fly
Gmor\GMOY003464
Mayetiola destructor
Hessian fly
Mdes\Mdes006638
Aedes aegypti
Yellow fever mosquito
Aaeg\Cdc42
Anopheles darlingi
American malaria mosquito
Adar\ADAC006233
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D88 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006475
Bombyx mori
Silkmoth
Bmor\BGIBMGA007110
Bombyx mori
Silkmoth
Bmor\BGIBMGA012295
Danaus plexippus
Monarch butterfly
Dple\DPOGS210795-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203397-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210992-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016632
Heliconius melpomene
Postman butterfly
Hmel\HMEL025024
Heliconius melpomene
Postman butterfly
Hmel\HMEL007742
Apis florea
Little honeybee
Aflo\2477932532
Apis florea
Little honeybee
Aflo\2728460068
Apis florea
Little honeybee
Aflo\2154241108
Apis florea
Little honeybee
Aflo\2557575572
Apis mellifera
Western honey bee
Amel\GB45558
Apis mellifera
Western honey bee
Amel\GB45657
Apis mellifera
Western honey bee
Amel\GB55933
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12709
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15218
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17804
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18936
Bombus terrestris
Buff-tailed bumblebee
Bter\15216567
Bombus terrestris
Buff-tailed bumblebee
Bter\15211351
Bombus terrestris
Buff-tailed bumblebee
Bter\15208628
Bombus terrestris
Buff-tailed bumblebee
Bter\15216192
Linepithema humile
Argentine ant
Lhum\LH23269
Linepithema humile
Argentine ant
Lhum\LH15884
Linepithema humile
Argentine ant
Lhum\LH20173
Linepithema humile
Argentine ant
Lhum\LH17483
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0011f3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003131
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002966
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0018bc
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000948
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021442
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019951
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009052
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06840
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10346
Tribolium castaneum
Red flour beetle
Tcas\TC013187
Tribolium castaneum
Red flour beetle
Tcas\Rac1
Tribolium castaneum
Red flour beetle
Tcas\TC000961
Pediculus humanus
Human body louse
Phum\PHUM344070
Pediculus humanus
Human body louse
Phum\PHUM376850
Pediculus humanus
Human body louse
Phum\PHUM424410
Rhodnius prolixus
Kissing bug
Rpro\RPRC003442
Rhodnius prolixus
Kissing bug
Rpro\RPRC008853
Rhodnius prolixus
Kissing bug
Rpro\RPRC013286
Cimex lectularius
Bed bug
Clec\CLEC008884
Cimex lectularius
Bed bug
Clec\CLEC011807
Cimex lectularius
Bed bug
Clec\CLEC011605
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009526
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000070
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004385
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07397
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13055
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01188
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CS8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011334
Ixodes scapularis
Black-legged tick
Isca\ISCW016255
Ixodes scapularis
Black-legged tick
Isca\ISCW011749
Ixodes scapularis
Black-legged tick
Isca\ISCW003614
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77036.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61734.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68170.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g01600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g04000
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01520
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299952
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307551
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306746
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdc42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Racl1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rhop3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rac
Ciona intestinalis
Vase tunicate
Cint\LOC448958
Ciona intestinalis
Vase tunicate
Cint\LOC445702
Ciona intestinalis
Vase tunicate
Cint\LOC448957
Ciona intestinalis
Vase tunicate
Cint\rac3a
Ciona intestinalis
Vase tunicate
Cint\rac2
Gallus gallus
Domestic chicken
Ggal\RAC2
Gallus gallus
Domestic chicken
Ggal\CDC42
Gallus gallus
Domestic chicken
Ggal\RAC3
Gallus gallus
Domestic chicken
Ggal\RHOG
Gallus gallus
Domestic chicken
Ggal\RHOJ
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026995
Gallus gallus
Domestic chicken
Ggal\RAC1
Gallus gallus
Domestic chicken
Ggal\RHOQ
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Mtl
6 of 10
Rac1
6 of 10
Rac2
6 of 10
Rho1
3 of 10
RhoBTB
3 of 10
RhoU
3 of 10
Miro
2 of 10
RhoL
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Cdc421
model of  cancer
CEA with Ras85DV12.UAS
(Pagliarini and Xu, 2003)
Cdc42JF02855
model of  kidney disease
CEA
(Zhang et al., 2013)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CDC42; cell division cycle 42
14 of 15
116952
     
    RHOQ; ras homolog family member Q
    4 of 15
    605857
        RAC1; Rac family small GTPase 1
        3 of 15
        602048
         
        RAC2; Rac family small GTPase 2
        3 of 15
        602049
         
        RAC3; Rac family small GTPase 3
        3 of 15
        602050
          RHOG; ras homolog family member G
          3 of 15
          179505
              RHOJ; ras homolog family member J
              3 of 15
              607653
                  RHOU; ras homolog family member U
                  3 of 15
                  606366
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      esyN Network Diagram
                      Show neighbor-neighbor interactions:
                      Select Layout:
                      Legend:
                      Protein
                      RNA
                      Selected Interactor(s)
                      Interactions Browser
                      View in Interactions Browser
                      Please see the Physical Interaction reports below for full details
                      protein-protein
                      Physical Interaction
                      Assay
                      References
                      Cdc42 - Abi
                      pull down, western blot
                      (Fricke et al., 2009)
                      Cdc42 - CG12299
                      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                      (Rhee et al., 2014)
                      Cdc42 - Cip4
                      pull down, autoradiography, anti tag western blot, two hybrid, western blot
                      (Brinkmann et al., 2016, Nahm et al., 2010, Fricke et al., 2009, Leibfried et al., 2008)
                      Cdc42 - Frl
                      pull down, autoradiography
                      (Dollar et al., 2016)
                      Cdc42 - GEFmeso
                      pull down, autoradiography, enzymatic study
                      (Sundaram, 2015, Blanke and Jackle, 2006)
                      Cdc42 - Pak
                      pull down, autoradiography, western blot
                      (Nahm et al., 2006, Harden et al., 1996)
                      Cdc42 - Pak3
                      anti tag coimmunoprecipitation, western blot
                      (Mentzel and Raabe, 2005)
                      Cdc42 - RhoGAP100F
                      enzymatic study, fluorescence technology, pull down, anti tag western blot
                      (Spinner et al., 2018)
                      Cdc42 - RhoGAP18B
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Ojelade et al., 2015)
                      Cdc42 - RhoGAP92B
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Neisch et al., 2013)
                      Cdc42 - RhoGEF2
                      pull down, autoradiography
                      (Nakamura et al., 2017)
                      Cdc42 - SCAR
                      pull down, western blot
                      (Fricke et al., 2009)
                      Cdc42 - WASp
                      enzymatic study, pull down, autoradiography, fluorescent resonance energy transfer, fluorescence microscopy, anti tag western blot, western blot
                      (Sharifai et al., 2014, Nahm et al., 2010, Fricke et al., 2009, Liu et al., 2009, Rodal et al., 2008)
                      Cdc42 - Whamy
                      pull down, anti tag western blot, autoradiography
                      (Brinkmann et al., 2016, Liu et al., 2009)
                      Cdc42 - aPKC
                      anti bait coimmunoprecipitation, western blot
                      (Leibfried et al., 2013)
                      Cdc42 - dsx
                      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                      (Rhee et al., 2014)
                      Cdc42 - gek
                      pull down, autoradiography, two hybrid
                      (Luo et al., 1997)
                      Cdc42 - mbt
                      anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
                      (Melzer et al., 2013, Schneeberger and Raabe, 2003)
                      Cdc42 - nwk
                      enzymatic study
                      (Rodal et al., 2008)
                      Cdc42 - par-6
                      nuclear magnetic resonance, pull down, autoradiography, western blot, molecular weight estimation by coomasie staining
                      (Nunes de Almeida et al., 2019, Atwood et al., 2007, Hutterer et al., 2004, Peterson et al., 2004)
                      Cdc42 - pbl
                      pull down, autoradiography, anti tag western blot
                      (Nakamura et al., 2017, Rosa et al., 2015)
                      Cdc42 - slpr
                      pull down, autoradiography, anti tag coimmunoprecipitation, western blot
                      (Garlena et al., 2010, Neisch et al., 2010)
                      Cdc42 - smt3
                      anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, western blot
                      (Handu et al., 2015)
                      RNA-protein
                      Physical Interaction
                      Assay
                      References
                      Cdc42 - fne
                      anti tag coimmunoprecipitation, quantitative reverse transcription pcr
                      (Alizzi et al., 2020)
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      esyN Network Key:
                      Suppression
                      Enhancement
                      View in Interactions Browser
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Cdc42
                      suppressible
                      Ack
                      (Sem et al., 2002)
                      Cdc42
                      enhanceable
                      bchs
                      (Raymond et al., 2004)
                      Cdc42
                      enhanceable
                      bol
                      (Zhu et al., 2005)
                      Cdc42
                      enhanceable
                      C3G
                      (Raymond et al., 2004)
                      Cdc42
                      enhanceable
                      CG7231
                      (Zhu et al., 2005)
                      Cdc42
                      suppressible
                      CG10082
                      (Zhu et al., 2005)
                      Cdc42
                      suppressible
                      chic
                      (Fritz and VanBerkum, 2002)
                      Cdc42
                      enhanceable
                      Cip4
                      (Nahm et al., 2010)
                      Cdc42
                      enhanceable
                      Cip4|WASp
                      (Nahm et al., 2010)
                      Cdc42
                      enhanceable
                      dco
                      (Zhu et al., 2005)
                      Cdc42
                      enhanceable
                      Eip78C
                      (Zhu et al., 2005)
                      Cdc42
                      suppressible
                      fra
                      (Dorsten et al., 2007)
                      Cdc42
                      enhanceable
                      Frl
                      (Dollar et al., 2016)
                      Cdc42
                      suppressible
                      Frl
                      (Dollar et al., 2016)
                      Cdc42
                      enhanceable
                      grp
                      (Raymond et al., 2004)
                      Cdc42
                      enhanceable
                      lilli
                      (Zhu et al., 2005)
                      Cdc42
                      enhanceable
                      muc
                      (Raymond et al., 2004)
                      Cdc42
                      enhanceable
                      N
                      (Baron et al., 2000)
                      Cdc42
                      enhanceable
                      NFAT
                      (Zhu et al., 2005)
                      Cdc42
                      suppressible
                      numb
                      (Raymond et al., 2004)
                      Cdc42
                      enhanceable
                      nwk
                      (Rodal et al., 2008)
                      Cdc42
                      enhanceable
                      pbl
                      (Raymond et al., 2004)
                      Cdc42
                      suppressible
                      poe
                      (Raymond et al., 2004)
                      Cdc42
                      enhanceable
                      Tao
                      (Zhu et al., 2005)
                      Cdc42
                      enhanceable
                      Tlk
                      (Zhu et al., 2005)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      bnl
                      suppressible
                      Cdc42
                      (Wolf et al., 2002)
                      btl
                      suppressible
                      Cdc42
                      (Mukherjee et al., 2012)
                      Cip4
                      enhanceable
                      Cdc42|WASp
                      (Nahm et al., 2010)
                      Cip4
                      enhanceable
                      Cdc42
                      (Nahm et al., 2010)
                      CycB
                      suppressible
                      Cdc42
                      (Ji et al., 2002)
                      Dyb
                      suppressible
                      Cdc42
                      (Jantrapirom et al., 2019)
                      exp
                      suppressible
                      Cdc42
                      (Iordanou et al., 2014)
                      Frl
                      enhanceable
                      Cdc42
                      (Dollar et al., 2016)
                      Frl
                      suppressible
                      Cdc42
                      (Dollar et al., 2016)
                      kermit
                      enhanceable
                      Cdc42
                      (Djiane and Mlodzik, 2010)
                      LIMK1
                      suppressible
                      Cdc42
                      (Ng and Luo, 2004)
                      msn
                      enhanceable
                      Cdc42
                      (Ruan et al., 2002)
                      Mtl
                      enhanceable
                      Cdc42
                      (Muñoz-Descalzo et al., 2007)
                      Mtl
                      suppressible
                      Cdc42
                      (Muñoz-Descalzo et al., 2007)
                      Mtl|Rac1|Rac2
                      enhanceable
                      Cdc42
                      (Muñoz-Descalzo et al., 2007)
                      ninaE
                      suppressible
                      Cdc42
                      (Chang and Ready, 2000)
                      nwk
                      enhanceable
                      Cdc42
                      (Rodal et al., 2008)
                      nwk
                      suppressible
                      Cdc42
                      (Rodal et al., 2008)
                      Pak
                      suppressible
                      Cdc42
                      (Ng and Luo, 2004)
                      pbl
                      suppressible
                      Cdc42
                      (Murray et al., 2012)
                      Pvr
                      enhanceable
                      Cdc42
                      (Ishimaru et al., 2004)
                      Ras85D
                      enhanceable
                      Cdc42
                      (Pagliarini and Xu, 2003)
                      Rho1
                      suppressible
                      Cdc42
                      (Warner and Longmore, 2009)
                      robo1
                      suppressible
                      Cdc42
                      (Fritz and VanBerkum, 2002)
                      Sos
                      enhanceable
                      Cdc42
                      (Fritz and VanBerkum, 2002)
                      ssh
                      suppressible
                      Cdc42
                      (Ng and Luo, 2004)
                      tkv
                      suppressible
                      Cdc42
                      (Ricos et al., 1999)
                      trc
                      enhanceable
                      Cdc42
                      (He et al., 2005)
                      tum
                      suppressible
                      Cdc42
                      (Sotillos and Campuzano, 2000)
                      WASp
                      enhanceable
                      Cdc42|Cip4
                      (Nahm et al., 2010)
                      WASp
                      enhanceable
                      Cdc42
                      (Nahm et al., 2010)
                      Zir
                      suppressible
                      Cdc42
                      (Sampson et al., 2012)
                      External Data
                      Subunit Structure (UniProtKB)
                      Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).
                      (UniProt, P40793 )
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Signaling Pathways (FlyBase)
                      Pvr Signaling Pathway Core Components -
                      PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
                      Metabolic Pathways
                      External Data
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      X
                      Recombination map
                      1-64
                      Cytogenetic map
                      18E1-18E1
                      Sequence location
                      X:19,697,091..19,699,938 [+]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      18E1-18E1
                      Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      18E-18E
                      (determined by in situ hybridisation)
                      (Sasamura et al., 1997)
                      18D-18D
                      (determined by in situ hybridisation)
                      (Sasamura, 1995)
                      Experimentally Determined Recombination Data
                      Location

                      1-64

                      (FlyBase, 2016)

                      1-62.4

                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (33)
                      Genomic Clones (9)
                       

                      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                      cDNA Clones (187)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of
                      Source for database merge of
                      Additional comments

                      The Rac2 gene may have been derived from the Cdc42 gene by retroposition.

                      (Dai et al., 2006)
                      Other Comments

                      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                      (Stroschein-Stevenson et al., 2006)

                      Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

                      (Agaisse et al., 2005)

                      Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

                      (Philips et al., 2005)

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)

                      RNAi generated by PCR using primers directed to this gene causes a cell shape change from round to polarized when assayed in Kc167 cells, with the formation of F-actin puncta and microtubule extensions. For both Kc167 and S2R+ cells, reduced F-actin and altered cell shape occur.

                      (Kiger et al., 2003)

                      dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                      (Rogers et al., 2003)

                      Cdc42 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.

                      (Fritz and VanBerkum, 2002)

                      Cdc42 is necessary for cellular extenion formation, but not for actin cable formation during wound healing in the embryo.

                      (Wood et al., 2002)

                      Cdc42 may be a negative regulator of N signalling.

                      (Baron et al., 2000)

                      Cdc42 has a role in actin filament assembly and plays a role on intercellular interactions between the germ-line and the somatic follicle cells.

                      (Genova et al., 2000)

                      Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.

                      (Agnes et al., 1999)

                      Cdc42 has a function in dendritic development.

                      (Gao et al., 1999)

                      ISNb growth cones require Cdc42 for extension to appropriate targets.

                      (Kaufmann et al., 1998)

                      Cdc42 is not allelic to btdl.

                      (Fehon et al., 1997)

                      Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.

                      (Glise and Noselli, 1997)

                      Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.

                      (Murphy and Montell, 1996)

                      Comparison of expression of constitutively active or dominantly negative Cdc42 and Rac1 mutants demonstrates that similar GTPases in the same subfamily have unique roles in morphogenesis in vivo.

                      (Luo et al., 1994)
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 80 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DRscDB
                      EMBL-EBI Single Cell Expression Atlas
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL
                      modMine - A data warehouse for the modENCODE project
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      FlyMine - An integrated database for Drosophila genomics
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      Synonyms and Secondary IDs (18)
                      Reported As
                      Symbol Synonym
                      CDC-42
                      (Jouette et al., 2017)
                      CDC42
                      (Majumdar and Liu, 2020, Qin et al., 2020, Sundaram, 2015, Wang et al., 2014, Margolis and Borg, 2005, Mirey et al., 2003, Pastor-Pareja et al., 2001, Schejter et al., 2001, Mushegian et al., 1998, O'Leary et al., 1998, Barrett et al., 1997, Eaton, 1997, Eaton, 1997, Tanaka and Sabry, 1995, Harden et al., 1993)
                      CG12530
                      (Meadows, 2017.1.11, Schertel et al., 2013, Christis and Munro, 2012, Howell et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Li et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Derré et al., 2007, Dai et al., 2006, Colicelli, 2004, Rogers et al., 2003)
                      Cdc-42
                      (Lang and Munro, 2017)
                      Cdc42
                      (Bischoff et al., 2021, Kapoor et al., 2021, Wang et al., 2021, Dong et al., 2020, Mlodzik, 2020, Nakamura et al., 2020, Oliveira da Silva et al., 2020, Sidor et al., 2020, Sun et al., 2020, Verboon et al., 2020, Volovetz et al., 2020, Wang et al., 2020, Boucher et al., 2019, Chen et al., 2019, Franco and Carmena, 2019, Gao et al., 2019, Guan et al., 2019, Jantrapirom et al., 2019, Kono et al., 2019, Nunes de Almeida et al., 2019, Silver et al., 2019, Akishina et al., 2018, Carmena, 2018, Garrido-Jimenez et al., 2018, Medina, 2018, Saito et al., 2018, Schmidt and Grosshans, 2018, Spinner et al., 2018, Tsai et al., 2018, Akishina et al., 2017, Banisch et al., 2017, Colombié et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Koch et al., 2017, Lou et al., 2017, Nakamura et al., 2017, Ozasa et al., 2017, Park et al., 2017, Rui et al., 2017, Siddall and Hime, 2017, Tang et al., 2017, Ajduk and Zernicka-Goetz, 2016, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Dollar et al., 2016, Fear et al., 2016, Matsubayashi and Millard, 2016, Meehan et al., 2016, Roman-Fernandez and Bryant, 2016, Sarov et al., 2016, Schimizzi et al., 2016, Whitney et al., 2016, Flores-Benitez and Knust, 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rosa et al., 2015, Verboon and Parkhurst, 2015, Verboon et al., 2015, Vlisidou and Wood, 2015, Abreu-Blanco et al., 2014, Iordanou et al., 2014, Jones et al., 2014, Lammel et al., 2014, Pichaud, 2014, Sailem et al., 2014, Sharifai et al., 2014, Swope et al., 2014, Yashiro et al., 2014, Beckett et al., 2013, Bergstralh et al., 2013, Chen et al., 2013, Leibfried et al., 2013, Melzer et al., 2013, Muha and Müller, 2013, Neisch et al., 2013, Puram and Bonni, 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Zhang et al., 2013, Zhu, 2013, Abreu-Blanco et al., 2012, Baek et al., 2012, Fabian and Brill, 2012, Gates, 2012, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Murray et al., 2012, Peltan et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Tepass, 2012, Tsubouchi et al., 2012, Zoller and Schulz, 2012, Clark et al., 2011, Fauvarque and Williams, 2011, Gontang et al., 2011, Jones and Metzstein, 2011, Laprise and Tepass, 2011, Meiklejohn et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Pilgram et al., 2011, Qian et al., 2011, Razzell et al., 2011, Rotkopf et al., 2011, Song and Giniger, 2011, Tanaka et al., 2011, Zhang et al., 2011, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, Colosimo et al., 2010, D'Ambrosio and Vale, 2010, Dorsten et al., 2010, Elsaesser et al., 2010, Garlena et al., 2010, Georgiou and Baum, 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Quinones et al., 2010, Robinson et al., 2010, Sato et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Venken et al., 2010, Walther and Pichaud, 2010, Warner, 2010.9.15, Warner et al., 2010, Asano et al., 2009, Frank et al., 2009, Fricke et al., 2009, Gupta et al., 2009, Hirano et al., 2009, Kamiyama and Chiba, 2009, Liu et al., 2009, Patch et al., 2009, van Impel et al., 2009, Warner and Cook, 2009.11.19, Warner and Longmore, 2009, Warner and Longmore, 2009, Bakal et al., 2008, Harris and Tepass, 2008, Harris and Tepass, 2008, Kim et al., 2008, Larson et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Rodal et al., 2008, Vogler et al., 2008, Warren-Paquin et al., 2008, Zhou et al., 2008, Atwood et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beltran et al., 2007, Colinet et al., 2007, Derré et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Jovceva et al., 2007, Leibfried et al., 2007, Muñoz-Descalzo et al., 2007, Taniguchi et al., 2007, Tepass and Harris, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Hozumi et al., 2006, Humbert et al., 2006, Kerkhoff, 2006, Nahm et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Talbot and VanBerkum, 2006, Avet-Rochex et al., 2005, Cho et al., 2005, Go, 2005, Sen et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hofmann et al., 2004, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Gao and Bogert, 2003, Rogers et al., 2003, Kim et al., 2002, Wolf et al., 2002)
                      Cdc42Dm
                      (Zhang et al., 1999)
                      D-CDC42
                      (Ip and Davis, 1998)
                      D-Cdc42
                      (Knust, 1997)
                      D-cdc42
                      (Ryabinina et al., 2006)
                      DCDC42
                      (Hummel et al., 2000, Sasamura et al., 1995)
                      DCdc42
                      (Blanke and Jackle, 2006, Van Aelst and Symons, 2002, Dobens et al., 2001, Dobens et al., 2000, Paladi and Tepass, 2000, Sotillos and Campuzano, 2000, Szuts and Bienz, 2000, Hacker and Perrimon, 1998, Martin-Blanco, 1997, Van Aelst and D'Souza-Schorey, 1997)
                      Dcdc42
                      (Shuai et al., 2010, Dorsten et al., 2007, He et al., 2005, Xia and Karin, 2004, He and Adler, 2003, Vasenkova et al., 2003, Adler, 2002, Harden et al., 2002, He and Adler, 2002, Kim et al., 2002, Noselli, 2002, Sem et al., 2002, Zahedi et al., 2002, Dawber et al., 2001, Harden et al., 2001, Luginbuhl et al., 2001, Raymond et al., 2001, Raymond et al., 2001, Suzanne et al., 2001, Zarske et al., 2001, Allen et al., 2000, Baron et al., 2000, Benlali et al., 2000, Dobens and Raftery, 2000, Jacobs et al., 2000, Kim and Chiba, 2000, Muller, 2000, Raymond et al., 2000, Agnes and Noselli, 1999, Agnes and Noselli, 1999, Agnes et al., 1999, Gao et al., 1999, Harden et al., 1999, Harden et al., 1999, Noselli and Agnes, 1999, Paululat et al., 1999, Ricos et al., 1999, Ricos et al., 1999, Stronach and Perrimon, 1999, Goberdhan and Wilson, 1998, Noselli, 1998, Zohn et al., 1998, Luo et al., 1997, Sasamura et al., 1997, Sone et al., 1997, Eaton et al., 1995, Luo et al., 1995, Luo, 1994.7.5, Luo et al., 1994)
                      Dm Cdc42
                      (Jekely, 2003)
                      DmCDC42
                      (Mentzel and Raabe, 2005, Piekny et al., 2005)
                      Dmcdc42
                      (Riesgo-Escovar et al., 1996)
                      P40793
                      (Rojas et al., 2012)
                      cdc42
                      (DeAngelis et al., 2021, Fic et al., 2021, Khoury and Bilder, 2020, Popkova et al., 2020, Barr et al., 2019, Hao and Jin, 2017, Liu et al., 2016, Ruan et al., 2016, Hosono et al., 2015, Kamiyama et al., 2015, Ugrankar et al., 2015, de Vreede et al., 2014, Jalvingh et al., 2014, Pereira et al., 2014, Bergstralh et al., 2013, Cook et al., 2012, Fletcher et al., 2012, Mukherjee et al., 2012, Miles et al., 2011, Ohsawa et al., 2011, Chang et al., 2010, Djiane and Mlodzik, 2010, Nahm et al., 2010, Higuchi et al., 2009, Kamiyama and Chiba, 2009, Qian and Bodmer, 2009, van Impel et al., 2009, Georgiou et al., 2008, Leibfried et al., 2008, Llense and Martín-Blanco, 2008, McGraw et al., 2008, Rodal et al., 2008, Atwood et al., 2007, Avet-Rochex et al., 2007, Schafer et al., 2007, Huelsmann et al., 2006, Houalla et al., 2005, Leptin, 2005, Zhu et al., 2005, Ng and Luo, 2004, Polesello and Payre, 2004, Pagliarini and Xu, 2003, Rogers et al., 2003, Mlodzik, 2002, Pandur et al., 2002, Ruan et al., 2002, Jhaveri and Rodrigues, 2001, Kadam and Reuter, 2001, Sepp and Auld, 2001, Schock and Perrimon, 2000, Asha et al., 1999, Nairz and Hafen, 1999, Prokopenko et al., 1999, Sawamoto et al., 1999, Sawamoto et al., 1999, Boutros et al., 1998, Matova et al., 1998, Nolan et al., 1998, Matova et al., 1997, Murphy and Montell, 1995)
                      Name Synonyms
                      Cdc42
                      (Frank, 2014, Melzer et al., 2013, Cammarato et al., 2011, Robinson et al., 2010, Patch et al., 2009, Zhou et al., 2008, Wolf et al., 2002)
                      Cdc42-like
                      Secondary FlyBase IDs
                      • FBgn0012059
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (557)