Dcdc42, DmCDC42
Please see the JBrowse view of Dmel\Cdc42 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.40
Gene model reviewed during 5.47
Gene model reviewed during 5.55
2.3 (northern blot)
191 (aa)
Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550). When GTP-bound, interacts with Pak (PubMed:8628256).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc42 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
Cdc42 is expressed in all developmental stages. It is expressed ubiquitously in embryos.
Cdc42 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Cdc42 in GBrowse 2
1-64
1-62.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi generated by PCR using primers directed to this gene causes a cell shape change from round to polarized when assayed in Kc167 cells, with the formation of F-actin puncta and microtubule extensions. For both Kc167 and S2R+ cells, reduced F-actin and altered cell shape occur.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Cdc42 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.
Cdc42 is necessary for cellular extenion formation, but not for actin cable formation during wound healing in the embryo.
Cdc42 has a role in actin filament assembly and plays a role on intercellular interactions between the germ-line and the somatic follicle cells.
Cdc42 has a function in dendritic development.
ISNb growth cones require Cdc42 for extension to appropriate targets.
