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General Information
Symbol
Dmel\Cdc42
Species
D. melanogaster
Name
Cdc42
Annotation Symbol
CG12530
Feature Type
FlyBase ID
FBgn0010341
Gene Model Status
Stock Availability
Gene Summary
Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
Also Known As

Dcdc42, DmCDC42

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
1-64
RefSeq locus
NC_004354 REGION:19697091..19699938
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (66 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Whamy; FB:FBgn0037750
inferred from physical interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VXE5
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9W1B0
(assigned by UniProt )
inferred from physical interaction with FLYBASE:mbt; FB:FBgn0025743
inferred from physical interaction with FLYBASE:Pak3; FB:FBgn0044826
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
Biological Process (52 terms)
Terms Based on Experimental Evidence (45 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
involved_in axon extension
inferred from genetic interaction with FLYBASE:Frl; FB:FBgn0267795
involved_in axon guidance
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in dorsal closure
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in hemocyte migration
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
involved_in phagocytosis
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Zir; FB:FBgn0031216
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in wound healing
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
traceable author statement
involved_in axonogenesis
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
involved_in cell migration
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
involved_in cellularization
traceable author statement
involved_in dorsal closure
traceable author statement
involved_in endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
involved_in oogenesis
traceable author statement
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
inferred from direct assay
located_in axon
inferred from direct assay
located_in cell cortex
inferred from direct assay
located_in cytoplasm
located_in growth cone
inferred from direct assay
located_in lamellipodium
inferred from direct assay
(assigned by UniProt )
located_in nucleus
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
located_in rhabdomere
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (P40793)
Summaries
Gene Snapshot
Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions (PubMed:12490550). Together with mbt and Frl, regulates photoreceptor cell morphogenesis (PubMed:12490550, PubMed:26801180). Together with Frl, has a role in the neuronal development of mushroom bodies (PubMed:26801180).
(UniProt, P40793)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cdc42 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P40793)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.40

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074751
1392
191
FBtr0309214
2078
191
FBtr0309215
2005
191
Additional Transcript Data and Comments
Reported size (kB)

2.3 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074520
21.4
191
7.21
FBpp0301153
21.4
191
7.21
FBpp0301154
21.4
191
7.21
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

191 aa isoforms: Cdc42-PA, Cdc42-PC, Cdc42-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550). When GTP-bound, interacts with Pak (PubMed:8628256).

(UniProt, P40793)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc42 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Cdc42 is expressed in all developmental stages. It is expressed ubiquitously in embryos.

Cdc42 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
located_in axon
inferred from direct assay
located_in cell cortex
inferred from direct assay
located_in cytoplasm
located_in growth cone
inferred from direct assay
located_in lamellipodium
inferred from direct assay
(assigned by UniProt )
located_in nucleus
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
located_in rhabdomere
inferred from mutant phenotype
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc42 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 52 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdc42
Transgenic constructs containing regulatory region of Cdc42
Aberrations (Deficiencies and Duplications) ( 6 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdominal posterior fascicle neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
aCC neuron & dendrite, with Scer\GAL4eve.RN2
actin filament & rhabdomere | somatic clone
antenna & glial cell, with Scer\GAL4Mz317
antenna & sensory neuron, with Scer\GAL4Mz317
dorsal multidendritic neuron & dendrite & embryo, with Scer\GAL460
embryonic hemocyte & leading edge, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
macrochaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
mesothoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
metathoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
microchaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
microchaeta & wing, with Scer\GAL4ptc-559.1
nurse cell & actin filament | germ-line clone | maternal effect
RP2 neuron & cell body, with Scer\GAL4eve.RN2
RP2 neuron & dendrite, with Scer\GAL4eve.RN2
RP2 neuron & neurite, with Scer\GAL4eve.RN2
tergal depressor of trochanter muscle motor neuron & dendrite, with Scer\GAL4shakB.lethal.4.1
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
0  
4 of 15
No
Yes
3 of 15
No
No
3  
3 of 15
No
No
1  
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
4  
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
4 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
12 of 13
Yes
Yes
4 of 13
No
Yes
3 of 13
No
No
3 of 13
No
No
3 of 13
No
No
3 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
11 of 12
Yes
Yes
4 of 12
No
Yes
3 of 12
No
No
3 of 12
No
No
3 of 12
No
Yes
3 of 12
No
No
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (41)
13 of 15
Yes
Yes
10 of 15
No
Yes
6 of 15
No
Yes
4 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
12 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
No
6 of 9
Yes
Yes
5 of 9
No
No
5 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
13 of 15
Yes
Yes
1  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
11 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
6 of 10
6 of 10
6 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
RNA-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550). When GTP-bound, interacts with Pak (PubMed:8628256).
(UniProt, P40793 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Metabolic Pathways
FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-64
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
18E1-18E1
Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
18E-18E
(determined by in situ hybridisation)
18D-18D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (33)
Genomic Clones (9)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (187)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Additional comments

The Rac2 gene may have been derived from the Cdc42 gene by retroposition.

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

RNAi generated by PCR using primers directed to this gene causes a cell shape change from round to polarized when assayed in Kc167 cells, with the formation of F-actin puncta and microtubule extensions. For both Kc167 and S2R+ cells, reduced F-actin and altered cell shape occur.

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

Cdc42 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.

Cdc42 is necessary for cellular extenion formation, but not for actin cable formation during wound healing in the embryo.

Cdc42 may be a negative regulator of N signalling.

Cdc42 has a role in actin filament assembly and plays a role on intercellular interactions between the germ-line and the somatic follicle cells.

Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.

Cdc42 has a function in dendritic development.

ISNb growth cones require Cdc42 for extension to appropriate targets.

Cdc42 is not allelic to btdl.

Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.

Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.

Comparison of expression of constitutively active or dominantly negative Cdc42 and Rac1 mutants demonstrates that similar GTPases in the same subfamily have unique roles in morphogenesis in vivo.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 83 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (18)
Reported As
Symbol Synonym
Cdc42
(Bischoff et al., 2021, Kapoor et al., 2021, Loganathan et al., 2021, Noyes et al., 2021, Popkova et al., 2021, Wang et al., 2021, Yeates and Frank, 2021, Dong et al., 2020, Jossin, 2020, Luo et al., 2020, Mlodzik, 2020, Nakamura et al., 2020, Oliveira da Silva et al., 2020, Sidor et al., 2020, Sun et al., 2020, Verboon et al., 2020, Volovetz et al., 2020, Wang et al., 2020, Boucher et al., 2019, Chen et al., 2019, Franco and Carmena, 2019, Gao et al., 2019, Guan et al., 2019, Jantrapirom et al., 2019, Kono et al., 2019, Nunes de Almeida et al., 2019, Silver et al., 2019, Akishina et al., 2018, Carmena, 2018, Garrido-Jimenez et al., 2018, Medina, 2018, Saito et al., 2018, Schmidt and Grosshans, 2018, Spinner et al., 2018, Tsai et al., 2018, Akishina et al., 2017, Banisch et al., 2017, Colombié et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Koch et al., 2017, Lou et al., 2017, Nakamura et al., 2017, Ozasa et al., 2017, Park et al., 2017, Rui et al., 2017, Siddall and Hime, 2017, Tang et al., 2017, Ajduk and Zernicka-Goetz, 2016, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Dollar et al., 2016, Fear et al., 2016, Matsubayashi and Millard, 2016, Meehan et al., 2016, Roman-Fernandez and Bryant, 2016, Sarov et al., 2016, Schimizzi et al., 2016, Whitney et al., 2016, Flores-Benitez and Knust, 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rosa et al., 2015, Verboon and Parkhurst, 2015, Verboon et al., 2015, Vlisidou and Wood, 2015, Abreu-Blanco et al., 2014, Iordanou et al., 2014, Jones et al., 2014, Lammel et al., 2014, Pichaud, 2014, Sailem et al., 2014, Sharifai et al., 2014, Swope et al., 2014, Yashiro et al., 2014, Beckett et al., 2013, Bergstralh et al., 2013, Chen et al., 2013, Leibfried et al., 2013, Melzer et al., 2013, Muha and Müller, 2013, Neisch et al., 2013, Puram and Bonni, 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Zhang et al., 2013, Zhu, 2013, Abreu-Blanco et al., 2012, Baek et al., 2012, Fabian and Brill, 2012, Gates, 2012, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Murray et al., 2012, Peltan et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Tepass, 2012, Tsubouchi et al., 2012, Zoller and Schulz, 2012, Clark et al., 2011, Fauvarque and Williams, 2011, Gontang et al., 2011, Jones and Metzstein, 2011, Laprise and Tepass, 2011, Meiklejohn et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Pilgram et al., 2011, Qian et al., 2011, Razzell et al., 2011, Rotkopf et al., 2011, Song and Giniger, 2011, Tanaka et al., 2011, Zhang et al., 2011, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, Colosimo et al., 2010, D'Ambrosio and Vale, 2010, Dorsten et al., 2010, Elsaesser et al., 2010, Garlena et al., 2010, Georgiou and Baum, 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Quinones et al., 2010, Robinson et al., 2010, Sato et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Venken et al., 2010, Walther and Pichaud, 2010, Warner, 2010.9.15, Warner et al., 2010, Asano et al., 2009, Frank et al., 2009, Fricke et al., 2009, Gupta et al., 2009, Hirano et al., 2009, Kamiyama and Chiba, 2009, Liu et al., 2009, Patch et al., 2009, van Impel et al., 2009, Warner and Cook, 2009.11.19, Warner and Longmore, 2009, Warner and Longmore, 2009, Bakal et al., 2008, Harris and Tepass, 2008, Harris and Tepass, 2008, Kim et al., 2008, Larson et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Rodal et al., 2008, Vogler et al., 2008, Warren-Paquin et al., 2008, Zhou et al., 2008, Atwood et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beltran et al., 2007, Colinet et al., 2007, Derré et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Jovceva et al., 2007, Leibfried et al., 2007, Muñoz-Descalzo et al., 2007, Taniguchi et al., 2007, Tepass and Harris, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Hozumi et al., 2006, Humbert et al., 2006, Kerkhoff, 2006, Nahm et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Talbot and VanBerkum, 2006, Avet-Rochex et al., 2005, Cho et al., 2005, Go, 2005, Sen et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hofmann et al., 2004, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Gao and Bogert, 2003, Rogers et al., 2003, Kim et al., 2002, Wolf et al., 2002)
D-Cdc42
Dm Cdc42
Secondary FlyBase IDs
  • FBgn0012059
Datasets (8)
Study focus (0)
Experimental Role
Project
Project Type
Title
Study result (8)
Result
Result Type
Title
Clustering analysis of hemocytes from non-infested third instar larvae
Clustering analysis of hemocytes from wasp-infested third instar larvae
Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
References (565)