FB2020_01, released Feb 12, 2020

Gene: Dmel\Cdc42

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General Information
Symbol
Dmel\Cdc42
Species
D. melanogaster
Name
Cdc42
Annotation Symbol
CG12530
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010341
Gene Model Status
Current
Stock Availability
30 publicly available
Gene Snapshot
Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Dcdc42, DmCDC42

Key Links
Genomic Location
Cytogenetic map
18E1-18E1
Sequence location
X:19,697,091..19,699,938 [+]
Recombination map

1-64

RefSeq locus
NC_004354 REGION:19697091..19699938
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (P40793)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
GTPase activating protein binding; GTPase activity; protein binding; protein kinase binding
Predictions / Assertions
GTP binding; GTPase activity; protein kinase binding
Summaries
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Pathway (FlyBase)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions (PubMed:12490550). Together with mbt and Frl, regulates photoreceptor cell morphogenesis (PubMed:12490550, PubMed:26801180). Together with Frl, has a role in the neuronal development of mushroom bodies (PubMed:26801180).
(UniProt, P40793)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Cdc42 or the JBrowse view of Dmel\Cdc42 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.40

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cdc42-RA
FBtr0074751
NM_078690
1392
191
Cdc42-RC
FBtr0309214
NM_001258833
2078
191
Cdc42-RD
FBtr0309215
NM_001258834
2005
191
Additional Transcript Data and Comments
Reported size (kB)

2.3 (northern blot)

(Luo et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cdc42-PA
FBpp0074520
21.4
191
7.21
NP_523414
AAF49007
Cdc42-PC
FBpp0301153
21.4
191
7.21
NP_001245762
AFH07474
Cdc42-PD
FBpp0301154
21.4
191
7.21
NP_001245763
AFH07475
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

191 aa isoforms: Cdc42-PA, Cdc42-PC, Cdc42-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

191 (aa)

(Luo et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).

(UniProt, P40793)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc42 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (74 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
GTPase activating protein binding
inferred from physical interaction with FLYBASE:RacGAP84C; FB:FBgn0045843
(Raymond et al., 2001)
GTPase activity
inferred from direct assay
(Raymond et al., 2001)
protein binding
inferred from physical interaction with FLYBASE:Whamy; FB:FBgn0037750
(Liu et al., 2009)
inferred from physical interaction with UniProtKB:Q9W1B0
(assigned by UniProt )
(Luo et al., 1997)
inferred from physical interaction with UniProtKB:Q9VXE5
(assigned by UniProt )
(Schneeberger and Raabe, 2003)
inferred from physical interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
(Dollar et al., 2016)
protein kinase binding
inferred from physical interaction with FLYBASE:mbt; FB:FBgn0025743
(Schneeberger and Raabe, 2003)
inferred from physical interaction with FLYBASE:Pak3; FB:FBgn0044826
(Harden et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (56 terms)
Terms Based on Experimental Evidence (44 terms)
CV Term
Evidence
References
actin cytoskeleton reorganization
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
actin filament polymerization
inferred from mutant phenotype
(Eaton et al., 1996)
axon extension
inferred from genetic interaction with FLYBASE:Frl; FB:FBgn0267795
(Dollar et al., 2016)
axon guidance
inferred from mutant phenotype
(Fritz and VanBerkum, 2002, Kim et al., 2002)
branch fusion, open tracheal system
inferred from mutant phenotype
(Wolf et al., 2002)
branching involved in open tracheal system development
inferred from mutant phenotype
(Jones and Metzstein, 2011)
cell projection assembly
inferred from mutant phenotype
(Kunda et al., 2003)
cortical actin cytoskeleton organization
inferred from mutant phenotype
(Kunda et al., 2003)
dendrite morphogenesis
inferred from mutant phenotype
(Kamiyama and Chiba, 2009, Sanchez-Soriano et al., 2005, Scott et al., 2003, Gao et al., 1999)
dorsal appendage formation
inferred from mutant phenotype
(Suzanne et al., 2001)
dorsal closure
inferred from mutant phenotype
(assigned by UniProt )
(Sem et al., 2002)
inferred from mutant phenotype
(Riesgo-Escovar et al., 1996)
NOT dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
encapsulation of foreign target
inferred from mutant phenotype
(Sampson et al., 2012)
establishment of neuroblast polarity
inferred from mutant phenotype
(Atwood et al., 2007)
exocyst localization
inferred from mutant phenotype
(Jones et al., 2014)
hemocyte migration
inferred from mutant phenotype
(Stramer et al., 2005)
imaginal disc-derived wing hair outgrowth
inferred from mutant phenotype
(Eaton et al., 1996)
maintenance of cell polarity
inferred from mutant phenotype
(Stramer et al., 2005)
maintenance of protein location
inferred from mutant phenotype
(assigned by UniProt )
(Schneeberger and Raabe, 2003)
melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
motor neuron axon guidance
inferred from mutant phenotype
(Dorsten et al., 2007)
nephrocyte filtration
inferred from mutant phenotype
(Zhang et al., 2013)
neuromuscular synaptic transmission
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
(Pilgram et al., 2011)
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
(Pilgram et al., 2011)
neuron projection development
inferred from mutant phenotype
(Allen et al., 2000)
neuron projection morphogenesis
inferred from mutant phenotype
(Petsakou et al., 2015)
ommatidial rotation
inferred from genetic interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
(Dollar et al., 2016)
phagocytosis
inferred from mutant phenotype
(Sampson et al., 2012)
positive regulation of filopodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010, Wolf et al., 2002)
positive regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
positive regulation of lamellipodium assembly
inferred from mutant phenotype
(Georgiou and Baum, 2010)
positive regulation of protein kinase activity
inferred from mutant phenotype
(assigned by UniProt )
(Schneeberger and Raabe, 2003)
positive regulation of wound healing
inferred from mutant phenotype
(Abreu-Blanco et al., 2014)
protein localization to plasma membrane
inferred from mutant phenotype
(Jones et al., 2014)
regulation of actin filament polymerization
inferred from direct assay
(Rodal et al., 2008)
inferred from mutant phenotype
(Rotkopf et al., 2011)
regulation of axonogenesis
inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712
(Ng and Luo, 2004)
regulation of cell shape
inferred from mutant phenotype
(Kunda et al., 2003)
regulation of synaptic growth at neuromuscular junction
inferred from direct assay
(Nahm et al., 2010)
inferred from mutant phenotype
(Rodal et al., 2008)
response to wounding
inferred from mutant phenotype
(Nakamura et al., 2017)
Rho protein signal transduction
inferred from genetic interaction with FLYBASE:Zir; FB:FBgn0031216
(Sampson et al., 2012)
sensory perception of touch
inferred from mutant phenotype
(Tsubouchi et al., 2012)
spermatid development
inferred from mutant phenotype
(Rotkopf et al., 2011)
vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:Pvr; FB:FBgn0032006
(Ishimaru et al., 2004)
vesicle-mediated transport
inferred from mutant phenotype
(Jones et al., 2014)
wound healing
inferred from mutant phenotype
(Abreu-Blanco et al., 2012, Wood et al., 2002)
Terms Based on Predictions or Assertions (16 terms)
CV Term
Evidence
References
actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Johnstone and Lasko, 2001)
actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
axonogenesis
traceable author statement
(Gao et al., 1999)
Cdc42 protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
cell migration
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
cell projection assembly
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
cellularization
traceable author statement
(Mazumdar and Mazumdar, 2002)
cortical cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
dorsal closure
traceable author statement
(Harden, 2002, Noselli and Agnes, 1999)
endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
(Gaudet et al., 2011)
establishment or maintenance of cell polarity
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
oogenesis
traceable author statement
(Harden, 2002)
ovarian follicle cell development
traceable author statement
(Dobens and Raftery, 2000)
regulation of actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of cell shape
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Rho protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (13 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
apical part of cell
inferred from direct assay
(Fletcher et al., 2012)
axon
inferred from direct assay
(Kamiyama and Chiba, 2009)
cell cortex
inferred from direct assay
(Leibfried et al., 2013)
cytoplasm
inferred from direct assay
(Leibfried et al., 2013, Kamiyama and Chiba, 2009)
growth cone
inferred from direct assay
(Kim et al., 2002)
lamellipodium
inferred from direct assay
(assigned by UniProt )
(Shim et al., 2010)
nucleus
inferred from direct assay
(Kamiyama and Chiba, 2009)
plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
rhabdomere
inferred from mutant phenotype
(Zelhof and Hardy, 2004)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
cell cortex
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
cell projection
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
cytoplasmic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
intracellular membrane-bounded organelle
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Sasamura et al., 1997)
presumptive embryonic/larval central nervous system
(Luo et al., 1994)
embryonic/larval digestive system
(Luo et al., 1994)
embryonic stage 10 -- 12
somatic mesoderm
(Luo et al., 1994)
blastoderm stage
organism | ubiquitous
(Luo et al., 1994)
embryonic stage -- adult stage
(Sasamura et al., 1997, Luo et al., 1994)
Additional Descriptive Data

Cdc42 is expressed in all developmental stages. It is expressed ubiquitously in embryos.

(Sasamura et al., 1997)

Cdc42 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.

(Luo et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
apical part of cell
inferred from direct assay
(Fletcher et al., 2012)
axon
inferred from direct assay
(Kamiyama and Chiba, 2009)
cell cortex
inferred from direct assay
(Leibfried et al., 2013)
cytoplasm
inferred from direct assay
(Leibfried et al., 2013, Kamiyama and Chiba, 2009)
growth cone
inferred from direct assay
(Kim et al., 2002)
lamellipodium
inferred from direct assay
(assigned by UniProt )
(Shim et al., 2010)
nucleus
inferred from direct assay
(Kamiyama and Chiba, 2009)
plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
rhabdomere
inferred from mutant phenotype
(Zelhof and Hardy, 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc42 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 46 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdc42
Transgenic constructs containing regulatory region of Cdc42
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4198Y
lethal, with Scer\GAL4238Y
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4hs.PB
lethal | female, with Scer\GAL4306
lethal | recessive
lethal | somatic clone
lethal - all die before end of embryonic stage, with Scer\GAL469B
lethal - all die before end of embryonic stage, with Scer\GAL4en-e16E
lethal - all die before end of embryonic stage, with Scer\GAL4how-24B
lethal - all die before end of embryonic stage | maternal effect | partially (with Cdc423)
lethal - all die before end of embryonic stage | maternal effect | partially (with Cdc424)
lethal - all die before end of embryonic stage | maternal effect | partially (with Cdc426)
lethal - all die before end of embryonic stage | non-rescuable maternal effect
lethal - all die before end of larval stage, with Scer\GAL4109-30
lethal - all die before end of larval stage, with Scer\GAL4109-39
lethal - all die before end of larval stage, with Scer\GAL4109-53
lethal - all die before end of larval stage, with Scer\GAL4109-69
lethal - all die before end of larval stage, with Scer\GAL4109-79
lethal - all die before end of larval stage, with Scer\GAL4sca-109-68
lethal - all die before end of pupal stage, with Scer\GAL4how-24B
partially lethal, with Scer\GAL4elav.PLu
partially lethal - majority die, with Scer\GAL4212
viable
viable, with Scer\GAL4212
viable, with Scer\GAL4306
viable, with Scer\GAL4458
viable, with Scer\GAL4hs.PB
viable | heat sensitive
Sterility
Allele
male sterile, with Scer\GAL4A3.eya
Other Phenotypes
Allele
cell polarity defective
cell polarity defective, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
cell polarity defective, with Scer\GAL4wor.PA
cell polarity defective | maternal effect (with Cdc423)
cell polarity defective | maternal effect (with Cdc426)
chemical resistant, with Scer\GAL4NP1514
chemical sensitive, with Scer\GAL4NP1514
decreased cell number | adult stage, with Scer\GAL4sev.EP
decreased cell size | somatic clone
immune response defective | larval stage
memory defective | adult stage, with Scer\GAL4elav.PU
memory defective | adult stage, with Scer\GAL4ey-OK107
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4C57
neuroanatomy defective, with Scer\GAL4elav.PLu
neuroanatomy defective, with Scer\GAL4elav-C155
neuroanatomy defective, with Scer\GAL4eve.RN2
neuroanatomy defective, with Scer\GAL4Mhc.Switch.PO
neuroanatomy defective, with Scer\GAL4Mz317
neuroanatomy defective, with Scer\GAL4P0.5.Pdf
neuroanatomy defective | adult stage
neuroanatomy defective | embryonic stage 16, with Scer\GAL4ftz.ng
neuroanatomy defective | larval stage, with Scer\GAL41003.3
neuroanatomy defective | somatic clone
neuroanatomy defective | third instar larval stage
neurophysiology defective
planar polarity defective
planar polarity defective | somatic clone
size defective | third instar larval stage
some die during embryonic stage, with Scer\GAL469B
some die during embryonic stage, with Scer\GAL4en-e16E
some die during embryonic stage, with Scer\GAL4how-24B
some die during embryonic stage | non-rescuable maternal effect
some die during embryonic stage | partially (with Cdc423)
some die during embryonic stage | partially (with Cdc424)
some die during embryonic stage | partially (with Cdc426)
some die during larval stage, with Scer\GAL4109-30
some die during larval stage, with Scer\GAL4109-39
some die during larval stage, with Scer\GAL4109-53
some die during larval stage, with Scer\GAL4109-69
some die during larval stage, with Scer\GAL4109-79
some die during larval stage, with Scer\GAL4sca-109-68
some die during pupal stage, with Scer\GAL4how-24B
touch response defective | larval stage, with Scer\GAL41003.3
visible
visible, with Scer\GAL4en-e16E
visible (with Cdc421)
visible (with Cdc425)
visible | somatic clone
wild-type
wound healing defective, with Scer\GAL4en-e16E
wound healing defective | embryonic stage (with Cdc424)
wound healing defective | embryonic stage (with Cdc426)
Phenotype manifest in
Allele
abdominal intersegmental nerve
abdominal intersegmental nerve, with Scer\GAL4elav.PLu
abdominal posterior fascicle neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
abdominal segmental nerve, with Scer\GAL4elav.PLu
abdominal segmental nerve, with Scer\GAL4elav-C155
aCC neuron, with Scer\GAL4eve.RN2
aCC neuron & dendrite, with Scer\GAL4eve.RN2
actin filament, with Scer\GAL4T155
actin filament & rhabdomere | somatic clone
actin filament | germline clone | maternal effect (with Cdc424)
actin filament | germline clone | maternal effect (with Cdc426)
adult antennal lobe commissure, with Scer\GAL4SG18.1
adult heart, with Scer\GAL4how-24B
adult heart, with Scer\GAL4tin.CΔ4
antenna & glial cell, with Scer\GAL4Mz317
antenna & sensory neuron, with Scer\GAL4Mz317
antennal lobe glomerulus, with Scer\GAL4SG18.1
anterior crossvein | ectopic
anterior crossvein | ectopic (with Cdc421)
anterior crossvein | ectopic (with Cdc425)
anterior-posterior compartment boundary of the wing disc, with Scer\GAL4ptc-559.1
axon
axon | adult stage
bouton
bouton, with Scer\GAL4C57
bouton, with Scer\GAL4Mhc.Switch.PO
cardiac myofibril, with Scer\GAL4how-24B
cardiac myofibril, with Scer\GAL4tin.CΔ4
cardial cell, with Scer\GAL4how-24B
cardial cell, with Scer\GAL4tin.CΔ4
crossvein | cell non-autonomous | ectopic, with Scer\GAL4Bx-MS1096
crossvein | ectopic
crossvein | supernumerary, with Scer\GAL4en-e16E
dendrite
dendrite | dorsal | embryonic stage, with Scer\GAL460
dendrite | ectopic
dendritic spine
dMP2 neuron, with Scer\GAL4ftz.ng
dorsal abdominal cluster
dorsal appendage, with Scer\GAL4CY2
dorsal multidendritic neuron & dendrite & embryo, with Scer\GAL460
embryo | anterior | maternal effect (with Cdc423)
embryo | anterior | maternal effect (with Cdc426)
embryo | dorsal closure stage, with Scer\GAL4en-e16E
embryo | dorsal closure stage | heat sensitive, with Scer\GAL4hs.PB
embryo | dorsal closure stage | maternal effect (with Cdc423)
embryo | dorsal closure stage | maternal effect (with Cdc426)
embryo | maternal effect (with Cdc423)
embryo | maternal effect (with Cdc424)
embryo | maternal effect (with Cdc426)
embryonic/first instar larval cuticle, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle, with Scer\GAL4twi.PG
embryonic/first instar larval cuticle | dorsal, with Scer\GAL469B
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle | heat sensitive, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | maternal effect | ventral (with Cdc423)
embryonic/first instar larval cuticle | maternal effect | ventral (with Cdc426)
embryonic/larval anterior midgut, with Scer\GAL4NP3392
embryonic/larval dorsal trunk, with Scer\GAL4hs.2sev
embryonic/larval lateral trunk, with Scer\GAL4btl.PS
embryonic/larval midgut | embryonic stage, with Scer\GAL448Y
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval pericardial cell, with Scer\GAL4Ugt36A1.PK
embryonic/larval somatic muscle, with Scer\GAL4twi.PG
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic epidermis, with Scer\GAL4hs.PB
embryonic epidermis | dorsal, with Scer\GAL4en-e16E
embryonic epidermis | maternal effect | ventral (with Cdc423)
embryonic epidermis | maternal effect | ventral (with Cdc426)
embryonic hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic hemocyte (with Cdc423)
embryonic hemocyte (with Cdc426)
embryonic hemocyte & leading edge, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
embryonic proventriculus
embryonic proventriculus, with Scer\GAL4retn-GAL4
epithelium, with Scer\GAL4NP1624
eye
eye (with Cdc421)
eye (with Cdc425)
eye disc, with Scer\GAL4ey.PH
eye photoreceptor cell, with Scer\GAL4sev.EP
eye photoreceptor cell | somatic clone
female germline cyst, with Scer\GAL4NP1624
follicle cell, with Scer\GAL4Act5C.PP
follicle cell | somatic clone
ganglionic branch primordium
giant axon
giant fiber neuron, with Scer\GAL4shakB.lethal.4.1
glomerulus | ectopic, with Scer\GAL4SG18.1
growth cone, with Scer\GAL4elav.PLu
growth cone, with Scer\GAL4elav-C155
head cyst cell, with Scer\GAL4T155
interommatidial bristle
interommatidial bristle (with Cdc421)
interommatidial bristle (with Cdc425)
larval dorsal multidendritic neuron | embryonic stage, with Scer\GAL460
larval dorsal multidendritic neuron ddaA | larval stage, with Scer\GAL41003.3
longitudinal connective | maternal effect (with Cdc423)
longitudinal connective | maternal effect (with Cdc426)
macrochaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
macrophage
macrophage, with Scer\GAL4Col4a1-A109.1F2.P
macrophage, with Scer\GAL4da.G32
macrophage, with Scer\GAL4gcm-rA87.P
medial triple row, with Scer\GAL4Bx-MS1096
mesothoracic leg disc, with Scer\GAL4dpp.blk1
mesothoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
metathoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
microchaeta, with Scer\GAL4ptc-559.1
microchaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
microchaeta & wing, with Scer\GAL4ptc-559.1
midline crossing tract | embryonic stage 16, with Scer\GAL4ftz.ng
motor neuron, with Scer\GAL4elav.PLu
motor neuron, with Scer\GAL4elav-C155
muscle attachment site, with Scer\GAL4twi.PG
mushroom body alpha-lobe | adult stage
mushroom body beta-lobe | adult stage
myotube, with Scer\GAL4twi.PG
neurite
neuroblast | embryonic stage, with Scer\GAL4wor.PA
neuroblast | third instar larval stage
neuromuscular junction
neuromuscular junction, with Scer\GAL4C57
neuromuscular junction, with Scer\GAL4Mhc.Switch.PO
neuron, with Scer\GAL4elav.PLu
neuron, with Scer\GAL4elav-C155
NMJ bouton | third instar larval stage
nurse cell
nurse cell, with Scer\GAL4VP16.osk
nurse cell & actin filament | germ-line clone | maternal effect
nurse cell ring canal | germline clone | maternal effect (with Cdc424)
nurse cell ring canal | germline clone | maternal effect (with Cdc426)
ommatidium
ommatidium, with Scer\GAL4sev.EP
ommatidium (with Cdc421)
ommatidium (with Cdc425)
ommatidium | somatic clone
oocyte | germline clone
oocyte | germline clone | maternal effect
pCC neuron, with Scer\GAL4ftz.ng
photoreceptor
pigment cell
presumptive embryonic/larval central nervous system | maternal effect (with Cdc423)
presumptive embryonic/larval central nervous system | maternal effect (with Cdc426)
presumptive embryonic/larval peripheral nervous system | dorsal, with Scer\GAL460
presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS
proventriculus inner layer primordium
proventriculus inner layer primordium, with Scer\GAL4retn-GAL4
proventriculus intermediate layer primordium
proventriculus intermediate layer primordium, with Scer\GAL4retn-GAL4
retina | somatic clone
rhabdomere
RP2 motor neuron | ectopic, with Scer\GAL4eve.RN2
RP2 neuron & cell body, with Scer\GAL4eve.RN2
RP2 neuron & dendrite, with Scer\GAL4eve.RN2
RP2 neuron & neurite, with Scer\GAL4eve.RN2
seminal vesicle, with Scer\GAL4A3.eya
sensory dendrite | larval stage, with Scer\GAL41003.3
s-LNv Pdf neuron, with Scer\GAL4P0.5.Pdf
somatic muscle, with Scer\GAL4how-24B
spermatid cyst, with Scer\GAL4A3.eya
spermatid cyst, with Scer\GAL4T155
tergal depressor of trochanter muscle motor neuron & dendrite, with Scer\GAL4shakB.lethal.4.1
terminal tracheal cell | somatic clone
ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4ftz.ng
vertical system neuron
vMP2 neuron, with Scer\GAL4ftz.ng
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4ptc-559.1
wing (with Cdc421)
wing (with Cdc425)
wing hair, with Scer\GAL4Bx-MS1096
wing hair | ectopic, with Scer\GAL4Bx-MS1096
wing hair | somatic clone | supernumerary
wing hair | supernumerary, with Scer\GAL4en-e16E
wing margin, with Scer\GAL4Bx-MS1096
wing margin bristle, with Scer\GAL4Bx-MS1096
wing vein | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDC42
14 of 15
Yes
Yes
 
Hsap\RAC1
3 of 15
No
No
 
Hsap\RAC2
3 of 15
No
No
 
Hsap\RAC3
3 of 15
No
No
Hsap\RHOJ
3 of 15
No
Yes
Hsap\RHOG
2 of 15
No
No
Hsap\RHOQ
2 of 15
No
Yes
Hsap\RHOA
1 of 15
No
No
 
Hsap\RHOB
1 of 15
No
No
 
Hsap\RHOBTB1
1 of 15
No
No
Hsap\RHOBTB2
1 of 15
No
No
 
Hsap\RHOBTB3
1 of 15
No
No
Hsap\RHOC
1 of 15
No
No
 
Hsap\RHOD
1 of 15
No
No
Hsap\RHOF
1 of 15
No
No
Hsap\RHOH
1 of 15
No
No
Hsap\RHOU
1 of 15
No
No
Hsap\RHOV
1 of 15
No
No
Hsap\RND1
1 of 15
No
No
Hsap\RND2
1 of 15
No
No
Hsap\RND3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdc42
13 of 15
Yes
Yes
Mmus\Rac2
3 of 15
No
No
Mmus\Rac3
3 of 15
No
No
Mmus\Rhoj
3 of 15
No
Yes
Mmus\Rhoq
3 of 15
No
Yes
Mmus\Rac1
2 of 15
No
No
Mmus\Rhog
2 of 15
No
No
Mmus\4930544G11Rik
1 of 15
No
No
Mmus\Rhoa
1 of 15
No
No
Mmus\Rhob
1 of 15
No
No
Mmus\Rhobtb1
1 of 15
No
No
Mmus\Rhobtb2
1 of 15
No
No
Mmus\Rhobtb3
1 of 15
No
No
Mmus\Rhoc
1 of 15
No
No
Mmus\Rhod
1 of 15
No
No
Mmus\Rhof
1 of 15
No
No
Mmus\Rhoh
1 of 15
No
No
Mmus\Rhou
1 of 15
No
No
Mmus\Rhov
1 of 15
No
No
Mmus\Rnd1
1 of 15
No
No
Mmus\Rnd2
1 of 15
No
No
Mmus\Rnd3
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Cdc42
12 of 13
Yes
Yes
Rnor\Rac1
3 of 13
No
No
Rnor\Rac2
3 of 13
No
No
Rnor\Rhoj
3 of 13
No
Yes
Rnor\Rhoq
3 of 13
No
Yes
Rnor\Rhog
2 of 13
No
No
Rnor\Rhoa
1 of 13
No
No
Rnor\Rhob
1 of 13
No
No
Rnor\Rhobtb1
1 of 13
No
No
Rnor\Rhobtb2
1 of 13
No
No
Rnor\Rhobtb3
1 of 13
No
No
Rnor\Rhoc
1 of 13
No
No
Rnor\Rhod
1 of 13
No
No
Rnor\Rhof
1 of 13
No
No
Rnor\Rhoh
1 of 13
No
No
Rnor\Rhov
1 of 13
No
No
Rnor\Rnd2
1 of 13
No
No
Rnor\Rnd3
1 of 13
No
No
Rnor\RSA-14-44
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
Xtro\cdc42
10 of 12
Yes
Yes
Xtro\rac1
3 of 12
No
No
Xtro\rac2
2 of 12
No
No
Xtro\rac3
1 of 12
No
Yes
Xtro\rhoa.2
1 of 12
No
No
Xtro\rhoa
1 of 12
No
No
Xtro\rhobtb1
1 of 12
No
No
Xtro\rhobtb2
1 of 12
No
No
Xtro\rhobtb3
1 of 12
No
Yes
Xtro\rhob
1 of 12
No
No
Xtro\rhoc
1 of 12
No
No
Xtro\rhof
1 of 12
No
No
Xtro\rhog
1 of 12
No
No
Xtro\rhoj
1 of 12
No
Yes
Xtro\rhoq
1 of 12
No
Yes
Xtro\rhou
1 of 12
No
No
Xtro\rhov
1 of 12
No
No
Xtro\rnd1
1 of 12
No
No
Xtro\rnd3
1 of 12
No
No
Danio rerio (Zebrafish) (39)
Drer\cdc42
13 of 15
Yes
Yes
Drer\cdc42l
11 of 15
No
Yes
Drer\cdc42l2
6 of 15
No
Yes
Drer\rac1a
3 of 15
No
No
Drer\rac1b
3 of 15
No
No
Drer\rac3b
3 of 15
No
No
Drer\rhoga
3 of 15
No
No
Drer\rhoj
3 of 15
No
Yes
Drer\rhoq
3 of 15
No
Yes
Drer\rac3a
2 of 15
No
No
Drer\rhogb
2 of 15
No
No
Drer\rhogc
2 of 15
No
No
Drer\LOC100002134
1 of 15
No
No
Drer\LOC100331257
1 of 15
No
Yes
Drer\LOC100537765
1 of 15
No
No
Drer\rac1l
1 of 15
No
No
Drer\rac2
1 of 15
No
No
Drer\rhoaa
1 of 15
No
No
Drer\rhoab
1 of 15
No
No
Drer\rhoac
1 of 15
No
No
Drer\rhobtb1
1 of 15
No
No
Drer\rhobtb2a
1 of 15
No
No
Drer\rhobtb2b
1 of 15
No
No
Drer\rhoca
1 of 15
No
No
Drer\rhocb
1 of 15
No
No
Drer\rhof
1 of 15
No
No
Drer\rhogd
1 of 15
No
No
Drer\rhoh
1 of 15
No
No
Drer\rhoua
1 of 15
No
No
Drer\rhoub
1 of 15
No
No
Drer\rhov
1 of 15
No
No
Drer\rnd1a
1 of 15
No
No
Drer\rnd1b
1 of 15
No
No
Drer\rnd2
1 of 15
No
No
Drer\rnd3a
1 of 15
No
No
Drer\rnd3b
1 of 15
No
No
Drer\si:ch211-133l11.10
1 of 15
No
No
Drer\si:dkey-6b12.5
1 of 15
No
No
Drer\si:dkey-263f15.2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\cdc-42
12 of 15
Yes
Yes
Cele\mig-2
3 of 15
No
No
Cele\rac-2
3 of 15
No
No
Cele\ced-10
2 of 15
No
No
Cele\crp-1
2 of 15
No
No
Cele\chw-1
1 of 15
No
No
Cele\rho-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\ARAC1
5 of 9
Yes
No
Atha\ARAC5
5 of 9
Yes
No
Atha\ARAC9
5 of 9
Yes
No
Atha\RAC2
5 of 9
Yes
No
Atha\RAC3
5 of 9
Yes
No
Atha\RAC6
5 of 9
Yes
No
Atha\ROP1
5 of 9
Yes
No
Atha\ROP2
5 of 9
Yes
No
Atha\ROP9
5 of 9
Yes
Yes
Atha\RAC10
4 of 9
No
No
Atha\ROP10
4 of 9
No
No
Atha\AT3G51290
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\CDC42
14 of 15
Yes
Yes
 
Scer\RHO1
1 of 15
No
No
Scer\RHO2
1 of 15
No
No
Scer\RHO3
1 of 15
No
No
Scer\RHO4
1 of 15
No
No
Scer\RHO5
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cdc42
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190FXQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Cdc42
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008375
Drosophila simulans
Dsim\GD17456
Drosophila sechellia
Dsec\GM22983
Drosophila erecta
Dere\GG19248
Drosophila yakuba
Dyak\GE15867
Drosophila ananassae
Dana\GF20423
Drosophila pseudoobscura pseudoobscura
Dpse\GA11680
Drosophila persimilis
Dper\GL18265
Drosophila willistoni
Dwil\GK17312
Drosophila virilis
Dvir\GJ15962
Drosophila mojavensis
Dmoj\GI11109
Drosophila grimshawi
Dgri\GH12491
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BEP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009155
Glossina morsitans
Tsetse fly
Gmor\GMOY003464
Mayetiola destructor
Hessian fly
Mdes\Mdes006638
Aedes aegypti
Yellow fever mosquito
Aaeg\Cdc42
Anopheles darlingi
American malaria mosquito
Adar\ADAC006233
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D88 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006475
Bombyx mori
Silkmoth
Bmor\BGIBMGA007110
Bombyx mori
Silkmoth
Bmor\BGIBMGA012295
Danaus plexippus
Monarch butterfly
Dple\DPOGS210795-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203397-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210992-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016632
Heliconius melpomene
Postman butterfly
Hmel\HMEL025024
Heliconius melpomene
Postman butterfly
Hmel\HMEL007742
Apis florea
Little honeybee
Aflo\2477932532
Apis florea
Little honeybee
Aflo\2728460068
Apis florea
Little honeybee
Aflo\2154241108
Apis florea
Little honeybee
Aflo\2557575572
Apis mellifera
Western honey bee
Amel\GB45558
Apis mellifera
Western honey bee
Amel\GB45657
Apis mellifera
Western honey bee
Amel\GB55933
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12709
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15218
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17804
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18936
Bombus terrestris
Buff-tailed bumblebee
Bter\15216567
Bombus terrestris
Buff-tailed bumblebee
Bter\15211351
Bombus terrestris
Buff-tailed bumblebee
Bter\15208628
Bombus terrestris
Buff-tailed bumblebee
Bter\15216192
Linepithema humile
Argentine ant
Lhum\LH23269
Linepithema humile
Argentine ant
Lhum\LH15884
Linepithema humile
Argentine ant
Lhum\LH20173
Linepithema humile
Argentine ant
Lhum\LH17483
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0011f3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003131
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002966
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0018bc
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000948
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021442
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019951
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009052
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06840
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10346
Tribolium castaneum
Red flour beetle
Tcas\TC013187
Tribolium castaneum
Red flour beetle
Tcas\Rac1
Tribolium castaneum
Red flour beetle
Tcas\TC000961
Pediculus humanus
Human body louse
Phum\PHUM344070
Pediculus humanus
Human body louse
Phum\PHUM376850
Pediculus humanus
Human body louse
Phum\PHUM424410
Rhodnius prolixus
Kissing bug
Rpro\RPRC003442
Rhodnius prolixus
Kissing bug
Rpro\RPRC008853
Rhodnius prolixus
Kissing bug
Rpro\RPRC013286
Cimex lectularius
Bed bug
Clec\CLEC008884
Cimex lectularius
Bed bug
Clec\CLEC011807
Cimex lectularius
Bed bug
Clec\CLEC011605
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009526
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000070
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004385
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07397
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13055
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01188
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CS8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011334
Ixodes scapularis
Black-legged tick
Isca\ISCW016255
Ixodes scapularis
Black-legged tick
Isca\ISCW011749
Ixodes scapularis
Black-legged tick
Isca\ISCW003614
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77036.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61734.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68170.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g01600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g04000
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01520
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299952
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307551
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306746
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdc42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Racl1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rhop3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rac
Ciona intestinalis
Vase tunicate
Cint\LOC448958
Ciona intestinalis
Vase tunicate
Cint\LOC445702
Ciona intestinalis
Vase tunicate
Cint\LOC448957
Ciona intestinalis
Vase tunicate
Cint\rac3a
Ciona intestinalis
Vase tunicate
Cint\rac2
Gallus gallus
Domestic chicken
Ggal\RAC2
Gallus gallus
Domestic chicken
Ggal\CDC42
Gallus gallus
Domestic chicken
Ggal\RAC3
Gallus gallus
Domestic chicken
Ggal\RHOG
Gallus gallus
Domestic chicken
Ggal\RHOJ
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026995
Gallus gallus
Domestic chicken
Ggal\RAC1
Gallus gallus
Domestic chicken
Ggal\RHOQ
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Mtl
6 of 10
Rac1
6 of 10
Rac2
6 of 10
RhoU
3 of 10
Rho1
2 of 10
RhoBTB
2 of 10
RhoL
2 of 10
Miro
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Cdc421
model of  cancer
CEA with Ras85DV12.UAS
(Pagliarini and Xu, 2003)
Cdc42JF02855
model of  kidney disease
CEA
(Zhang et al., 2013)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CDC42; cell division cycle 42
14 of 15
116952
     
    RAC1; Rac family small GTPase 1
    3 of 15
    602048
     
    RAC2; Rac family small GTPase 2
    3 of 15
    602049
       
      RAC3; Rac family small GTPase 3
      3 of 15
      602050
        RHOJ; ras homolog family member J
        3 of 15
        607653
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Cdc42 - Abi
            pull down, western blot
            (Fricke et al., 2009)
            Cdc42 - CG12299
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            Cdc42 - Cip4
            pull down, anti tag western blot, western blot, autoradiography, two hybrid
            (Brinkmann et al., 2016, Nahm et al., 2010, Fricke et al., 2009, Leibfried et al., 2008)
            Cdc42 - Frl
            pull down, autoradiography
            (Dollar et al., 2016)
            Cdc42 - GEFmeso
            enzymatic study, pull down, autoradiography
            (Sundaram, 2015, Blanke and Jackle, 2006)
            Cdc42 - Pak
            pull down, autoradiography, western blot
            (Nahm et al., 2006, Harden et al., 1996)
            Cdc42 - Pak3
            anti tag coimmunoprecipitation, western blot
            (Mentzel and Raabe, 2005)
            Cdc42 - RhoGAP100F
            enzymatic study, fluorescence technology, pull down, anti tag western blot
            (Spinner et al., 2018)
            Cdc42 - RhoGAP18B
            anti tag coimmunoprecipitation, anti tag western blot
            (Ojelade et al., 2015)
            Cdc42 - RhoGAP92B
            anti tag coimmunoprecipitation, anti tag western blot
            (Neisch et al., 2013)
            Cdc42 - RhoGEF2
            pull down, autoradiography
            (Nakamura et al., 2017)
            Cdc42 - SCAR
            pull down, western blot
            (Fricke et al., 2009)
            Cdc42 - WASp
            pull down, autoradiography, fluorescent resonance energy transfer, fluorescence microscopy, western blot, enzymatic study, anti tag western blot
            (Sharifai et al., 2014, Nahm et al., 2010, Fricke et al., 2009, Liu et al., 2009, Rodal et al., 2008)
            Cdc42 - Whamy
            pull down, autoradiography, anti tag western blot
            (Brinkmann et al., 2016, Liu et al., 2009)
            Cdc42 - aPKC
            anti bait coimmunoprecipitation, western blot
            (Leibfried et al., 2013)
            Cdc42 - dsx
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            Cdc42 - gek
            pull down, autoradiography, two hybrid
            (Luo et al., 1997)
            Cdc42 - mbt
            anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
            (Melzer et al., 2013, Schneeberger and Raabe, 2003)
            Cdc42 - nwk
            enzymatic study
            (Rodal et al., 2008)
            Cdc42 - par-6
            nuclear magnetic resonance, pull down, western blot, autoradiography, molecular weight estimation by coomasie staining
            (Nunes de Almeida et al., 2019, Atwood et al., 2007, Hutterer et al., 2004, Peterson et al., 2004)
            Cdc42 - pbl
            pull down, autoradiography, anti tag western blot
            (Nakamura et al., 2017, Rosa et al., 2015)
            Cdc42 - slpr
            pull down, autoradiography, anti tag coimmunoprecipitation, western blot
            (Garlena et al., 2010, Neisch et al., 2010)
            Cdc42 - smt3
            pull down, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
            (Handu et al., 2015)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cdc42
            suppressible
            Ack
            (Sem et al., 2002)
            Cdc42
            enhanceable
            bchs
            (Raymond et al., 2004)
            Cdc42
            enhanceable
            bol
            (Zhu et al., 2005)
            Cdc42
            enhanceable
            C3G
            (Raymond et al., 2004)
            Cdc42
            enhanceable
            CG7231
            (Zhu et al., 2005)
            Cdc42
            suppressible
            CG10082
            (Zhu et al., 2005)
            Cdc42
            suppressible
            chic
            (Fritz and VanBerkum, 2002)
            Cdc42
            enhanceable
            Cip4
            (Nahm et al., 2010)
            Cdc42
            enhanceable
            Cip4|WASp
            (Nahm et al., 2010)
            Cdc42
            enhanceable
            dco
            (Zhu et al., 2005)
            Cdc42
            enhanceable
            Eip78C
            (Zhu et al., 2005)
            Cdc42
            suppressible
            fra
            (Dorsten et al., 2007)
            Cdc42
            enhanceable
            Frl
            (Dollar et al., 2016)
            Cdc42
            suppressible
            Frl
            (Dollar et al., 2016)
            Cdc42
            enhanceable
            grp
            (Raymond et al., 2004)
            Cdc42
            enhanceable
            lilli
            (Zhu et al., 2005)
            Cdc42
            enhanceable
            muc
            (Raymond et al., 2004)
            Cdc42
            enhanceable
            N
            (Baron et al., 2000)
            Cdc42
            enhanceable
            NFAT
            (Zhu et al., 2005)
            Cdc42
            suppressible
            numb
            (Raymond et al., 2004)
            Cdc42
            enhanceable
            nwk
            (Rodal et al., 2008)
            Cdc42
            enhanceable
            pbl
            (Raymond et al., 2004)
            Cdc42
            suppressible
            poe
            (Raymond et al., 2004)
            Cdc42
            enhanceable
            Tao
            (Zhu et al., 2005)
            Cdc42
            enhanceable
            Tlk
            (Zhu et al., 2005)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            bnl
            suppressible
            Cdc42
            (Wolf et al., 2002)
            btl
            suppressible
            Cdc42
            (Mukherjee et al., 2012)
            Cip4
            enhanceable
            Cdc42|WASp
            (Nahm et al., 2010)
            Cip4
            enhanceable
            Cdc42
            (Nahm et al., 2010)
            CycB
            suppressible
            Cdc42
            (Ji et al., 2002)
            exp
            suppressible
            Cdc42
            (Iordanou et al., 2014)
            Frl
            suppressible
            Cdc42
            (Dollar et al., 2016)
            Frl
            enhanceable
            Cdc42
            (Dollar et al., 2016)
            kermit
            enhanceable
            Cdc42
            (Djiane and Mlodzik, 2010)
            LIMK1
            suppressible
            Cdc42
            (Ng and Luo, 2004)
            msn
            enhanceable
            Cdc42
            (Ruan et al., 2002)
            Mtl
            enhanceable
            Cdc42
            (Muñoz-Descalzo et al., 2007)
            Mtl
            suppressible
            Cdc42
            (Muñoz-Descalzo et al., 2007)
            Mtl|Rac1|Rac2
            enhanceable
            Cdc42
            (Muñoz-Descalzo et al., 2007)
            ninaE
            suppressible
            Cdc42
            (Chang and Ready, 2000)
            nwk
            suppressible
            Cdc42
            (Rodal et al., 2008)
            nwk
            enhanceable
            Cdc42
            (Rodal et al., 2008)
            Pak
            suppressible
            Cdc42
            (Ng and Luo, 2004)
            pbl
            suppressible
            Cdc42
            (Murray et al., 2012)
            Pvr
            enhanceable
            Cdc42
            (Ishimaru et al., 2004)
            Ras85D
            enhanceable
            Cdc42
            (Pagliarini and Xu, 2003)
            Rho1
            suppressible
            Cdc42
            (Warner and Longmore, 2009)
            robo1
            suppressible
            Cdc42
            (Fritz and VanBerkum, 2002)
            Sos
            enhanceable
            Cdc42
            (Fritz and VanBerkum, 2002)
            ssh
            suppressible
            Cdc42
            (Ng and Luo, 2004)
            tkv
            suppressible
            Cdc42
            (Ricos et al., 1999)
            trc
            enhanceable
            Cdc42
            (He et al., 2005)
            tum
            suppressible
            Cdc42
            (Sotillos and Campuzano, 2000)
            WASp
            enhanceable
            Cdc42|Cip4
            (Nahm et al., 2010)
            WASp
            enhanceable
            Cdc42
            (Nahm et al., 2010)
            Zir
            suppressible
            Cdc42
            (Sampson et al., 2012)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).
            (UniProt, P40793 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
            PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
            Metabolic Pathways
            External Data
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map

            1-64

            Cytogenetic map
            18E1-18E1
            Sequence location
            X:19,697,091..19,699,938 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            18E1-18E1
            Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            18E-18E
            (determined by in situ hybridisation)
            (Sasamura et al., 1997)
            18D-18D
            (determined by in situ hybridisation)
            (Sasamura, 1995)
            Experimentally Determined Recombination Data
            Location

            1-64

            (FlyBase, 2016)

            1-62.4

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (30)
            Genomic Clones (9)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (187)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of
            Additional comments

            The Rac2 gene may have been derived from the Cdc42 gene by retroposition.

            (Dai et al., 2006)
            Other Comments

            S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

            (Stroschein-Stevenson et al., 2006)

            Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

            (Agaisse et al., 2005)

            Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

            (Philips et al., 2005)

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)

            RNAi generated by PCR using primers directed to this gene causes a cell shape change from round to polarized when assayed in Kc167 cells, with the formation of F-actin puncta and microtubule extensions. For both Kc167 and S2R+ cells, reduced F-actin and altered cell shape occur.

            (Kiger et al., 2003)

            dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

            (Rogers et al., 2003)

            Cdc42 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.

            (Fritz and VanBerkum, 2002)

            Cdc42 is necessary for cellular extenion formation, but not for actin cable formation during wound healing in the embryo.

            (Wood et al., 2002)

            Cdc42 may be a negative regulator of N signalling.

            (Baron et al., 2000)

            Cdc42 has a role in actin filament assembly and plays a role on intercellular interactions between the germ-line and the somatic follicle cells.

            (Genova et al., 2000)

            Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.

            (Agnes et al., 1999)

            Cdc42 has a function in dendritic development.

            (Gao et al., 1999)

            ISNb growth cones require Cdc42 for extension to appropriate targets.

            (Kaufmann et al., 1998)

            Cdc42 is not allelic to btdl.

            (Fehon et al., 1997)

            Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.

            (Glise and Noselli, 1997)

            Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.

            (Murphy and Montell, 1996)

            Comparison of expression of constitutively active or dominantly negative Cdc42 and Rac1 mutants demonstrates that similar GTPases in the same subfamily have unique roles in morphogenesis in vivo.

            (Luo et al., 1994)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 78 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (18)
            Reported As
            Symbol Synonym
            CDC-42
            (Jouette et al., 2017)
            CDC42
            (Sundaram, 2015, Wang et al., 2014, Margolis and Borg, 2005, Mirey et al., 2003, Pastor-Pareja et al., 2001, Schejter et al., 2001, Mushegian et al., 1998, O'Leary et al., 1998, Barrett et al., 1997, Eaton, 1997, Eaton, 1997, Tanaka and Sabry, 1995, Harden et al., 1993)
            CG12530
            (Meadows, 2017.1.11, Schertel et al., 2013, Christis and Munro, 2012, Howell et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Li et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Derré et al., 2007, Dai et al., 2006, Colicelli, 2004, Rogers et al., 2003)
            Cdc-42
            (Lang and Munro, 2017)
            Cdc42
            (Boucher et al., 2019, Chen et al., 2019, Franco and Carmena, 2019, Gao et al., 2019, Guan et al., 2019, Jantrapirom et al., 2019, Kono et al., 2019, Nunes de Almeida et al., 2019, Silver et al., 2019, Akishina et al., 2018, Carmena, 2018, Garrido-Jimenez et al., 2018, Medina, 2018, Saito et al., 2018, Schmidt and Grosshans, 2018, Spinner et al., 2018, Tsai et al., 2018, Akishina et al., 2017, Banisch et al., 2017, Colombié et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Koch et al., 2017, Lou et al., 2017, Nakamura et al., 2017, Ozasa et al., 2017, Park et al., 2017, Siddall and Hime, 2017, Ajduk and Zernicka-Goetz, 2016, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Dollar et al., 2016, Fear et al., 2016, Matsubayashi and Millard, 2016, Meehan et al., 2016, Roman-Fernandez and Bryant, 2016, Sarov et al., 2016, Schimizzi et al., 2016, Whitney et al., 2016, Flores-Benitez and Knust, 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rosa et al., 2015, Verboon and Parkhurst, 2015, Verboon et al., 2015, Vlisidou and Wood, 2015, Abreu-Blanco et al., 2014, Iordanou et al., 2014, Jones et al., 2014, Lammel et al., 2014, Pichaud, 2014, Sailem et al., 2014, Sharifai et al., 2014, Swope et al., 2014, Yashiro et al., 2014, Beckett et al., 2013, Bergstralh et al., 2013, Chen et al., 2013, Leibfried et al., 2013, Melzer et al., 2013, Muha and Müller, 2013, Neisch et al., 2013, Puram and Bonni, 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Zhang et al., 2013, Zhu, 2013, Abreu-Blanco et al., 2012, Baek et al., 2012, Fabian and Brill, 2012, Gates, 2012, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Murray et al., 2012, Peltan et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Tepass, 2012, Tsubouchi et al., 2012, Zoller and Schulz, 2012, Fauvarque and Williams, 2011, Gontang et al., 2011, Jones and Metzstein, 2011, Laprise and Tepass, 2011, Meiklejohn et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Pilgram et al., 2011, Qian et al., 2011, Razzell et al., 2011, Rotkopf et al., 2011, Song and Giniger, 2011, Tanaka et al., 2011, Zhang et al., 2011, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, Colosimo et al., 2010, D'Ambrosio and Vale, 2010, Dorsten et al., 2010, Elsaesser et al., 2010, Garlena et al., 2010, Georgiou and Baum, 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Quinones et al., 2010, Robinson et al., 2010, Sato et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Venken et al., 2010, Walther and Pichaud, 2010, Warner, 2010.9.15, Warner et al., 2010, Asano et al., 2009, Frank et al., 2009, Fricke et al., 2009, Gupta et al., 2009, Hirano et al., 2009, Kamiyama and Chiba, 2009, Liu et al., 2009, Patch et al., 2009, van Impel et al., 2009, Warner and Cook, 2009.11.19, Warner and Longmore, 2009, Warner and Longmore, 2009, Bakal et al., 2008, Harris and Tepass, 2008, Harris and Tepass, 2008, Kim et al., 2008, Larson et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Rodal et al., 2008, Vogler et al., 2008, Warren-Paquin et al., 2008, Zhou et al., 2008, Atwood et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beltran et al., 2007, Colinet et al., 2007, Derré et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Jovceva et al., 2007, Leibfried et al., 2007, Muñoz-Descalzo et al., 2007, Taniguchi et al., 2007, Tepass and Harris, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Hozumi et al., 2006, Humbert et al., 2006, Kerkhoff, 2006, Nahm et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Talbot and VanBerkum, 2006, Avet-Rochex et al., 2005, Cho et al., 2005, Go, 2005, Sen et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hofmann et al., 2004, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Gao and Bogert, 2003, Rogers et al., 2003, Kim et al., 2002, Wolf et al., 2002)
            Cdc42Dm
            (Zhang et al., 1999)
            D-CDC42
            (Ip and Davis, 1998)
            D-Cdc42
            (Knust, 1997)
            D-cdc42
            (Ryabinina et al., 2006)
            DCDC42
            (Hummel et al., 2000, Sasamura et al., 1995)
            DCdc42
            (Blanke and Jackle, 2006, Van Aelst and Symons, 2002, Dobens et al., 2001, Dobens et al., 2000, Paladi and Tepass, 2000, Sotillos and Campuzano, 2000, Szuts and Bienz, 2000, Hacker and Perrimon, 1998, Martin-Blanco, 1997, Van Aelst and D'Souza-Schorey, 1997)
            Dcdc42
            (Shuai et al., 2010, Dorsten et al., 2007, He et al., 2005, Xia and Karin, 2004, He and Adler, 2003, Vasenkova et al., 2003, Adler, 2002, Harden et al., 2002, He and Adler, 2002, Kim et al., 2002, Noselli, 2002, Sem et al., 2002, Zahedi et al., 2002, Dawber et al., 2001, Harden et al., 2001, Luginbuhl et al., 2001, Raymond et al., 2001, Raymond et al., 2001, Suzanne et al., 2001, Zarske et al., 2001, Allen et al., 2000, Baron et al., 2000, Benlali et al., 2000, Dobens and Raftery, 2000, Jacobs et al., 2000, Kim and Chiba, 2000, Muller, 2000, Raymond et al., 2000, Agnes and Noselli, 1999, Agnes and Noselli, 1999, Agnes et al., 1999, Gao et al., 1999, Harden et al., 1999, Harden et al., 1999, Noselli and Agnes, 1999, Paululat et al., 1999, Ricos et al., 1999, Ricos et al., 1999, Stronach and Perrimon, 1999, Goberdhan and Wilson, 1998, Noselli, 1998, Zohn et al., 1998, Luo et al., 1997, Sasamura et al., 1997, Sone et al., 1997, Eaton et al., 1995, Luo et al., 1995, Luo, 1994.7.5, Luo et al., 1994)
            Dm Cdc42
            (Jekely, 2003)
            DmCDC42
            (Mentzel and Raabe, 2005, Piekny et al., 2005)
            Dmcdc42
            (Riesgo-Escovar et al., 1996)
            P40793
            (Rojas et al., 2012)
            cdc42
            (Barr et al., 2019, Hao and Jin, 2017, Liu et al., 2016, Ruan et al., 2016, Hosono et al., 2015, Kamiyama et al., 2015, Ugrankar et al., 2015, Jalvingh et al., 2014, Pereira et al., 2014, Bergstralh et al., 2013, Cook et al., 2012, Fletcher et al., 2012, Mukherjee et al., 2012, Miles et al., 2011, Ohsawa et al., 2011, Chang et al., 2010, Djiane and Mlodzik, 2010, Nahm et al., 2010, Higuchi et al., 2009, Kamiyama and Chiba, 2009, Qian and Bodmer, 2009, van Impel et al., 2009, Georgiou et al., 2008, Leibfried et al., 2008, Llense and Martín-Blanco, 2008, McGraw et al., 2008, Rodal et al., 2008, Atwood et al., 2007, Avet-Rochex et al., 2007, Schafer et al., 2007, Huelsmann et al., 2006, Houalla et al., 2005, Leptin, 2005, Zhu et al., 2005, Ng and Luo, 2004, Polesello and Payre, 2004, Pagliarini and Xu, 2003, Rogers et al., 2003, Mlodzik, 2002, Pandur et al., 2002, Ruan et al., 2002, Jhaveri and Rodrigues, 2001, Kadam and Reuter, 2001, Sepp and Auld, 2001, Schock and Perrimon, 2000, Asha et al., 1999, Nairz and Hafen, 1999, Prokopenko et al., 1999, Sawamoto et al., 1999, Sawamoto et al., 1999, Boutros et al., 1998, Matova et al., 1998, Nolan et al., 1998, Matova et al., 1997, Murphy and Montell, 1995)
            Name Synonyms
            Cdc42
            (Frank, 2014, Melzer et al., 2013, Cammarato et al., 2011, Robinson et al., 2010, Patch et al., 2009, Zhou et al., 2008, Wolf et al., 2002)
            Cdc42-like
            Secondary FlyBase IDs
            • FBgn0012059
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (528)