FlyBase Gene Report: Dmel\Cds

General Information

Symbol

Dmel\Cds

Species

D. melanogaster

Name

CDP-diacylglycerol synthase

Annotation Symbol

CG7962

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010350

Gene Model Status

Stock Availability

13 publicly available

Gene Snapshot

CDP-diacylglycerol synthase (Cds) encodes an enzyme for the synthesis of cytidine diphosphate diacylglycerol (CDP-DAG) from phosphatidic acid. CDP-DAG is the precursor of two phospholipids, phosphatidylinositol and phosphatidylglycerol. The product of Cds has roles in cell growth and lipid storage. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

CdsA, CDP diglyceride synthetase, eye-CDS, CDP-diacylglycerol synthetase, winded

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:8,127,762..8,131,675 [+]

Recombination map

3-22

RefSeq locus

NT_037436 REGION:8127762..8131675

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables phosphatidate cytidylyltransferase activity

inferred from direct assay

(Wang and Montell, 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables phosphatidate cytidylyltransferase activity

inferred from sequence or structural similarity

(Wu et al., 1995)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in lipid biosynthetic process

inferred from mutant phenotype

(Laurinyecz et al., 2016)

involved_in negative regulation of triglyceride biosynthetic process

inferred from mutant phenotype

(Liu et al., 2014)

involved_in phototransduction

inferred from mutant phenotype

(Wu et al., 1995)

inferred from genetic interaction with FLYBASE:Arr2; FB:FBgn0000121

(Wu et al., 1995)

involved_in positive regulation of phosphatidylinositol biosynthetic process

inferred from mutant phenotype

(Liu et al., 2014)

involved_in regulation of lipid storage

inferred from mutant phenotype

(Tian et al., 2011)

involved_in rhodopsin mediated signaling pathway

inferred from mutant phenotype

(Zuker, 1996)

involved_in sperm individualization

inferred from mutant phenotype

(Laurinyecz et al., 2016)

involved_in terminal branching, open tracheal system

inferred from high throughput mutant phenotype

(Ghabrial et al., 2011)

involved_in thermotaxis

inferred from direct assay

(Kwon et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in CDP-diacylglycerol biosynthetic process

non-traceable author statement

(Montell, 1999)

involved_in phototransduction

non-traceable author statement

(Hardie, 2001, Montell, 1999)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN000349519

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES

Protein Family (UniProt)

Belongs to the CDS family. (P56079)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES -: Cytidylyltransferases catalyse the transfer of a cytidylyl group to an acceptor.

Protein Function (UniProtKB)

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:7816135, PubMed:24603715). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135). In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715). Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715). This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715). Required for spermatid individualization by regulating lipid compositions and lipid-mediated signaling during spermatogenesis (PubMed:26791243).

(UniProt, P56079)

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Cds for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0076688

2391

447

FBtr0346546

2609

447

Additional Transcript Data and Comments

Reported size (kB)

2.5 (northern blot)

(Wu et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0076411

51.5

447

7.42

FBpp0312164

51.5

447

7.42

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

447 aa isoforms: Cds-PA, Cds-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

447 (aa); 49 (kD observed)

(Wu et al., 1995)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cds using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

(Xu et al., 2004)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

photoreceptor cell R1 -- photoreceptor cell R8

(Wu et al., 1995)

(Wu et al., 1995)

(Wu et al., 1995)

Additional Descriptive Data

Cds protein is expressed in fly heads but not bodies. In frozen sections of adult heads, Cds protein is localized to the photoreceptor cell neurons both in the eye and in the ocelli.

(Wu et al., 1995)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{HZ}Cds¹

Stage

Tissue/Position (including subcellular localization)

Reference

photoreceptor cell R1 -- photoreceptor cell R8

(Wu et al., 1995)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cds in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cds

View exonic expression by tissue for Dmel\Cds

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010350

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010350

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7962-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7962

Flygut - An atlas of the Drosophila adult midgut

FBgn0010350

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cds

Stages(s) 1-3
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cds

Transgenic constructs containing regulatory region of Cds

Deletions and Duplications ( 2 )

Disrupted in

(Ryder, 2004.4.26)

(Ghabrial et al., 2011)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Cds⁷

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cds^GD2357

Cds¹

viable, with Scer\GAL4^Mef2.PR

Cds^GD2357

viable, with Scer\GAL4^pnr-MD237

Cds^GD2357

viable, with Scer\GAL4^tin.CΔ4

Cds^GD2357

Sterility

Allele

male sterile (with Df(3L)BSC795)

Other Phenotypes

Allele

decreased cell size

Cds^GS8005

decreased cell size, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

majority die during larval stage

Cds^GS8005

neurophysiology defective

Cds¹

some die during embryonic stage

Cds^GS8005

thermotaxis defective

Cds¹

visual behavior defective

Cds¹

Phenotype manifest in

Allele

brain, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

Cds^UM-8246-3

embryonic/larval fat body, with Scer\GAL4^ppl.PP

Cds^NIG.7962R

embryonic/larval fat body, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

embryonic/larval salivary gland

Cds¹

embryonic/larval salivary gland, with Scer\GAL4^ppl.PP

Cds^EY08412

embryonic/larval salivary gland | cell autonomous | somatic clone

Cds^GS8005

embryonic/larval tracheal system

eye | somatic clone

eye photoreceptor cell

Cds¹

imaginal disc, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

lipid droplet | ectopic

Cds¹

lipid droplet | ectopic, with Scer\GAL4^elav.PU

Cds^NIG.7962R

lipid droplet | ectopic, with Scer\GAL4^ppl.PP

Cds^NIG.7962R

major mitochondrial derivative

Cds^CB-0128-3

minor mitochondrial derivative

Cds^CB-0128-3

Cds¹

photoreceptor cell

Cds¹

photoreceptor cell R1

Cds¹

photoreceptor cell R2

Cds¹

photoreceptor cell R3

Cds¹

photoreceptor cell R4

Cds¹

photoreceptor cell R5

Cds¹

photoreceptor cell R6

Cds¹

photoreceptor cell R7

Cds¹

photoreceptor cell R8

Cds¹

Cds¹

Cds¹

salivary gland, with Scer\GAL4^elav.PU

Cds^NIG.7962R

salivary gland, with Scer\GAL4^ppl.PP

Cds^NIG.7962R

spermatid axoneme

Cds^CB-0128-3

Cds^CB-0128-3

terminal tracheal cell

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

12 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

12 of 15

No

Yes

Rattus norvegicus (Norway rat) (2)

12 of 13

Yes

Yes

10 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (2)

8 of 12

Yes

Yes

7 of 12

No

Yes

Danio rerio (Zebrafish) (2)

10 of 15

Yes

Yes

8 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

15 of 15

Yes

Yes

Arabidopsis thaliana (thale-cress) (5)

9 of 9

Yes

Yes

8 of 9

No

Yes

7 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

14 of 15

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC13A2.03

11 of 12

Yes

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909D7 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00003692

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504J8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY012029

Mayetiola destructor

Hessian fly

Mdes\Mdes003038

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001940

Anopheles darlingi

American malaria mosquito

Adar\ADAC008771

Anopheles gambiae

Malaria mosquito

Agam\AGAP007175

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009904

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04RD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012695

Bombyx mori

Silkmoth

Bmor\BGIBMGA012694

Danaus plexippus

Monarch butterfly

Dple\DPOGS210056-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007413

Apis florea

Little honeybee

Aflo\2239999764

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0002bb

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013258

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM601700

Rhodnius prolixus

Kissing bug

Rpro\RPRC011566

Cimex lectularius

Bed bug

Clec\CLEC007774

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004171

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06471

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04NQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013088

Ixodes scapularis

Black-legged tick

Isca\ISCW022031

Ixodes scapularis

Black-legged tick

Isca\ISCW022033

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66235.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66236.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur20g01750

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_315618

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06CA )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\LOC100183841

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

exacerbates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

exacerbates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

ameliorates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDS1; CDP-diacylglycerol synthase 1

13 of 15

CDS2; CDP-diacylglycerol synthase 2

12 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2014)

enhanceable

(Raghu et al., 2009)

enhanceable

(Liu et al., 2014)

enhanceable

(Raghu et al., 2009)

suppressible

(Liu et al., 2014)

suppressible

(Laurinyecz et al., 2016, Wang and Montell, 2006)

enhanceable

(Garcia-Murillas et al., 2006)

enhanceable

(Tian et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Raghu et al., 2009)

enhanceable

(Raghu et al., 2009)

suppressible

(Laviolette et al., 2005)

suppressible

(Liu et al., 2014)

enhanceable

(Garcia-Murillas et al., 2006)

suppressible

(Tian et al., 2011)

enhanceable

(Tian et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68739

DroID - A comprehensive database of gene and protein interactions.

FBgn0010350

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43950

MIST (genetic) - An integrated Molecular Interaction Database

CdsA

MIST (protein-protein) - An integrated Molecular Interaction Database

CdsA

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-22

Cytogenetic map

Sequence location

3L:8,127,762..8,131,675 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66B7-66B7

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66B-66B

(determined by in situ hybridisation)

(Wu et al., 1995)

Location based on deficiency mapping with Df(3L)pbl-X1.

(Ghabrial et al., 2011)

Experimentally Determined Recombination Data

Location

3-22

(FlyBase, 2016)

3-19.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

28075

y¹ v¹; P{TRiP.JF02912}attP2

58118

y¹ v¹; P{TRiP.HMJ22055}attP40

16893

y¹ w^67c23; P{EPgy2}Cds^EY08412

63089

w^*; P{GAL4-btl.S}2, P{UASp-Act5C.T:GFP}2; Cds¹²²⁷ P{FRT(w^hs)}2A P{neoFRT}82B/TM3, P{tubP-GAL80}3, Sb¹

123043

w¹¹¹⁸; P{RS3}Cds^CB-0128-3

124442

w¹¹¹⁸; P{RS3}Cds^UM-8246-3

112133

y^* w^*; P{GawB}Cds^NP0318

103768

w^*; P{GawB}Cds^NP0802 / TM3, Ser¹

200770

w^*; P{GSV2}Cds^GS5189/TM3, Sb¹ Ser¹

201308

y¹ w^67c23; P{GSV3}Cds^GS8005/TM3, Sb¹ Ser¹

v103415

P{KK100637}VIE-260B

v5121

w¹¹¹⁸; P{GD2357}v5121

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (90)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH66092

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010350

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010350

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43950

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wu et al., 1995)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CdsA winded

(Ghabrial, 2005.3.2)

Source for identity of: Cds CdsA

(FlyBase, 2009-)

Source for database merge of

Source for merge of: CdsA CG7962

(Whitfield, 2000.10.30)

Additional comments

Other Comments

CdsA diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol synthesis and coordinates cell growth and fat storage.

(Liu et al., 2014)

May be required for tracheal terminal cell growth and branching.

(Ghabrial et al., 2005)

A step in the resynthesis of phosphatidylinositol-4,5-biphosphate, PtdInsP₂ (needed for signal transduction), is performed by CDP-DAG synthase. CdsA encodes CDP-DAG synthase, an enzyme that activates phosphatidic acid by converting it to CDP-DAG.

(Hurley, 1995)

CdsA protein is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-biphosphate (PtdInsP₂) from phosphatidic acid. A photoreceptor cell isoform of CdsA is a key regulator of phototransduction.

(Wu et al., 1995)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43950

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P56079

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JC55

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010350

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010350

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7962

Flygut - An atlas of the Drosophila adult midgut

FBgn0010350

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43950

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7962

modMine - A data warehouse for the modENCODE project

FBgn0010350

Linkouts

BioGRID - A database of protein and genetic interactions.

68739

DroID - A comprehensive database of gene and protein interactions.

FBgn0010350

DRSC - Results frm RNAi screens

FBgn0010350

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010350

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7962-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010350

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

FlyMine - An integrated database for Drosophila genomics

FBgn0010350

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43950

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

CdsA

MIST (protein-protein) - An integrated Molecular Interaction Database

CdsA

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CDS

(Liu et al., 2014, Hurley, 1995)

CG7962

(Wang et al., 2019, Liu et al., 2018, Cockcroft and Raghu, 2016, Laurinyecz et al., 2016, Hosono et al., 2015, Banerjee et al., 2012, Bridon et al., 2012, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Laviolette et al., 2005)

Cds

(Olson et al., 2019, Yan et al., 2019, Suratekar et al., 2018, Cockcroft and Raghu, 2016)

CdsA

(Yang et al., 2019, Yan et al., 2017, Laurinyecz et al., 2016, Liu et al., 2014, Bridon et al., 2012, Mizrak et al., 2012, Senthilan et al., 2012, Tian et al., 2011, Ranade et al., 2008, Landry et al., 2007, Girardot et al., 2006, Wijnen et al., 2006, Laviolette et al., 2005)

cds

cdsA

(Liu et al., 2018, Ghabrial, 2005.3.2)

eye-CDS

(Acharya et al., 1998, Hurley, 1995)

eye-cds

(Wu et al., 1995)

Name Synonyms

CDP diglyceride synthetase

(Cammarato et al., 2011, Khanna et al., 2010)

CDP-DAG synthase

(Huang et al., 2010, Montell, 1999)

CDP-diacylglycerol synthase

(Wang and Montell, 2006)

CDP-diacylglycerol synthetase

(Liu et al., 2014, Wu et al., 1995)

CDS-diacylglycerol synthase

(Kwon et al., 2008)

cytidine diphosphate (CDP)-DAG synthase

(Raghu et al., 2009)

diacyl-glycerol-synthetase

(Banerjee et al., 2012)

winded

(Ghabrial et al., 2011, Ghabrial et al., 2005)

Secondary FlyBase IDs

FBgn0035841

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (82)