FlyBase Gene Report: Dmel\Cds

General Information

Symbol

Dmel\Cds

Species

D. melanogaster

Name

CDP-diacylglycerol synthase

Annotation Symbol

CG7962

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010350

Gene Model Status

Current

Stock Availability

13 publicly available

Enzyme Name (EC)

Phosphatidate cytidylyltransferase (2.7.7.41)

Gene Snapshot

CDP-diacylglycerol synthase (Cds) encodes an enzyme for the synthesis of cytidine diphosphate diacylglycerol (CDP-DAG) from phosphatidic acid. CDP-DAG is the precursor of two phospholipids, phosphatidylinositol and phosphatidylglycerol. The product of Cds has roles in cell growth and lipid storage. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

CdsA, CDP diglyceride synthetase, eye-CDS, CDP-diacylglycerol synthetase, winded

Key Links

Genomic Location

Cytogenetic map

66B7-66B7

Sequence location

3L:8,127,762..8,131,675 [+]

Recombination map

3-22

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES

Protein Family (UniProt)

Belongs to the CDS family. (P56079)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

phosphatidate cytidylyltransferase activity

Predictions / Assertions

phosphatidate cytidylyltransferase activity

Catalytic Activity (EC)

Experimental Evidence

CTP + phosphatidate = diphosphate + CDP-diacylglycerol (2.7.7.41)

Predictions / Assertions

CTP + phosphatidate = diphosphate + CDP-diacylglycerol (2.7.7.41)

Summaries

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES -: Cytidylyltransferases catalyse the transfer of a cytidylyl group to an acceptor.

Protein Function (UniProtKB)

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:7816135, PubMed:24603715). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135). In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715). Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715). This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715).

(UniProt, P56079)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Cds or the JBrowse view of Dmel\Cds for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cds-RA

FBtr0076688

NM_079922

2391

447

Cds-RB

FBtr0346546

NM_001300047

2609

447

Additional Transcript Data and Comments

Reported size (kB)

2.5 (northern blot)

(Wu et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cds-PA

FBpp0076411

51.5

447

7.42

NP_524661

AAF50483

Cds-PB

FBpp0312164

51.5

447

7.42

NP_001286976

AHN58001

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

447 aa isoforms: Cds-PA, Cds-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

447 (aa); 49 (kD observed)

(Wu et al., 1995)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cds using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

phosphatidate cytidylyltransferase activity

inferred from direct assay

(Wang and Montell, 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

phosphatidate cytidylyltransferase activity

inferred from sequence or structural similarity

(Wu et al., 1995)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

lipid biosynthetic process