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Gene Dmel\βTry

General Information
Symbol	Dmel\βTry	Species	D. melanogaster
Name	βTrypsin	Annotation symbol	CG18211
Feature type	protein_coding_gene	FlyBase ID	FBgn0010357
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47F4-47F4	Sequence location	2R:7,233,840..7,234,641 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene βTrypsin is referred to in FlyBase by the symbol Dmel\βTry (CG18211, FBgn0010357). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: serine-type endopeptidase activity. It is reported to be involved in the biological process: proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S1; Peptidase S1, trypsin family, active site; Peptidase S1A, chymotrypsin-type; Trypsin-like cysteine/serine peptidase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630320_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of betaTry. Gene sequence location is 2R:7233840..7234641.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Try: Trypsin Structural gene for enzyme trypsin.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47F4-47F4   Limits computationally determined from genome sequence between P{lacW}Fppsk06103&P{lacW}Fppsk03514 and P{lacW}Tapδk17005&P{lacW}k05103
Experimentally Determined Cytological Location
Cytogenetic map Notes References 47D-47F     (Magoulas, 1992) 47D-47F   (determined by in situ hybridisation)   (Davis et al., 1985)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\βTry for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Apparent introns not annotated: probable artifact due to repetitive sequence.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) βTry-RA FBtr0088122  NM_080165   802   253
Additional Transcript Data & Comments
Reported size (kB)	0.7 (unknown) (Davis et al., 1985)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein βTry-PA   FBpp0087223   25.7   253   8.66     NP_524904   AAF58658
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1 (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Peptidase S1, trypsin family, active site (IPR018114) Trypsin-like cysteine/serine peptidase domain (IPR009003) MEROPS - An information resource for peptidases and the proteins that inhibit them • S01.112
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58658   AI257890   AI401999   AY071341   AY075487   AY232074   BT016077 AAV36962   BT128808   BT132779   CK131147   CO183530   CO195034   EL872123   EL872248   EL874756   EL874883   EV576053   EV583543   M96372 AAA28980   U04853 AAA17451
UniProtKB/Swiss-Prot	P35004
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval digestive system | restricted   (Davis et al., 1985) Comment:expressed in the gut adult stage     (Davis et al., 1985)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut    5625.4 Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut    6246.5 Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut  (5625.4) Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut  (6246.5) Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut  (5625.4) Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut  (6246.5) Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut    5625.4 Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut    6246.5 Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut    5625.4 Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut    6246.5 Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut  (5625.4) Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut  (6246.5) Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut  (5625.4) Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut  (6246.5) Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4 Larval Midgut    5625.4 Larval Hindgut    34 Larval Malpighian Tubules    4 Larval Fat Body    24.4 Larval Salivary Gland    3.5 Larval Trachea    78.325 Larval Carcass    18.875 Adult Head    109.3 Adult Eye    53.325 Adult Brain    5.4 Adult Thoracic-Abdominal Ganglion    10.8 Adult Crop    50.7 Adult Midgut    6246.5 Adult Hindgut    38.1 Adult Malpighian Tubules    3.2 Adult Fat Body    7.5 Adult Salivary Gland    34.2 Adult Heart    8.7 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    4.9 Adult Testis    29.3 Adult Male Accessory Gland    5.1 Adult Carcass    139.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    5.4   4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   5625.4  Midgut    6246.5   no informative data  Hindgut    38.1   4  Malpighian Tubules    3.2   no informative data  Fat Body    7.5   3.5  Salivary Gland    no informative data   NA  Heart    8.7   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    3.2   NA  InseminatedFemale Spermatheca    5.6   NA  Ovary    4.9   NA  Testis    no informative data   NA  Male Accessory Gland    5.1   no informative data  Carcass    139.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    499 central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    52 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2678 digestive system, 1-day adult    10908 digestive system, 4-day adult    8457 digestive system, 20-day adult    13048 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    28 carcass, larvae L3 wandering    10 carcass, 1-day adult    184 carcass, 4-day adult    137 carcass, 20-day adult    330 ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male    42 accessory gland, mated 4-day male    102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (499) central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (52) salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (2678) digestive system, 1-day adult  (10908) digestive system, 4-day adult  (8457) digestive system, 20-day adult  (13048) fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8  (28) carcass, larvae L3 wandering    10 carcass, 1-day adult  (184) carcass, 4-day adult  (137) carcass, 20-day adult  (330) ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male  (42) accessory gland, mated 4-day male  (102) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (499) central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    52 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (2678) digestive system, 1-day adult  (10908) digestive system, 4-day adult  (8457) digestive system, 20-day adult  (13048) fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    28 carcass, larvae L3 wandering    10 carcass, 1-day adult  (184) carcass, 4-day adult  (137) carcass, 20-day adult  (330) ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male    42 accessory gland, mated 4-day male  102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    499 central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    52 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2678 digestive system, 1-day adult    10908 digestive system, 4-day adult    8457 digestive system, 20-day adult    13048 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    28 carcass, larvae L3 wandering    10 carcass, 1-day adult    184 carcass, 4-day adult    137 carcass, 20-day adult    330 ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male    42 accessory gland, mated 4-day male    102 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    499 central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    52 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2678 digestive system, 1-day adult    10908 digestive system, 4-day adult    8457 digestive system, 20-day adult    13048 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    28 carcass, larvae L3 wandering    10 carcass, 1-day adult    184 carcass, 4-day adult    137 carcass, 20-day adult    330 ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male    42 accessory gland, mated 4-day male    102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (499) central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (52) salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (2678) digestive system, 1-day adult  (10908) digestive system, 4-day adult  (8457) digestive system, 20-day adult  (13048) fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8  28 carcass, larvae L3 wandering    10 carcass, 1-day adult  (184) carcass, 4-day adult  (137) carcass, 20-day adult  (330) ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male  (42) accessory gland, mated 4-day male  (102) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (499) central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    52 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (2678) digestive system, 1-day adult  (10908) digestive system, 4-day adult  (8457) digestive system, 20-day adult  (13048) fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    28 carcass, larvae L3 wandering    10 carcass, 1-day adult  (184) carcass, 4-day adult  137 carcass, 20-day adult  (330) ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male    42 accessory gland, mated 4-day male  102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    499 central nervous system, larvae L3    4 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    19 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    52 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2678 digestive system, 1-day adult    10908 digestive system, 4-day adult    8457 digestive system, 20-day adult    13048 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    28 carcass, larvae L3 wandering    10 carcass, 1-day adult    184 carcass, 4-day adult    137 carcass, 20-day adult    330 ovary, virgin 4-day female    4 ovary, mated 4-day female    1 testis, mated 4-day male    42 accessory gland, mated 4-day male    102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    50 larva L2    147 larva L3 12hr old    83 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    38 white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    392 adult male 05day    915 adult male 30day    396 adult female 01day    483 adult female 05day    492 adult female 30day    498 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1  (50) larva L2  (147) larva L3 12hr old  (83) larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (109) larva L3 puffstage 7-9  (38) white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day  (392) adult male 05day  (915) adult male 30day  (396) adult female 01day  (483) adult female 05day  (492) adult female 30day  (498) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    50 larva L2  (147) larva L3 12hr old    83 larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (109) larva L3 puffstage 7-9    38 white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day  (392) adult male 05day  (915) adult male 30day  (396) adult female 01day  (483) adult female 05day  (492) adult female 30day  (498) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    50 larva L2    147 larva L3 12hr old    83 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    38 white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    392 adult male 05day    915 adult male 30day    396 adult female 01day    483 adult female 05day    492 adult female 30day    498 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    50 larva L2    147 larva L3 12hr old    83 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    38 white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    392 adult male 05day    915 adult male 30day    396 adult female 01day    483 adult female 05day    492 adult female 30day    498 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1  (50) larva L2  (147) larva L3 12hr old  (83) larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (109) larva L3 puffstage 7-9  (38) white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day  (392) adult male 05day  (915) adult male 30day  (396) adult female 01day  (483) adult female 05day  (492) adult female 30day  (498) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    50 larva L2  (147) larva L3 12hr old    83 larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  109 larva L3 puffstage 7-9    38 white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day  (392) adult male 05day  (915) adult male 30day  (396) adult female 01day  (483) adult female 05day  (492) adult female 30day  (498) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    50 larva L2    147 larva L3 12hr old    83 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    38 white prepupae new    5 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    392 adult male 05day    915 adult male 30day    396 adult female 01day    483 adult female 05day    492 adult female 30day    498 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    791 cold shock, 4-day adult    834 heat shock, 4-day adult    1172 Cadmium 50 mM 6 hrs, larvae L3    1591 Cadmium 50 mM 12 hrs, larvae L3    890 Cadmium 50 mM 48 hrs, 4-day adult    998 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    424 Copper 15 mM 48 hrs, 4-day adult    60 Zinc 5 mM 12 hrs, larvae L3    501 Zinc 4.5 mM 48 hrs, 4-day adult    436 Ethanol 2.5% 3 hrs, larvae L3    342 Ethanol 5% 3 hrs, larvae L3    1480 Ethanol 10% 3 hrs, larvae L3    1639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1576 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    310 Caffeine 25 mg/ml 48 hrs, 4-day adult    644 Paraquat 5 mM 48 hrs, 4-day adult    1008 Paraquat 10 mM 48 hrs, 4-day adult    1949 Rotenone 2 μg 12 hrs, larvae L3    2207 Rotenone 8 μg 12 hrs, larvae L3    2235 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (791) cold shock, 4-day adult  (834) heat shock, 4-day adult  (1172) Cadmium 50 mM 6 hrs, larvae L3  (1591) Cadmium 50 mM 12 hrs, larvae L3  (890) Cadmium 50 mM 48 hrs, 4-day adult  (998) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (424) Copper 15 mM 48 hrs, 4-day adult  (60) Zinc 5 mM 12 hrs, larvae L3  (501) Zinc 4.5 mM 48 hrs, 4-day adult  (436) Ethanol 2.5% 3 hrs, larvae L3  (342) Ethanol 5% 3 hrs, larvae L3  (1480) Ethanol 10% 3 hrs, larvae L3  (1639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1576) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (310) Caffeine 25 mg/ml 48 hrs, 4-day adult  (644) Paraquat 5 mM 48 hrs, 4-day adult  (1008) Paraquat 10 mM 48 hrs, 4-day adult  (1949) Rotenone 2 μg 12 hrs, larvae L3  (2207) Rotenone 8 μg 12 hrs, larvae L3  (2235) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (791) cold shock, 4-day adult  (834) heat shock, 4-day adult  (1172) Cadmium 50 mM 6 hrs, larvae L3  (1591) Cadmium 50 mM 12 hrs, larvae L3  (890) Cadmium 50 mM 48 hrs, 4-day adult  (998) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (424) Copper 15 mM 48 hrs, 4-day adult    60 Zinc 5 mM 12 hrs, larvae L3  (501) Zinc 4.5 mM 48 hrs, 4-day adult  (436) Ethanol 2.5% 3 hrs, larvae L3  (342) Ethanol 5% 3 hrs, larvae L3  (1480) Ethanol 10% 3 hrs, larvae L3  (1639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1576) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (310) Caffeine 25 mg/ml 48 hrs, 4-day adult  (644) Paraquat 5 mM 48 hrs, 4-day adult  (1008) Paraquat 10 mM 48 hrs, 4-day adult  (1949) Rotenone 2 μg 12 hrs, larvae L3  (2207) Rotenone 8 μg 12 hrs, larvae L3  (2235) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    791 cold shock, 4-day adult    834 heat shock, 4-day adult    1172 Cadmium 50 mM 6 hrs, larvae L3    1591 Cadmium 50 mM 12 hrs, larvae L3    890 Cadmium 50 mM 48 hrs, 4-day adult    998 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    424 Copper 15 mM 48 hrs, 4-day adult    60 Zinc 5 mM 12 hrs, larvae L3    501 Zinc 4.5 mM 48 hrs, 4-day adult    436 Ethanol 2.5% 3 hrs, larvae L3    342 Ethanol 5% 3 hrs, larvae L3    1480 Ethanol 10% 3 hrs, larvae L3    1639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1576 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    310 Caffeine 25 mg/ml 48 hrs, 4-day adult    644 Paraquat 5 mM 48 hrs, 4-day adult    1008 Paraquat 10 mM 48 hrs, 4-day adult    1949 Rotenone 2 μg 12 hrs, larvae L3    2207 Rotenone 8 μg 12 hrs, larvae L3    2235 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    791 cold shock, 4-day adult    834 heat shock, 4-day adult    1172 Cadmium 50 mM 6 hrs, larvae L3    1591 Cadmium 50 mM 12 hrs, larvae L3    890 Cadmium 50 mM 48 hrs, 4-day adult    998 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    424 Copper 15 mM 48 hrs, 4-day adult    60 Zinc 5 mM 12 hrs, larvae L3    501 Zinc 4.5 mM 48 hrs, 4-day adult    436 Ethanol 2.5% 3 hrs, larvae L3    342 Ethanol 5% 3 hrs, larvae L3    1480 Ethanol 10% 3 hrs, larvae L3    1639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1576 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    310 Caffeine 25 mg/ml 48 hrs, 4-day adult    644 Paraquat 5 mM 48 hrs, 4-day adult    1008 Paraquat 10 mM 48 hrs, 4-day adult    1949 Rotenone 2 μg 12 hrs, larvae L3    2207 Rotenone 8 μg 12 hrs, larvae L3    2235 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (791) cold shock, 4-day adult  (834) heat shock, 4-day adult  (1172) Cadmium 50 mM 6 hrs, larvae L3  (1591) Cadmium 50 mM 12 hrs, larvae L3  (890) Cadmium 50 mM 48 hrs, 4-day adult  (998) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (424) Copper 15 mM 48 hrs, 4-day adult  (60) Zinc 5 mM 12 hrs, larvae L3  (501) Zinc 4.5 mM 48 hrs, 4-day adult  (436) Ethanol 2.5% 3 hrs, larvae L3  (342) Ethanol 5% 3 hrs, larvae L3  (1480) Ethanol 10% 3 hrs, larvae L3  (1639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1576) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (310) Caffeine 25 mg/ml 48 hrs, 4-day adult  (644) Paraquat 5 mM 48 hrs, 4-day adult  (1008) Paraquat 10 mM 48 hrs, 4-day adult  (1949) Rotenone 2 μg 12 hrs, larvae L3  (2207) Rotenone 8 μg 12 hrs, larvae L3  (2235) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (791) cold shock, 4-day adult  (834) heat shock, 4-day adult  (1172) Cadmium 50 mM 6 hrs, larvae L3  (1591) Cadmium 50 mM 12 hrs, larvae L3  (890) Cadmium 50 mM 48 hrs, 4-day adult  (998) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (424) Copper 15 mM 48 hrs, 4-day adult    60 Zinc 5 mM 12 hrs, larvae L3  (501) Zinc 4.5 mM 48 hrs, 4-day adult  (436) Ethanol 2.5% 3 hrs, larvae L3  (342) Ethanol 5% 3 hrs, larvae L3  (1480) Ethanol 10% 3 hrs, larvae L3  (1639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1576) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (310) Caffeine 25 mg/ml 48 hrs, 4-day adult  (644) Paraquat 5 mM 48 hrs, 4-day adult  (1008) Paraquat 10 mM 48 hrs, 4-day adult  (1949) Rotenone 2 μg 12 hrs, larvae L3  (2207) Rotenone 8 μg 12 hrs, larvae L3  (2235) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    791 cold shock, 4-day adult    834 heat shock, 4-day adult    1172 Cadmium 50 mM 6 hrs, larvae L3    1591 Cadmium 50 mM 12 hrs, larvae L3    890 Cadmium 50 mM 48 hrs, 4-day adult    998 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    424 Copper 15 mM 48 hrs, 4-day adult    60 Zinc 5 mM 12 hrs, larvae L3    501 Zinc 4.5 mM 48 hrs, 4-day adult    436 Ethanol 2.5% 3 hrs, larvae L3    342 Ethanol 5% 3 hrs, larvae L3    1480 Ethanol 10% 3 hrs, larvae L3    1639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1576 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    310 Caffeine 25 mg/ml 48 hrs, 4-day adult    644 Paraquat 5 mM 48 hrs, 4-day adult    1008 Paraquat 10 mM 48 hrs, 4-day adult    1949 Rotenone 2 μg 12 hrs, larvae L3    2207 Rotenone 8 μg 12 hrs, larvae L3    2235 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_16 mE1_20_mRNA_expression_cluster_16
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010357 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18211-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 βTryGD17765 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of βTry Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of βTry Class Mutagen Stocks Known lesion βTryGD17765 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes βTryKK113248 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6060 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 (FlyBase Curators et al., 2004-) non-traceable author statement (Magoulas, 1992, Ross et al., 2003, Swiss-Prot Project Members, 1996.10.1)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 (FlyBase Curators et al., 2004-) non-traceable author statement (Ross et al., 2003, Swiss-Prot Project Members, 1996.10.1)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Magoulas, 1992, Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions βTry allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0010357
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (2) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10793 Drosophila yakuba Dyak\GE12353
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v102898 P{KK113248}VIE-260B v50091 w1118; P{GD17765}v50091
Genomic Clones ( 1 )
	BACR29G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP01708 RE37763 RE40325
Other clones	DPiM_RE37763 FI16137 MIP25961 yak-ad_alphaTry
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05182 GH06507 LP06382
Other clones	Dmel_dig_007974_0724_0409 Dmel_dig_008491_0700_0578 EC25916 EC39613 IP04104 IP04204 IP14853 IP14953
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010357 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47901
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: βTry CG18211 (Bayraktaroglu, 2000.4.12)
Additional comments
Other Comments
	A clustered gene family (αTry, βTry, γTry and δTry) encoding trypsin-like enzymes has been cloned. (Davis et al., 1985) One of a cluster of trypsin-encoding genes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080165 RefSeq (Proteins) • NP_524904 DDBJ / EMBL / GenBank • AAA17451 AAA28980 AAF58658 AAV36962 BT016077 M96372 U04853 Entrez Gene - A searchable database of RefSeq genes. • 47901 UniProtKB/Swiss-Prot • P35004
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1 (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Peptidase S1, trypsin family, active site (IPR018114) Trypsin-like cysteine/serine peptidase domain (IPR009003) MEROPS - An information resource for peptidases and the proteins that inhibit them • S01.112
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0010357 DRSC - Results from RNAi screens. • FBgn0010357 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010357 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18211-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010357 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47901 modMine - Data generated by the modENCODE project. • FBgn0010357
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	beta (Wang et al., 1999) betaTry (Chakrabarti et al., 2012) CG18211 (Carrera et al., 2008, Keleman et al., 2009.8.5) DmBetaTry (Hickey, 1994.1.5) SP119 (Ross et al., 2003) Try (Magoulas, 1992) β (Davis et al., 1985) βTry (Kwon et al., 2008, Carrera et al., 2008)
Name Synonym	betaTrypsin (Harbison et al., 2005) βTrypsin
Secondary FlyBase IDs
	FBgn0033622
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 7 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 )
Recent research papers ( 1 )
	Chakrabarti et al., 2012, Cell Host Microbe 12(1): 60--70 Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. [FBrf0218984] Show all research papers ...