FB2025_02 , released April 17, 2025
Gene: Dmel\γTry
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General Information
Symbol
Dmel\γTry
Species
D. melanogaster
Name
γTrypsin
Annotation Symbol
CG30028
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010359
Gene Model Status
Current
Stock Availability
1 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
47F4-47F4
Sequence location
Recombination map
2-64
RefSeq locus
NT_033778 REGION:11349061..11349870
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables serine-type endopeptidase activity
inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114
(InterPro Project Members, 2004-)
inferred from sequence model
(Cao and Jiang, 2018)
inferred from biological aspect of ancestor with PANTHER:PTN001208729
(GO Reference Genome Project, 2011-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114
(InterPro Project Members, 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase S1 family. (C0HKA3)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
S1A SERINE PROTEASES - TRYPSIN-LIKE -
Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Try: Trypsin
Structural gene for enzyme trypsin.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\γTry for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry C0HKA3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Apparent introns not annotated: probable artifacts due to repetitive sequence.

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
γTry-RA
FBtr0088159
NM_165823
810
253
Additional Transcript Data and Comments
Reported size (kB)

0.5 (unknown)

(Davis et al., 1985)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
γTry-PA
FBpp0087255
25.7
253
8.26
C0HKA2
NP_725034
AAM68730
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\γTry using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval digestive system | restricted

Comment: expressed in the gut

(Davis et al., 1985)
adult stage
(Davis et al., 1985)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
second instar larval stage
(Lipinszki et al., 2013)
third instar larval stage
(Lipinszki et al., 2013)
Additional Descriptive Data

Transcripts increase sharply in the second instar larval stage, peak in 72-84 hr L2/L3 and then decline slowly in third instar larvae. Very low levels are seen in embryos, pupae and adults. The probe does not distinguish between the distribution of γTry, δTry, and CG30031 transcripts, all of which encode identical polypeptides.

(Lipinszki et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\γTry in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of γTry
Transgenic constructs containing regulatory region of γTry
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6060
(Ryder, 2004.4.26)
Inferred from location ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (94)
Hsap\PRSS1
6 of 14
Yes
No
Hsap\PRSS3
6 of 14
Yes
No
Hsap\PRSS2
5 of 14
No
No
Hsap\KLK3
4 of 14
No
No
Hsap\KLK11
4 of 14
No
No
Hsap\KLK14
4 of 14
No
No
Hsap\KLK15
4 of 14
No
No
Hsap\PRSS3P2
4 of 14
No
No
Hsap\KLK1
3 of 14
No
No
Hsap\KLK2
3 of 14
No
No
Hsap\KLK4
3 of 14
No
No
Hsap\KLK5
3 of 14
No
No
Hsap\KLK6
3 of 14
No
No
Hsap\KLK8
3 of 14
No
No
Hsap\KLK9
3 of 14
No
No
Hsap\KLK10
3 of 14
No
No
Hsap\KLK12
3 of 14
No
No
Hsap\KLK13
3 of 14
No
No
Hsap\PRSS38
3 of 14
No
Yes
Hsap\AZU1
2 of 14
No
Yes
Hsap\CFD
2 of 14
No
Yes
Hsap\ELANE
2 of 14
No
Yes
Hsap\KLK7
2 of 14
No
No
Hsap\PRSS8
2 of 14
No
No
1  
Hsap\PRSS22
2 of 14
No
No
Hsap\PRSS27
2 of 14
No
No
Hsap\PRSS29P
2 of 14
No
Yes
Hsap\PRSS33
2 of 14
No
No
Hsap\PRSS36
2 of 14
No
No
Hsap\PRSS45P
2 of 14
No
Yes
Hsap\PRSS53
2 of 14
No
No
Hsap\PRSS57
2 of 14
No
Yes
Hsap\PRTN3
2 of 14
No
Yes
Hsap\TMPRSS2
2 of 14
No
No
Hsap\TMPRSS3
2 of 14
No
No
Hsap\TMPRSS5
2 of 14
No
No
Hsap\TPSAB1
2 of 14
No
No
Hsap\TPSG1
2 of 14
No
No
Hsap\ACR
1 of 14
No
No
Hsap\C1S
1 of 14
No
No
1  
Hsap\CELA1
1 of 14
No
No
Hsap\CELA2A
1 of 14
No
No
Hsap\CELA2B
1 of 14
No
No
Hsap\CELA3A
1 of 14
No
No
Hsap\CELA3B
1 of 14
No
No
Hsap\CFI
1 of 14
No
Yes
Hsap\CORIN
1 of 14
No
No
Hsap\CTRB1
1 of 14
No
No
Hsap\CTRB2
1 of 14
No
No
Hsap\CTRC
1 of 14
No
No
Hsap\CTRL
1 of 14
No
No
Hsap\F2
1 of 14
No
No
Hsap\F7
1 of 14
No
No
Hsap\F9
1 of 14
No
No
1  
Hsap\F10
1 of 14
No
No
1  
Hsap\F11
1 of 14
No
No
1  
Hsap\F12
1 of 14
No
No
Hsap\GZMA
1 of 14
No
No
Hsap\GZMH
1 of 14
No
No
1  
Hsap\GZMK
1 of 14
No
No
Hsap\GZMM
1 of 14
No
Yes
Hsap\HABP2
1 of 14
No
No
Hsap\HPN
1 of 14
No
No
1  
Hsap\KLKB1
1 of 14
No
No
Hsap\LPA
1 of 14
No
No
Hsap\MASP1
1 of 14
No
No
1  
Hsap\OVCH1
1 of 14
No
No
Hsap\OVCH2
1 of 14
No
No
Hsap\PLAT
1 of 14
No
No
1  
Hsap\PLAU
1 of 14
No
No
1  
Hsap\PLG
1 of 14
No
No
1  
Hsap\PROC
1 of 14
No
No
1  
Hsap\PRSS12
1 of 14
No
No
Hsap\PRSS21
1 of 14
No
No
Hsap\PRSS41
1 of 14
No
No
Hsap\PRSS42P
1 of 14
No
No
Hsap\PRSS48
1 of 14
No
No
Hsap\PRSS55
1 of 14
No
No
Hsap\PRSS56
1 of 14
No
No
Hsap\PRSS58
1 of 14
No
Yes
Hsap\ST14
1 of 14
No
No
1  
Hsap\TMPRSS4
1 of 14
No
No
Hsap\TMPRSS6
1 of 14
No
No
Hsap\TMPRSS7
1 of 14
No
No
Hsap\TMPRSS9
1 of 14
No
No
Hsap\TMPRSS11A
1 of 14
No
No
Hsap\TMPRSS11B
1 of 14
No
No
Hsap\TMPRSS11D
1 of 14
No
No
Hsap\TMPRSS11E
1 of 14
No
No
Hsap\TMPRSS11F
1 of 14
No
No
Hsap\TMPRSS12
1 of 14
No
No
Hsap\TMPRSS13
1 of 14
No
No
Hsap\TMPRSS15
1 of 14
No
No
Hsap\TPSD1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (105)
Rnor\LOC286960
7 of 14
Yes
No
Rnor\LOC312273
7 of 14
Yes
No
Rnor\LOC683849
7 of 14
Yes
No
Rnor\Prss1
7 of 14
Yes
No
Rnor\Prss2
7 of 14
Yes
No
Rnor\Prss3b
7 of 14
Yes
No
Rnor\Prss3
7 of 14
Yes
No
Rnor\Try5
7 of 14
Yes
No
Rnor\Try10
7 of 14
Yes
No
Rnor\Klk14
6 of 14
No
Yes
Rnor\Klk11
5 of 14
No
Yes
Rnor\Klk15
5 of 14
No
Yes
Rnor\Klk1c3
4 of 14
No
Yes
Rnor\Klk8
4 of 14
No
Yes
Rnor\Klk9
4 of 14
No
Yes
Rnor\Klk10
4 of 14
No
Yes
Rnor\Klk13
4 of 14
No
Yes
Rnor\Klk1b3
3 of 14
No
Yes
Rnor\Klk1c6
3 of 14
No
Yes
Rnor\Klk1c8
3 of 14
No
Yes
Rnor\Klk1c9
3 of 14
No
Yes
Rnor\Klk1c12
3 of 14
No
Yes
Rnor\Klk1
3 of 14
No
No
Rnor\Klk4
3 of 14
No
No
Rnor\Klk6
3 of 14
No
Yes
Rnor\Klk12
3 of 14
No
Yes
Rnor\Prss29
3 of 14
No
Yes
Rnor\Prss34
3 of 14
No
Yes
Rnor\Tmprss11c
3 of 14
No
Yes
Rnor\Cela3b
2 of 14
No
No
Rnor\Cfd
2 of 14
No
No
Rnor\Ctrb1
2 of 14
No
No
Rnor\Ctrl
2 of 14
No
No
Rnor\Elane
2 of 14
No
Yes
Rnor\Gzma
2 of 14
No
Yes
Rnor\Hpn
2 of 14
No
No
Rnor\Klk1c2
2 of 14
No
No
Rnor\Klk5
2 of 14
No
Yes
Rnor\LOC685321
2 of 14
No
Yes
Rnor\Prss8
2 of 14
No
No
Rnor\Prss21
2 of 14
No
No
Rnor\Prss22
2 of 14
No
No
Rnor\Prss27
2 of 14
No
No
Rnor\Prss32
2 of 14
No
No
Rnor\Prss36
2 of 14
No
No
Rnor\Prss38
2 of 14
No
Yes
Rnor\Prss42
2 of 14
No
No
Rnor\Prss48
2 of 14
No
No
Rnor\Prss53
2 of 14
No
No
Rnor\Prtn3
2 of 14
No
Yes
Rnor\Tmprss2
2 of 14
No
No
Rnor\Tmprss3
2 of 14
No
No
Rnor\Tmprss5
2 of 14
No
No
Rnor\Tmprss11a
2 of 14
No
Yes
Rnor\Tmprss11e
2 of 14
No
Yes
Rnor\Tmprss11g
2 of 14
No
No
Rnor\Tpsab1
2 of 14
No
No
Rnor\Tpsb2
2 of 14
No
No
Rnor\Tpsg1
2 of 14
No
No
Rnor\Cela1
1 of 14
No
No
Rnor\Cela2a
1 of 14
No
No
Rnor\Cma1
1 of 14
No
Yes
Rnor\Ctrc
1 of 14
No
No
Rnor\F11
1 of 14
No
No
Rnor\Gzmbl1
1 of 14
No
No
Rnor\Gzmbl3
1 of 14
No
No
Rnor\Gzmb
1 of 14
No
No
Rnor\Gzmc
1 of 14
No
No
Rnor\Gzmf
1 of 14
No
No
Rnor\Gzmm
1 of 14
No
Yes
Rnor\Gzmn
1 of 14
No
No
Rnor\Klkb1
1 of 14
No
No
Rnor\LOC683422
1 of 14
No
No
Rnor\LOC691670
1 of 14
No
No
Rnor\LOC102554637
1 of 14
No
Yes
Rnor\Mcpt1l3
1 of 14
No
No
Rnor\Mcpt1l4
1 of 14
No
No
Rnor\Mcpt1
1 of 14
No
No
Rnor\Mcpt2
1 of 14
No
No
Rnor\Mcpt4
1 of 14
No
No
Rnor\Mcpt8l2
1 of 14
No
No
Rnor\Mcpt8
1 of 14
No
No
Rnor\Mcpt10
1 of 14
No
No
Rnor\Ovch2
1 of 14
No
No
Rnor\Plg
1 of 14
No
No
Rnor\Prss30
1 of 14
No
No
Rnor\Prss33
1 of 14
No
No
Rnor\Prss40
1 of 14
No
Yes
Rnor\Prss41
1 of 14
No
No
Rnor\Prss44
1 of 14
No
No
Rnor\Prss47
1 of 14
No
No
Rnor\Prss55
1 of 14
No
No
Rnor\Prss56
1 of 14
No
No
Rnor\Prss57
1 of 14
No
No
Rnor\RGD1559662
1 of 14
No
Yes
Rnor\St14
1 of 14
No
No
Rnor\Tmprss4
1 of 14
No
No
Rnor\Tmprss6
1 of 14
No
No
Rnor\Tmprss7
1 of 14
No
No
Rnor\Tmprss9
1 of 14
No
No
Rnor\Tmprss11b
1 of 14
No
No
Rnor\Tmprss11d
1 of 14
No
No
Rnor\Tmprss11f
1 of 14
No
No
Rnor\Tmprss13
1 of 14
No
No
Rnor\Tryx5
1 of 14
No
No
Mus musculus (laboratory mouse) (96)
Mmus\1810009J06Rik
5 of 14
Yes
No
Mmus\2210010C04Rik
5 of 14
Yes
No
Mmus\Gm2663
5 of 14
Yes
No
Mmus\Gm5771
5 of 14
Yes
No
Mmus\Gm10334
5 of 14
Yes
No
Mmus\Klk14
5 of 14
Yes
Yes
Mmus\Prss1
5 of 14
Yes
No
Mmus\Prss2
5 of 14
Yes
No
Mmus\Prss3
5 of 14
Yes
No
Mmus\Try4
5 of 14
Yes
No
Mmus\Try5
5 of 14
Yes
No
Mmus\Try10
5 of 14
Yes
No
Mmus\Klk4
4 of 14
No
No
Mmus\Klk9
4 of 14
No
Yes
Mmus\Klk11
4 of 14
No
No
Mmus\Klk12
4 of 14
No
No
Mmus\Klk15
4 of 14
No
Yes
Mmus\Egfbp2
3 of 14
No
Yes
Mmus\Klk1b1
3 of 14
No
No
Mmus\Klk1b3
3 of 14
No
No
Mmus\Klk1b4
3 of 14
No
No
Mmus\Klk1b5
3 of 14
No
No
Mmus\Klk1b8
3 of 14
No
No
Mmus\Klk1b9
3 of 14
No
No
Mmus\Klk1b11
3 of 14
No
No
Mmus\Klk1b21
3 of 14
No
No
Mmus\Klk1b22
3 of 14
No
No
Mmus\Klk1b24
3 of 14
No
No
Mmus\Klk1b26
3 of 14
No
No
Mmus\Klk1
3 of 14
No
No
Mmus\Klk5
3 of 14
No
No
Mmus\Klk6
3 of 14
No
No
Mmus\Klk7
3 of 14
No
No
Mmus\Klk8
3 of 14
No
No
Mmus\Klk10
3 of 14
No
No
Mmus\Klk13
3 of 14
No
No
Mmus\Prss28
3 of 14
No
Yes
Mmus\Prss29
3 of 14
No
Yes
Mmus\Prss34
3 of 14
No
Yes
Mmus\Cfd
2 of 14
No
Yes
Mmus\Klk1b27
2 of 14
No
No
Mmus\Prss36
2 of 14
No
No
Mmus\Prss38
2 of 14
No
Yes
Mmus\Prss52
2 of 14
No
Yes
Mmus\Prss53
2 of 14
No
No
Mmus\Prtn3
2 of 14
No
Yes
Mmus\St14
2 of 14
No
No
Mmus\Tmprss7
2 of 14
No
No
Mmus\Cela2a
1 of 14
No
No
Mmus\Cela3a
1 of 14
No
No
Mmus\Cela3b
1 of 14
No
No
Mmus\Ctrb1
1 of 14
No
No
Mmus\Ctrc
1 of 14
No
No
Mmus\Ctrl
1 of 14
No
No
Mmus\Elane
1 of 14
No
No
Mmus\F11
1 of 14
No
No
Mmus\Gm5409
1 of 14
No
Yes
Mmus\Gzma
1 of 14
No
No
Mmus\Gzmm
1 of 14
No
Yes
Mmus\Hpn
1 of 14
No
No
Mmus\Klk1b16
1 of 14
No
No
Mmus\Klkb1
1 of 14
No
No
Mmus\Ovch2
1 of 14
No
No
Mmus\Proc
1 of 14
No
No
Mmus\Prss8
1 of 14
No
No
Mmus\Prss21
1 of 14
No
No
Mmus\Prss22
1 of 14
No
No
Mmus\Prss30
1 of 14
No
No
Mmus\Prss32
1 of 14
No
No
Mmus\Prss39
1 of 14
No
Yes
Mmus\Prss41
1 of 14
No
No
Mmus\Prss42
1 of 14
No
No
Mmus\Prss44
1 of 14
No
No
Mmus\Prss45
1 of 14
No
No
Mmus\Prss47
1 of 14
No
No
Mmus\Prss48
1 of 14
No
No
Mmus\Prss55
1 of 14
No
No
Mmus\Prss56
1 of 14
No
No
Mmus\Prss57
1 of 14
No
No
Mmus\Prss59
1 of 14
No
No
Mmus\Tmprss2
1 of 14
No
No
Mmus\Tmprss3
1 of 14
No
No
Mmus\Tmprss4
1 of 14
No
No
Mmus\Tmprss5
1 of 14
No
No
Mmus\Tmprss6
1 of 14
No
No
Mmus\Tmprss9
1 of 14
No
No
Mmus\Tmprss11b
1 of 14
No
No
Mmus\Tmprss11c
1 of 14
No
No
Mmus\Tmprss11d
1 of 14
No
No
Mmus\Tmprss11e
1 of 14
No
No
Mmus\Tmprss11f
1 of 14
No
No
Mmus\Tmprss11g
1 of 14
No
No
Mmus\Tmprss13
1 of 14
No
No
Mmus\Tpsab1
1 of 14
No
No
Mmus\Tpsb2
1 of 14
No
No
Mmus\Tpsg1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (64)
Xtro\akt1
4 of 13
Yes
No
Xtro\sdhaf4
4 of 13
Yes
No
Xtro\LOC101730988
2 of 13
No
No
Xtro\LOC101732176
2 of 13
No
No
Xtro\prss2
2 of 13
No
No
Xtro\tmprss2.12
2 of 13
No
No
Xtro\cela1.1
1 of 13
No
No
Xtro\cela1.2
1 of 13
No
No
Xtro\cela1.4
1 of 13
No
No
Xtro\cfd
1 of 13
No
No
Xtro\corin
1 of 13
No
No
Xtro\f2
1 of 13
No
No
Xtro\f7
1 of 13
No
No
Xtro\f12
1 of 13
No
No
Xtro\gzma
1 of 13
No
No
Xtro\hgfac
1 of 13
No
No
Xtro\hoxc4
1 of 13
No
No
Xtro\klk15
1 of 13
No
Yes
Xtro\klkb1
1 of 13
No
No
Xtro\krt8.1
1 of 13
No
Yes
Xtro\LOC496623
1 of 13
No
No
Xtro\LOC496633
1 of 13
No
Yes
Xtro\LOC548809
1 of 13
No
No
Xtro\LOC100485189
1 of 13
No
No
Xtro\LOC100490788
1 of 13
No
Yes
Xtro\LOC100491119
1 of 13
No
No
Xtro\LOC100495541
1 of 13
No
No
Xtro\LOC100497505
1 of 13
No
No
Xtro\LOC100498083
1 of 13
No
No
Xtro\LOC100498532
1 of 13
No
No
Xtro\LOC101730792
1 of 13
No
Yes
Xtro\LOC101730924
1 of 13
No
No
Xtro\LOC101733280
1 of 13
No
No
Xtro\LOC101734670
1 of 13
No
No
Xtro\LOC105945797
1 of 13
No
Yes
Xtro\LOC108647852
1 of 13
No
No
Xtro\LOC108648818
1 of 13
No
No
Xtro\LOC116407662
1 of 13
No
No
Xtro\LOC116411715
1 of 13
No
No
Xtro\LOC116412104
1 of 13
No
No
Xtro\mettl7a.2
1 of 13
No
No
Xtro\pafah1b3
1 of 13
No
No
Xtro\proc.2
1 of 13
No
No
Xtro\prss1.2
1 of 13
No
No
Xtro\prss1
1 of 13
No
No
Xtro\prss3
1 of 13
No
Yes
Xtro\prss8
1 of 13
No
No
Xtro\prss12
1 of 13
No
No
Xtro\prss27
1 of 13
No
No
Xtro\prss29
1 of 13
No
No
Xtro\prss56
1 of 13
No
No
Xtro\prtn3
1 of 13
No
No
Xtro\tmprss2.1
1 of 13
No
No
Xtro\tmprss2.6
1 of 13
No
Yes
Xtro\tmprss3
1 of 13
No
No
Xtro\tmprss6
1 of 13
No
No
Xtro\tmprss13
1 of 13
No
No
Xtro\tmprss15
1 of 13
No
No
Xtro\tpsg1
1 of 13
No
No
Xtro\try10
1 of 13
No
Yes
Xtro\XB5723326
1 of 13
No
No
Xtro\XB5758585
1 of 13
No
Yes
Xtro\XB5892359
1 of 13
No
No
Xtro\zfand4
1 of 13
No
Yes
Danio rerio (Zebrafish) (64)
Drer\prss1
6 of 14
Yes
No
Drer\zgc:92590
6 of 14
Yes
No
Drer\prss59.1
4 of 14
No
No
Drer\prss59.2
4 of 14
No
No
Drer\si:dkey-33m11.7
4 of 14
No
Yes
Drer\zgc:171509
4 of 14
No
No
Drer\LOC560023
3 of 14
No
No
Drer\LOC103908930
3 of 14
No
No
Drer\si:dkey-33m11.8
3 of 14
No
No
Drer\zmp:0000001088
3 of 14
No
No
Drer\tmprss2
2 of 14
No
No
Drer\cela1.1
1 of 14
No
No
Drer\cfd
1 of 14
No
No
Drer\ctrb.1
1 of 14
No
No
Drer\ctrb.3
1 of 14
No
No
Drer\ctrl
1 of 14
No
No
Drer\ela2
1 of 14
No
No
Drer\ela2l
1 of 14
No
No
Drer\ela3l
1 of 14
No
No
Drer\f7
1 of 14
No
No
Drer\f7l
1 of 14
No
No
Drer\gzm3.2
1 of 14
No
No
Drer\gzm3.4
1 of 14
No
No
Drer\gzma
1 of 14
No
No
Drer\hpn
1 of 14
No
No
Drer\LOC558805
1 of 14
No
No
Drer\LOC562139
1 of 14
No
No
Drer\LOC100331291
1 of 14
No
No
Drer\ovch1
1 of 14
No
No
Drer\plaua
1 of 14
No
No
Drer\plg
1 of 14
No
No
Drer\prss60.1
1 of 14
No
No
Drer\prss60.2
1 of 14
No
No
Drer\si:ch73-127m5.1
1 of 14
No
No
Drer\si:ch73-182e20.4
1 of 14
No
No
Drer\si:dkey-21e2.3
1 of 14
No
No
Drer\si:dkey-21e2.10
1 of 14
No
No
Drer\si:dkey-21e2.11
1 of 14
No
No
Drer\si:dkey-21e2.12
1 of 14
No
No
Drer\si:dkey-21e2.14
1 of 14
No
No
Drer\si:dkey-32n7.7
1 of 14
No
No
Drer\si:dkey-78l4.13
1 of 14
No
No
Drer\si:dkeyp-93a5.2
1 of 14
No
No
Drer\si:dkeyp-93a5.3
1 of 14
No
No
Drer\st14a
1 of 14
No
No
Drer\st14b
1 of 14
No
No
Drer\tmprss3a
1 of 14
No
No
Drer\tmprss3b
1 of 14
No
No
Drer\tmprss4a
1 of 14
No
No
Drer\tmprss4b
1 of 14
No
No
Drer\tmprss5
1 of 14
No
No
Drer\tmprss9
1 of 14
No
No
Drer\tmprss12
1 of 14
No
No
Drer\tmprss13a
1 of 14
No
No
Drer\tmprss15
1 of 14
No
No
Drer\zgc:100868
1 of 14
No
No
Drer\zgc:112038
1 of 14
No
No
Drer\zgc:112285
1 of 14
No
No
Drer\zgc:123217
1 of 14
No
No
Drer\zgc:123295
1 of 14
No
No
Drer\zgc:153968
1 of 14
No
No
Drer\zgc:165423
1 of 14
No
No
Drer\zgc:171592
1 of 14
No
No
Drer\zmp:0000001114
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\try-1
2 of 14
Yes
No
Cele\try-10
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (179)
Agam\AgaP_AGAP011477
7 of 12
Yes
Yes
Agam\AgaP_AGAP008861
5 of 12
No
No
Agam\AgaP_AGAP009966
5 of 12
No
No
Agam\TRY1_ANOGA
5 of 12
No
No
Agam\TRY3_ANOGA
5 of 12
No
No
Agam\TRY5_ANOGA
5 of 12
No
No
Agam\TRY6_ANOGA
5 of 12
No
No
Agam\TRY7_ANOGA
5 of 12
No
No
Agam\AgaP_AGAP001241
4 of 12
No
No
Agam\AgaP_AGAP001245
4 of 12
No
No
Agam\AgaP_AGAP001246
4 of 12
No
No
Agam\AgaP_AGAP001247
4 of 12
No
No
Agam\AgaP_AGAP001248
4 of 12
No
No
Agam\AgaP_AGAP001249
4 of 12
No
No
Agam\AgaP_AGAP001250
4 of 12
No
No
Agam\AgaP_AGAP001252
4 of 12
No
No
Agam\AgaP_AGAP004770
4 of 12
No
No
Agam\AgaP_AGAP006869
4 of 12
No
No
Agam\AgaP_AGAP011590
4 of 12
No
Yes
Agam\TRY2_ANOGA
4 of 12
No
No
Agam\TRY4_ANOGA
4 of 12
No
No
Agam\AgaP_AGAP001251
3 of 12
No
No
Agam\AgaP_AGAP003807
3 of 12
No
No
Agam\AgaP_AGAP003971
3 of 12
No
Yes
Agam\AgaP_AGAP004900
3 of 12
No
No
Agam\AgaP_AGAP005065
3 of 12
No
No
Agam\AgaP_AGAP005194
3 of 12
No
No
Agam\AgaP_AGAP005195
3 of 12
No
Yes
Agam\AgaP_AGAP005196
3 of 12
No
No
Agam\AgaP_AGAP006539
3 of 12
No
No
Agam\AgaP_AGAP006707
3 of 12
No
No
Agam\AgaP_AGAP007141
3 of 12
No
No
Agam\AgaP_AGAP007142
3 of 12
No
No
Agam\AgaP_AGAP010243
3 of 12
No
Yes
Agam\AgaP_AGAP010619
3 of 12
No
No
Agam\AgaP_AGAP011918
3 of 12
No
Yes
Agam\AgaP_AGAP011919
3 of 12
No
No
Agam\AgaP_AGAP012842
3 of 12
No
No
Agam\CTR1_ANOGA
3 of 12
No
No
Agam\SP24D_ANOGA
3 of 12
No
No
Agam\AgaP_AGAP001198
2 of 12
No
No
Agam\AgaP_AGAP001244
2 of 12
No
No
Agam\AgaP_AGAP002432
2 of 12
No
No
Agam\AgaP_AGAP004566
2 of 12
No
No
Agam\AgaP_AGAP004567
2 of 12
No
No
Agam\AgaP_AGAP004568
2 of 12
No
No
Agam\AgaP_AGAP005310
2 of 12
No
No
Agam\AgaP_AGAP005663
2 of 12
No
No
Agam\AgaP_AGAP005664
2 of 12
No
No
Agam\AgaP_AGAP005665
2 of 12
No
No
Agam\AgaP_AGAP005669
2 of 12
No
No
Agam\AgaP_AGAP005670
2 of 12
No
No
Agam\AgaP_AGAP005671
2 of 12
No
No
Agam\AgaP_AGAP005687
2 of 12
No
No
Agam\AgaP_AGAP005688
2 of 12
No
No
Agam\AgaP_AGAP005689
2 of 12
No
No
Agam\AgaP_AGAP005690
2 of 12
No
No
Agam\AgaP_AGAP005691
2 of 12
No
No
Agam\AgaP_AGAP005791
2 of 12
No
Yes
Agam\AgaP_AGAP005792
2 of 12
No
Yes
Agam\AgaP_AGAP006087
2 of 12
No
No
Agam\AgaP_AGAP006385
2 of 12
No
No
Agam\AgaP_AGAP006485
2 of 12
No
Yes
Agam\AgaP_AGAP006486
2 of 12
No
Yes
Agam\AgaP_AGAP006487
2 of 12
No
Yes
Agam\AgaP_AGAP006674
2 of 12
No
No
Agam\AgaP_AGAP006710
2 of 12
No
No
Agam\AgaP_AGAP007262
2 of 12
No
No
Agam\AgaP_AGAP008276
2 of 12
No
Yes
Agam\AgaP_AGAP008649
2 of 12
No
No
Agam\AgaP_AGAP010240
2 of 12
No
No
Agam\AgaP_AGAP010798
2 of 12
No
No
Agam\AgaP_AGAP011917
2 of 12
No
No
Agam\AgaP_AGAP011920
2 of 12
No
No
Agam\AgaP_AGAP012473
2 of 12
No
No
Agam\AgaP_AGAP012491
2 of 12
No
No
Agam\AgaP_AGAP012566
2 of 12
No
No
Agam\AgaP_AGAP012778
2 of 12
No
Yes
Agam\CTR2_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP001190
1 of 12
No
No
Agam\AgaP_AGAP001199
1 of 12
No
No
Agam\AgaP_AGAP001365
1 of 12
No
No
Agam\AgaP_AGAP001395
1 of 12
No
No
Agam\AgaP_AGAP001924
1 of 12
No
No
Agam\AgaP_AGAP001964
1 of 12
No
No
Agam\AgaP_AGAP002543
1 of 12
No
No
Agam\AgaP_AGAP003248
1 of 12
No
No
Agam\AgaP_AGAP003686
1 of 12
No
No
Agam\AgaP_AGAP004149
1 of 12
No
No
Agam\AgaP_AGAP004552
1 of 12
No
No
Agam\AgaP_AGAP004569
1 of 12
No
No
Agam\AgaP_AGAP004570
1 of 12
No
No
Agam\AgaP_AGAP004571
1 of 12
No
No
Agam\AgaP_AGAP004741
1 of 12
No
No
Agam\AgaP_AGAP004858
1 of 12
No
No
Agam\AgaP_AGAP005642
1 of 12
No
No
Agam\AgaP_AGAP005686
1 of 12
No
No
Agam\AgaP_AGAP005702
1 of 12
No
No
Agam\AgaP_AGAP005703
1 of 12
No
No
Agam\AgaP_AGAP005704
1 of 12
No
No
Agam\AgaP_AGAP005705
1 of 12
No
No
Agam\AgaP_AGAP005706
1 of 12
No
No
Agam\AgaP_AGAP005708
1 of 12
No
No
Agam\AgaP_AGAP005790
1 of 12
No
Yes
Agam\AgaP_AGAP006120
1 of 12
No
No
Agam\AgaP_AGAP006672
1 of 12
No
No
Agam\AgaP_AGAP006673
1 of 12
No
No
Agam\AgaP_AGAP006675
1 of 12
No
No
Agam\AgaP_AGAP006676
1 of 12
No
No
Agam\AgaP_AGAP006677
1 of 12
No
No
Agam\AgaP_AGAP007251
1 of 12
No
No
Agam\AgaP_AGAP007252
1 of 12
No
No
Agam\AgaP_AGAP007280
1 of 12
No
No
Agam\AgaP_AGAP008277
1 of 12
No
No
Agam\AgaP_AGAP008994
1 of 12
No
No
Agam\AgaP_AGAP008996
1 of 12
No
No
Agam\AgaP_AGAP008997
1 of 12
No
No
Agam\AgaP_AGAP009000
1 of 12
No
No
Agam\AgaP_AGAP009121
1 of 12
No
No
Agam\AgaP_AGAP009122
1 of 12
No
No
Agam\AgaP_AGAP009211
1 of 12
No
No
Agam\AgaP_AGAP009220
1 of 12
No
No
Agam\AgaP_AGAP009249
1 of 12
No
No
Agam\AgaP_AGAP009273
1 of 12
No
No
Agam\AgaP_AGAP009828
1 of 12
No
No
Agam\AgaP_AGAP009849
1 of 12
No
No
Agam\AgaP_AGAP010015
1 of 12
No
No
Agam\AgaP_AGAP010614
1 of 12
No
No
Agam\AgaP_AGAP010615
1 of 12
No
No
Agam\AgaP_AGAP010617
1 of 12
No
No
Agam\AgaP_AGAP010618
1 of 12
No
No
Agam\AgaP_AGAP010620
1 of 12
No
No
Agam\AgaP_AGAP010659
1 of 12
No
No
Agam\AgaP_AGAP010661
1 of 12
No
No
Agam\AgaP_AGAP010663
1 of 12
No
No
Agam\AgaP_AGAP010692
1 of 12
No
No
Agam\AgaP_AGAP011325
1 of 12
No
No
Agam\AgaP_AGAP011908
1 of 12
No
No
Agam\AgaP_AGAP011910
1 of 12
No
No
Agam\AgaP_AGAP011912
1 of 12
No
No
Agam\AgaP_AGAP012328
1 of 12
No
No
Agam\AgaP_AGAP012470
1 of 12
No
No
Agam\AgaP_AGAP012472
1 of 12
No
Yes
Agam\AgaP_AGAP012492
1 of 12
No
No
Agam\AgaP_AGAP012670
1 of 12
No
No
Agam\AgaP_AGAP012671
1 of 12
No
No
Agam\AgaP_AGAP012692
1 of 12
No
No
Agam\AgaP_AGAP013089
1 of 12
No
No
Agam\AgaP_AGAP013164
1 of 12
No
No
Agam\AgaP_AGAP013221
1 of 12
No
No
Agam\AgaP_AGAP013487
1 of 12
No
No
Agam\CLIPA4
1 of 12
No
No
Agam\CLIPA10
1 of 12
No
No
Agam\CLIPA19
1 of 12
No
No
Agam\CLIPB1
1 of 12
No
No
Agam\CLIPB2
1 of 12
No
No
Agam\CLIPB3
1 of 12
No
No
Agam\CLIPB4
1 of 12
No
No
Agam\CLIPB5
1 of 12
No
No
Agam\CLIPB6
1 of 12
No
No
Agam\CLIPB9
1 of 12
No
No
Agam\CLIPB10
1 of 12
No
No
Agam\CLIPB11
1 of 12
No
No
Agam\CLIPB13
1 of 12
No
No
Agam\CLIPB15
1 of 12
No
No
Agam\CLIPB17
1 of 12
No
No
Agam\CLIPB18
1 of 12
No
No
Agam\CLIPB19
1 of 12
No
No
Agam\CLIPC5
1 of 12
No
No
Agam\CLIPC6
1 of 12
No
No
Agam\CLIPC10
1 of 12
No
No
Agam\CLIPD1
1 of 12
No
No
Agam\CLIPD2
1 of 12
No
No
Agam\CLIPD3
1 of 12
No
No
Agam\CLIPD4
1 of 12
No
No
Agam\CLIPD6
1 of 12
No
No
Agam\CLIPD7
1 of 12
No
No
Agam\CLIPD8
1 of 12
No
No
Agam\SCRASP1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:γTry. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (202)
αTry
12 of 13
βTry
12 of 13
CG30025
12 of 13
εTry
11 of 13
Ser8
11 of 13
CG11192
10 of 13
ιTry
10 of 13
CG17239
9 of 13
CG17571
9 of 13
Ser12
9 of 13
λTry
8 of 13
θTry
8 of 13
CG7829
7 of 13
CG8299
7 of 13
CG31954
7 of 13
Try29F
7 of 13
ζTry
7 of 13
CG10405
6 of 13
CG17234
6 of 13
CG31681
6 of 13
CG32374
6 of 13
ηTry
6 of 13
Send1
6 of 13
CG9676
5 of 13
CG13430
5 of 13
CG33159
5 of 13
κTry
5 of 13
Ser6
5 of 13
CG1304
4 of 13
CG4653
4 of 13
CG14780
4 of 13
CG16749
4 of 13
CG16998
4 of 13
CG17242
4 of 13
CG30031
4 of 13
CG32269
4 of 13
CG32270
4 of 13
CG32271
4 of 13
CG32376
4 of 13
CG32523
4 of 13
CG32808
4 of 13
CG34458
4 of 13
δTry
4 of 13
sphe
4 of 13
CG3650
3 of 13
CG4053
3 of 13
CG5246
3 of 13
CG5255
3 of 13
CG6041
3 of 13
CG9897
3 of 13
CG10587
3 of 13
CG11037
3 of 13
CG12951
3 of 13
CG17475
3 of 13
CG17477
3 of 13
CG31265
3 of 13
CG31266
3 of 13
CG31267
3 of 13
CG31269
3 of 13
CG32277
3 of 13
CG32833
3 of 13
CG32834
3 of 13
CG33160
3 of 13
CG34129
3 of 13
Sems
3 of 13
Send2
3 of 13
CG3355
2 of 13
CG3795
2 of 13
CG3916
2 of 13
CG4271
2 of 13
CG7542
2 of 13
CG9672
2 of 13
CG9673
2 of 13
CG10469
2 of 13
CG10472
2 of 13
CG10477
2 of 13
CG10764
2 of 13
CG11911
2 of 13
CG12256
2 of 13
CG18636
2 of 13
CG30083
2 of 13
CG30087
2 of 13
CG30088
2 of 13
CG30098
2 of 13
CG30289
2 of 13
CG32755
2 of 13
CG33461
2 of 13
CG34130
2 of 13
CG34290
2 of 13
CG43335
2 of 13
CG43336
2 of 13
Erasp
2 of 13
Jon25Bii
2 of 13
Jon44E
2 of 13
Jon65Aiii
2 of 13
Jon65Aiv
2 of 13
Jon74E
2 of 13
Jon99Ciii
2 of 13
Jon99Fii
2 of 13
Jon99Fi
2 of 13
Phae1
2 of 13
Phae2
2 of 13
yip7
2 of 13
CG1299
1 of 13
CG1773
1 of 13
CG3088
1 of 13
CG3505
1 of 13
CG3700
1 of 13
CG4613
1 of 13
CG4815
1 of 13
CG4914
1 of 13
CG4927
1 of 13
CG4998
1 of 13
CG5909
1 of 13
CG6048
1 of 13
CG6462
1 of 13
CG6592
1 of 13
CG6865
1 of 13
CG7142
1 of 13
CG7432
1 of 13
CG8170
1 of 13
CG8172
1 of 13
CG8329
1 of 13
CG8870
1 of 13
CG8952
1 of 13
CG9294
1 of 13
CG9372
1 of 13
CG9733
1 of 13
CG9737
1 of 13
CG10041
1 of 13
CG10232
1 of 13
CG10663
1 of 13
CG11313
1 of 13
CG11529
1 of 13
CG11664
1 of 13
CG11836
1 of 13
CG11843
1 of 13
CG11912
1 of 13
CG13318
1 of 13
CG13744
1 of 13
CG14227
1 of 13
CG14642
1 of 13
CG15498
1 of 13
CG16710
1 of 13
CG17404
1 of 13
CG18179
1 of 13
CG18180
1 of 13
CG18223
1 of 13
CG18420
1 of 13
CG18557
1 of 13
CG18735
1 of 13
CG30002
1 of 13
CG30082
1 of 13
CG30091
1 of 13
CG30187
1 of 13
CG30283
1 of 13
CG30286
1 of 13
CG30287
1 of 13
CG30288
1 of 13
CG30371
1 of 13
CG30414
1 of 13
CG31220
1 of 13
CG32260
1 of 13
CG33225
1 of 13
CG33226
1 of 13
CG33458
1 of 13
CG33459
1 of 13
CG33462
1 of 13
CG33465
1 of 13
CG34295
1 of 13
CG34436
1 of 13
CG34437
1 of 13
CG34457
1 of 13
CG42694
1 of 13
CG43110
1 of 13
CG43742
1 of 13
Corin
1 of 13
ea
1 of 13
flz
1 of 13
grass
1 of 13
Hayan
1 of 13
intr
1 of 13
Jon25Biii
1 of 13
Jon25Bi
1 of 13
Jon65Aii
1 of 13
Jon65Ai
1 of 13
Jon66Cii
1 of 13
Jon66Ci
1 of 13
Jon99Ci
1 of 13
l(2)k05911
1 of 13
mas
1 of 13
MP1
1 of 13
Np
1 of 13
psh
1 of 13
Sb
1 of 13
scaf
1 of 13
Sp7
1 of 13
SPE
1 of 13
Sph35
1 of 13
SPH93
1 of 13
teq
1 of 13
tpr
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PRSS1; serine protease 1
    6 of 14
    276000
    PRSS3; serine protease 3
    6 of 14
    613578
        PRSS2; serine protease 2
        5 of 14
        601564
        KLK3; kallikrein related peptidase 3
        4 of 14
        176820
            KLK11; kallikrein related peptidase 11
            4 of 14
            604434
              KLK14; kallikrein related peptidase 14
              4 of 14
              606135
                  KLK15; kallikrein related peptidase 15
                  4 of 14
                  610601
                      PRSS3P2; PRSS3 pseudogene 2
                      4 of 14
                          KLK1; kallikrein 1
                          3 of 14
                          147910
                            KLK2; kallikrein related peptidase 2
                            3 of 14
                            147960
                                KLK4; kallikrein related peptidase 4
                                3 of 14
                                603767
                                KLK5; kallikrein related peptidase 5
                                3 of 14
                                605643
                                    KLK6; kallikrein related peptidase 6
                                    3 of 14
                                    602652
                                        KLK8; kallikrein related peptidase 8
                                        3 of 14
                                        605644
                                            KLK9; kallikrein related peptidase 9
                                            3 of 14
                                            605504
                                                KLK10; kallikrein related peptidase 10
                                                3 of 14
                                                602673
                                                    KLK12; kallikrein related peptidase 12
                                                    3 of 14
                                                    605539
                                                        KLK13; kallikrein related peptidase 13
                                                        3 of 14
                                                        605505
                                                            PRSS38; serine protease 38
                                                            3 of 14
                                                                Functional Complementation Data
                                                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                Interactions
                                                                Summary of Physical Interactions
                                                                Summary of Genetic Interactions
                                                                Interaction Browsers
                                                                Starting gene(s)
                                                                Interaction type
                                                                Interacting gene(s)
                                                                Reference
                                                                Starting gene(s)
                                                                Interaction type
                                                                Interacting gene(s)
                                                                Reference
                                                                External Data
                                                                Linkouts
                                                                DroID - A comprehensive database of gene and protein interactions.
                                                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                Pathways
                                                                Signaling Pathways (FlyBase)
                                                                Metabolic Pathways
                                                                FlyBase
                                                                External Links
                                                                External Data
                                                                Linkouts
                                                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                Class of Gene
                                                                Genomic Location and Detailed Mapping Data
                                                                Chromosome (arm)
                                                                2R
                                                                Recombination map
                                                                2-64
                                                                Cytogenetic map
                                                                47F4-47F4
                                                                Sequence location
                                                                FlyBase Computed Cytological Location
                                                                Cytogenetic map
                                                                Evidence for location
                                                                47F4-47F4
                                                                Limits computationally determined from genome sequence between P{lacW}Fppsk06103&P{lacW}Fppsk03514 and P{lacW}Tapδk17005&P{lacW}k05103
                                                                Experimentally Determined Cytological Location
                                                                Cytogenetic map
                                                                Notes
                                                                References
                                                                47D-47F
                                                                (determined by in situ hybridisation)
                                                                (Davis et al., 1985)
                                                                Experimentally Determined Recombination Data
                                                                Location

                                                                2-64

                                                                (FlyBase, 2016)

                                                                2-64.2

                                                                (Comeron et al., 2012)
                                                                Left of (cM)
                                                                Right of (cM)
                                                                Notes
                                                                Stocks and Reagents
                                                                Stocks (1)
                                                                Genomic Clones (12)
                                                                 

                                                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                cDNA Clones (179)
                                                                 

                                                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                cDNA clones, fully sequenced
                                                                BDGP DGC clones
                                                                Other clones
                                                                Drosophila Genomics Resource Center cDNA clones

                                                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                cDNA Clones, End Sequenced (ESTs)
                                                                BDGP DGC clones
                                                                Other clones
                                                                RNAi and Array Information
                                                                Linkouts
                                                                DRSC - Results frm RNAi screens
                                                                Antibody Information
                                                                Laboratory Generated Antibodies
                                                                 
                                                                Commercially Available Antibodies
                                                                 
                                                                Cell Line Information
                                                                Publicly Available Cell Lines
                                                                 
                                                                  Other Stable Cell Lines
                                                                   
                                                                    Other Comments

                                                                    New annotation (CG30028) in release 3 of the genome annotation.

                                                                    (FlyBase Genome Annotators, 2002-2003)

                                                                    A clustered gene family (αTry, βTry, γTry and δTry) encoding trypsin-like enzymes has been cloned.

                                                                    (Davis et al., 1985)

                                                                    One of a cluster of trypsin-encoding genes.

                                                                    Relationship to Other Genes
                                                                    Source for database merge of

                                                                    Source for merge of: γTry BcDNA:RE40325

                                                                    (FlyBase, 1996-)
                                                                    Additional comments

                                                                    The CG30028, CG30031 and CG12351 genes encode identical proteins.

                                                                    (Lipinszki et al., 2013)

                                                                    Source for merge of γTry BcDNA:RE40325 was a shared cDNA ( date:030728 ).

                                                                    (FlyBase, 1996-)
                                                                    Nomenclature History
                                                                    Source for database identify of
                                                                    Nomenclature comments
                                                                    Etymology
                                                                    Synonyms and Secondary IDs (17)
                                                                    Datasets (0)
                                                                    Study focus (0)
                                                                    Experimental Role
                                                                    Project
                                                                    Project Type
                                                                    Title
                                                                    Study result (0)
                                                                    Result
                                                                    Result Type
                                                                    Title
                                                                    External Crossreferences and Linkouts ( 38 )
                                                                    Sequence Crossreferences
                                                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                    Other crossreferences
                                                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                    FlyMine - An integrated database for Drosophila genomics
                                                                    InterPro - A database of protein families, domains and functional sites
                                                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                    MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
                                                                    Linkouts
                                                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                    DroID - A comprehensive database of gene and protein interactions.
                                                                    DRSC - Results frm RNAi screens
                                                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                    References (38)