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Gene Dmel\Akt1

General Information
Symbol	Dmel\Akt1	Species	D. melanogaster
Name	Akt1	Annotation symbol	CG4006
Feature type	protein_coding_gene	FlyBase ID	FBgn0010379
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	AKT, dAkt, dAkt1, PKB, dPKB, Akt/PKB, l(3)04226, PKB/AKT, RAC, dAkt/PKB
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89B3-89B3	Sequence location	3R:11,924,938..11,930,239 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Akt1 is referred to in FlyBase by the symbol Dmel\Akt1 (CG4006, FBgn0010379). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity; protein kinase activity. There is experimental evidence for 14 unique biological process terms, many of which group under: biological regulation; regulation of biological process; anatomical structure development; macromolecule modification; cellular component organization or biogenesis; localization; regulation of developmental process; positive regulation of biological process; regulation of cellular component organization; protein modification process; negative regulation of neurological system process; lipid storage; chitin-based cuticle development; open tracheal system development; regulation of apoptosis; regulation of multicellular organismal development; response to hormone stimulus. 32 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; external compound sense organ; adult mesothoracic segment; thoracic segment; organ system; compound cell cluster organ; gland; wing hair; dorsal thoracic disc; primordium; synapse. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Pleckstrin homology domain; Pleckstrin homology-type; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639064_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Akt1. Gene sequence location is 3R:11924938..11930239.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Willecke et al., 2011, Oncogene 30(39): 4067--4074 Sequence features BKN50987 HFA14108 BKN20591 BKN50056
FB2011_10	References Bjedov et al., 2010, Cell Metab. 11(1): 35--46 Controlled Vocabulary Terms long term synaptic depression
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B3-89B3   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89B-89C     (Franke, 1993.9.9) 89B6-89B7   (determined by in situ hybridisation)   (Spradling et al., 1999) 89B6-89B7   (determined by in situ hybridisation)   (Perrimon et al., 1996) 89B4-89B10   (determined by in situ hybridisation)   (Andjelkovic et al., 1995) 89B6-89B7     (BDGP Project Members, 1994-1999) 89B-89C   (determined by in situ hybridisation)   (Franke et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Akt1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_non_canonical_start_codon ; SO:0001739 Unconventional translation start (ACG) postulated; FBrf0079853.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Akt1-RA FBtr0083227  NM_169706   3728   530 Akt1-RB FBtr0083226  NM_169707   3663   530 Akt1-RC FBtr0083228  NM_169705   3663   611
Additional Transcript Data & Comments
Reported size (kB)	4.0, 2.8 (northern blot) (Franke et al., 1994) 3.9, 2.7 (northern blot) (Andjelkovic et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Akt1-PA   FBpp0082681   59.9   530   5.67     NP_732114   AAF55275 Akt1-PB   FBpp0082680   59.9   530   5.67     NP_732115   AAF55276 Akt1-PC   FBpp0082682   68.5   611   6.17     NP_732113   AAN13699
Additional Polypeptide Data & Comments
Reported size (kDa)	611, 530 (aa); 60 (kD predicted) (Andjelkovic et al., 1995) 530 (aa) (Franke et al., 1994)
Comments	The 611aa form of Akt1 protein is a minor form apparently produced from translation from a weaker ACG upstream of the AUG. (Andjelkovic et al., 1995) Three different size Akt1 protein species of 66, 85, and 120kD are observed on western blots. The 66kD species is most prominent and is detected at all stages with the highest levels in embryos and pupae. The 85kD species is similarly expressed though at a lower level but is not detected in larvae. The 120kD species is detected mainly in early embryos and early pupae. (Andjelkovic et al., 1995)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Pleckstrin homology domain (IPR001849) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Pleckstrin homology-type (IPR011993) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, C-terminal (IPR017892)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695799   AE014297 AAF55275   AE014297 AAF55276   AE014297 AAN13699   AI259065   AI515251   AI534097   AI543577   AQ026195   AW944630   AY069856 AAL40001   BI164072   BI215600   BI216398   BI235802   BI242340   BI366625   BI372013   BI484229   BX009222   CA807524   CK661538   CL705848   CO177033   CO189005   CO189743   CO191219   CO195750   CO263584   CO263875   CO264096   CO264097   CO264098   CO265294   CO265296   CO265298   CO265308   CO265309   CO265311   CO265312   CO265314   CO265315   CO265317   CO265318   CO265319   CO265320   CO265321   CO265322   CO265323   CO265324   CO265325   CO265326   CO266113   CO266790   CO266792   CO266794   CO266796   CO273478   CO275939   CO279170   CO280200   CO280201   CO280320   CO281620   CO284383   CO287134   CO293352   CO297452   CO297946   CO313864   CO319034   CO322268   CO328328   CO328957   CO332374   CO332476   CO333623   CO335830   CO338146   CO340370   CO344168   CO344553   CZ467679   EC053041   EC054020   EC055431   EC055452   EC058225   EC058229   EC060055   EC061970   EC069350   EC071564   EC072322   EC073323   EC077880   EC078481   EC081074   EC082918   EC082974   EC087361   EC090853   EC195451   EC196873   EC198041   EC199923   EC201251   EC206829   EC206830   EC208251   EC208977   EC211895   EC216744   EC218183   EC218510   EC221879   EC224321   EC225515   EC227832   EC232020   EC232489   EC237278   EC237392   EC237466   EC241227   EC242723   EC243382   EC243441   EC243443   EC247364   EC248292   EC253869   EC255414   EC259266   EC263177   EC267085   EV577800   EV582801   GH941200   GH944093   GH944690   GH945914   GH946562   GH950002   GH955492   GH956117   GH956918   GH957761   GH962132   GH962334   GH963504   GH963608   GH963631   GH964276   GH964781   GH965553   GH967777   GH968440   GH968614   GH969415   GH970462   GH970638   GH972469   GH974329   GH974647   GH976026   GH976542   GH976556   GH976894   GH977347   GH977929   GH979826   GH980277   GH980523   GH980550   GH982209   GH982650   GH983418   GH984910   X83510 CAA58499   X83510 CAA58500   Z26242 CAA81204
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8INB9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Andjelkovic et al., 1995)   (Franke et al., 1994) embryonic stage | early     (Andjelkovic et al., 1995) embryonic stage -- adult stage     (Andjelkovic et al., 1995) pupal stage     (Franke et al., 1994) adult stage | female     (Andjelkovic et al., 1995) adult stage & oogenesis   nurse cell   (Andjelkovic et al., 1995)
Additional Descriptive Data
	Akt1 transcripts are detected in embryo RNA and weakly in pupal RNA. (Franke et al., 1994) The 4kb Akt1 transcripts are detected throughout embryogenesis and larval stages on northern blots. They are also detected in pupal stages and in adult females. Akt1 transcripts are uniformly distributed at a high level in embryos and are observed in nurse cells during oogenesis. (Andjelkovic et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Andjelkovic et al., 1995) embryonic stage -- adult stage     (Andjelkovic et al., 1995)
Additional Descriptive Data
	Akt1 protein is detected in extracts from early embryos, adults, and S2 cells by Western blot. By immunolocalization, Akt1 protein is found to be uniformly distributed in embryos. (Andjelkovic et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010379    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010379 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010379 expression level Developmental Stage   Expression Level embryo 00-02hr    3224 embryo 02-04hr    1854 embryo 04-06hr    2872 embryo 06-08hr    3158 embryo 08-10hr    2820 embryo 10-12hr    3044 embryo 12-14hr    2509 embryo 14-16hr    1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6    1909 larva L3 puffstage 7-9    2603 white prepupae new    2661 white prepupae 12hr    2822 white prepupae 24hr    2298 pupae 2d postWPP    1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day    1504 adult female 05day    2323 adult female 30day    2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3224) embryo 02-04hr  (1854) embryo 04-06hr  (2872) embryo 06-08hr  (3158) embryo 08-10hr  (2820) embryo 10-12hr  (3044) embryo 12-14hr  (2509) embryo 14-16hr  (1594) embryo 16-18hr  (1379) embryo 18-20hr  (1169) embryo 20-22hr  (1074) embryo 22-24hr  (1286) larva L1  (918) larva L2  (972) larva L3 12hr old  (818) larva L3 puffstage 1-2  (849) larva L3 puffstage 3-6  (1909) larva L3 puffstage 7-9  (2603) white prepupae new  (2661) white prepupae 12hr  (2822) white prepupae 24hr  (2298) pupae 2d postWPP  (1891) pupae 3d postWPP  (1247) pupae 4d postWPP  (1301) adult male 01day  (1113) adult male 05day  (1137) adult male 30day  (1123) adult female 01day  (1504) adult female 05day  (2323) adult female 30day  (2471) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3224) embryo 02-04hr  (1854) embryo 04-06hr  (2872) embryo 06-08hr  (3158) embryo 08-10hr  (2820) embryo 10-12hr  (3044) embryo 12-14hr  (2509) embryo 14-16hr  (1594) embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6  (1909) larva L3 puffstage 7-9  (2603) white prepupae new  (2661) white prepupae 12hr  (2822) white prepupae 24hr  (2298) pupae 2d postWPP  (1891) pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day  1504 adult female 05day  (2323) adult female 30day  (2471) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3224 embryo 02-04hr    1854 embryo 04-06hr    2872 embryo 06-08hr    3158 embryo 08-10hr    2820 embryo 10-12hr    3044 embryo 12-14hr    2509 embryo 14-16hr    1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6    1909 larva L3 puffstage 7-9    2603 white prepupae new    2661 white prepupae 12hr    2822 white prepupae 24hr    2298 pupae 2d postWPP    1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day    1504 adult female 05day    2323 adult female 30day    2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3224 embryo 02-04hr    1854 embryo 04-06hr    2872 embryo 06-08hr    3158 embryo 08-10hr    2820 embryo 10-12hr    3044 embryo 12-14hr    2509 embryo 14-16hr    1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6    1909 larva L3 puffstage 7-9    2603 white prepupae new    2661 white prepupae 12hr    2822 white prepupae 24hr    2298 pupae 2d postWPP    1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day    1504 adult female 05day    2323 adult female 30day    2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010379 expression level Developmental Stage   Expression Level embryo 00-02hr    3224 embryo 02-04hr    1854 embryo 04-06hr    2872 embryo 06-08hr    3158 embryo 08-10hr    2820 embryo 10-12hr    3044 embryo 12-14hr    2509 embryo 14-16hr    1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6    1909 larva L3 puffstage 7-9    2603 white prepupae new    2661 white prepupae 12hr    2822 white prepupae 24hr    2298 pupae 2d postWPP    1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day    1504 adult female 05day    2323 adult female 30day    2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3224) embryo 02-04hr  (1854) embryo 04-06hr  (2872) embryo 06-08hr  (3158) embryo 08-10hr  (2820) embryo 10-12hr  (3044) embryo 12-14hr  (2509) embryo 14-16hr  (1594) embryo 16-18hr  (1379) embryo 18-20hr  (1169) embryo 20-22hr  (1074) embryo 22-24hr  (1286) larva L1  (918) larva L2  (972) larva L3 12hr old  (818) larva L3 puffstage 1-2  (849) larva L3 puffstage 3-6  (1909) larva L3 puffstage 7-9  (2603) white prepupae new  (2661) white prepupae 12hr  (2822) white prepupae 24hr  (2298) pupae 2d postWPP  (1891) pupae 3d postWPP  (1247) pupae 4d postWPP  (1301) adult male 01day  (1113) adult male 05day  (1137) adult male 30day  (1123) adult female 01day  (1504) adult female 05day  (2323) adult female 30day  (2471) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3224) embryo 02-04hr  1854 embryo 04-06hr  (2872) embryo 06-08hr  (3158) embryo 08-10hr  (2820) embryo 10-12hr  (3044) embryo 12-14hr  (2509) embryo 14-16hr  1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6  1909 larva L3 puffstage 7-9  (2603) white prepupae new  (2661) white prepupae 12hr  (2822) white prepupae 24hr  2298 pupae 2d postWPP  1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day  1504 adult female 05day  2323 adult female 30day  2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3224 embryo 02-04hr    1854 embryo 04-06hr    2872 embryo 06-08hr    3158 embryo 08-10hr    2820 embryo 10-12hr    3044 embryo 12-14hr    2509 embryo 14-16hr    1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6    1909 larva L3 puffstage 7-9    2603 white prepupae new    2661 white prepupae 12hr    2822 white prepupae 24hr    2298 pupae 2d postWPP    1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day    1504 adult female 05day    2323 adult female 30day    2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3224 embryo 02-04hr    1854 embryo 04-06hr    2872 embryo 06-08hr    3158 embryo 08-10hr    2820 embryo 10-12hr    3044 embryo 12-14hr    2509 embryo 14-16hr    1594 embryo 16-18hr    1379 embryo 18-20hr    1169 embryo 20-22hr    1074 embryo 22-24hr    1286 larva L1    918 larva L2    972 larva L3 12hr old    818 larva L3 puffstage 1-2    849 larva L3 puffstage 3-6    1909 larva L3 puffstage 7-9    2603 white prepupae new    2661 white prepupae 12hr    2822 white prepupae 24hr    2298 pupae 2d postWPP    1891 pupae 3d postWPP    1247 pupae 4d postWPP    1301 adult male 01day    1113 adult male 05day    1137 adult male 30day    1123 adult female 01day    1504 adult female 05day    2323 adult female 30day    2471 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010379    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010379 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010379 expression level Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland    756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland  (756.1) Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland    756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland    756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010379 expression level Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland    756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland  756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland    756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    498.75 Larval Midgut    202.8 Larval Hindgut    282.9 Larval Malpighian Tubules    321 Larval Fat Body    431.5 Larval Salivary Gland    756.1 Larval Trachea    192.925 Larval Carcass    353.475 Adult Head    163.4 Adult Eye    118.775 Adult Brain    105.7 Adult Thoracic-Abdominal Ganglion    152.7 Adult Crop    362.5 Adult Midgut    195.8 Adult Hindgut    319.4 Adult Malpighian Tubules    41.2 Adult Fat Body    498.1 Adult Salivary Gland    212.4 Adult Heart    244.95 Adult VirginFemale Spermatheca    305.8 Adult InseminatedFemale Spermatheca    341.7 Adult Ovary    173.7 Adult Testis    36.5 Adult Male Accessory Gland    351.7 Adult Carcass    251.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    163.4   NA  Eye    118.775   NA  Brain    105.7   498.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    152.7   NA  Crop    362.5   202.8  Midgut    195.8   282.9  Hindgut    319.4   321  Malpighian Tubules    41.2   431.5  Fat Body    498.1   756.1  Salivary Gland    212.4   NA  Heart    244.95   192.925  Trachea    NA   NA  VirginFemale Spermatheca    305.8   NA  InseminatedFemale Spermatheca    341.7   NA  Ovary    173.7   NA  Testis    36.5   NA  Male Accessory Gland    351.7   353.475  Carcass    251.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010379 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4006-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Akt1 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU Akt1GD1361 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH Akt1GD1361 lethal, with Scer\GAL4pnr-MD237 Akt1GD1361 lethal | embryonic stage | germline clone | maternal effect Akt11 lethal | embryonic stage | maternal effect Akt104226 lethal | embryonic stage | maternal effect | recessive Akt11 lethal | larval stage Akt11 lethal | polyphasic | recessive Akt104226 lethal | pupal stage, with Scer\GAL4pnr-MD237 Akt1GD1361 lethal | recessive Akt11 Akt12 Akt104226 semi-lethal Akt104226 semi-lethal | recessive Akt104226 viable Akt13 Akt104226 Sterility Allele female sterile | recessive Akt104226 Other Phenotypes Allele body size defective (with Akt11) Akt104226 body size defective (with Akt104226) Akt11 body size defective | embryonic stage | recessive Akt11 body size defective | pupal stage | recessive Akt11 body size defective | recessive Akt11 cell death defective | embryonic stage | maternal effect | recessive Akt11 cell size defective | recessive | somatic clone Akt11 chemical resistant, with Scer\GAL4elav-C155 Akt1EY10012 Akt1KK100495 chemical sensitive, with Scer\GAL4elav-C155 Akt1Scer\UAS.Exel decreased cell death, with Scer\GAL4hs.PB Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 decreased cell number, with Scer\GAL4nub-AC-62 Akt1GD1361 decreased cell size Akt104226 decreased cell size, with Scer\GAL4nub-AC-62 Akt1GD1361 decreased cell size | somatic clone Akt11 hyperplasia, with Scer\GAL4GMR.PF Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 increased cell death | germline clone Akt11 increased cell size, with Scer\GAL4en-e16E Akt1Scer\UAS.Exel Akt1Scer\UAS.T:Ivir\HA1 increased cell size, with Scer\GAL4GMR.PF Akt1Scer\UAS.T:Ivir\HA1 increased cell size | somatic clone, with Scer\GAL4Act5C.PP Akt1Scer\UAS.T:Ivir\HA1 neuroanatomy defective Akt104226 neuroanatomy defective, with Scer\GAL4da.G32 Akt1Scer\UAS.cRa neuroanatomy defective | larval stage, with Scer\GAL4ppk.PG Akt1GD1361 Akt1Scer\UAS.Exel neuroanatomy defective | larval stage | somatic clone Akt1unspecified neurophysiology defective | recessive | third instar larval stage Akt104226 neurophysiology defective | third instar larval stage, with Akt11 Akt1hs.PS neurophysiology defective | third instar larval stage, with Akt1hs.PS Akt11 neurophysiology defective | third instar larval stage (with Akt11) Akt104226 neurophysiology defective | third instar larval stage (with Akt104226) Akt11 planar polarity defective, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1 size defective, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1 size defective, with Scer\GAL4GMR.PF Akt1Scer\UAS.T:Ivir\HA1 size defective, with Scer\GAL4nub-AC-62 Akt1GD1361 small body Akt13 Akt104226 small body | recessive Akt13 Akt104226 visible Akt1T342D.S505D.GMR visible, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4ap-md544 Akt1Scer\UAS.Exel visible, with Scer\GAL4Bx-MS1096 Akt1Scer\UAS.Exel visible, with Scer\GAL4dpp.blk1 Akt1Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4GMR.PF Akt1Scer\UAS.cRa Akt1Scer\UAS.cSa Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 Akt1Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4hs.2sev Akt1Scer\UAS.T:Ivir\HA1 visible | recessive Akt11 visible | recessive | somatic clone Akt11 visible | somatic clone Akt11 wild-type Akt1hs.PS Phenotype manifest in Allele 1st posterior cell, with Scer\GAL4dpp.blk1 Akt1Scer\UAS.T:Ivir\HA1 dendrite | larval stage, with Scer\GAL4ppk.PG Akt1GD1361 Akt1Scer\UAS.Exel dendrite | larval stage | somatic clone Akt1unspecified embryo Akt11 embryonic/first instar larval cuticle | germline clone | maternal effect Akt11 embryonic/first instar larval cuticle | maternal effect Akt104226 embryonic/larval salivary gland, with Scer\GAL4fkh.PH Akt1Scer\UAS.T:Ivir\HA1 embryonic/larval salivary gland, with Scer\GAL4hs.PB Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 eye Akt11 Akt1T342D.S505D.GMR eye, with Scer\GAL4GMR.long Akt1Scer\UAS.Exel eye, with Scer\GAL4GMR.PF Akt1Scer\UAS.T:Ivir\HA1 Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 Akt1Scer\UAS.cRa Akt1Scer\UAS.cSa eye, with Scer\GAL4hs.2sev Akt1Scer\UAS.T:Ivir\HA1 eye | somatic clone Akt11 head capsule | somatic clone Akt11 interommatidial bristle, with Scer\GAL4GMR.PF Akt1Scer\UAS.T:Ivir\HA1 neuromuscular junction | third instar larval stage, with Akt11 Akt1hs.PS neuromuscular junction | third instar larval stage, with Akt1hs.PS Akt11 neuromuscular junction | third instar larval stage (with Akt11) Akt104226 neuromuscular junction | third instar larval stage (with Akt104226) Akt11 ommatidium Akt1T342D.S505D.GMR ommatidium, with Scer\GAL4GMR.PF Akt1Scer\UAS.T:Ivir\HA1 Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 Akt1Scer\UAS.cSa ommatidium (with Akt11) Akt13 ommatidium (with Akt13) Akt11 ommatidium | somatic clone Akt11 rhabdomere | somatic clone Akt11 synapse Akt104226 synapse | supernumerary, with Scer\GAL4da.G32 Akt1Scer\UAS.cRa tracheal branch primordium Akt11 tracheal branch primordium (with Df(3R)sbd45) Akt11 wing, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1 wing, with Scer\GAL4Bx-MS1096 Akt1GD1361 Akt1Scer\UAS.Exel wing, with Scer\GAL4dpp.blk1 Akt1Scer\UAS.T:Ivir\HA1 wing, with Scer\GAL4nub-AC-62 Akt1GD1361 wing | posterior, with Scer\GAL4en-e16E Akt1Scer\UAS.Exel wing blade, with Scer\GAL4ap-md544 Akt1Scer\UAS.Exel wing disc, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1 wing disc | posterior compartment, with Scer\GAL4en-e16E Akt1Scer\UAS.T:Ivir\HA1 wing disc | somatic clone, with Scer\GAL4Act5C.PP Akt1Scer\UAS.T:Ivir\HA1 wing hair, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1 wing hair | somatic clone Akt11 wing margin bristle | somatic clone, with Scer\GAL4Act5C.PI Akt1Scer\UAS.T:Ivir\HA1 wing vein, with Scer\GAL471B Akt1Scer\UAS.T:Ivir\HA1
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Akt1 Class Mutagen Stocks Known lesion Akt104226 hypomorphic allele - genetic evidence P-element activity 1 Yes Akt1c02098 piggyBac transposase 1 -- Akt1EY10012 P-element activity 1 -- Akt11 loss of function allele 0 Yes Akt12 ethyl methanesulfonate 0 -- Akt13 hypomorphic allele - genetic evidence 0 Yes Akt16M4 0 -- Akt19 0 -- Akt1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Akt1 Class Mutagen Stocks Known lesion Akt1GMR.Exel in vitro construct - regulatory fusion 2 Yes Akt1Scer\UAS.Exel in vitro construct - regulatory fusion 2 Yes Akt1T342D.S505D.GMR in vitro construct - amino acid replacement 2 Yes Akt1GD1361 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Akt1HM04007 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Akt1HMS00007 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Akt1KK100495 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Akt1Act5C.T:Myr1 in vitro construct - regulatory fusion 0 Yes Akt1Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Akt1dsRNA.cPa in vitro construct - RNAi 0 Yes Akt1dsRNA.cSa in vitro construct - RNAi 0 Yes Akt1hs.PS in vitro construct - regulatory fusion 0 Yes Akt1hs.PV in vitro construct - regulatory fusion 0 Yes Akt1hs.T:Uuuu\Myr4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Akt1K214M.hs in vitro construct - regulatory fusion 0 Yes Akt1R45A.tub in vitro construct - amino acid replacement 0 Yes Akt1S505A.tub in vitro construct - amino acid replacement 0 Yes Akt1Scer\UAS.cRa in vitro construct - regulatory fusion 0 Yes Akt1Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Akt1Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Akt1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Akt1T342A.tub in vitro construct - amino acid replacement 0 Yes Akt1tub.PH in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7328 (Ryder, 2004.4.26) Df(3R)pnrD4R+3 (Heitzler et al., 1996) Df(3R)sbd45 (Staveley et al., 1998, Heitzler et al., 1996) Df(3R)sbd105 (Spradling et al., 1999) Tp(3;3)sbd104 (Heitzler et al., 1996)
Not disrupted in	Df(3R)bxd100 (BDGP Project Members, 1994-1999) Df(3R)E8-89B-Rev2 (Heitzler et al., 1996) Df(3R)sbd26 (Heitzler et al., 1996)
Duplicated in	Dp(3;3)BK43 (Heitzler et al., 1996) Dp(3;3)BK44 (Heitzler et al., 1996)
Not duplicated in	Ts(1Rt;3Rt)OR60+Ts(1Lt;3Lt)89Bq2 (Heitzler et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1361} NA P{KK100495} NA P{TRiP.HM04007} NA P{TRiP.HMS00007} NA P{UAS-Akt1.Exel} NA P{UAS-Akt1.HA} NA P{UAS-Akt1.R} NA P{UAS-Akt1.S} NA P{UAS-myr-Akt1.S} NA heat-shock construct P{hs-Akt1.S} NA characterization construct P{GMR-Akt1.Exel} NA P{GMR-Akt1.T342D.S505D} NA P{tub-Akt1.H} NA P{UAS-Akt1.R45A} NA P{UAS-Akt1.S505A} NA P{UAS-Akt1.T342A} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Akt1EY10012 NA miscellaneous insertions PBac{PB}Akt1c02098 NA insertion of enhancer trap P{PZ}Akt104226 No
Gene Ontology: Function, Process & Cellular Component ( 25 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
protein kinase activity inferred from direct assay (Andjelkovic et al., 1995) protein serine/threonine kinase activity inferred from direct assay (assigned by UniProtKB) (Potter et al., 2002) inferred from mutant phenotype (Staveley et al., 1998)
Biological Process
CV term Evidence References
anti-apoptosis inferred from mutant phenotype (Staveley et al., 1998) chitin-based embryonic cuticle biosynthetic process inferred from genetic interaction with Pi3K21B (Jin et al., 2001) insulin receptor signaling pathway inferred from genetic interaction with UniProtKB:P91634 (assigned by UniProtKB) (Scanga et al., 2000) intracellular signal transduction inferred from genetic interaction with UniProtKB:P91634 (assigned by UniProtKB) (Scanga et al., 2000) lipid storage inferred from genetic interaction with Pten (Vereshchagina and Wilson, 2006) long term synaptic depression inferred from mutant phenotype (Guo and Zhong, 2006) open tracheal system development inferred from mutant phenotype (Jin et al., 2001) positive regulation of cell growth inferred from mutant phenotype (assigned by UniProtKB) (Cavaliere et al., 2005, Scanga et al., 2000, Potter et al., 2002) positive regulation of cell size inferred from mutant phenotype (Verdu et al., 1999, Scanga et al., 2000) positive regulation of organ growth inferred from mutant phenotype (Scanga et al., 2000) protein phosphorylation inferred from direct assay (assigned by UniProtKB) (Potter et al., 2002) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) regulation of dendrite development inferred from mutant phenotype (Parrish et al., 2009) regulation of multicellular organism growth inferred from mutant phenotype (Scanga et al., 2000)
Cellular Component
CV term Evidence References
cell surface inferred from direct assay (Vereshchagina and Wilson, 2006) cytoplasm inferred from direct assay (Vereshchagina and Wilson, 2006)
Terms Based on Predictions or Assertions ( 15 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR017892 (FlyBase Curators et al., 2004-) phosphatidylinositol binding non-traceable author statement (Oldham and Hafen, 2003) protein serine/threonine kinase activity inferred from sequence or structural similarity (Andjelkovic et al., 1995) non-traceable author statement (Franke, 1993.9.9, Hemmnings, 1994.12.14, Morrison et al., 2000)
Biological Process
CV term Evidence References
insulin receptor signaling pathway non-traceable author statement (Johnston and Gallant, 2002) traceable author statement (Claeys et al., 2002) open tracheal system development traceable author statement (Davies, 2002, Ghabrial et al., 2003) positive regulation of cell growth non-traceable author statement (Johnston and Gallant, 2002) traceable author statement (Weinkove and Leevers, 2000, Oldham and Hafen, 2003) positive regulation of cell size non-traceable author statement (Potter and Xu, 2001) traceable author statement (Oldham et al., 2000, Jacinto and Hall, 2003) positive regulation of multicellular organism growth traceable author statement (Weinkove and Leevers, 2000, Oldham et al., 2000, Oldham and Hafen, 2003) positive regulation of organ growth non-traceable author statement (Potter and Xu, 2001) traceable author statement (Oldham and Hafen, 2003, Hafen and Stocker, 2003) protein phosphorylation non-traceable author statement (Morrison et al., 2000) regulation of cell size non-traceable author statement (Claeys et al., 2002) regulation of multicellular organism growth non-traceable author statement (Claeys et al., 2002) regulation of organ growth non-traceable author statement (Weinkove and Leevers, 2000, Claeys et al., 2002) regulation of protein import into nucleus traceable author statement (Ghabrial et al., 2003)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (Oldham and Hafen, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Akt1 allele Gene References Akt11 foxo (Junger et al., 2003) Pdk1 (Rintelen et al., 2001) Pi3K92E (Radimerski et al., 2002) Pten (Stocker et al., 2002, Lee et al., 2003) trh (Jin et al., 2001) Tsc1 (Gao and Pan, 2001) Akt13 Pi3K92E (Radimerski et al., 2002) Pten (Stocker et al., 2002, Lee et al., 2003) Akt104226 Pten (Gao et al., 2000, Stocker et al., 2002) Akt1Scer\UAS.cRa Pdk1 (Rintelen et al., 2001, Reiling and Hafen, 2004, Reiling et al., 2005) Pi3K92E (Radimerski et al., 2002) S6k (Radimerski et al., 2002) Akt1Scer\UAS.cSa foxo (Kramer et al., 2003) Akt1Scer\UAS.T:Ivir\HA1 foxo (Puig et al., 2003) gig (Potter et al., 2002) Pdk1 (Cho et al., 2001) Thor (Miron et al., 2001) unspecified foxo (Goberdhan et al., 2005) Pten (Kiger et al., 2003) Thor (Junger et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67008 DroID - A comprehensive database of gene and protein interactions. • FBgn0010379 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41957
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16155 Dere\GG16978 Dgri\GH18765 Dmoj\GI22655 Dper\GL12220 Dpse\GA17848 Dsec\GM24284 Dsim\GD19074 Dvir\GJ23383 Dwil\GK13262 Dyak\GE24369
Curated drosophilid orthologs	Dmau\Akt1 (Tao et al., 2003, Tao et al., 2003) Dpse\GA17848   Dsim\Akt1 (Tao et al., 2003, Tao et al., 2003)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008823-PA Aedes aegypti (mosquito) XP_396874.3 Apis mellifera (honey bee) XP_001951736.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008304-PA Bombyx mori (silk worm) ENSBTAP00000001839 Bos taurus (bovine) CN29052 Caenorhabditis brenneri (small nematode) CBP27393 Caenorhabditis briggsae (nematode) CE05274 Caenorhabditis elegans (worm) ENSCAFP00000008032 Canis familiaris (dog) ENSCAFP00000023241 Canis familiaris (dog) ENSCINP00000016460 Ciona intestinalis (sea squirt) cn10239 Cryptococcus neoformans (yeast-like fungus) CPIJ007754 Culex pipens (mosquito) ENSCPOP00000010642 Cavia porcellus (guinea pig) RP17681 Caenorhabditis remanei (nematode) ENSCSAVP00000013099 Ciona savignyi (sedentary tunicate) DDB0191195 Dictyostelium discoideum (amoeba) 299642 Daphnia pulex (daphnia) ENSDARP00000087032 Danio rerio (zebra fish) ENSECAP00000017503 Equus caballus (horse) XP_655136 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000026547 Gymnopilus aculeatus (mushroom) ENSGALP00000036651 Gallus gallus (chicken) 119785 Hypsipyla robusta (cedar shoot borer) ENSP00000263826 Homo sapiens (human) ISCW018284-PA Ixodes scapularis (deer tick) 181288 Lottia gigantea (owl limpet) 34933 Monocosta brevicollis (choanoflagellate) ENSMODP00000008221 Monodelphis domestica (gray opossum) ENSMMUP00000026292 Macaca mulatta (rhesus monkey) ENSMUSP00000106790 Mus musculus (house mouse) 115630 Nematostella vectensis (starlet anemone) XP_001605990.1 Nasonia vitripennis (wasp) ENSOANP00000016282 Ornithorynchus anatinus (platypus) ENSORLP00000006529 Oryzias latipes (japanese killifish) PHUM001973-PA Pediculus humanus (human body louse) ENSPPYP00000000057 Pongo pygmaeus (orangutan) ENSPTRP00000050982 Pan troglodytes (chimpanzee) ENSRNOP00000025303 Rattus norvegicus (norway rat) Smp_073930.2 Schistosoma mansoni (trematode parasite) XP_787246.2 Strongylocentrotus purpuratus (purple sea urchin) 51134 Trichoplax adhaerens (metazoa) Tc00.1047053508965.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509007.60 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007984 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021654 Takifugu rubripes (pufferfish Takifugu) 3809.m00209 Tetrahymena thermophila (ciliate protozoa) 90981.m00083 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037022 Xenopus tropicalis (frog) YALI0E06501g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10151 ISCW018284 FBgn0241490 FBgn0215271 FBgn0215269 FBgn0210484 FBgn0190581 FBgn0179148 JGI_V11_299642 FBgn0077857 FBgn0149827 FBgn0145383 FBgn0126232 FBgn0109206 FBgn0093177 CPIJ007754 BGIBMGA008304 ACYPI002231 GB15685 AGAP002161 AAEL008823 PHUM299490 GLEAN_07749
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	8191 y1 w1118; P{UAS-Akt1.Exel}2 8192 P{UAS-Akt1.Exel}1, y1 w1118 8195 P{GMR-Akt1.Exel}1, y1 w1118 8196 y1 w1118; P{GMR-Akt1.Exel}2 31701 y1 v1; P{TRiP.HM04007}attP2 33615 y1 v1; P{TRiP.HMS00007}attP2 8193 P{GMR-Akt1.T342D.S505D}1, y1 w1118 8194 y1 w1118; P{GMR-Akt1.T342D.S505D}2 11627 ry506 P{PZ}Akt104226/TM3, ryRK Sb1 Ser1
Harvard	- PBac{PB}Akt1c02098
VDRC	v103703 P{KK100495}VIE-260B v2902 w1118; P{GD1361}v2902
	More stocks available...
Genomic Clones ( 1 )
	BACR05C20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 155 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10374
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM04486 LD46990 LP02388 LP21124 RE03643 RE22157 RE23523 RE31734 RE39641 RE52204 RE56626 RE67295 SD06610
Other clones	11076.2 11138 29080 34851 40411 42643 53587 62434 73528 74447 77045 83257 103678 105277 108115 117430 118623 159835 174954 191385 214245.45 214341.50 214345.30 281981 283691 542776 569998 CK01.52D.B6 CK01.55A.B12 CK01.64B.E1 CK01.64B.E5 CK01.106C.D7 CK01.145A.B1 CK01.167C.F9 Dmel_dig_003363_0643_1826 Dmel_dig_008759_0631_1864 EC30464 EC40883 EC053041 EC054020 EC055431 EC055452 EK042739 EK045038 EK052215 EK065017 EK089016 EK111113 EK119205 EK133704 EK136736 EK137407 EK137410 EK137446 EK142205 EK142208 EK142211 EK142226 EK142227 EK142229 EK142230 EK142232 EK142233 EK142235 EK142236 EK142237 EK142238 EK142240 EK142241 EK142243 EK142244 EK142246 EK142247 EK144954 EK147601 EK147604 EK147607 EK147610 EK153301 EK153302 EK153739 EK157722 EK165934 EK170963 EK187758 EK202631 EK217018 EK234206 EK276040 EK291737 EK303304 EK303601 EK307464 EN11316 EN16039 EP09012 EP10523 EP18761 EP19504 ESG018b.E21.1_E07 RP004050689 RP004069468 RP004085266 RP004095955 RP004177857 RP004210071 RP004218469 RP004219147 RP004223611 RP004223829 RP004238129 RP004239738 RP004240482 RP004242656 RP004243983 RP004247174 RP004266358 RP004269471 RP004294189 RP004307634 RP004316126 RP004316667 RP004328557 RP004359594 RP004365752 RP004396499 RP004424086 RP004426465 RP004441716 RP004452041 RP004454792 RP004463016 RP004490557 RP004500695 RP004507650 RP004512323 RP004513000 RP004513310 RP004515259 RP004526304 RP004527677
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41957
Antibody Information
	polyclonal (Andjelkovic et al., 1995, Lizcano et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Akt1 CG4006 (Li, 1999.11)
Source for database merge of	Source for merge of: Akt1 l(3)04226 (Spradling et al., 1999) Source for merge of: l(3)89Bs Akt1 (Staveley et al., 1998)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a reduction in cell size. (Guertin et al., 2006) dsRNA made from templates generated with primers directed against this gene does not significantly inhibit S6k phosphorylation in S2 cells. (Yang et al., 2006) dsRNA made from templates generated with primers directed against this gene used to treat S2 cells. (Yang et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become retracted (unspread but flat). Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Data implicates Akt1 as a cell survival gene. (Staveley et al., 1998) Mutants exhibit ectopic apoptosis during embryogenesis as judged by induction of membrane blebbing, DNA fragmentation and macrophage infiltration. Apoptosis caused by loss of Akt1 function is rescued by caspase suppression. (Staveley et al., 1998) Btau\AKT1 is effective at rescuing Akt1 mutants, demonstrating Akt1 is as functional homolog of Btau\AKT1. (Staveley et al., 1998) Complementation group identified during genetic analysis of the pnr region. (Heitzler et al., 1996) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996) Akt1 has been cloned and sequenced. (Franke et al., 1994, Andjelkovic et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169705 NM_169706 NM_169707 RefSeq (Proteins) • NP_732113 NP_732114 NP_732115 DDBJ / EMBL / GenBank • AA695799 AAF55275 AAF55276 AAL40001 AAN13699 AI543577 AQ026195 AW944630 AY069856 CAA58499 CAA58500 CAA81204 CL705848 CZ467679 X83510 Z26242 Entrez Gene - A searchable database of RefSeq genes. • 41957 UniProtKB/TrEMBL • Q8INB9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Pleckstrin homology domain (IPR001849) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Pleckstrin homology-type (IPR011993) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, C-terminal (IPR017892)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67008 DroID - A comprehensive database of gene and protein interactions. • FBgn0010379 DRSC - Results from RNAi screens. • FBgn0010379 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010379 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4006-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41957 InParanoid A subset of ortholog calls from InParanoid. • AAEL008823-PA Aedes aegypti (mosquito) XP_396874.3 Apis mellifera (honey bee) XP_001951736.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008304-PA Bombyx mori (silk worm) ENSBTAP00000001839 Bos taurus (bovine) CN29052 Caenorhabditis brenneri (small nematode) CBP27393 Caenorhabditis briggsae (nematode) CE05274 Caenorhabditis elegans (worm) ENSCAFP00000008032 Canis familiaris (dog) ENSCAFP00000023241 Canis familiaris (dog) ENSCINP00000016460 Ciona intestinalis (sea squirt) cn10239 Cryptococcus neoformans (yeast-like fungus) CPIJ007754 Culex pipens (mosquito) ENSCPOP00000010642 Cavia porcellus (guinea pig) RP17681 Caenorhabditis remanei (nematode) ENSCSAVP00000013099 Ciona savignyi (sedentary tunicate) DDB0191195 Dictyostelium discoideum (amoeba) 299642 Daphnia pulex (daphnia) ENSDARP00000087032 Danio rerio (zebra fish) ENSECAP00000017503 Equus caballus (horse) XP_655136 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000026547 Gymnopilus aculeatus (mushroom) ENSGALP00000036651 Gallus gallus (chicken) 119785 Hypsipyla robusta (cedar shoot borer) ENSP00000263826 Homo sapiens (human) ISCW018284-PA Ixodes scapularis (deer tick) 181288 Lottia gigantea (owl limpet) 34933 Monocosta brevicollis (choanoflagellate) ENSMODP00000008221 Monodelphis domestica (gray opossum) ENSMMUP00000026292 Macaca mulatta (rhesus monkey) ENSMUSP00000106790 Mus musculus (house mouse) 115630 Nematostella vectensis (starlet anemone) XP_001605990.1 Nasonia vitripennis (wasp) ENSOANP00000016282 Ornithorynchus anatinus (platypus) ENSORLP00000006529 Oryzias latipes (japanese killifish) PHUM001973-PA Pediculus humanus (human body louse) ENSPPYP00000000057 Pongo pygmaeus (orangutan) ENSPTRP00000050982 Pan troglodytes (chimpanzee) ENSRNOP00000025303 Rattus norvegicus (norway rat) Smp_073930.2 Schistosoma mansoni (trematode parasite) XP_787246.2 Strongylocentrotus purpuratus (purple sea urchin) 51134 Trichoplax adhaerens (metazoa) Tc00.1047053508965.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509007.60 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007984 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021654 Takifugu rubripes (pufferfish Takifugu) 3809.m00209 Tetrahymena thermophila (ciliate protozoa) 90981.m00083 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037022 Xenopus tropicalis (frog) YALI0E06501g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/akt1-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41957 modMine - Data generated by the modENCODE project. • FBgn0010379 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10151 ISCW018284 FBgn0241490 FBgn0215271 FBgn0215269 FBgn0210484 FBgn0190581 FBgn0179148 JGI_V11_299642 FBgn0077857 FBgn0149827 FBgn0145383 FBgn0126232 FBgn0109206 FBgn0093177 CPIJ007754 BGIBMGA008304 ACYPI002231 GB15685 AGAP002161 AAEL008823 PHUM299490 GLEAN_07749
Synonyms & Secondary IDs ( 42 )
Reported As
Symbol Synonym	AKT (Edgar, 2006, Schwartz and Pirrotta, 2007, Burgering and Kops, 2002, Leopold, 2004, Abrams, 1999, Morrison et al., 2000, Spana and Perrimon, 1999, Liu and Lehmann, 2006, Hietakangas and Cohen, 2007, Hietakangas and Cohen, 2007, Bakal et al., 2008, Lee et al., 2010, Yan et al., 2009, Jones et al., 2009, Xu et al., 2008, Kohyama-Koganeya et al., 2008, Mattila et al., 2008, Wu et al., 2009, Zheng and Sehgal, 2010, Villa-Cuesta et al., 2010, Georgiev et al., 2010, Ashton-Beaucage et al., 2010, Sun et al., 2011, Resnik-Docampo and de Celis, 2011) Akt (Vereshchagina and Wilson, 2006, Shingleton, 2005, Bjorklund et al., 2006, Dong and Pan, 2004, Pan et al., 2004, Pagliarini et al., 2004, Sherr, 2004, Neufeld, 2003, Puig et al., 2003, Potter et al., 2002, Jin et al., 2001, Davies, 2002, Anselmo et al., 2002, Gao and Pan, 2001, Potter and Xu, 2001, Potter et al., 2001, Lu et al., 2001, Potter et al., 2000, Meier and Evan, 1998, Luo et al., 2006, Lavery and Stern, 2006, Dionne and Schneider, 2006, Zinke et al., 2007, Wilson et al., 2007, Dionne and Schneider, 2007, Yang et al., 2006, Takacs-Vellai, 2006, Wullschleger, 2006, Dionne et al., 2006, Gao et al., 2005, Fuss et al., 2007, Dionne, 2007, Hoshizaki and Gibbs, 2007, Libert, 2007, Ahrens et al., 2007, Fuss et al., 2006, Liu and Lehmann, 2006, Cavaliere et al., 2005, Dong et al., 2007, Berry and Baehrecke, 2007, Ikeya et al., 2009, Yu et al., 2008, Choi et al., 2008, Wang et al., 2008, Hennig et al., 2006, Lee and Chung, 2007, Lazzaro and Galac, 2006, Scanga et al., 2000, Simcox et al., 2008, Lavery et al., 2007, Martin-Pena et al., 2006, Luo et al., 2007, Buttrick et al., 2008, Tseng et al., 2007, Lee et al., 2008, Jovceva et al., 2007, Vereshchagina et al., 2008, Dutta and Baehrecke, 2008, Lee et al., 2008, Read et al., 2009, Shelly et al., 2009, Walkiewicz and Stern, 2009, Hyun et al., 2009, Ueishi et al., 2009, Schleich and Teleman, 2009, Qian and Bodmer, 2009, Branco et al., 2008, Parrish et al., 2009, Wu et al., 2009, Koike-Kumagai et al., 2009, Maynard et al., 2010, Tiefenböck et al., 2010, Puseenam et al., 2009, Sekine et al., 2010, Birse et al., 2010, Gangaraju et al., 2011, Wang et al., 2008, Funakoshi et al., 2011, Chell and Brand, 2010, Chun-Jen Lin et al., 2011, Bjedov et al., 2010) akt (Potter et al., 2001, Guo and Zhong, 2006, Parrish et al., 2009) Akt1 (Goberdhan et al., 2005, Ramel, 2007, Walker et al., 2006, Friedman and Perrimon, 2006, Dietzl et al., 2007, Zhou et al., 2008, Kaplan et al., 2008, Demontis and Perrimon, 2009, Harbison et al., 2009, Alvarez-Ponce et al., 2009, Nuzhdin et al., 2009, Tain et al., 2009, Cook et al., 2010.1.8, Pinal et al., 2006, Sims et al., 2009, Robinson et al., 2010, Fernández-Ayala et al., 2010, Aron et al., 2010, Curtis et al., 2007, Tsuda et al., 2010, Folberg-Blum et al., 2002, Terashima and Bownes, 2005, Eddison et al., 2011, Reis et al., 2010) AKT1 (Slack et al., 2010, Liévens et al., 2008) akt1 (Buttrick et al., 2008, Davidson et al., 2009, Coffman et al., 2005) Akt/PKB (Longo and Finch, 2003, Strauss, 2001, Siudeja et al., 2007) AKT/PKB (Gingras et al., 2001, Colombani et al., 2005) CG4006 (Morrison et al., 2000, Whitfield, 2000.5.15, Demontis and Perrimon, 2009, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1) dAkt (Jorgensen and Tyers, 2004, Kockel et al., 2005, Hay and Sonenberg, 2004, Cavaliere et al., 2003, Maehama et al., 2004, Pagliarini and Xu, 2003, Manning and Cantley, 2003, Hafen and Stocker, 2003, Lee et al., 2003, Kramer et al., 2003, Jacinto and Hall, 2003, Cavaliere et al., 2003, Marygold and Leevers, 2002, Stocker et al., 2002, Keyes et al., 1999, DiAngelo and Birnbaum, 2007, Guertin et al., 2006, Yang et al., 2006, Lasko and Sonenberg, 2007, Song et al., 2010, Slack et al., 2010, DiAngelo et al., 2008, Miron et al., 2003, Read et al., 2009, Diangelo et al., 2009, Cliffe et al., 2009, Kim et al., 2008, Porstmann et al., 2008) Dakt (Kohanski, 2002, Johnston and Gallant, 2002, Stocker and Hafen, 2000) D-Akt (Lavenburg et al., 2002, Scanga et al., 2000) dakt (Guo and Zhong, 2006) DAkt (Orme et al., 2006) dAKT (Dekanty et al., 2005, Delanoue et al., 2010, Kim et al., 2004) dAkt1 (Inoki and Guan, 2006, Shi et al., 2005, Chen et al., 2003, Miron et al., 2001, Rintelen et al., 2001, Bradley et al., 2001, Coelho and Leevers, 2000, Cortina-Andrada et al., 2007, Igaki et al., 2006, Igaki et al., 2006) Dakt1 (Potter et al., 2002, Jin et al., 2001, Downward and Leevers, 2001, Aigaki et al., 2002, Cho et al., 2001, Radimerski et al., 2001, Gao et al., 2000, Wetsch et al., 2000, Verdu et al., 1999, Edgar, 1999, Franke, 1993.9.9, Verdu et al., 1999, Staveley et al., 1998, Franke et al., 1994, Scanga et al., 2000, Lavenburg et al., 2003) DAkt1 (Weinkove and Leevers, 2000) DAKT1 (Leevers, 1999) dakt1 (Nunez and del Peso, 1998) dAKT1 (Moon et al., 2006) DAKT1/PKB (Claeys et al., 2002) dAKT/dPKB (Sarbassov et al., 2005) dAkt/PKB (Stocker et al., 2003, Frias et al., 2006) dPKB (Junger et al., 2003, Radimerski et al., 2002, Oldham and Hafen, 2003, Radimerski et al., 2002, Radimerski et al., 2002, Oldham et al., 2000, Liu and Lehmann, 2006, Wittwer et al., 2005, Lizcano et al., 2003) DPKB (Coffer et al., 1998) DRAC-PK (Andjelkovic et al., 1995, Andjelkovic et al., 1994) DRAC-PK66; DRAC-PK85 (Hemmnings, 1994.12.14) l(3)89Bq (Lu et al., 2001, Heitzler et al., 1996, ) l(3)04226 (Berkeley Drosophila Genome Project, 1993.6.1, Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) p-Akt (Howlett et al., 2008) pAkt (Simcox et al., 2008) PKB (Partridge, 2005, Reiling et al., 2005, Reiling and Hafen, 2004, Stambolic et al., 1999, Stocker et al., 2003, Nijhout, 2003, Stocker et al., 2004, McManus and Alessi, 2002, Jin et al., 2001, Saucedo and Edgar, 2002, Downward and Leevers, 2001, Wittwer et al., 2003, Reiling and Hafen, 2003, Towers and Sattelle, 2002, Lawlor and Alessi, 2001, Kozma and Thomas, 2002, Clancy et al., 2001, Wells, 2001, Lehner, 1999, Spana and Perrimon, 1999, Werz et al., 2009) PKB/AKT (Findlay et al., 2005, Staveley et al., 1998) PKB/Akt (Clague et al., 2004) PKB/dAKT (Ghabrial et al., 2003) RAC (Wallingford and Habas, 2005, Jones et al., 1992) RacPK
Name Synonym	Akt1 (Aron et al., 2010) dAkt kinase (Cavaliere et al., 2005) Protein kinase B (Terashima and Bownes, 2005) Related to PKA to PKC protein kinases (Andjelkovic et al., 1994) related to the A and C kinases (Jones et al., 1992)
Secondary FlyBase IDs
	FBgn0010837 FBgn0013324 FBgn0017365
References ( 284 )
Generate a list of	All references relating to this gene ( 284 )
List References by type	Research paper  ( 153 ) Supplementary material  ( 6 ) Review  ( 60 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 40 ) Letter  ( 1 ) DNA/RNA sequence record  ( 2 ) Conference report  ( 3 ) Computer file  ( 4 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 28 )
	Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Chun-Jen Lin et al., 2011, Genetics 188(3): 601--613 The Metabotropic Glutamate Receptor Activates the Lipid Kinase PI3K in Drosophila Motor Neurons Through the Calcium/Calmodulin-Dependent Protein Kinase II and the Nonreceptor Tyrosine Protein Kinase DFak. [FBrf0214227] Eddison et al., 2011, Neuron 70(5): 979--990 arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. [FBrf0213908] Funakoshi et al., 2011, Biochem. Biophys. Res. Commun. 405(4): 667--672 A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. [FBrf0213115] Gangaraju et al., 2011, Nat. Genet. 43(2): 153--158 Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. [FBrf0212873] Gibbens et al., 2011, Development 138(13): 2693--2703 Neuroendocrine regulation of Drosophila metamorphosis requires TGF{beta}/Activin signaling. [FBrf0213899] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Sun et al., 2011, PLoS ONE 6(4): e18215 Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. [FBrf0213560] Willecke et al., 2011, Oncogene 30(39): 4067--4074 Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. [FBrf0216281] Aron et al., 2010, PLoS Biol. 8(4): e1000349 Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons. [FBrf0210541] Ashton-Beaucage et al., 2010, Cell 143(2): 251--262 The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. [FBrf0212064] Birse et al., 2010, Cell Metab. 12(5): 533--544 High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. [FBrf0212220] Bjedov et al., 2010, Cell Metab. 11(1): 35--46 Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. [FBrf0214947] Chell and Brand, 2010, Cell 143(7): 1161--1173 Nutrition-responsive glia control exit of neural stem cells from quiescence. [FBrf0212551] Delanoue et al., 2010, Dev. Cell 18(6): 1012--1021 The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. [FBrf0211284] Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Georgiev et al., 2010, Cell Metab. 12(4): 386--397 TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development. [FBrf0211938] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Maynard et al., 2010, Dev. Biol. 339(2): 295--306 Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. [FBrf0210107] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Sekine et al., 2010, J. Biol. Chem. 285(49): 38684--38691 Blocking O-Linked GlcNAc Cycling in Drosophila Insulin-producing Cells Perturbs Glucose-Insulin Homeostasis. [FBrf0212389] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Song et al., 2010, Cell Metab. 11(5): 427--437 SH2B regulation of growth, metabolism, and longevity in both insects and mammals. [FBrf0210745] Tiefenböck et al., 2010, EMBO J. 29(1): 171--183 The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. [FBrf0209639] Tsuda et al., 2010, FEBS Lett. 584(22): 4689--4694 POSH promotes cell survival in Drosophila and in human RASF cells. [FBrf0212255] Villa-Cuesta et al., 2010, PLoS ONE 5(7): e11521 A Role for Drosophila dFoxO and dFoxO 5'UTR Internal Ribosomal Entry Sites during Fasting. [FBrf0211270] Zheng and Sehgal, 2010, Curr. Biol. 20(13): 1203--1208 AKT and TOR Signaling Set the Pace of the Circadian Pacemaker. [FBrf0211221] Show all research papers ...
Recent reviews ( 1 )
	Teleman, 2010, Biochem. J. 425(1): 13--26 Molecular mechanisms of metabolic regulation by insulin in Drosophila. [FBrf0209514] Show all reviews ...