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Gene Dmel\AP-1-2β

General Information
Symbol	Dmel\AP-1-2β	Species	D. melanogaster
Name	Adaptor Protein complex 1/2, β subunit	Annotation symbol	CG12532
Feature type	protein_coding_gene	FlyBase ID	FBgn0010380
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	bap, AP-2β, BAD1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	18E4-18E5	Sequence location	X:19,625,037..19,628,614 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adaptor Protein complex 1/2, β subunit is referred to in FlyBase by the symbol Dmel\AP-1-2β (CG12532, FBgn0010380). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: protein transporter activity. There is experimental evidence that it is involved in the biological process: compound eye development. 5 alleles are reported. The phenotype of these alleles is annotated with: eye. It has one annotated transcript and one annotated polypeptide. Protein features are: AP complex subunit beta; AP-1, 2,4 complex subunit beta; Armadillo-like helical; Armadillo-type fold; Beta-adaptin appendage, C-terminal subdomain; Beta2-adaptin/TBP, C-terminal domain; Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain; Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain; Clathrin/coatomer adaptor, adaptin-like, N-terminal; Coatomer/calthrin adaptor appendage, C-terminal subdomain; Coatomer/clathrin adaptor appendage, Ig-like subdomain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult fat body, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638673_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Bap. Gene sequence location is X:19625037..19628614.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18E4-18E5   Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
Experimentally Determined Cytological Location
Cytogenetic map Notes References 18E1-18E2     (Pearse, 1993.11.2) 18E-18F   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AP-1-2β for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47 DGC clone appears problematic: incomplete CDS (SD04106)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AP-1-2β-RA FBtr0074789  NM_078691   3228   921
Additional Transcript Data & Comments
Reported size (kB)	3.217 (longest cDNA) (Camidge and Pearse, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AP-1-2β-PA   FBpp0074558   101.2   921   4.73     NP_523415   AAF49013
Additional Polypeptide Data & Comments
Reported size (kDa)	921 (aa); 100 (kD observed) (Camidge and Pearse, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Clathrin/coatomer adaptor, adaptin-like, N-terminal (IPR002553) Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (IPR008152) Coatomer/calthrin adaptor appendage, C-terminal subdomain (IPR009028) Armadillo-like helical (IPR011989) Beta2-adaptin/TBP, C-terminal domain (IPR012295) Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain (IPR013037) Coatomer/clathrin adaptor appendage, Ig-like subdomain (IPR013041) Beta-adaptin appendage, C-terminal subdomain (IPR015151) Armadillo-type fold (IPR016024) AP-1, 2,4 complex subunit beta (IPR016342) AP complex subunit beta (IPR026739)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142180   AA201182   AA392346   AA816469   AA820488   AA941421   AA942336   AA949541   AE014298 AAF49013   AI063307   AI063523   AI107334   AI107565   AI135091   AI135562   AI239245   AI295119   AI386601   AI387259   AI387697   AI388073   AI388197   AI388686   AI403306   AI404669   AI455689   AI456969   AI512712   AI519460   AI530805   AI532560   AI533827   AI534415   AI534518   AI534994   AW944345   AY052092 AAK93516   BF486291   BF486886   BF494401   BG635233   BG639491   BG640184   BI164240   BI164340   BI164423   BI168170   BI170153   BI170960   BI213307   BI213509   BI215361   BI236447   BI237021   BI240237   BI240330   BI357920   BI358384   BI361690   BI365693   BI483538   BI566870   BI568424   BI574981   BI575513   BI578519   BI579703   BI580646   BI582656   BI587006   BI588143   BI589342   BI616242   BI626712   BI634972   BP544948   BP544949   BT016054 AAV36939   BX070545   CK132016   CK604718   CK657613   CK659076   CK659980   CO279518   CO296871   CO333070   EC051736   EC067906   EC212014   EC227113   EC232780   EC247714   EV580753   EV595386   GH740612   GH741334   GH744843   GH762880   GH763037   GH763225   GH763518   GH764452   GH766338   GH766694   GH767141   GH767164   X75910 CAA53509
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24253 Q960F2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Immunolocalization studies with Drosophila Kc cells reveal a punctate pattern of bap protein distribution, possibly in coated pits. (Camidge and Pearse, 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
AP-type membrane coat adaptor complex inferred from direct assay (Camidge and Pearse, 1994) clathrin-coated vesicle inferred from direct assay (Hirst et al., 2009) coated pit inferred from direct assay (Camidge and Pearse, 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult fat body, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    867.375 Larval Midgut    729.7 Larval Hindgut    953.5 Larval Malpighian Tubules    953.7 Larval Fat Body    631.4 Larval Salivary Gland    1298.6 Larval Trachea    650.1 Larval Carcass    581.8 Adult Head    555.1 Adult Eye    518.775 Adult Brain    923.2 Adult Thoracic-Abdominal Ganglion    1168.5 Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut    539.9 Adult Malpighian Tubules    532.5 Adult Fat Body    425.8 Adult Salivary Gland    976.7 Adult Heart    810.125 Adult VirginFemale Spermatheca    683.5 Adult InseminatedFemale Spermatheca    820.7 Adult Ovary    604.5 Adult Testis    160.7 Adult Male Accessory Gland    1090.6 Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (867.375) Larval Midgut  (729.7) Larval Hindgut  (953.5) Larval Malpighian Tubules  (953.7) Larval Fat Body  (631.4) Larval Salivary Gland  (1298.6) Larval Trachea  (650.1) Larval Carcass  (581.8) Adult Head  (555.1) Adult Eye  518.775 Adult Brain  (923.2) Adult Thoracic-Abdominal Ganglion  (1168.5) Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut  (539.9) Adult Malpighian Tubules  532.5 Adult Fat Body    425.8 Adult Salivary Gland  (976.7) Adult Heart  (810.125) Adult VirginFemale Spermatheca  (683.5) Adult InseminatedFemale Spermatheca  (820.7) Adult Ovary  (604.5) Adult Testis    160.7 Adult Male Accessory Gland  (1090.6) Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    867.375 Larval Midgut    729.7 Larval Hindgut    953.5 Larval Malpighian Tubules    953.7 Larval Fat Body    631.4 Larval Salivary Gland  (1298.6) Larval Trachea    650.1 Larval Carcass    581.8 Adult Head    555.1 Adult Eye    518.775 Adult Brain    923.2 Adult Thoracic-Abdominal Ganglion  (1168.5) Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut    539.9 Adult Malpighian Tubules    532.5 Adult Fat Body    425.8 Adult Salivary Gland    976.7 Adult Heart    810.125 Adult VirginFemale Spermatheca    683.5 Adult InseminatedFemale Spermatheca    820.7 Adult Ovary    604.5 Adult Testis    160.7 Adult Male Accessory Gland  (1090.6) Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    867.375 Larval Midgut    729.7 Larval Hindgut    953.5 Larval Malpighian Tubules    953.7 Larval Fat Body    631.4 Larval Salivary Gland    1298.6 Larval Trachea    650.1 Larval Carcass    581.8 Adult Head    555.1 Adult Eye    518.775 Adult Brain    923.2 Adult Thoracic-Abdominal Ganglion    1168.5 Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut    539.9 Adult Malpighian Tubules    532.5 Adult Fat Body    425.8 Adult Salivary Gland    976.7 Adult Heart    810.125 Adult VirginFemale Spermatheca    683.5 Adult InseminatedFemale Spermatheca    820.7 Adult Ovary    604.5 Adult Testis    160.7 Adult Male Accessory Gland    1090.6 Adult Carcass    436 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    867.375 Larval Midgut    729.7 Larval Hindgut    953.5 Larval Malpighian Tubules    953.7 Larval Fat Body    631.4 Larval Salivary Gland    1298.6 Larval Trachea    650.1 Larval Carcass    581.8 Adult Head    555.1 Adult Eye    518.775 Adult Brain    923.2 Adult Thoracic-Abdominal Ganglion    1168.5 Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut    539.9 Adult Malpighian Tubules    532.5 Adult Fat Body    425.8 Adult Salivary Gland    976.7 Adult Heart    810.125 Adult VirginFemale Spermatheca    683.5 Adult InseminatedFemale Spermatheca    820.7 Adult Ovary    604.5 Adult Testis    160.7 Adult Male Accessory Gland    1090.6 Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (867.375) Larval Midgut  729.7 Larval Hindgut  (953.5) Larval Malpighian Tubules  (953.7) Larval Fat Body  631.4 Larval Salivary Gland  (1298.6) Larval Trachea  650.1 Larval Carcass  581.8 Adult Head  555.1 Adult Eye  518.775 Adult Brain  (923.2) Adult Thoracic-Abdominal Ganglion  (1168.5) Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut  539.9 Adult Malpighian Tubules  532.5 Adult Fat Body    425.8 Adult Salivary Gland  (976.7) Adult Heart  810.125 Adult VirginFemale Spermatheca  683.5 Adult InseminatedFemale Spermatheca  (820.7) Adult Ovary  604.5 Adult Testis    160.7 Adult Male Accessory Gland  (1090.6) Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    867.375 Larval Midgut    729.7 Larval Hindgut    953.5 Larval Malpighian Tubules    953.7 Larval Fat Body    631.4 Larval Salivary Gland  1298.6 Larval Trachea    650.1 Larval Carcass    581.8 Adult Head    555.1 Adult Eye    518.775 Adult Brain    923.2 Adult Thoracic-Abdominal Ganglion  1168.5 Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut    539.9 Adult Malpighian Tubules    532.5 Adult Fat Body    425.8 Adult Salivary Gland    976.7 Adult Heart    810.125 Adult VirginFemale Spermatheca    683.5 Adult InseminatedFemale Spermatheca    820.7 Adult Ovary    604.5 Adult Testis    160.7 Adult Male Accessory Gland  1090.6 Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    867.375 Larval Midgut    729.7 Larval Hindgut    953.5 Larval Malpighian Tubules    953.7 Larval Fat Body    631.4 Larval Salivary Gland    1298.6 Larval Trachea    650.1 Larval Carcass    581.8 Adult Head    555.1 Adult Eye    518.775 Adult Brain    923.2 Adult Thoracic-Abdominal Ganglion    1168.5 Adult Crop    463.3 Adult Midgut    462.1 Adult Hindgut    539.9 Adult Malpighian Tubules    532.5 Adult Fat Body    425.8 Adult Salivary Gland    976.7 Adult Heart    810.125 Adult VirginFemale Spermatheca    683.5 Adult InseminatedFemale Spermatheca    820.7 Adult Ovary    604.5 Adult Testis    160.7 Adult Male Accessory Gland    1090.6 Adult Carcass    436 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    555.1   NA  Eye    518.775   NA  Brain    923.2   867.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1168.5   NA  Crop    463.3   729.7  Midgut    462.1   953.5  Hindgut    539.9   953.7  Malpighian Tubules    532.5   631.4  Fat Body    425.8   1298.6  Salivary Gland    976.7   NA  Heart    810.125   650.1  Trachea    NA   NA  VirginFemale Spermatheca    683.5   NA  InseminatedFemale Spermatheca    820.7   NA  Ovary    604.5   NA  Testis    160.7   NA  Male Accessory Gland    1090.6   581.8  Carcass    436 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    50 central nervous system, pupae P8    51 head, virgin 1-day female    29 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male    40 head, mated 4-day male    37 head, mated 20-day male    40 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult    26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female    47 ovary, mated 4-day female    44 testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3  (50) central nervous system, pupae P8  (51) head, virgin 1-day female  (29) head, virgin 4-day female  26 head, virgin 20-day female  26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male  (40) head, mated 4-day male  (37) head, mated 20-day male  (40) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (34) digestive system, larvae L3 wandering  (36) digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult  26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering  (30) carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female  (47) ovary, mated 4-day female  (44) testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    50 central nervous system, pupae P8    51 head, virgin 1-day female    29 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male    40 head, mated 4-day male    37 head, mated 20-day male    40 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult    26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female    47 ovary, mated 4-day female    44 testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    50 central nervous system, pupae P8    51 head, virgin 1-day female    29 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male    40 head, mated 4-day male    37 head, mated 20-day male    40 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult    26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female    47 ovary, mated 4-day female    44 testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    50 central nervous system, pupae P8    51 head, virgin 1-day female    29 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male    40 head, mated 4-day male    37 head, mated 20-day male    40 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult    26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female    47 ovary, mated 4-day female    44 testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3  (50) central nervous system, pupae P8  (51) head, virgin 1-day female  29 head, virgin 4-day female  26 head, virgin 20-day female  26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male  (40) head, mated 4-day male  (37) head, mated 20-day male  (40) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (34) digestive system, larvae L3 wandering  (36) digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult  26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering  30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female  (47) ovary, mated 4-day female  (44) testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    50 central nervous system, pupae P8    51 head, virgin 1-day female    29 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male    40 head, mated 4-day male    37 head, mated 20-day male    40 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult    26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female    47 ovary, mated 4-day female    44 testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    50 central nervous system, pupae P8    51 head, virgin 1-day female    29 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    21 head, mated 1-day male    40 head, mated 4-day male    37 head, mated 20-day male    40 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    18 digestive system, 4-day adult    16 digestive system, 20-day adult    26 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    17 carcass, 4-day adult    18 carcass, 20-day adult    17 ovary, virgin 4-day female    47 ovary, mated 4-day female    44 testis, mated 4-day male    16 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    102 embryo 02-04hr    86 embryo 04-06hr    67 embryo 06-08hr    80 embryo 08-10hr    77 embryo 10-12hr    84 embryo 12-14hr    56 embryo 14-16hr    77 embryo 16-18hr    56 embryo 18-20hr    51 embryo 20-22hr    42 embryo 22-24hr    39 larva L1    53 larva L2    46 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    54 white prepupae new    62 white prepupae 12hr    52 white prepupae 24hr    57 pupae 2d postWPP    54 pupae 3d postWPP    39 pupae 4d postWPP    36 adult male 01day    39 adult male 05day    39 adult male 30day    41 adult female 01day    67 adult female 05day    66 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (102) embryo 02-04hr  (86) embryo 04-06hr  (67) embryo 06-08hr  (80) embryo 08-10hr  (77) embryo 10-12hr  (84) embryo 12-14hr  (56) embryo 14-16hr  (77) embryo 16-18hr  (56) embryo 18-20hr  (51) embryo 20-22hr  (42) embryo 22-24hr  (39) larva L1  (53) larva L2  (46) larva L3 12hr old  (34) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (54) white prepupae new  (62) white prepupae 12hr  (52) white prepupae 24hr  (57) pupae 2d postWPP  (54) pupae 3d postWPP  (39) pupae 4d postWPP  (36) adult male 01day  (39) adult male 05day  (39) adult male 30day  (41) adult female 01day  (67) adult female 05day  (66) adult female 30day  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  102 embryo 02-04hr    86 embryo 04-06hr    67 embryo 06-08hr    80 embryo 08-10hr    77 embryo 10-12hr    84 embryo 12-14hr    56 embryo 14-16hr    77 embryo 16-18hr    56 embryo 18-20hr    51 embryo 20-22hr    42 embryo 22-24hr    39 larva L1    53 larva L2    46 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    54 white prepupae new    62 white prepupae 12hr    52 white prepupae 24hr    57 pupae 2d postWPP    54 pupae 3d postWPP    39 pupae 4d postWPP    36 adult male 01day    39 adult male 05day    39 adult male 30day    41 adult female 01day    67 adult female 05day    66 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    102 embryo 02-04hr    86 embryo 04-06hr    67 embryo 06-08hr    80 embryo 08-10hr    77 embryo 10-12hr    84 embryo 12-14hr    56 embryo 14-16hr    77 embryo 16-18hr    56 embryo 18-20hr    51 embryo 20-22hr    42 embryo 22-24hr    39 larva L1    53 larva L2    46 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    54 white prepupae new    62 white prepupae 12hr    52 white prepupae 24hr    57 pupae 2d postWPP    54 pupae 3d postWPP    39 pupae 4d postWPP    36 adult male 01day    39 adult male 05day    39 adult male 30day    41 adult female 01day    67 adult female 05day    66 adult female 30day    69 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    102 embryo 02-04hr    86 embryo 04-06hr    67 embryo 06-08hr    80 embryo 08-10hr    77 embryo 10-12hr    84 embryo 12-14hr    56 embryo 14-16hr    77 embryo 16-18hr    56 embryo 18-20hr    51 embryo 20-22hr    42 embryo 22-24hr    39 larva L1    53 larva L2    46 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    54 white prepupae new    62 white prepupae 12hr    52 white prepupae 24hr    57 pupae 2d postWPP    54 pupae 3d postWPP    39 pupae 4d postWPP    36 adult male 01day    39 adult male 05day    39 adult male 30day    41 adult female 01day    67 adult female 05day    66 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (102) embryo 02-04hr  (86) embryo 04-06hr  (67) embryo 06-08hr  (80) embryo 08-10hr  (77) embryo 10-12hr  (84) embryo 12-14hr  (56) embryo 14-16hr  (77) embryo 16-18hr  (56) embryo 18-20hr  (51) embryo 20-22hr  (42) embryo 22-24hr  (39) larva L1  (53) larva L2  (46) larva L3 12hr old  (34) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (54) white prepupae new  (62) white prepupae 12hr  (52) white prepupae 24hr  (57) pupae 2d postWPP  (54) pupae 3d postWPP  (39) pupae 4d postWPP  (36) adult male 01day  (39) adult male 05day  (39) adult male 30day  (41) adult female 01day  (67) adult female 05day  (66) adult female 30day  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  102 embryo 02-04hr    86 embryo 04-06hr    67 embryo 06-08hr    80 embryo 08-10hr    77 embryo 10-12hr    84 embryo 12-14hr    56 embryo 14-16hr    77 embryo 16-18hr    56 embryo 18-20hr    51 embryo 20-22hr    42 embryo 22-24hr    39 larva L1    53 larva L2    46 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    54 white prepupae new    62 white prepupae 12hr    52 white prepupae 24hr    57 pupae 2d postWPP    54 pupae 3d postWPP    39 pupae 4d postWPP    36 adult male 01day    39 adult male 05day    39 adult male 30day    41 adult female 01day    67 adult female 05day    66 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    102 embryo 02-04hr    86 embryo 04-06hr    67 embryo 06-08hr    80 embryo 08-10hr    77 embryo 10-12hr    84 embryo 12-14hr    56 embryo 14-16hr    77 embryo 16-18hr    56 embryo 18-20hr    51 embryo 20-22hr    42 embryo 22-24hr    39 larva L1    53 larva L2    46 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    54 white prepupae new    62 white prepupae 12hr    52 white prepupae 24hr    57 pupae 2d postWPP    54 pupae 3d postWPP    39 pupae 4d postWPP    36 adult male 01day    39 adult male 05day    39 adult male 30day    41 adult female 01day    67 adult female 05day    66 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    69 embryonic 1182-4H    85 embryonic GM2    53 embryonic Kc167    34 embryonic S1    93 embryonic S3    56 leg disc CME L1    76 wing disc CME-W2    40 wing disc ML-DmD8    48 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    86 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    79 eye-antennal disc ML-DmD11    80 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    46 ovary fGS/OSS    84 ovary OSC    55 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (102) Schneider line 2 Sg4  (69) embryonic 1182-4H  (85) embryonic GM2  (53) embryonic Kc167  (34) embryonic S1  (93) embryonic S3  (56) leg disc CME L1  (76) wing disc CME-W2  (40) wing disc ML-DmD8  (48) wing disc ML-DmD9  (92) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (86) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (79) eye-antennal disc ML-DmD11  (80) antennal disc ML-DmD20-c5  (65) mixed discs ML-DmD4-c1  (64) CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (46) ovary fGS/OSS  (84) ovary OSC  (55) ovary OSS  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  102 Schneider line 2 Sg4    69 embryonic 1182-4H    85 embryonic GM2    53 embryonic Kc167    34 embryonic S1    93 embryonic S3    56 leg disc CME L1    76 wing disc CME-W2    40 wing disc ML-DmD8    48 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    86 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    79 eye-antennal disc ML-DmD11    80 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    46 ovary fGS/OSS    84 ovary OSC    55 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    69 embryonic 1182-4H    85 embryonic GM2    53 embryonic Kc167    34 embryonic S1    93 embryonic S3    56 leg disc CME L1    76 wing disc CME-W2    40 wing disc ML-DmD8    48 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    86 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    79 eye-antennal disc ML-DmD11    80 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    46 ovary fGS/OSS    84 ovary OSC    55 ovary OSS    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    69 embryonic 1182-4H    85 embryonic GM2    53 embryonic Kc167    34 embryonic S1    93 embryonic S3    56 leg disc CME L1    76 wing disc CME-W2    40 wing disc ML-DmD8    48 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    86 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    79 eye-antennal disc ML-DmD11    80 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    46 ovary fGS/OSS    84 ovary OSC    55 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (102) Schneider line 2 Sg4  (69) embryonic 1182-4H  (85) embryonic GM2  (53) embryonic Kc167  (34) embryonic S1  (93) embryonic S3  (56) leg disc CME L1  (76) wing disc CME-W2  (40) wing disc ML-DmD8  (48) wing disc ML-DmD9  (92) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (86) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (79) eye-antennal disc ML-DmD11  (80) antennal disc ML-DmD20-c5  (65) mixed discs ML-DmD4-c1  (64) CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (46) ovary fGS/OSS  (84) ovary OSC  (55) ovary OSS  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  102 Schneider line 2 Sg4    69 embryonic 1182-4H    85 embryonic GM2    53 embryonic Kc167    34 embryonic S1    93 embryonic S3    56 leg disc CME L1    76 wing disc CME-W2    40 wing disc ML-DmD8    48 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    86 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    79 eye-antennal disc ML-DmD11    80 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    46 ovary fGS/OSS    84 ovary OSC    55 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    69 embryonic 1182-4H    85 embryonic GM2    53 embryonic Kc167    34 embryonic S1    93 embryonic S3    56 leg disc CME L1    76 wing disc CME-W2    40 wing disc ML-DmD8    48 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    86 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    79 eye-antennal disc ML-DmD11    80 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    64 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    46 ovary fGS/OSS    84 ovary OSC    55 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (27) heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult  (39) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  27 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult  (39) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010380 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12532-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act.PU AP-1-2βNIG.12532R lethal, with Scer\GAL4ey.PU AP-1-2βNIG.12532R lethal | pupal stage, with Scer\GAL4pnr-MD237 AP-1-2βGD1204 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PU AP-1-2βNIG.12532R
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of AP-1-2β Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AP-1-2β Class Mutagen Stocks Known lesion AP-1-2βGD1204 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AP-1-2βHM04014 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AP-1-2βJF02963 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AP-1-2βdsRNA.cRa in vitro construct - RNAi 0 Yes AP-1-2βNIG.12532R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6253 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Kametaka et al., 2012)
Cellular Component
CV term Evidence References
AP-type membrane coat adaptor complex inferred from direct assay (Camidge and Pearse, 1994) clathrin-coated vesicle inferred from direct assay (Hirst et al., 2009) coated pit inferred from direct assay (Camidge and Pearse, 1994)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
protein transporter activity inferred by curator from GO:0030119 (Camidge and Pearse, 1994) inferred from electronic annotation with InterPro:IPR016342 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
intracellular protein transport inferred from electronic annotation with InterPro:IPR002553, InterPro:IPR008152, InterPro:IPR009028, InterPro:IPR013037, InterPro:IPR015151 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle coating traceable author statement (Stimson and Ramaswami, 1999) vesicle coating traceable author statement (Stimson and Ramaswami, 1999) vesicle-mediated transport inferred from electronic annotation with InterPro:IPR002553, InterPro:IPR008152, InterPro:IPR009028, InterPro:IPR013037, InterPro:IPR015151 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
AP-1 adaptor complex inferred from sequence or structural similarity with human AP1B1 (FlyBase, 1992-) non-traceable author statement (Pearse, 1993.11.2) coated vesicle traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle traceable author statement (Stimson and Ramaswami, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
AP-1-2β - AP-2α experimental knowledge based (Guruharsha et al., 2011) AP-1-2β - AP-2μ experimental knowledge based (Guruharsha et al., 2011) AP-1-2β - AP-2σ experimental knowledge based (Guruharsha et al., 2011) AP-1-2β - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG14427 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG15471 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG3106 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG4338 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG4813 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG6227 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG6652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - CG7379 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Hexim experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) AP-1-2β - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Mbs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Mcm3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Nak experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) AP-1-2β - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Reps experimental knowledge based (Guruharsha et al., 2011) AP-1-2β - Rlip experimental knowledge based (Guruharsha et al., 2011) AP-1-2β - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Syx6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - dco experimental knowledge based (Guruharsha et al., 2011) AP-1-2β - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - thoc7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1-2β - vri anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AP-1-2β allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59282 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010380 DroID - A comprehensive database of gene and protein interactions. • FBgn0010380 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32987
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZGPXQ Dipteran inclusive ortholog search EOG6V9TZQ Insect inclusive ortholog search EOG6N5TRR Arthropod inclusive ortholog search EOG6Q2BWG Metazoa inclusive ortholog search EOG60CW8Q
Orthologs in Drosophila Species (EOG6ZGPXQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\AP-1-2β     Drosophila sechellia   Dsec\GM22987     Drosophila sechellia   Dsec\GM22988     Drosophila erecta   Dere\GG19251 Y   Drosophila yakuba   Dyak\GE15870 Y   Drosophila ananassae   Dana\GF20213 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11682 Y   Drosophila persimilis   Dper\GL15014 Y   Drosophila willistoni   Dwil\GK17345 Y   Drosophila virilis   Dvir\GJ15746 Y   Drosophila mojavensis   Dmoj\GI16098 Y   Drosophila grimshawi   Dgri\GH17690 Y
Orthologs in non-Drosophila Dipterans (EOG6V9TZQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011650   Anopheles gambiae Malaria mosquito  Agam\AGAP001267   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001176
Orthologs in non-Dipteran Insects (EOG6N5TRR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50854   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004375   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10937   Atta cephalotes Leafcutter ant  Acep\ACEP20119   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17024   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15749   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15750   Linepithema humile Argentine ant  Lhum\LH13961   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26037   Solenopsis invicta Red fire ant  Sinv\SINV11282   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008606   Bombyx mori Silkmoth  Bmor\BGIBMGA012922   Pediculus humanus Human body louse  Phum\PHUM255010   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15061
Orthologs in non-Insect Arthropods (EOG6Q2BWG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_337718   Daphnia pulex Water flea  Dpux\JGI_V11_324067   Ixodes scapularis Deer tick  Isca\ISCW011108
Orthologs in non-Arthropod Metazoa (EOG60CW8Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\apb-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011577gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013675gn   Danio rerio Zebrafish  Drer\ap2b1   Danio rerio Zebrafish  Drer\ap1b1   Xenopus tropicalis Western clawed frog  Xtro\ap1b1   Xenopus tropicalis Western clawed frog  Xtro\ap2b1   Gallus gallus Domestic chicken  Ggal\AP1B1   Gallus gallus Domestic chicken  Ggal\AP2B1   Mus musculus House mouse  Mmus\Ap1b1   Mus musculus House mouse  Mmus\Ap2b1   Rattus norvegicus Norway rat  Rnor\Ap1b1   Rattus norvegicus Norway rat  Rnor\Ap2b1   Homo sapiens Human  Hsap\AP1B1   Homo sapiens Human  Hsap\AP2B1
Human Orthologs (2)
Gene OMIM HGNC Hsap\AP1B1     Hsap\AP2B1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17460 Drosophila erecta Dere\GG19251 Drosophila yakuba Dyak\GE15870 Drosophila ananassae Dana\GF20213 Drosophila pseudoobscura pseudoobscura Dpse\GA11682 Drosophila persimilis Dper\GL15014 Drosophila willistoni Dwil\GK17345 Drosophila virilis Dvir\GJ15746 Drosophila mojavensis Dmoj\GI16098 Drosophila grimshawi Dgri\GH17690
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28328 y1 v1; P{TRiP.JF02963}attP2 31707 y1 v1; P{TRiP.HM04014}attP2
VDRC	v7720 w1118; P{GD1204}v7720/TM3 v7721 w1118; P{GD1204}v7721/TM3
Genomic Clones ( 2 )
	BACR33M08 BACR48P17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 102 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP17054 SD04106
Other clones	DPiM_LP17054
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02878 AT20552 AT21431 AT31751 GH03043 GH03387 GH04140 GH05311 GH12721 GH13367 GH16735 GH17739 GH18291 GH18829 GH19016 GH19661 GH22718 GH24463 HL03706 LD01870 LD04106 LD11191 LD24238 LD25553 LD26481 LD28376 LD35332 LD37153 LD39066 LD44675 LP08657 LP13177 LP16543 LP18164 LP24054 RE03871 RE04002 RE04091 RE08741 RE11520 RE12596 RE18681 RE18925 RE21742 RE32505 RE33165 RE36937 RE37154 RE44548 RE45128 RE46020 RE46416 RE66449 RE72395 RE73774 RE74863 RH20938 RH27255 RH27537 RH29230 RH31209 RH31763 RH36645 RH39868 RH39958 RH46139 RH67734 SD01315 SD05792 SD07226 SD07405 SD11148 UT01402
Other clones	21342 64244 82042 165583 280972 CK00332 Dmel_dig_005075_0707_1944 Dmel_neb_013396_0640_2536 EC051736 EK134947 EK215331 EK305619 FGC028F09 RP001014085 RP001018285 RP001020883 RP001021988 RP001022713 RP001033756 RP001034084 RP001034267 RP001037041 RP001045070 RP001049646 RP001053504 SD01528
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010380 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32987
Antibody Information
	polyclonal (Camidge and Pearse, 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: AP-1-2β Bap (Bonifacino et al., 2012.12.21)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001) Isolated from a Drosophila embryonic cDNA library, using a fragment encoding bases 976 to 1938 of human β-adaptin as a probe. (Camidge and Pearse, 1994) A Bap cDNA has been cloned and sequenced. (Camidge and Pearse, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078691 RefSeq (Proteins) • NP_523415 DDBJ / EMBL / GenBank • AAF49013 AAK93516 AAV36939 AI532560 AW944345 AY052092 BT016054 CAA53509 X75910 Entrez Gene - A searchable database of RefSeq genes. • 32987 UniProtKB/TrEMBL • Q960F2 Q24253
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Clathrin/coatomer adaptor, adaptin-like, N-terminal (IPR002553) Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (IPR008152) Coatomer/calthrin adaptor appendage, C-terminal subdomain (IPR009028) Armadillo-like helical (IPR011989) Beta2-adaptin/TBP, C-terminal domain (IPR012295) Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain (IPR013037) Coatomer/clathrin adaptor appendage, Ig-like subdomain (IPR013041) Beta-adaptin appendage, C-terminal subdomain (IPR015151) Armadillo-type fold (IPR016024) AP-1, 2,4 complex subunit beta (IPR016342) AP complex subunit beta (IPR026739)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59282 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010380 DroID - A comprehensive database of gene and protein interactions. • FBgn0010380 DRSC - Results from RNAi screens. • FBgn0010380 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010380 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12532-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010380 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32987 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32987 modMine - Data generated by the modENCODE project. • FBgn0010380
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	AP-1-2β   AP-1/2β (Bonifacino et al., 2012.12.21) AP-1β1 (Hirst et al., 2009) AP1β1 (Kametaka et al., 2012) AP-2β (Lloyd et al., 2000, Orem et al., 2006) AP2β2 (Kametaka et al., 2012) apl1 (Neumann et al., 2010) apl2 (Neumann et al., 2010) AP-β1 (Ramet et al., 2002) BAD1 (Pearse, 1993.11.2, Camidge and Pearse, 1994) bap (Bellen, 2000.12.25) Bap (Yang et al., 2011) BAP (Kametaka et al., 2012) CG12532 (Ramet et al., 2002, Boehm, 2001, Verstreken and Bellen, 2000.9.4, Legube et al., 2006, Perkins et al., 2009, Ni et al., 2008, Cammarato et al., 2011, Benhra et al., 2011) cg12532 (Boehm and Bonifacino, 2002) Β-adaptin (Benhra et al., 2011) β1/2 (Boehm and Bonifacino, 2001)
Name Synonym	Adaptor Protein complex 1/2, β subunit (Bonifacino et al., 2012.12.21, ) Beta Adaptin (Cammarato et al., 2011) Beta Adaptin Drosophila 1 (Camidge and Pearse, 1994) Β Adaptin   β-adaptin (Lewin and Mellman, 1998, Newman et al., 1995, Yang et al., 2011)
Secondary FlyBase IDs
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 11 ) Review  ( 6 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 3 )
	Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648 AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589] Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Yang et al., 2011, Neuron 72(2): 285--299 Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. [FBrf0216477] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...