FlyBase Gene Report: Dmel\AP-1-2β

General Information

Symbol

Dmel\AP-1-2β

Species

D. melanogaster

Name

Adaptor Protein complex 1/2, β subunit

Annotation Symbol

CG12532

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010380

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Adaptor Protein complex 1/2, β subunit (AP-1-2β) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Bap, β-adaptin, AP-2β, BAD1, AP-1-2-beta

Key Links

Genomic Location

Cytogenetic map

18E4-18E5

Sequence location

X:19,731,004..19,734,581 [+]

Recombination map

1-64

RefSeq locus

NC_004354 REGION:19731004..19734581

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables clathrin adaptor activity

inferred by curator from GO:0030119

(Camidge and Pearse, 1994)

enables clathrin binding

inferred from electronic annotation with InterPro:IPR016342

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in compound eye development

inferred from mutant phenotype

(Kametaka et al., 2012)

involved_in positive regulation of autophagy

inferred from mutant phenotype

(Fang et al., 2016)

involved_in viral entry into host cell

inferred from high throughput mutant phenotype

(Hodgson et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR002553, InterPro:IPR008152, InterPro:IPR009028, InterPro:IPR013037, InterPro:IPR015151

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in vesicle-mediated transport

inferred by curator from GO:0030119

(Camidge and Pearse, 1994)

inferred from biological aspect of ancestor with PANTHER:PTN000123671

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

part_of AP-type membrane coat adaptor complex

inferred from direct assay

(Camidge and Pearse, 1994)

located_in clathrin-coated pit

inferred from direct assay

(Camidge and Pearse, 1994)

located_in clathrin-coated vesicle

inferred from direct assay

(Hirst et al., 2009)

located_in plasma membrane

inferred from direct assay

(Camidge and Pearse, 1994)

located_in trans-Golgi network

inferred from direct assay

(Camidge and Pearse, 1994)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of AP-2 adaptor complex

inferred from sequence or structural similarity with SGD:S000003765

(FlyBase Curators, 2008-)

Gene Group (FlyBase)

ADAPTOR PROTEIN COMPLEX 1

ADAPTOR PROTEIN COMPLEX 2

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Adaptor Protein complex 1/2, β subunit (AP-1-2β) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

ADAPTOR PROTEIN COMPLEX 1 -: Adaptor protein (AP) complexes select cargo for inclusion into clathrin coated vesicles in the late secretory and endocytic pathways. AP-1 is specific for trafficking between the trans-Golgi network and endosomes. (Adapted from PMID:10611976 and PMID:15066634).
ADAPTOR PROTEIN COMPLEX 2 -: Adaptor protein (AP) complexes select cargo for inclusion into clathrin coated vesicles in the late secretory and endocytic pathways. AP-2 is involved in plasma membrane to endosome traffic. (Adapted from PMID:10611976 and PMID:15066634).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\AP-1-2β for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24253)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

AP-1-2β-RA

FBtr0074789

NM_078691

3228

921

Additional Transcript Data and Comments

Reported size (kB)

3.217 (longest cDNA)

(Camidge and Pearse, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

AP-1-2β-PA

FBpp0074558

101.2

921

4.73

NP_523415

AAF49013

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

921 (aa); 100 (kD observed)

(Camidge and Pearse, 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AP-1-2β using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Immunolocalization studies with Drosophila Kc cells reveal a punctate pattern of Bap protein distribution, possibly in coated pits.

(Camidge and Pearse, 1994)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of AP-type membrane coat adaptor complex

inferred from direct assay

(Camidge and Pearse, 1994)

located_in clathrin-coated pit

inferred from direct assay

(Camidge and Pearse, 1994)

located_in clathrin-coated vesicle

inferred from direct assay

(Hirst et al., 2009)

located_in plasma membrane

inferred from direct assay

(Camidge and Pearse, 1994)

located_in trans-Golgi network

inferred from direct assay

(Camidge and Pearse, 1994)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AP-1-2β in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\AP-1-2β

View exonic expression by tissue for Dmel\AP-1-2β

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010380

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32987/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010380

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010380

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010380

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12532

Flygut - An atlas of the Drosophila adult midgut

FBgn0010380

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of AP-1-2β

Transgenic constructs containing regulatory region of AP-1-2β

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6253

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PU

AP-1-2β^JF02963

lethal, with Scer\GAL4^Act.PU

AP-1-2β^NIG.12532R

lethal, with Scer\GAL4^ey.PU

AP-1-2β^NIG.12532R

lethal - all die before end of pupal stage, with Scer\GAL4^elav-C155

AP-1-2β^JF02963

lethal - all die before end of pupal stage, with Scer\GAL4^Mef2.PU

AP-1-2β^JF02963

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

AP-1-2β^GD1204

lethal - all die before end of pupal stage, with Scer\GAL4^Toll-6-D42

AP-1-2β^JF02963

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

AP-1-2β^GD1204

Other Phenotypes

Allele

abnormal locomotor behavior | larval stage, with Scer\GAL4^elav-C155

AP-1-2β^JF02963

abnormal locomotor behavior | larval stage, with Scer\GAL4^Toll-6-D42

AP-1-2β^JF02963

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

AP-1-2β^JF02963

abnormal neuroanatomy | pupal stage P5 | somatic clone

AP-1-2β^Δ1

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

AP-1-2β^GD1204

abnormal size | pupal stage P5 | somatic clone

AP-1-2β^Δ1

melanotic mass phenotype, with Scer\GAL4^{SPARC-MI00329-GAL4}

AP-1-2β^JF02963

short lived, with Scer\GAL4^Mef2.PR

AP-1-2β^GD1204

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

AP-1-2β^GD1204

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

AP-1-2β^GD1204

some die during pupal stage, with Scer\GAL4^pnr-MD237

AP-1-2β^GD1204

Phenotype manifest in

Allele

autophagosome

AP-1-2β^JF02963

dendritic tree | pupal stage P5 | somatic clone

AP-1-2β^Δ1

embryonic/larval fat body

AP-1-2β^JF02963

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

AP-1-2β^JF02963

endosome

AP-1-2β^JF02963

eye, with Scer\GAL4^GMR.PU

AP-1-2β^NIG.12532R

fat body, with Scer\GAL4^{SPARC-MI00329-GAL4}

AP-1-2β^JF02963

head, with Scer\GAL4^ey.PU

AP-1-2β^JF02963

larval dorsal multidendritic neuron ddaC | pupal stage P5 | somatic clone

AP-1-2β^Δ1

lysosome

AP-1-2β^JF02963

melanotic mass, with Scer\GAL4^{SPARC-MI00329-GAL4}

AP-1-2β^JF02963

NMJ bouton | larval stage, with Scer\GAL4^elav-C155

AP-1-2β^JF02963

pupa, with Scer\GAL4^ey.PU

AP-1-2β^JF02963

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\AP1B1

13 of 15

Yes

Hsap\AP2B1

12 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ap1b1

14 of 15

Yes

Mmus\Ap2b1

12 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (7)

Rnor\Ap1b1

11 of 13

Yes

Rnor\Ap2b1

8 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Rnor\LOC103694866

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\ap1b1

10 of 12

Yes

Xtro\ap2b1

7 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (7)

Drer\ap1b1

13 of 15

Yes

Drer\ap2b1

9 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\apb-1

13 of 15

Yes

Cele\apb-3

2 of 15

Cele\copb-1

1 of 15

Arabidopsis thaliana (thale-cress) (4)

Atha\AT4G11380

9 of 9

Yes

Atha\AT4G23460

9 of 9

Yes

Atha\AT5G11490

1 of 9

Yes

Atha\PAT2

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\APL2

11 of 15

Yes

Scer\APL1

6 of 15

Yes

Scer\APL6

1 of 15

Scer\SEC26

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\apl2

10 of 12

Yes

Spom\apl1

6 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

4 of 10

βCOP

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

AP1B1; adaptor related protein complex 1 subunit beta 1

13 of 15

600157

KERATITIS-ICHTHYOSIS-DEAFNESS SYNDROME, AUTOSOMAL RECESSIVE; KIDAR

AP2B1; adaptor related protein complex 2 subunit beta 1

12 of 15

601025

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

AP-1-2β - AP-2α

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - AP-2μ

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - AP-2σ

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - Arf102F

pull down, peptide massfingerprinting

(Christis and Munro, 2012)

AP-1-2β - Arf79F

pull down, peptide massfingerprinting

(Christis and Munro, 2012)

AP-1-2β - Arr2

pull down, western blot

(Orem et al., 2006)

AP-1-2β - Bub1

anti tag coimmunoprecipitation, anti tag western blot

(Yang et al., 2018)

AP-1-2β - BubR1

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2020)

AP-1-2β - Hexim

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - Nak

experimental knowledge based, anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Guruharsha et al., 2011, Yang et al., 2011)

AP-1-2β - Reps

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - Rlip

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - dco

experimental knowledge based

(Guruharsha et al., 2011)

AP-1-2β - ft

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Kwon et al., 2013, Kwon et al., 2013)

AP-1-2β - prd1

anti tag coimmunoprecipitation, anti tag western blot

(Zong et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59282

DroID - A comprehensive database of gene and protein interactions.

FBgn0010380

MIST (protein-protein) - An integrated Molecular Interaction Database

AP-1-2beta

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010380

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Lysosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-64

Cytogenetic map

18E4-18E5

Sequence location

X:19,731,004..19,734,581 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18E4-18E5

Limits computationally determined from genome sequence between P{EP}Sec61γ^EP1511 and P{EP}EP1116&P{EP}EP1344^EP1344

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

18E-18F

(Lloyd et al., 2000)

18E1-18E2

(Pearse, 1993.11.2)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

1-64

(FlyBase, 2016)

1-62.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28328

y¹ v¹; P{TRiP.JF02963}attP2

31707

y¹ v¹; P{TRiP.HM04014}attP2

51342

y¹ w^* AP-1-2β^GH73 P{neoFRT}19A/FM7c

VDRC

v7720

w¹¹¹⁸; P{GD1204}v7720/TM3

v7721

w¹¹¹⁸; P{GD1204}v7721/TM3

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (102)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LP17054

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010380

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010380

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32987

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Choudhury et al., 2016, Camidge and Pearse, 1994)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: AP-1-2β Bap

(Bonifacino et al., 2012.12.21)

Source for database merge of

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Isolated from a Drosophila embryonic cDNA library, using a fragment encoding bases 976 to 1938 of human β-adaptin as a probe.

(Camidge and Pearse, 1994)

A Bap cDNA has been cloned and sequenced.

(Camidge and Pearse, 1994)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32987

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24253

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24253

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010380

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010380

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32987/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010380

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010380

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010380

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12532

Flygut - An atlas of the Drosophila adult midgut

FBgn0010380

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010380

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32987

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG12532

MARRVEL_MODEL - MARRVEL (model organism gene)

32987

modMine - A data warehouse for the modENCODE project

FBgn0010380

Linkouts

BioGRID - A database of protein and genetic interactions.

59282

DroID - A comprehensive database of gene and protein interactions.

FBgn0010380

DRSC - Results frm RNAi screens

FBgn0010380

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010380

FlyMine - An integrated database for Drosophila genomics

FBgn0010380

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Lysosome

MIST (protein-protein) - An integrated Molecular Interaction Database

AP-1-2beta

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (30)

Reported As

Symbol Synonym

AP-1-2-beta

(Hodgson et al., 2019, Yang et al., 2018)

AP-1-2beta

(model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schupbach, 2013.8.12)

AP-1-2β

(Aromolaran et al., 2021, Wang et al., 2021, Fang et al., 2016, Zang et al., 2015)

AP-1/2β

(Bonifacino et al., 2012.12.21)

AP-1β

(Christis and Munro, 2012)

AP-1β1

(Hirst et al., 2009)

AP-2β

(Jha et al., 2012, Orem et al., 2006, Lloyd et al., 2000)

AP-β1

(Ramet et al., 2002)

AP1β1

(Kametaka et al., 2012)

AP2β

(Tang et al., 2020)

AP2β2

(Kametaka et al., 2012)

BAD1

(Camidge and Pearse, 1994, Pearse, 1993.11.2)

BAP

(Kametaka et al., 2012)

Bap

(Zong et al., 2018, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Zhang et al., 2013, Friedman et al., 2011, Yang et al., 2011)

CG12532

(Kolkhof et al., 2017, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Christis and Munro, 2012, Christis and Munro, 2012, Benhra et al., 2011, Cammarato et al., 2011, Perkins et al., 2009, Ni et al., 2008, Legube et al., 2006, Ramet et al., 2002, Boehm, 2001, Verstreken and Bellen, 2000.9.4)

apl1

(Neumann et al., 2010)

apl2

(Neumann et al., 2010)

bap

(Bellen, 2000.12.25)

cg12532

(Boehm and Bonifacino, 2002)

Β-adaptin

(Benhra et al., 2011)

β1/2

(Boehm and Bonifacino, 2001)