FlyBase Gene Report: Dmel\Cyp18a1

General Information

Symbol

Dmel\Cyp18a1

Species

D. melanogaster

Name

Cytochrome P450 18a1

Annotation Symbol

CG6816

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010383

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Eig17-1, cyp18, P450

Key Links

Genomic Location

Cytogenetic map

17D1-17D1

Sequence location

X:18,688,538..18,693,042 [-]

Recombination map

1-60

RefSeq locus

NC_004354 REGION:18688538..18693042

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables steroid hydroxylase activity

inferred from direct assay

(Guittard et al., 2011)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables heme binding

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

enables iron ion binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

enables steroid hydroxylase activity

inferred from biological aspect of ancestor with PANTHER:PTN001210788

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in chorion-containing eggshell formation

inferred from mutant phenotype

(Tootle et al., 2011)

involved_in ecdysteroid catabolic process

inferred from mutant phenotype

(Guittard et al., 2011)

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Rewitz et al., 2010)

involved_in metamorphosis

inferred from mutant phenotype

(Rewitz et al., 2010)

involved_in prepupal development

inferred from mutant phenotype

(Rewitz et al., 2010)

involved_in pupation

inferred from mutant phenotype

(Rewitz et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in exogenous drug catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in organic acid metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in xenobiotic metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in intracellular membrane-bounded organelle

inferred from biological aspect of ancestor with PANTHER:PTN000670347

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CYTOCHROME P450 - CYP2 CLAN

Protein Family (UniProt)

Belongs to the cytochrome P450 family. (Q95078)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

CYTOCHROME P450 - CYP2 CLAN -: Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP2 clan includes D. melanogaster CYP18 and CYP303-307 family genes. CYP2 members have diverse roles and are widely considered as "environmental response genes" in mammalian species. (Adapted from FBrf0248421.)

Protein Function (UniProtKB)

Probably involved in steroid hormones biosynthesis.

(UniProt, Q95078)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp18a1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp18a1-RA

FBtr0074609

NM_167628

2199

538

Cyp18a1-RB

FBtr0074610

NM_078679

3049

538

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cyp18a1-PA

FBpp0074380

61.9

538

7.89

NP_728191

AAN09473

Cyp18a1-PB

FBpp0074381

61.9

538

7.89

NP_523403

AAF48874

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

538 aa isoforms: Cyp18a1-PA, Cyp18a1-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp18a1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyp18a1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism

Comment: maternal

(Chung et al., 2009)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 12 -- 16

embryonic/larval trachea

(Chung et al., 2011)

third instar larval stage

embryonic/larval tracheal system

(Chung et al., 2009)

early third instar larval stage

embryonic/larval epidermis

(Guittard et al., 2011)

embryonic/larval fat body

(Guittard et al., 2011)

embryonic/larval salivary gland

(Guittard et al., 2011)

eye-antennal disc

(Guittard et al., 2011)

gastric caecum

(Guittard et al., 2011)

embryonic/larval midgut

(Guittard et al., 2011)

ring gland

(Ou et al., 2016, Guittard et al., 2011)

prothoracic gland

(Guittard et al., 2011)

oogenesis stage S11 -- S13 & adult stage | female

follicle cell

(Peters et al., 2013)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

Comment: higher levels at 48-60 hours than at 88-96 hours post-hatching

(Guittard et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp18a1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp18a1

View exonic expression by tissue for Dmel\Cyp18a1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010383

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010383

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6816-RB;CG6816-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6816

Flygut - An atlas of the Drosophila adult midgut

FBgn0010383

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cyp18a1

Stages(s) 4-6
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp18a1

Transgenic constructs containing regulatory region of Cyp18a1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel7463

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | adult stage | recessive

Cyp18a1^null644

lethal | P-stage, with Scer\GAL4^Cyp6g1.HR

Cyp18a1^UAS.cGa

lethal | P-stage, with Scer\GAL4^phm.PG

Cyp18a1^dsRNA.UAS

lethal | P-stage, with Scer\GAL4^Tub.PU

Cyp18a1^dsRNA.UAS

lethal | P-stage | recessive

Cyp18a1^null644

lethal | recessive

Cyp18a1^null748

lethal | third instar larval stage, with Scer\GAL4^Cyp6g1.HR

Cyp18a1^UAS.cGa

lethal | third instar larval stage, with Scer\GAL4^phm.PG

Cyp18a1^dsRNA.UAS

lethal | third instar larval stage, with Scer\GAL4^Tub.PU

Cyp18a1^dsRNA.UAS

lethal - all die before end of pupal stage

Cyp18a1¹

lethal - all die before end of pupal stage, with Scer\GAL4^da.G32

Cyp18a1^GD1176

lethal - all die during embryonic stage, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

lethal - all die during embryonic stage, with Scer\GAL4^phm.PG

Cyp18a1^UAS.cGa

lethal - all die during embryonic stage, with Scer\GAL4^Tub.PU

Cyp18a1^UAS.cGa

viable

Cyp18a1^d07122

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyp18a1^GD1176

viable, with Scer\GAL4^pnr-MD237

Cyp18a1^GD1176

viable, with Scer\GAL4^tin.CΔ4

Cyp18a1^GD1176

Sterility

Allele

fertile

Cyp18a1^d07122

Other Phenotypes

Allele

abnormal developmental rate | P-stage

Cyp18a1^null644

abnormal developmental rate | third instar larval stage

Cyp18a1^null644

abnormal developmental rate | third instar larval stage, with Scer\GAL4^phm.PG

Cyp18a1^dsRNA.UAS

abnormal developmental rate | third instar larval stage, with Scer\GAL4^Tub.PU

Cyp18a1^dsRNA.UAS

abnormal flight, with Scer\GAL4^Mef2.PR

Cyp18a1^GD1176

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^Cyp6g1.HR

Cyp18a1^UAS.cGa

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^phm.PG

Cyp18a1^dsRNA.UAS

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^Tub.PU

Cyp18a1^dsRNA.UAS

some die during embryonic stage, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

some die during embryonic stage, with Scer\GAL4^phm.PG

Cyp18a1^UAS.cGa

some die during embryonic stage, with Scer\GAL4^Tub.PU

Cyp18a1^UAS.cGa

some die during pupal stage

Cyp18a1¹

some die during pupal stage, with Scer\GAL4^da.G32

Cyp18a1^GD1176

Phenotype manifest in

Allele

adult head | pupal stage

Cyp18a1¹

adult head | pupal stage, with Scer\GAL4^da.G32

Cyp18a1^GD1176

cuticle | third instar larval stage, with Scer\GAL4^Cyp6g1.HR

Cyp18a1^UAS.cGa

cuticle | third instar larval stage, with Scer\GAL4^phm.PG

Cyp18a1^dsRNA.UAS

denticle belt, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

embryonic/first instar larval cuticle, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

embryonic/larval midgut primordium, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

embryonic dorsal epidermis, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

embryonic head, with Scer\GAL4^da.G32

Cyp18a1^UAS.cRa

leg | pupal stage, with Scer\GAL4^da.G32

Cyp18a1^GD1176

leg | pupal stage, with Scer\GAL4^da.G32, Scer\GAL80^ts.αTub84B

Cyp18a1^GD1176

metathoracic leg | pupal stage

Cyp18a1¹

midgut | third instar larval stage, with Scer\GAL4^Cyp6g1.HR

Cyp18a1^UAS.cGa

midgut | third instar larval stage, with Scer\GAL4^phm.PG

Cyp18a1^dsRNA.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CYP2J2

9 of 15

Yes

Hsap\CYP2U1

9 of 15

Yes

Hsap\CYP2B6

7 of 15

Yes

Hsap\CYP2C8

7 of 15

Yes

Hsap\CYP2C9

7 of 15

Yes

Hsap\CYP2C19

7 of 15

Yes

Hsap\CYP2D6

7 of 15

Yes

Hsap\CYP2A6

6 of 15

Yes

Hsap\CYP2A13

6 of 15

Yes

Hsap\CYP2C18

6 of 15

Yes

Hsap\CYP2R1

6 of 15

Yes

Hsap\CYP2A7

5 of 15

Yes

Hsap\CYP2E1

4 of 15

Yes

Hsap\CYP2F1

4 of 15

Yes

Hsap\CYP2S1

4 of 15

Yes

Hsap\CYP2D7

3 of 15

Yes

Hsap\CYP2W1

2 of 15

Yes

Hsap\CYP1A1

1 of 15

Yes

Hsap\CYP1A2

1 of 15

Yes

Hsap\CYP1B1

1 of 15

Hsap\CYP2G1P

1 of 15

Yes

Hsap\CYP17A1

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (53)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cyp2u1

9 of 15

Yes

Mmus\Cyp2j6

8 of 15

Yes

Mmus\Cyp2b9

7 of 15

Yes

Mmus\Cyp2b10

7 of 15

Yes

Mmus\Cyp2b13

7 of 15

Yes

Mmus\Cyp2b19

7 of 15

Yes

Mmus\Cyp2b23

7 of 15

Yes

Mmus\Cyp2c70

7 of 15

Yes

Mmus\Cyp2j5

7 of 15

Yes

Mmus\Cyp2j9

7 of 15

Yes

Mmus\Cyp2j11

7 of 15

Yes

Mmus\Cyp2j13

7 of 15

Yes

Mmus\Cyp2a4

6 of 15

Yes

Mmus\Cyp2a5

6 of 15

Yes

Mmus\Cyp2a12

6 of 15

Yes

Mmus\Cyp2a22

6 of 15

Yes

Mmus\Cyp2c23

6 of 15

Yes

Mmus\Cyp2c29

6 of 15

Yes

Mmus\Cyp2c37

6 of 15

Yes

Mmus\Cyp2c38

6 of 15

Yes

Mmus\Cyp2c39

6 of 15

Yes

Mmus\Cyp2c40

6 of 15

Yes

Mmus\Cyp2c55

6 of 15

Yes

Mmus\Cyp2c65

6 of 15

Yes

Mmus\Cyp2c66

6 of 15

Yes

Mmus\Cyp2d22

6 of 15

Yes

Mmus\Cyp2d26

6 of 15

Yes

Mmus\Cyp2r1

6 of 15

Yes

Mmus\Cyp2c50

5 of 15

Yes

Mmus\Cyp2c54

5 of 15

Yes

Mmus\Cyp2c67

5 of 15

Yes

Mmus\Cyp2c68

5 of 15

Yes

Mmus\Cyp2d9

5 of 15

Yes

Mmus\Cyp2d10

5 of 15

Yes

Mmus\Cyp2d12

5 of 15

Yes

Mmus\Cyp2g1

5 of 15

Yes

Mmus\Cyp2j8

5 of 15

Yes

Mmus\Cyp2j12

5 of 15

Yes

Mmus\Cyp2c69

4 of 15

Yes

Mmus\Cyp2d11

4 of 15

Yes

Mmus\Cyp2d34

4 of 15

Yes

Mmus\Cyp2e1

4 of 15

Yes

Mmus\Cyp2f2

4 of 15

Yes

Mmus\Cyp2s1

4 of 15

Yes

Mmus\Cyp2ab1

2 of 15

Mmus\Cyp2t4

2 of 15

Yes

Mmus\Cyp2w1

2 of 15

Yes

Mmus\Cyp1a1

1 of 15

Yes

Mmus\Cyp1a2

1 of 15

Yes

Mmus\Cyp1b1

1 of 15

Mmus\Cyp2d40

1 of 15

Mmus\Cyp2j7

1 of 15

Yes

Mmus\Cyp17a1

1 of 15

Yes

Rattus norvegicus (Norway rat) (51)

Rnor\Cyp2u1

8 of 13

Yes

Rnor\Cyp2b3

7 of 13

Yes

Rnor\Cyp2a1

6 of 13

Yes

Rnor\Cyp2b15

6 of 13

Yes

Rnor\Cyp2c23

6 of 13

Yes

Rnor\Cyp2b1

5 of 13

Yes

Rnor\Cyp2b12

5 of 13

Yes

Rnor\Cyp2b21

5 of 13

Yes

Rnor\Cyp2c6v1

5 of 13

Yes

Rnor\Cyp2c7

5 of 13

Yes

Rnor\Cyp2c22

5 of 13

Yes

Rnor\Cyp2c24

5 of 13

Yes

Rnor\Cyp2d2

5 of 13

Yes

Rnor\Cyp2d3

5 of 13

Yes

Rnor\Cyp2d4

5 of 13

Yes

Rnor\LOC100361492

5 of 13

Yes

Rnor\Cyp2a3

4 of 13

Yes

Rnor\Cyp2c11

4 of 13

Yes

Rnor\Cyp2c12

4 of 13

Yes

Rnor\Cyp2c13

4 of 13

Yes

Rnor\Cyp2d1

4 of 13

Yes

Rnor\Cyp2d5

4 of 13

Yes

Rnor\Cyp2e1

4 of 13

Yes

Rnor\Cyp2g1

4 of 13

Yes

Rnor\Cyp2j3

4 of 13

Yes

Rnor\Cyp2j16

4 of 13

Yes

Rnor\Cyp2s1

4 of 13

Yes

Rnor\LOC100910127

4 of 13

Yes

Rnor\LOC103691092

4 of 13

Yes

Rnor\Cyp2a2

3 of 13

Yes

Rnor\Cyp2ab1

3 of 13

Yes

Rnor\Cyp2b2

3 of 13

Yes

Rnor\Cyp2f4

3 of 13

Yes

Rnor\Cyp2j4

3 of 13

Yes

Rnor\Cyp2j10

3 of 13

Yes

Rnor\Cyp2c80

2 of 13

Yes

Rnor\Cyp2r1

2 of 13

Yes

Rnor\Cyp2t1

2 of 13

Yes

Rnor\LOC100361547

2 of 13

Yes

Rnor\Cyp1a1

1 of 13

Yes

Rnor\Cyp1a2

1 of 13

Yes

Rnor\Cyp1b1

1 of 13

Rnor\Cyp2ac1

1 of 13

Yes

Rnor\Cyp2w1

1 of 13

Rnor\Cyp17a1

1 of 13

Yes

Rnor\Ednra

1 of 13

Yes

Rnor\LOC100912265

1 of 13

Yes

Rnor\LOC100912642

1 of 13

Yes

Rnor\LOC103691072

1 of 13

Yes

Rnor\LOC108348266

1 of 13

Yes

Rnor\LOC108351992

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (61)

Xtro\cyp2u1

5 of 12

Yes

Xtro\cyp2c8.2

4 of 12

Yes

Xtro\cyp2f2

4 of 12

Yes

Xtro\LOC100497184

4 of 12

Yes

Xtro\MGC69353

4 of 12

Yes

Xtro\cyp2c18

3 of 12

Yes

Xtro\LOC100490015

3 of 12

Yes

Xtro\LOC100490476

3 of 12

Yes

Xtro\cyp2a6

2 of 12

Yes

Xtro\cyp2a13

2 of 12

Yes

Xtro\cyp2b6

2 of 12

Yes

Xtro\cyp2d6

2 of 12

Yes

Xtro\cyp2e1

2 of 12

Yes

Xtro\cyp2g1p

2 of 12

Yes

Xtro\cyp2r1

2 of 12

Yes

Xtro\cyp2w1

2 of 12

Yes

Xtro\LOC548374

2 of 12

Yes

Xtro\LOC619584

2 of 12

Yes

Xtro\LOC100036663

2 of 12

Yes

Xtro\LOC100145323

2 of 12

Yes

Xtro\LOC100145541

2 of 12

Yes

Xtro\LOC100145695

2 of 12

Yes

Xtro\LOC100486127

2 of 12

Yes

Xtro\LOC100495359

2 of 12

Yes

Xtro\MGC69416

2 of 12

Yes

Xtro\MGC107969

2 of 12

Yes

Xtro\cyp1a1

1 of 12

Yes

Xtro\cyp2c8.1

1 of 12

Yes

Xtro\cyp2c19

1 of 12

Yes

Xtro\cyp2f1

1 of 12

Yes

Xtro\cyp2j2

1 of 12

Yes

Xtro\LOC100124950

1 of 12

Yes

Xtro\LOC100145084

1 of 12

Yes

Xtro\LOC100145285

1 of 12

Yes

Xtro\LOC100170416

1 of 12

Yes

Xtro\LOC100486002

1 of 12

Yes

Xtro\LOC100490986

1 of 12

Yes

Xtro\LOC100491441

1 of 12

Yes

Xtro\LOC100491603

1 of 12

Yes

Xtro\LOC100491773

1 of 12

Yes

Xtro\LOC100491837

1 of 12

Yes

Xtro\LOC100492165

1 of 12

Yes

Xtro\LOC100493194

1 of 12

Yes

Xtro\LOC100493754

1 of 12

Yes

Xtro\LOC100493928

1 of 12

Yes

Xtro\LOC100494424

1 of 12

Yes

Xtro\LOC100494435

1 of 12

Yes

Xtro\LOC100494741

1 of 12

Yes

Xtro\LOC100495056

1 of 12

Yes

Xtro\LOC100495200

1 of 12

Yes

Xtro\LOC100495517

1 of 12

Yes

Xtro\LOC100496861

1 of 12

Yes

Xtro\LOC100497503

1 of 12

Yes

Xtro\LOC100497808

1 of 12

Yes

Xtro\LOC101730237

1 of 12

Yes

Xtro\LOC101730623

1 of 12

Yes

Xtro\LOC101731204

1 of 12

Yes

Xtro\LOC105947503

1 of 12

Yes

Xtro\LOC108644451

1 of 12

Yes

Xtro\LOC108647710

1 of 12

Yes

Xtro\MGC108322

1 of 12

Yes

Danio rerio (Zebrafish) (53)

Drer\cyp2u1

9 of 15

Yes

Drer\cyp2aa12

7 of 15

Yes

Drer\cyp2p6

7 of 15

Yes

Drer\cyp2p7

7 of 15

Yes

Drer\cyp2p8

7 of 15

Yes

Drer\cyp2aa3

6 of 15

Yes

Drer\cyp2aa8

6 of 15

Yes

Drer\cyp2aa11

6 of 15

Yes

Drer\cyp2ad2

6 of 15

Yes

Drer\cyp2j20

6 of 15

Yes

Drer\cyp2n13

6 of 15

Yes

Drer\cyp2p10

6 of 15

Yes

Drer\cyp2aa1

5 of 15

Yes

Drer\cyp2ad6

5 of 15

Yes

Drer\cyp2k6

5 of 15

Yes

Drer\cyp2k8

5 of 15

Yes

Drer\cyp2r1

5 of 15

Yes

Drer\cyp2aa2

4 of 15

Yes

Drer\cyp2aa7

4 of 15

Yes

Drer\cyp2aa9

4 of 15

Yes

Drer\cyp2k16

4 of 15

Yes

Drer\cyp2k17

4 of 15

Yes

Drer\cyp2k18

4 of 15

Yes

Drer\cyp2k22

4 of 15

Yes

Drer\cyp2x7

4 of 15

Yes

Drer\cyp2x9

4 of 15

Yes

Drer\cyp2x12

4 of 15

Yes

Drer\si:zfos-411a11.2

4 of 15

Yes

Drer\cyp2aa4

3 of 15

Yes

Drer\cyp2ae1

3 of 15

Yes

Drer\cyp2k20

3 of 15

Yes

Drer\cyp2k21

3 of 15

Yes

Drer\cyp2k31

3 of 15

Yes

Drer\cyp2p9

3 of 15

Yes

Drer\cyp2x6

3 of 15

Yes

Drer\cyp2x8

3 of 15

Yes

Drer\cyp2x10.2

3 of 15

Yes

Drer\cyp2y3

3 of 15

Yes

Drer\LOC100148115

3 of 15

Yes

Drer\cyp2aa6

2 of 15

Yes

Drer\cyp2ad3

2 of 15

Yes

Drer\cyp2k19

2 of 15

Yes

Drer\cyp2v1

2 of 15

Yes

Drer\cyp17a2

2 of 15

Yes

Drer\si:dkey-286h2.3

2 of 15

Yes

Drer\zgc:101048

2 of 15

Yes

Drer\cyp1a

1 of 15

Yes

Drer\cyp1b1

1 of 15

Yes

Drer\cyp1c1

1 of 15

Yes

Drer\cyp1c2

1 of 15

Yes

Drer\cyp1d1

1 of 15

Yes

Drer\cyp17a1

1 of 15

Yes

Drer\LOC103909721

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (46)

Cele\cyp-33C3

9 of 15

Yes

Cele\cyp-33E1

9 of 15

Yes

Cele\cyp-33E2

9 of 15

Yes

Cele\cyp-33C1

8 of 15

Yes

Cele\cyp-33C2

8 of 15

Yes

Cele\cyp-33C4

8 of 15

Yes

Cele\cyp-33C5

8 of 15

Yes

Cele\cyp-33C6

8 of 15

Yes

Cele\cyp-33C7

8 of 15

Yes

Cele\cyp-33C8

8 of 15

Yes

Cele\cyp-33C11

8 of 15

Yes

Cele\cyp-33C12

8 of 15

Yes

Cele\cyp-33D1

8 of 15

Yes

Cele\cyp-33D3

8 of 15

Yes

Cele\cyp-33A1

7 of 15

Yes

Cele\cyp-33C9

7 of 15

Yes

Cele\cyp-33B1

6 of 15

Yes

Cele\cyp-34A5

5 of 15

Yes

Cele\cyp-34A7

5 of 15

Yes

Cele\cyp-34A8

5 of 15

Yes

Cele\cyp-36A1

5 of 15

Yes

Cele\cyp-14A1

4 of 15

Yes

Cele\cyp-14A2

4 of 15

Yes

Cele\cyp-14A3

4 of 15

Yes

Cele\cyp-14A5

4 of 15

Yes

Cele\cyp-23A1

4 of 15

Yes

Cele\cyp-33E3

4 of 15

Yes

Cele\cyp-34A1

4 of 15

Yes

Cele\cyp-34A2

4 of 15

Yes

Cele\cyp-34A4

4 of 15

Yes

Cele\cyp-34A6

4 of 15

Yes

Cele\cyp-34A9

4 of 15

Yes

Cele\cyp-34A10

4 of 15

Yes

Cele\cyp-35A1

4 of 15

Yes

Cele\cyp-35A2

4 of 15

Yes

Cele\cyp-35A3

4 of 15

Yes

Cele\cyp-35A4

4 of 15

Yes

Cele\cyp-35A5

4 of 15

Yes

Cele\cyp-35B1

4 of 15

Yes

Cele\cyp-35B2

4 of 15

Yes

Cele\cyp-35B3

4 of 15

Yes

Cele\cyp-35C1

4 of 15

Yes

Cele\cyp-35D1

4 of 15

Yes

Cele\daf-9

3 of 15

Cele\cyp-14A4

2 of 15

Yes

Cele\cyp-34A3

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (151)

Atha\FAH1

5 of 9

Yes

Atha\C4H

4 of 9

Yes

Atha\CYP71A22

4 of 9

Yes

Atha\CYP71A23

4 of 9

Yes

Atha\CYP71A25

4 of 9

Yes

Atha\CYP71B2

4 of 9

Yes

Atha\CYP71B4

4 of 9

Yes

Atha\CYP71B5

4 of 9

Yes

Atha\CYP71B6

4 of 9

Yes

Atha\CYP71B7

4 of 9

Yes

Atha\CYP71B11

4 of 9

Yes

Atha\CYP71B13

4 of 9

Yes

Atha\CYP71B14

4 of 9

Yes

Atha\CYP71B21

4 of 9

Yes

Atha\CYP71B22

4 of 9

Yes

Atha\CYP71B23

4 of 9

Yes

Atha\CYP71B28

4 of 9

Yes

Atha\CYP71B38

4 of 9

Yes

Atha\CYP76C1

4 of 9

Yes

Atha\CYP76C2

4 of 9

Yes

Atha\CYP76C3

4 of 9

Yes

Atha\CYP76C4

4 of 9

Yes

Atha\CYP76C6

4 of 9

Yes

Atha\CYP81F2

4 of 9

Yes

Atha\CYP81F3

4 of 9

Yes

Atha\CYP81F4

4 of 9

Yes

Atha\CYP83B1

4 of 9

Yes

Atha\CYP84A4

4 of 9

Yes

Atha\CYP91A2

4 of 9

Yes

Atha\CYP703A2

4 of 9

Yes

Atha\CYP706A4

4 of 9

Yes

Atha\CYP706A6

4 of 9

Yes

Atha\CYP71A12

3 of 9

Yes

Atha\CYP71A13

3 of 9

Yes

Atha\CYP71A14

3 of 9

Yes

Atha\CYP71A18

3 of 9

Yes

Atha\CYP71A19

3 of 9

Yes

Atha\CYP71A20

3 of 9

Yes

Atha\CYP71A21

3 of 9

Yes

Atha\CYP71A24

3 of 9

Yes

Atha\CYP71A26

3 of 9

Yes

Atha\CYP71B3

3 of 9

Yes

Atha\CYP71B8

3 of 9

Yes

Atha\CYP71B9

3 of 9

Yes

Atha\CYP71B10

3 of 9

Yes

Atha\CYP71B12

3 of 9

Yes

Atha\CYP71B16

3 of 9

Yes

Atha\CYP71B17

3 of 9

Yes

Atha\CYP71B19

3 of 9

Yes

Atha\CYP71B20

3 of 9

Yes

Atha\CYP71B24

3 of 9

Yes

Atha\CYP71B25

3 of 9

Yes

Atha\CYP71B26

3 of 9

Yes

Atha\CYP71B29

3 of 9

Yes

Atha\CYP71B31

3 of 9

Yes

Atha\CYP71B34

3 of 9

Yes

Atha\CYP71B35

3 of 9

Yes

Atha\CYP71B36

3 of 9

Yes

Atha\CYP71B37

3 of 9

Yes

Atha\CYP76C7

3 of 9

Yes

Atha\CYP78A6

3 of 9

Yes

Atha\CYP81D2

3 of 9

Yes

Atha\CYP81D4

3 of 9

Yes

Atha\CYP81D5

3 of 9

Yes

Atha\CYP81D7

3 of 9

Yes

Atha\CYP81D8

3 of 9

Yes

Atha\CYP81H1

3 of 9

Yes

Atha\CYP83A1

3 of 9

Yes

Atha\CYP98A3

3 of 9

Yes

Atha\CYP98A8

3 of 9

Yes

Atha\CYP98A9

3 of 9

Yes

Atha\CYP705A3

3 of 9

Yes

Atha\CYP705A12

3 of 9

Yes

Atha\CYP706A2

3 of 9

Yes

Atha\CYP706A3

3 of 9

Yes

Atha\CYP706A5

3 of 9

Yes

Atha\CYP706A7

3 of 9

Yes

Atha\CYP712A1

3 of 9

Yes

Atha\PAD3

3 of 9

Yes

Atha\TT7

3 of 9

Yes

Atha\AT1G66540

2 of 9

Yes

Atha\AT2G12190

2 of 9

Yes

Atha\CYP71A15

2 of 9

Yes

Atha\CYP71A16

2 of 9