Gtp-bp, GTP-binding protein
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Heterodimer of SrpRalpha and SrpRbeta.
The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SrpRα using the Feature Mapper tool.
In germ band extended embryos, Gtp-bp protein is detected in cells dorsal to the ectoderm and is distributed in a continuous layer from the stomodeal opening to the end of the germ band. It is also found at the anterior tip of the clypeolabrum and in the posterior gut. During germ band retraction, it becomes confined within the ventral midline, dorsal to the delaminating neuroblasts. The midline cells expressing Gtp-bp protein send a broad process across the midline just ventral to the yolk sac to the contralateral neuromere. At this stage, a single cell in each neuromere is detected. Later, protein is detected on axons that cross the midline and in other cells and processes in lateral regions of each neuromere. Starting in stage 13, Gtp-bp protein is detected in ventral, lateral and dorsal sensilla of the PNS. In later embryos, protein is detected in the intersegmental nerve and the segmental nerve on axons and on subsets of PNS cell soma.
GBrowse - Visual display of RNA-Seq signalsView Dmel\SrpRα in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: SrpRα Gtp-bp
Source for merge of Gtp-bp BEST:CK00309 was sequence comparison ( date:030820 ).