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Gene Dmel\Gtp-bp

General Information
Symbol	Dmel\Gtp-bp	Species	D. melanogaster
Name	GTP-binding protein	Annotation symbol	CG2522
Feature type	protein_coding_gene	FlyBase ID	FBgn0010391
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	SrpRα
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10A6-10A6	Sequence location	X:11,020,908..11,023,136 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene GTP-binding protein is referred to in FlyBase by the symbol Dmel\Gtp-bp (CG2522, FBgn0010391). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: signal recognition particle binding. There is experimental evidence that it is involved in the biological process: regulation of protein secretion; axonogenesis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; Longin-like; Signal recognition particle receptor, alpha subunit, N-terminal; Signal recognition particle, SRP54 subunit, GTPase; Signal recognition particle, SRP54 subunit, helical bundle. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval hindgut, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, adult ovary, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639135_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gtp-bp. Gene sequence location is X:11020908..11023136.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN20777 HFA20251
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A6-10A6   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References 11C-11D     (Fredieu, 1993.12.20) 11C-11D   (determined by in situ hybridisation)   (Fredieu and Mahowald, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gtp-bp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gtp-bp-RA FBtr0073480  NM_080148   2074   614
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gtp-bp-PA   FBpp0073336   67.8   614   6.80     NP_524887   AAF48002
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Signal recognition particle, SRP54 subunit, GTPase (IPR000897) ATPase, AAA+ type, core (IPR003593) Signal recognition particle, SRP54 subunit, helical bundle (IPR013822) Signal recognition particle receptor, alpha subunit, N-terminal (IPR007222) Longin-like (IPR011012)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142160   AA142161   AA391187   AA695501   AA696867   AA802475   AA817477   AA941487   AE014298 AAF48002   AI107591   AI109038   AI238528   AI257388   AI294171   AI295141   AI297065   AI389419   AI405887   AI518715   AI534216   AI544140   AI546398   AW942807   AY061329 AAL28877   AY231715   BF494497   BF502193   BG636399   BG636751   BG637223   BI162904   BI168403   BI230995   BI234996   BI236850   BI239788   BI241996   BI353216   BI354586   BI356287   BI370479   BI373556   BI626876   BI639338   BI639443   BI639675   BI641862   BT044198   CK604661   CK605273   CK660355   CK660896   CO186088   CO188064   CO339115   EC053442   EC053923   EC053948   EC053949   EC054398   EC054960   EC061639   EC069520   EC083664   EC084569   EC206675   EC229672   ES690329   ES690357   ES690378   ES690381   EV580401   S65640 AAB27926
UniProtKB/Swiss-Prot	Q9U5L1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   salivary gland body primordium   (Abrams and Andrew, 2005) embryonic stage 12   ventral midline | dorsal & segmentally repeated   (Fredieu and Mahowald, 1993) embryonic stage 13 -- 14   presumptive embryonic salivary gland   (Abrams and Andrew, 2005) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism   (Fredieu and Mahowald, 1993)
Additional Descriptive Data
	Gtp-bp transcripts are expressed at high levels throughout embryogenesis with a peak between 12 and 18 hrs. They are found lateral to the dorsal-most regions of the ventral midline and show a segmentally repeating pattern. (Fredieu and Mahowald, 1993)
Marker for
	embryonic salivary gland salivary gland body primordium
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   ventral midline   (Fredieu and Mahowald, 1993) embryonic/larval digestive system   (Fredieu and Mahowald, 1993) stomodeum   (Fredieu and Mahowald, 1993) embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   (Fredieu and Mahowald, 1993) embryonic stage 16 -- 17   intersegmental nerve   (Fredieu and Mahowald, 1993) peripheral nervous system   (Fredieu and Mahowald, 1993) segmental nerve   (Fredieu and Mahowald, 1993) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference   neuroblast   (Fredieu and Mahowald, 1993) Comment:cultured neuroblasts
Additional Descriptive Data
	In germ band extended embryos, Gtp-bp protein is detected in cells dorsal to the ectoderm and is distributed in a continuous layer from the stomodeal opening to the end of the germ band. It is also found at the anterior tip of the clypeolabrum and in the posterior gut. During germ band retraction, it becomes confined within the ventral midline, dorsal to the delaminating neuroblasts. The midline cells expressing Gtp-bp protein send a broad process across the midline just ventral to the yolk sac to the contralateral neuromere. At this stage, a single cell in each neuromere is detected. Later, protein is detected on axons that cross the midline and in other cells and processes in lateral regions of each neuromere. Starting in stage 13, Gtp-bp protein is detected in ventral, lateral and dorsal sensilla of the PNS. In later embryos, protein is detected in the intersegmental nerve and the segmental nerve on axons and on subsets of PNS cell soma. (Fredieu and Mahowald, 1993)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010391    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010391 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010391 expression level Developmental Stage   Expression Level embryo 00-02hr    5704 embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr    4179 embryo 08-10hr    6583 embryo 10-12hr    14075 embryo 12-14hr    7453 embryo 14-16hr    15189 embryo 16-18hr    9544 embryo 18-20hr    5567 embryo 20-22hr    3551 embryo 22-24hr    2794 larva L1    6858 larva L2    9673 larva L3 12hr old    7797 larva L3 puffstage 1-2    4555 larva L3 puffstage 3-6    4807 larva L3 puffstage 7-9    4264 white prepupae new    4524 white prepupae 12hr    2910 white prepupae 24hr    4037 pupae 2d postWPP    4539 pupae 3d postWPP    2865 pupae 4d postWPP    3429 adult male 01day    4131 adult male 05day    4843 adult male 30day    6314 adult female 01day    7263 adult female 05day    5696 adult female 30day    6747 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5704) embryo 02-04hr  (572) embryo 04-06hr  (930) embryo 06-08hr  (4179) embryo 08-10hr  (6583) embryo 10-12hr  (14075) embryo 12-14hr  (7453) embryo 14-16hr  (15189) embryo 16-18hr  (9544) embryo 18-20hr  (5567) embryo 20-22hr  (3551) embryo 22-24hr  (2794) larva L1  (6858) larva L2  (9673) larva L3 12hr old  (7797) larva L3 puffstage 1-2  (4555) larva L3 puffstage 3-6  (4807) larva L3 puffstage 7-9  (4264) white prepupae new  (4524) white prepupae 12hr  (2910) white prepupae 24hr  (4037) pupae 2d postWPP  (4539) pupae 3d postWPP  (2865) pupae 4d postWPP  (3429) adult male 01day  (4131) adult male 05day  (4843) adult male 30day  (6314) adult female 01day  (7263) adult female 05day  (5696) adult female 30day  (6747) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5704) embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr  (4179) embryo 08-10hr  (6583) embryo 10-12hr  (14075) embryo 12-14hr  (7453) embryo 14-16hr  (15189) embryo 16-18hr  (9544) embryo 18-20hr  (5567) embryo 20-22hr  (3551) embryo 22-24hr  (2794) larva L1  (6858) larva L2  (9673) larva L3 12hr old  (7797) larva L3 puffstage 1-2  (4555) larva L3 puffstage 3-6  (4807) larva L3 puffstage 7-9  (4264) white prepupae new  (4524) white prepupae 12hr  (2910) white prepupae 24hr  (4037) pupae 2d postWPP  (4539) pupae 3d postWPP  (2865) pupae 4d postWPP  (3429) adult male 01day  (4131) adult male 05day  (4843) adult male 30day  (6314) adult female 01day  (7263) adult female 05day  (5696) adult female 30day  (6747) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5704 embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr    4179 embryo 08-10hr    6583 embryo 10-12hr  (14075) embryo 12-14hr    7453 embryo 14-16hr  (15189) embryo 16-18hr    9544 embryo 18-20hr    5567 embryo 20-22hr    3551 embryo 22-24hr    2794 larva L1    6858 larva L2    9673 larva L3 12hr old    7797 larva L3 puffstage 1-2    4555 larva L3 puffstage 3-6    4807 larva L3 puffstage 7-9    4264 white prepupae new    4524 white prepupae 12hr    2910 white prepupae 24hr    4037 pupae 2d postWPP    4539 pupae 3d postWPP    2865 pupae 4d postWPP    3429 adult male 01day    4131 adult male 05day    4843 adult male 30day    6314 adult female 01day    7263 adult female 05day    5696 adult female 30day    6747 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5704 embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr    4179 embryo 08-10hr    6583 embryo 10-12hr    14075 embryo 12-14hr    7453 embryo 14-16hr    15189 embryo 16-18hr    9544 embryo 18-20hr    5567 embryo 20-22hr    3551 embryo 22-24hr    2794 larva L1    6858 larva L2    9673 larva L3 12hr old    7797 larva L3 puffstage 1-2    4555 larva L3 puffstage 3-6    4807 larva L3 puffstage 7-9    4264 white prepupae new    4524 white prepupae 12hr    2910 white prepupae 24hr    4037 pupae 2d postWPP    4539 pupae 3d postWPP    2865 pupae 4d postWPP    3429 adult male 01day    4131 adult male 05day    4843 adult male 30day    6314 adult female 01day    7263 adult female 05day    5696 adult female 30day    6747 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010391 expression level Developmental Stage   Expression Level embryo 00-02hr    5704 embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr    4179 embryo 08-10hr    6583 embryo 10-12hr    14075 embryo 12-14hr    7453 embryo 14-16hr    15189 embryo 16-18hr    9544 embryo 18-20hr    5567 embryo 20-22hr    3551 embryo 22-24hr    2794 larva L1    6858 larva L2    9673 larva L3 12hr old    7797 larva L3 puffstage 1-2    4555 larva L3 puffstage 3-6    4807 larva L3 puffstage 7-9    4264 white prepupae new    4524 white prepupae 12hr    2910 white prepupae 24hr    4037 pupae 2d postWPP    4539 pupae 3d postWPP    2865 pupae 4d postWPP    3429 adult male 01day    4131 adult male 05day    4843 adult male 30day    6314 adult female 01day    7263 adult female 05day    5696 adult female 30day    6747 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5704) embryo 02-04hr  (572) embryo 04-06hr  (930) embryo 06-08hr  (4179) embryo 08-10hr  (6583) embryo 10-12hr  (14075) embryo 12-14hr  (7453) embryo 14-16hr  (15189) embryo 16-18hr  (9544) embryo 18-20hr  (5567) embryo 20-22hr  (3551) embryo 22-24hr  (2794) larva L1  (6858) larva L2  (9673) larva L3 12hr old  (7797) larva L3 puffstage 1-2  (4555) larva L3 puffstage 3-6  (4807) larva L3 puffstage 7-9  (4264) white prepupae new  (4524) white prepupae 12hr  (2910) white prepupae 24hr  (4037) pupae 2d postWPP  (4539) pupae 3d postWPP  (2865) pupae 4d postWPP  (3429) adult male 01day  (4131) adult male 05day  (4843) adult male 30day  (6314) adult female 01day  (7263) adult female 05day  (5696) adult female 30day  (6747) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5704) embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr  (4179) embryo 08-10hr  (6583) embryo 10-12hr  (14075) embryo 12-14hr  (7453) embryo 14-16hr  (15189) embryo 16-18hr  (9544) embryo 18-20hr  (5567) embryo 20-22hr  (3551) embryo 22-24hr  (2794) larva L1  (6858) larva L2  (9673) larva L3 12hr old  (7797) larva L3 puffstage 1-2  (4555) larva L3 puffstage 3-6  (4807) larva L3 puffstage 7-9  (4264) white prepupae new  (4524) white prepupae 12hr  (2910) white prepupae 24hr  (4037) pupae 2d postWPP  (4539) pupae 3d postWPP  (2865) pupae 4d postWPP  (3429) adult male 01day  (4131) adult male 05day  (4843) adult male 30day  (6314) adult female 01day  (7263) adult female 05day  (5696) adult female 30day  (6747) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5704 embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr    4179 embryo 08-10hr    6583 embryo 10-12hr  14075 embryo 12-14hr    7453 embryo 14-16hr  15189 embryo 16-18hr    9544 embryo 18-20hr    5567 embryo 20-22hr    3551 embryo 22-24hr    2794 larva L1    6858 larva L2    9673 larva L3 12hr old    7797 larva L3 puffstage 1-2    4555 larva L3 puffstage 3-6    4807 larva L3 puffstage 7-9    4264 white prepupae new    4524 white prepupae 12hr    2910 white prepupae 24hr    4037 pupae 2d postWPP    4539 pupae 3d postWPP    2865 pupae 4d postWPP    3429 adult male 01day    4131 adult male 05day    4843 adult male 30day    6314 adult female 01day    7263 adult female 05day    5696 adult female 30day    6747 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5704 embryo 02-04hr    572 embryo 04-06hr    930 embryo 06-08hr    4179 embryo 08-10hr    6583 embryo 10-12hr    14075 embryo 12-14hr    7453 embryo 14-16hr    15189 embryo 16-18hr    9544 embryo 18-20hr    5567 embryo 20-22hr    3551 embryo 22-24hr    2794 larva L1    6858 larva L2    9673 larva L3 12hr old    7797 larva L3 puffstage 1-2    4555 larva L3 puffstage 3-6    4807 larva L3 puffstage 7-9    4264 white prepupae new    4524 white prepupae 12hr    2910 white prepupae 24hr    4037 pupae 2d postWPP    4539 pupae 3d postWPP    2865 pupae 4d postWPP    3429 adult male 01day    4131 adult male 05day    4843 adult male 30day    6314 adult female 01day    7263 adult female 05day    5696 adult female 30day    6747 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010391    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010391 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval hindgut, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, adult ovary, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010391 expression level Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut    525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland    2696.1 Larval Trachea    786.275 Larval Carcass    697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut    560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body    578.2 Adult Salivary Gland    2687.6 Adult Heart    375.725 Adult VirginFemale Spermatheca    696.9 Adult InseminatedFemale Spermatheca    931 Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland    2013.6 Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut  525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland  (2696.1) Larval Trachea  (786.275) Larval Carcass  (697.55) Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut  (560) Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body  (578.2) Adult Salivary Gland  (2687.6) Adult Heart    375.725 Adult VirginFemale Spermatheca  (696.9) Adult InseminatedFemale Spermatheca  (931) Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland  (2013.6) Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut    525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland  (2696.1) Larval Trachea    786.275 Larval Carcass    697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut    560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body    578.2 Adult Salivary Gland  (2687.6) Adult Heart    375.725 Adult VirginFemale Spermatheca    696.9 Adult InseminatedFemale Spermatheca    931 Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland  (2013.6) Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut    525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland    2696.1 Larval Trachea    786.275 Larval Carcass    697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut    560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body    578.2 Adult Salivary Gland    2687.6 Adult Heart    375.725 Adult VirginFemale Spermatheca    696.9 Adult InseminatedFemale Spermatheca    931 Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland    2013.6 Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010391 expression level Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut    525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland    2696.1 Larval Trachea    786.275 Larval Carcass    697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut    560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body    578.2 Adult Salivary Gland    2687.6 Adult Heart    375.725 Adult VirginFemale Spermatheca    696.9 Adult InseminatedFemale Spermatheca    931 Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland    2013.6 Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut  525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland  (2696.1) Larval Trachea  786.275 Larval Carcass  697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut  560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body  578.2 Adult Salivary Gland  (2687.6) Adult Heart    375.725 Adult VirginFemale Spermatheca  696.9 Adult InseminatedFemale Spermatheca  (931) Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland  (2013.6) Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut    525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland  (2696.1) Larval Trachea    786.275 Larval Carcass    697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut    560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body    578.2 Adult Salivary Gland  (2687.6) Adult Heart    375.725 Adult VirginFemale Spermatheca    696.9 Adult InseminatedFemale Spermatheca    931 Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland  (2013.6) Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    338.5 Larval Midgut    469.4 Larval Hindgut    525.5 Larval Malpighian Tubules    337.4 Larval Fat Body    412.4 Larval Salivary Gland    2696.1 Larval Trachea    786.275 Larval Carcass    697.55 Adult Head    344.9 Adult Eye    278.85 Adult Brain    258.8 Adult Thoracic-Abdominal Ganglion    338.4 Adult Crop    464.8 Adult Midgut    560 Adult Hindgut    402.7 Adult Malpighian Tubules    293.4 Adult Fat Body    578.2 Adult Salivary Gland    2687.6 Adult Heart    375.725 Adult VirginFemale Spermatheca    696.9 Adult InseminatedFemale Spermatheca    931 Adult Ovary    434.8 Adult Testis    115.7 Adult Male Accessory Gland    2013.6 Adult Carcass    455 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    344.9   NA  Eye    278.85   NA  Brain    258.8   338.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    338.4   NA  Crop    464.8   469.4  Midgut    560   525.5  Hindgut    402.7   337.4  Malpighian Tubules    293.4   412.4  Fat Body    578.2   2696.1  Salivary Gland    2687.6   NA  Heart    375.725   786.275  Trachea    NA   NA  VirginFemale Spermatheca    696.9   NA  InseminatedFemale Spermatheca    931   NA  Ovary    434.8   NA  Testis    115.7   NA  Male Accessory Gland    2013.6   697.55  Carcass    455 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2522-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gtp-bp Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Gtp-bpGD6482 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Gtp-bp Class Mutagen Stocks Known lesion Gtp-bpG951 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gtp-bp Class Mutagen Stocks Known lesion Gtp-bpGD6482 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Gtp-bp-lacZ.CrebAmut} No P{Gtp-bp-lacZ} No UAS construct P{GD6482} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Gtp-bpG951 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axonogenesis inferred from expression pattern (assigned by UniProtKB) (Fredieu and Mahowald, 1993) regulation of protein secretion inferred from expression pattern (assigned by UniProtKB) (Fredieu and Mahowald, 1993)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane inferred from direct assay (assigned by UniProtKB) (Fredieu and Mahowald, 1993) lipid particle inferred from direct assay (Cermelli et al., 2006)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR007222 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR000897, InterPro:IPR007222, InterPro:IPR013822 (FlyBase Curators et al., 2004-) non-traceable author statement (Fredieu, 1993.12.20) mRNA binding non-traceable author statement (assigned by UniProtKB) (Fredieu and Mahowald, 1993) signal recognition particle binding inferred from sequence or structural similarity with NCBI_gi:4507223 (FlyBase, 1992-)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR007222 (FlyBase Curators et al., 2004-) SRP-dependent cotranslational protein targeting to membrane inferred from electronic annotation with InterPro:IPR000897, InterPro:IPR013822 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
signal recognition particle receptor complex inferred from sequence or structural similarity with NCBI_gi:4507223 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gtp-bp allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70718 DroID - A comprehensive database of gene and protein interactions. • FBgn0010391 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47251
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20395 Dere\GG18880 Dgri\GH24806 Dmoj\GI21534 Dper\GL27063 Dpse\GA15385 Dvir\GJ16008 Dwil\GK16226 Dyak\Gtp-bp
Curated drosophilid orthologs	Dpse\GA15385   Dyak\Gtp-bp
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005856-PA Aedes aegypti (mosquito) AGAP010894-PA Anopheles gambiae (mosquito) XP_395013.2 Apis mellifera (honey bee) XP_001947029.1 Acyrthosiphon pisum (pea aphid) At4g30600.1 Arabidopsis thaliana (wall cress) 14566 Batrachochytrium dendrobatidis (chytrid fungus) 202369 Branchiostoma floridae (lancelet) XP_001895235.1 Brugia malayi (roundworm nematode) BGIBMGA008392-PA Bombyx mori (silk worm) ENSBTAP00000018762 Bos taurus (bovine) CAL0003010 Candida albicans (a form of yeast) CN24398 Caenorhabditis brenneri (small nematode) CBP30009 Caenorhabditis briggsae (nematode) CE41537 Caenorhabditis elegans (worm) ENSCAFP00000015389 Canis familiaris (dog) CAGL0H01265g Candida glabrata (haploid yeast) Chro.80600 Cryptosporidium hominis (obligate parasite) ENSCINP00000024956 Ciona intestinalis (sea squirt) JA13665 Caenorhabditis japonica (nematode) CME016C Cyanidioschyzon merolae (red alga) cn03422 Cryptococcus neoformans (yeast-like fungus) cgd8_5260 Cryptosporidium parvum (protozoan parasite) CPIJ005421 Culex pipens (mosquito) ENSCPOP00000013498 Cavia porcellus (guinea pig) 100913 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000009534 Ciona savignyi (sedentary tunicate) 155737 Capitella spl (polychaete worm) DDB0252680 Dictyostelium discoideum (amoeba) DEHA2G20196g Debaryomyces Hansenii (yeast) 300824 Daphnia pulex (daphnia) ENSDARP00000081257 Danio rerio (zebra fish) ENSECAP00000012625 Equus caballus (horse) XP_652685 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008663 Gymnopilus aculeatus (mushroom) ENSGALP00000001577 Gallus gallus (chicken) GL50803_14856 Giardia lamblia (flagellated protozoan) 79619 Hypsipyla robusta (cedar shoot borer) ENSP00000328023 Homo sapiens (human) KLLA0C10714g Kluyveromyces lactis (yeast) 133609 Lottia gigantea (owl limpet) LmjF36.3570 Leishmania major (virus) 20343 Monocosta brevicollis (choanoflagellate) ENSMODP00000005641 Monodelphis domestica (gray opossum) ENSMMUP00000036595 Macaca mulatta (rhesus monkey) ENSMUSP00000034541 Mus musculus (house mouse) 90575 Nematostella vectensis (starlet anemone) XP_001599499.1 Nasonia vitripennis (wasp) ENSORLP00000018397 Oryzias latipes (japanese killifish) LOC_Os08g37444.1 Oryza sativa (asian rice) 15647 Ostreococcus tauri (green alga) PF13_0350 Plasmodium falciparum (protozoal parasite) PHUM001455-PA Pediculus humanus (human body louse) PP16071 Pristionchus pacificus (nematode) 95896 Physcomitrella patens (moss) ENSPPYP00000004624 Pongo pygmaeus (orangutan) 51228 Phytophthora ramorum (sudden oak death pathogen) 116388 Phytophthora sojae (root rot pathogen) 561342 Populus trichocarpa (black cottonwood) ENSPTRP00000047565 Pan troglodytes (chimpanzee) PVX_115290 Plasmodium vivax (protozoal parasite) ENSRNOP00000015177 Rattus norvegicus (norway rat) 4746330 Sorghum bicolor (sorghum) YDR292C Saccharomyces cerevisiae (budding yeast) Smp_095910.1 Schistosoma mansoni (trematode parasite) SPBC3B9.03 Schizosaccharomyces pombe (fission yeast) XP_001188635.1 Strongylocentrotus purpuratus (purple sea urchin) 33282 Trichoplax adhaerens (metazoa) TA13100 Theileria annulata (apicomplexan parasite) XP_001807129.1 Tribolium castaneum (red flour beetle) Tc00.1047053506337.210 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013220 Tetraodon nigroviridis (green spotted pufferfish) TP02_0423 Theileria parva (parasitic protozoan) 264070 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016827 Takifugu rubripes (pufferfish Takifugu) 14.m00409 Tetrahymena thermophila (ciliate protozoa) 90756.m00164 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008508 Xenopus tropicalis (frog) YALI0F23375g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13539 NV18078 LH13160 ISCW015342 ISCW007119 FBgn0068149 FBgn0218228 FBgn0203193 FBgn0166210 JGI_V11_300824 FBgn0075404 FBgn0164644 FBgn0144264 FBgn0132261 FBgn0111087 FBgn0097402 CPIJ005421 BGIBMGA008392 ACYPI009644 GB13324 AGAP010894 AAEL005856 PHUM229330 GLEAN_07993
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	33551 w* P{EP}Gtp-bpG951/FM7h
VDRC	v14877 w1118; P{GD6482}v14877/TM3
Genomic Clones ( 1 )
	BACR26J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25651
Other clones	FI05231 yak-em_Gtp
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03134 AT17847 GH05348 GH07537 GH14584 GH20583 GH26039 GM02928 GM05637 GM08590 GM22688 GM27512 LD09282 LD22968 LD38411 LD46381 LD47961 LP05736 LP07483 LP08685 LP11244 LP18860 LP19848 RE02178 RE09125 RE16671 RE30784 RE32973 RE36374 RE39209 RE42391 RE57115 RE60876 RH67964 SD06803 SD14101 SD14530 SD15096 SD21901 SD22019 SD22324 SD25511 UT01357 UT01804
Other clones	20994 37214 37278 CK01.43D.E8 CK01.45A.B7 CK01.60A.E10 CK00309 Dmel_dig_003029_0635_1415 EC053442 EC053923 EC053948 EC053949 EC054398 EC054960 EK015716 EK037052 EP00906 RC0-DA0008-130700-011-G07 RC0-DA0008-130700-012-E01 RC0-DA0008-130700-013-B05 RC0-DA0008-130700-013-B12
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47251
Antibody Information
	monoclonal (Fredieu and Mahowald, 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gtp-bp BEST:CK00309 (FlyBase, 1996-) Source for merge of: Gtp-bp CG2522 (Bayraktaroglu, 2000.4.7)
Additional comments	Source for merge of Gtp-bp BEST:CK00309 was sequence comparison (date:030820). (FlyBase, 1996-)
Other Comments
	Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080148 RefSeq (Proteins) • NP_524887 DDBJ / EMBL / GenBank • AA142160 AA142161 AA941487 AAB27926 AAF48002 AAL28877 AW942807 AY061329 S65640 Entrez Gene - A searchable database of RefSeq genes. • 47251 UniProtKB/Swiss-Prot • Q9U5L1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Signal recognition particle, SRP54 subunit, GTPase (IPR000897) ATPase, AAA+ type, core (IPR003593) Signal recognition particle, SRP54 subunit, helical bundle (IPR013822) Signal recognition particle receptor, alpha subunit, N-terminal (IPR007222) Longin-like (IPR011012)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70718 DroID - A comprehensive database of gene and protein interactions. • FBgn0010391 DRSC - Results from RNAi screens. • FBgn0010391 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2522-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47251 InParanoid A subset of ortholog calls from InParanoid. • AAEL005856-PA Aedes aegypti (mosquito) AGAP010894-PA Anopheles gambiae (mosquito) XP_395013.2 Apis mellifera (honey bee) XP_001947029.1 Acyrthosiphon pisum (pea aphid) At4g30600.1 Arabidopsis thaliana (wall cress) 14566 Batrachochytrium dendrobatidis (chytrid fungus) 202369 Branchiostoma floridae (lancelet) XP_001895235.1 Brugia malayi (roundworm nematode) BGIBMGA008392-PA Bombyx mori (silk worm) ENSBTAP00000018762 Bos taurus (bovine) CAL0003010 Candida albicans (a form of yeast) CN24398 Caenorhabditis brenneri (small nematode) CBP30009 Caenorhabditis briggsae (nematode) CE41537 Caenorhabditis elegans (worm) ENSCAFP00000015389 Canis familiaris (dog) CAGL0H01265g Candida glabrata (haploid yeast) Chro.80600 Cryptosporidium hominis (obligate parasite) ENSCINP00000024956 Ciona intestinalis (sea squirt) JA13665 Caenorhabditis japonica (nematode) CME016C Cyanidioschyzon merolae (red alga) cn03422 Cryptococcus neoformans (yeast-like fungus) cgd8_5260 Cryptosporidium parvum (protozoan parasite) CPIJ005421 Culex pipens (mosquito) ENSCPOP00000013498 Cavia porcellus (guinea pig) 100913 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000009534 Ciona savignyi (sedentary tunicate) 155737 Capitella spl (polychaete worm) DDB0252680 Dictyostelium discoideum (amoeba) DEHA2G20196g Debaryomyces Hansenii (yeast) 300824 Daphnia pulex (daphnia) ENSDARP00000081257 Danio rerio (zebra fish) ENSECAP00000012625 Equus caballus (horse) XP_652685 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008663 Gymnopilus aculeatus (mushroom) ENSGALP00000001577 Gallus gallus (chicken) GL50803_14856 Giardia lamblia (flagellated protozoan) 79619 Hypsipyla robusta (cedar shoot borer) ENSP00000328023 Homo sapiens (human) KLLA0C10714g Kluyveromyces lactis (yeast) 133609 Lottia gigantea (owl limpet) LmjF36.3570 Leishmania major (virus) 20343 Monocosta brevicollis (choanoflagellate) ENSMODP00000005641 Monodelphis domestica (gray opossum) ENSMMUP00000036595 Macaca mulatta (rhesus monkey) ENSMUSP00000034541 Mus musculus (house mouse) 90575 Nematostella vectensis (starlet anemone) XP_001599499.1 Nasonia vitripennis (wasp) ENSORLP00000018397 Oryzias latipes (japanese killifish) LOC_Os08g37444.1 Oryza sativa (asian rice) 15647 Ostreococcus tauri (green alga) PF13_0350 Plasmodium falciparum (protozoal parasite) PHUM001455-PA Pediculus humanus (human body louse) PP16071 Pristionchus pacificus (nematode) 95896 Physcomitrella patens (moss) ENSPPYP00000004624 Pongo pygmaeus (orangutan) 51228 Phytophthora ramorum (sudden oak death pathogen) 116388 Phytophthora sojae (root rot pathogen) 561342 Populus trichocarpa (black cottonwood) ENSPTRP00000047565 Pan troglodytes (chimpanzee) PVX_115290 Plasmodium vivax (protozoal parasite) ENSRNOP00000015177 Rattus norvegicus (norway rat) 4746330 Sorghum bicolor (sorghum) YDR292C Saccharomyces cerevisiae (budding yeast) Smp_095910.1 Schistosoma mansoni (trematode parasite) SPBC3B9.03 Schizosaccharomyces pombe (fission yeast) XP_001188635.1 Strongylocentrotus purpuratus (purple sea urchin) 33282 Trichoplax adhaerens (metazoa) TA13100 Theileria annulata (apicomplexan parasite) XP_001807129.1 Tribolium castaneum (red flour beetle) Tc00.1047053506337.210 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013220 Tetraodon nigroviridis (green spotted pufferfish) TP02_0423 Theileria parva (parasitic protozoan) 264070 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016827 Takifugu rubripes (pufferfish Takifugu) 14.m00409 Tetrahymena thermophila (ciliate protozoa) 90756.m00164 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008508 Xenopus tropicalis (frog) YALI0F23375g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47251 modMine - Data generated by the modENCODE project. • FBgn0010391 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13539 NV18078 LH13160 ISCW015342 ISCW007119 FBgn0068149 FBgn0218228 FBgn0203193 FBgn0166210 JGI_V11_300824 FBgn0075404 FBgn0164644 FBgn0144264 FBgn0132261 FBgn0111087 FBgn0097402 CPIJ005421 BGIBMGA008392 ACYPI009644 GB13324 AGAP010894 AAEL005856 PHUM229330 GLEAN_07993 REDfly - A database of transcriptional regulatory elements. • FBgn0010391
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BEST:CK00309   CG2522 (Abrams and Andrew, 2005, Cermelli et al., 2006, Seinen et al., 2010, Cammarato et al., 2011) CK00309 (Kopczynski et al., 1998) Gtp-bp (Ranade et al., 2008, Babenko et al., 2009, Moussian et al., 2005, Avet-Rochex et al., 2010) GTP-bp (Cermelli et al., 2006) mAb 13D5 (Fredieu and Mahowald, 1993) SrpRα (Abrams and Andrew, 2005, Fox et al., 2010)
Name Synonym	GTP-binding protein (Fredieu, 1993.12.20, Cammarato et al., 2011) GTP binding protein (Cermelli et al., 2006)
Secondary FlyBase IDs
	FBgn0025711 FBgn0030267
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Avet-Rochex et al., 2010, BMC Dev. Biol. 10: 65 An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. [FBrf0211137] Fox et al., 2010, J. Cell Biol. 191(3): 479--492 The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. [FBrf0212217] Seinen et al., 2010, PLoS ONE 5(10): e13119 RNAi Experiments in D. melanogaster: Solutions to the Overlooked Problem of Off-Targets Shared by Independent dsRNAs. [FBrf0212057] Show all research papers ...