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Gene Dmel\Nmdar1

General Information
Symbol	Dmel\Nmdar1	Species	D. melanogaster
Name	NMDA receptor 1	Annotation symbol	CG2902
Feature type	protein_coding_gene	FlyBase ID	FBgn0010399
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	dNR1, dnmdar-I, NR1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83A6-83A7	Sequence location	3R:1,334,564..1,349,050 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene NMDA receptor 1 is referred to in FlyBase by the symbol Dmel\Nmdar1 (CG2902, FBgn0010399). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: N-methyl-D-aspartate selective glutamate receptor activity. There is experimental evidence that it is involved in the biological process: olfactory learning; phototaxis; sensory perception of touch; associative learning; ionotropic glutamate receptor signaling pathway; long-term memory; medium-term memory; imaginal disc-derived wing morphogenesis. 20 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Calmodulin-binding domain C0, NMDA receptor, NR1 subunit; Extracellular ligand-binding receptor; Extracellular solute-binding protein, family 3; Glutamate receptor, L-glutamate/glycine-binding; Ionotropic glutamate receptor; NMDA receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1641697_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nmdar1. Gene sequence location is 3R:1334564..1349050.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms sensory perception of touch ionotropic glutamate receptor signaling pathway integral to membrane ionotropic glutamate receptor complex
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A6-83A7   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83A-83B     (Schmitt, 1993.5.5) 83A-83B   (determined by in situ hybridisation)   (Ultsch et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nmdar1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nmdar1-RA FBtr0078763  NM_169059   4170   997
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nmdar1-PA   FBpp0078410   112.3   997   8.07     NP_730940   AAF52016
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	Staining pattern of Nmdar1 is determined using an antisera raised against the mammalian ionotropic NMDA1 receptor. Authors suggest lack of appreciable staining pattern in the optic lobes may reflect species differences. sr101111 (Kolodziejczyk et al., 2008)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Calmodulin-binding domain C0, NMDA receptor, NR1 subunit (IPR018882) Ionotropic glutamate receptor (IPR001320) NMDA receptor (IPR001508) Extracellular ligand-binding receptor (IPR001828) Extracellular solute-binding protein, family 3 (IPR001638) Glutamate receptor, L-glutamate/glycine-binding (IPR019594)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF52016   AQ072982   AY070577 AAL48048   BI170589   BI212322   BI227523   CO188045   CO269343   CO294341   CO308357   CO328415   CO339770   EC063976   EC071165   EC203749   EC224241   EC229637   EC246512   EC252765   EC256647   X71790 CAA50675
UniProtKB/Swiss-Prot	Q24418
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 16   embryonic/larval central nervous system | ubiquitous   (Volkner et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   lobe system of mushroom body   (Kolodziejczyk et al., 2008) adult brain | punctate & ubiquitous   (Xia et al., 2005) neuron | subset of adult brain   (Chen et al., 2012) dorsal anterior lateral neuron of the protocerebrum   (Chen et al., 2012) adult brain | faint & ubiquitous   (Wu et al., 2007) ellipsoid body | faint & ubiquitous   (Wu et al., 2007) calyx of adult mushroom body   (Wu et al., 2007)
Additional Descriptive Data
	Nmdar1 protein is expressed throughout the adult brain but more strongly in some cells. Staining is punctate which suggests synaptic localisation. Cells more strongly stained include several pairs of dorsal posterior medial (DPM2, 3 pairs of DPM3, 4 pairs of DPM4 and DPM5) neurons that surround the mushroom body calyx, in the dorsal anterior lateral neuron of the protocerebrum (DAL), in the dorsal posterior lateral (DPL) neurons in the lateral protocerebrum, the ventral anterior lateral (VAL) neurons in the anterior protocerebrum and two pairs of ventral posterior neurons in the posterior protocerebrum. There is restricted expression in the optic lobe. (Xia et al., 2005)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
integral to membrane inferred from direct assay (Xia et al., 2005) ionotropic glutamate receptor complex inferred from physical interaction with Nmdar2 (Xia et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    192.4 Larval Midgut    2.2 Larval Hindgut    2 Larval Malpighian Tubules    4.3 Larval Fat Body    5.2 Larval Salivary Gland    4.8 Larval Trachea    0.775 Larval Carcass    3.5 Adult Head    67.3 Adult Eye    12.175 Adult Brain    330.1 Adult Thoracic-Abdominal Ganglion    319 Adult Crop    4 Adult Midgut    0.4 Adult Hindgut    3.9 Adult Malpighian Tubules    4.8 Adult Fat Body    7.4 Adult Salivary Gland    3.5 Adult Heart    0.525 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    6.4 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    67.3   NA  Eye    12.175   NA  Brain    330.1   192.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    319   NA  Crop    4   2.2  Midgut    0.4   2  Hindgut    3.9   4.3  Malpighian Tubules    4.8   5.2  Fat Body    7.4   4.8  Salivary Gland    3.5   NA  Heart    0.525   0.775  Trachea    NA   NA  VirginFemale Spermatheca    8.7   NA  InseminatedFemale Spermatheca    5.7   NA  Ovary    0.9   NA  Testis    2   NA  Male Accessory Gland    6.4   3.5  Carcass    4.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    25 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    18 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    17 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	BDGP expression data • RE12105 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010399 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2902-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Nmdar1 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | recessive Nmdar1F viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW Nmdar1GD2808 Nmdar1KK107519 viable, with Scer\GAL4pnr-MD237 Nmdar1GD2808 viable | recessive, with Scer\GAL4[-]: Nmdar1EP331 Nmdar1EP3511 Other Phenotypes Allele learning defective | heat sensitive, with Scer\GAL4P26.hs Nmdar1EP331 learning defective | recessive, with Scer\GAL4[-]: Nmdar1EP331 Nmdar1EP3511 mating defective | dominant Nmdar1F memory defective Nmdar1EP331 Nmdar1EP3511 memory defective, with Scer\GAL4ey-OK107 Nmdar1dsRNA.Scer\UAS.cWa memory defective, with Scer\GAL4Feb170 Nmdar1dsRNA.Scer\UAS.cWa memory defective | heat sensitive, with Scer\GAL4hs.PU Nmdar1dsRNA.Scer\UAS.cWa memory defective | heat sensitive, with Scer\GAL4P26.hs Nmdar1EP331 neuroanatomy defective | larval stage, with Dcr-2Scer\UAS.cDa, Scer\GAL41003.3 Nmdar1GD2808 phototaxis defective, with Scer\GAL4elav-C155 Nmdar1Scer\UAS.Exel phototaxis defective, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B Nmdar1Scer\UAS.Exel phototaxis defective | heat sensitive, with Scer\GAL4hs.PB Nmdar1EP331 Nmdar1Scer\UAS.Exel touch sensitivity defective, with Scer\GAL4109(2)80 Nmdar1KK107519 touch sensitivity defective, with Scer\GAL41003.3 Nmdar1KK107519 touch sensitivity defective | larval stage, with Dcr-2Scer\UAS.cDa, Scer\GAL41003.3 Nmdar1GD2808 Phenotype manifest in Allele dorsal multidendritic neuron ddaA | larval stage, with Dcr-2Scer\UAS.cDa, Scer\GAL41003.3 Nmdar1GD2808 sensory dendrite | larval stage, with Dcr-2Scer\UAS.cDa, Scer\GAL41003.3 Nmdar1GD2808
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Nmdar1 Class Mutagen Stocks Known lesion Nmdar105616 P-element activity 1 Yes Nmdar1EP331 hypomorphic allele - genetic evidence P-element activity 1 Yes Nmdar1DG23512 P-element activity 0 -- Nmdar1EP3511 hypomorphic allele - genetic evidence P-element activity 0 Yes Nmdar1F 0 Yes Nmdar1MI01796 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nmdar1 Class Mutagen Stocks Known lesion Nmdar1lurcher.GMR in vitro construct - amino acid replacement 3 Yes Nmdar1GD2808 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nmdar1GMR.Exel in vitro construct - regulatory fusion 2 Yes Nmdar1lurcher.Scer\UAS in vitro construct - amino acid replacement 2 Yes Nmdar1Scer\UAS.Exel in vitro construct - regulatory fusion 2 Yes Nmdar1HMS02199 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nmdar1HMS02200 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nmdar1JF01961 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nmdar1KK107519 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nmdar1+tCosmidB in vitro construct - genomic fragment 0 Yes Nmdar1+tCosmidC in vitro construct - genomic fragment 0 Yes Nmdar1dsRNA.Scer\UAS.cWa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Nmdar1Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Nmdar1tCosmidA in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6144 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2808} NA P{KK107519} NA P{TRiP.HMS02199} NA P{TRiP.HMS02200} NA P{TRiP.JF01961} NA P{UAS-Nmdar1.dsRNA} NA P{UAS-Nmdar1.Exel} NA P{UAS-Nmdar1.lurcher} NA P{UAS-Nmdar1.M} NA characterization construct P{83A.A} NA P{83A.B} NA P{83A.C} NA P{GMR-Nmdar1.Exel} NA P{GMR-Nmdar1.lurcher} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Itp-r83A05616 No insertion of mobile activating element P{EP}Nmdar1EP331 NA P{EP}Nmdar1EP3511 NA P{XP}Itp-r83Ad01974 NA miscellaneous insertions F{}Nmdar1F NA Mi{MIC}Itp-r83AMI01796 NA P{GT1}BG00386BG00386 NA P{wHy}Nmdar1DG23512 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
contributes_to N-methyl-D-aspartate selective glutamate receptor activity inferred from direct assay (Xia et al., 2005)
Biological Process
CV term Evidence References
associative learning inferred from direct assay (Qin and Dubnau, 2010) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) ionotropic glutamate receptor signaling pathway inferred from direct assay (Xia et al., 2005) long-term memory inferred from genetic interaction with Nmdar2 (Chen et al., 2012) inferred from mutant phenotype (Xia et al., 2005, Wu et al., 2007) medium-term memory inferred from mutant phenotype (Wu et al., 2007) olfactory learning inferred from genetic interaction with PQBP1 (Tamura et al., 2010) inferred from mutant phenotype (Xia et al., 2005) phototaxis inferred from direct assay (Zhou et al., 2010) sensory perception of touch inferred from mutant phenotype (Tsubouchi et al., 2012)
Cellular Component
CV term Evidence References
integral to membrane inferred from direct assay (Xia et al., 2005) ionotropic glutamate receptor complex inferred from physical interaction with Nmdar2 (Xia et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
extracellular-glutamate-gated ion channel activity inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR001508, InterPro:IPR019594 (FlyBase Curators et al., 2004-) N-methyl-D-aspartate selective glutamate receptor activity inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) inferred from sequence or structural similarity with NCBI_gi:4504123 (FlyBase, 1992-) non-traceable author statement (Schmitt, 1993.5.5)
Biological Process
CV term Evidence References
ion transport inferred from electronic annotation with InterPro:IPR001508 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
outer membrane-bounded periplasmic space inferred from electronic annotation with InterPro:IPR001638 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Nmdar1 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG13220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG2023 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG2051 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG2070 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG3008 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG3164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG4858 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - CaBP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Dic1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Droj2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - LanB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Mcr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Nup44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Pngl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - RPA2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rab11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Ranbp9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - RhoL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpn3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Sec61α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Spt-I anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Src64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - Ugt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - abs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - bor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - levy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - mod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nmdar1 - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nmdar1 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010399 DroID - A comprehensive database of gene and protein interactions. • FBgn0010399 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40665
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG680JG2 Dipteran inclusive ortholog search EOG65MNDB Insect inclusive ortholog search EOG61VHXT Arthropod inclusive ortholog search EOG6G1JXB Metazoa inclusive ortholog search EOG6DC66D
Orthologs in Drosophila Species (EOG680JG2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Nmdar1     Drosophila simulans   Dsim\GD19612 Y   Drosophila sechellia   Dsec\GM10627 Y   Drosophila erecta   Dere\GG10981 Y   Drosophila yakuba   Dyak\GE25274 Y   Drosophila ananassae   Dana\GF17704 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15505 Y   Drosophila persimilis   Dper\GL22160 Y   Drosophila willistoni   Dwil\GK23704 Y   Drosophila virilis   Dvir\GJ24560 Y   Drosophila mojavensis   Dmoj\GI24494 Y   Drosophila grimshawi   Dgri\GH18993 Y
Orthologs in non-Drosophila Dipterans (EOG65MNDB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008587   Anopheles gambiae Malaria mosquito  Agam\AGAP001478   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017065
Orthologs in non-Dipteran Insects (EOG61VHXT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46886   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG026254   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037333   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019393   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15283   Atta cephalotes Leafcutter ant  Acep\ACEP16594   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19511   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21707   Linepithema humile Argentine ant  Lhum\LH10392   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12653   Solenopsis invicta Red fire ant  Sinv\SINV21584   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001813   Bombyx mori Silkmoth  Bmor\BGIBMGA010135   Pediculus humanus Human body louse  Phum\PHUM105890   Tribolium castaneum Red flour beetle  Tcas\TC011848
Orthologs in non-Insect Arthropods (EOG6G1JXB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_255143   Ixodes scapularis Deer tick  Isca\ISCW010976   Ixodes scapularis Deer tick  Isca\ISCW005487
Orthologs in non-Arthropod Metazoa (EOG6DC66D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\nmr-1   Danio rerio Zebrafish  Drer\grin1b   Danio rerio Zebrafish  Drer\grin1a   Xenopus tropicalis Western clawed frog  Xtro\grin1   Gallus gallus Domestic chicken  Ggal\GRIN1   Mus musculus House mouse  Mmus\Grin1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011726   Homo sapiens Human  Hsap\GRIN1
Human Orthologs (1)
Gene OMIM HGNC Hsap\GRIN1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19612 Drosophila sechellia Dsec\GM10627 Drosophila erecta Dere\GG10981 Drosophila yakuba Dyak\GE25274 Drosophila ananassae Dana\GF17704 Drosophila pseudoobscura pseudoobscura Dpse\GA15505 Drosophila persimilis Dper\GL22160 Drosophila willistoni Dwil\GK23704 Drosophila virilis Dvir\GJ24560 Drosophila mojavensis Dmoj\GI24494 Drosophila grimshawi Dgri\GH18993
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	17112 w1118; P{EP}Nmdar1EP331 25941 y1 v1; P{TRiP.JF01961}attP2 8274 P{UAS-Nmdar1.Exel}1, y1 w1118 8275 y1 w1118; P{UAS-Nmdar1.Exel}2 8279 y1 w1118; P{GMR-Nmdar1.Exel}3 8272 y1 w1118; P{UAS-Nmdar1.lurcher}2 8273 y1 w1118; P{UAS-Nmdar1.lurcher}3 8276 y1 w1118; P{GMR-Nmdar1.lurcher}3 8277 P{GMR-Nmdar1.lurcher}1, y1 w1118
VDRC	v104773 P{KK107519}VIE-260B v37333 w1118; P{GD2808}v37333 v37334 w1118; P{GD2808}v37334
	More stocks available...
Genomic Clones ( 2 )
	BACR24O24 BACR34M23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE12105
Other clones	DPiM_RE12105
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE17391 RE24595
Other clones	63021 73561 76642 153872 214413.62 214569.51 CK01.43A.B8 CK01.122C.G4 EK036640 EK094158 EK206615 EK257716 EP09154 EP09360
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010399 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40665
Antibody Information
	polyclonal (Xia et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nmdar CG2902 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Nmdar1 cDNA is isolated and sequence analysis displays a high sequence identity to the vertebrate NMDAR1 receptor subunit. Nmdar1 transcripts are abundant in adult heads. (Ultsch et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169059 RefSeq (Proteins) • NP_730940 DDBJ / EMBL / GenBank • AAF52016 AAL48048 AQ072982 AY070577 BI170589 CAA50675 X71790 Entrez Gene - A searchable database of RefSeq genes. • 40665 UniProtKB/Swiss-Prot • Q24418
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Calmodulin-binding domain C0, NMDA receptor, NR1 subunit (IPR018882) Ionotropic glutamate receptor (IPR001320) NMDA receptor (IPR001508) Extracellular ligand-binding receptor (IPR001828) Extracellular solute-binding protein, family 3 (IPR001638) Glutamate receptor, L-glutamate/glycine-binding (IPR019594) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE12105
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010399 DroID - A comprehensive database of gene and protein interactions. • FBgn0010399 DRSC - Results from RNAi screens. • FBgn0010399 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010399 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2902-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010399 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40665 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/nmda1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40665 modMine - Data generated by the modENCODE project. • FBgn0010399
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	CG2902 (Mount, 2001.8.14, Lee et al., 2009, Perkins et al., 1.15.2009, Benton et al., 2009, Croset et al., 2010, Venkiteswaran and Hasan, 2009, Keleman et al., 2009.8.5, Tsubouchi et al., 2012, Ni et al., 2010.12.1) DmelNmdar1 (Croset et al., 2010) DMNMDAR1 (Wismar et al., 1997) DNmdar   dnmdar-I (Volkner et al., 2000) DNMDAR-I (Schmitt et al., 1993, Ultsch et al., 1993) dNR1 (Xia et al., 2005, Margulies et al., 2005, Glanzman, 2005, Xia et al., 2007, Chen et al., 2012, Tamura et al., 2010, Wu et al., 2007, Sinakevitch et al., 2010, Venkiteswaran and Hasan, 2009, Qin and Dubnau, 2010, Larkin et al., 2010) DrNR1 (Fu et al., 2001) NMDA (Draper et al., 2008) Nmdar (Mensch et al., 2008) Nmdar1 (Wu et al., 2007, Benton et al., 2009, Mensch et al., 2008, Singh et al., 2010, Tsubouchi et al., 2012, Croset et al., 2010, Tsubouchi et al., 2012, Carreira et al., 2011) NMDAR1 (Kolodziejczyk et al., 2008, Venkiteswaran and Hasan, 2009, Zhou et al., 2010) NMdar1 (Hoopfer et al., 2008) NMDA R1 (Draper et al., 2008) nmr (Schmitt, 1993.5.5) NR1 (French and Heberlein, 2009, Zachepilo et al., 2008) NRI (Littleton and Ganetzky, 2000)
Name Synonym	dNR1 (Xia et al., 2005) NMDAR (Dubnau et al., 2003) NMDA receptor (Rothenfluh and Heberlein, 2002, Dubnau et al., 2003) NMDA receptor 1 (Sambandan et al., 2006, Tsubouchi et al., 2012) NMDA receptor I (Fu et al., 2001)
Secondary FlyBase IDs
References ( 71 )
Generate a list of	All references relating to this gene ( 71 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 8 )
	Chen et al., 2012, Science 335(6069): 678--685 Visualizing long-term memory formation in two neurons of the Drosophila brain. [FBrf0217453] Sudhakaran et al., 2012, J. Neurosci. 32(21): 7225--7231 Plasticity of recurrent inhibition in the Drosophila antennal lobe. [FBrf0218409] Tsubouchi et al., 2012, Curr. Biol. 22(22): 2124--2134 Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae. [FBrf0219946] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Das et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(36): E646--E654 Plasticity of local GABAergic interneurons drives olfactory habituation. [FBrf0215244] Huang et al., 2011, Development 138(11): 2283--2291 DPP-mediated TGF{beta} signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase. [FBrf0213687] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...