FlyBase Gene Report: Dmel\Os-C

General Information

Symbol

Dmel\Os-C

Species

D. melanogaster

Name

Os-C

Annotation Symbol

CG3250

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010401

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

84E6-84E6

Sequence location

3R:7,978,959..7,979,614 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:7978959..7979614

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Os-C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q23971)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Os-C-RB

FBtr0300320

NM_001170072

604

153

Os-C-RC

FBtr0300321

NM_141496

550

135

Os-C-RD

FBtr0331341

NM_001275428

538

131

Additional Transcript Data and Comments

Reported size (kB)

0.78 (northern blot)

(McKenna et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Os-C-PB

FBpp0289548

16.8

153

4.12

FBpp0289549

14.9

135

4.12

FBpp0303759

14.5

131

4.16

A0A0B4KFT1

NP_001262357

AGB95739

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

118 (aa); 13.1 (kD)

(McKenna et al., 1994)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Os-C using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Os-C_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.66

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

sacculus

(McKenna et al., 1994)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

Johnston organ

(Senthilan et al., 2012)

third segment of antenna

(McKenna et al., 1994)

Additional Descriptive Data

Transcripts are detected in RNA from antennae but not in RNA from chemosensory depleted heads or bodies. In situ hybridization reveals a10 expression surrounding the sacculus and in patches elsewhere on the antenna.

(McKenna et al., 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Os-C in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Os-C

View exonic expression by tissue for Dmel\Os-C

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40942/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010401

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010401

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010401

Flygut - An atlas of the Drosophila adult midgut

FBgn0010401

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Os-C

Transgenic constructs containing regulatory region of Os-C

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6263

(Ryder, 2004.4.26)

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Os-C^GD15413

visible, with Scer\GAL4^pnr-MD237

Os-C^GD15413

Phenotype manifest in

Allele

mesonotum, with Scer\GAL4^pnr-MD237

Os-C^GD15413

trichogen cell, with Scer\GAL4^pnr-MD237

Os-C^GD15413

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Os-C. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66127

DroID - A comprehensive database of gene and protein interactions.

FBgn0010401

MIST (protein-protein) - An integrated Molecular Interaction Database

40942

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84E6-84E6

Sequence location

3R:7,978,959..7,979,614 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84E6-84E6

Limits computationally determined from genome sequence between P{EP}EP3060^EP3060 and P{PZ}grn⁰⁵⁹³⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

83C-83D

(McKenna, 1993.10.15)

84E-84E

(Hekmat-Scafe, 1995.1.5)

84E-84E

(determined by in situ hybridisation)

(McKenna et al., 1994)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

VDRC

v106394

P{KK111186}VIE-260B

v1851

w¹¹¹⁸; P{GD750}v1851

v33827

w¹¹¹⁸; P{GD15413}v33827

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP14506

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010401

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010401

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.

(McDonald and Rosbash, 2001)

"84E" was stated as revision.

(Hekmat-Scafe, 1995.1.5)

Isolated from a subtracted antennal cDNA library enriched for cDNAs expressed in the antennae but not the rest of the head or body of adult flies. Os-C maps near to but distinguishable from the location of the P-element insertion in Ecol\lacZ²²⁴⁶.

(McKenna et al., 1994)

An Os-C cDNA has been cloned and sequenced.

(McKenna et al., 1994)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Os-C CG3250

(Gong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG3250

(Keleman et al., 2009.8.5)

OS-C

(Lemos et al., 2008, McKenna et al., 1994, McKenna, 1993.10.15)

Os-C

(Huang et al., 2024, Gao et al., 2021, Immonen and Ritchie, 2012, Senthilan et al., 2012, Kong et al., 2010, Graze et al., 2007, Reiter et al., 2007)

Os-c

(McGraw et al., 2004)

Name Synonyms

Os-C

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40942

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

U02545

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q23971

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q23971

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q23971

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40942/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010401

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010401

FlyMine - An integrated database for Drosophila genomics

FBgn0010401

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3250

MARRVEL_MODEL - MARRVEL (model organism gene)

40942

Linkouts

BioGRID - A database of protein and genetic interactions.

66127

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010401

DroID - A comprehensive database of gene and protein interactions.

FBgn0010401

DRSC - Results frm RNAi screens

FBgn0010401

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Os-C_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010401

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010401

Flygut - An atlas of the Drosophila adult midgut

FBgn0010401

MIST (protein-protein) - An integrated Molecular Interaction Database

40942

References (31)

The following external sites may use different assemblies or annotations than FlyBase.

-0.66

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