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Gene Dmel\Obp83b

General Information
Symbol	Dmel\Obp83b	Species	D. melanogaster
Name	Odorant-binding protein 83b	Annotation symbol	CG11422
Feature type	protein_coding_gene	FlyBase ID	FBgn0010403
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	OS-E, Obp83b, 83b
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	83D1-83D1	Sequence location	3R:1,801,899..1,802,539 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Odorant-binding protein 83b is referred to in FlyBase by the symbol Dmel\Obp83b (CG11422, FBgn0010403). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: odorant binding. Based on sequence similarity, it is predicted to be involved in the biological process: sensory perception of chemical stimulus. 14 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Pheromone/general odorant binding protein; Pheromone/general odorant binding protein, PBP/GOBP, domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1638066_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Os-E. Gene sequence location is 3R:1801899..1802539.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83D1-83D1   Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83C-83D     (McKenna, 1993.10.14) 83C1-83D5     (Hekmat-Scafe, 1996.12.9) 83C-83D     (Hekmat-Scafe et al., 1995) 83C-83C   (determined by in situ hybridisation)   (Hekmatpanah et al., 1993) 83C-83D   (determined by in situ hybridisation)   (McKenna et al., 1994)
Experimentally Determined Recombination Data
Location	3- (Hekmat-Scafe et al., 1995)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Obp83b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Obp83b-RA FBtr0078655  NM_079518   528   141
Additional Transcript Data & Comments
Reported size (kB)	0.66 (northern blot) (McKenna et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Obp83b-PA   FBpp0078304   16.1   141   6.01     NP_524242   AAF51928
Additional Polypeptide Data & Comments
Reported size (kDa)	141 (aa); 16.1 (kD) (McKenna et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pheromone/general odorant binding protein (IPR006170) Pheromone/general odorant binding protein, PBP/GOBP, domain (IPR023316)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF51928   AJ574644 CAE00882   AJ574762 CAE00417   AJ574763 CAE00419   AJ574764 CAE00421   AJ574765 CAE00423   AJ574766 CAE00425   AJ574767 CAE00427   AJ574768 CAE00429   AJ574769 CAE00431   AJ574770 CAE00433   AJ574771 CAE00435   AJ574772 CAE00437   AJ574773 CAE00439   AJ574774 CAE00441   BT023392   BT126362   CO296188   CZ483449   EC224853   EL869661   EL869662   U02543 AAA21356   U81502 AAB51683
UniProtKB/Swiss-Prot	Q23970
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   sensillum trichodeum of antennal segment 3   (McKenna et al., 1994) in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   third segment of antenna   (McKenna et al., 1994)
Additional Descriptive Data
	Transcripts are detected in RNA from antennae but not in RNA from chemosensory depleted heads or bodies. In situ hybridization reveals that expression is limited to the ventro-lateral region of the third antennal segment, in a pattern consistent with the distribution of sensilla trichodea. In deeper sections, expression is observed beneath sensilla trichodea sensory hairs. (McKenna et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   antennal sensillum trichodeum T1   (Shanbhag et al., 2001) antennal sensillum trichodeum T2   (Shanbhag et al., 2001) antennal sensillum trichodeum T3   (Shanbhag et al., 2001) antennal intermediate sensillum I2   (Shanbhag et al., 2001) antennal intermediate sensillum I3   (Shanbhag et al., 2001) tormogen cell | subset   (Shanbhag et al., 2001) trichogen cell | subset   (Shanbhag et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head    3127.5 Adult Eye    608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head  (3127.5) Adult Eye  (608.25) Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head  (3127.5) Adult Eye    608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head    3127.5 Adult Eye    608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head    3127.5 Adult Eye    608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head  (3127.5) Adult Eye  608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head  (3127.5) Adult Eye    608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    8.2 Larval Hindgut    2 Larval Malpighian Tubules    3.1 Larval Fat Body    5.5 Larval Salivary Gland    6.1 Larval Trachea    8.825 Larval Carcass    4.625 Adult Head    3127.5 Adult Eye    608.25 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    5.5 Adult Midgut    2.7 Adult Hindgut    3.4 Adult Malpighian Tubules    1.8 Adult Fat Body    4.3 Adult Salivary Gland    12.1 Adult Heart    4.7 Adult VirginFemale Spermatheca    3.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    3.8 Adult Testis    6.8 Adult Male Accessory Gland    5.2 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3127.5   NA  Eye    608.25   NA  Brain    3.6   2.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.9   NA  Crop    5.5   8.2  Midgut    2.7   2  Hindgut    3.4   3.1  Malpighian Tubules    1.8   5.5  Fat Body    4.3   6.1  Salivary Gland    no informative data   NA  Heart    4.7   8.825  Trachea    NA   NA  VirginFemale Spermatheca    3.9   NA  InseminatedFemale Spermatheca    4.5   NA  Ovary    3.8   NA  Testis    6.8   NA  Male Accessory Gland    5.2   4.625  Carcass    1.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day    32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day  (32) adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day    32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day    32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day    32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day  32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day    32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    19 adult male 05day    19 adult male 30day    32 adult female 01day    3 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010403 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11422-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Obp83bf00970 viable, with Scer\GAL4pnr-MD237 Obp83bGD747 Sterility Allele fertile Obp83bf00970 Phenotype manifest in Allele
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Obp83b Class Mutagen Stocks Known lesion Obp83bf00970 piggyBac transposase 1 -- Obp83bM13 natural population 0 Yes Obp83bM20 natural population 0 Yes Obp83bM22 natural population 0 Yes Obp83bM23 natural population 0 Yes Obp83bM26 natural population 0 Yes Obp83bM36 natural population 0 Yes Obp83bM40 natural population 0 Yes Obp83bM47 natural population 0 Yes Obp83bM54 natural population 0 Yes Obp83bM66 natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Obp83b Class Mutagen Stocks Known lesion Obp83bGD747 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Obp83bKK111256 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Obp83bGD17313 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7284 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Obp83bf00970 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
odorant binding inferred from sequence alignment with UniProtKB:P34174 (Hekmat-Scafe et al., 2002) inferred from sequence or structural similarity with lush (Vieira and Rozas, 2011) pheromone binding non-traceable author statement (McKenna, 1993.10.14)
Biological Process
CV term Evidence References
sensory perception of chemical stimulus inferred from sequence alignment with UniProtKB:P34174 (Hekmat-Scafe et al., 2002) inferred from sequence or structural similarity with lush (Vieira and Rozas, 2011)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence model (Vieira and Rozas, 2011) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Obp83b allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0010403
Orthologs
OrthoDB Orthologs (20) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60K8KF Dipteran inclusive ortholog search EOG6ZKJWP Insect inclusive ortholog search EOG6GMSVB Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG60K8KF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Obp83b     Drosophila simulans   Dsim\Os-E Y   Drosophila sechellia   Dsec\Obp83b Y   Drosophila erecta   Dere\Os-E Y   Drosophila yakuba   Dyak\Obp83b Y   Drosophila ananassae   Dana\Obp83b Y   Drosophila pseudoobscura pseudoobscura   Dpse\Obp83b Y   Drosophila persimilis   Dper\Obp83b Y   Drosophila willistoni   Dwil\Obp83b Y
Orthologs in non-Drosophila Dipterans (EOG6ZKJWP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009449 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013018 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008013 Y Anopheles gambiae Malaria mosquito  Agam\OBP-3 Y Anopheles gambiae Malaria mosquito  Agam\OBP17 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007604 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007617 Y
Orthologs in non-Dipteran Insects (EOG6GMSVB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI31683 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI25887 Y Pediculus humanus Human body louse  Phum\PHUM486880 Y Tribolium castaneum Red flour beetle  Tcas\OBP07 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Os-E Drosophila sechellia Dsec\Obp83b Drosophila erecta Dere\Os-E Drosophila yakuba Dyak\Obp83b Drosophila ananassae Dana\Obp83b Drosophila pseudoobscura pseudoobscura Dpse\Obp83b Drosophila persimilis Dper\Obp83b Drosophila willistoni Dwil\Obp83b
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{WH}Obp83bf00970
VDRC	v102252 P{KK111256}VIE-260B v3405 w1118 P{GD747}v3405
Genomic Clones ( 1 )
	BACR18I07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01759
Other clones	IP01760
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EK213012 IP01757 IP01758
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010403 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40738
Antibody Information
	polyclonal (Shanbhag et al., 2001)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Obp83b Os-E (FlyBase, 2009-)
Source for database merge of
Additional comments	FlyBase Curator comment: 'Os-E' renamed to 'Obp83b' to rationalize the nomenclature of 'Odorant-binding protein'-encoding genes consistent with the recommendations in FBrf0151704 and FBrf0205523. (FlyBase, 2009-)
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) Os-E and Pbprp3 are located about 1kb apart and contain a similar exon-intron organisation. Expression of both proteins is restricted spatially to two distinct types of olfactory hairs located in the ventrolateral region of the antenna. Immunocytochemical EM studies reveal that all sensilla examined express both proteins, thus, an individual sensilla can contain more than one odorant-binding protein. (Hekmat-Scafe et al., 1997) Isolated from a subtracted antennal cDNA library enriched for cDNAs expressed in the antennae but not the rest of the head or body of adult flies. (McKenna et al., 1994) An Os-E cDNA has been cloned and sequenced. (McKenna et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079518 RefSeq (Proteins) • NP_524242 DDBJ / EMBL / GenBank • AAA21356 AAB51683 AAF51928 AJ574644 AJ574762 AJ574763 AJ574764 AJ574765 AJ574766 AJ574767 AJ574768 AJ574769 AJ574770 AJ574771 AJ574772 AJ574773 AJ574774 CAE00417 CAE00419 CAE00421 CAE00423 CAE00425 CAE00427 CAE00429 CAE00431 CAE00433 CAE00435 CAE00437 CAE00439 CAE00441 CAE00882 CZ483449 U02543 U81502 Entrez Gene - A searchable database of RefSeq genes. • 40738 UniProtKB/Swiss-Prot • Q23970
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pheromone/general odorant binding protein (IPR006170) Pheromone/general odorant binding protein, PBP/GOBP, domain (IPR023316)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0010403 DRSC - Results from RNAi screens. • FBgn0010403 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010403 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11422-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010403 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40738 modMine - Data generated by the modENCODE project. • FBgn0010403
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	83b (Graham and Davies, 2002, Smith, 2002.1.14, Galindo and Smith, 2001) CG11422 (Keleman et al., 2009.8.5) DmelObp83b (Vieira and Rozas, 2011) Obp83b (Sánchez-Gracia and Rozas, 2008, Hekmat-Scafe et al., 2002, Hekmat-Scafe, 2002.3.5, Vieira et al., 2007, Zhou et al., 2009, Shanbhag et al., 2001, ) obp83b (de Bruyne and Warr, 2006) OS-E (Sánchez-Gracia and Rozas, 2008, Sanchez-Gracia et al., 2003, Graham and Davies, 2002, Hekmat-Scafe et al., 2000, Yamamoto and Nakano, 1999, McKenna, 1993.10.14, Hekmat-Scafe, 1996.12.9, Hekmat-Scafe et al., 1999, Hekmat-Scafe et al., 1997, Hekmat-Scafe and Carlson, 1996, Hekmat-Scafe et al., 1995, McKenna et al., 1994, Sanchez-Gracia and Rozas, 2007, Kong et al., 2010) Os-E (Immonen and Ritchie, 2012, Zhou et al., 2009) PBP-H1 (Hekmatpanah et al., 1993)
Name Synonym	Odorant-binding protein 83b   Olfactory-specific E (Hekmat-Scafe et al., 1995, Tsuda et al., 2006) Pheromone-binding protein Homolog 1 (Hekmatpanah et al., 1993)
Secondary FlyBase IDs
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Immonen and Ritchie, 2012, Proc. Biol. Sci. 279(1732): 1359--1365 The genomic response to courtship song stimulation in female Drosophila melanogaster. [FBrf0217554] Vieira and Rozas, 2011, Genome Biol. Evol. 3: 476--490 Comparative Genomics of the Odorant-Binding and Chemosensory Protein Gene Families across the Arthropoda: Origin and Evolutionary History of the Chemosensory System. [FBrf0214323] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...