Dror, DmHD-2
Ror proteins are a class of Wnt-binding transmembrane receptor tyrosine kinases - expressed during neural differentiation
Please see the JBrowse view of Dmel\Ror for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
2.272 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
685 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ror using the Feature Mapper tool.
Ror transcripts are first detected at embryonic stage 11. They are expressed in most of the cells of the brain and ventral nerve cord and may be restricted to neurons. They are also present in some cells of the head and trunk that are thought to be sense organs of the PNS.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ror in GBrowse 22-40
2-34.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Phylogenetic analysis of the PTK family.
cDNA encoding Ror identified by screening a late-third-instar larval brain library with a PCR-based approach designed to identify receptor tyrosine kinase-encoding genes: from its DNA sequence and neural-specific expression pattern authors conclude ror protein related to vertebrate neurotrophin receptors.