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Gene Dmel\Ror

General Information
Symbol	Dmel\Ror	Species	D. melanogaster
Name	Ror	Annotation symbol	CG4926
Feature type	protein_coding_gene	FlyBase ID	FBgn0010407
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Dror, DmHD-2
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31B1-31B1	Sequence location	2L:10,251,838..10,254,686 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ror is referred to in FlyBase by the symbol Dmel\Ror (CG4926, FBgn0010407). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: central nervous system development. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Frizzled domain; Kringle; Kringle, conserved site; Kringle-like fold; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, receptor class II, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1626152_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ror. Gene sequence location is 2L:10251838..10254686.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA03414 BKN50988 BKN22146 BKN50057
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31B-31B     (Wilson, 1993.9.21) 31B-31C   (determined by in situ hybridisation)   (Wilson et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ror for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ror-RA FBtr0079978  NM_057614   2276   685
Additional Transcript Data & Comments
Reported size (kB)	2.272 (longest cDNA) (Wilson et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ror-PA   FBpp0079568   78.1   685   7.89     NP_476962   AAF52885
Additional Polypeptide Data & Comments
Reported size (kDa)	685 (aa) (Wilson et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Kringle, conserved site (IPR018056) Kringle (IPR000001) Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, receptor class II, conserved site (IPR002011) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Kringle-like fold (IPR013806) Protein kinase, ATP binding site (IPR017441) Frizzled domain (IPR020067) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52885   AC009849   AC092237   AJ002908 CAA05743   BT125080   CO277353   EC051026   EC053510   EC054525   EC055360   EC055789   EC220617   GH943407   GH948063   GH949064   GH950764   GH951556   GH954747   GH960103   GH961526   GH962801   GH964527   GH967322   GH970511   GH970656   GH978170   GH980937   GH982019   GH984069   L20297 AAA28860
UniProtKB/Swiss-Prot	Q24488
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system | restricted   (Wilson et al., 1993) embryonic stage 11 -- 17   central nervous system   (Wilson et al., 1993)
Additional Descriptive Data
	Ror transcripts are first detected at embryonic stage 11. They are expressed in most of the cells of the brain and ventral nerve cord and may be restricted to neurons. They are also present in some cells of the head and trunk that are thought to be sense organs of the PNS. (Wilson et al., 1993)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010407    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010407 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010407 expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr    1502 embryo 12-14hr    1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr  (388) embryo 08-10hr  (830) embryo 10-12hr  (1502) embryo 12-14hr  (1524) embryo 14-16hr  (835) embryo 16-18hr  (725) embryo 18-20hr  (482) embryo 20-22hr  (306) embryo 22-24hr  (473) larva L1  (323) larva L2  (112) larva L3 12hr old    60 larva L3 puffstage 1-2  (141) larva L3 puffstage 3-6  (255) larva L3 puffstage 7-9  (437) white prepupae new  (456) white prepupae 12hr  (575) white prepupae 24hr  (611) pupae 2d postWPP  (505) pupae 3d postWPP  (215) pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr  1502 embryo 12-14hr  (1524) embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr    1502 embryo 12-14hr    1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr    1502 embryo 12-14hr    1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010407 expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr    1502 embryo 12-14hr    1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr  (388) embryo 08-10hr  (830) embryo 10-12hr  (1502) embryo 12-14hr  (1524) embryo 14-16hr  (835) embryo 16-18hr  (725) embryo 18-20hr  (482) embryo 20-22hr  (306) embryo 22-24hr  (473) larva L1  (323) larva L2  112 larva L3 12hr old    60 larva L3 puffstage 1-2  141 larva L3 puffstage 3-6  (255) larva L3 puffstage 7-9  (437) white prepupae new  (456) white prepupae 12hr  (575) white prepupae 24hr  (611) pupae 2d postWPP  (505) pupae 3d postWPP  (215) pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr  1502 embryo 12-14hr  1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr    1502 embryo 12-14hr    1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    56 embryo 04-06hr    66 embryo 06-08hr    388 embryo 08-10hr    830 embryo 10-12hr    1502 embryo 12-14hr    1524 embryo 14-16hr    835 embryo 16-18hr    725 embryo 18-20hr    482 embryo 20-22hr    306 embryo 22-24hr    473 larva L1    323 larva L2    112 larva L3 12hr old    60 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    437 white prepupae new    456 white prepupae 12hr    575 white prepupae 24hr    611 pupae 2d postWPP    505 pupae 3d postWPP    215 pupae 4d postWPP    64 adult male 01day    80 adult male 05day    78 adult male 30day    88 adult female 01day    27 adult female 05day    17 adult female 30day    19 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010407    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010407 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010407 expression level Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010407 expression level Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    360.075 Larval Midgut    8.6 Larval Hindgut    4.2 Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    5.9 Larval Trachea    2.475 Larval Carcass    3.925 Adult Head    31.6 Adult Eye    6.175 Adult Brain    136.3 Adult Thoracic-Abdominal Ganglion    95.1 Adult Crop    8.3 Adult Midgut no informative data Adult Hindgut    2.5 Adult Malpighian Tubules    4.6 Adult Fat Body    5.3 Adult Salivary Gland    6.4 Adult Heart    3.525 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    4.8 Adult Ovary    4.1 Adult Testis    23.1 Adult Male Accessory Gland    7.8 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.6   NA  Eye    6.175   NA  Brain    136.3   360.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    95.1   NA  Crop    8.3   8.6  Midgut    no informative data   4.2  Hindgut    2.5   5.9  Malpighian Tubules    4.6   no informative data  Fat Body    5.3   5.9  Salivary Gland    6.4   NA  Heart    3.525   2.475  Trachea    NA   NA  VirginFemale Spermatheca    4.5   NA  InseminatedFemale Spermatheca    4.8   NA  Ovary    4.1   NA  Testis    23.1   NA  Male Accessory Gland    7.8   3.925  Carcass    6.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010407 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4926-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 RorGD40 RorGD14377 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ror Class Mutagen Stocks Known lesion Ror41C 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ror Class Mutagen Stocks Known lesion RorGD40 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RorGD14377 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RorGD2536 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)41C (Goberdhan et al., 1999) Df(2L)Exel6026 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD40} NA P{GD2536} NA P{GD14377} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
central nervous system development inferred from expression pattern (assigned by UniProtKB) (Wilson et al., 1993)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002011, InterPro:IPR017441 (FlyBase Curators et al., 2004-) neurotrophin receptor activity non-traceable author statement (Wilson, 1993.9.21) protein tyrosine kinase activity non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity (assigned by UniProtKB) (Wilson et al., 1993) inferred from sequence or structural similarity with EMBL:AB010384 (FlyBase, 1992-) non-traceable author statement (Wilson, 1993.9.21)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR002011, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (assigned by UniProtKB) (Wilson et al., 1993) non-traceable author statement (Morrison et al., 2000) signal transduction inferred from sequence or structural similarity (assigned by UniProtKB) (Wilson et al., 1993) transmembrane receptor protein tyrosine kinase signaling pathway inferred from electronic annotation with InterPro:IPR002011 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane non-traceable author statement (assigned by UniProtKB) (Wilson et al., 1993) membrane inferred from electronic annotation with InterPro:IPR002011 (FlyBase Curators et al., 2004-) plasma membrane inferred from sequence or structural similarity (assigned by UniProtKB) (Wilson et al., 1993)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ror allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0010407 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34367
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15756 Dere\GG10097 Dgri\GH13860 Dmoj\GI19175 Dper\GL19173 Dpse\GA22556 Dsec\GM18059 Dsim\GD23669 Dvir\GJ18109 Dwil\GK23115 Dyak\GE18911
Curated drosophilid orthologs	Dpse\GA18530
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010374-PA Aedes aegypti (mosquito) AGAP006219-PA Anopheles gambiae (mosquito) XP_397058.3 Apis mellifera (honey bee) XP_001948604.1 Acyrthosiphon pisum (pea aphid) 107287 Branchiostoma floridae (lancelet) BGIBMGA010343-PA Bombyx mori (silk worm) ENSBTAP00000016333 Bos taurus (bovine) CN26198 Caenorhabditis brenneri (small nematode) CBP26635 Caenorhabditis briggsae (nematode) CE32563 Caenorhabditis elegans (worm) ENSCAFP00000027493 Canis familiaris (dog) ENSCINP00000006994 Ciona intestinalis (sea squirt) JA12323 Caenorhabditis japonica (nematode) CPIJ013924 Culex pipens (mosquito) ENSCPOP00000000095 Cavia porcellus (guinea pig) RP04876 Caenorhabditis remanei (nematode) ENSCSAVP00000005229 Ciona savignyi (sedentary tunicate) 162027 Capitella spl (polychaete worm) 301267 Daphnia pulex (daphnia) ENSDARP00000065171 Danio rerio (zebra fish) ENSECAP00000021597 Equus caballus (horse) XP_656422 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024672 Gymnopilus aculeatus (mushroom) ENSGALP00000017932 Gallus gallus (chicken) 189258 Hypsipyla robusta (cedar shoot borer) ENSP00000360120 Homo sapiens (human) ISCW010222-PA Ixodes scapularis (deer tick) 51609 Lottia gigantea (owl limpet) ENSMODP00000024012 Monodelphis domestica (gray opossum) ENSMMUP00000006205 Macaca mulatta (rhesus monkey) ENSMUSP00000048171 Mus musculus (house mouse) XP_001601308.1 Nasonia vitripennis (wasp) ENSOANP00000013241 Ornithorynchus anatinus (platypus) ENSORLP00000012786 Oryzias latipes (japanese killifish) LOC_Os05g44960.1 Oryza sativa (asian rice) PF11_0079 Plasmodium falciparum (protozoal parasite) PHUM001280-PA Pediculus humanus (human body louse) PP13814 Pristionchus pacificus (nematode) 41819 Physcomitrella patens (moss) ENSPPYP00000001486 Pongo pygmaeus (orangutan) ENSPTRP00000052236 Pan troglodytes (chimpanzee) ENSRNOP00000044602 Rattus norvegicus (norway rat) XP_001179209.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974512.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021270 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007279 Takifugu rubripes (pufferfish Takifugu) 299.m00012 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000001783 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16237 NV18138 LH19048 ISCW010222 FBgn0236285 FBgn0225077 FBgn0205274 FBgn0195046 FBgn0172966 JGI_V11_301267 JGI_V11_10825 FBgn0243959 FBgn0156772 FBgn0141914 FBgn0121336 FBgn0102409 FBgn0092780 CPIJ013924 BGIBMGA010343 ACYPI004250 GB15884 AGAP006219 AAEL010374 PHUM499580 GLEAN_15667
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v932 w1118; P{GD40}v932 v935 w1118; P{GD40}v935 v29930 w1118 P{GD14377}v29930
Genomic Clones ( 2 )
	BACR07H08 BACR30M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	MIP23956
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	5112 EC051026 EC053510 EC054525 EC055360 EC055789 EK123922 RP004108431 RP004157027 RP004164464 RP004189978 RP004202385 RP004202666 RP004225648 RP004234261 RP004250411 RP004262639 RP004424249 RP004426626 RP004469148 RP004502293 RP004521625 RP004535005 RP004549326
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010407 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34367
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Phylogenetic analysis of the PTK family. (Suga et al., 1997) Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS-induced alleles of bsk. (Goberdhan et al., 1995) cDNA encoding Ror identified by screening a late-third-instar larval brain library with a PCR-based approach designed to identify receptor tyrosine kinase-encoding genes: from its DNA sequence and neural-specific expression pattern authors conclude ror protein related to vertebrate neurotrophin receptors. (Wilson et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057614 RefSeq (Proteins) • NP_476962 DDBJ / EMBL / GenBank • AAA28860 AAF52885 AC009849 AC092237 AJ002908 CAA05743 L20297 Entrez Gene - A searchable database of RefSeq genes. • 34367 UniProtKB/Swiss-Prot • Q24488
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Kringle, conserved site (IPR018056) Kringle (IPR000001) Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, receptor class II, conserved site (IPR002011) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Kringle-like fold (IPR013806) Protein kinase, ATP binding site (IPR017441) Frizzled domain (IPR020067) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0010407 DRSC - Results from RNAi screens. • FBgn0010407 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010407 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4926-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010407 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34367 InParanoid A subset of ortholog calls from InParanoid. • AAEL010374-PA Aedes aegypti (mosquito) AGAP006219-PA Anopheles gambiae (mosquito) XP_397058.3 Apis mellifera (honey bee) XP_001948604.1 Acyrthosiphon pisum (pea aphid) 107287 Branchiostoma floridae (lancelet) BGIBMGA010343-PA Bombyx mori (silk worm) ENSBTAP00000016333 Bos taurus (bovine) CN26198 Caenorhabditis brenneri (small nematode) CBP26635 Caenorhabditis briggsae (nematode) CE32563 Caenorhabditis elegans (worm) ENSCAFP00000027493 Canis familiaris (dog) ENSCINP00000006994 Ciona intestinalis (sea squirt) JA12323 Caenorhabditis japonica (nematode) CPIJ013924 Culex pipens (mosquito) ENSCPOP00000000095 Cavia porcellus (guinea pig) RP04876 Caenorhabditis remanei (nematode) ENSCSAVP00000005229 Ciona savignyi (sedentary tunicate) 162027 Capitella spl (polychaete worm) 301267 Daphnia pulex (daphnia) ENSDARP00000065171 Danio rerio (zebra fish) ENSECAP00000021597 Equus caballus (horse) XP_656422 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024672 Gymnopilus aculeatus (mushroom) ENSGALP00000017932 Gallus gallus (chicken) 189258 Hypsipyla robusta (cedar shoot borer) ENSP00000360120 Homo sapiens (human) ISCW010222-PA Ixodes scapularis (deer tick) 51609 Lottia gigantea (owl limpet) ENSMODP00000024012 Monodelphis domestica (gray opossum) ENSMMUP00000006205 Macaca mulatta (rhesus monkey) ENSMUSP00000048171 Mus musculus (house mouse) XP_001601308.1 Nasonia vitripennis (wasp) ENSOANP00000013241 Ornithorynchus anatinus (platypus) ENSORLP00000012786 Oryzias latipes (japanese killifish) LOC_Os05g44960.1 Oryza sativa (asian rice) PF11_0079 Plasmodium falciparum (protozoal parasite) PHUM001280-PA Pediculus humanus (human body louse) PP13814 Pristionchus pacificus (nematode) 41819 Physcomitrella patens (moss) ENSPPYP00000001486 Pongo pygmaeus (orangutan) ENSPTRP00000052236 Pan troglodytes (chimpanzee) ENSRNOP00000044602 Rattus norvegicus (norway rat) XP_001179209.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974512.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021270 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007279 Takifugu rubripes (pufferfish Takifugu) 299.m00012 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000001783 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/dror.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34367 modMine - Data generated by the modENCODE project. • FBgn0010407 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16237 NV18138 LH19048 ISCW010222 FBgn0236285 FBgn0225077 FBgn0205274 FBgn0195046 FBgn0172966 JGI_V11_301267 JGI_V11_10825 FBgn0243959 FBgn0156772 FBgn0141914 FBgn0121336 FBgn0102409 FBgn0092780 CPIJ013924 BGIBMGA010343 ACYPI004250 GB15884 AGAP006219 AAEL010374 PHUM499580 GLEAN_15667
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG4926 (Morrison et al., 2000, ) DmHD-2 (Oates, 1997.11.10, Oates et al., 1998, ) Dror (Hidalgo, 2002, Jaaro et al., 2001, Goberdhan and Wilson, 2002, Goberdhan et al., 1999, Wilson, 1993.9.21, Huang et al., 1999, Wilson, 1999.3.4, Oates et al., 1998, Suga et al., 1997, Goberdhan et al., 1997, Wilson et al., 1997, Wilson et al., 1995, Steller and Grether, 1994, Wilson et al., 1993, ) DRor (Bai and Montell, 1998) HD-2   ROR (Rehn et al., 1998) Ror (Reeves and Posakony, 2005, Korcsmáros et al., 2011) ROR1 (Banyai and Patthy, 2004)
Name Synonym	Ror
Secondary FlyBase IDs
	FBgn0022797
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Korcsmáros et al., 2011, PLoS ONE 6(5): e19240 Signalogs: orthology-based identification of novel signaling pathway components in three metazoans. [FBrf0213696] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...