FlyBase Gene Report: Dmel\Ror

General Information

Symbol

Dmel\Ror

Species

D. melanogaster

Name

Ror

Annotation Symbol

CG4926

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010407

Gene Model Status

Current

Stock Availability

5 publicly available

Enzyme Name (EC)

Receptor protein-tyrosine kinase (2.7.10.1)

Gene Snapshot

Ror (Ror) encodes a transmembrane receptor tyrosine kinase structurally related to vertebrate neural-specific Wnt-binding Ror receptors. It is primarily expressed in the nervous system and it is likely to signal through the ERK MAP kinase pathway. [Date last reviewed: 2018-09-13]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dror, DmHD-2

Key Links

Genomic Location

Cytogenetic map

31B1-31B1

Sequence location

2L:10,251,843..10,254,686 [+]

Recombination map

2-40

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (Q24488)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

Predictions / Assertions

ATP binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)

Summaries

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Protein Function (UniProtKB)

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

(UniProt, Q24488)

Summary (Interactive Fly)

Ror proteins are a class of Wnt-binding transmembrane receptor tyrosine kinases - expressed during neural differentiation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Ror or the JBrowse view of Dmel\Ror for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ror-RA

FBtr0079978

NM_057614

2271

685

Additional Transcript Data and Comments

Reported size (kB)

2.272 (longest cDNA)

(Wilson et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ror-PA

FBpp0079568

78.1

685

7.89

NP_476962

AAF52885

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

685 (aa)

(Wilson et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q24488

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ror using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ror_1

Linkouts

Gene Ontology (19 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002011, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

protein tyrosine kinase activity

non-traceable author statement

(assigned by UniProt )

(Wilson et al., 1993)

transmembrane receptor protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

Wnt-protein binding

inferred from biological aspect of ancestor with PANTHER:PTN002400490

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (11 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

central nervous system development

inferred from expression pattern

(assigned by UniProt )

(Wilson et al., 1993)

Terms Based on Predictions or Assertions (10 terms)

CV Term

Evidence

References

anatomical structure development

inferred from biological aspect of ancestor with PANTHER:PTN002400490

(assigned by GO_Central )

(Gaudet et al., 2011)

multicellular organism development

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

nervous system development

inferred from biological aspect of ancestor with PANTHER:PTN002400475

(assigned by GO_Central )

(Gaudet et al., 2011)

positive regulation of kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

positive regulation of MAPK cascade

inferred from biological aspect of ancestor with PANTHER:PTN002400475

(assigned by GO_Central )

(Gaudet et al., 2011)

positive regulation of neuron projection development

inferred from biological aspect of ancestor with PANTHER:PTN002400475

(assigned by GO_Central )

(Gaudet et al., 2011)

positive regulation of phosphatidylinositol 3-kinase signaling

inferred from biological aspect of ancestor with PANTHER:PTN002400475

(assigned by GO_Central )

(Gaudet et al., 2011)

protein phosphorylation

non-traceable author statement

(assigned by UniProt )

(Wilson et al., 1993)

regulation of MAPK cascade

inferred from biological aspect of ancestor with PANTHER:PTN002400475

(assigned by GO_Central )

(Gaudet et al., 2011)

transmembrane receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

axon

inferred from biological aspect of ancestor with PANTHER:PTN000699763

(assigned by GO_Central )

(Gaudet et al., 2011)

integral component of membrane

non-traceable author statement

(assigned by UniProt )

(Wilson et al., 1993)

integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 17

central nervous system

(Wilson et al., 1993)

embryonic stage

presumptive embryonic/larval peripheral nervous system | restricted

(Wilson et al., 1993)

Additional Descriptive Data

Ror transcripts are first detected at embryonic stage 11. They are expressed in most of the cells of the brain and ventral nerve cord and may be restricted to neurons. They are also present in some cells of the head and trunk that are thought to be sense organs of the PNS.

(Wilson et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ror in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ror

View exonic expression by tissue for Dmel\Ror

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010407

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4926-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0010407

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ror

Transgenic constructs containing regulatory region of Ror

Deletions and Duplications ( 2 )

Disrupted in

Df(2L)41C

(Goberdhan et al., 1999)

Df(2L)Exel6026

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ror⁴

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Ror^GD40

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Ror^GD40

Sterility

Allele

fertile

Ror⁴

Other Phenotypes

Allele

some die during embryonic stage

Ror⁴

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ROR2

14 of 15

Yes

Hsap\ROR1

13 of 15

Yes

Hsap\NTRK2

1 of 15

Yes

Hsap\NTRK3

1 of 15

Yes

Hsap\PTK7

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ror1

14 of 15

Yes

Mmus\Ror2

12 of 15

Yes

Mmus\Ntrk1

1 of 15

Yes

Mmus\Ntrk2

1 of 15

Yes

Mmus\Ntrk3

1 of 15

Yes

Mmus\Ptk7

1 of 15

Rattus norvegicus (Norway rat) (7)

Rnor\Ror2

9 of 13

Yes

Rnor\Ror1

8 of 13

Yes

Rnor\Musk

1 of 13

Rnor\Ntrk1

1 of 13

Yes

Rnor\Ntrk2

1 of 13

Yes

Rnor\Ntrk3

1 of 13

Yes

Rnor\Ptk7

1 of 13

Xenopus tropicalis (Western clawed frog) (4)

Xtro\ror2

10 of 12

Yes

Xtro\ror1

7 of 12

Yes

Xtro\musk

1 of 12

Xtro\ntrk1

1 of 12

Yes

Danio rerio (Zebrafish) (8)

Drer\ror1

14 of 15

Yes

Drer\ror2

13 of 15

Yes

Drer\myot

1 of 15

Yes

Drer\ntrk1

1 of 15

Yes

Drer\ntrk2a

1 of 15

Yes

Drer\ntrk2b

1 of 15

Yes

Drer\ntrk3a

1 of 15

Yes

Drer\ntrk3b

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\cam-1

13 of 15

Yes

Cele\trk-1

1 of 15

Yes

Cele\W03A5.1

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (61)

Atha\AT1G11050

1 of 9

Yes

Atha\AT1G15530

1 of 9

Yes

Atha\AT1G25390

1 of 9

Yes

Atha\AT1G66910

1 of 9

Yes

Atha\AT1G66920

1 of 9

Yes

Atha\AT2G43700

1 of 9

Yes

Atha\AT3G08870

1 of 9

Yes

Atha\AT3G45330

1 of 9

Yes

Atha\AT3G45410

1 of 9

Yes

Atha\AT3G45420

1 of 9

Yes

Atha\AT3G45430

1 of 9

Yes

Atha\AT3G45440

1 of 9

Yes

Atha\AT3G53380

1 of 9

Yes

Atha\AT3G53810

1 of 9

Yes

Atha\AT3G59750

1 of 9

Yes

Atha\AT4G11900

1 of 9

Yes

Atha\AT4G28350

1 of 9

Yes

Atha\AT4G29050

1 of 9

Yes

Atha\AT5G02070

1 of 9

Yes

Atha\AT5G03140

1 of 9

Yes

Atha\AT5G10530

1 of 9

Yes

Atha\AT5G24080

1 of 9

Yes

Atha\AT5G59270

1 of 9

Yes

Atha\AT5G60270

1 of 9

Yes

Atha\AT5G60280

1 of 9

Yes

Atha\AT5G60310

1 of 9

Yes

Atha\AT5G60320

1 of 9

Yes

Atha\AT5G65600

1 of 9

Yes

Atha\AT5G66790

1 of 9

Yes

Atha\CCR4

1 of 9

Yes

Atha\CRK3

1 of 9

Yes

Atha\CRK11

1 of 9

Yes

Atha\CRK12

1 of 9

Yes

Atha\CRK13

1 of 9

Yes

Atha\CRK14

1 of 9

Yes

Atha\CRK15

1 of 9

Yes

Atha\CRK18

1 of 9

Yes

Atha\CRK21

1 of 9

Yes

Atha\CRK22

1 of 9

Yes

Atha\CRK23

1 of 9

Yes

Atha\CRK24

1 of 9

Yes

Atha\CRK30

1 of 9

Yes

Atha\CRK31

1 of 9

Yes

Atha\CRK32

1 of 9

Yes

Atha\CRK33

1 of 9

Yes

Atha\CRK34

1 of 9

Yes

Atha\CRK36

1 of 9

Yes

Atha\CRK37

1 of 9

Yes

Atha\CRK38

1 of 9

Yes

Atha\CRK39

1 of 9

Yes

Atha\CRK40

1 of 9

Yes

Atha\CRK42

1 of 9

Yes

Atha\EMB1290

1 of 9

Yes

Atha\FEI1

1 of 9

Yes

Atha\GSO2

1 of 9

Yes

Atha\HLECRK

1 of 9

Yes

Atha\LECRKA4.1

1 of 9

Yes

Atha\LECRKA4.2

1 of 9

Yes

Atha\LECRKA4.3

1 of 9

Yes

Atha\RKF3

1 of 9

Yes

Atha\WAKL1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919052G )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Ror

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila persimilis

Dper\GL19173

Drosophila willistoni

Dwil\GK23115

Drosophila virilis

Dvir\GJ18109

Drosophila mojavensis

Dmoj\GI19175

Drosophila grimshawi

Dgri\GH13860

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501RW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17006767

Musca domestica

House fly

Mdoa\17004540

Glossina morsitans

Tsetse fly

Gmor\GMOY010164

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00746

Mayetiola destructor

Hessian fly

Mdes\Mdes005897

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010374

Anopheles darlingi

American malaria mosquito

Adar\ADAC007123

Anopheles gambiae

Malaria mosquito

Agam\AGAP006219

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013924

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01YE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010343

Bombyx mori

Silkmoth

Bmor\BGIBMGA005972

Danaus plexippus

Monarch butterfly

Dple\DPOGS214255-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS208555-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016441

Heliconius melpomene

Postman butterfly

Hmel\HMEL011371

Apis florea

Little honeybee

Aflo\2969672340

Apis florea

Little honeybee

Aflo\4731185556

Apis mellifera

Western honey bee

Amel\GB53257

Apis mellifera

Western honey bee

Amel\GB47894

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15521

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12323

Bombus terrestris

Buff-tailed bumblebee

Bter\15204943

Bombus terrestris

Buff-tailed bumblebee

Bter\15206457

Linepithema humile

Argentine ant

Lhum\LH19048

Linepithema humile

Argentine ant

Lhum\LH24858

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00301a

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00014b

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG021211

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002509

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11249

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05084

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05082

Tribolium castaneum

Red flour beetle

Tcas\TC013538

Tribolium castaneum

Red flour beetle

Tcas\TC013537

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15667

Pediculus humanus

Human body louse

Phum\PHUM462240

Pediculus humanus

Human body louse

Phum\PHUM499580

Rhodnius prolixus

Kissing bug

Rpro\Ror

Rhodnius prolixus

Kissing bug

Rpro\RPRC001869

Cimex lectularius

Bed bug

Clec\CLEC007160

Cimex lectularius

Bed bug

Clec\CLEC000342

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI086063

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004250

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001925

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06884

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17460

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01W1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005489

Strigamia maritima

European centipede

Smar\SMAR002406

Strigamia maritima

European centipede

Smar\SMAR000930

Ixodes scapularis

Black-legged tick

Isca\ISCW016861

Ixodes scapularis

Black-legged tick

Isca\ISCW010222

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80935.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72830.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur13g02670

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g04430

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g01050

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g04400

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_301267

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_42382

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_4188

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_10825

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02W3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-RorL

Ciona intestinalis

Vase tunicate

Cint\LOC100184478

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021725

Ciona intestinalis

Vase tunicate

Cint\LOC100176053

Ciona intestinalis

Vase tunicate

Cint\LOC100182117

Gallus gallus

Domestic chicken

Ggal\ROR2

Gallus gallus

Domestic chicken

Ggal\ROR1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (23)

Gene Symbol

Score

Source

Alignment

Nrk

3 of 10

Alk

2 of 10

Ddr

2 of 10

InR

2 of 10

otk

2 of 10

sev

2 of 10

btl

1 of 10

Cad96Ca

1 of 10

CG3277

1 of 10

CG10702

1 of 10

dnt

1 of 10

Drl-2

1 of 10

drl

1 of 10

Egfr

1 of 10

Eph

1 of 10

htl

1 of 10

otk2

1 of 10

Pvr

1 of 10

Ret

1 of 10

Sdr

1 of 10

smal

1 of 10

Tie

1 of 10

tor

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ROR2; receptor tyrosine kinase like orphan receptor 2

model of brachydactyly type B1

IEA

(FlyBase, 2019-)

model of autosomal recessive Robinow syndrome

IEA

(FlyBase, 2019-)

ROR1; receptor tyrosine kinase like orphan receptor 1

model of autosomal recessive nonsyndromic deafness 108

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ROR2; receptor tyrosine kinase like orphan receptor 2

14 of 15

602337

ROR1; receptor tyrosine kinase like orphan receptor 1

13 of 15

602336

DEAFNESS, AUTOSOMAL RECESSIVE 108; DFNB108

autosomal recessive nonsyndromic deafness 108

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ror - Wnt4

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - Wnt5

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - fz2

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - otk

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Ror - wg

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010407

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34367

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-40

Cytogenetic map

31B1-31B1

Sequence location

2L:10,251,843..10,254,686 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31B1-31B1

Limits computationally determined from genome sequence between P{lacW}me31B^k06607 and P{PZ}nmd⁰⁸⁷⁷⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

31B-31B

(Wilson, 1993.9.21)

31B-31C

(determined by in situ hybridisation)

(Wilson et al., 1993)

Experimentally Determined Recombination Data

Location

2-40

(FlyBase, 2016)

2-34.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

62868

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05341}attP40

Kyoto

201394

y¹ w^67c23; P{GSV3}Ror^GS8107/SM1

VDRC

v932

w¹¹¹⁸; P{GD40}v932

v29930

w¹¹¹⁸ P{GD14377}v29930

v341078

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00095}attP40/CyO-GFP

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

MIP23956

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010407

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010407

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34367

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

(Oates, 1997.11.10)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Phylogenetic analysis of the PTK family.

(Suga et al., 1997)

Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS-induced alleles of bsk.

(Goberdhan et al., 1995)

cDNA encoding Ror identified by screening a late-third-instar larval brain library with a PCR-based approach designed to identify receptor tyrosine kinase-encoding genes: from its DNA sequence and neural-specific expression pattern authors conclude ror protein related to vertebrate neurotrophin receptors.

(Wilson et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34367

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24488

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010407

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ror_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0010407

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34367

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4926

modMine - A data warehouse for the modENCODE project

FBgn0010407

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010407

DRSC - Results frm RNAi screens

FBgn0010407

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010407

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4926-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010407

FlyMine - An integrated database for Drosophila genomics

FBgn0010407

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34367

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG4926

(Neuert et al., 2017, Vogel et al., 2013, Perkins et al., 2009, Morrison et al., 2000)

DRor

(Bai and Montell, 1998)

DmHD-2

(Oates et al., 1998, Oates, 1997.11.10)

Dror

(Goberdhan and Wilson, 2002, Hidalgo, 2002, Jaaro et al., 2001, Goberdhan et al., 1999, Huang et al., 1999, Wilson, 1999.3.4, Oates et al., 1998, Goberdhan et al., 1997, Suga et al., 1997, Wilson et al., 1997, Wilson et al., 1995, Steller and Grether, 1994, Wilson, 1993.9.21, Wilson et al., 1993)

HD-2

ROR

(Rehn et al., 1998)

ROR1

(Banyai and Patthy, 2004)

Ror

(Ripp et al., 2018, Neuert et al., 2017, Aradska et al., 2015, Sopko and Perrimon, 2013, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012, Korcsmáros et al., 2011, Reeves and Posakony, 2005)

Name Synonyms

Ror

Secondary FlyBase IDs

FBgn0022797

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (60)

Report Sections

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