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Gene Dmel\RpL18A

General Information
Symbol	Dmel\RpL18A	Species	D. melanogaster
Name	Ribosomal protein L18A	Annotation symbol	CG6510
Feature type	protein_coding_gene	FlyBase ID	FBgn0010409
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	L18A
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C3-54C3	Sequence location	2R:13,433,895..13,434,999 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L18A is referred to in FlyBase by the symbol Dmel\RpL18A (CG6510, FBgn0010409). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization; centrosome duplication. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L18a; Ribosomal protein L18a/LX. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636056_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL18A. Gene sequence location is 2R:13433895..13434999.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Müller et al., 2010, EMBO J. 29(19): 3344--3357 Controlled Vocabulary Terms centrosome duplication Sequence features BKN22638 HFA07538
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C3-54C3   Limits computationally determined from genome sequence between P{lacW}l(2)k07433k07433 and P{EP}MESR4EP988
Experimentally Determined Cytological Location
Cytogenetic map Notes References 54B-54B   (determined by in situ hybridisation)   (Ntwasa et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpL18A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL18A-RA FBtr0086947  NM_079050   683   177
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL18A-PA   FBpp0086103   21.0   177   11.26     NP_523774   AAF57838
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L18a/LX (IPR023573) Ribosomal protein L18a (IPR021138)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695900   AA696790   AA735626   AA736067   AA801762   AA803504   AA803788   AA803852   AA816766   AA949228   AA979154   AE013599 AAF57838   AF083520   AI062286   AI062887   AI063493   AI064603   AI106598   AI107554   AI107707   AI110160   AI114368   AI239081   AI257348   AI257539   AI257895   AI258760   AI259794   AI260028   AI260631   AI293152   AI293706   AI295408   AI296148   AI297088   AI297188   AI297392   AI297601   AI387559   AI387912   AI403383   AI456599   AI456692   AI512648   AI513424   AI514234   AI514238   AI515448   AI515695   AI516561   AI516643   AI517378   AI517890   AI519923   AI520273   AI534651   AY071222 AAL48844   AY231805   AY232187   AY440829   AY826136   BF499068   BG632335   BG632851   BG634794   BG635093   BG635461   BG635546   BG635763   BG635916   BG636053   BG636336   BG636338   BG636511   BG636656   BG639375   BG640586   BG641145   BG641155   BG641160   BH759246   BI162466   BI162467   BI162897   BI163850   BI163950   BI163967   BI164623   BI164905   BI166963   BI167207   BI167578   BI167900   BI168352   BI170608   BI170671   BI172297   BI172809   BI173482   BI173741   BI173914   BI214676   BI214792   BI215321   BI215428   BI216017   BI228499   BI228745   BI228841   BI229706   BI230197   BI230285   BI232334   BI233017   BI235223   BI235440   BI235635   BI235715   BI235887   BI237010   BI238989   BI239306   BI239594   BI240118   BI242088   BI242822   BI242925   BI351701   BI352040   BI352055   BI352108   BI352380   BI352497   BI352498   BI352513   BI352541   BI352653   BI352734   BI352854   BI352967   BI353127   BI353398   BI353493   BI353528   BI353666   BI353686   BI354177   BI354837   BI355138   BI355237   BI355665   BI356264   BI357528   BI357762   BI357823   BI358074   BI358270   BI358312   BI362022   BI362259   BI362709   BI363214   BI363284   BI363394   BI363553   BI364201   BI364258   BI364977   BI365786   BI365842   BI369525   BI370614   BI371855   BI372496   BI373625   BI373678   BI374232   BI374557   BI375086   BI481900   BI482008   BI482460   BI485145   BI485356   BI485380   BI485896   BI486184   BI486411   BI486722   BI564587   BI564642   BI564825   BI564888   BI565540   BI566989   BI567639   BI567655   BI567724   BI567806   BI567986   BI568225   BI568329   BI568371   BI568600   BI568618   BI569510   BI569517   BI569664   BI569708   BI569862   BI570239   BI570257   BI570368   BI570535   BI570783   BI570876   BI571192   BI571213   BI572411   BI572561   BI572637   BI572668   BI573214   BI574785   BI574802   BI574930   BI575067   BI575211   BI575429   BI575453   BI575555   BI575561   BI575642   BI576097   BI576531   BI577786   BI578328   BI578597   BI580632   BI581348   BI581480   BI581794   BI581795   BI582148   BI582460   BI582644   BI583310   BI584255   BI585955   BI586309   BI586397   BI587007   BI587044   BI588490   BI589564   BI589651   BI589888   BI589978   BI590318   BI590373   BI590447   BI590685   BI591184   BI591454   BI591499   BI591972   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BI625227   BI625362   BI625434   BI625635   BI625976   BI626015   BI626140   BI626242   BI626275   BI626330   BI626380   BI626999   BI627114   BI627260   BI628196   BI628354   BI628520   BI628775   BI628939   BI629731   BI629983   BI630613   BI631160   BI631289   BI631486   BI631697   BI631762   BI631976   BI632827   BI633126   BI633236   BI634625   BI634858   BI635117   BI635491   BI636081   BI636387   BI636914   BI637444   BI637752   BI638768   BI638792   BI639232   BI639561   BI639700   BI640537   BI641788   BP540526   BP542462   BP542805   BP542868   BP542917   BP542933   BP542969   BP543605   BP543880   BP544100   BP544898   BP545297   BP545301   BP545415   BP546556   BP546974   BP547515   BP547919   BP547940   BP548081   BP548903   BP549169   BP549362   BP549512   BP549739   BP550423   BP550577   BP550971   BP551037   BP551139   BP551159   BP551246   BP551405   BP552204   BP552412   BP552694   BP553193   BP553199   BP553707   BP554101   BP554262   BP554267   BP554721   BP555082   BP555194   BP555641   BP555654   BP556129   BP556138   BP556169   BP556498   BP557243   BP557437   BP557506   BP557680   BP557721   BP558249   BP559138   BP559410   BP559502   BP559658   BQ103199   BQ103415   BQ103449   BX005613   BX006466   BX009965   BX012161   BX013895   BX013918   BX013942   BX014827   BX015087   BX016522   BX019550   BX021912   BX022474   BX024700   BX026453   BX026727   BX027949   BX028058   BX028234   BX029758   BX029790   BX031003   BX032691   BX033571   BX034833   BX034964   BX036672   BX036706   BX037325   BX037437   BX037572   BX037981   BX039242   BX039244   BX040164   BX040328   BX040440   BX040652   BX040892   BX041065   BX041092   BX041184   BX041371   BX041494   BX041739   BX041828   BX041869   BX041897   BX041980   BX041997   BX042165   BX042191   BX042372   BX042566   BX042750   BX042812   BX042913   BX043086   BX043158   BX043361   BX043401   BX043812   BX044022   BX044205   BX044233   BX044585   BX044673   BX044861   BX045056   BX045304   BX045647   BX045657   BX045771   BX045862   BX046324   BX046689   BX046754   BX046825   BX046875   BX046939   BX047000   BX047141   BX047155   BX047216   BX047279   BX047478   BX047754   BX048120   BX048131   BX048134   BX048695   BX048769   BX048811   BX048922   BX049058   BX049415   BX049608   BX049717   BX049989   BX050494   BX050606   BX050970   BX051854   BX051884   BX051919   BX051980   BX052003   BX052466   BX052509   BX052572   BX052628   BX052678   BX052785   BX053165   BX053392   BX053786   BX054095   BX054489   BX054550   BX055118   BX055221   BX055404   BX055477   BX055541   BX055565   BX055642   BX055716   BX055723   BX055739   BX056039   BX056309   BX056478   BX056552   BX056571   BX056601   BX056752   BX056776   BX056891   BX057086   BX057958   BX058269   BX058280   BX058559   BX058807   BX058871   BX059230   BX059262   BX059276   BX059597   BX059979   BX060046   BX060072   BX060155   BX060314   BX060474   BX060939   BX061184   BX061291   BX061383   BX061452   BX061844   BX062090   BX062118   BX062165   BX062624   BX062755   BX062805   BX062912   BX062930   BX063027   BX063629   BX063678   BX063680   BX064041   BX065032   BX065079   BX065085   BX065103   BX065286   BX065398   BX065562   BX065768   BX065925   BX066444   BX066697   BX066842   BX066931   BX066998   BX067101   BX067730   BX068003   BX068264   BX068270   BX068304   BX068334   BX068342   BX068389   BX068631   BX068698   BX068780   BX068891   BX068917   BX069213   BX069368   BX069702   BX069940   BX069977   BX070094   BX071021   BX071133   BX071197   BX071326   BX071885   BX071934   BX072010   CA803936   CA804802   CA804998   CA805434   CK131763   CK132012   CK132135   CK135583   CK660261   CK660448   CK661233   CK661349   CK661527   CK662189   CO152736   CO152893   CO153125   CO153333   CO153370   CO153412   CO153880   CO153883   CO154043   CO154168   CO154203   CO154537   CO155480   CO155596   CO155852   CO156955   CO180050   CO180087   CO181711   CO182977   CO184764   CO184806   CO187111   CO190314   CO192190   CO193049   CO194406   CO195320   CO275758   CO280889   CO300728   CO301630   CO307228   CO309473   CO329896   CO332200   CO335428   CO336337   CO336878   CO337725   CO337998   CO338575   CO338662   EC065070   EC066086   EC067384   EC068992   EC069447   EC071501   EC073372   EC078865   EC079265   EC080756   EC081747   EC085460   EC087375   EC197459   EC214997   EC216605   EC226821   EC227834   EC229870   EC260788   EC260928   EC261677   EC261921   EC262055   EC262324   EC262571   EC262682   EC262748   EC263120   EC263589   EC264066   EC264594   EC264623   EC265235   EC265553   EC265879   EC266043   EC266346   EC266724   EC266830   EC267072   EC267248   EC267283   EC268037   EL869940   EL870026   EL870406   EL870408   EL870410   EL870412   EL876851   EL878244   EL880208   EL880483   EV576654   EV577778   EV578089   EV578202   EV578245   EV580615   EV580789   EV581086   EV581648   EV582474   EV583019   EV583102   EV584457   EV584735   EV585726   EV587805   EV588791   EV589144   EV590520   EV592712   EV593365   EV593533   EV593894   EV595092   EV596082   EV596904   EV597054   EV597543   EV598454   EV599189   EV599454   EV599576   GH748029   GH748079   GH749046   GH749999   GH750519   GH751647   GH751734   GH752000   GH753524   GH754110   GH755368   GH755539   GH755721   GH755898   GH756626   GH756790   GH760777   GH761182   GH770995   GH772647   GH773012   GH773435   GH774701   GH775036   GH775251   GH776212   GH776564   GH776834   GH777256   GH777424   GH777594   GH777814   GH780217   GH780891   GH781746   GH782212   GH782956   GH783442   GH784830   GH785411   GH787691   GH788077   GH788178   GH788261   GH789208   GH789635   GH790037   GH790416   GH790722   GH790725   GH791137   GH791191   GH791452   GH791836   GH792399   GH793475   GH793966   GH795474   GH795855   GH796411   GH796934   GH797145   GH797680   GH797871   GH797899   GH797910   GH798536   GH799434   GH799483   GH801495   GH801672   GH801862   GH802163   GH803642   GH804230   GH805358   GH805371   GH806293   GH807140   GH807585   GH807669   GH809458   GH811275   GH813113   GH813835   GH814604   GH818055   GH818232   GH818266   GH819402   GH820362   GH820867   GH821026   GH821547   GH822527   GH823623   GH823734   GH823900   GH824187   GH824329   GH825075   GH827097   GH827850   GH828839   GH832123   GH832400   GH832575   GH833002   GH833117   GH833509   GH833967   GH834105   GH834228   GH835072   GH835932   GH836778   GH837397   GH837451   GH837651   GH837793   GH837831   GH838124   GH838288   GH839055   GH845220   GH847232   GH847787   GH847827   GH848044   GH848619   GH849618   GH849672   GH851764   GH852119   GH853661   GH854510   GH855090   GH855887   GH856127   GH857249   GH857366   GH859784   GH859859   GH861981   GH862126   GH862480   GH862710   GH863681   GH864101   GH864558   GH865066   GH865338   GH865995   GH867178   GH867875   GH868730   GH871218   GH871703   GH872166   GH872545   GH873377   GH874103   GH874718   GH875218   GH876322   GH877005   GH877052   GH877405   GH878190   GH878708   GH879406   GH881319   GH882786   GH884382   GH885369   GH886527   GH886569   GH886638   GH886912   GH887122   GH887546   GH887692   GH887965   GH888631   GH888780   GH890002   GH890239   GH890415   GH890803   GH890951   GH893137   GH893485   GH893493   GH894564   GH895315   GH895766   GH895851   GH898478   GH899176   GH899756   GH900179   GH901528   GH902309   GH902706   GH903072   GH903461   GH904954   GH904962   GH905198   GH905464   GH905589   GH905669   GH905730   GH905754   GH906140   GH906786   GH909124   GH909721   GH909946   GH910066   GH910572   GH912016   GH912149   GH913711   GH914020   GH914185   GH914249   GH914493   GH915181   GH917502   GH918091   GH918313   GH918350   GH918798   GH919446   GH919533   GH920268   GH922498   GH923258   GH923841   GH925498   GH925687   GH925849   GH926077   GH926400   GH926431   GH927242   GH928298   GH928401   GH929686   GH930999   GH931266   GH932110   GH934201   GH934389   GH935941   GH936711   GH938264   GH938471   X75339 CAA53089
UniProtKB/Swiss-Prot	P41093
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010409    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010409 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010409 expression level Developmental Stage   Expression Level embryo 00-02hr    148693 embryo 02-04hr    217897 embryo 04-06hr    201418 embryo 06-08hr    219772 embryo 08-10hr    219251 embryo 10-12hr    228335 embryo 12-14hr    171318 embryo 14-16hr    236368 embryo 16-18hr    201467 embryo 18-20hr    227851 embryo 20-22hr    237807 embryo 22-24hr    211842 larva L1    296035 larva L2    223489 larva L3 12hr old    186985 larva L3 puffstage 1-2    154186 larva L3 puffstage 3-6    146508 larva L3 puffstage 7-9    152902 white prepupae new    148036 white prepupae 12hr    128782 white prepupae 24hr    134762 pupae 2d postWPP    106244 pupae 3d postWPP    87306 pupae 4d postWPP    102724 adult male 01day    73387 adult male 05day    76285 adult male 30day    97715 adult female 01day    195500 adult female 05day    169688 adult female 30day    185966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (148693) embryo 02-04hr  (217897) embryo 04-06hr  (201418) embryo 06-08hr  (219772) embryo 08-10hr  (219251) embryo 10-12hr  (228335) embryo 12-14hr  (171318) embryo 14-16hr  (236368) embryo 16-18hr  (201467) embryo 18-20hr  (227851) embryo 20-22hr  (237807) embryo 22-24hr  (211842) larva L1  (296035) larva L2  (223489) larva L3 12hr old  (186985) larva L3 puffstage 1-2  (154186) larva L3 puffstage 3-6  (146508) larva L3 puffstage 7-9  (152902) white prepupae new  (148036) white prepupae 12hr  (128782) white prepupae 24hr  (134762) pupae 2d postWPP  (106244) pupae 3d postWPP  (87306) pupae 4d postWPP  (102724) adult male 01day  (73387) adult male 05day  (76285) adult male 30day  (97715) adult female 01day  (195500) adult female 05day  (169688) adult female 30day  (185966) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (148693) embryo 02-04hr  (217897) embryo 04-06hr  (201418) embryo 06-08hr  (219772) embryo 08-10hr  (219251) embryo 10-12hr  (228335) embryo 12-14hr  (171318) embryo 14-16hr  (236368) embryo 16-18hr  (201467) embryo 18-20hr  (227851) embryo 20-22hr  (237807) embryo 22-24hr  (211842) larva L1  (296035) larva L2  (223489) larva L3 12hr old  (186985) larva L3 puffstage 1-2  (154186) larva L3 puffstage 3-6  (146508) larva L3 puffstage 7-9  (152902) white prepupae new  (148036) white prepupae 12hr  (128782) white prepupae 24hr  (134762) pupae 2d postWPP  (106244) pupae 3d postWPP  (87306) pupae 4d postWPP  (102724) adult male 01day  (73387) adult male 05day  (76285) adult male 30day  (97715) adult female 01day  (195500) adult female 05day  (169688) adult female 30day  (185966) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (148693) embryo 02-04hr  (217897) embryo 04-06hr  (201418) embryo 06-08hr  (219772) embryo 08-10hr  (219251) embryo 10-12hr  (228335) embryo 12-14hr  (171318) embryo 14-16hr  (236368) embryo 16-18hr  (201467) embryo 18-20hr  (227851) embryo 20-22hr  (237807) embryo 22-24hr  (211842) larva L1  (296035) larva L2  (223489) larva L3 12hr old  (186985) larva L3 puffstage 1-2  (154186) larva L3 puffstage 3-6  (146508) larva L3 puffstage 7-9  (152902) white prepupae new  (148036) white prepupae 12hr  (128782) white prepupae 24hr  (134762) pupae 2d postWPP  (106244) pupae 3d postWPP  (87306) pupae 4d postWPP  (102724) adult male 01day  (73387) adult male 05day  (76285) adult male 30day  (97715) adult female 01day  (195500) adult female 05day  (169688) adult female 30day  (185966) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    148693 embryo 02-04hr    217897 embryo 04-06hr    201418 embryo 06-08hr    219772 embryo 08-10hr    219251 embryo 10-12hr    228335 embryo 12-14hr    171318 embryo 14-16hr    236368 embryo 16-18hr    201467 embryo 18-20hr    227851 embryo 20-22hr    237807 embryo 22-24hr    211842 larva L1    296035 larva L2    223489 larva L3 12hr old    186985 larva L3 puffstage 1-2    154186 larva L3 puffstage 3-6    146508 larva L3 puffstage 7-9    152902 white prepupae new    148036 white prepupae 12hr    128782 white prepupae 24hr    134762 pupae 2d postWPP    106244 pupae 3d postWPP    87306 pupae 4d postWPP    102724 adult male 01day    73387 adult male 05day    76285 adult male 30day    97715 adult female 01day    195500 adult female 05day    169688 adult female 30day    185966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010409 expression level Developmental Stage   Expression Level embryo 00-02hr    148693 embryo 02-04hr    217897 embryo 04-06hr    201418 embryo 06-08hr    219772 embryo 08-10hr    219251 embryo 10-12hr    228335 embryo 12-14hr    171318 embryo 14-16hr    236368 embryo 16-18hr    201467 embryo 18-20hr    227851 embryo 20-22hr    237807 embryo 22-24hr    211842 larva L1    296035 larva L2    223489 larva L3 12hr old    186985 larva L3 puffstage 1-2    154186 larva L3 puffstage 3-6    146508 larva L3 puffstage 7-9    152902 white prepupae new    148036 white prepupae 12hr    128782 white prepupae 24hr    134762 pupae 2d postWPP    106244 pupae 3d postWPP    87306 pupae 4d postWPP    102724 adult male 01day    73387 adult male 05day    76285 adult male 30day    97715 adult female 01day    195500 adult female 05day    169688 adult female 30day    185966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (148693) embryo 02-04hr  (217897) embryo 04-06hr  (201418) embryo 06-08hr  (219772) embryo 08-10hr  (219251) embryo 10-12hr  (228335) embryo 12-14hr  (171318) embryo 14-16hr  (236368) embryo 16-18hr  (201467) embryo 18-20hr  (227851) embryo 20-22hr  (237807) embryo 22-24hr  (211842) larva L1  (296035) larva L2  (223489) larva L3 12hr old  (186985) larva L3 puffstage 1-2  (154186) larva L3 puffstage 3-6  (146508) larva L3 puffstage 7-9  (152902) white prepupae new  (148036) white prepupae 12hr  (128782) white prepupae 24hr  (134762) pupae 2d postWPP  (106244) pupae 3d postWPP  (87306) pupae 4d postWPP  (102724) adult male 01day  (73387) adult male 05day  (76285) adult male 30day  (97715) adult female 01day  (195500) adult female 05day  (169688) adult female 30day  (185966) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (148693) embryo 02-04hr  (217897) embryo 04-06hr  (201418) embryo 06-08hr  (219772) embryo 08-10hr  (219251) embryo 10-12hr  (228335) embryo 12-14hr  (171318) embryo 14-16hr  (236368) embryo 16-18hr  (201467) embryo 18-20hr  (227851) embryo 20-22hr  (237807) embryo 22-24hr  (211842) larva L1  (296035) larva L2  (223489) larva L3 12hr old  (186985) larva L3 puffstage 1-2  (154186) larva L3 puffstage 3-6  (146508) larva L3 puffstage 7-9  (152902) white prepupae new  (148036) white prepupae 12hr  (128782) white prepupae 24hr  (134762) pupae 2d postWPP  (106244) pupae 3d postWPP  (87306) pupae 4d postWPP  (102724) adult male 01day  (73387) adult male 05day  (76285) adult male 30day  (97715) adult female 01day  (195500) adult female 05day  (169688) adult female 30day  (185966) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (148693) embryo 02-04hr  (217897) embryo 04-06hr  (201418) embryo 06-08hr  (219772) embryo 08-10hr  (219251) embryo 10-12hr  (228335) embryo 12-14hr  (171318) embryo 14-16hr  (236368) embryo 16-18hr  (201467) embryo 18-20hr  (227851) embryo 20-22hr  (237807) embryo 22-24hr  (211842) larva L1  (296035) larva L2  (223489) larva L3 12hr old  (186985) larva L3 puffstage 1-2  (154186) larva L3 puffstage 3-6  (146508) larva L3 puffstage 7-9  (152902) white prepupae new  (148036) white prepupae 12hr  (128782) white prepupae 24hr  (134762) pupae 2d postWPP  (106244) pupae 3d postWPP  (87306) pupae 4d postWPP  (102724) adult male 01day  (73387) adult male 05day  (76285) adult male 30day  (97715) adult female 01day  (195500) adult female 05day  (169688) adult female 30day  (185966) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    148693 embryo 02-04hr    217897 embryo 04-06hr    201418 embryo 06-08hr    219772 embryo 08-10hr    219251 embryo 10-12hr    228335 embryo 12-14hr    171318 embryo 14-16hr    236368 embryo 16-18hr    201467 embryo 18-20hr    227851 embryo 20-22hr    237807 embryo 22-24hr    211842 larva L1    296035 larva L2    223489 larva L3 12hr old    186985 larva L3 puffstage 1-2    154186 larva L3 puffstage 3-6    146508 larva L3 puffstage 7-9    152902 white prepupae new    148036 white prepupae 12hr    128782 white prepupae 24hr    134762 pupae 2d postWPP    106244 pupae 3d postWPP    87306 pupae 4d postWPP    102724 adult male 01day    73387 adult male 05day    76285 adult male 30day    97715 adult female 01day    195500 adult female 05day    169688 adult female 30day    185966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010409    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010409 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010409 expression level Tissue   Expression Level Larval Central Nervous System    2903.15 Larval Midgut    5095.8 Larval Hindgut    4691.4 Larval Malpighian Tubules    5540.2 Larval Fat Body    8634 Larval Salivary Gland    8331.9 Larval Trachea    6487.65 Larval Carcass    5041.65 Adult Head    4952.5 Adult Eye    6548.175 Adult Brain    3080.7 Adult Thoracic-Abdominal Ganglion    4502.3 Adult Crop    6624.3 Adult Midgut    5497.5 Adult Hindgut    5388.3 Adult Malpighian Tubules    5135.5 Adult Fat Body    5905.4 Adult Salivary Gland    13984.3 Adult Heart    7147.15 Adult VirginFemale Spermatheca    5256.4 Adult InseminatedFemale Spermatheca    5329.4 Adult Ovary    3705.3 Adult Testis    1215.6 Adult Male Accessory Gland    10030.7 Adult Carcass    6389.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2903.15) Larval Midgut  (5095.8) Larval Hindgut  (4691.4) Larval Malpighian Tubules  (5540.2) Larval Fat Body  (8634) Larval Salivary Gland  (8331.9) Larval Trachea  (6487.65) Larval Carcass  (5041.65) Adult Head  (4952.5) Adult Eye  (6548.175) Adult Brain  (3080.7) Adult Thoracic-Abdominal Ganglion  (4502.3) Adult Crop  (6624.3) Adult Midgut  (5497.5) Adult Hindgut  (5388.3) Adult Malpighian Tubules  (5135.5) Adult Fat Body  (5905.4) Adult Salivary Gland  (13984.3) Adult Heart  (7147.15) Adult VirginFemale Spermatheca  (5256.4) Adult InseminatedFemale Spermatheca  (5329.4) Adult Ovary  (3705.3) Adult Testis  (1215.6) Adult Male Accessory Gland  (10030.7) Adult Carcass  (6389.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2903.15) Larval Midgut  (5095.8) Larval Hindgut  (4691.4) Larval Malpighian Tubules  (5540.2) Larval Fat Body  (8634) Larval Salivary Gland  (8331.9) Larval Trachea  (6487.65) Larval Carcass  (5041.65) Adult Head  (4952.5) Adult Eye  (6548.175) Adult Brain  (3080.7) Adult Thoracic-Abdominal Ganglion  (4502.3) Adult Crop  (6624.3) Adult Midgut  (5497.5) Adult Hindgut  (5388.3) Adult Malpighian Tubules  (5135.5) Adult Fat Body  (5905.4) Adult Salivary Gland  (13984.3) Adult Heart  (7147.15) Adult VirginFemale Spermatheca  (5256.4) Adult InseminatedFemale Spermatheca  (5329.4) Adult Ovary  (3705.3) Adult Testis  (1215.6) Adult Male Accessory Gland  (10030.7) Adult Carcass  (6389.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2903.15 Larval Midgut    5095.8 Larval Hindgut    4691.4 Larval Malpighian Tubules    5540.2 Larval Fat Body    8634 Larval Salivary Gland    8331.9 Larval Trachea    6487.65 Larval Carcass    5041.65 Adult Head    4952.5 Adult Eye    6548.175 Adult Brain    3080.7 Adult Thoracic-Abdominal Ganglion    4502.3 Adult Crop    6624.3 Adult Midgut    5497.5 Adult Hindgut    5388.3 Adult Malpighian Tubules    5135.5 Adult Fat Body    5905.4 Adult Salivary Gland    13984.3 Adult Heart    7147.15 Adult VirginFemale Spermatheca    5256.4 Adult InseminatedFemale Spermatheca    5329.4 Adult Ovary    3705.3 Adult Testis    1215.6 Adult Male Accessory Gland    10030.7 Adult Carcass    6389.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010409 expression level Tissue   Expression Level Larval Central Nervous System    2903.15 Larval Midgut    5095.8 Larval Hindgut    4691.4 Larval Malpighian Tubules    5540.2 Larval Fat Body    8634 Larval Salivary Gland    8331.9 Larval Trachea    6487.65 Larval Carcass    5041.65 Adult Head    4952.5 Adult Eye    6548.175 Adult Brain    3080.7 Adult Thoracic-Abdominal Ganglion    4502.3 Adult Crop    6624.3 Adult Midgut    5497.5 Adult Hindgut    5388.3 Adult Malpighian Tubules    5135.5 Adult Fat Body    5905.4 Adult Salivary Gland    13984.3 Adult Heart    7147.15 Adult VirginFemale Spermatheca    5256.4 Adult InseminatedFemale Spermatheca    5329.4 Adult Ovary    3705.3 Adult Testis    1215.6 Adult Male Accessory Gland    10030.7 Adult Carcass    6389.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2903.15) Larval Midgut  (5095.8) Larval Hindgut  (4691.4) Larval Malpighian Tubules  (5540.2) Larval Fat Body  (8634) Larval Salivary Gland  (8331.9) Larval Trachea  (6487.65) Larval Carcass  (5041.65) Adult Head  (4952.5) Adult Eye  (6548.175) Adult Brain  (3080.7) Adult Thoracic-Abdominal Ganglion  (4502.3) Adult Crop  (6624.3) Adult Midgut  (5497.5) Adult Hindgut  (5388.3) Adult Malpighian Tubules  (5135.5) Adult Fat Body  (5905.4) Adult Salivary Gland  (13984.3) Adult Heart  (7147.15) Adult VirginFemale Spermatheca  (5256.4) Adult InseminatedFemale Spermatheca  (5329.4) Adult Ovary  (3705.3) Adult Testis  (1215.6) Adult Male Accessory Gland  (10030.7) Adult Carcass  (6389.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2903.15) Larval Midgut  (5095.8) Larval Hindgut  (4691.4) Larval Malpighian Tubules  (5540.2) Larval Fat Body  (8634) Larval Salivary Gland  (8331.9) Larval Trachea  (6487.65) Larval Carcass  (5041.65) Adult Head  (4952.5) Adult Eye  (6548.175) Adult Brain  (3080.7) Adult Thoracic-Abdominal Ganglion  (4502.3) Adult Crop  (6624.3) Adult Midgut  (5497.5) Adult Hindgut  (5388.3) Adult Malpighian Tubules  (5135.5) Adult Fat Body  (5905.4) Adult Salivary Gland  (13984.3) Adult Heart  (7147.15) Adult VirginFemale Spermatheca  (5256.4) Adult InseminatedFemale Spermatheca  (5329.4) Adult Ovary  (3705.3) Adult Testis  1215.6 Adult Male Accessory Gland  (10030.7) Adult Carcass  (6389.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2903.15 Larval Midgut    5095.8 Larval Hindgut    4691.4 Larval Malpighian Tubules    5540.2 Larval Fat Body    8634 Larval Salivary Gland    8331.9 Larval Trachea    6487.65 Larval Carcass    5041.65 Adult Head    4952.5 Adult Eye    6548.175 Adult Brain    3080.7 Adult Thoracic-Abdominal Ganglion    4502.3 Adult Crop    6624.3 Adult Midgut    5497.5 Adult Hindgut    5388.3 Adult Malpighian Tubules    5135.5 Adult Fat Body    5905.4 Adult Salivary Gland    13984.3 Adult Heart    7147.15 Adult VirginFemale Spermatheca    5256.4 Adult InseminatedFemale Spermatheca    5329.4 Adult Ovary    3705.3 Adult Testis    1215.6 Adult Male Accessory Gland    10030.7 Adult Carcass    6389.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4952.5   NA  Eye    6548.175   NA  Brain    3080.7   2903.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4502.3   NA  Crop    6624.3   5095.8  Midgut    5497.5   4691.4  Hindgut    5388.3   5540.2  Malpighian Tubules    5135.5   8634  Fat Body    5905.4   8331.9  Salivary Gland    13984.3   NA  Heart    7147.15   6487.65  Trachea    NA   NA  VirginFemale Spermatheca    5256.4   NA  InseminatedFemale Spermatheca    5329.4   NA  Ovary    3705.3   NA  Testis    1215.6   NA  Male Accessory Gland    10030.7   5041.65  Carcass    6389.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_22
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010409 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6510-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of RpL18A Class Mutagen Stocks Known lesion RpL18AKG00567 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL18A Class Mutagen Stocks Known lesion RpL18AKK102557 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpL18AGD11944 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RpL18AGD16496 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11944} NA P{GD16496} NA P{KK102557} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}RpL18AKG00567 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome duplication inferred from mutant phenotype (Müller et al., 2010) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with UniProtKB:P11249 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with UniProtKB:P11249 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with UniProtKB:P11249 (FlyBase, 1992-) ribosome non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL18A allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62674 DroID - A comprehensive database of gene and protein interactions. • FBgn0010409 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36985
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13512 Dere\GG21044 Dgri\GH20961 Dmoj\GI21298 Dper\GL10622 Dpse\GA19650 Dsec\GM19972 Dsim\GD25466 Dvir\GJ20900 Dwil\GK21403 Dyak\RpL18A
Curated drosophilid orthologs	Dpse\GA19650   Dyak\RpL18A
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006785-PB Aedes aegypti (mosquito) AGAP012284-PA Anopheles gambiae (mosquito) XP_393322.1 Apis mellifera (honey bee) NP_001119646.1 Acyrthosiphon pisum (pea aphid) At1g29965.1 Arabidopsis thaliana (wall cress) At2g34480.1 Arabidopsis thaliana (wall cress) 17251 Batrachochytrium dendrobatidis (chytrid fungus) 116402 Branchiostoma floridae (lancelet) 287192 Branchiostoma floridae (lancelet) XP_001896063.1 Brugia malayi (roundworm nematode) BGIBMGA011467-PA Bombyx mori (silk worm) ENSBTAP00000021033 Bos taurus (bovine) CAL0003667 Candida albicans (a form of yeast) CN00062 Caenorhabditis brenneri (small nematode) CBP06076 Caenorhabditis briggsae (nematode) CE21392 Caenorhabditis elegans (worm) ENSCAFP00000022289 Canis familiaris (dog) CAGL0K07414g Candida glabrata (haploid yeast) Chro.70045 Cryptosporidium hominis (obligate parasite) ENSCINP00000024227 Ciona intestinalis (sea squirt) JA06306 Caenorhabditis japonica (nematode) CMO302C Cyanidioschyzon merolae (red alga) cn10191 Cryptococcus neoformans (yeast-like fungus) cgd7_320 Cryptosporidium parvum (protozoan parasite) CPIJ010528 Culex pipens (mosquito) ENSCPOP00000013706 Cavia porcellus (guinea pig) 146844 Chlamidomonas reinhardtii (green alga) RP25467 Caenorhabditis remanei (nematode) ENSCSAVP00000002931 Ciona savignyi (sedentary tunicate) 150312 Capitella spl (polychaete worm) DDB0233692 Dictyostelium discoideum (amoeba) DEHA2G02662g Debaryomyces Hansenii (yeast) 302788 Daphnia pulex (daphnia) ENSDARP00000038658 Danio rerio (zebra fish) ENSECAP00000012978 Equus caballus (horse) XP_648709 Entamoeba histolytica (anaerobic protozoan) XP_652609 Entamoeba histolytica (anaerobic protozoan) XP_653727 Entamoeba histolytica (anaerobic protozoan) XP_656136 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000764 Gymnopilus aculeatus (mushroom) ENSGALP00000015964 Gallus gallus (chicken) GL50803_16387 Giardia lamblia (flagellated protozoan) 110162 Hypsipyla robusta (cedar shoot borer) ENSP00000222247 Homo sapiens (human) ISCW010039-PA Ixodes scapularis (deer tick) KLLA0F08657g Kluyveromyces lactis (yeast) 207423 Lottia gigantea (owl limpet) LmjF32.0880 Leishmania major (virus) LmjF35.0600 Leishmania major (virus) ENSMODP00000023919 Monodelphis domestica (gray opossum) ENSMMUP00000031752 Macaca mulatta (rhesus monkey) ENSMUSP00000058368 Mus musculus (house mouse) 163400 Nematostella vectensis (starlet anemone) XP_001607320.1 Nasonia vitripennis (wasp) ENSOANP00000014531 Ornithorynchus anatinus (platypus) ENSORLP00000024964 Oryzias latipes (japanese killifish) LOC_Os01g47660.1 Oryza sativa (asian rice) LOC_Os01g54870.1 Oryza sativa (asian rice) LOC_Os05g49030.1 Oryza sativa (asian rice) 28526 Ostreococcus tauri (green alga) PF13_0224 Plasmodium falciparum (protozoal parasite) PHUM002270-PA Pediculus humanus (human body louse) PP12618 Pristionchus pacificus (nematode) 180633 Physcomitrella patens (moss) ENSPPYP00000010897 Pongo pygmaeus (orangutan) 78982 Phytophthora ramorum (sudden oak death pathogen) 85716 Phytophthora ramorum (sudden oak death pathogen) 135845 Phytophthora sojae (root rot pathogen) 813651 Populus trichocarpa (black cottonwood) ENSPTRP00000042855 Pan troglodytes (chimpanzee) PVX_082965 Plasmodium vivax (protozoal parasite) ENSRNOP00000025421 Rattus norvegicus (norway rat) 145052 Sorghum bicolor (sorghum) 148242 Sorghum bicolor (sorghum) 149821 Sorghum bicolor (sorghum) YMR242C Saccharomyces cerevisiae (budding yeast) YOR312C Saccharomyces cerevisiae (budding yeast) Smp_185810 Schistosoma mansoni (trematode parasite) SPAC26A3.04 Schizosaccharomyces pombe (fission yeast) SPAC3A12.10 Schizosaccharomyces pombe (fission yeast) XP_001190324.1 Strongylocentrotus purpuratus (purple sea urchin) 63193 Trichoplax adhaerens (metazoa) TA15210 Theileria annulata (apicomplexan parasite) XP_972907.1 Tribolium castaneum (red flour beetle) Tc00.1047053506957.90 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511001.120 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511727.129 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005032 Tetraodon nigroviridis (green spotted pufferfish) TP02_0803 Theileria parva (parasitic protozoan) 40329 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025729 Takifugu rubripes (pufferfish Takifugu) 3719.m00028 Tetrahymena thermophila (ciliate protozoa) 89034.m00124 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000046845 Xenopus tropicalis (frog) YALI0F24123g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15998 NV12000 NV11939 LH11652 ISCW010039 FBgn0068077 FBgn0223395 FBgn0208036 FBgn0196759 FBgn0174858 JGI_V11_302788 FBgn0079646 FBgn0148232 FBgn0144028 FBgn0128423 FBgn0113228 FBgn0090541 CPIJ010528 BGIBMGA011467 ACYPI000062 GB12795 AGAP012879 AGAP012284 AAEL006785 PHUM338970 GLEAN_04468
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	13681 y1 w67c23; P{SUPor-P}RpL18AKG00567
VDRC	v107278 P{KK102557}VIE-260B
Genomic Clones ( 1 )
	BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 862 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE26382
Other clones	yak-em_RpL18A
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13555 AT31138 GH01436 GH02249 GH05067 GH05293 GH06637 GH06652 GH09651 GH11194 GH14963 GH15258 GH16258 GH18118 GH18610 GH22809 GH27324 GM04741 GM10926 GM12934 GM14278 GM14439 GM15010 GM15752 GM17322 GM17372 GM17650 GM19027 GM19533 GM19537 GM19611 GM19724 GM20230 GM20545 GM21078 GM21494 GM22401 GM23473 GM23880 GM24040 GM24644 GM24730 GM26718 GM28541 GM29611 GM30043 GM31811 LD10309 LD21639 LD28042 LD33433 LD36795 LD39770 LD40379 LD41340 LD45483 LD47285 LP02032 LP03702 LP04565 LP05679 LP05940 LP06674 LP06905 LP09026 LP11286 LP11682 LP11935 LP13418 LP19048 LP20787 RE02171 RE07221 RE08392 RE08963 RE14626 RE20668 RE22808 RE26058 RE26488 RE31040 RE31282 RE40257 RE44410 RE44745 RE47973 RE48187 RE49265 RE49331 RE50187 RE51165 RE51231 RE60966 RE61771 RE62181 RE68668 RE69572 RH05282 RH08109 RH08265 RH10467 RH13529 RH14932 RH14991 RH15069 RH16075 RH17544 RH17889 RH18727 RH18948 RH40244 RH40814 RH41504 RH44392 RH45132 RH45571 RH47892 RH48867 RH52027 RH52233 RH54785 RH55738 RH55852 RH56535 RH56952 RH57520 RH62455 RH64624 RH65852 RH68171 RH70123 RH74108 RH74424 SD07583 SD11709 SD12406 SD12424 SD12430 SD12871 SD12989 SD13250 SD13438 SD13638 SD13978 SD13980 SD14242 SD14412 SD16359 SD16859 SD17649 SD18048 SD18759 SD19469 SD19821 SD21140 SD21172 SD21762 SD22174 SD22354 SD23440 SD25412 SD26708 SD27118 SD27273
Other clones	41825 55000 83419 105223 148365 153157 160520 191119 191243 191405 241151 275338 276923 473598 522078 522298 522334 522378 522909 522913 523074 523212 523249 523854 525641 533508 533864 533923 533931 557000 557753 561935 569576 569857 572785 572809 572895 AT31566 CK01.29D.D7 CK01.53D.F11 CK01.56D.G6 CK01.58D.B8 CK01.94C.F1 CK01.142A.B4 CK01.145B.C2 Dmel_dig_001520_0614_3688 Dmel_dig_001981_0715_0837 Dmel_dig_004826_0665_1936 Dmel_dig_008545_0624_1498 Dmel_dig_009820_0676_2700 Dmel_dig_011540_0627_3067 Dmel_dig_011573_0680_1112 Dmel_dig_012093_0646_1138 Dmel_dig_013501_0599_1049 Dmel_dig_014356_0685_2731 Dmel_dig_014683_0706_0995 Dmel_dig_014842_0623_1529 Dmel_dig_016861_0678_0637 Dmel_dig_017470_0673_1405 Dmel_dig_018071_0583_2873 Dmel_neb_004109_0656_0381 Dmel_neb_005295_0881_2463 Dmel_neb_005377_0444_3603 Dmel_neb_008710_0823_2754 Dmel_neb_009004_0615_1256 Dmel_neb_011158_0650_1391 Dmel_neb_011551_0096_2630 Dmel_neb_011945_0326_0871 Dmel_neb_012220_0842_1293 Dmel_neb_012765_0621_2955 Dmel_neb_013287_0133_2242 Dmel_neb_013626_0646_2677 Dmel_neb_013681_0943_1805 Dmel_neb_013913_0658_1520 Dmel_neb_014539_0934_3431 Dmel_neb_015186_0895_1376 Dmel_neb_016108_0911_2569 EC00834 EC00880 EC14866 EC24372 EC28534 EC28610 EC33323 EC35044 EC38513 EC40047 EK026310 EK047740 EK118538 EK155349 EK179302 EK181744 EK217738 EK254023 EK294122 EK302744 EN00325 EN00713 EN01329 EN01752 EN01837 EN01921 EN03017 EN03022 EN03349 EN03632 EN03714 EN04321 EN06134 EN06405 EN06846 EN09641 EN10319 EN12330 EN13419 EN15157 EN15741 EN17121 EN17338 ESG0111b.B21_E10 ESG0115b.B21_C01 ESG0116a.B21_E12 ESG0118a.B21_H08 FGA005C09 FGC013D09 FGC017A11 FGC017D06 FGC017F07 FGC017G04 FGC017H10 FGC021D04 FGC022H06 FGC024A12 FGC028D05 FGC030E07 FGC030E09 FGC031B09 FGH107F08 FGH112A12 FGH117G07 FGH122A12 FGH122C10 FGH123G10 FGM002E05 FGM004A09 FGM101B02 FGM101H07 FGM103B12 FGM207A11 FGM207H09 FGM210C03 FGM210E12 FGM211B07 FGM211C09 FGM211G11 FGM212F10 FGM217D09 FGM218F04 FGM220C02 FGM223A11 FGM223B03 FGM225H02 FGM228A04 FGM228H07 FGM228H10 FGM231D05 FGM233D02 FGM233H12 FGM236D02 FGM236D10 FGM301E10 FGM301F03 FGM301G08 FGM303H04 FGM308B10 FGM309C09 FGM309F11 FGM310F04 FGM310H01 FGM313H07 FGM319B09 FGM320G07 FGM321C10 FGM322B08 GH03346 GH05532 GH27320 GH28305 GM08408 GM13333 IP02077 IP02144 IP02505 IP02506 IP02507 IP02508 IP06759 IP08127 IP10029 IP10329 LD36670 LD42462 LD42575 LD43026 LD44574 LP03287 LP06388 LP09973 LP11435 LP12761 LP13171 LP18677 LP20508 LP21096 LP22221 RE01775 RE03366 RE03483 RE03514 RE04333 RE04674 RE07541 RE07990 RE09064 RE12125 RE12208 RE15489 RE16412 RE16833 RE17057 RE20918 RE21688 RE21828 RE27542 RE28383 RE29284 RE31536 RE31633 RE31838 RE33152 RE35367 RE35764 RE36135 RE36767 RE39314 RE40433 RE42358 RE44042 RE44318 RE44988 RE45047 RE46473 RE46776 RE47344 RE48065 RE48395 RE55733 RE57315 RE58865 RE59470 RE61043 RE62820 RE64517 RE64647 RE65155 RE68429 RE68694 RE69251 RE69837 RE70181 RE71530 RE72174 RE72483 RE74848 RH01596 RH01608 RH01784 RH01842 RH02033 RH02528 RH02546 RH02680 RH02881 RH03012 RH03122 RH03404 RH03516 RH03921 RH03984 RH04069 RH04340 RH04915 RH05232 RH05565 RH05662 RH06022 RH06048 RH07918 RH08228 RH08928 RH09550 RH10159 RH11429 RH12436 RH12783 RH12933 RH13443 RH16188 RH17484 RH18268 RH18472 RH19473 RH19474 RH20089 RH20554 RH20924 RH21888 RH23294 RH25661 RH26226 RH26340 RH27020 RH27039 RH27256 RH27309 RH27479 RH27922 RH29713 RH29831 RH31076 RH31117 RH31269 RH31282 RH31393 RH32595 RH33116 RH36810 RH38177 RH38201 RH38283 RH38392 RH38821 RH39108 RH39309 RH39628 RH39752 RH39805 RH40222 RH40706 RH41364 RH42119 RH42254 RH42911 RH43135 RH43520 RH43939 RH43995 RH44211 RH44376 RH44393 RH44463 RH45285 RH45417 RH46102 RH46881 RH47977 RH47988 RH49310 RH49523 RH50544 RH50977 RH51306 RH52064 RH52070 RH52094 RH52172 RH52312 RH52323 RH52590 RH52741 RH53261 RH53443 RH53828 RH54119 RH54134 RH55674 RH55724 RH56329 RH56724 RH57711 RH58639 RH58932 RH59887 RH60579 RH60837 RH61068 RH61328 RH61407 RH61668 RH61889 RH61977 RH62346 RH63328 RH63709 RH64240 RH64561 RH64994 RH65523 RH65727 RH66102 RH66502 RH66539 RH66689 RH66808 RH66844 RH67017 RH67301 RH68326 RH68524 RH69660 RH69966 RH69990 RH70314 RH70326 RH70614 RH71434 RH72179 RH72429 RH72988 RH73043 RH73744 RH73995 RH74146 RP003001794 RP003013729 RP003015697 RP003016095 RP003016740 RP003018496 RP003021197 RP003024500 RP003027584 RP003028282 RP003029671 RP003033630 RP003037126 RP003046171 RP003046273 RP003046536 RP003046828 RP003048914 RP003057265 RP003059955 RP003064486 RP003064837 RP003071410 RP003074693 RP003078955 RP003079618 RP003082085 RP003085698 RP003086150 RP003087400 RP003088475 RP003089789 RP003090721 RP003093571 RP003094608 RP003096627 RP003099745 RP003100923 RP003103081 RP003103385 RP003104247 RP003105112 RP003110629 RP003111144 RP003118490 RP003123248 RP003123703 RP003129003 RP003132153 RP003132860 RP003138001 RP003146125 RP003147090 RP003148433 RP003149817 RP003158371 RP003158538 RP003159479 RP003160763 RP003161596 RP003162366 RP003165310 RP003165971 RP003168916 RP003171655 RP003181099 RP003182195 RP003184129 RP003184320 RP003186710 RP003189501 RP003192234 RP003199539 RP003200051 RP003200283 RP003200895 RP003204182 RP003208527 RP003209577 RP003211559 RP003212851 RP003213809 RP003214260 RP003214665 RP003218771 RP003219316 RP003219931 RP003220057 RP003221423 RP003222495 RP003223449 RP003223553 RP003225523 RP003231955 RP003233239 RP003233648 RP003233722 RP003236491 RP003236548 RP003237253 RP003251495 RP003251715 RP003254074 RP003257336 RP003258125 RP003260373 RP003264782 RP003266789 RP003267206 RP003267505 RP003267618 RP003268014 RP003271536 RP003274529 RP003276605 RP003280279 RP003281731 RP003284391 RP003286994 RP003287278 RP003287392 RP003288260 RP003289870 RP003292000 RP003292888 RP003296099 RP003307314 RP003307576 RP003312251 RP003313601 RP003317576 RP003325002 RP003328001 RP003330770 RP003333084 RP003335230 RP003337593 RP003340205 RP003340278 RP003341469 RP003344286 RP003352379 RP003355100 RP003356572 RP003370320 RP003372537 RP003374736 RP003377680 RP003381616 RP003385115 RP003387802 RP003388521 RP003388711 RP003389060 RP003391052 RP003402898 RP003404218 RP003407835 RP003415473 RP003417672 RP003418852 RP003420180 RP003420385 RP003428424 RP003430878 RP003431220 RP003432510 RP003434732 RP003438412 RP003438496 RP003441210 RP003441589 RP003445664 RP003449651 RP003450260 RP003453632 RP003458405 RP003462042 RP003462517 RP003472721 RP003472934 RP003472995 RP003478813 RP003480138 RP003480145 RP003480498 RP003483263 RP003485175 RP003485419 RP003485739 RP003486495 RP003486534 RP003486639 RP003488307 RP003488824 RP003490567 RP003493096 RP003494410 RP003494717 RP003497303 RP003498675 RP003509726 RP003510222 RP003513636 RP003514343 RP003516465 RP003516611 RP003516633 RP003521277 RP003525834 RP003533137 RP003533243 RP003534351 RP003534646 RP003543593 RP003544021 RP003547563 RP003550073 RP003550529 RP003555733 RP003559734 RP003572333 RP003573932 RP003574901 RP003576036 RP003576462 RP003576606 RP003578711 RP003582822 RP003583703 RP003588062 RP003594848 RP003596163 RP003600550 RP003603042 RP003604185 RP003606469 RP003608268 RP003609028 RP003611441 RP003619204 RP003619603 RP003623400 RP003633385 RP003636281 RP003639153 RP003645468 RP003647690 RP003648564 RP003648920 RP003652192 RP003653218 RP003654438 RP003655905 RP003660392 RP003663894 RP003669974 RP003673251 RP003680931 UUGC0599 UUGC0820 UUGC0854
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010409 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36985
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Likely Minute gene. (Marygold et al., 2007) RpL18A lies in a gap in deletion coverage. (Marygold et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RpL18A is sequenced and expression pattern studied. (Ntwasa et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079050 RefSeq (Proteins) • NP_523774 DDBJ / EMBL / GenBank • AAF57838 AAL48844 AF083520 AY071222 BH759246 BI228745 CAA53089 X75339 Entrez Gene - A searchable database of RefSeq genes. • 36985 UniProtKB/Swiss-Prot • P41093
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L18a/LX (IPR023573) Ribosomal protein L18a (IPR021138)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62674 DroID - A comprehensive database of gene and protein interactions. • FBgn0010409 DRSC - Results from RNAi screens. • FBgn0010409 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010409 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6510-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010409 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36985 InParanoid A subset of ortholog calls from InParanoid. • AAEL006785-PB Aedes aegypti (mosquito) AGAP012284-PA Anopheles gambiae (mosquito) XP_393322.1 Apis mellifera (honey bee) NP_001119646.1 Acyrthosiphon pisum (pea aphid) At1g29965.1 Arabidopsis thaliana (wall cress) At2g34480.1 Arabidopsis thaliana (wall cress) 17251 Batrachochytrium dendrobatidis (chytrid fungus) 116402 Branchiostoma floridae (lancelet) 287192 Branchiostoma floridae (lancelet) XP_001896063.1 Brugia malayi (roundworm nematode) BGIBMGA011467-PA Bombyx mori (silk worm) ENSBTAP00000021033 Bos taurus (bovine) CAL0003667 Candida albicans (a form of yeast) CN00062 Caenorhabditis brenneri (small nematode) CBP06076 Caenorhabditis briggsae (nematode) CE21392 Caenorhabditis elegans (worm) ENSCAFP00000022289 Canis familiaris (dog) CAGL0K07414g Candida glabrata (haploid yeast) Chro.70045 Cryptosporidium hominis (obligate parasite) ENSCINP00000024227 Ciona intestinalis (sea squirt) JA06306 Caenorhabditis japonica (nematode) CMO302C Cyanidioschyzon merolae (red alga) cn10191 Cryptococcus neoformans (yeast-like fungus) cgd7_320 Cryptosporidium parvum (protozoan parasite) CPIJ010528 Culex pipens (mosquito) ENSCPOP00000013706 Cavia porcellus (guinea pig) 146844 Chlamidomonas reinhardtii (green alga) RP25467 Caenorhabditis remanei (nematode) ENSCSAVP00000002931 Ciona savignyi (sedentary tunicate) 150312 Capitella spl (polychaete worm) DDB0233692 Dictyostelium discoideum (amoeba) DEHA2G02662g Debaryomyces Hansenii (yeast) 302788 Daphnia pulex (daphnia) ENSDARP00000038658 Danio rerio (zebra fish) ENSECAP00000012978 Equus caballus (horse) XP_648709 Entamoeba histolytica (anaerobic protozoan) XP_652609 Entamoeba histolytica (anaerobic protozoan) XP_653727 Entamoeba histolytica (anaerobic protozoan) XP_656136 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000764 Gymnopilus aculeatus (mushroom) ENSGALP00000015964 Gallus gallus (chicken) GL50803_16387 Giardia lamblia (flagellated protozoan) 110162 Hypsipyla robusta (cedar shoot borer) ENSP00000222247 Homo sapiens (human) ISCW010039-PA Ixodes scapularis (deer tick) KLLA0F08657g Kluyveromyces lactis (yeast) 207423 Lottia gigantea (owl limpet) LmjF32.0880 Leishmania major (virus) LmjF35.0600 Leishmania major (virus) ENSMODP00000023919 Monodelphis domestica (gray opossum) ENSMMUP00000031752 Macaca mulatta (rhesus monkey) ENSMUSP00000058368 Mus musculus (house mouse) 163400 Nematostella vectensis (starlet anemone) XP_001607320.1 Nasonia vitripennis (wasp) ENSOANP00000014531 Ornithorynchus anatinus (platypus) ENSORLP00000024964 Oryzias latipes (japanese killifish) LOC_Os01g47660.1 Oryza sativa (asian rice) LOC_Os01g54870.1 Oryza sativa (asian rice) LOC_Os05g49030.1 Oryza sativa (asian rice) 28526 Ostreococcus tauri (green alga) PF13_0224 Plasmodium falciparum (protozoal parasite) PHUM002270-PA Pediculus humanus (human body louse) PP12618 Pristionchus pacificus (nematode) 180633 Physcomitrella patens (moss) ENSPPYP00000010897 Pongo pygmaeus (orangutan) 78982 Phytophthora ramorum (sudden oak death pathogen) 85716 Phytophthora ramorum (sudden oak death pathogen) 135845 Phytophthora sojae (root rot pathogen) 813651 Populus trichocarpa (black cottonwood) ENSPTRP00000042855 Pan troglodytes (chimpanzee) PVX_082965 Plasmodium vivax (protozoal parasite) ENSRNOP00000025421 Rattus norvegicus (norway rat) 145052 Sorghum bicolor (sorghum) 148242 Sorghum bicolor (sorghum) 149821 Sorghum bicolor (sorghum) YMR242C Saccharomyces cerevisiae (budding yeast) YOR312C Saccharomyces cerevisiae (budding yeast) Smp_185810 Schistosoma mansoni (trematode parasite) SPAC26A3.04 Schizosaccharomyces pombe (fission yeast) SPAC3A12.10 Schizosaccharomyces pombe (fission yeast) XP_001190324.1 Strongylocentrotus purpuratus (purple sea urchin) 63193 Trichoplax adhaerens (metazoa) TA15210 Theileria annulata (apicomplexan parasite) XP_972907.1 Tribolium castaneum (red flour beetle) Tc00.1047053506957.90 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511001.120 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511727.129 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005032 Tetraodon nigroviridis (green spotted pufferfish) TP02_0803 Theileria parva (parasitic protozoan) 40329 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025729 Takifugu rubripes (pufferfish Takifugu) 3719.m00028 Tetrahymena thermophila (ciliate protozoa) 89034.m00124 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000046845 Xenopus tropicalis (frog) YALI0F24123g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36985 modMine - Data generated by the modENCODE project. • FBgn0010409 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15998 NV12000 NV11939 LH11652 ISCW010039 FBgn0068077 FBgn0223395 FBgn0208036 FBgn0196759 FBgn0174858 JGI_V11_302788 FBgn0079646 FBgn0148232 FBgn0144028 FBgn0128423 FBgn0113228 FBgn0090541 CPIJ010528 BGIBMGA011467 ACYPI000062 GB12795 AGAP012879 AGAP012284 AAEL006785 PHUM338970 GLEAN_04468
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	anon-EST:Posey75   CG6510 (Goshima et al., 2007, Keleman et al., 2009.8.5, Marygold et al., 2007, Cammarato et al., 2011) L18 (Brogna et al., 2002) L18A (Molnar et al., 2003, Carpenter et al., 2009) L18a (Ntwasa et al., 1994) RpL18a   RpL18A (Wang et al., 2004, Goshima et al., 2007, Staudt et al., 2005, Nie et al., 2009, Marygold et al., 2007) RPL18a (Pinnola et al., 2007)
Name Synonym	ribosomal protein L18a (Gay, 1993.10.4, Ntwasa et al., 1994) Ribosomal protein L18A (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0025284
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Show all research papers ...