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FB2025_05
,
released December 11, 2025
S18
Please see the JBrowse view of Dmel\RpS18 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
0.7 (northern blot)
152 (aa); 18 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpS18 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
RpS18 transcripts are abundant and are detected throughout the life cycle.
JBrowse - Visual display of RNA-Seq signals
View Dmel\RpS18 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Likely Minute gene.
Deletions removing RpS18 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype with a low cell count when assayed in Kc167 cells.
An RpS18 cDNA has been cloned and sequenced.
A clone (λDmS18) containing a ribosomal protein gene that may encode an RPS18 protein has been identified. The clone hybridises in situ to 15B.
This may correspond to M(2)56F (FBrf0073138). Burns et al. (FBrf0041468) identified a clone that hybrid-selected an RNA that translated to give a protein identified as RPS18. The clone (λDmS18) hybridized in situ to 15B and these authors concluded that "M(1)o" (i.e. RpS5a) encoded this protein. McKim and Hawley ( EMBL:U48394 ) have shown, however, that RpS5a encodes RPS5; the status of the gene encoded by λDmS18 remains uncertain.
Source for merge of: RpS18 anon- EST:fe2D3
Source for merge of: RpS18 BcDNA:RH43343
Source for merge of: RpS18 anon-56Fa
"RpS18" likely corresponds to "M(2)56F".
Source for merge of RpS18 BcDNA:RH43343 was a shared cDNA ( date:030728 ).
Source for merge of RpS18 anon-56Fa was comparison of Figure 2. in FBrf0068407 with the corresponding region of the release 4.2 genome ( date:060307 ).
Source for identity of: RpS18 CG8900
