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Gene Dmel\RpS18

General Information
Symbol	Dmel\RpS18	Species	D. melanogaster
Name	Ribosomal protein S18	Annotation symbol	CG8900
Feature type	protein_coding_gene	FlyBase ID	FBgn0010411
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	S18
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	56F11-56F11	Sequence location	2R:16,151,477..16,152,353 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein S18 is referred to in FlyBase by the symbol Dmel\RpS18 (CG8900, FBgn0010411). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein S13; Ribosomal protein S13, conserved site; Ribosomal protein S13-like, H2TH. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624983_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of RpS18. Gene sequence location is 2R:16151477..16152353.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN21797 HFA07540
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56F11-56F11   Limits computationally determined from genome sequence between P{lacW}Ate1k10809 and P{EP}CG10444EP951
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56F-56F     (Garwood, 1993) 56F-56F   (determined by in situ hybridisation)   (Garwood and Lepesant, 1994) 56F-56F     (Axton et al., 1994)
Experimentally Determined Recombination Data
Location	2- (Axton et al., 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpS18 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpS18-RA FBtr0086274  NM_057616   631   152 RpS18-RB FBtr0086273  NM_166383   613   152
Additional Transcript Data & Comments
Reported size (kB)	0.7 (northern blot) (Garwood and Lepesant, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpS18-PA   FBpp0085586   17.6   152   11.17     NP_476964   AAF57491 RpS18-PB   FBpp0085585   17.6   152   11.17     NP_725943   AAM68401
Additional Polypeptide Data & Comments
Reported size (kDa)	152 (aa); 18 (kD predicted) (Garwood and Lepesant, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S13, conserved site (IPR018269) Ribosomal protein S13 (IPR001892) Ribosomal protein S13-like, H2TH (IPR010979)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201459   AA202712   AA246467   AA263430   AA263600   AA264145   AA264416   AA433253   AA539278   AA695475   AA695568   AA696080   AA696318   AA697050   AA697225   AA735918   AA802856   AA803223   AA816882   AA978532   AE013599 AAF57491   AE013599 AAM68401   AC004321   AF083275   AI113374   AI135096   AI238841   AI257353   AI257482   AI258727   AI260149   AI260561   AI260566   AI293907   AI295099   AI295509   AI297242   AI297390   AI386774   AI387737   AI388815   AI389273   AI403936   AI404512   AI405192   AI405854   AI406067   AI517591   AI534346   AY118434 AAM48463   AY167137 AAO17671   AY231741   AY232075   AY433510   AY440501   BE975116   BF489912   BF495386   BF499146   BG632427   BG633287   BG636134   BG638849   BG640670   BI163031   BI168733   BI170196   BI212451   BI216044   BI228912   BI231529   BI235864   BI241252   BI243601   BI351696   BI351700   BI352257   BI352379   BI352532   BI352881   BI353443   BI353554   BI354204   BI354487   BI354625   BI354664   BI354939   BI361731   BI361970   BI363143   BI363381   BI363391   BI363641   BI363676   BI363794   BI364964   BI365358   BI367572   BI370275   BI485064   BI563337   BI565428   BI565706   BI566720   BI566770   BI568359   BI568400   BI568428   BI570697   BI570698   BI571727   BI571779   BI572609   BI573105   BI574436   BI576316   BI577059   BI577079   BI577136   BI578853   BI580287   BI581282   BI584731   BI586772   BI586794   BI587870   BI588872   BI589355   BI589713   BI591711   BI591722   BI607441   BI608765   BI612127   BI613226   BI613284   BI613682   BI613707   BI614060   BI616290   BI616446   BI616872   BI618525   BI618724   BI619120   BI619598   BI620633   BI622081   BI623171   BI624261   BI624379   BI624444   BI625327   BI625873   BI627331   BI627572   BI630618   BI633572   BI634331   BI634643   BI634810   BI635502   BI637510   BI638295   BP541282   BP541289   BP541443   BP541591   BP541787   BP541889   BP542212   BP542351   BP542382   BP542403   BP542432   BP542447   BP542786   BP542946   BP543000   BP543270   BP543282   BP543466   BP543677   BP543744   BP543774   BP543834   BP543915   BP543949   BP544051   BP544054   BP544240   BP544264   BP544530   BP544549   BP544876   BP544916   BP545032   BP545285   BP545306   BP545330   BP545786   BP545794   BP545965   BP546277   BP546494   BP546771   BP547193   BP547351   BP547389   BP547627   BP547701   BP547755   BP547768   BP548203   BP548254   BP548296   BP548479   BP548568   BP548632   BP550728   BP551001   BP551541   BP551681   BP552720   BP552922   BP553951   BP553979   BP554322   BP554856   BP554878   BP555613   BP555785   BP555952   BP556558   BP558587   BT024929   BT050520   BX006616   BX009869   BX009940   BX016687   BX021615   BX021988   BX022521   BX023323   BX023986   BX026623   BX027156   BX027766   BX029852   BX030688   BX032189   BX032955   BX033110   BX033193   BX033669   BX034354   BX036585   BX036909   BX037394   BX037628   BX037930   BX038260   BX038637   BX038684   BX038793   BX038808   BX038897   BX042742   BX043249   BX047931   BX048447   BX049522   BX050031   BX063554   BX069062   BX072287   BX072310   BX072326   CA805660   CA805920   CA807212   CK605302   CK657287   CK657439   CK657466   CK658581   CK658615   CK658947   CK659233   CK660221   CK660688   CK660890   CK661574   CK661924   CK661938   CO153645   CO154082   CO154822   CO155381   CO155561   CO156344   CO156845   CO156879   CO156945   CO157043   CO180447   CO180525   CO182580   CO182629   CO184050   CO184220   CO184939   CO185156   CO191581   CO192168   CO293905   CO309154   CO314204   CO332929   CO335510   CO336036   CO336285   CO336321   CO336340   CO336575   CO337355   CO337584   CO337917   CO338140   CR937966   CZ468261   DQ440076   EC054829   EC069614   EC214126   EC235838   EC239809   EC248659   EC249657   EC261263   EC261283   EC261542   EC261600   EC262009   EC262124   EC262293   EC262771   EC262864   EC263252   EC263647   EC264176   EC264923   EC265215   EC265359   EC265492   EC265900   EC265915   EC265990   EC266887   EC267097   EC267508   EC268005   EL881093   EL881130   ES688807   ES689045   ES689609   ES689611   EV574831   EV574986   EV575307   EV575313   EV575764   EV576592   EV577031   EV579430   EV579479   EV579731   EV580946   EV582968   EV583829   EV584082   EV587622   EV587845   EV588115   EV589024   EV589976   EV591232   EV591367   EV592388   EV594795   EV597864   EV598751   GH755786   GH760126   GH760418   GH775706   GH776077   GH777751   GH785321   GH786236   GH792210   GH792416   GH798442   GH801547   GH801643   GH814097   GH814280   GH819185   GH821375   GH823768   GH832384   GH832416   GH833486   GH833514   GH834655   GH841983   GH844972   GH848005   GH853313   GH853508   GH854272   GH860799   GH861968   GH864526   GH865005   GH865601   GH866120   GH868519   GH868934   GH873260   GH873927   GH875014   GH875607   GH877331   GH877531   GH880907   GH884044   GH886314   GH888947   GH889449   GH892208   GH893559   GH897851   GH901286   GH901917   GH903975   GH912144   GH918049   GH919497   GH928557   GH929610   GH930614   GH931029   GH936601   GH936749   GH937007   GH937966   GH939748   GH940829   L22959 AAA28870
UniProtKB/Swiss-Prot	P41094
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Garwood and Lepesant, 1994)
Additional Descriptive Data
	RpS18 transcripts are abundant and are detected throughout the life cycle. (Garwood and Lepesant, 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010411    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010411 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010411 expression level Developmental Stage   Expression Level embryo 00-02hr    217685 embryo 02-04hr    303209 embryo 04-06hr    301276 embryo 06-08hr    328892 embryo 08-10hr    391902 embryo 10-12hr    599040 embryo 12-14hr    247485 embryo 14-16hr    417105 embryo 16-18hr    342024 embryo 18-20hr    278607 embryo 20-22hr    290675 embryo 22-24hr    236670 larva L1    391245 larva L2    267622 larva L3 12hr old    243609 larva L3 puffstage 1-2    216375 larva L3 puffstage 3-6    205373 larva L3 puffstage 7-9    212454 white prepupae new    163488 white prepupae 12hr    163934 white prepupae 24hr    151858 pupae 2d postWPP    127932 pupae 3d postWPP    105788 pupae 4d postWPP    163758 adult male 01day    96778 adult male 05day    105890 adult male 30day    150140 adult female 01day    295841 adult female 05day    205588 adult female 30day    222326 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (217685) embryo 02-04hr  (303209) embryo 04-06hr  (301276) embryo 06-08hr  (328892) embryo 08-10hr  (391902) embryo 10-12hr  (599040) embryo 12-14hr  (247485) embryo 14-16hr  (417105) embryo 16-18hr  (342024) embryo 18-20hr  (278607) embryo 20-22hr  (290675) embryo 22-24hr  (236670) larva L1  (391245) larva L2  (267622) larva L3 12hr old  (243609) larva L3 puffstage 1-2  (216375) larva L3 puffstage 3-6  (205373) larva L3 puffstage 7-9  (212454) white prepupae new  (163488) white prepupae 12hr  (163934) white prepupae 24hr  (151858) pupae 2d postWPP  (127932) pupae 3d postWPP  (105788) pupae 4d postWPP  (163758) adult male 01day  (96778) adult male 05day  (105890) adult male 30day  (150140) adult female 01day  (295841) adult female 05day  (205588) adult female 30day  (222326) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (217685) embryo 02-04hr  (303209) embryo 04-06hr  (301276) embryo 06-08hr  (328892) embryo 08-10hr  (391902) embryo 10-12hr  (599040) embryo 12-14hr  (247485) embryo 14-16hr  (417105) embryo 16-18hr  (342024) embryo 18-20hr  (278607) embryo 20-22hr  (290675) embryo 22-24hr  (236670) larva L1  (391245) larva L2  (267622) larva L3 12hr old  (243609) larva L3 puffstage 1-2  (216375) larva L3 puffstage 3-6  (205373) larva L3 puffstage 7-9  (212454) white prepupae new  (163488) white prepupae 12hr  (163934) white prepupae 24hr  (151858) pupae 2d postWPP  (127932) pupae 3d postWPP  (105788) pupae 4d postWPP  (163758) adult male 01day  (96778) adult male 05day  (105890) adult male 30day  (150140) adult female 01day  (295841) adult female 05day  (205588) adult female 30day  (222326) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (217685) embryo 02-04hr  (303209) embryo 04-06hr  (301276) embryo 06-08hr  (328892) embryo 08-10hr  (391902) embryo 10-12hr  (599040) embryo 12-14hr  (247485) embryo 14-16hr  (417105) embryo 16-18hr  (342024) embryo 18-20hr  (278607) embryo 20-22hr  (290675) embryo 22-24hr  (236670) larva L1  (391245) larva L2  (267622) larva L3 12hr old  (243609) larva L3 puffstage 1-2  (216375) larva L3 puffstage 3-6  (205373) larva L3 puffstage 7-9  (212454) white prepupae new  (163488) white prepupae 12hr  (163934) white prepupae 24hr  (151858) pupae 2d postWPP  (127932) pupae 3d postWPP  (105788) pupae 4d postWPP  (163758) adult male 01day  (96778) adult male 05day  (105890) adult male 30day  (150140) adult female 01day  (295841) adult female 05day  (205588) adult female 30day  (222326) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    217685 embryo 02-04hr    303209 embryo 04-06hr    301276 embryo 06-08hr    328892 embryo 08-10hr    391902 embryo 10-12hr    599040 embryo 12-14hr    247485 embryo 14-16hr    417105 embryo 16-18hr    342024 embryo 18-20hr    278607 embryo 20-22hr    290675 embryo 22-24hr    236670 larva L1    391245 larva L2    267622 larva L3 12hr old    243609 larva L3 puffstage 1-2    216375 larva L3 puffstage 3-6    205373 larva L3 puffstage 7-9    212454 white prepupae new    163488 white prepupae 12hr    163934 white prepupae 24hr    151858 pupae 2d postWPP    127932 pupae 3d postWPP    105788 pupae 4d postWPP    163758 adult male 01day    96778 adult male 05day    105890 adult male 30day    150140 adult female 01day    295841 adult female 05day    205588 adult female 30day    222326 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010411 expression level Developmental Stage   Expression Level embryo 00-02hr    217685 embryo 02-04hr    303209 embryo 04-06hr    301276 embryo 06-08hr    328892 embryo 08-10hr    391902 embryo 10-12hr    599040 embryo 12-14hr    247485 embryo 14-16hr    417105 embryo 16-18hr    342024 embryo 18-20hr    278607 embryo 20-22hr    290675 embryo 22-24hr    236670 larva L1    391245 larva L2    267622 larva L3 12hr old    243609 larva L3 puffstage 1-2    216375 larva L3 puffstage 3-6    205373 larva L3 puffstage 7-9    212454 white prepupae new    163488 white prepupae 12hr    163934 white prepupae 24hr    151858 pupae 2d postWPP    127932 pupae 3d postWPP    105788 pupae 4d postWPP    163758 adult male 01day    96778 adult male 05day    105890 adult male 30day    150140 adult female 01day    295841 adult female 05day    205588 adult female 30day    222326 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (217685) embryo 02-04hr  (303209) embryo 04-06hr  (301276) embryo 06-08hr  (328892) embryo 08-10hr  (391902) embryo 10-12hr  (599040) embryo 12-14hr  (247485) embryo 14-16hr  (417105) embryo 16-18hr  (342024) embryo 18-20hr  (278607) embryo 20-22hr  (290675) embryo 22-24hr  (236670) larva L1  (391245) larva L2  (267622) larva L3 12hr old  (243609) larva L3 puffstage 1-2  (216375) larva L3 puffstage 3-6  (205373) larva L3 puffstage 7-9  (212454) white prepupae new  (163488) white prepupae 12hr  (163934) white prepupae 24hr  (151858) pupae 2d postWPP  (127932) pupae 3d postWPP  (105788) pupae 4d postWPP  (163758) adult male 01day  (96778) adult male 05day  (105890) adult male 30day  (150140) adult female 01day  (295841) adult female 05day  (205588) adult female 30day  (222326) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (217685) embryo 02-04hr  (303209) embryo 04-06hr  (301276) embryo 06-08hr  (328892) embryo 08-10hr  (391902) embryo 10-12hr  (599040) embryo 12-14hr  (247485) embryo 14-16hr  (417105) embryo 16-18hr  (342024) embryo 18-20hr  (278607) embryo 20-22hr  (290675) embryo 22-24hr  (236670) larva L1  (391245) larva L2  (267622) larva L3 12hr old  (243609) larva L3 puffstage 1-2  (216375) larva L3 puffstage 3-6  (205373) larva L3 puffstage 7-9  (212454) white prepupae new  (163488) white prepupae 12hr  (163934) white prepupae 24hr  (151858) pupae 2d postWPP  (127932) pupae 3d postWPP  (105788) pupae 4d postWPP  (163758) adult male 01day  (96778) adult male 05day  (105890) adult male 30day  (150140) adult female 01day  (295841) adult female 05day  (205588) adult female 30day  (222326) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (217685) embryo 02-04hr  (303209) embryo 04-06hr  (301276) embryo 06-08hr  (328892) embryo 08-10hr  (391902) embryo 10-12hr  (599040) embryo 12-14hr  (247485) embryo 14-16hr  (417105) embryo 16-18hr  (342024) embryo 18-20hr  (278607) embryo 20-22hr  (290675) embryo 22-24hr  (236670) larva L1  (391245) larva L2  (267622) larva L3 12hr old  (243609) larva L3 puffstage 1-2  (216375) larva L3 puffstage 3-6  (205373) larva L3 puffstage 7-9  (212454) white prepupae new  (163488) white prepupae 12hr  (163934) white prepupae 24hr  (151858) pupae 2d postWPP  (127932) pupae 3d postWPP  (105788) pupae 4d postWPP  (163758) adult male 01day  (96778) adult male 05day  (105890) adult male 30day  (150140) adult female 01day  (295841) adult female 05day  (205588) adult female 30day  (222326) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    217685 embryo 02-04hr    303209 embryo 04-06hr    301276 embryo 06-08hr    328892 embryo 08-10hr    391902 embryo 10-12hr    599040 embryo 12-14hr    247485 embryo 14-16hr    417105 embryo 16-18hr    342024 embryo 18-20hr    278607 embryo 20-22hr    290675 embryo 22-24hr    236670 larva L1    391245 larva L2    267622 larva L3 12hr old    243609 larva L3 puffstage 1-2    216375 larva L3 puffstage 3-6    205373 larva L3 puffstage 7-9    212454 white prepupae new    163488 white prepupae 12hr    163934 white prepupae 24hr    151858 pupae 2d postWPP    127932 pupae 3d postWPP    105788 pupae 4d postWPP    163758 adult male 01day    96778 adult male 05day    105890 adult male 30day    150140 adult female 01day    295841 adult female 05day    205588 adult female 30day    222326 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010411    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010411 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010411 expression level Tissue   Expression Level Larval Central Nervous System    3219.425 Larval Midgut    5709.9 Larval Hindgut    5256 Larval Malpighian Tubules    5971.8 Larval Fat Body    9383.7 Larval Salivary Gland    9119.5 Larval Trachea    6529.725 Larval Carcass    5476.675 Adult Head    5510.4 Adult Eye    6709.525 Adult Brain    3511.2 Adult Thoracic-Abdominal Ganglion    4691.5 Adult Crop    7289.2 Adult Midgut    6473.4 Adult Hindgut    5913.5 Adult Malpighian Tubules    2304.6 Adult Fat Body    6695.5 Adult Salivary Gland    12935.1 Adult Heart    7359.975 Adult VirginFemale Spermatheca    4497.4 Adult InseminatedFemale Spermatheca    4475.6 Adult Ovary    4037.4 Adult Testis    1413.9 Adult Male Accessory Gland    10287.1 Adult Carcass    6511.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3219.425) Larval Midgut  (5709.9) Larval Hindgut  (5256) Larval Malpighian Tubules  (5971.8) Larval Fat Body  (9383.7) Larval Salivary Gland  (9119.5) Larval Trachea  (6529.725) Larval Carcass  (5476.675) Adult Head  (5510.4) Adult Eye  (6709.525) Adult Brain  (3511.2) Adult Thoracic-Abdominal Ganglion  (4691.5) Adult Crop  (7289.2) Adult Midgut  (6473.4) Adult Hindgut  (5913.5) Adult Malpighian Tubules  (2304.6) Adult Fat Body  (6695.5) Adult Salivary Gland  (12935.1) Adult Heart  (7359.975) Adult VirginFemale Spermatheca  (4497.4) Adult InseminatedFemale Spermatheca  (4475.6) Adult Ovary  (4037.4) Adult Testis  (1413.9) Adult Male Accessory Gland  (10287.1) Adult Carcass  (6511.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3219.425) Larval Midgut  (5709.9) Larval Hindgut  (5256) Larval Malpighian Tubules  (5971.8) Larval Fat Body  (9383.7) Larval Salivary Gland  (9119.5) Larval Trachea  (6529.725) Larval Carcass  (5476.675) Adult Head  (5510.4) Adult Eye  (6709.525) Adult Brain  (3511.2) Adult Thoracic-Abdominal Ganglion  (4691.5) Adult Crop  (7289.2) Adult Midgut  (6473.4) Adult Hindgut  (5913.5) Adult Malpighian Tubules  (2304.6) Adult Fat Body  (6695.5) Adult Salivary Gland  (12935.1) Adult Heart  (7359.975) Adult VirginFemale Spermatheca  (4497.4) Adult InseminatedFemale Spermatheca  (4475.6) Adult Ovary  (4037.4) Adult Testis  (1413.9) Adult Male Accessory Gland  (10287.1) Adult Carcass  (6511.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3219.425 Larval Midgut    5709.9 Larval Hindgut    5256 Larval Malpighian Tubules    5971.8 Larval Fat Body    9383.7 Larval Salivary Gland    9119.5 Larval Trachea    6529.725 Larval Carcass    5476.675 Adult Head    5510.4 Adult Eye    6709.525 Adult Brain    3511.2 Adult Thoracic-Abdominal Ganglion    4691.5 Adult Crop    7289.2 Adult Midgut    6473.4 Adult Hindgut    5913.5 Adult Malpighian Tubules    2304.6 Adult Fat Body    6695.5 Adult Salivary Gland    12935.1 Adult Heart    7359.975 Adult VirginFemale Spermatheca    4497.4 Adult InseminatedFemale Spermatheca    4475.6 Adult Ovary    4037.4 Adult Testis    1413.9 Adult Male Accessory Gland    10287.1 Adult Carcass    6511.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010411 expression level Tissue   Expression Level Larval Central Nervous System    3219.425 Larval Midgut    5709.9 Larval Hindgut    5256 Larval Malpighian Tubules    5971.8 Larval Fat Body    9383.7 Larval Salivary Gland    9119.5 Larval Trachea    6529.725 Larval Carcass    5476.675 Adult Head    5510.4 Adult Eye    6709.525 Adult Brain    3511.2 Adult Thoracic-Abdominal Ganglion    4691.5 Adult Crop    7289.2 Adult Midgut    6473.4 Adult Hindgut    5913.5 Adult Malpighian Tubules    2304.6 Adult Fat Body    6695.5 Adult Salivary Gland    12935.1 Adult Heart    7359.975 Adult VirginFemale Spermatheca    4497.4 Adult InseminatedFemale Spermatheca    4475.6 Adult Ovary    4037.4 Adult Testis    1413.9 Adult Male Accessory Gland    10287.1 Adult Carcass    6511.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3219.425) Larval Midgut  (5709.9) Larval Hindgut  (5256) Larval Malpighian Tubules  (5971.8) Larval Fat Body  (9383.7) Larval Salivary Gland  (9119.5) Larval Trachea  (6529.725) Larval Carcass  (5476.675) Adult Head  (5510.4) Adult Eye  (6709.525) Adult Brain  (3511.2) Adult Thoracic-Abdominal Ganglion  (4691.5) Adult Crop  (7289.2) Adult Midgut  (6473.4) Adult Hindgut  (5913.5) Adult Malpighian Tubules  (2304.6) Adult Fat Body  (6695.5) Adult Salivary Gland  (12935.1) Adult Heart  (7359.975) Adult VirginFemale Spermatheca  (4497.4) Adult InseminatedFemale Spermatheca  (4475.6) Adult Ovary  (4037.4) Adult Testis  (1413.9) Adult Male Accessory Gland  (10287.1) Adult Carcass  (6511.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3219.425) Larval Midgut  (5709.9) Larval Hindgut  (5256) Larval Malpighian Tubules  (5971.8) Larval Fat Body  (9383.7) Larval Salivary Gland  (9119.5) Larval Trachea  (6529.725) Larval Carcass  (5476.675) Adult Head  (5510.4) Adult Eye  (6709.525) Adult Brain  (3511.2) Adult Thoracic-Abdominal Ganglion  (4691.5) Adult Crop  (7289.2) Adult Midgut  (6473.4) Adult Hindgut  (5913.5) Adult Malpighian Tubules  (2304.6) Adult Fat Body  (6695.5) Adult Salivary Gland  (12935.1) Adult Heart  (7359.975) Adult VirginFemale Spermatheca  (4497.4) Adult InseminatedFemale Spermatheca  (4475.6) Adult Ovary  (4037.4) Adult Testis  1413.9 Adult Male Accessory Gland  (10287.1) Adult Carcass  (6511.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3219.425 Larval Midgut    5709.9 Larval Hindgut    5256 Larval Malpighian Tubules    5971.8 Larval Fat Body    9383.7 Larval Salivary Gland    9119.5 Larval Trachea    6529.725 Larval Carcass    5476.675 Adult Head    5510.4 Adult Eye    6709.525 Adult Brain    3511.2 Adult Thoracic-Abdominal Ganglion    4691.5 Adult Crop    7289.2 Adult Midgut    6473.4 Adult Hindgut    5913.5 Adult Malpighian Tubules    2304.6 Adult Fat Body    6695.5 Adult Salivary Gland    12935.1 Adult Heart    7359.975 Adult VirginFemale Spermatheca    4497.4 Adult InseminatedFemale Spermatheca    4475.6 Adult Ovary    4037.4 Adult Testis    1413.9 Adult Male Accessory Gland    10287.1 Adult Carcass    6511.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5510.4   NA  Eye    6709.525   NA  Brain    3511.2   3219.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4691.5   NA  Crop    7289.2   5709.9  Midgut    6473.4   5256  Hindgut    5913.5   5971.8  Malpighian Tubules    2304.6   9383.7  Fat Body    6695.5   9119.5  Salivary Gland    12935.1   NA  Heart    7359.975   6529.725  Trachea    NA   NA  VirginFemale Spermatheca    4497.4   NA  InseminatedFemale Spermatheca    4475.6   NA  Ovary    4037.4   NA  Testis    1413.9   NA  Male Accessory Gland    10287.1   5476.675  Carcass    6511.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_22
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010411 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8900-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 RpS18GD12535 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of RpS18 Class Mutagen Stocks Known lesion RpS18c02853 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpS18 Class Mutagen Stocks Known lesion RpS18GD12535 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpS18KK101746 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)173 (Axton et al., 1994) Df(2R)Exel7162 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12535} NA P{KK101746} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}RpS18c02853 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR001892, InterPro:IPR018269 (FlyBase Curators et al., 2004-) structural constituent of ribosome inferred from sequence or structural similarity with Saccharomyces RPS18A (FlyBase, 1992-) non-traceable author statement (Garwood, 1993, Swiss-Prot Project Members, 1995.2.1)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with Saccharomyces RPS18A (FlyBase, 1992-) non-traceable author statement (Garwood, 1993) translational initiation non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Cellular Component
CV term Evidence References
cytosolic small ribosomal subunit inferred from sequence or structural similarity with Saccharomyces RPS18A (FlyBase, 1992-) non-traceable author statement (Garwood, 1993) ribosome non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpS18 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62947 DroID - A comprehensive database of gene and protein interactions. • FBgn0010411 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37292
Orthologs
Genome-wide drosophilid orthologs	Dana\RpS18 Dere\RpS18 Dgri\GH23036 Dmoj\GI21106 Dper\GL16906 Dpse\GA21399 Dsec\RpS18 Dsim\RpS18 Dvir\RpS18 Dwil\RpS18 Dyak\RpS18
Curated drosophilid orthologs	Dana\RpS18   Dere\RpS18   Dfun\RpS18   Dhyd\RpS18   Dmau\RpS18   Dmer\RpS18   Dpse\GA21399   Dsal\RpS18   Dsec\RpS18   Dsim\RpS18   Dvir\RpS18   Dwil\RpS18   Dyak\RpS18
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009747-PA Aedes aegypti (mosquito) AGAP010375-PA Anopheles gambiae (mosquito) XP_625104.1 Apis mellifera (honey bee) NP_001119689.1 Acyrthosiphon pisum (pea aphid) At1g22780.1 Arabidopsis thaliana (wall cress) At1g34030.1 Arabidopsis thaliana (wall cress) At4g09800.1 Arabidopsis thaliana (wall cress) 91663 Batrachochytrium dendrobatidis (chytrid fungus) 114927 Branchiostoma floridae (lancelet) 124370 Branchiostoma floridae (lancelet) XP_001900844.1 Brugia malayi (roundworm nematode) BGIBMGA003197-PA Bombyx mori (silk worm) ENSBTAP00000003431 Bos taurus (bovine) CAL0001937 Candida albicans (a form of yeast) CBP05102 Caenorhabditis briggsae (nematode) CE14956 Caenorhabditis elegans (worm) ENSCAFP00000001357 Canis familiaris (dog) CAGL0G07227g Candida glabrata (haploid yeast) Chro.30283 Cryptosporidium hominis (obligate parasite) JA05976 Caenorhabditis japonica (nematode) CMB004C Cyanidioschyzon merolae (red alga) cn10042 Cryptococcus neoformans (yeast-like fungus) cgd3_2440 Cryptosporidium parvum (protozoan parasite) CPIJ014165 Culex pipens (mosquito) ENSCPOP00000017778 Cavia porcellus (guinea pig) 155649 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000008974 Ciona savignyi (sedentary tunicate) 228718 Capitella spl (polychaete worm) DDB0231058 Dictyostelium discoideum (amoeba) DEHA2F22308g Debaryomyces Hansenii (yeast) 300691 Daphnia pulex (daphnia) ENSDARP00000005719 Danio rerio (zebra fish) ENSECAP00000013663 Equus caballus (horse) NP_417757.1 Escherichia coli K12 (bacteria) XP_653090 Entamoeba histolytica (anaerobic protozoan) XP_654098 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012973 Gymnopilus aculeatus (mushroom) GL50803_15551 Giardia lamblia (flagellated protozoan) 157357 Hypsipyla robusta (cedar shoot borer) ENSP00000211372 Homo sapiens (human) ENSP00000363762 Homo sapiens (human) ENSP00000372554 Homo sapiens (human) KLLA0B01562g Kluyveromyces lactis (yeast) 198613 Lottia gigantea (owl limpet) LmjF36.0930 Leishmania major (virus) LmjF36.0940 Leishmania major (virus) 37988 Monocosta brevicollis (choanoflagellate) ENSMODP00000017765 Monodelphis domestica (gray opossum) ENSMMUP00000019224 Macaca mulatta (rhesus monkey) ENSMUSP00000008812 Mus musculus (house mouse) ENSMUSP00000079301 Mus musculus (house mouse) 245261 Nematostella vectensis (starlet anemone) XP_001601390.1 Nasonia vitripennis (wasp) ENSORLP00000001372 Oryzias latipes (japanese killifish) LOC_Os03g58050.1 Oryza sativa (asian rice) LOC_Os07g07709.1 Oryza sativa (asian rice) 29470 Ostreococcus tauri (green alga) PF11_0272 Plasmodium falciparum (protozoal parasite) PHUM001770-PA Pediculus humanus (human body louse) PP26087 Pristionchus pacificus (nematode) 175952 Physcomitrella patens (moss) 175960 Physcomitrella patens (moss) 184305 Physcomitrella patens (moss) 194376 Physcomitrella patens (moss) 195584 Physcomitrella patens (moss) 221618 Physcomitrella patens (moss) ENSPPYP00000023575 Pongo pygmaeus (orangutan) 47000 Phytophthora ramorum (sudden oak death pathogen) 108718 Phytophthora sojae (root rot pathogen) 551159 Populus trichocarpa (black cottonwood) 559569 Populus trichocarpa (black cottonwood) ENSPTRP00000030810 Pan troglodytes (chimpanzee) PVX_091925 Plasmodium vivax (protozoal parasite) ENSRNOP00000030371 Rattus norvegicus (norway rat) ENSRNOP00000047371 Rattus norvegicus (norway rat) 5047969 Sorghum bicolor (sorghum) YDR450W Saccharomyces cerevisiae (budding yeast) YML026C Saccharomyces cerevisiae (budding yeast) Smp_074780 Schistosoma mansoni (trematode parasite) SPBC16D10.11c Schizosaccharomyces pombe (fission yeast) SPCC1259.01c Schizosaccharomyces pombe (fission yeast) XP_001202116.1 Strongylocentrotus purpuratus (purple sea urchin) XP_794924.1 Strongylocentrotus purpuratus (purple sea urchin) 35456 Trichoplax adhaerens (metazoa) TA21115 Theileria annulata (apicomplexan parasite) XP_973632.1 Tribolium castaneum (red flour beetle) Tc00.1047053506679.100 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506679.94 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005526 Tetraodon nigroviridis (green spotted pufferfish) TP01_0351 Theileria parva (parasitic protozoan) 26893 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034159 Takifugu rubripes (pufferfish Takifugu) 3698.m00005 Tetrahymena thermophila (ciliate protozoa) 80898.m00101 Trichomonas vaginalis (parasitic flagellated protozoan) 81840.m00180 Trichomonas vaginalis (parasitic flagellated protozoan) 82437.m00006 Trichomonas vaginalis (parasitic flagellated protozoan) 86492.m00163 Trichomonas vaginalis (parasitic flagellated protozoan) 92069.m00272 Trichomonas vaginalis (parasitic flagellated protozoan) 94736.m00070 Trichomonas vaginalis (parasitic flagellated protozoan) 97119.m00162 Trichomonas vaginalis (parasitic flagellated protozoan) 97121.m00165 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000044004 Xenopus tropicalis (frog) YALI0D20614g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17400 LH15218 ISCW015565 FBgn0064254 FBgn0064271 FBgn0064312 FBgn0064360 FBgn0064375 JGI_V11_300691 FBgn0081386 FBgn0154510 FBgn0143838 FBgn0130493 FBgn0064610 FBgn0099717 FBgn0064749 CPIJ014165 BGIBMGA003197 ACYPI000081 GB12140 AGAP010375 AAEL009747 PB23085 PHUM463880 GLEAN_14405
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v23083 w1118; P{GD12535}v23083
Genomic Clones ( 1 )
	BACR48L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 404 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP16603 RH43343
Other clones	FI09342 yak-ad_RpS18 yak-em_RpS18
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04222 AT13649 AT26103 GH08208 GH08350 GH14965 GH18374 GH19836 GH20408 GH23487 GH23663 GH24253 GH25127 GH26001 GH26253 GH28612 GM02884 GM03040 GM05027 GM06433 GM07448 GM09010 GM09468 GM10104 GM10422 GM15737 GM15749 GM18541 GM19025 GM19682 GM21155 GM23643 GM24152 GM26812 GM27010 GM27649 GM27793 GM28975 LD02936 LD04477 LD06962 LD07705 LD08167 LD18962 LD20067 LD30780 LD37809 LP01988 LP03845 LP04472 LP04479 LP05685 LP05866 LP07166 LP08630 LP09168 LP11506 LP11679 LP15595 LP15680 LP16289 LP16855 LP18589 LP19480 LP19840 LP21172 LP21763 LP23469 LP23742 RE02326 RE09583 RE11575 RE17546 RE22405 RE22847 RE26572 RE31814 RE41289 RE46069 RE46413 RE47885 RE48172 RE48184 RE48544 RE48741 RE50172 RE50641 RE53365 RE68333 RE70779 RE72784 RE74457 RH03185 RH06581 RH06592 RH13458 RH18652 RH23995 RH26870 RH26893 RH28766 RH30320 RH31778 RH33926 RH33947 RH33957 RH38068 RH38840 RH40529 RH42337 RH42889 RH46984 RH49378 RH49613 RH50092 RH50666 RH51822 RH53896 RH55268 RH59894 RH63791 RH63930 RH64006 RH65669 RH74513 SD07146 SD11809 SD13732 SD16870 SD19549 SD20547 SD27692 UT01825
Other clones	75122 108541 108737 157212 280546 522358 522649 523118 524160 524795 524995 527755 528301 533496 533593 542439 542586 556923 557698 557735 557755 558003 569008 569264 569775 569989 571321 575667 AA433253 bs38g07 CK01.67B.D2 Dmel_dig_005223_0616_3746 Dmel_dig_006316_0669_1390 Dmel_dig_007378_0602_0871 Dmel_dig_008498_0641_0426 Dmel_dig_012144_0626_1238 Dmel_dig_012323_0659_2346 Dmel_dig_013707_0592_1477 Dmel_dig_016467_0696_0840 Dmel_dig_017355_0613_1711 Dmel_dig_018149_0689_1996 Dmel_dig_019016_0587_1234 Dmel_dig_019302_0611_3284 Dmel_dig_020688_0583_3001 Dmel_dig_020834_0610_0710 Dmel_neb_004300_0124_3671 Dmel_neb_004786_0903_0360 Dmel_neb_005945_0596_0834 Dmel_neb_010161_0381_0404 Dmel_neb_010772_0133_3106 Dmel_neb_011020_0826_1022 Dmel_neb_012840_0165_0737 Dmel_neb_013473_0679_3208 Dmel_neb_013692_0421_3080 Dmel_neb_013951_0179_0572 Dmel_neb_014217_0387_2455 EC01565 EC02006 EC22994 EC23440 EC27006 EC27385 EC28835 EC29740 EC31444 EC33283 EC054829 EK205061 EK235420 EK260455 EK305155 EN02511 EN03444 EN04855 EN05939 EN06324 EN07862 EN09425 EN09503 EN09627 EN09826 EN10619 EN11711 EN12224 EN12313 EN12333 EN12815 EN14342 EN14846 EN15563 EN16029 ESG016d.E21_E02 ESG0119a.B21_F01 ESG0120b.B21_D03 FGB001C05 FGB001C12 FGC001F11 FGC003C09 FGC005D07 FGC006F07 FGC010D01 FGC012B12 FGC012E08 FGC012G07 FGC013B02 FGC013C06 FGC016H12 FGC017G10 FGC018B02 FGC019E11 FGC019F05 FGC020F04 FGC021G08 FGC022B06 FGC022C09 FGC022F06 FGC023A11 FGC023C06 FGC023G10 FGC023G12 FGC024G11 FGC024H11 FGC026D04 FGC026E02 FGC028C06 FGC028E04 FGC029B04 FGC030E01 FGC030E12 FGC030F12 FGC033E07 FGC033F03 FGH101D08 FGH104F10 FGH107A06 FGH109H11 FGH114D07 FGH116A09 FGH116D11 FGH119A03 FGH119G09 FGH120D03 FGH120E04 FGH125B02 FGH125F07 FGH126B03 FGH128C02 FGH129B07 FGH129H03 FGM208G07 FGM210D06 FGM213D12 FGM214B12 FGM220D05 FGM221E11 FGM227B11 FGM227D01 FGM229C02 FGM232B01 FGM232B12 FGM236B12 FGM237B05 FGM238B05 FGM304C01 FGM315H03 GH12729 GH16982 IP10905 IP10935 LD05626 LD07218 LP21735 LP23784 RE38278 RE48591 RE56736 RH05467 RH05468 RH07009 RH07068 RH08188 RH08811 RH23467 RH32852 RH36452 RH36512 RH39049 RH39788 RH39840 RH39873 RH42404 RH42926 RH46195 RH46396 RH63203 RH63520 RH66374 RH68612 RH68921 RP003036153 RP003040786 RP003042549 RP003056916 RP003072751 RP003139705 RP003143133 RP003144266 RP003158540 RP003167705 RP003181841 RP003189614 RP003190110 RP003196378 RP003203296 RP003207840 RP003214961 RP003226503 RP003228824 RP003242102 RP003245206 RP003252697 RP003266368 RP003289599 RP003299468 RP003320375 RP003327057 RP003331645 RP003336747 RP003337383 RP003348466 RP003368540 RP003371763 RP003389315 RP003400493 RP003404170 RP003408279 RP003415140 RP003418828 RP003428886 RP003429918 RP003435272 RP003443408 RP003460263 RP003471054 RP003477944 RP003510433 RP003512681 RP003513336 RP003546976 RP003547650 RP003551798 RP003554560 RP003558253 RP003562424 RP003573527 RP003585706 RP003589692 RP003591445 RP003593038 RP003611419 RP003620112 RP003620615 RP003637782 RP003650034 RP003650817 RP003651522
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010411 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37292
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RpS18 CG8900 (Milshina, 1999.11)
Source for database merge of	Source for merge of: RpS18 anon-56Fa (FlyBase, 1996-) Source for merge of: RpS18 anon-EST:fe2D3 (Bayraktaroglu, 2000.11.2) Source for merge of: RpS18 BcDNA:RH43343 (FlyBase, 1996-)
Additional comments	"RpS18" likely corresponds to "M(2)56F". (Marygold et al., 2007) Source for merge of RpS18 anon-56Fa was comparison of Figure 2. in FBrf0068407 with the corresponding region of the release 4.2 genome (date:060307). (FlyBase, 1996-) Source for merge of RpS18 BcDNA:RH43343 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Likely Minute gene. (Marygold et al., 2007) Deletions removing RpS18 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype with a low cell count when assayed in Kc167 cells. (Eggert et al., 2004) An RpS18 cDNA has been cloned and sequenced. (Garwood and Lepesant, 1994) A clone (λDmS18) containing a ribosomal protein gene that may encode an RPS18 protein has been identified. The clone hybridises in situ to 15B. (Burns et al., 1984) This may correspond to M(2)56F (FBrf0073138). Burns et al. (FBrf0041468) identified a clone that hybrid-selected an RNA that translated to give a protein identified as RPS18. The clone (λDmS18) hybridized in situ to 15B and these authors concluded that "M(1)o" (i.e. RpS5a) encoded this protein. McKim and Hawley (EMBL:U48394) have shown, however, that RpS5a encodes RPS5; the status of the gene encoded by λDmS18 remains uncertain.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057616 NM_166383 RefSeq (Proteins) • NP_476964 NP_725943 DDBJ / EMBL / GenBank • AA433253 AAA28870 AAF57491 AAM48463 AAM68401 AAO17671 AC004321 AF083275 AY118434 AY167137 BI614060 CZ468261 L22959 Entrez Gene - A searchable database of RefSeq genes. • 37292 UniProtKB/Swiss-Prot • P41094
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S13, conserved site (IPR018269) Ribosomal protein S13 (IPR001892) Ribosomal protein S13-like, H2TH (IPR010979)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62947 DroID - A comprehensive database of gene and protein interactions. • FBgn0010411 DRSC - Results from RNAi screens. • FBgn0010411 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010411 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8900-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010411 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37292 InParanoid A subset of ortholog calls from InParanoid. • AAEL009747-PA Aedes aegypti (mosquito) AGAP010375-PA Anopheles gambiae (mosquito) XP_625104.1 Apis mellifera (honey bee) NP_001119689.1 Acyrthosiphon pisum (pea aphid) At1g22780.1 Arabidopsis thaliana (wall cress) At1g34030.1 Arabidopsis thaliana (wall cress) At4g09800.1 Arabidopsis thaliana (wall cress) 91663 Batrachochytrium dendrobatidis (chytrid fungus) 114927 Branchiostoma floridae (lancelet) 124370 Branchiostoma floridae (lancelet) XP_001900844.1 Brugia malayi (roundworm nematode) BGIBMGA003197-PA Bombyx mori (silk worm) ENSBTAP00000003431 Bos taurus (bovine) CAL0001937 Candida albicans (a form of yeast) CBP05102 Caenorhabditis briggsae (nematode) CE14956 Caenorhabditis elegans (worm) ENSCAFP00000001357 Canis familiaris (dog) CAGL0G07227g Candida glabrata (haploid yeast) Chro.30283 Cryptosporidium hominis (obligate parasite) JA05976 Caenorhabditis japonica (nematode) CMB004C Cyanidioschyzon merolae (red alga) cn10042 Cryptococcus neoformans (yeast-like fungus) cgd3_2440 Cryptosporidium parvum (protozoan parasite) CPIJ014165 Culex pipens (mosquito) ENSCPOP00000017778 Cavia porcellus (guinea pig) 155649 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000008974 Ciona savignyi (sedentary tunicate) 228718 Capitella spl (polychaete worm) DDB0231058 Dictyostelium discoideum (amoeba) DEHA2F22308g Debaryomyces Hansenii (yeast) 300691 Daphnia pulex (daphnia) ENSDARP00000005719 Danio rerio (zebra fish) ENSECAP00000013663 Equus caballus (horse) NP_417757.1 Escherichia coli K12 (bacteria) XP_653090 Entamoeba histolytica (anaerobic protozoan) XP_654098 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012973 Gymnopilus aculeatus (mushroom) GL50803_15551 Giardia lamblia (flagellated protozoan) 157357 Hypsipyla robusta (cedar shoot borer) ENSP00000211372 Homo sapiens (human) ENSP00000363762 Homo sapiens (human) ENSP00000372554 Homo sapiens (human) KLLA0B01562g Kluyveromyces lactis (yeast) 198613 Lottia gigantea (owl limpet) LmjF36.0930 Leishmania major (virus) LmjF36.0940 Leishmania major (virus) 37988 Monocosta brevicollis (choanoflagellate) ENSMODP00000017765 Monodelphis domestica (gray opossum) ENSMMUP00000019224 Macaca mulatta (rhesus monkey) ENSMUSP00000008812 Mus musculus (house mouse) ENSMUSP00000079301 Mus musculus (house mouse) 245261 Nematostella vectensis (starlet anemone) XP_001601390.1 Nasonia vitripennis (wasp) ENSORLP00000001372 Oryzias latipes (japanese killifish) LOC_Os03g58050.1 Oryza sativa (asian rice) LOC_Os07g07709.1 Oryza sativa (asian rice) 29470 Ostreococcus tauri (green alga) PF11_0272 Plasmodium falciparum (protozoal parasite) PHUM001770-PA Pediculus humanus (human body louse) PP26087 Pristionchus pacificus (nematode) 175952 Physcomitrella patens (moss) 175960 Physcomitrella patens (moss) 184305 Physcomitrella patens (moss) 194376 Physcomitrella patens (moss) 195584 Physcomitrella patens (moss) 221618 Physcomitrella patens (moss) ENSPPYP00000023575 Pongo pygmaeus (orangutan) 47000 Phytophthora ramorum (sudden oak death pathogen) 108718 Phytophthora sojae (root rot pathogen) 551159 Populus trichocarpa (black cottonwood) 559569 Populus trichocarpa (black cottonwood) ENSPTRP00000030810 Pan troglodytes (chimpanzee) PVX_091925 Plasmodium vivax (protozoal parasite) ENSRNOP00000030371 Rattus norvegicus (norway rat) ENSRNOP00000047371 Rattus norvegicus (norway rat) 5047969 Sorghum bicolor (sorghum) YDR450W Saccharomyces cerevisiae (budding yeast) YML026C Saccharomyces cerevisiae (budding yeast) Smp_074780 Schistosoma mansoni (trematode parasite) SPBC16D10.11c Schizosaccharomyces pombe (fission yeast) SPCC1259.01c Schizosaccharomyces pombe (fission yeast) XP_001202116.1 Strongylocentrotus purpuratus (purple sea urchin) XP_794924.1 Strongylocentrotus purpuratus (purple sea urchin) 35456 Trichoplax adhaerens (metazoa) TA21115 Theileria annulata (apicomplexan parasite) XP_973632.1 Tribolium castaneum (red flour beetle) Tc00.1047053506679.100 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506679.94 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005526 Tetraodon nigroviridis (green spotted pufferfish) TP01_0351 Theileria parva (parasitic protozoan) 26893 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034159 Takifugu rubripes (pufferfish Takifugu) 3698.m00005 Tetrahymena thermophila (ciliate protozoa) 80898.m00101 Trichomonas vaginalis (parasitic flagellated protozoan) 81840.m00180 Trichomonas vaginalis (parasitic flagellated protozoan) 82437.m00006 Trichomonas vaginalis (parasitic flagellated protozoan) 86492.m00163 Trichomonas vaginalis (parasitic flagellated protozoan) 92069.m00272 Trichomonas vaginalis (parasitic flagellated protozoan) 94736.m00070 Trichomonas vaginalis (parasitic flagellated protozoan) 97119.m00162 Trichomonas vaginalis (parasitic flagellated protozoan) 97121.m00165 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000044004 Xenopus tropicalis (frog) YALI0D20614g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37292 modMine - Data generated by the modENCODE project. • FBgn0010411 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17400 LH15218 ISCW015565 FBgn0064254 FBgn0064271 FBgn0064312 FBgn0064360 FBgn0064375 JGI_V11_300691 FBgn0081386 FBgn0154510 FBgn0143838 FBgn0130493 FBgn0064610 FBgn0099717 FBgn0064749 CPIJ014165 BGIBMGA003197 ACYPI000081 GB12140 AGAP010375 AAEL009747 PB23085 PHUM463880 GLEAN_14405
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	anon-56Fa   anon-EST:fe2D3   anon-EST:Posey27   B (Axton et al., 1994) BcDNA:RH43343   CG8900 (Cermelli et al., 2006, Goshima et al., 2007, Marygold et al., 2007, Keleman et al., 2009.8.5, Spain et al., 2010, Ponton et al., 2011, Cammarato et al., 2011) rpS18 (Garwood, 1993, Garwood and Lepesant, 1994) RpS18 (Beller et al., 2006, Cermelli et al., 2006, Goshima et al., 2007, Marygold et al., 2007, Nie et al., 2009, Sakai et al., 2009, Spain et al., 2010) Rps18 (Sims et al., 2009) RS18_DROME (Storm and Sonnhammer, 2003) S18 (Brogna et al., 2002, Carpenter et al., 2009) unnamed (Schmid and Tautz, 1997)
Name Synonym	anon-fast-evolving-2D3   Ribosomal protein S18 (Cammarato et al., 2011) transcription unit B (Axton et al., 1994)
Secondary FlyBase IDs
	FBgn0014916 FBgn0025222 FBgn0062939
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Ponton et al., 2011, J. Insect Physiol. 57(6): 840--850 Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. [FBrf0213828] Spain et al., 2010, J. Biol. Chem. 285(35): 27457--27467 Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. [FBrf0211588] Show all research papers ...