3.3 (northern blot)
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Comment: Thorax and abdomen assayed together. Bands of 1.4 and 2.2kb detected.
SerT-mRNA expression resembles the distribution pattern of serotonin in the larval and adult CNS.
Embryonic expression of SerT mRNA in the ventral nerve cord is observed in two serotonergic neurons per hemisegment.
SerT transcripts are detected in RNA from adult heads but not in RNA from embryos or adult bodies.
SerT transcripts are detected in a restricted number of cell bodies in the ventral ganglion and the brain in late embryos. The cell bodies are just ventral to the neuropil and are generally clustered. Each suboesophageal hemiganglion contains three positive cell bodies. Each thoracic and abdominal hemiganglion contains two stained cell bodies, except A8, which contains a single stained cell body.
SerT-protein expression resembles the distribution pattern of serotonin in the larval and adult CNS.
GBrowse - Visual display of RNA-Seq signalsView Dmel\SerT in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: SerT CG4545
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
SerT possesses a number of functional properties of the Na+/Cl- superfamiliy, including a dependence on Na and Cl, a high affinity for 5HT and electrogenicity. SerT is coccaine-sensitive, possessing an unusual pharmacological profile.