l(2)35Cf, DmS-II, BG:DS00929.12
critical for efficient release of stalled RNA Pol II from intrinsic stop sites in promoter regions - promotes transcriptional elongation and decreases pausing
Please see the JBrowse view of Dmel\TfIIS for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
1.4 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TfIIS using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\TfIIS in GBrowse 22-50
2-47.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: TfIIS CG3710
Source for merge of: TfIIS l(2)35Cf
α-amanitin has an inhibitory effect on TfIIS-mediated transcript cleavage, but has no effect on elongation or pycophosphorolysis.
TfIIS is necessary and sufficient to activate nascent transcript cleavage by RNA polymerase II during transcription of a dC-tailed template in vitro.
2 alleles are discussed but are not named.