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FB2021_03, released June 15, 2021

Gene: Dmel\TpnC73F

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General Information
Symbol
Dmel\TpnC73F
Species
D. melanogaster
Name
Troponin C at 73F
Annotation Symbol
CG7930
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010424
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

TnC, TnC73F, DmTpnCIa, Tnc2

Key Links
Genomic Location
Cytogenetic map
73E5-73E5
Sequence location
3L:17,046,063..17,048,390 [+]
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17046063..17048390
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from biological aspect of ancestor with PANTHER:PTN000549682
(assigned by GO_Central )
(Gaudet et al., 2011)
enables enzyme regulator activity
inferred from biological aspect of ancestor with PANTHER:PTN000549861
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the troponin C family. (P47949)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TROPONIN C ISOFORMS -
The troponin complex associates with tropomyosin (Tm1) and controls the contraction of the striated muscle in response to changes in intracellular calcium concentration. Troponin C (TpnC) is the calcium-binding subunit of the troponin complex and, in insects, is encoded by multiple genes. (Adapted from FBrf0184125.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\TpnC73F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
TpnC73F-RA
FBtr0089585
NM_079398
962
155
TpnC73F-RC
FBtr0345120
NM_001300162
1059
155
Additional Transcript Data and Comments
Reported size (kB)

0.9 (northern blot)

(Fyrberg et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
TpnC73F-PA
FBpp0088546
17.7
155
3.81
NP_524122
AAF49371
TpnC73F-PC
FBpp0311345
17.7
155
3.81
NP_001287091
AHN58116
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

155 aa isoforms: TpnC73F-PA, TpnC73F-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

155 (aa)

(Fyrberg et al., 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TpnC73F using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
somatic muscle primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
organism
(Fyrberg et al., 1994)
larval stage
(Fyrberg et al., 1994)
pupal stage
(Fyrberg et al., 1994)
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Qiu et al., 2003)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
border follicle cell
(Borghese et al., 2006)
Additional Descriptive Data

TpnC73F is enriched in border follicle cells relative to follicle cells.

(Borghese et al., 2006)

Expression of TpnC73F was detected in 4 h embryos and persisted throughout development and into adult stages. However, expression was lower in the adult.

(Qiu et al., 2003)

TpnC73F transcripts are detected at nearly equal levels in late embryos, larvae, and pupae.

(Fyrberg et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\TpnC73F in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of TpnC73F
Transgenic constructs containing regulatory region of TpnC73F
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (36)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CALML6
3 of 15
Yes
No
Hsap\CABP4
2 of 15
No
Yes
Hsap\CALB1
2 of 15
No
No
Hsap\CALM1
2 of 15
No
No
Hsap\CALM2
2 of 15
No
No
1  
Hsap\CALM3
2 of 15
No
No
1  
Hsap\CALML4
2 of 15
No
No
Hsap\CALML5
2 of 15
No
No
Hsap\EFCAB6
2 of 15
No
Yes
Hsap\SPATA21
2 of 15
No
Yes
Hsap\AIF1
1 of 15
No
Yes
Hsap\AIF1L
1 of 15
No
Yes
Hsap\CABP1
1 of 15
No
No
Hsap\CABP2
1 of 15
No
No
Hsap\CABP5
1 of 15
No
No
Hsap\CABP7
1 of 15
No
No
Hsap\CALB2
1 of 15
No
No
Hsap\CALML3
1 of 15
No
No
Hsap\CALN1
1 of 15
No
No
Hsap\CAPS2
1 of 15
No
No
Hsap\CAPS
1 of 15
No
No
Hsap\CETN3
1 of 15
No
No
1  
Hsap\EFCAB2
1 of 15
No
No
Hsap\EFCAB3
1 of 15
No
No
Hsap\EFCAB7
1 of 15
No
Yes
Hsap\EFCAB9
1 of 15
No
No
Hsap\EFCAB11
1 of 15
No
No
Hsap\EFCAB13
1 of 15
No
Yes
Hsap\OCM2
1 of 15
No
Yes
Hsap\OCM
1 of 15
No
Yes
Hsap\PHF24
1 of 15
No
Yes
Hsap\PVALB
1 of 15
No
No
Hsap\RHBDL3
1 of 15
No
No
Hsap\SCGN
1 of 15
No
No
Hsap\TNNC1
1 of 15
No
No
1  
Hsap\TNNC2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cabp4
2 of 15
Yes
Yes
Mmus\Calb1
2 of 15
Yes
No
Mmus\Calm1
2 of 15
Yes
No
Mmus\Calm2
2 of 15
Yes
No
Mmus\Calm3
2 of 15
Yes
No
Mmus\Calm4
2 of 15
Yes
No
Mmus\Calm5
2 of 15
Yes
No
Mmus\Calml4
2 of 15
Yes
No
Mmus\Efcab6
2 of 15
Yes
Yes
Mmus\Spata21
2 of 15
Yes
Yes
Mmus\1700023F06Rik
1 of 15
No
No
Mmus\Aif1l
1 of 15
No
Yes
Mmus\Aif1
1 of 15
No
Yes
Mmus\Cabp1
1 of 15
No
No
Mmus\Cabp2
1 of 15
No
No
Mmus\Cabp5
1 of 15
No
No
Mmus\Cabp7
1 of 15
No
No
Mmus\Calb2
1 of 15
No
No
Mmus\Calml3
1 of 15
No
No
Mmus\Caln1
1 of 15
No
No
Mmus\Caps2
1 of 15
No
No
Mmus\Efcab2
1 of 15
No
No
Mmus\Efcab3
1 of 15
No
No
Mmus\Efcab7
1 of 15
No
Yes
Mmus\Efcab9
1 of 15
No
No
Mmus\Efcab11
1 of 15
No
No
Mmus\Ocm
1 of 15
No
Yes
Mmus\Phf24
1 of 15
No
Yes
Mmus\Pvalb
1 of 15
No
No
Mmus\Rhbdl3
1 of 15
No
No
Mmus\Scgn
1 of 15
No
No
Mmus\Tnnc1
1 of 15
No
No
Mmus\Tnnc2
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (30)
Rnor\Cabp4
2 of 13
Yes
No
Rnor\Calm1
2 of 13
Yes
No
Rnor\Calm3
2 of 13
Yes
No
Rnor\Calml4
2 of 13
Yes
No
Rnor\Efcab6
2 of 13
Yes
Yes
Rnor\Spata21
2 of 13
Yes
Yes
Rnor\Aif1l
1 of 13
No
Yes
Rnor\Aif1
1 of 13
No
Yes
Rnor\Cabp1
1 of 13
No
No
Rnor\Cabp5
1 of 13
No
No
Rnor\Calb1
1 of 13
No
No
Rnor\Calb2
1 of 13
No
No
Rnor\Calm2
1 of 13
No
No
Rnor\Calml3
1 of 13
No
No
Rnor\Calml5
1 of 13
No
No
Rnor\Caln1
1 of 13
No
No
Rnor\Caps2
1 of 13
No
Yes
Rnor\Efcab2
1 of 13
No
No
Rnor\Efcab3
1 of 13
No
No
Rnor\Efcab7
1 of 13
No
Yes
Rnor\LOC100361655
1 of 13
No
No
Rnor\LOC100911628
1 of 13
No
No
Rnor\LOC100912538
1 of 13
No
No
Rnor\Ocm2
1 of 13
No
Yes
Rnor\Phf24
1 of 13
No
Yes
Rnor\Pvalb
1 of 13
No
No
Rnor\Rhbdl3
1 of 13
No
No
Rnor\Scgn
1 of 13
No
No
Rnor\Tnnc1
1 of 13
No
No
Rnor\Tnnc2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\cabp4
2 of 12
Yes
No
Xtro\calm1
2 of 12
Yes
No
Xtro\efcab6
2 of 12
Yes
Yes
Xtro\aif1l
1 of 12
No
Yes
Xtro\cabp7
1 of 12
No
No
Xtro\calb1
1 of 12
No
No
Xtro\calm2
1 of 12
No
No
Xtro\calml4
1 of 12
No
No
Xtro\cetn3
1 of 12
No
No
Xtro\LOC548651
1 of 12
No
No
Xtro\LOC100170419
1 of 12
No
Yes
Xtro\ocm.2
1 of 12
No
Yes
Xtro\ocm
1 of 12
No
Yes
Xtro\pgm1
1 of 12
No
No
Xtro\pvalb.1
1 of 12
No
Yes
Xtro\pvalb.2
1 of 12
No
Yes
Xtro\pvalb
1 of 12
No
No
Xtro\scgn
1 of 12
No
No
Xtro\tnnc1
1 of 12
No
No
Xtro\tnnc2
1 of 12
No
No
Danio rerio (Zebrafish) (38)
Drer\calm2b
2 of 15
Yes
No
Drer\calml4a
2 of 15
Yes
No
Drer\calml4b
2 of 15
Yes
No
Drer\si:ch211-197n1.2
2 of 15
Yes
Yes
Drer\aif1l
1 of 15
No
Yes
Drer\cabp1a
1 of 15
No
No
Drer\cabp2a
1 of 15
No
No
Drer\cabp4
1 of 15
No
Yes
Drer\cabp5a
1 of 15
No
No
Drer\cabp5b
1 of 15
No
No
Drer\cabp7b
1 of 15
No
No
Drer\calb1
1 of 15
No
No
Drer\calb2a
1 of 15
No
No
Drer\calb2b
1 of 15
No
No
Drer\calm1a
1 of 15
No
No
Drer\calm1b
1 of 15
No
No
Drer\calm2a
1 of 15
No
No
Drer\calm3a
1 of 15
No
No
Drer\calm3b
1 of 15
No
No
Drer\caln1
1 of 15
No
No
Drer\caln2
1 of 15
No
No
Drer\caps2
1 of 15
No
Yes
Drer\cetn3
1 of 15
No
No
Drer\efcab2
1 of 15
No
No
Drer\efcab11
1 of 15
No
No
Drer\phf24
1 of 15
No
Yes
Drer\pvalb1
1 of 15
No
No
Drer\pvalb3
1 of 15
No
Yes
Drer\pvalb4
1 of 15
No
Yes
Drer\pvalb6
1 of 15
No
No
Drer\pvalb8
1 of 15
No
Yes
Drer\pvalb9
1 of 15
No
Yes
Drer\rhbdl3
1 of 15
No
No
Drer\scgn
1 of 15
No
No
Drer\si:cabz01076231.1
1 of 15
No
Yes
Drer\tnnc1a
1 of 15
No
No
Drer\tnnc1b
1 of 15
No
No
Drer\tnnc2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (22)
Cele\tnc-2
12 of 15
Yes
Yes
Cele\pat-10
4 of 15
No
Yes
Cele\cal-3
2 of 15
No
No
Cele\cal-8
2 of 15
No
Yes
Cele\F43C9.2
2 of 15
No
No
Cele\K03A1.4
2 of 15
No
No
Cele\B0563.7
1 of 15
No
No
Cele\bath-25
1 of 15
No
Yes
Cele\C50C3.5
1 of 15
No
Yes
Cele\cal-1
1 of 15
No
No
Cele\cal-2
1 of 15
No
No
Cele\cal-4
1 of 15
No
No
Cele\cal-5
1 of 15
No
No
Cele\cal-6
1 of 15
No
No
Cele\cal-7
1 of 15
No
No
Cele\cbn-1
1 of 15
No
Yes
Cele\cmd-1
1 of 15
No
No
Cele\E02A10.3
1 of 15
No
No
Cele\H10E21.4
1 of 15
No
Yes
Cele\T02G5.3
1 of 15
No
Yes
Cele\T09B4.4
1 of 15
No
No
Cele\Y73C8B.5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (16)
Atha\AT1G18530
1 of 9
Yes
No
Atha\AT1G21550
1 of 9
Yes
Yes
Atha\AT1G32250
1 of 9
Yes
No
Atha\AT1G76640
1 of 9
Yes
Yes
Atha\AT3G01830
1 of 9
Yes
Yes
Atha\AT3G03000
1 of 9
Yes
No
Atha\AT3G25600
1 of 9
Yes
No
Atha\AT3G29000
1 of 9
Yes
Yes
Atha\AT4G26470
1 of 9
Yes
No
Atha\CAM8
1 of 9
Yes
No
Atha\CAM9
1 of 9
Yes
Yes
Atha\CML11
1 of 9
Yes
No
Atha\CML37
1 of 9
Yes
No
Atha\CML38
1 of 9
Yes
Yes
Atha\CML42
1 of 9
Yes
Yes
Atha\CML43
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\CMD1
2 of 15
Yes
No
Scer\MLC1
1 of 15
No
No
Scer\MLC2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cam1
1 of 12
Yes
No
Spom\cam2
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190I8E )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004002
Drosophila simulans
Dsim\GD14691
Drosophila sechellia
Dsec\GM25686
Drosophila ananassae
Dana\GF10103
Drosophila pseudoobscura pseudoobscura
Dpse\TpnCIa
Drosophila persimilis
Dper\GL11919
Drosophila willistoni
Dwil\GK15267
Drosophila virilis
Dvir\TpnCIa
Drosophila mojavensis
Dmoj\GI12482
Drosophila grimshawi
Dgri\GH16402
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150FAJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014129
Musca domestica
House fly
Mdoa\17010514
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10730
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02453
Mayetiola destructor
Hessian fly
Mdes\Mdes011802
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000744
Anopheles darlingi
American malaria mosquito
Adar\ADAC008801
Anopheles gambiae
Malaria mosquito
Agam\AGAP007339
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003058
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0K0R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006937
Bombyx mori
Silkmoth
Bmor\BGIBMGA006743
Bombyx mori
Silkmoth
Bmor\BGIBMGA006742
Bombyx mori
Silkmoth
Bmor\BGIBMGA008861
Bombyx mori
Silkmoth
Bmor\BGIBMGA009869
Danaus plexippus
Monarch butterfly
Dple\DPOGS212111-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213018-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200878-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012299
Heliconius melpomene
Postman butterfly
Hmel\HMEL012523
Heliconius melpomene
Postman butterfly
Hmel\HMEL015053
Apis florea
Little honeybee
Aflo\2147512483
Apis florea
Little honeybee
Aflo\2314379300
Apis florea
Little honeybee
Aflo\4286594100
Apis florea
Little honeybee
Aflo\4286594132
Apis florea
Little honeybee
Aflo\2147627043
Apis mellifera
Western honey bee
Amel\GB45174
Apis mellifera
Western honey bee
Amel\GB40619
Apis mellifera
Western honey bee
Amel\GB45211
Apis mellifera
Western honey bee
Amel\GB40618
Apis mellifera
Western honey bee
Amel\GB48216
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23579
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19855
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20048
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21857
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20049
Bombus terrestris
Buff-tailed bumblebee
Bter\15205981
Bombus terrestris
Buff-tailed bumblebee
Bter\15211469
Bombus terrestris
Buff-tailed bumblebee
Bter\15205980
Bombus terrestris
Buff-tailed bumblebee
Bter\15210139
Bombus terrestris
Buff-tailed bumblebee
Bter\15211564
Linepithema humile
Argentine ant
Lhum\LH12676
Linepithema humile
Argentine ant
Lhum\LH13999
Linepithema humile
Argentine ant
Lhum\LH21881
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001f76
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00070e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001800
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0006a4
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG032116
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005449
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG029990
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019186
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002564
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011404
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12222
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05626
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03086
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08434
Tribolium castaneum
Red flour beetle
Tcas\TC005470
Tribolium castaneum
Red flour beetle
Tcas\TC006493
Tribolium castaneum
Red flour beetle
Tcas\TC012704
Tribolium castaneum
Red flour beetle
Tcas\TC012196
Pediculus humanus
Human body louse
Phum\PHUM494800
Pediculus humanus
Human body louse
Phum\PHUM369310
Rhodnius prolixus
Kissing bug
Rpro\RPRC012224
Rhodnius prolixus
Kissing bug
Rpro\RPRC007075
Rhodnius prolixus
Kissing bug
Rpro\RPRC014921
Cimex lectularius
Bed bug
Clec\CLEC006709
Cimex lectularius
Bed bug
Clec\CLEC001757
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007392
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009055
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000699
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007505
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04924
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06448
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09713
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13044
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0K6P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004800
Strigamia maritima
European centipede
Smar\SMAR011877
Strigamia maritima
European centipede
Smar\SMAR008448
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58477.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73629.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g00800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_442789
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_442805
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_442804
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0V73 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Odadc3L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Calm1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Odadc3L2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Calm2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005036gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_024195gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Calm
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020033gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Odadc3L3
Ciona intestinalis
Vase tunicate
Cint\LOC494376
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000627
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008615
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008616
Gallus gallus
Domestic chicken
Ggal\CALM
Gallus gallus
Domestic chicken
Ggal\CALML3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026445
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (24)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
TpnC47D
9 of 10
TpnC41C
6 of 10
TpnC25D
5 of 10
CG11638
3 of 10
TpnC4
3 of 10
Acam
2 of 10
azot
2 of 10
Cam
2 of 10
Cbp53E
2 of 10
CG5024
2 of 10
CG9406
2 of 10
CG13526
2 of 10
CG13898
2 of 10
CG17272
2 of 10
CG17770
2 of 10
CG30378
2 of 10
CG31960
2 of 10
Eip63F-1
2 of 10
CG10126
1 of 10
CG11041
1 of 10
CG17493
1 of 10
CG31345
1 of 10
CG31802
1 of 10
CR31958
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CALML6; calmodulin like 6
    3 of 15
    610171
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-45
        Cytogenetic map
        73E5-73E5
        Sequence location
        3L:17,046,063..17,048,390 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        73E5-73E5
        Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        73F-73F
        (Fyrberg, 1993.11.8)
        73F-73F
        (determined by in situ hybridisation)
        (Fyrberg et al., 1994)
        Experimentally Determined Recombination Data
        Location

        3-45

        (FlyBase, 2016)

        3-39.8

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (104)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.

        (Liu and Lehmann, 2008)

        Isolation and characterisation of Troponin C like gene TpnC73F.

        (Fyrberg et al., 1994)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 43 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB
        EMBL-EBI Single Cell Expression Atlas
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (17)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (59)