• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\mtrm

General Information
Symbol	Dmel\mtrm	Species	D. melanogaster
Name	matrimony	Annotation symbol	CG18543
Feature type	protein_coding_gene	FlyBase ID	FBgn0010431
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	D52
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66C11-66C11	Sequence location	3L:8,406,112..8,407,203 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene matrimony is referred to in FlyBase by the symbol Dmel\mtrm (CG18543, FBgn0010431). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of meiotic cell cycle; female meiosis chromosome segregation; distributive segregation. 14 alleles are reported. The phenotypes of these alleles are annotated with: cystoblast; karyosome. It has one annotated transcript and one annotated polypeptide. Protein features are: Sterile alpha motif domain; Sterile alpha motif, type 1; Sterile alpha motif/pointed domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1629445_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mtrm. Gene sequence location is 3L:8406112..8407203.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66C11-66C11   Limits computationally determined from genome sequence between P{lacW}l(3)L0139L0139 and P{PZ}Gug03928&P{EP}CG6745EP595b
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mtrm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mtrm-RA FBtr0076613  NM_139966   1092   217
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mtrm-PA   FBpp0076340   24.8   217   8.76     NP_648223   AAF50422
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sterile alpha motif domain (IPR001660) Sterile alpha motif, type 1 (IPR021129) Sterile alpha motif/pointed domain (IPR013761)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801997   AE014296 AAF50422   AI546359   AW943933   AY061524 AAL29072   BI213517   BI235687   BI366613   BI368783   BI485890   BI577296   BI577652   BI577858   BI580014   BP547363   BQ103295   CO177665   CO185216   CO262695   CO287942   CO289412   CO318233   EC066774   EC070272   EC079848   EC194496   EC204678   EC208056   EC218458   EC219462   EC241998   EV575309   EV576075   EV578050   EV578743   EV580518   EV580601   EV580889   EV581874   EV583317   EV584189   EV584658   EV586350   EV589725   EV590701   EV593303   EV595694   EV596593   EV599145   EV599694   EV600568   GH944190   GH945393   GH947828   GH955999   GH956025   GH956191   GH959981   GH959984   GH960191   GH960419   GH961058   GH962480   GH964053   GH964555   GH967385   GH970355   GH975525   GH977991   GH981224   GH982830   GH984440   U03288 AAA03463
UniProtKB/Swiss-Prot	Q23973
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage | female   ovary   (Xiang et al., 2007) oogenesis stage S4 -- S12   nurse cell   (Xiang et al., 2007) oocyte   (Xiang et al., 2007) oogenesis stage S13   oocyte   (Xiang et al., 2007) Comment:greatly reduced level
Additional Descriptive Data
	mtrm protein is only detected in ovaries. It is observed in nurse cells and in the oocyte from stage S4. While first restricted to the nucleus, it reaches maximum levels and is found throughout the oocyte after stage 10. Staining is greatly reduced at stage 13. (Xiang et al., 2007)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Xiang et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary    1947.7 Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary  (1947.7) Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary  (1947.7) Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary    1947.7 Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary    1947.7 Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary  (1947.7) Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary  (1947.7) Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.675 Larval Midgut    4.9 Larval Hindgut    5.5 Larval Malpighian Tubules    7.4 Larval Fat Body    7.4 Larval Salivary Gland    10.4 Larval Trachea    8.15 Larval Carcass    5 Adult Head    5.3 Adult Eye    7.725 Adult Brain    12 Adult Thoracic-Abdominal Ganglion    12.3 Adult Crop    8.2 Adult Midgut    6 Adult Hindgut    6.1 Adult Malpighian Tubules    23 Adult Fat Body    23.1 Adult Salivary Gland    16.6 Adult Heart    5.05 Adult VirginFemale Spermatheca    30.6 Adult InseminatedFemale Spermatheca    21 Adult Ovary    1947.7 Adult Testis    29.2 Adult Male Accessory Gland    11.4 Adult Carcass    44.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.3   NA  Eye    7.725   NA  Brain    12   22.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    12.3   NA  Crop    8.2   4.9  Midgut    6   5.5  Hindgut    6.1   7.4  Malpighian Tubules    no informative data   7.4  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    5.05   8.15  Trachea    NA   NA  VirginFemale Spermatheca    30.6   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1947.7   NA  Testis    29.2   NA  Male Accessory Gland    no informative data   5  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    245 ovary, mated 4-day female    198 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (245) ovary, mated 4-day female  (198) testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (245) ovary, mated 4-day female  (198) testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    245 ovary, mated 4-day female    198 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    245 ovary, mated 4-day female    198 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (245) ovary, mated 4-day female  (198) testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (245) ovary, mated 4-day female  (198) testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    9 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    245 ovary, mated 4-day female    198 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    381 embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day    90 adult female 05day    256 adult female 30day    232 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (381) embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day  (90) adult female 05day  (256) adult female 30day  (232) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (381) embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day    90 adult female 05day  (256) adult female 30day  (232) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    381 embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day    90 adult female 05day    256 adult female 30day    232 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    381 embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day    90 adult female 05day    256 adult female 30day    232 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (381) embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day  (90) adult female 05day  (256) adult female 30day  (232) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (381) embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day    90 adult female 05day  (256) adult female 30day  (232) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    381 embryo 02-04hr    24 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    2 adult female 01day    90 adult female 05day    256 adult female 30day    232 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    20 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    43 Cadmium 100 mM 48 hrs, 4-day adult    129 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    77 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    142 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    123 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult    20 heat shock, 4-day adult  (53) Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult  (43) Cadmium 100 mM 48 hrs, 4-day adult  (129) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (77) Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (142) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (123) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (95) Paraquat 10 mM 48 hrs, 4-day adult  (70) Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    20 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    43 Cadmium 100 mM 48 hrs, 4-day adult  (129) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    77 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (142) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (123) Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    20 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    43 Cadmium 100 mM 48 hrs, 4-day adult    129 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    77 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    142 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    123 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    20 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    43 Cadmium 100 mM 48 hrs, 4-day adult    129 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    77 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    142 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    123 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult    20 heat shock, 4-day adult  (53) Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult  (43) Cadmium 100 mM 48 hrs, 4-day adult  (129) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (77) Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (142) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (123) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (95) Paraquat 10 mM 48 hrs, 4-day adult  (70) Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    20 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    43 Cadmium 100 mM 48 hrs, 4-day adult  129 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    77 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  142 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  123 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    20 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    43 Cadmium 100 mM 48 hrs, 4-day adult    129 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    77 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    142 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    123 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	BDGP expression data • LD47919 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010431 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18543-RA;CG7127-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 mtrmGD1627 Sterility Allele female fertile mtrmexc21 female sterile | recessive mtrm126 male fertile mtrm126 Other Phenotypes Allele meiotic cell cycle defective | dominant mtrm126 mtrmexc13 Phenotype manifest in Allele cystoblast mtrm126 karyosome mtrm126 oocyte & nuclear chromosome mtrm126 oocyte nucleus | oogenesis stage S11 mtrm126 oocyte nucleus | oogenesis stage S12 mtrm126 mtrmexc13
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of mtrm Class Mutagen Stocks Known lesion mtrmKG08051 P-element activity 2 Yes mtrm126 loss of function allele P-element activity 0 Yes mtrmexc13 P-element activity 0 Yes mtrmexc21 P-element activity 0 Yes mtrmexc43 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mtrm Class Mutagen Stocks Known lesion mtrmGD1627 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtrmGL00354 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtrmKK113299 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtrmNIG.18543R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes mtrmS124A.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes mtrmScer\UAS.P\T.cHa in vitro construct - regulatory fusion 0 Yes mtrmScer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mtrmT40A.S124A.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes mtrmT40A.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1627} NA P{KK113299} NA P{NIG.18543R} NA P{TRiP.GL00354} NA P{UASp-mtrm.flag3x} NA P{UASp-mtrm.H} NA P{UASp-mtrm.S124A} NA P{UASp-mtrm.T40A.S124A} NA P{UASp-mtrm.T40A} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?SUPor-P}exo70exc43 NA P{SUPor-P}exo70KG08051 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
distributive segregation inferred from mutant phenotype (Harris et al., 2003) female meiosis chromosome segregation inferred from mutant phenotype (Harris et al., 2003) regulation of meiotic cell cycle inferred from mutant phenotype (Xiang et al., 2007)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Xiang et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle arrest non-traceable author statement (assigned by UniProtKB) (Edgar, 1993.11.8)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (assigned by UniProtKB) (Edgar, 1993.11.8)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
mtrm - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mtrm - Trx-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mtrm allele Gene References mtrmexc13 exo70 (Harris et al., 2003) mtrmexc43 exo70 (Harris et al., 2003) mtrmKG08051 exo70 (Harris et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64371 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010431 DroID - A comprehensive database of gene and protein interactions. • FBgn0010431 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38958
Orthologs
OrthoDB Orthologs (4) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RV3C4 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6RV3C4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mtrm     Drosophila persimilis   Dper\GL24705     Drosophila willistoni   Dwil\GK15529     Drosophila virilis   Dvir\GJ19117
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	35430 y1 sc* v1; P{TRiP.GL00354}attP2 14932 y1; P{SUPor-P}exo70KG08051 mtrmKG08051 ry506/TM3, Sb1 Ser1
Kyoto	111648 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}exo70KG08051 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
VDRC	v107579 P{KK113299}VIE-260B v44904 w1118 P{GD1627}v44904
Genomic Clones ( 1 )
	BACR13D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47919
Other clones	DPiM_LD47919
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03694 RE18934 RE31596 RE52188 RE54819 RE69243 RE70958 RE71363 RE71616 RE74133
Other clones	166511 CK01.6D.E8 CK01.16D.G9 CK01.66D.E1 CK01.85A.E12 CK01.90B.H4 CK01.102B.F3 Dmel_dig_003909_0714_0834 Dmel_dig_004985_0595_2164 Dmel_dig_006679_0704_2114 Dmel_dig_010886_0619_3528 Dmel_dig_011579_0640_2336 Dmel_dig_011904_0647_2124 Dmel_dig_013904_0603_1463 Dmel_dig_015020_0653_0874 Dmel_dig_015344_0660_0732 Dmel_dig_016164_0650_3163 Dmel_dig_019060_0654_3055 Dmel_neb_002774_0567_1990 Dmel_neb_006741_0679_3586 Dmel_neb_008799_0866_2558 Dmel_neb_010160_0171_0679 Dmel_neb_010189_0376_2163 Dmel_neb_010916_0895_1577 Dmel_neb_012111_0931_2950 Dmel_neb_012746_0323_1748 Dmel_neb_015428_0864_2207 EC29942 EK054017 EK067352 EK070962 EK086122 EK271120 FGH116B09 RP004083569 RP004086219 RP004086997 RP004198658 RP004204651 RP004216177 RP004230816 RP004234575 RP004243466 RP004265911 RP004340547 RP004429175 RP004467855 RP004502231 RP004506927 RP004524686 RP004539957 RP004545057 RP004547935 RP004550035 RP004550430 UUGC0698
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010431 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38958
Antibody Information
	polyclonal (Xiang et al., 2007)
Other Information
Discoverer
Etymology
	The gene is named "matrimony" because it appears to hold paired chromosomes together (during female meiosis). (Harris et al., 2003)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mtrm CG18543 (Harris et al., 2003)
Source for database merge of
Additional comments
Other Comments
	Haploinsufficient locus (not associated with strong haplolethality or haplosterility). (Cook et al., 2012) Mutants show a dominant effect on achiasmate chromosome disjunction in oocytes. (Harris et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: cloned by ability to arrest the cell cycle when expressed in the fission yeast Schizosaccharomyces pombe. (Edgar, 1993.11.8)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139966 RefSeq (Proteins) • NP_648223 DDBJ / EMBL / GenBank • AAA03463 AAF50422 AAL29072 AI546359 AW943933 AY061524 U03288 Entrez Gene - A searchable database of RefSeq genes. • 38958 UniProtKB/Swiss-Prot • Q23973
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sterile alpha motif domain (IPR001660) Sterile alpha motif, type 1 (IPR021129) Sterile alpha motif/pointed domain (IPR013761) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD47919
Linkouts
	BioGRID - A database of protein and genetic interactions • 64371 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010431 DroID - A comprehensive database of gene and protein interactions. • FBgn0010431 DRSC - Results from RNAi screens. • FBgn0010431 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010431 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18543-RA;CG7127-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010431 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38958 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/matrimony.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38958 modMine - Data generated by the modENCODE project. • FBgn0010431
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anonD52   anon-D52   CG18543 (Harris et al., 2003, Arbeitman et al., 2002, Fouix et al., 2003, Toledano-Katchalski et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) D52 (Edgar, 1993.11.8, Schultz et al., 1997, ) mtrm (Xiang et al., 2007, Harris et al., 2003, Bickel and Subramanian, 2008, Xiang et al., 2007, Anderson et al., 2009, Subramanian and Bickel, 2008, Reis et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Cook et al., 2012)
Name Synonym	matrimony (Harris et al., 2003, Xiang et al., 2007, Subramanian and Bickel, 2008)
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Cook et al., 2012, Genome Biol. 13(3): R21 The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. [FBrf0219066] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Von Stetina et al., 2011, G3 (Bethesda) 1(7): 607--613 A Genetic Screen for Dominant Enhancers of the Cell-Cycle Regulator α-Endosulfine Identifies Matrimony as a Strong Functional Interactor in Drosophila. [FBrf0217588] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...