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Gene Dmel\cora

General Information
Symbol	Dmel\cora	Species	D. melanogaster
Name	coracle	Annotation symbol	CG11949
Feature type	protein_coding_gene	FlyBase ID	FBgn0010434
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	Cor, D4.1
Genomic Location
Chromosome (arm)	2R	Recombination map	2-86.9
Cytogenetic map	56C4-56C4	Sequence location	2R:15,116,568..15,131,256 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene coracle is referred to in FlyBase by the symbol Dmel\cora (CG11949, FBgn0010434). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process: adult somatic muscle development; embryonic morphogenesis; maintenance of imaginal disc-derived wing hair orientation; regulation of tube size, open tracheal system; establishment of glial blood-brain barrier. 44 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; external compound sense organ; adult; non-connected developing system; apical junction complex; adult segment; septate junction; dorsal trunk primordium; cell-cell junction; sense organ; embryonic foregut. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Band 4.1 domain; Band 4.1 family; Band 4.1, C-terminal; FERM adjacent (FA); FERM central domain; FERM conserved site; FERM domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM/acyl-CoA-binding protein, 3-helical bundle; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult salivary gland, inseminated spermatheca, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627454_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of cora. Gene sequence location is 2R:15116568..15131256.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms smooth septate junction
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56C4-56C4   Limits computationally determined from genome sequence between P{PZ}ena02029&P{lacW}corak08713 and P{lacW}htsk06121
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56C-56C     (Fehon, 1994.3.29) 56C1-56C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 56C-56C   (determined by in situ hybridisation)   (Fehon et al., 1994) 56C1-56C2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-86.9 (Fehon et al., 1994)
Left of (cM)	px (Fehon et al., 1994) wbl (Konsolaki and Schupbach, 1998)
Right of (cM)	c (Fehon et al., 1994)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cora for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cora-RA FBtr0086509  NM_079067   5899   1698 cora-RB FBtr0086508  NM_166337   3472   889 cora-RC FBtr0086506  NM_166336   2914   703 cora-RE FBtr0301279  NM_166338   2902   699 cora-RF FBtr0340468     5605   1600 cora-RG FBtr0340469     5893   1696
Additional Transcript Data & Comments
Reported size (kB)	6.3, 3.6, 2.9 (northern blot) (Fehon et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cora-PA   FBpp0085697   184.2   1698   9.17     NP_523791   AAF57592 cora-PB   FBpp0085696   98.0   889   6.81     NP_725865   AAF57591 cora-PC   FBpp0085694   78.2   703   7.99     NP_725864   AAF57593 cora-PE   FBpp0290494   77.8   699   8.74     NP_725866   AAM70846 cora-PF   FBpp0309410   173.9   1600   9.27       cora-PG   FBpp0309411   183.9   1696   9.17
Additional Polypeptide Data & Comments
Reported size (kDa)	1698 (aa) (Fehon et al., 1994)
Comments	Antibodies were prepared against sequences from the 5' end of the coding sequence that are shared by all of the cora cDNAs as well as to a region specific to the 1698aa species. The staining pattern obtained with both antisera are not noticably different. (Fehon et al., 1994)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Band 4.1, C-terminal (IPR008379) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) FERM adjacent (FA) (IPR014847) FERM, N-terminal (IPR018979) FERM, C-terminal PH-like domain (IPR018980) FERM conserved site (IPR019747) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202353   AA567695   AA697450   AE013599 AAF57591   AE013599 AAF57592   AE013599 AAF57593   AE013599 AAM70846   AI405008   AI533569   AQ034017   AY070992 AAL48614   BG636714   BI167855   BI169195   BI172414   BI216345   BI238902   BI242807   BI355183   BI364609   BI365259   BI368703   BI566469   BI571128   BI575310   BI579034   BI583465   BI584799   BI587563   BI606385   BI619937   BI627452   BI634219   BI637956   BI639725   BP543234   BP546848   BT024976   BT133208   CK661756   CL528044   CO178904   CO186335   CO264827   CO286632   CO290237   CO293434   CO296469   CO310847   CO312368   CO313754   CO320487   CO324402   CO327623   CO328390   CZ475890   CZ478552   CZ482878   EC051935   EC053485   EC067216   EC069214   EC069511   EC069819   EC201738   EC207804   EC212562   EC213485   EC220646   EC226179   EC229044   EC229390   EC236911   EC236919   EC239557   EC244344   EC246720   EC248145   EC252909   EC260248   EC260724   EL874745   EL874983   EL874989   EL874990   EL875091   EL875092   GH840286   GH941376   GH944329   GH944640   GH950266   GH952565   GH953596   GH963207   GH964094   GH965242   GH968445   GH974337   GH974739   GH979221   GH981366   GH982721   GH983034   GH983065   L27467 AAB59187   L27468 AAA28742   L27469 AAA28743
UniProtKB/Swiss-Prot	Q9V8R9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   atrium | precursor   (Fisher et al., 2012) Comment:reported as atrium primordium clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 17     (Fehon et al., 1994) Comment:reference states 4-20 hr AEL embryonic stage 12 -- 17     (Fehon et al., 1994) Comment:reference states 8-20 hr AEL larval stage     (Fehon et al., 1994) first instar larval stage     (Fehon et al., 1994) second instar larval stage     (Fehon et al., 1994)
Additional Descriptive Data
	The 3.6kb cora transcript is first detected in 8-12hr embryos and is detected through the remaining embryonic and early larval stages. (Fehon et al., 1994) The 6.3kb cora transcript is first detected in 4-8hr embryos, is much more abundant in 8-12hr embyros and remains prevalent through embryonic and larval stages. (Fehon et al., 1994) The 2.9kb cora transcript is first detected in 8-12hr embryos and is detected through the remaining embryonic and early larval stages. (Fehon et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis | early   germarium cap cell   • plasma membrane (de Cuevas et al., 1996) terminal filament   • plasma membrane (de Cuevas et al., 1996) follicle cell   • plasma membrane (de Cuevas et al., 1996) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17   embryonic/larval foregut   (Fehon et al., 1994) epidermis   (Fehon et al., 1994) embryonic/larval hindgut   (Fehon et al., 1994) embryonic stage 13 -- 17   abdominal 1 lateral pentascolopidial chordotonal organ lch5 -- abdominal 7 lateral pentascolopidial chordotonal organ lch5   (Fehon et al., 1994) embryonic/larval salivary gland   (Fehon et al., 1994) scolopidium   (Fehon et al., 1994) chordotonal organ   (Fehon et al., 1994) embryonic/larval trachea   (Fehon et al., 1994) embryonic stage 16   epithelial cell of embryonic/larval salivary gland   • septate junction (Paul et al., 2003) embryonic/larval tracheocyte   • septate junction (Paul et al., 2003) epidermal cell   • septate junction (Paul et al., 2003) embryonic/larval hindgut   • basolateral plasma membrane | apical of septate junction (Syed et al., 2011) larval stage & pupal stage   eye-antennal disc   (Fehon et al., 1994) wing disc   (Fehon et al., 1994) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	cora protein appears to be associated with the cytoplasmic face of septate junctions in epithelial cells. It does not appear to co-localize to a great extent with either filamentous actin or spectrin in the apical-basal axis of the cell. (Fehon et al., 1994) cora protein is first observed at the onset of germ band retraction in the epidermis, the hindgut, and the foregut. As the germ band retracts, expression increases in these tissues and appears in the tracheal branches and in the salivary glands. It is not expressed in the CNS but is observed in some sensory neural cells such as the scolopidia of the pentascolopidial chordotonal organ. (Fehon et al., 1994) cora protein is expressed in a short apical stretch of the basolateral membrane of embryonic septate junctions in the embryonic hindgut. (Syed et al., 2011) see cora-P1. (Fehon et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
NOT fusome inferred from direct assay (de Cuevas et al., 1996) plasma membrane inferred from direct assay (Khanna et al., 2010) septate junction inferred from direct assay (assigned by UniProtKB) (Fehon et al., 1994) smooth septate junction inferred from direct assay (Izumi et al., 2012) NOT spectrosome inferred from direct assay (de Cuevas et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult salivary gland, inseminated spermatheca, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea    546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain    583.3 Adult Thoracic-Abdominal Ganglion    565.6 Adult Crop    534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (583.375) Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea  (546.975) Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain  (583.3) Adult Thoracic-Abdominal Ganglion  (565.6) Adult Crop  534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea    546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain    583.3 Adult Thoracic-Abdominal Ganglion    565.6 Adult Crop    534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea    546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain    583.3 Adult Thoracic-Abdominal Ganglion    565.6 Adult Crop    534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea    546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain    583.3 Adult Thoracic-Abdominal Ganglion    565.6 Adult Crop    534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea  546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain  583.3 Adult Thoracic-Abdominal Ganglion  565.6 Adult Crop  534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea    546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain    583.3 Adult Thoracic-Abdominal Ganglion    565.6 Adult Crop    534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    583.375 Larval Midgut    317 Larval Hindgut    487.5 Larval Malpighian Tubules    79.5 Larval Fat Body    86.3 Larval Salivary Gland    347.5 Larval Trachea    546.975 Larval Carcass    391.425 Adult Head    348.1 Adult Eye    207.125 Adult Brain    583.3 Adult Thoracic-Abdominal Ganglion    565.6 Adult Crop    534 Adult Midgut    211.9 Adult Hindgut    300 Adult Malpighian Tubules    54.6 Adult Fat Body    79.4 Adult Salivary Gland    215.3 Adult Heart    265.475 Adult VirginFemale Spermatheca    65 Adult InseminatedFemale Spermatheca    106.9 Adult Ovary    54.6 Adult Testis    51.4 Adult Male Accessory Gland    237.4 Adult Carcass    339.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    348.1   NA  Eye    207.125   NA  Brain    583.3   583.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    565.6   NA  Crop    534   317  Midgut    211.9   487.5  Hindgut    300   79.5  Malpighian Tubules    54.6   86.3  Fat Body    79.4   347.5  Salivary Gland    215.3   NA  Heart    265.475   546.975  Trachea    NA   NA  VirginFemale Spermatheca    65   NA  InseminatedFemale Spermatheca    106.9   NA  Ovary    54.6   NA  Testis    51.4   NA  Male Accessory Gland    237.4   391.425  Carcass    339.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    90 central nervous system, pupae P8    129 head, virgin 1-day female    79 head, virgin 4-day female    77 head, virgin 20-day female    61 head, mated 1-day female    73 head, mated 4-day female    69 head, mated 20-day female    61 head, mated 1-day male    95 head, mated 4-day male    119 head, mated 20-day male    115 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    77 digestive system, 1-day adult    37 digestive system, 4-day adult    52 digestive system, 20-day adult    58 fat body, larvae L3 wandering    36 fat body, white prepupae    18 fat body, pupae P8    125 carcass, larvae L3 wandering    86 carcass, 1-day adult    85 carcass, 4-day adult    85 carcass, 20-day adult    87 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (85) central nervous system, larvae L3  (90) central nervous system, pupae P8  (129) head, virgin 1-day female  (79) head, virgin 4-day female  (77) head, virgin 20-day female  (61) head, mated 1-day female  (73) head, mated 4-day female  (69) head, mated 20-day female  (61) head, mated 1-day male  (95) head, mated 4-day male  (119) head, mated 20-day male  (115) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (77) digestive system, 1-day adult  (37) digestive system, 4-day adult  (52) digestive system, 20-day adult  (58) fat body, larvae L3 wandering  (36) fat body, white prepupae    18 fat body, pupae P8  (125) carcass, larvae L3 wandering  (86) carcass, 1-day adult  (85) carcass, 4-day adult  (85) carcass, 20-day adult  (87) ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    90 central nervous system, pupae P8  (129) head, virgin 1-day female    79 head, virgin 4-day female    77 head, virgin 20-day female    61 head, mated 1-day female    73 head, mated 4-day female    69 head, mated 20-day female    61 head, mated 1-day male    95 head, mated 4-day male  (119) head, mated 20-day male  (115) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    77 digestive system, 1-day adult    37 digestive system, 4-day adult    52 digestive system, 20-day adult    58 fat body, larvae L3 wandering    36 fat body, white prepupae    18 fat body, pupae P8  (125) carcass, larvae L3 wandering    86 carcass, 1-day adult    85 carcass, 4-day adult    85 carcass, 20-day adult    87 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    90 central nervous system, pupae P8    129 head, virgin 1-day female    79 head, virgin 4-day female    77 head, virgin 20-day female    61 head, mated 1-day female    73 head, mated 4-day female    69 head, mated 20-day female    61 head, mated 1-day male    95 head, mated 4-day male    119 head, mated 20-day male    115 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    77 digestive system, 1-day adult    37 digestive system, 4-day adult    52 digestive system, 20-day adult    58 fat body, larvae L3 wandering    36 fat body, white prepupae    18 fat body, pupae P8    125 carcass, larvae L3 wandering    86 carcass, 1-day adult    85 carcass, 4-day adult    85 carcass, 20-day adult    87 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    90 central nervous system, pupae P8    129 head, virgin 1-day female    79 head, virgin 4-day female    77 head, virgin 20-day female    61 head, mated 1-day female    73 head, mated 4-day female    69 head, mated 20-day female    61 head, mated 1-day male    95 head, mated 4-day male    119 head, mated 20-day male    115 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    77 digestive system, 1-day adult    37 digestive system, 4-day adult    52 digestive system, 20-day adult    58 fat body, larvae L3 wandering    36 fat body, white prepupae    18 fat body, pupae P8    125 carcass, larvae L3 wandering    86 carcass, 1-day adult    85 carcass, 4-day adult    85 carcass, 20-day adult    87 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (85) central nervous system, larvae L3  (90) central nervous system, pupae P8  (129) head, virgin 1-day female  (79) head, virgin 4-day female  (77) head, virgin 20-day female  (61) head, mated 1-day female  (73) head, mated 4-day female  (69) head, mated 20-day female  (61) head, mated 1-day male  (95) head, mated 4-day male  (119) head, mated 20-day male  (115) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (77) digestive system, 1-day adult  (37) digestive system, 4-day adult  (52) digestive system, 20-day adult  (58) fat body, larvae L3 wandering  (36) fat body, white prepupae    18 fat body, pupae P8  (125) carcass, larvae L3 wandering  (86) carcass, 1-day adult  (85) carcass, 4-day adult  (85) carcass, 20-day adult  (87) ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    90 central nervous system, pupae P8  129 head, virgin 1-day female    79 head, virgin 4-day female    77 head, virgin 20-day female    61 head, mated 1-day female    73 head, mated 4-day female    69 head, mated 20-day female    61 head, mated 1-day male    95 head, mated 4-day male  119 head, mated 20-day male  115 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    77 digestive system, 1-day adult    37 digestive system, 4-day adult    52 digestive system, 20-day adult    58 fat body, larvae L3 wandering    36 fat body, white prepupae    18 fat body, pupae P8  125 carcass, larvae L3 wandering    86 carcass, 1-day adult    85 carcass, 4-day adult    85 carcass, 20-day adult    87 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    90 central nervous system, pupae P8    129 head, virgin 1-day female    79 head, virgin 4-day female    77 head, virgin 20-day female    61 head, mated 1-day female    73 head, mated 4-day female    69 head, mated 20-day female    61 head, mated 1-day male    95 head, mated 4-day male    119 head, mated 20-day male    115 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    77 digestive system, 1-day adult    37 digestive system, 4-day adult    52 digestive system, 20-day adult    58 fat body, larvae L3 wandering    36 fat body, white prepupae    18 fat body, pupae P8    125 carcass, larvae L3 wandering    86 carcass, 1-day adult    85 carcass, 4-day adult    85 carcass, 20-day adult    87 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    10 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    46 embryo 08-10hr    74 embryo 10-12hr    116 embryo 12-14hr    161 embryo 14-16hr    162 embryo 16-18hr    131 embryo 18-20hr    195 embryo 20-22hr    146 embryo 22-24hr    148 larva L1    79 larva L2    52 larva L3 12hr old    48 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    38 white prepupae new    42 white prepupae 12hr    39 white prepupae 24hr    53 pupae 2d postWPP    70 pupae 3d postWPP    99 pupae 4d postWPP    50 adult male 01day    41 adult male 05day    42 adult male 30day    45 adult female 01day    32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr  (46) embryo 08-10hr  (74) embryo 10-12hr  (116) embryo 12-14hr  (161) embryo 14-16hr  (162) embryo 16-18hr  (131) embryo 18-20hr  (195) embryo 20-22hr  (146) embryo 22-24hr  (148) larva L1  (79) larva L2  (52) larva L3 12hr old  (48) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9  (38) white prepupae new  (42) white prepupae 12hr  (39) white prepupae 24hr  (53) pupae 2d postWPP  (70) pupae 3d postWPP  (99) pupae 4d postWPP  (50) adult male 01day  (41) adult male 05day  (42) adult male 30day  (45) adult female 01day  (32) adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    46 embryo 08-10hr    74 embryo 10-12hr  (116) embryo 12-14hr  (161) embryo 14-16hr  (162) embryo 16-18hr  (131) embryo 18-20hr  (195) embryo 20-22hr  (146) embryo 22-24hr  (148) larva L1    79 larva L2    52 larva L3 12hr old    48 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    38 white prepupae new    42 white prepupae 12hr    39 white prepupae 24hr    53 pupae 2d postWPP    70 pupae 3d postWPP    99 pupae 4d postWPP    50 adult male 01day    41 adult male 05day    42 adult male 30day    45 adult female 01day    32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    46 embryo 08-10hr    74 embryo 10-12hr    116 embryo 12-14hr    161 embryo 14-16hr    162 embryo 16-18hr    131 embryo 18-20hr    195 embryo 20-22hr    146 embryo 22-24hr    148 larva L1    79 larva L2    52 larva L3 12hr old    48 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    38 white prepupae new    42 white prepupae 12hr    39 white prepupae 24hr    53 pupae 2d postWPP    70 pupae 3d postWPP    99 pupae 4d postWPP    50 adult male 01day    41 adult male 05day    42 adult male 30day    45 adult female 01day    32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    46 embryo 08-10hr    74 embryo 10-12hr    116 embryo 12-14hr    161 embryo 14-16hr    162 embryo 16-18hr    131 embryo 18-20hr    195 embryo 20-22hr    146 embryo 22-24hr    148 larva L1    79 larva L2    52 larva L3 12hr old    48 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    38 white prepupae new    42 white prepupae 12hr    39 white prepupae 24hr    53 pupae 2d postWPP    70 pupae 3d postWPP    99 pupae 4d postWPP    50 adult male 01day    41 adult male 05day    42 adult male 30day    45 adult female 01day    32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr  (46) embryo 08-10hr  (74) embryo 10-12hr  (116) embryo 12-14hr  (161) embryo 14-16hr  (162) embryo 16-18hr  (131) embryo 18-20hr  (195) embryo 20-22hr  (146) embryo 22-24hr  (148) larva L1  (79) larva L2  (52) larva L3 12hr old  (48) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9  (38) white prepupae new  (42) white prepupae 12hr  (39) white prepupae 24hr  (53) pupae 2d postWPP  (70) pupae 3d postWPP  (99) pupae 4d postWPP  (50) adult male 01day  (41) adult male 05day  (42) adult male 30day  (45) adult female 01day  32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    46 embryo 08-10hr    74 embryo 10-12hr  116 embryo 12-14hr  (161) embryo 14-16hr  (162) embryo 16-18hr  131 embryo 18-20hr  (195) embryo 20-22hr  (146) embryo 22-24hr  (148) larva L1    79 larva L2    52 larva L3 12hr old    48 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    38 white prepupae new    42 white prepupae 12hr    39 white prepupae 24hr    53 pupae 2d postWPP    70 pupae 3d postWPP    99 pupae 4d postWPP    50 adult male 01day    41 adult male 05day    42 adult male 30day    45 adult female 01day    32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    46 embryo 08-10hr    74 embryo 10-12hr    116 embryo 12-14hr    161 embryo 14-16hr    162 embryo 16-18hr    131 embryo 18-20hr    195 embryo 20-22hr    146 embryo 22-24hr    148 larva L1    79 larva L2    52 larva L3 12hr old    48 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    38 white prepupae new    42 white prepupae 12hr    39 white prepupae 24hr    53 pupae 2d postWPP    70 pupae 3d postWPP    99 pupae 4d postWPP    50 adult male 01day    41 adult male 05day    42 adult male 30day    45 adult female 01day    32 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    78 embryonic 1182-4H    327 embryonic GM2    136 embryonic Kc167    73 embryonic S1    178 embryonic S3    45 leg disc CME L1    101 wing disc CME-W2    137 wing disc ML-DmD8    87 wing disc ML-DmD9    169 wing disc ML-DmD16-c3    161 wing disc ML-DmD21    41 wing disc ML-DmD32    257 haltere disc ML-DmD17-c3    165 eye-antennal disc ML-DmD11    298 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    245 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    86 ovary fGS/OSS    42 ovary OSC    86 ovary OSS    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4  (78) embryonic 1182-4H  (327) embryonic GM2  (136) embryonic Kc167  (73) embryonic S1  (178) embryonic S3  (45) leg disc CME L1  (101) wing disc CME-W2  (137) wing disc ML-DmD8  (87) wing disc ML-DmD9  (169) wing disc ML-DmD16-c3  (161) wing disc ML-DmD21  (41) wing disc ML-DmD32  (257) haltere disc ML-DmD17-c3  (165) eye-antennal disc ML-DmD11  (298) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (97) CNS ML-DmBG1-c1  (245) CNS ML-DmBG2-c2  (76) tumorous blood cells mbn2  (86) ovary fGS/OSS  (42) ovary OSC  (86) ovary OSS  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4    78 embryonic 1182-4H  (327) embryonic GM2  (136) embryonic Kc167    73 embryonic S1  (178) embryonic S3    45 leg disc CME L1  101 wing disc CME-W2  (137) wing disc ML-DmD8    87 wing disc ML-DmD9  (169) wing disc ML-DmD16-c3  (161) wing disc ML-DmD21    41 wing disc ML-DmD32  (257) haltere disc ML-DmD17-c3  (165) eye-antennal disc ML-DmD11  (298) antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1  (245) CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    86 ovary fGS/OSS    42 ovary OSC    86 ovary OSS    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    78 embryonic 1182-4H    327 embryonic GM2    136 embryonic Kc167    73 embryonic S1    178 embryonic S3    45 leg disc CME L1    101 wing disc CME-W2    137 wing disc ML-DmD8    87 wing disc ML-DmD9    169 wing disc ML-DmD16-c3    161 wing disc ML-DmD21    41 wing disc ML-DmD32    257 haltere disc ML-DmD17-c3    165 eye-antennal disc ML-DmD11    298 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    245 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    86 ovary fGS/OSS    42 ovary OSC    86 ovary OSS    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    78 embryonic 1182-4H    327 embryonic GM2    136 embryonic Kc167    73 embryonic S1    178 embryonic S3    45 leg disc CME L1    101 wing disc CME-W2    137 wing disc ML-DmD8    87 wing disc ML-DmD9    169 wing disc ML-DmD16-c3    161 wing disc ML-DmD21    41 wing disc ML-DmD32    257 haltere disc ML-DmD17-c3    165 eye-antennal disc ML-DmD11    298 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    245 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    86 ovary fGS/OSS    42 ovary OSC    86 ovary OSS    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4  (78) embryonic 1182-4H  (327) embryonic GM2  (136) embryonic Kc167  (73) embryonic S1  (178) embryonic S3  (45) leg disc CME L1  (101) wing disc CME-W2  (137) wing disc ML-DmD8  (87) wing disc ML-DmD9  (169) wing disc ML-DmD16-c3  (161) wing disc ML-DmD21  (41) wing disc ML-DmD32  (257) haltere disc ML-DmD17-c3  (165) eye-antennal disc ML-DmD11  (298) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (97) CNS ML-DmBG1-c1  (245) CNS ML-DmBG2-c2  (76) tumorous blood cells mbn2  (86) ovary fGS/OSS  (42) ovary OSC  (86) ovary OSS  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4    78 embryonic 1182-4H  (327) embryonic GM2  136 embryonic Kc167    73 embryonic S1  (178) embryonic S3    45 leg disc CME L1  101 wing disc CME-W2  137 wing disc ML-DmD8    87 wing disc ML-DmD9  (169) wing disc ML-DmD16-c3  (161) wing disc ML-DmD21    41 wing disc ML-DmD32  (257) haltere disc ML-DmD17-c3  (165) eye-antennal disc ML-DmD11  (298) antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1  (245) CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    86 ovary fGS/OSS    42 ovary OSC    86 ovary OSS    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    78 embryonic 1182-4H    327 embryonic GM2    136 embryonic Kc167    73 embryonic S1    178 embryonic S3    45 leg disc CME L1    101 wing disc CME-W2    137 wing disc ML-DmD8    87 wing disc ML-DmD9    169 wing disc ML-DmD16-c3    161 wing disc ML-DmD21    41 wing disc ML-DmD32    257 haltere disc ML-DmD17-c3    165 eye-antennal disc ML-DmD11    298 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    245 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    86 ovary fGS/OSS    42 ovary OSC    86 ovary OSS    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    26 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    35 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    36 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult  26 heat shock, 4-day adult  (28) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3  (35) Copper 15 mM 48 hrs, 4-day adult  (67) Zinc 5 mM 12 hrs, larvae L3  (35) Zinc 4.5 mM 48 hrs, 4-day adult  (84) Ethanol 2.5% 3 hrs, larvae L3  (31) Ethanol 5% 3 hrs, larvae L3  (43) Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (36) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (58) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    26 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    35 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    36 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    26 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    35 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    36 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    26 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    35 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    36 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult  26 heat shock, 4-day adult  28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3  (35) Copper 15 mM 48 hrs, 4-day adult  (67) Zinc 5 mM 12 hrs, larvae L3  (35) Zinc 4.5 mM 48 hrs, 4-day adult  (84) Ethanol 2.5% 3 hrs, larvae L3  31 Ethanol 5% 3 hrs, larvae L3  (43) Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (36) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (58) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    26 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    35 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    36 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    26 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    35 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    36 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • IP14940 RE08339 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010434 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11949-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cora Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | partially | recessive | somatic clone cora4 lethal | embryonic stage | recessive cora1 cora2 cora3 cora4 cora5 cora6 cora12 cora13 lethal | larval stage | recessive cora14 lethal | pupal stage, with Scer\GAL4pnr-MD237 coraGD1405 lethal | recessive cora4 cora5 cora7 cora8 cora9 cora10 cora11 corak08713 viable cora15 coraEY07598 Sterility Allele fertile coraEY07598 Other Phenotypes Allele cell polarity defective (with cora5) cora15 cell polarity defective (with cora15) cora5 neuroanatomy defective cora5 corak08713 neuroanatomy defective (with cora5) corak08713 neuroanatomy defective (with corak08713) cora5 neurophysiology defective cora5 corak08713 neurophysiology defective (with cora5) corak08713 neurophysiology defective (with corak08713) cora5 visible | recessive cora15 wild-type cora1-383.hs.T:Hsap\MYC cora1.Ubi-p63E cora2.Ubi-p63E cora3.Ubi-p63E corafl.hs.T:Hsap\MYC Phenotype manifest in Allele denticle belt cora5 dorsal closure embryo cora5 dorsal trunk primordium (with cora4) cora5 dorsal trunk primordium (with cora5) cora4 embryonic/first instar larval cuticle cora1 cora10 cora11 cora12 cora13 cora2 cora3 cora4 cora5 cora6 cora7 cora8 cora9 embryonic/first instar larval cuticle | dorsal cora1 cora12 cora13 cora2 cora3 cora4 cora5 cora6 embryonic/larval salivary gland | embryonic stage cora1 cora12 cora13 cora2 cora3 cora4 cora5 cora6 embryonic/larval tracheal system | embryonic stage 17 cora14 embryonic dorsal epidermis cora1 cora2 embryonic ganglionic branch & embryonic tracheole (with cora4) cora5 embryonic ganglionic branch & embryonic tracheole (with cora5) cora4 embryonic head cora2 eye cora14 cora15 cora2 cora8 eye | anterior cora14 cora8 eye equator cora15 cora2 indirect flight muscle, with Scer\GAL4Mef2.PR coraGD1405 interocellar bristle cora15 cora4 interommatidial bristle cora14 cora8 ocellar bristle cora15 cora4 ocellus cora15 cora4 ommatidium cora14 cora8 pleated septate junction cora5 presumptive embryonic/larval tracheal system cora5 presumptive embryonic salivary gland cora5 septate junction cora5 septate junction | embryonic stage cora5 wing hair (with cora5) cora15 wing hair (with cora15) cora5
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of cora Class Mutagen Stocks Known lesion corak08713 hypomorphic allele - genetic evidence P-element activity 2 Yes cora14 ethyl methanesulfonate 1 Yes cora5-HA-1705 1 -- corad07723 P-element activity 1 -- corae00697 piggyBac transposase 1 -- coraEY07598 P-element activity 1 -- coraMI00820 1 -- cora5 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- cora10 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cora11 ethyl methanesulfonate 0 -- cora12 ethyl methanesulfonate 0 -- cora13 ethyl methanesulfonate 0 -- cora15 ethyl methanesulfonate 0 -- cora1 loss of function allele 0 Yes cora2 loss of function allele 0 Yes cora3 ethyl methanesulfonate 0 -- cora4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cora6 antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cora7 ethyl methanesulfonate 0 -- cora8 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cora9 ethyl methanesulfonate 0 -- coraf00411 piggyBac transposase 0 -- coraunspecified 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cora Class Mutagen Stocks Known lesion coraGD1405 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes coraHM05144 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes coraHMS01413 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes coraKK109444 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cora1-167.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora1-1698.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes cora1-323.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora1-383.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora1-383.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes cora1.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - minigene 0 Yes cora106-167.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora106-383.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora1585-1698.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora2.Ubi-p63E in vitro construct - regulatory fusion 0 Yes cora207-383.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora3.Ubi-p63E in vitro construct - regulatory fusion 0 Yes cora378-1591.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cora378-1698.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes coradsRNA.cPa in vitro construct - RNAi 0 Yes coradsRNA.cRa in vitro construct - RNAi 0 Yes corafl.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC26 (Chen et al., 2005) Df(2R)cor-P97 (Lamb et al., 1998) Df(2R)enaGC8 (Lamb et al., 1998, Bradley and Andrew, 2001, Gertler et al., 1995) Df(2R)EP2445Δ1 (Bradley and Andrew, 2001) Df(2R)Exel6069 (Ryder, 2004.4.26) Df(2R)P34 (Spradling et al., 1999, Bradley and Andrew, 2001, BDGP Project Members, 1994-1999) Df(2R)rib-ex12 (Shim et al., 2001)
Not disrupted in	Df(2R)enaGC10 (Bradley and Andrew, 2001) Df(2R)F7 (Bradley and Andrew, 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-cora.1-167.T:Myc} NA P{hs-cora.1-323.T:Myc} NA P{hs-cora.1-383.T:Myc} NA P{hs-cora.106-167.T:Myc} NA P{hs-cora.106-383.T:Myc} NA P{hs-cora.207-383.T:Myc} NA P{hs-cora.378-1591.T:Myc} NA P{hs-cora.378-1698.T:Myc} NA P{hs-cora.1585-1698.T:Myc} NA P{hs-cora.fl.T:Myc} NA UAS construct P{GD1405} NA P{KK109444} NA P{TRiP.HM05144} NA P{TRiP.HMS01413} NA P{UAS-cora.1-383.T:Myc} NA P{UAS-cora.1-1698.T:Myc} NA characterization construct P{Ubi-cora.2} NA P{Ubi-cora.3} NA P{Ubi-cora} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP2545 NA P{EPgy2}coraEY07598 NA P{XP}corad07723 NA insertion of enhancer trap P{lacW}corak08713 No miscellaneous insertions Mi{MIC}coraMI00820 NA P{RS5}cora5-HA-1705 NA PBac{RB}corae00697 NA PBac{WH}coraf00411 NA insertion of enhancer trap binary system P{GawB}12.16712.167 No
Gene Ontology: Function, Process & Cellular Component ( 24 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult somatic muscle development inferred from mutant phenotype (Schnorrer et al., 2010) embryonic morphogenesis inferred from mutant phenotype (assigned by UniProtKB) (Fehon et al., 1994) establishment of glial blood-brain barrier inferred from mutant phenotype (Stork et al., 2008) maintenance of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Venema et al., 2004) regulation of tube size, open tracheal system inferred from mutant phenotype (Paul et al., 2003)
Cellular Component
CV term Evidence References
NOT fusome inferred from direct assay (de Cuevas et al., 1996) plasma membrane inferred from direct assay (Khanna et al., 2010) septate junction inferred from direct assay (assigned by UniProtKB) (Fehon et al., 1994) smooth septate junction inferred from direct assay (Izumi et al., 2012) NOT spectrosome inferred from direct assay (de Cuevas et al., 1996)
Terms Based on Predictions or Assertions ( 15 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR008379 (FlyBase Curators et al., 2004-) cytoskeletal protein binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural molecule activity inferred from electronic annotation with InterPro:IPR008379 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell-cell junction organization traceable author statement (Harden, 2002) chitin-based embryonic cuticle biosynthetic process traceable author statement (Tepass et al., 2001) cytoskeleton organization inferred from sequence or structural similarity with EMBL:AB019257 (FlyBase, 1992-) dorsal closure non-traceable author statement (Harden, 2002) traceable author statement (Noselli and Agnes, 1999, Tepass et al., 2001) embryo development non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) protein targeting to membrane traceable author statement (Cereijido et al., 2003) salivary gland morphogenesis traceable author statement (Tepass et al., 2001) septate junction assembly traceable author statement (Tepass et al., 2001)
Cellular Component
CV term Evidence References
apicolateral plasma membrane non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) cytoskeleton inferred from sequence or structural similarity with EMBL:AB019257 (FlyBase, 1992-) septate junction non-traceable author statement (Tepass et al., 2001, Hong et al., 2001, Swiss-Prot Project Members, 2002.3.1) traceable author statement (de Cuevas et al., 1996, Noselli and Agnes, 1999, Cereijido et al., 2003, Harden, 2002, Humbert et al., 2003)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cora - CG10465 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG12279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG4866 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG5850 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG6686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG6767 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CG7146 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CalpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - CanA1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - Hakai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - Lmpt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - Mob4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - Pdk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - Pka-R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - Rho1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - boly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - crn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - eya anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - metro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cora - pigeon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cora allele Gene References cora1 Egfr (Fehon et al., 1994) cora2 Egfr (Fehon et al., 1994) cora10 Egfr (Lamb et al., 1998) cora12 Egfr (Lamb et al., 1998) cora13 Egfr (Lamb et al., 1998) cora14 Egfr (Lamb et al., 1998) unspecified Egfr (Lamb et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62870 DroID - A comprehensive database of gene and protein interactions. • FBgn0010434 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37205
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CC4KQ Dipteran inclusive ortholog search EOG6S1TG3 Insect inclusive ortholog search EOG6932CP Arthropod inclusive ortholog search EOG69W0W4 Metazoa inclusive ortholog search EOG6D2KGQ
Orthologs in Drosophila Species (EOG6CC4KQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cora     Drosophila simulans   Dsim\GD11436 Y   Drosophila sechellia   Dsec\GM21939 Y   Drosophila erecta   Dere\GG21953 Y   Drosophila yakuba   Dyak\GE12026 Y   Drosophila ananassae   Dana\GF11579 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11291 Y   Drosophila persimilis   Dper\GL17638 Y   Drosophila willistoni   Dwil\GK20669 Y   Drosophila virilis   Dvir\GJ19773 Y   Drosophila mojavensis   Dmoj\GI18918 Y   Drosophila grimshawi   Dgri\GH23092 Y
Orthologs in non-Drosophila Dipterans (EOG6S1TG3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007888   Anopheles gambiae Malaria mosquito  Agam\AGAP012185   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006032
Orthologs in non-Dipteran Insects (EOG6932CP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44175   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011112   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15884   Atta cephalotes Leafcutter ant  Acep\ACEP16282   Atta cephalotes Leafcutter ant  Acep\ACEP10984   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12996   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14088   Linepithema humile Argentine ant  Lhum\LH17831   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11710   Solenopsis invicta Red fire ant  Sinv\SINV14856   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001268   Bombyx mori Silkmoth  Bmor\BGIBMGA009120   Bombyx mori Silkmoth  Bmor\BGIBMGA009121   Pediculus humanus Human body louse  Phum\PHUM204060   Pediculus humanus Human body louse  Phum\PHUM203840   Pediculus humanus Human body louse  Phum\PHUM203850   Tribolium castaneum Red flour beetle  Tcas\TC008668
Orthologs in non-Insect Arthropods (EOG69W0W4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_219239   Ixodes scapularis Deer tick  Isca\ISCW021021
Orthologs in non-Arthropod Metazoa (EOG6D2KGQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\frm-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008398gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001330gn   Danio rerio Zebrafish  Drer\epb41l3b   Danio rerio Zebrafish  Drer\ENSDARG00000060497   Danio rerio Zebrafish  Drer\CABZ01090303.1   Danio rerio Zebrafish  Drer\si:dkey-178k16.1   Danio rerio Zebrafish  Drer\si:ch211-173b8.1   Danio rerio Zebrafish  Drer\epb41b   Xenopus tropicalis Western clawed frog  Xtro\epb41l1   Xenopus tropicalis Western clawed frog  Xtro\epb41l3   Xenopus tropicalis Western clawed frog  Xtro\epb41l2   Xenopus tropicalis Western clawed frog  Xtro\epb41   Gallus gallus Domestic chicken  Ggal\EPB41L2   Gallus gallus Domestic chicken  Ggal\EPB41L1   Gallus gallus Domestic chicken  Ggal\GGA.43863   Gallus gallus Domestic chicken  Ggal\EPB41L3   Mus musculus House mouse  Mmus\Epb41   Mus musculus House mouse  Mmus\ENSMUSG00000024044   Mus musculus House mouse  Mmus\Epb4.1l2   Mus musculus House mouse  Mmus\Epb41l1   Rattus norvegicus Norway rat  Rnor\Epb41l1   Rattus norvegicus Norway rat  Rnor\Epb4.1l2   Rattus norvegicus Norway rat  Rnor\Epb4.1   Rattus norvegicus Norway rat  Rnor\Epb41l3   Homo sapiens Human  Hsap\EPB41L3   Homo sapiens Human  Hsap\DKFZp781H1755   Homo sapiens Human  Hsap\EPB41   Homo sapiens Human  Hsap\EPB41L1
Human Orthologs (4)
Gene OMIM HGNC Hsap\EPB41L3     Hsap\DKFZp781H1755     Hsap\EPB41     Hsap\EPB41L1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11436 Drosophila sechellia Dsec\GM21939 Drosophila erecta Dere\GG21953 Drosophila yakuba Dyak\GE12026 Drosophila ananassae Dana\GF11579 Drosophila pseudoobscura pseudoobscura Dpse\GA11291 Drosophila persimilis Dper\GL17638 Drosophila willistoni Dwil\GK20669 Drosophila virilis Dvir\GJ19773 Drosophila mojavensis Dmoj\GI18918 Drosophila grimshawi Dgri\GH23092
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	9099 P{neoFRT}43D cora14/CyO 16848 y1 w67c23; P{EPgy2}coraEY07598 34114 y1 w*; Mi{MIC}coraMI00820/SM6a 10801 y1 w67c23; P{lacW}corak08713/CyO 35003 y1 sc* v1; P{TRiP.HMS01413}attP2 28933 y1 v1; P{TRiP.HM05144}attP2/TM3, Sb1
Harvard	- P{XP}corad07723 - PBac{RB}corae00697
Kyoto	125353 w1118; P{RS5}cora5-HA-1705
VDRC	v108749 P{KK109444}VIE-260B v9787 w1118; P{GD1405}v9787 v9788 w1118; P{GD1405}v9788
	More stocks available...
Genomic Clones ( 1 )
	BACR19I21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 92 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP14940 RE08339
Other clones	FI18624
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24912 GM29771 HL01648 HL02495 LD02524 LP21443 RE10294 RE14891 RE23449 RE40241 RE42020 RE49769 RE50511 RE54716 RE73005 RH05950 RH22082 RH24080 RH28266 RH30587 RH36020 RH37646 RH51078 RH68774 RH72788 SD05448 SD14483 SD20153 SD22385
Other clones	7308 31251 65879 73453 80882 100081 101820 103715 103817 125069 180212 194378 214253.58 214317.61 214319.51 CK01.20B.D5 CK01.28B.B10 CK01.41C.G5 CK01.60B.E5 CK01.73C.F3 CK01.94B.G3 EC051935 EC053485 EK018812 EK057922 EK063419 EK073426 EK140424 EK193547 EK202918 EK213754 EK222816 EK228552 EK234008 EK285710 EP07731 EP09125 FGC019D04 FGH110G04 IP14840 IP15040 IP15140 RP003522825 RP004127158 RP004142775 RP004172060 RP004214876 RP004215525 RP004217882 RP004232253 RP004238761 RP004242187 RP004252479 RP004268504 RP004357549 RP004365641 RP004454842 RP004495541 RP004506412 RP004517168
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010434 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37205
Antibody Information
	monoclonal, polyclonal (Fehon et al., 1994, Fehon et al., 1994, Fehon et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cora CG11949 (Milshina, 1999.11)
Source for database merge of	Source for merge of: cora l(2)k08713 (Spradling et al., 1999)
Additional comments
Other Comments
	Appears to function to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development. (Venema et al., 2004) Proper targetting of pck gene product to the pleated septate junctions in the tracheal system depends on Nrx-IV and cora but not Fas3. (Behr et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) cora is a necessary component of the septate junction required for the maintenance of the transepithelial barrier. (Lamb et al., 1998) The amino-terminal 383 amino acids of cora define a functional domain that is both necessary and sufficient for proper septate junction localisation of the protein. This domain and the cytoplasmic domain of Nrx-IV interact directly. (Ward et al., 1998) Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling. (Woods et al., 1997) The cora gene product is a component of neither fusomes nor spectrosomes. (de Cuevas et al., 1996) cora mutants die early in embryogenesis as they fail to complete dorsal closure. cora interacts genetically with EgfrE1 and Ras85DV12. (Lamb and Fehon, 1995) The cora product is associated with a septate junction and may play a role in cell-cell interactions essential for normal development. (Fehon et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079067 NM_166336 NM_166337 NM_166338 RefSeq (Proteins) • NP_523791 NP_725864 NP_725865 NP_725866 DDBJ / EMBL / GenBank • AA697450 AAA28742 AAA28743 AAB59187 AAF57591 AAF57592 AAF57593 AAL48614 AAM70846 AQ034017 AY070992 BI167855 CL528044 CZ475890 CZ478552 CZ482878 L27467 L27468 L27469 Entrez Gene - A searchable database of RefSeq genes. • 37205 UniProtKB/Swiss-Prot • Q9V8R9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Band 4.1, C-terminal (IPR008379) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) FERM adjacent (FA) (IPR014847) FERM, N-terminal (IPR018979) FERM, C-terminal PH-like domain (IPR018980) FERM conserved site (IPR019747) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP14940 RE08339
Linkouts
	BioGRID - A database of protein and genetic interactions • 62870 DroID - A comprehensive database of gene and protein interactions. • FBgn0010434 DRSC - Results from RNAi screens. • FBgn0010434 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010434 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11949-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010434 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37205 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/coracle1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37205 modMine - Data generated by the modENCODE project. • FBgn0010434
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG11949 (Ramet et al., 2002, Goldstein and Gunawardena, 2000, Rogers et al., 2003, Keleman et al., 2009.8.5, Perkins et al., 2009, Khanna et al., 2010, Ni et al., 2011.7.19, Cammarato et al., 2011) Cor (Swanson et al., 2009, Sasikumar and Roy, 2009, Ng et al., 2006, Behr et al., 2003, Wu et al., 2004, Bilder et al., 2003, Tanentzapf and Tepass, 2003, Hemphala et al., 2003, Knust and Bossinger, 2002, Hong et al., 2001, Bilder and Perrimon, 2000, Noselli and Agnes, 1999, Hough et al., 1997, Zeitler et al., 2004, Paul et al., 2007, Choi et al., 2011, Warner and Longmore, 2009, Zhang and Ward, 2009, Warner and Longmore, 2009, Tiklova et al., 2010, Chung et al., 2009, Phillips and Thomas, 2006, Wang and Ward, 2010, Tjota et al., 2011) cor (Genova and Fehon, 2003, Paul et al., 2003, Feiguin et al., 2001, Cereijido et al., 2003, Paul et al., 2003, Tepass et al., 2001, Muller, 2000, Agnes and Noselli, 1999, Lamb et al., 1998, Ward et al., 1998, Konsolaki and Schupbach, 1998, Noselli, 1998, Anonymous, 1995, Woods et al., 1997, Ward and Fehon, 1996, Ward and Fehon, 1997, Wu et al., 2007, Wagner et al., 2009, Nelson et al., 2010) COR (Genova and Fehon, 2003, Bhat, 2003, Mueller and Bossinger, 2003) cora (Bogdanik et al., 2008, Barmina et al., 2005, Riedl et al., 2007, Tonning et al., 2005, Chen et al., 2005, Yi et al., 2008, Moyer and Jacobs, 2008, Stork et al., 2009, Dworkin et al., 2009, Laprise et al., 2010, Schnorrer et al., 2010, Bahri et al., 2010, Foley et al., 2010, Kertesz et al., 2007, Reid et al., 2012, Izumi et al., 2012, Irion, 2012, Shaik et al., 2012) Cora (Sasaki et al., 2007, Liebl and Featherstone, 2008, Tiklová et al., 2010, Araujo et al., 2007, Mirouse et al., 2007, Laval et al., 2008, Kapelnikov et al., 2008, Laprise et al., 2009, Kapelnikov et al., 2008, Yan et al., 2009, Forster et al., 2010, Forster et al., 2010, Nilton et al., 2010, Laplante et al., 2010, Bachmann et al., 2008, Yanagihashi et al., 2012) Coracle (Kim and McGinnis, 2011) D4.1 (de Cuevas et al., 1996, Fares et al., 1995, ) l(2)k08713 (BDGP Project Members, 1994-1999, ) unnamed (Goldstein and Gunawardena, 2000)
Name Synonym	Coracle (Swanson et al., 2009, Sasikumar and Roy, 2009, Ng et al., 2006, Bogdanik et al., 2008, Takizawa et al., 2003, Lim and Tomlinson, 2006, Daneman and Barres, 2005, Maitra et al., 2006, Rogers et al., 2003, Zeitler et al., 2004, Williams et al., 2005, Classen et al., 2005, Chen et al., 2005, Tjota et al., 2011, Choi et al., 2011, Tiklová et al., 2010, Laprise et al., 2006, Araujo et al., 2007, Mirouse et al., 2007, Bayraktar et al., 2006, Phillips and Thomas, 2006, Laval et al., 2008, Narasimha et al., 2008, Schulte et al., 2006, Kapelnikov et al., 2008, Sen et al., 2012, Laprise et al., 2009, Yan et al., 2009, Warner and Longmore, 2009, Zhang and Ward, 2009, Kohsaka et al., 2007, Warner and Longmore, 2009, Chung et al., 2009, Khanna et al., 2010, Jayaram et al., 2008, Nelson et al., 2010, Bahri et al., 2010, Nilton et al., 2010, Wang and Ward, 2010, Wang et al., 2010, Laplante and Nilson, 2011, Laplante et al., 2010, Syed et al., 2011, Gomez et al., 2012, Kim et al., 2012, Ile et al., 2012) coracle (Fehon, 1994.3.29, Fehon, 1994.3.29, Fehon, 1994.3.29, Lamb and Fehon, 1997, Barmina et al., 2005, Hoopfer et al., 2008, Stork et al., 2008, Paul et al., 2007, Wagner et al., 2009, Yi et al., 2008, Gorfinkiel and Arias, 2007, Stork et al., 2009, Laprise et al., 2010, Schnorrer et al., 2010, Kim et al., 2010, Cammarato et al., 2011, Hughes et al., 2010, Mitonaka et al., 2007, Reid et al., 2012, Eddison et al., 2012, Tjota et al., 2011, Irion, 2012, Paré et al., 2012) D4.1-Coracle (Baumgartner et al., 1996)
Secondary FlyBase IDs
	FBgn0005646 FBgn0022032
References ( 257 )
Generate a list of	All references relating to this gene ( 257 )
List References by type	Research paper  ( 150 ) Supplementary material  ( 16 ) Review  ( 36 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 31 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Letter  ( 1 )
Recent research papers ( 20 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Eddison et al., 2012, PLoS ONE 7(12): e51684 A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. [FBrf0220425] Gomez et al., 2012, J. Cell Biol. 199(7): 1131--1143 Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. [FBrf0220436] Ile et al., 2012, Development 139(14): 2535--2546 Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function. [FBrf0218686] Irion, 2012, PLoS ONE 7(3): e34248 Drosophila muscleblind Codes for Proteins with One and Two Tandem Zinc Finger Motifs. [FBrf0218003] Izumi et al., 2012, J. Cell Sci. 125(20): 4923--4933 A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut. [FBrf0220284] Kim et al., 2012, Neuron 73(1): 79--91 Integrins Establish Dendrite-Substrate Relationships that Promote Dendritic Self-Avoidance and Patterning in Drosophila Sensory Neurons. [FBrf0217191] Paré et al., 2012, PLoS ONE 7(5): e36254 The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. [FBrf0218280] Reid et al., 2012, Front. Cell. Infect. Microbiol. 2: 24 Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila. [FBrf0219288] Sen et al., 2012, J. Cell Biol. 199(4): 685--698 Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. [FBrf0219897] Shaik et al., 2012, Europ. J. Cell Biol. 91(3): 204--215 δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva. [FBrf0217466] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Yanagihashi et al., 2012, J. Cell Sci. 125(8): 1980--1990 Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila. [FBrf0218431] Choi et al., 2011, Mol. Biol. Cell 22(12): 2010--2030 The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled. [FBrf0213894] Kim and McGinnis, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(2): 650--655 Phosphorylation of Grainy head by ERK is essential for wound-dependent regeneration but not for development of an epidermal barrier. [FBrf0214191] Laplante and Nilson, 2011, J. Cell Biol. 192(2): 335--348 Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. [FBrf0212838] Marrone et al., 2011, Sci. Rep. 1: 47 Hyperthermic seizures and aberrant cellular homeostasis in Drosophila dystrophic muscles. [FBrf0217412] Oshima and Fehon, 2011, J. Cell Sci. 124(16): 2861--2871 Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. [FBrf0214577] Syed et al., 2011, J. Neurosci. 31(21): 7876--7885 The CD59 Family Member Leaky/Coiled Is Required for the Establishment of the Blood-Brain Barrier in Drosophila. [FBrf0213741] Tjota et al., 2011, J. Cell Sci. 124(17): 2914--2926 Annexin B9 binds to {beta}H-spectrin and is required for multivesicular body function in Drosophila. [FBrf0215049] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...