Cor, D4.1, l(2)k08713
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.50
6.3, 3.6, 2.9 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cora using the Feature Mapper tool.
cora mRNA localizes in a rim around the boutons of the neuromuscular junction.
The 6.3kb cora transcript is first detected in 4-8hr embryos, is much more abundant in 8-12hr embyros and remains prevalent through embryonic and larval stages.
The 3.6kb cora transcript is first detected in 8-12hr embryos and is detected through the remaining embryonic and early larval stages.
GBrowse - Visual display of RNA-Seq signalsView Dmel\cora in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Appears to function to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
cora is a necessary component of the septate junction required for the maintenance of the transepithelial barrier.
The amino-terminal 383 amino acids of cora define a functional domain that is both necessary and sufficient for proper septate junction localisation of the protein. This domain and the cytoplasmic domain of Nrx-IV interact directly.
Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.