FlyBase Gene Report: Dmel\pll

General Information

Symbol

Dmel\pll

Species

D. melanogaster

Name

pelle

Annotation Symbol

CG5974

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010441

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Pelle (pll) encodes a tyrosine kinase-like family serine-threonine protein kinase that functions in the Toll pathway, a signaling cascade that plays key roles in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptide production. [Date last reviewed: 2016-06-30]

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

97E11-97E11

Sequence location

3R:27,251,131..27,253,182 [-]

Recombination map

3-92

RefSeq locus

NT_033777 REGION:27251131..27253182

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (24 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:tub; FB:FBgn0003882

(Großhans et al., 1999, Schiffmann et al., 1999)

inferred from physical interaction with FLYBASE:Pli; FB:FBgn0025574

(Großhans et al., 1999)

inferred from physical interaction with FLYBASE:Tehao; FB:FBgn0026760

(Luo et al., 2001)

enables protein domain specific binding

inferred from physical interaction with UniProtKB:P22812

(assigned by UniProt )

(Xiao et al., 1999)

enables protein serine/threonine kinase activity

inferred from direct assay

(Daigneault et al., 2013, Luo et al., 2001, Shen et al., 2001, Shen and Manley, 1998)

inferred from mutant phenotype

(Liu et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (17 terms)

Terms Based on Experimental Evidence (13 terms)

CV Term

Evidence

References

involved_in antifungal innate immune response

inferred from mutant phenotype

(Tauszig et al., 2000)

involved_in determination of dorsal/ventral asymmetry

inferred from mutant phenotype

(assigned by UniProt )

(Galindo et al., 1995)

involved_in dorsal/ventral pattern formation

inferred from mutant phenotype

(Bergmann et al., 1996)

inferred from genetic interaction with FLYBASE:tub; FB:FBgn0003882

(Hecht and Anderson, 1993)

involved_in innate immune response

inferred from mutant phenotype

(Sun et al., 2002)

involved_in larval somatic muscle development

inferred from mutant phenotype

(Halfon and Keshishian, 1998)

involved_in positive regulation of antifungal peptide production

inferred from direct assay

(Tauszig-Delamasure et al., 2002)

inferred from mutant phenotype

(Lemaitre et al., 1996)

involved_in positive regulation of hippo signaling

inferred from genetic interaction with FLYBASE:Cka; FB:FBgn0044323

(Liu et al., 2016)

involved_in positive regulation of protein catabolic process

inferred from mutant phenotype

(Liu et al., 2016)

involved_in positive regulation of ubiquitin-dependent protein catabolic process

inferred from mutant phenotype

(Daigneault et al., 2013)

involved_in protein autophosphorylation

inferred from direct assay

(Luo et al., 2001)

involved_in protein phosphorylation

inferred from direct assay

(Luo et al., 2001, Shen and Manley, 1998)

involved_in Toll signaling pathway

inferred from mutant phenotype

(Daigneault et al., 2013, Huang et al., 2010, Sun et al., 2002, Horng and Medzhitov, 2001, Tauszig et al., 2000, Bergmann et al., 1996, Lemaitre et al., 1996)

inferred from genetic interaction with FLYBASE:Traf6; FB:FBgn0265464

(Shen et al., 2001)

inferred from genetic interaction with FLYBASE:dl; FB:FBgn0260632

(Norris and Manley, 1996)

inferred from genetic interaction with FLYBASE:Tl; FB:FBgn0262473

(Hecht and Anderson, 1993)

involved_in zygotic specification of dorsal/ventral axis

inferred from mutant phenotype

(Anderson and Nusslein-Volhard, 1984)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in apoptotic process

non-traceable author statement

(assigned by UniProt )

(Xiao et al., 1999)

involved_in cytokine-mediated signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000701353

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in hemocyte proliferation

traceable author statement

(Evans et al., 2003)

involved_in innate immune response

traceable author statement

(assigned by UniProt )

(Xiao et al., 1999)

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000784925

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in Toll signaling pathway

traceable author statement

(assigned by UniProt )

(Xiao et al., 1999)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(assigned by UniProt )

(Galindo et al., 1995)

inferred from direct assay

(Towb et al., 1998)

located_in plasma membrane

inferred from direct assay

(Towb et al., 1998)

inferred from direct assay

(assigned by UniProt )

(Galindo et al., 1995)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000784925

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000784925

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000701353

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

DORSAL GROUP

NON-RECEPTOR TLK KINASES

Pathway (FlyBase)

Toll-NF-κB Signaling Pathway Core Components

Positive Regulators of Hippo Signaling Pathway

Protein Family (UniProt)

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. (Q05652)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

DORSAL GROUP -: The Dorsal group genes encode components of the Toll pathway and were initially identified by maternal effect mutations resulting in the dorsalization of the embryo. (Adapted from FBrf0091014 and FBrf0223077).
NON-RECEPTOR TLK KINASES -: Non-receptor tyrosine kinase-like (TKL) kinases are a diverse group of intracellular serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs.

Pathway (FlyBase)

Toll-NF-κB Signaling Pathway Core Components -: In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. (Adapted from FBrf0091014 and FBrf0223077).
Positive Regulators of Hippo Signaling Pathway -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).

Protein Function (UniProtKB)

Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.

(UniProt, Q05652)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

pll: pelle

Maternal-effect lethal; homozygous females sterile. As in the mutant dl, lethal embryos produced by pll females lack ventral and lateral elements (Anderson and Nusslein-Volhard, 1984). Extreme pll embryos consist of a long, hollow tube with dorsal cuticular structures (Muller-Holtkamp et al., 1985). Dorsalization is also observed in the pattern of ftz stripes in pll embryos (Carroll et al., 1987). Injection of wild-type cytoplasm into pll embryos partially restores the normal embryonic pattern of development (Muller-Holtkamp et al., 1985).

Summary (Interactive Fly)

tyrosine kinase - Toll pathway - dorsal group - involved in signal transduction during induction of dorsal/ventral polarity during early embryogenesis - regulation of antimicrobial peptides.

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\pll for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

pll-RA

FBtr0085179

NM_057623

1931

501

pll-RB

FBtr0334732

NM_001276079

1852

501

Additional Transcript Data and Comments

Reported size (kB)

1.9 (northern blot)

(Shelton and Wasserman, 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

pll-PA

FBpp0084549

56.2

501

8.87

NP_476971

AAF56686

pll-PB

FBpp0306780

56.2

501

8.87

NP_001263008

AGB96388

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

501 aa isoforms: pll-PA, pll-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

501 (aa); 56 (kD)

(Shelton and Wasserman, 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via Death domain) with tub (via Death domain). Interacts with Pellino (Pli).

(UniProt, Q05652)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

1D2Z
1IK7

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pll using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

pll_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(Shelton and Wasserman, 1993)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage & pupal stage

(Shelton and Wasserman, 1993)

embryonic stage 1 -- 9

organism

(Shelton and Wasserman, 1993)

Additional Descriptive Data

pll transcripts are expressed most strongly in early embryos and adult females and are observed at a lower level throughout development.

(Shelton and Wasserman, 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(assigned by UniProt )

(Galindo et al., 1995)

inferred from direct assay

(Towb et al., 1998)

located_in plasma membrane

inferred from direct assay

(Towb et al., 1998)

inferred from direct assay

(assigned by UniProt )

(Galindo et al., 1995)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\pll in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\pll

View exonic expression by tissue for Dmel\pll

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010441

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010441

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5974-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5974

Flygut - An atlas of the Drosophila adult midgut

FBgn0010441

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 34 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of pll

Transgenic constructs containing regulatory region of pll

Aberrations (Deficiencies and Duplications) ( 18 )

Inferred from experimentation

Gene not disrupted in

Df(3R)IR25

(Shelton and Wasserman, 1993)

Df(3R)Tl-X

(Tearle and Nusslein-Volhard, 1987)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | maternal effect

lethal | maternal effect | cold sensitive

lethal | maternal effect | heat sensitive

pll¹⁵

lethal | maternal effect | recessive

lethal | maternal effect | recessive | cold sensitive

lethal - all die during embryonic stage | germline clone | non-rescuable maternal effect | recessive

viable

pll^e01040

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

pll^GD1286

viable, with Scer\GAL4^Mef2.PR

pll^GD1286

viable, with Scer\GAL4^pnr-MD237

pll^GD1286

viable, with Scer\GAL4^tin.CΔ4

pll^GD1286

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

pll^HMS04458

female sterile | recessive

pll¹

fertile

pll^e01040

Other Phenotypes

Allele

abnormal neuroanatomy (with pll²)

pll⁷

abnormal neuroanatomy (with pll⁷)

abnormal neuroanatomy (with pll²⁵)

pll⁷

abnormal size | embryonic stage

pll⁷

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

pll^GD1286

some die during embryonic stage | non-rescuable maternal effect | recessive

Phenotype manifest in

Allele

axon & eye photoreceptor cell (with pll²)

pll⁷

axon & eye photoreceptor cell (with pll⁷)

axon & eye photoreceptor cell (with pll²⁵)

pll⁷

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

pll^HMS04458

embryo | ventral

pll^unspecified

embryonic/larval hemolymph (with pll²)

pll¹⁰

embryonic/larval hemolymph (with pll¹⁰)

pll²

embryonic/larval somatic muscle

embryonic ventral epidermis

pll⁷

filzkorper

pll⁷

hemocyte | larval stage (with pll²)

pll¹⁰

hemocyte | larval stage (with pll¹⁰)

pll²

lamina (with pll²)

pll⁷

lamina (with pll⁷)

lamina (with pll²⁵)

pll⁷

macrochaeta

pll⁷

medulla (with pll²)

pll⁷

medulla (with pll⁷)

medulla (with pll²⁵)

pll⁷

posterior spiracle primordium

pll⁷

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\IRAK4

9 of 15

Yes

Hsap\IRAK1

8 of 15

Yes

Hsap\IRAK2

7 of 15

Yes

Hsap\IRAK3

5 of 15

Yes

Hsap\ANKK1

1 of 15

Yes

Hsap\LIMK1

1 of 15

Hsap\LIMK2

1 of 15

Hsap\MIR718

1 of 15

Yes

Hsap\MIR6502

1 of 15

Yes

Hsap\PKDCC

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Irak4

10 of 15

Yes

Mmus\Irak1

8 of 15

Yes

Mmus\Irak3

6 of 15

Yes

Mmus\Irak2

4 of 15

Yes

Mmus\Ankk1

1 of 15

Yes

Mmus\Limk1

1 of 15

Mmus\Limk2

1 of 15

Mmus\Pkdcc

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (8)

Rnor\Irak4

8 of 13

Yes

Rnor\Irak3

6 of 13

Yes

Rnor\Irak1

5 of 13

Yes

Rnor\Irak2

5 of 13

Yes

Rnor\Limk2

1 of 13

Rnor\Pkdcc

1 of 13

Yes

Rnor\Ripk1

1 of 13

Rnor\Ripk3

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\irak2

6 of 12

Yes

Xtro\irak4

6 of 12

Yes

Xtro\irak1

5 of 12

Yes

Xtro\ankk1

1 of 12

Yes

Xtro\limk1

1 of 12

Xtro\limk2

1 of 12

Xtro\LOC100490493

1 of 12

Yes

Xtro\pkdcc.1

1 of 12

Yes

Xtro\pkdcc.2

1 of 12

Yes

Xtro\ripk4

1 of 12

Yes

Danio rerio (Zebrafish) (12)

Drer\irak1

8 of 15

Yes

Drer\irak3

7 of 15

Yes

Drer\irak4

5 of 15

Yes

Drer\ankk1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\pkdccb

1 of 15

Yes

Drer\ripk2

1 of 15

Drer\ripk3

1 of 15

Drer\ripk4

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\pik-1

14 of 15

Yes

Arabidopsis thaliana (thale-cress) (273)

Atha\AT1G16260

2 of 9

Yes

Atha\AT1G76360

2 of 9

Yes

Atha\AT2G16750

2 of 9

Yes

Atha\AT3G01300

2 of 9

Yes

Atha\AT4G02010

2 of 9

Yes

Atha\AT4G35030

2 of 9

Yes

Atha\AT5G59680

2 of 9

Yes

Atha\GPK1

2 of 9

Yes

Atha\ALE2

1 of 9

Yes

Atha\ANX1

1 of 9

Yes

Atha\ANX2

1 of 9

Yes

Atha\APK2A

1 of 9

Yes

Atha\APK2B

1 of 9

Yes

Atha\ASG5

1 of 9

Yes

Atha\AT1G05700

1 of 9

Yes

Atha\AT1G07550

1 of 9

Yes

Atha\AT1G07560

1 of 9

Yes

Atha\AT1G07870

1 of 9

Yes

Atha\AT1G09440

1 of 9

Yes

Atha\AT1G11050

1 of 9

Yes

Atha\AT1G11330

1 of 9

Yes

Atha\AT1G15530

1 of 9

Yes

Atha\AT1G17910

1 of 9

Yes

Atha\AT1G18390

1 of 9

Yes

Atha\AT1G19390

1 of 9

Yes

Atha\AT1G21590

1 of 9

Yes

Atha\AT1G24030

1 of 9

Yes

Atha\AT1G24650

1 of 9

Yes

Atha\AT1G25390

1 of 9

Yes

Atha\AT1G29720

1 of 9

Yes

Atha\AT1G29730

1 of 9

Yes

Atha\AT1G29740

1 of 9

Yes

Atha\AT1G49100

1 of 9

Yes

Atha\AT1G51790

1 of 9

Yes

Atha\AT1G51805

1 of 9

Yes

Atha\AT1G51810

1 of 9

Yes

Atha\AT1G51820

1 of 9

Yes

Atha\AT1G51830

1 of 9

Yes

Atha\AT1G51850

1 of 9

Yes

Atha\AT1G51860

1 of 9

Yes

Atha\AT1G51870

1 of 9

Yes

Atha\AT1G51890

1 of 9

Yes

Atha\AT1G51910

1 of 9

Yes

Atha\AT1G52310

1 of 9

Yes

Atha\AT1G52540

1 of 9

Yes

Atha\AT1G54820

1 of 9

Yes

Atha\AT1G55200

1 of 9

Yes

Atha\AT1G56720

1 of 9

Yes

Atha\AT1G61590

1 of 9

Yes

Atha\AT1G66880

1 of 9

Yes

Atha\AT1G67720

1 of 9

Yes

Atha\AT1G69730

1 of 9

Yes

Atha\AT1G69910

1 of 9

Yes

Atha\AT1G70110

1 of 9

Yes

Atha\AT1G70130

1 of 9

Yes

Atha\AT1G70740

1 of 9

Yes

Atha\AT1G72760

1 of 9

Yes

Atha\AT1G77280

1 of 9

Yes

Atha\AT1G80640

1 of 9

Yes

Atha\AT2G01820

1 of 9

Yes

Atha\AT2G04300

1 of 9

Yes

Atha\AT2G14440

1 of 9

Yes

Atha\AT2G14510

1 of 9

Yes

Atha\AT2G19210

1 of 9

Yes

Atha\AT2G19230

1 of 9

Yes

Atha\AT2G21480

1 of 9

Yes

Atha\AT2G23200

1 of 9

Yes

Atha\AT2G23450

1 of 9

Yes

Atha\AT2G25220

1 of 9

Yes

Atha\AT2G26730

1 of 9

Yes

Atha\AT2G28590

1 of 9

Yes

Atha\AT2G28940

1 of 9

Yes

Atha\AT2G28960

1 of 9

Yes

Atha\AT2G28970

1 of 9

Yes

Atha\AT2G28990

1 of 9

Yes

Atha\AT2G29000

1 of 9

Yes

Atha\AT2G37050

1 of 9

Yes

Atha\AT2G39110

1 of 9

Yes

Atha\AT2G39360

1 of 9

Yes

Atha\AT2G41970

1 of 9

Yes

Atha\AT2G42960

1 of 9

Yes

Atha\AT2G43690

1 of 9

Yes

Atha\AT2G45590

1 of 9

Yes

Atha\AT3G02810

1 of 9

Yes

Atha\AT3G08870

1 of 9

Yes

Atha\AT3G09010

1 of 9

Yes

Atha\AT3G09830

1 of 9

Yes

Atha\AT3G13690

1 of 9

Yes

Atha\AT3G15890

1 of 9

Yes

Atha\AT3G20530

1 of 9

Yes

Atha\AT3G21340

1 of 9

Yes

Atha\AT3G23750

1 of 9

Yes

Atha\AT3G24790

1 of 9

Yes

Atha\AT3G25490

1 of 9

Yes

Atha\AT3G26700

1 of 9

Yes

Atha\AT3G28690

1 of 9

Yes

Atha\AT3G45330

1 of 9

Yes

Atha\AT3G45430

1 of 9

Yes

Atha\AT3G46340

1 of 9

Yes

Atha\AT3G46350

1 of 9

Yes

Atha\AT3G46355

1 of 9

Yes

Atha\AT3G46370

1 of 9

Yes

Atha\AT3G46400

1 of 9

Yes

Atha\AT3G46410

1 of 9

Yes

Atha\AT3G46420

1 of 9

Yes

Atha\AT3G53380

1 of 9

Yes

Atha\AT3G53810

1 of 9

Yes

Atha\AT3G53840

1 of 9

Yes

Atha\AT3G55550

1 of 9

Yes

Atha\AT3G57120

1 of 9

Yes

Atha\AT3G59110

1 of 9

Yes

Atha\AT3G59740

1 of 9

Yes

Atha\AT3G59750

1 of 9

Yes

Atha\AT4G00960

1 of 9

Yes

Atha\AT4G02410

1 of 9

Yes

Atha\AT4G02420

1 of 9

Yes

Atha\AT4G02630

1 of 9

Yes

Atha\AT4G04960

1 of 9

Yes

Atha\AT4G20450

1 of 9

Yes

Atha\AT4G25390

1 of 9

Yes

Atha\AT4G28350

1 of 9

Yes

Atha\AT4G28670

1 of 9

Yes

Atha\AT4G29050

1 of 9

Yes

Atha\AT4G29450

1 of 9

Yes

Atha\AT4G29990

1 of 9

Yes

Atha\AT4G31100

1 of 9

Yes

Atha\AT4G31110

1 of 9

Yes

Atha\AT4G32000

1 of 9

Yes

Atha\AT4G34500

1 of 9

Yes

Atha\AT4G39110

1 of 9

Yes

Atha\AT5G02070

1 of 9

Yes

Atha\AT5G03140

1 of 9

Yes

Atha\AT5G03320

1 of 9

Yes

Atha\AT5G06740

1 of 9

Yes

Atha\AT5G10530

1 of 9

Yes

Atha\AT5G11020

1 of 9

Yes

Atha\AT5G12000

1 of 9

Yes

Atha\AT5G15080

1 of 9

Yes

Atha\AT5G16500

1 of 9

Yes

Atha\AT5G16590

1 of 9

Yes

Atha\AT5G16900

1 of 9

Yes

Atha\AT5G18500

1 of 9

Yes

Atha\AT5G18610

1 of 9

Yes

Atha\AT5G24010

1 of 9

Yes

Atha\AT5G24100

1 of 9

Yes

Atha\AT5G35580

1 of 9

Yes

Atha\AT5G38210

1 of 9

Yes

Atha\AT5G38990

1 of 9

Yes

Atha\AT5G39000

1 of 9

Yes

Atha\AT5G39020

1 of 9

Yes

Atha\AT5G42120

1 of 9

Yes

Atha\AT5G42440

1 of 9

Yes

Atha\AT5G48740

1 of 9

Yes

Atha\AT5G51770

1 of 9

Yes

Atha\AT5G55830

1 of 9

Yes

Atha\AT5G56790

1 of 9

Yes

Atha\AT5G56890

1 of 9

Yes

Atha\AT5G57670

1 of 9

Yes

Atha\AT5G59270

1 of 9

Yes

Atha\AT5G59650

1 of 9

Yes

Atha\AT5G59660

1 of 9

Yes

Atha\AT5G59670

1 of 9

Yes

Atha\AT5G59700

1 of 9

Yes

Atha\AT5G60320

1 of 9

Yes

Atha\AT5G61350

1 of 9

Yes

Atha\AT5G61570

1 of 9

Yes

Atha\AT5G63940

1 of 9

Yes

Atha\AT5G65530

1 of 9

Yes

Atha\AT5G65600

1 of 9

Yes

Atha\AT5G66790

1 of 9

Yes

Atha\CDG1

1 of 9

Yes

Atha\CDL1

1 of 9

Yes

Atha\CERK1

1 of 9

Yes

Atha\CRCK1

1 of 9

Yes

Atha\CRCK2

1 of 9

Yes

Atha\CRCK3

1 of 9

Yes

Atha\CRK2

1 of 9

Yes

Atha\CRK3

1 of 9

Yes

Atha\CRK4

1 of 9

Yes

Atha\CRK5

1 of 9

Yes

Atha\CRK6

1 of 9

Yes

Atha\CRK7

1 of 9

Yes

Atha\CRK8

1 of 9

Yes

Atha\CRK10

1 of 9

Yes

Atha\CRK11

1 of 9

Yes

Atha\CRK12

1 of 9

Yes

Atha\CRK13

1 of 9

Yes

Atha\CRK14

1 of 9

Yes

Atha\CRK15

1 of 9

Yes

Atha\CRK16

1 of 9

Yes

Atha\CRK18

1 of 9

Yes

Atha\CRK19

1 of 9

Yes

Atha\CRK20

1 of 9

Yes

Atha\CRK21

1 of 9

Yes

Atha\CRK22

1 of 9

Yes

Atha\CRK23

1 of 9

Yes

Atha\CRK24

1 of 9

Yes

Atha\CRK25

1 of 9

Yes

Atha\CRK26

1 of 9

Yes

Atha\CRK27

1 of 9

Yes

Atha\CRK28

1 of 9

Yes

Atha\CRK29

1 of 9

Yes

Atha\CRK30

1 of 9

Yes

Atha\CRK31

1 of 9

Yes

Atha\CRK32

1 of 9

Yes

Atha\CRK33

1 of 9

Yes

Atha\CRK34

1 of 9

Yes

Atha\CRK36

1 of 9

Yes

Atha\CRK37

1 of 9

Yes

Atha\CRK38

1 of 9

Yes

Atha\CRK39

1 of 9

Yes

Atha\CRK40

1 of 9

Yes

Atha\CRK41

1 of 9

Yes

Atha\CRK42

1 of 9

Yes

Atha\CRLK1

1 of 9

Yes

Atha\CST

1 of 9

Yes

Atha\EMB1290

1 of 9

Yes

Atha\FER

1 of 9

Yes

Atha\FRK1

1 of 9

Yes

Atha\Haspin

1 of 9

Atha\HERK1

1 of 9

Yes

Atha\HERK2

1 of 9

Yes

Atha\HLECRK

1 of 9

Yes

Atha\IOS1

1 of 9

Yes

Atha\Kin3

1 of 9

Yes

Atha\LECRKA4.1

1 of 9

Yes

Atha\LECRKA4.2

1 of 9

Yes

Atha\LECRKA4.3

1 of 9

Yes

Atha\LecRK-I.9

1 of 9

Yes

Atha\MEE39

1 of 9

Yes

Atha\NCRK

1 of 9

Yes

Atha\PBL1

1 of 9

Yes

Atha\PBS1

1 of 9

Yes

Atha\PERK1

1 of 9

Yes

Atha\PERK3

1 of 9

Yes

Atha\PERK4

1 of 9

Yes

Atha\PERK5

1 of 9

Yes

Atha\PERK6

1 of 9

Yes

Atha\PERK7

1 of 9

Yes

Atha\PERK8

1 of 9

Yes

Atha\PERK9

1 of 9

Yes

Atha\PERK10

1 of 9

Yes

Atha\PERK11

1 of 9

Yes

Atha\PERK12

1 of 9

Yes

Atha\PERK13

1 of 9

Yes

Atha\PERK14

1 of 9

Yes

Atha\PERK15

1 of 9

Yes

Atha\RBK1

1 of 9

Yes

Atha\RFO1

1 of 9

Yes

Atha\RHS6

1 of 9

Yes

Atha\RHS16

1 of 9

Yes

Atha\RIPK

1 of 9

Yes

Atha\RKF2

1 of 9

Yes

Atha\RKF3

1 of 9

Yes

Atha\RLK

1 of 9

Yes

Atha\RPK1

1 of 9

Yes

Atha\SRF1

1 of 9

Yes

Atha\SRF3

1 of 9

Yes

Atha\SRF4

1 of 9

Yes

Atha\SRF5

1 of 9

Yes

Atha\SUB

1 of 9

Yes

Atha\THE1

1 of 9

Yes

Atha\WAK1

1 of 9

Yes

Atha\WAK2

1 of 9

Yes

Atha\WAK3

1 of 9

Yes

Atha\WAK4

1 of 9

Yes

Atha\WAK5

1 of 9

Yes

Atha\WAKL1

1 of 9

Yes

Atha\WAKL2

1 of 9

Yes

Atha\WAKL4

1 of 9

Yes

Atha\WAKL5

1 of 9

Yes

Atha\WAKL6

1 of 9

Yes

Atha\WAKL10

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ALK1

1 of 15

Yes

Scer\ALK2

1 of 15

Yes

Scer\KIN1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\hrk1

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906S3 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19272

Drosophila persimilis

Dper\GL23050

Drosophila willistoni

Dwil\GK22593

Drosophila virilis

Dvir\GJ10484

Drosophila mojavensis

Dmoj\GI22298

Drosophila grimshawi

Dgri\GH16651

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503RV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17006429

Glossina morsitans

Tsetse fly

Gmor\GMOY000628

Mayetiola destructor

Hessian fly

Mdes\Mdes014468

Mayetiola destructor

Hessian fly

Mdes\Mdes007467

Mayetiola destructor

Hessian fly

Mdes\Mdes016018

Anopheles darlingi

American malaria mosquito

Adar\ADAC003846

Anopheles gambiae

Malaria mosquito

Agam\PELLE

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ015141

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ015474

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07F7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000063

Danaus plexippus

Monarch butterfly

Dple\DPOGS210260-PA

Heliconius melpomene

Postman butterfly

Hmel\Pelle

Apis florea

Little honeybee

Aflo\2355231876

Apis mellifera

Western honey bee

Amel\GB49344

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24991

Bombus terrestris

Buff-tailed bumblebee

Bter\15206033

Linepithema humile

Argentine ant

Lhum\LH17362

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000a0a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG020171

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG021270

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06418

Tribolium castaneum

Red flour beetle

Tcas\pll

Pediculus humanus

Human body louse

Phum\PHUM518290

Rhodnius prolixus

Kissing bug

Rpro\RPRC005685

Cimex lectularius

Bed bug

Clec\CLEC003482

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009928

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09453

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07A7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014285

Ixodes scapularis

Black-legged tick

Isca\ISCW001463

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60879.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g00840

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g00880

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_331814

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08K9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pik2

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007925

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment