tyrosine kinase - Toll pathway - dorsal group - involved in signal transduction during induction of dorsal/ventral polarity during early embryogenesis - regulation of antimicrobial peptides.
Please see the GBrowse view of Dmel\pll or the JBrowse view of Dmel\pll for information on other features
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Gene model reviewed during 5.47
1.9 (northern blot)
501 (aa); 56 (kD)
Interacts (via Death domain) with tub (via Death domain). Interacts with Pellino (Pli).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pll using the Feature Mapper tool.
pll transcripts are expressed most strongly in early embryos and adult females and are observed at a lower level throughout development.
GBrowse - Visual display of RNA-Seq signals
View Dmel\pll in GBrowse 23-92
3-90.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in cytokinetic index is seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
pll is activated by autophosphorylation.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
pll is required for muscle development in the embryo.
Mutations that affect the synthesis of antimicrobial peptides dramatically lower the resistance of flies to infection.
Recessive dorsalizing mutants of the dorsal group gene pll have significantly reduced axial ratios in pupae.
Epistatic relationships exist between dorsalizing maternal effect mutations and "dppHin" alleles.
