FB2020_06, released Dec 22, 2020

Gene: Dmel\Wnt4

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General Information
Symbol
Dmel\Wnt4
Species
D. melanogaster
Name
Wnt oncogene analog 4
Annotation Symbol
CG4698
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010453
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

DWnt4, DWnt-4, Wnt-4

Key Links
Genomic Location
Cytogenetic map
27E7-27E8
Sequence location
2L:7,255,419..7,277,171 [-]
Recombination map

2-25

RefSeq locus
NT_033779 REGION:7255419..7277171
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables frizzled binding
inferred from physical interaction with FLYBASE:fz; FB:FBgn0001085, FLYBASE:fz2; FB:FBgn0016797, FLYBASE:fz4; FB:FBgn0027342
(Wu and Nusse, 2002)
enables protein binding
inferred from physical interaction with FLYBASE:fj; FB:FBgn0000658
(Lim et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables cytokine activity
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
(Gaudet et al., 2011)
enables frizzled binding
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
(Gaudet et al., 2011)
enables signaling receptor binding
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
(FlyBase Curators, 2008--)
Biological Process (14 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in cell migration
inferred from mutant phenotype
(assigned by UniProt )
(Cohen et al., 2002)
involved_in establishment of planar polarity
inferred from genetic interaction with FLYBASE:fj; FB:FBgn0000658
(Lim et al., 2005)
involved_in female gonad development
inferred from mutant phenotype
(assigned by UniProt )
(Cohen et al., 2002)
involved_in germ-line stem-cell niche homeostasis
inferred from mutant phenotype
(Wang et al., 2015)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Inaki et al., 2007)
involved_in non-canonical Wnt signaling pathway
inferred from mutant phenotype
(Sato et al., 2006)
involved_in regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
involved_in retinal ganglion cell axon guidance
inferred from mutant phenotype
(Sato et al., 2006)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Harris and Beckendorf, 2007)
involved_in synaptic target inhibition
inferred from mutant phenotype
(Inaki et al., 2007)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cell fate commitment
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Wnt signaling pathway
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
(FlyBase Curators, 2008--, Graba et al., 1995)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cell surface
inferred from direct assay
(Sato et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in extracellular region
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
(FlyBase Curators, 2008--)
inferred from sequence model
(Graba et al., 1995)
non-traceable author statement
(assigned by UniProt )
(Cohen et al., 2002)
located_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Wnt family. (P40589)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
WNTs -
WNTs are evolutionarily conserved secreted Cys-rich glycoproteins, defined by sequence homology to the original members of the family - Wnt1 in mouse and wingless (wg) in Drosophila. They are extracellular ligands for members of the Frizzled family of receptors as well as other receptors. (Adapted from PMID:23151663).
Protein Function (UniProtKB)
Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis.
(UniProt, P40589)
Summary (Interactive Fly)

ligand - Wnt homolog - mesodermal - a Wingless antagonist - transposon dysregulation modulates Wnt4 signaling to control germline stem cell differentiation

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Wnt4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Wnt4-RA
FBtr0089291
NM_057624
3367
539
Wnt4-RB
FBtr0334799
NM_001273258
2938
539
Additional Transcript Data and Comments
Reported size (kB)

3.2 (northern blot)

(Graba et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Wnt4-PA
FBpp0088345
58.7
539
9.29
NP_476972
AAF52499
Wnt4-PB
FBpp0306845
58.7
539
9.29
NP_001260187
AGB92723
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

539 aa isoforms: Wnt4-PA, Wnt4-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

389 (aa)

(Graba et al., 1995)
Comments
External Data
Post Translational Modification

Palmitoleoylated by porcupine. The lipid group functions as a sorting signal, targeting the ligand to polarized vesicles that transport Wnt4 to unique sites at the cell surface. Depalmitoleoylated by notum, leading to inhibit Wnt signaling pathway.

(UniProt, P40589)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wnt4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Graba et al., 1995)
presumptive embryonic/larval central nervous system
(Graba et al., 1995)
ectoderm
(Graba et al., 1995)
embryonic stage 16
gastric caecum
(Graba et al., 1995)
embryonic midgut constriction 2
(Graba et al., 1995)
embryonic/larval heart
(Tauc et al., 2012)
ventral longitudinal muscle 1 | restricted
(Inaki et al., 2007)
A1-7 ventral longitudinal muscle 2 | restricted
(Inaki et al., 2007)
embryonic/larval ostium
(Chen et al., 2016)
embryonic stage 8 -- 11
organism | segment polarity expression pattern
(Graba et al., 1995)
embryonic stage 14
embryonic/larval foregut
(Graba et al., 1995)
parasegment 4 of visceral mesoderm
(Graba et al., 1995)
parasegment 8 of visceral mesoderm
(Graba et al., 1995)
embryonic/larval hindgut
(Graba et al., 1995)
embryonic stage 11
organism | segmentally repeated
(Sato et al., 1999)
parasegment 4 of visceral mesoderm
(Sato et al., 1999)
ventral nerve cord
(Sato et al., 1999)
head segment | segmentally repeated
(Buratovich et al., 2000)
epidermis | segmentally repeated | ventral
(Buratovich et al., 2000)
visceral mesoderm
(Chen et al., 2016)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic ganglion mother cell
(Fisher et al., 2012)
embryonic inner optic lobe primordium
(Fisher et al., 2012)
embryonic leading edge cell primordium

Comment: reported as embryonic leading edge cell specific anlage

(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
gnathal primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
longitudinal visceral muscle primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic anal pad
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic rectum
(Fisher et al., 2012)
embryonic small intestine
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
gastric caecum
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
embryonic inner optic lobe primordium
(Fisher et al., 2012)
embryonic heart cardioblast
(Chen et al., 2016)
embryonic ostial cardioblast
(Chen et al., 2016)
embryonic stage 10
cardiogenic mesoderm | dorsal | uniform
(Tauc et al., 2012)
embryonic stage 11 -- 13
dorsal ectoderm | segmentally repeated
(Tauc et al., 2012)
embryonic stage 15 -- 17
embryonic cardioblast
(Tauc et al., 2012)
embryonic stage 16 -- 17
embryonic/larval pericardial cell
(Tauc et al., 2012)
embryonic stage 13
embryonic/larval heart
(Chen et al., 2016)
abdominal dorsal muscle
(Chen et al., 2016)
Additional Descriptive Data

Wnt4 is expressed in visceral mesoderm at embryonic stage 11. At stage 13, after cardioblasts are specified, transcripts can be detected at a low level in cardioblasts and at high levels in certain posterior segment dorsal muscles. Wnt4 expression becomes stronger in the cardioblasts at stage 15, with higher expression levels in the posterior segments. Expression in the posterior three pairs of ostia progenitors increases dramatically just before ostia formation starts. Wnt4 expression increases progressively from anterior to posterior with the highest expression in the posterior-most pairs of ostia cells. At stage 16, Wnt4 expression is highest in the ostia cells and at low levels in non-ostia cardioblasts.

(Chen et al., 2016)

At embryonic stage 10, Wnt4 transcript is expressed in a continuous band along the dorsal side of the embryo, where heart progenitors are are specified. Wnt4 transcript is present in both the ectoderm and mesoderm at this stage. From embryonic stage 11, ectodermal expression becomes segmented, and is localized on the anterior side of en stripes; mesodermal expression is undetectable. Starting at stage 15, Wnt4 transcript is expressed myocardial cells, and stage 16 is more pronounced in the posterior region of the dorsal vessel. At the end of embryogenesis, Wnt4 transcript is expressed in mycardial and pericardial cells.

(Tauc et al., 2012)

Wnt4 transcripts are first detected in stage 8 embryos where they appear at the anterior tip and in a segment polarity pattern along the trunk. 15 stripes are observed in the posteriormost cells of each parasegment. They are one cell wide and overlap the ventralmost wg cells. Shortly after, expression is seen in the foregut primordium and in dorsal patches that are thought to correspond to cells of the labral and ocular segment primordia. By stage 14, transcripts are visible in the CNS and the developing gut. CNS expression is not uniform but increases, progressively from anterior to posterior regions of the embryo. In the gut, transcripts are seen in the foregut, hindgut, and in two regions of the visceral mesoderm corresponding to parasegments 4 and 8. The latter two sites correspond to the primordia of the gastric caeca and the second midgut constriction.

(Graba et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
germarium region 2
(Cohen et al., 2002)
germarium region 1
(Cohen et al., 2002)
ovarian sheath
(Cohen et al., 2002)
germarium cap cell
(Cohen et al., 2002)
pupal stage
ovarian sheath
(Cohen et al., 2002)
Additional Descriptive Data

A 2 h after pupal formation (APF) protein is detected in the apical cells as they migrate basally. At 16 h APF Wnt4-expressing cells have migrated between the terminal filaments and developing germaria. At 18 h APF these cells have moved between individual basal stalk clusters. Expression is detected in sheath, basal half of the terminal filament cells and regions I and II of the germarium in the adult.

(Cohen et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell surface
inferred from direct assay
(Sato et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Wnt4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Wnt4
Transgenic constructs containing regulatory region of Wnt4
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2L)BSC324)
lethal | heat sensitive, with Scer\GAL4ptc-559.1
lethal - all die before end of P-stage, with Scer\GAL4ptc-559.1
partially lethal
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
sterile | recessive
Other Phenotypes
Allele
cell migration defective
cell shape defective
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4NP6099
neuroanatomy defective (with Wnt4C1)
neuroanatomy defective (with Wnt4EMS23)
neuroanatomy defective (with Wnt4P23)
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
planar polarity defective, with Scer\GAL4dpp.blk1
planar polarity defective, with Scer\GAL4ptc-559.1
planar polarity defective (with Df(2L)spdj2)
planar polarity defective | somatic clone, with Scer\GAL4Act5C.PP
some die during larval stage | recessive
some die during pharate adult stage, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4ptc-559.1
visible | heat sensitive (with Df(2L)spdj2)
Phenotype manifest in
Allele
alula | ectopic | heat sensitive, with Scer\GAL4ptc-559.1
anterior crossvein, with Scer\GAL4dpp.blk1
anterior crossvein, with Scer\GAL4ptc-559.1
denticle | ectopic, with Scer\GAL4arm.PS
denticle | ectopic, with Scer\GAL4da.G32
denticle belt | ectopic, with Scer\GAL4da.G32
dorsal denticle, with Scer\GAL4da.G32
dorsocentral bristle | supernumerary, with Scer\GAL4ptc-559.1
egg chamber
embryonic/first instar larval cuticle, with Scer\GAL4da.G32
embryonic/larval heart, with Scer\GAL4HCH.Hand
embryonic/larval heart (with Df(2L)BSC226)
embryonic/larval heart | embryonic stage 14
embryonic/larval optic stalk (with Wnt4C1)
embryonic/larval optic stalk (with Wnt4EMS23)
embryonic/larval ostium
embryonic/larval ostium, with Scer\GAL4HCH.Hand
embryonic/larval ostium (with Df(2L)BSC226)
embryonic cardioblast, with Scer\GAL4HCH.Hand
embryonic cardioblast (with Df(2L)BSC226)
embryonic cardioblast | embryonic stage 14
embryonic epidermis | dorsal, with Scer\GAL4da.G32
embryonic somatic muscle
embryonic ventral epidermis, with Scer\GAL4arm.PS
eye equator | heat sensitive (with Df(2L)spdj2)
eye photoreceptor cell
eye photoreceptor cell, with Scer\GAL4NP6099
eye photoreceptor cell (with Df(2L)spdj2)
eye photoreceptor cell (with Wnt4C1)
eye photoreceptor cell (with Wnt4EMS23)
eye photoreceptor cell (with Wnt4P23)
eye ventral compartment (with Df(2L)spdj2)
germarium
haltere | ectopic | heat sensitive, with Scer\GAL4ptc-559.1
lamina
lamina, with Scer\GAL4NP6099
lamina (with Wnt4C1)
lamina (with Wnt4EMS23)
lamina (with Wnt4P23)
mesothoracic tergum | heat sensitive, with Scer\GAL4ptc-559.1
neuron
neuron, with Scer\GAL4NP6099
neuron (with Wnt4C1)
neuron (with Wnt4EMS23)
neuron (with Wnt4P23)
ommatidium (with Df(2L)spdj2)
ovarian sheath
ovariole
ovary
posterior postalar bristle | supernumerary, with Scer\GAL4ptc-559.1
presumptive embryonic salivary gland
presumptive embryonic salivary gland, with Scer\GAL4bap.3
scutellar bristle | supernumerary, with Scer\GAL4ptc-559.1
scutellum | heat sensitive, with Scer\GAL4ptc-559.1
sternopleural bristle | supernumerary, with Scer\GAL4ptc-559.1
wing, with Scer\GAL4ptc-559.1
wing (with Df(2L)spdj2)
wing | ectopic | heat sensitive, with Scer\GAL4ptc-559.1
wing disc | heat sensitive, with Scer\GAL4ptc-559.1
wing hair, with Scer\GAL4dpp.blk1
wing hair, with Scer\GAL4en-e16E
wing hair, with Scer\GAL4ptc-559.1
wing hair | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP
wing margin bristle | ectopic | heat sensitive, with Scer\GAL4ptc-559.1
wing sensillum | ectopic | heat sensitive, with Scer\GAL4ptc-559.1
wing vein | ectopic (with Df(2L)spdj2)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\WNT9B
6 of 15
Yes
Yes
1  
Hsap\WNT9A
4 of 15
No
Yes
1  
Hsap\WNT1
3 of 15
No
No
1  
Hsap\WNT11
3 of 15
No
Yes
Hsap\WNT2B
2 of 15
No
No
Hsap\WNT2
2 of 15
No
No
Hsap\WNT6
2 of 15
No
No
Hsap\WNT16
2 of 15
No
No
Hsap\WNT3A
1 of 15
No
No
Hsap\WNT3
1 of 15
No
No
Hsap\WNT4
1 of 15
No
No
Hsap\WNT5A
1 of 15
No
No
Hsap\WNT5B
1 of 15
No
No
Hsap\WNT7A
1 of 15
No
No
1  
Hsap\WNT7B
1 of 15
No
No
1  
Hsap\WNT8A
1 of 15
No
No
Hsap\WNT8B
1 of 15
No
No
Hsap\WNT10A
1 of 15
No
No
1  
Hsap\WNT10B
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Wnt9b
6 of 15
Yes
Yes
Mmus\Wnt9a
4 of 15
No
Yes
Mmus\Wnt1
3 of 15
No
No
Mmus\Wnt11
3 of 15
No
Yes
Mmus\Wnt2b
2 of 15
No
No
Mmus\Wnt2
2 of 15
No
No
Mmus\Wnt6
2 of 15
No
No
Mmus\Wnt16
2 of 15
No
No
Mmus\Wnt3a
1 of 15
No
No
Mmus\Wnt3
1 of 15
No
No
Mmus\Wnt4
1 of 15
No
No
Mmus\Wnt5a
1 of 15
No
No
Mmus\Wnt5b
1 of 15
No
No
Mmus\Wnt7a
1 of 15
No
No
Mmus\Wnt7b
1 of 15
No
No
Mmus\Wnt8a
1 of 15
No
No
Mmus\Wnt8b
1 of 15
No
No
Mmus\Wnt10a
1 of 15
No
No
Mmus\Wnt10b
1 of 15
No
No
Rattus norvegicus (Norway rat) (16)
Rnor\Wnt9b
6 of 13
Yes
Yes
Rnor\Wnt11
3 of 13
No
Yes
Rnor\Wnt2b
2 of 13
No
No
Rnor\Wnt6
2 of 13
No
No
Rnor\Wnt9a
2 of 13
No
Yes
Rnor\Wnt16
2 of 13
No
Yes
Rnor\Wnt1
1 of 13
No
No
Rnor\Wnt3a
1 of 13
No
No
Rnor\Wnt3
1 of 13
No
No
Rnor\Wnt4
1 of 13
No
No
Rnor\Wnt5a
1 of 13
No
No
Rnor\Wnt5b
1 of 13
No
No
Rnor\Wnt7a
1 of 13
No
No
Rnor\Wnt7b
1 of 13
No
No
Rnor\Wnt8a
1 of 13
No
No
Rnor\Wnt8b
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
Xtro\wnt1
3 of 12
Yes
No
Xtro\wnt9b.2
3 of 12
Yes
Yes
Xtro\wnt9b
3 of 12
Yes
Yes
Xtro\wnt11b
3 of 12
Yes
Yes
Xtro\wnt11
3 of 12
Yes
Yes
Xtro\wnt2b
2 of 12
No
No
Xtro\wnt16
2 of 12
No
No
Xtro\LOC100497917
1 of 12
No
No
Xtro\wnt3a
1 of 12
No
No
Xtro\wnt4
1 of 12
No
No
Xtro\wnt5b
1 of 12
No
No
Xtro\wnt6
1 of 12
No
Yes
Xtro\wnt7b
1 of 12
No
No
Xtro\wnt7c
1 of 12
No
No
Xtro\wnt8a
1 of 12
No
No
Xtro\wnt8b
1 of 12
No
No
Xtro\wnt9a
1 of 12
No
Yes
Xtro\wnt10b
1 of 12
No
No
Xtro\wnt11
1 of 12
No
Yes
Danio rerio (Zebrafish) (24)
Drer\wnt9b
5 of 15
Yes
Yes
Drer\wnt1
3 of 15
No
No
Drer\wnt9a
3 of 15
No
Yes
Drer\wnt11
3 of 15
No
Yes
Drer\wnt11r
3 of 15
No
Yes
Drer\wnt2ba
2 of 15
No
No
Drer\wnt2bb
2 of 15
No
No
Drer\wnt2
2 of 15
No
No
Drer\wnt6a
2 of 15
No
No
Drer\wnt6b
2 of 15
No
No
Drer\wnt16
2 of 15
No
No
Drer\LOC568110
1 of 15
No
No
Drer\wnt3a
1 of 15
No
No
Drer\wnt3
1 of 15
No
Yes
Drer\wnt4b
1 of 15
No
No
Drer\wnt4
1 of 15
No
No
Drer\wnt5a
1 of 15
No
No
Drer\wnt7aa
1 of 15
No
No
Drer\wnt7ba
1 of 15
No
No
Drer\wnt8-2
1 of 15
No
No
Drer\wnt8a
1 of 15
No
No
Drer\wnt8b
1 of 15
No
No
Drer\wnt10a
1 of 15
No
No
Drer\wnt10b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\egl-20
2 of 15
Yes
No
Cele\lin-44
2 of 15
Yes
Yes
Cele\mom-2
2 of 15
Yes
No
Cele\cwn-1
1 of 15
No
No
Cele\cwn-2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907QX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001498
Drosophila simulans
Dsim\GD22501
Drosophila sechellia
Dsec\GM13583
Drosophila erecta
Dere\GG23540
Drosophila yakuba
Dyak\GE18366
Drosophila ananassae
Dana\GF14030
Drosophila pseudoobscura pseudoobscura
Dpse\GA25881
Drosophila persimilis
Dper\GL19231
Drosophila willistoni
Dwil\GK24728
Drosophila virilis
Dvir\GJ17616
Drosophila mojavensis
Dmoj\GI17793
Drosophila grimshawi
Dgri\GH13151
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506CU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17005375
Musca domestica
House fly
Mdoa\17005449
Glossina morsitans
Tsetse fly
Gmor\GMOY006806
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10356
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000632
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010739
Anopheles darlingi
American malaria mosquito
Adar\ADAC005728
Anopheles gambiae
Malaria mosquito
Agam\AGAP009735
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005836
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F8R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006145
Danaus plexippus
Monarch butterfly
Dple\DPOGS214086-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011441
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00568
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00567
Tribolium castaneum
Red flour beetle
Tcas\Wnt9
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03611
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OFF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-WntA_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wnt3
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002145
Ciona intestinalis
Vase tunicate
Cint\LOC778938
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000407
Ciona intestinalis
Vase tunicate
Cint\LOC778723
Ciona intestinalis
Vase tunicate
Cint\LOC778792
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009599
Gallus gallus
Domestic chicken
Ggal\WNT7B
Gallus gallus
Domestic chicken
Ggal\Gga.47682
Gallus gallus
Domestic chicken
Ggal\WNT3A
Gallus gallus
Domestic chicken
Ggal\WNT4
Gallus gallus
Domestic chicken
Ggal\WNT2B
Gallus gallus
Domestic chicken
Ggal\WNT9B
Gallus gallus
Domestic chicken
Ggal\WNT9a
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028069
Gallus gallus
Domestic chicken
Ggal\WNT11
Gallus gallus
Domestic chicken
Ggal\WNT7A
Gallus gallus
Domestic chicken
Ggal\WNT5A
Gallus gallus
Domestic chicken
Ggal\WNT5B
Gallus gallus
Domestic chicken
Ggal\WNT3
Gallus gallus
Domestic chicken
Ggal\WNT6
Gallus gallus
Domestic chicken
Ggal\WNT10A
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
wg
4 of 10
Wnt6
4 of 10
Wnt2
3 of 10
Wnt5
3 of 10
Wnt10
3 of 10
wntD
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WNT9B; Wnt family member 9B
    6 of 15
    602864
         
        WNT9A; Wnt family member 9A
        4 of 15
        602863
             
            WNT1; Wnt family member 1
            3 of 15
            164820
             
            WNT11; Wnt family member 11
            3 of 15
            603699
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Wnt4
                enhanceable
                hep
                (Sato et al., 2006)
                Wnt4
                enhanceable
                Wnt5
                (Harris and Beckendorf, 2007)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                fj
                enhanceable
                Wnt4
                (Lim et al., 2005)
                fz
                suppressible
                Wnt4
                (Lim et al., 2005)
                hep
                enhanceable
                Wnt4
                (Sato et al., 2006)
                hh
                suppressible
                Wnt4
                (Buratovich et al., 2000)
                wg
                suppressible
                Wnt4
                (Gieseler et al., 2001)
                Wnt5
                enhanceable
                Wnt4
                (Harris and Beckendorf, 2007)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map

                2-25

                Cytogenetic map
                27E7-27E8
                Sequence location
                2L:7,255,419..7,277,171 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                27E7-27E8
                Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                27F-28A
                (determined by in situ hybridisation)
                (Gieseler et al., 1995)
                Experimentally Determined Recombination Data
                Location

                2-25

                (FlyBase, 2016)

                2-23.9

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes

                Maps close to wg.

                (Graba et al., 1995)
                Stocks and Reagents
                Stocks (17)
                Genomic Clones (29)
                cDNA Clones (189)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Cohen et al., 2002)
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: Wnt4 CG4698

                (Deng, 1999.11)
                Source for database merge of
                Additional comments
                Other Comments

                Wnt4 is required for normal salivary gland migration in the embryo. It is required in the second phase of salivary gland migration, as the gland moves posteriorly within the embryo.

                (Harris and Beckendorf, 2007)

                Wnt4 regulates the dorsoventral specificity of retinal projections.

                (Sato et al., 2006)

                Wnt4 is required for cell movement and Fak56D regulation during ovarian morphogenesis. Wnt4 facilitates cell motility through regulation of focal adhesions.

                (Cohen et al., 2002)

                Wnt4 and wg produce distinct responses in cells of the dorsal embryonic epidermis. wg acts independently of hh signaling, while Wnt4 requires hh to elicit its effects.

                (Buratovich et al., 2000)

                Wnt4 has the capacity to antagonise wg signalling in the embryonic ventral epidermis.

                (Gieseler et al., 1999)

                wg and Wnt4 have partially overlapping embryonic expression patterns. Expression is regulated by HOM-C genes in the visceral mesoderm and segment polarity genes in the ectoderm. wg and Wnt4 achieve opposite, but complementary functions in intrasegmental cell patterning of the embryonic ectoderm.

                (Gieseler et al., 1995)

                Wnt4 has been characterised, Wnt4 gene product has a segment polarity-like expression pattern in the ectoderm and is controlled by homeotic complex (HOM-C) genes in the visceral mesoderm.

                (Graba et al., 1995)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 40 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Synonyms and Secondary IDs (16)
                Reported As
                Symbol Synonym
                CG4698
                (McEachern et al., 2014, Schertel et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009)
                DWnt-4
                (Chen et al., 2008, Pandur et al., 2002, Cohen and Wilder, 2001, Cohen et al., 2001, Logan et al., 2001, Buratovich et al., 2000, Cohen et al., 2000, Wilder and Wallace, 2000, Wilder and Wallace, 2000, Buratovich and Wilder, 1999, Gieseler et al., 1999, Wilder et al., 1999, Buratovich and Wilder, 1998, Perrimon and Nusse, 1998, Cadigan and Nusse, 1997, Graba et al., 1997, Wilder et al., 1997, Wilder et al., 1997, Graba et al., 1995)
                DWnt4
                (Yu et al., 2020, Port et al., 2008, Coudreuse and Korswagen, 2007, Sato et al., 2006, Lim et al., 2005, Sato et al., 2005, Gupta and Schupbach, 2003, Cadigan, 2002, Cohen and Wilder, 2002, Cohen et al., 2002, Peifer and McEwen, 2002, Wu and Nusse, 2002, Gieseler et al., 2001, Llimargas and Lawrence, 2001, Cox et al., 2000, Rizkalla and Siegfried, 2000, Reifegerste and Moses, 1999, Sato et al., 1999, Mariol et al., 1997, Gieseler et al., 1995, Gieseler et al., 1995, Mariol et al., 1995)
                Dm DWnt4
                (Konikoff et al., 2010)
                Dwnt-4
                (Swarup and Verheyen, 2012)
                Dwnt4
                (Perochon et al., 2018, Joshi et al., 2007, Bovolenta et al., 2006, Terry et al., 2006, Huang and Klein, 2004, Cadigan et al., 2002, Taylor, 2000)
                WNT4
                (Harris et al., 2016)
                Wnt
                (Blair, 1999)
                Wnt-4
                (Bajpai et al., 2004, Jockusch and Ober, 2000, Wehrli and Tomlinson, 1998)
                Wnt4
                (Cui et al., 2020, Slaidina et al., 2020, Tu et al., 2020, Waghmare et al., 2020, Zhang and Cai, 2020, Hall et al., 2019, Story et al., 2019, Wu et al., 2019, Cho et al., 2018, Jankovics et al., 2018, Ripp et al., 2018, Tian et al., 2018, Waghmare and Page-McCaw, 2018, Hessinger et al., 2017, Transgenic RNAi Project members, 2017-, Chen et al., 2016, Dominguez et al., 2016, Gene Disruption Project members, 2016-, Mottier-Pavie et al., 2016, Hamada-Kawaguchi et al., 2014, Kerr et al., 2014, Linnemannstöns et al., 2014, Toshima et al., 2014, Schertel et al., 2013, Sopko and Perrimon, 2013, Webber et al., 2013, Wu et al., 2013, Herr and Basler, 2012, Japanese National Institute of Genetics, 2012.5.21, Kuroda et al., 2012, Lahaye et al., 2012, Nose, 2012, Cherbas et al., 2011, Peradziryi et al., 2011, Biehs et al., 2010, Bina et al., 2010, Inaki et al., 2010, Kong et al., 2010, Chen et al., 2008, Christensen and Cook, 2007.5.8, Christensen et al., 2007.10.29, Harris and Beckendorf, 2007, Inaki et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Casal et al., 2006, Christensen and Cook, 2006.12.5, Ma et al., 2006, Pearson et al., 2005)
                anon-EST:Liang-2.4
                clone 2.4
                (Liang and Biggin, 1998)
                dWnt4
                (Humphries and Mlodzik, 2018)
                wnt-4
                (Liang and Biggin, 1998)
                wnt4
                (Ewen-Campen et al., 2020, Mele and Johnson, 2019, Ewen-Campen et al., 2017, Khan et al., 2013, Sinenko et al., 2010, Srahna et al., 2006, Veeman et al., 2003, Bhat, 1999, Bhat, 1998)
                Name Synonyms
                Wnt oncogene analog 4
                (McEachern et al., 2014)
                Secondary FlyBase IDs
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (175)