FB2019_05, released Oct 15, 2019

Gene: Dmel\tutl

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General Information
Symbol
Dmel\tutl
Species
D. melanogaster
Name
turtle
Annotation Symbol
CG15427
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010473
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Snapshot
turtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
l(2)01085, jf4, mdcds_7441
Key Links
Genomic Location
Cytogenetic map
24E1-24E1
Sequence location
2L:4,283,148..4,323,781 [+]
Recombination map
2-12
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the immunoglobulin superfamily. Turtle family. (Q967D7)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
cell-cell adhesion mediator activity
Predictions / Assertions
cell-cell adhesion mediator activity
Summaries
Protein Function (UniProtKB)
Essential protein that plays a role in the establishment of coordinated motor control (PubMed:11312296). In the developing eye, involved in axonal targeting of the R7 photoreceptor (PubMed:24174674).
(UniProt, Q967D7)
Summary (Interactive Fly)
Ig superfamily - ligand or co-receptor - required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors - regulates the tiling pattern of R7 photoreceptor terminals
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
8

Please see the GBrowse view of Dmel\tutl or the JBrowse view of Dmel\tutl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.55
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Alternative translation stop created by use of multiphasic reading frames within coding region.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tutl-RA
FBtr0089268
NM_164578
1874
377
tutl-RC
FBtr0089269
NM_164577
4595
903
tutl-RD
FBtr0089270
NM_164576
5179
1508
tutl-RE
FBtr0089271
NM_080127
3388
902
tutl-RF
FBtr0301863
NM_001169397
5250
963
tutl-RG
FBtr0301864
NM_001169398
5127
1508
tutl-RH
FBtr0333484
NM_001273090
7436
1533
tutl-RI
FBtr0333485
NM_001273091
7798
963
tutl-RJ
FBtr0347158
NM_001316378
5263
1536
tutl-RK
FBtr0347159
NM_001316379
5334
991
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
tutl-PA
FBpp0088325
41.9
377
8.04
NP_722969
AAF51031
tutl-PC
FBpp0088326
100.4
903
8.12
NP_722968
AAF51030
tutl-PD
FBpp0088327
168.2
1508
9.05
NP_722967
AAF51029
tutl-PE
FBpp0088328
100.5
902
8.12
NP_524866
AAN11173
tutl-PF
FBpp0291077
107.4
963
8.16
NP_001162868
ACZ94159
tutl-PG
FBpp0291078
168.2
1508
9.05
NP_001162869
ACZ94160
tutl-PH
FBpp0305668
171.1
1533
9.21
NP_001260019
AGB92555
tutl-PI
FBpp0305669
107.4
963
8.16
NP_001260020
AGB92556
tutl-PJ
FBpp0312489
171.5
1536
9.08
NP_001303307
ALI30193
tutl-PK
FBpp0312490
110.7
991
8.24
NP_001303308
ALI30194
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1508 aa isoforms: tutl-PD, tutl-PG
963 aa isoforms: tutl-PF, tutl-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with bdl.
(UniProt, Q967D7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tutl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (16 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cell-cell adhesion mediator activity
inferred from physical interaction with FLYBASE:bdl; FB:FBgn0028482
(Cameron et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cell-cell adhesion mediator activity
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (12 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
adult locomotory behavior
inferred from mutant phenotype
(Bodily et al., 2001)
axon guidance
inferred from mutant phenotype
(Al-Anzi and Wyman, 2009)
axon midline choice point recognition
inferred from mutant phenotype
(Al-Anzi and Wyman, 2009)
axonal defasciculation
inferred from mutant phenotype
(Al-Anzi and Wyman, 2009)
dendrite self-avoidance
inferred from mutant phenotype
(Long et al., 2009)
flight behavior
inferred from mutant phenotype
(Bodily et al., 2001)
larval behavior
inferred from mutant phenotype
(Bodily et al., 2001)
mechanosensory behavior
inferred from mutant phenotype
(Zhou et al., 2012)
R7 cell development
inferred from mutant phenotype
(Cameron et al., 2013)
inferred from genetic interaction with FLYBASE:bdl; FB:FBgn0028482
(Cameron et al., 2013)
regulation of dendrite morphogenesis
inferred from mutant phenotype
(Long et al., 2009)
synaptic target recognition
inferred from mutant phenotype
(Kurusu et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
dendrite self-avoidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
homophilic cell adhesion via plasma membrane adhesion molecules
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
axon
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
integral component of plasma membrane
inferred by curator from GO:0098632
(Cameron et al., 2013)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 14
embryonic/larval salivary gland
(Al-Anzi and Wyman, 2009)
embryonic/larval digestive system
(Al-Anzi and Wyman, 2009)
embryonic/larval glial cell
(Al-Anzi and Wyman, 2009)
embryonic stage 13 -- 16
atrium
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral midline
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
third instar larval stage
morphogenetic furrow
(Al-Anzi and Wyman, 2009)
eye disc | restricted

Comment: isoform-specific expression

(Al-Anzi and Wyman, 2009)
embryonic/larval brain
(Al-Anzi and Wyman, 2009)
embryonic/larval optic lobe
(Al-Anzi and Wyman, 2009)
adult optic lobe & optic nerve

Comment: isoform-specific expression

(Al-Anzi and Wyman, 2009)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 13
ventral midline
(Al-Anzi and Wyman, 2009)
embryonic stage 14 -- 17
embryonic/larval central nervous system
(Al-Anzi and Wyman, 2009)
Additional Descriptive Data
tutl expression is observed in the embryonic central nervous system, salivary glands and gut as well as in larval eye disc and brain. Isoform-specific levels and expression patterns are described.
(Al-Anzi and Wyman, 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuropil | subset of embryonic/larval central nervous system
(Zhou et al., 2012)
larval dorsal multidendritic neuron ddaC
(Long et al., 2009)
larval dorsal multidendritic neuron ddaB
(Long et al., 2009)
larval dorsal multidendritic neuron ddaA
(Long et al., 2009)
larval dorsal multidendritic neuron ddaF
(Long et al., 2009)
larval dorsal multidendritic neuron ddaD
(Long et al., 2009)
larval dorsal multidendritic neuron ddaE
(Long et al., 2009)
class I dendritic arborizing neuron

Comment: weak

(Sulkowski et al., 2011, Long et al., 2009)
class II dendritic arborizing neuron

Comment: moderate

(Sulkowski et al., 2011, Long et al., 2009)
class III dendritic arborizing neuron

Comment: high

(Sulkowski et al., 2011, Long et al., 2009)
class IV dendritic arborizing neuron

Comment: high

(Sulkowski et al., 2011, Long et al., 2009)
pharate adult stage P8
lobula | restricted
(Ferguson et al., 2009)
lamina | restricted
(Ferguson et al., 2009)
adult optic lobe | restricted
(Ferguson et al., 2009)
pharate adult stage P9
lobula | restricted
(Ferguson et al., 2009)
lobula plate | restricted
(Ferguson et al., 2009)
lamina | restricted
(Ferguson et al., 2009)
adult optic lobe | restricted
(Ferguson et al., 2009)
adult stage
lobula | restricted
(Ferguson et al., 2009)
lobula plate | restricted
(Ferguson et al., 2009)
lamina | restricted
(Ferguson et al., 2009)
adult optic lobe | restricted
(Ferguson et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Expression of tutl protein is detected throughout the embryonic/larval nervous system.
(Zhou et al., 2012)
tutl is detected in da neurons with the highest levels in class III and class IV da neurons, moderate levels in class II and low levels in class I da neurons. Localization is also seen in da neuron dendrites and axons.
(Sulkowski et al., 2011)
tutl is detected in cell bodies and along the dendrites of class I neurons ddaD and ddaE in third instar larvae. It is also observed in the cell body of class IV neuron ddaC, in the class I neuron ddaB, and in the class III neurons ddaA and ddaF. It is also expressed in other sensory neurons in the cluster.
(Long et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}tutlGAL4
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of embryonic/larval central nervous system
(Zhou et al., 2012)
class III dendritic arborizing neuron

Comment: not expressed in ddaF neurons

(Tsubouchi et al., 2012, Zhou et al., 2012)
Reporter: P{GMR91F06-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of central nervous system
(Zhou et al., 2012)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tutl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tutl
Transgenic constructs containing regulatory region of tutl
Deletions and Duplications ( 29 )
Disrupted in
Df(2L)dp-h28
(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)ed-dp
(Al-Anzi and Wyman, 2009, Bodily et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)Exel8011
(Ryder, 2004.4.26)
Df(2L)M24F11
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)M24F-B
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-1
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-11
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)tutl-bdl
(Cameron et al., 2013)
Df(2L)tutl
(Zhou et al., 2012)
Not disrupted in
Df(2L)dp-cl-h3
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)dp-h19
(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)dp-h24
(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)dp-h25
(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)ed1
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)ED250
(Mathew et al., 2009)
Df(2L)ED251
(Mathew et al., 2009)
Df(2L)ED252
(Mathew et al., 2009)
Df(2L)ED3006-2L
(Mathew et al., 2009)
Df(2L)Exel6010
(Mathew et al., 2009)
Df(2L)Exel9062
(Mathew et al., 2009)
Df(2L)sc19-3
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-4
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-5
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-6
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-8
(BDGP Project Members, 1994-1999)
Df(2L)sc19-10
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-12
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)sc19-13
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Df(2L)tkv3
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2L)BSC295)
lethal | recessive
lethal - all die before end of embryonic stage
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die
partially lethal - majority live
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
behavior defective | adult stage | recessive
behavior defective | larval stage (with Df(2L)ed-dp)
behavior defective | larval stage (with Df(2L)tutl4)
behavior defective | larval stage | recessive
flightless | recessive
locomotor behavior defective | larval stage | recessive
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4elav-C155
neuroanatomy defective, with Scer\GAL4G14
neuroanatomy defective, with Scer\GAL4GMR.PF
neuroanatomy defective, with Scer\GAL4how-24B
neuroanatomy defective, with Scer\GAL4ppk.1.9
neuroanatomy defective, with Scer\GAL4sca-109-68
neuroanatomy defective, with Scer\GAL4sim.PS
neuroanatomy defective, with Scer\GAL4tutl-GAL4
neuroanatomy defective (with Df(2L)ed-dp)
neuroanatomy defective (with tutl23)
neuroanatomy defective (with tutl01085)
neuroanatomy defective (with tutlex383)
neuroanatomy defective (with tutlk14703)
neuroanatomy defective | somatic clone
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during embryonic stage
some die during pupal stage
some die during pupal stage, with Scer\GAL4pnr-MD237
touch response defective | third instar larval stage
touch response defective | third instar larval stage (with Df(2L)tutl)
touch response defective | third instar larval stage (with tutl23)
touch response defective | third instar larval stage (with tutl01085)
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult optic lobe, with Scer\GAL4GMR.PF
axon
chaeta | supernumerary, with Scer\GAL4pnr-MD237
commissure
commissure, with Scer\GAL4elav-C155
commissure, with Scer\GAL4sim.PS
commissure (with Df(2L)ed-dp)
dendrite & dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
dendrite & dorsal multidendritic neuron ddaC (with tutl23)
dendrite & dorsal multidendritic neuron ddaC (with tutl01085)
dendrite & dorsal multidendritic neuron ddaC | somatic clone
dendrite & dorsal multidendritic neuron ddaE
dendrite & dorsal multidendritic neuron ddaE (with Df(2L)ed-dp)
dendrite & dorsal multidendritic neuron ddaE (with tutl23)
dendrite & dorsal multidendritic neuron ddaE (with tutl01085)
dendrite & dorsal multidendritic neuron ddaE | somatic clone
intermediate longitudinal fascicle
intermediate longitudinal fascicle (with tutl01085)
intermediate longitudinal fascicle (with tutlex383)
intersegmental nerve branch ISNb of A1-7
intersegmental nerve branch ISNd of A1-7
intersegmental nerve branch ISNd of A1-7, with Scer\GAL4elav-C155
intersegmental nerve branch ISNd of A1-7, with Scer\GAL4G14
intersegmental nerve branch ISNd of A1-7, with Scer\GAL4how-24B
intersegmental nerve branch ISNd of A1-7, with Scer\GAL4sca-109-68
intersegmental nerve branch ISNd of A1-7, with Scer\GAL4sim.PS
lateral longitudinal fascicle
lateral longitudinal fascicle (with tutl01085)
lateral longitudinal fascicle (with tutlex383)
lateral medial fascicle
lateral medial fascicle (with tutl01085)
lateral medial fascicle (with tutlex383)
longitudinal connective
longitudinal connective, with Scer\GAL4elav-C155
longitudinal connective, with Scer\GAL4sim.PS
longitudinal connective (with Df(2L)ed-dp)
medial longitudinal fascicle
medial longitudinal fascicle (with tutl01085)
medial longitudinal fascicle (with tutlex383)
mesothoracic tergum, with Scer\GAL4pnr-MD237
midline crossing tract
midline crossing tract (with tutl01085)
midline crossing tract (with tutlex383)
neuropil, with Scer\GAL4elav-C155
optic chiasma
photoreceptor cell R7, with Scer\GAL4tutl-GAL4
photoreceptor cell R7 (with tutl23)
photoreceptor cell R7 (with tutlk14703)
photoreceptor cell R7 | somatic clone
photoreceptor cell R8 | somatic clone
rhabdomere R7
transverse nerve, with Scer\GAL4elav-C155
transverse nerve, with Scer\GAL4G14
transverse nerve, with Scer\GAL4how-24B
transverse nerve, with Scer\GAL4sca-109-68
transverse nerve, with Scer\GAL4sim.PS
ventral nerve cord commissure
ventral nerve cord commissure (with tutl01085)
ventral nerve cord commissure (with tutlex383)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\IGSF9B
9 of 15
Yes
Yes
Hsap\IGSF9
9 of 15
Yes
Yes
 
Hsap\KIRREL1
1 of 15
No
No
Hsap\KIRREL2
1 of 15
No
No
Hsap\KIRREL3
1 of 15
No
No
Hsap\LRIT1
1 of 15
No
No
Hsap\LRIT3
1 of 15
No
No
Hsap\MDGA1
1 of 15
No
No
Hsap\MDGA2
1 of 15
No
No
Hsap\MFAP3
1 of 15
No
Yes
Hsap\MYPN
1 of 15
No
No
Hsap\PALLD
1 of 15
No
No
Hsap\PAPLN
1 of 15
No
No
Hsap\SDK1
1 of 15
No
No
Hsap\USH2A
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Igsf9
9 of 15
Yes
Yes
Mmus\Igsf9b
8 of 15
No
Yes
Mmus\Kirrel2
1 of 15
No
No
 
Mmus\Kirrel3
1 of 15
No
No
 
Mmus\Kirrel
1 of 15
No
No
 
Mmus\Lrit1
1 of 15
No
No
Mmus\Lrit3
1 of 15
No
No
Mmus\Mdga1
1 of 15
No
No
Mmus\Mdga2
1 of 15
No
No
Mmus\Myot
1 of 15
No
Yes
Mmus\Mypn
1 of 15
No
No
Mmus\Nrcam
1 of 15
No
No
Mmus\Papln
1 of 15
No
No
Mmus\Ptprq
1 of 15
No
Yes
Mmus\Sdk1
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\Igsf9b
9 of 13
Yes
Yes
Rnor\Igsf9
8 of 13
No
Yes
Rnor\Kirrel1
1 of 13
No
No
Rnor\Kirrel2
1 of 13
No
No
Rnor\Kirrel3
1 of 13
No
No
Rnor\LOC100360205
1 of 13
No
Yes
Rnor\Lrit1
1 of 13
No
No
Rnor\Mdga1
1 of 13
No
No
Rnor\Mdga2
1 of 13
No
No
Rnor\Mfap3
1 of 13
No
Yes
Rnor\Myot
1 of 13
No
Yes
Rnor\Nrcam
1 of 13
No
No
 
Rnor\Opcml
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\igsf9b
5 of 12
Yes
Yes
Xtro\igsf9
4 of 12
No
No
Xtro\kirrel2
1 of 12
No
No
Xtro\lrit3
1 of 12
No
Yes
Xtro\mdga2
1 of 12
No
Yes
Xtro\mfap3
1 of 12
No
Yes
Xtro\papln
1 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\igsf9bb
10 of 15
Yes
Yes
Drer\igsf9a
9 of 15
No
Yes
Drer\igsf9ba
7 of 15
No
Yes
Drer\igsf9b
6 of 15
No
Yes
Drer\dscama
1 of 15
No
No
Drer\dscamb
1 of 15
No
No
Drer\itgb4
1 of 15
No
No
Drer\kirrel1a
1 of 15
No
No
Drer\kirrel1b
1 of 15
No
No
Drer\kirrel3a
1 of 15
No
No
Drer\kirrel3b
1 of 15
No
No
Drer\kirrel3l
1 of 15
No
No
Drer\lrit1a
1 of 15
No
No
Drer\lrit1b
1 of 15
No
No
Drer\lrit3a
1 of 15
No
No
Drer\lrit3b
1 of 15
No
No
Drer\mybpha
1 of 15
No
No
Drer\mybphb
1 of 15
No
No
Drer\ncam1b
1 of 15
No
No
Drer\paplna
1 of 15
No
No
Drer\sdk1a
1 of 15
No
No
Drer\sdk1b
1 of 15
No
No
Drer\si:ch1073-459j12.1
1 of 15
No
No
Drer\si:dkeyp-97a10.3
1 of 15
No
Yes
Drer\ush2a
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\igcm-2
6 of 15
Yes
Yes
Cele\C53A5.13
1 of 15
No
Yes
Cele\ncam-1
1 of 15
No
No
Cele\rig-3
1 of 15
No
Yes
Cele\T04C9.3
1 of 15
No
Yes
Cele\zig-1
1 of 15
No
Yes
Cele\zig-2
1 of 15
No
No
Cele\zig-3
1 of 15
No
No
Cele\zig-4
1 of 15
No
No
Cele\zig-6
1 of 15
No
Yes
Cele\zig-7
1 of 15
No
Yes
Cele\zig-11
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900MQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\tutl
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000103
Drosophila simulans
Dsim\GD23274
Drosophila sechellia
Dsec\GM18461
Drosophila erecta
Dere\GG24990
Drosophila yakuba
Dyak\GE18278
Drosophila ananassae
Dana\GF15018
Drosophila pseudoobscura pseudoobscura
Dpse\GA13718
Drosophila persimilis
Dper\GL14010
Drosophila willistoni
Dwil\GK24611
Drosophila virilis
Dvir\GJ16222
Drosophila mojavensis
Dmoj\GI13998
Drosophila grimshawi
Dgri\GH10066
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022412
Glossina morsitans
Tsetse fly
Gmor\GMOY001681
Mayetiola destructor
Hessian fly
Mdes\Mdes005074
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006522
Anopheles darlingi
American malaria mosquito
Adar\ADAC006214
Anopheles gambiae
Malaria mosquito
Agam\AGAP007928
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002412
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0164 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010354
Danaus plexippus
Monarch butterfly
Dple\DPOGS208540-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008751
Apis florea
Little honeybee
Aflo\2213828628
Apis mellifera
Western honey bee
Amel\GB53012
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10510
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10511
Bombus terrestris
Buff-tailed bumblebee
Bter\15204856
Linepithema humile
Argentine ant
Lhum\LH17792
Linepithema humile
Argentine ant
Lhum\LH17790
Linepithema humile
Argentine ant
Lhum\LH17791
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0021b2
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011343
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02237
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08291
Pediculus humanus
Human body louse
Phum\PHUM322860
Rhodnius prolixus
Kissing bug
Rpro\RPRC002888
Cimex lectularius
Bed bug
Clec\CLEC006108
Cimex lectularius
Bed bug
Clec\CLEC006107
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068599
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08324
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X043P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010812
Ixodes scapularis
Black-legged tick
Isca\ISCW020695
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82622.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67280.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65985.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g05950
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02TX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3f_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3/Ig_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004965
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001450
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000022603
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (32)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bdl
3 of 10
Dscam2
2 of 10
Ama
1 of 10
babos
1 of 10
Bsg
1 of 10
CG13506
1 of 10
CG44153
1 of 10
Cont
1 of 10
DIP-δ
1 of 10
DIP-ε
1 of 10
DIP-η
1 of 10
DIP-ι
1 of 10
DIP-θ
1 of 10
DIP-ζ
1 of 10
dpr2
1 of 10
dpr3
1 of 10
dpr5
1 of 10
dpr10
1 of 10
dpr11
1 of 10
dpr15
1 of 10
dpr17
1 of 10
dpr19
1 of 10
dpr21
1 of 10
Dscam1
1 of 10
Dscam3
1 of 10
Dscam4
1 of 10
Fas2
1 of 10
ImpL2
1 of 10
kirre
1 of 10
otk2
1 of 10
rst
1 of 10
Strn-Mlck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IGSF9B; immunoglobulin superfamily member 9B
    9 of 15
    613773
        IGSF9; immunoglobulin superfamily member 9
        9 of 15
        609738
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            tutl
            bead aggregation assay, fluorescence microscopy, inferred by author
            (Ferguson et al., 2009)
            tutl - bdl
            anti tag coimmunoprecipitation, anti tag western blot
            (Cameron et al., 2013)
            tutl - ed
            enzyme linked immunosorbent assay
            (Ozkan et al., 2013)
            RNA-RNA
            Physical Interaction
            Assay
            References
            tutl - mir-1
            luminiscence technology
            (Robins et al., 2005)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            tutl
            suppressible
            bdl
            (Cameron et al., 2013)
            tutl
            enhanceable
            Kap-α3
            (Ferguson et al., 2009)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Actβ
            enhanceable
            tutl
            (Ferguson et al., 2009)
            fra
            enhanceable
            tutl
            (Al-Anzi and Wyman, 2009)
            H
            suppressible
            tutl
            (Müller et al., 2005)
            Kap-α3
            enhanceable
            tutl
            (Ferguson et al., 2009)
            mbl
            enhanceable
            tutl
            (Vicente-Crespo et al., 2008)
            mbl
            suppressible
            tutl
            (Vicente-Crespo et al., 2008)
            peb
            suppressible
            tutl
            (Wilk et al., 2004)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with bdl.
            (UniProt, Q967D7 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-12
            Cytogenetic map
            24E1-24E1
            Sequence location
            2L:4,283,148..4,323,781 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            24E1-24E1
            Limits computationally determined from genome sequence between P{lacW}edk01102 and P{PZ}tutl01085
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            24E1-24E2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            24E1-24E2
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location
            2-12
            (FlyBase, 2016)
            2-12.8
            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (21)
            Genomic Clones (47)
            cDNA Clones (83)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            polyclonal
            (Zhou et al., 2012, Sulkowski et al., 2011, Ferguson et al., 2009, Long et al., 2009)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for identity of: tutl l(2)01085 CG15427 CG15428
            (Broadie, 2001.5.8)
            Source for identity of: tutl l(2)01085 CG15426 CG15427
            (FlyBase, 1996-)
            Source for database merge of
            Source for merge of: l(2)01085 CG15426
            (Misra, 2000.8.25)
            Source for merge of: tutl l(2)01085 CG15427
            (Bodily et al., 2001)
            Source for merge of: tutl l(2)24Df
            (Dean, 2003.6.5)
            Additional comments
            Source for identity of tutl l(2)01085 CG15426 CG15427 was sequence comparison ( date:010521 ).
            (FlyBase, 1996-)
            Other Comments
            A small subset of tutl-positive neurons are required for modulating directional change in response to gentle touch in larvae.
            (Zhou et al., 2012)
            tutl promotes midline attraction via a netrin-independent mechanism, ad not as part of the netrin signaling pathway.
            (Al-Anzi and Wyman, 2009)
            tutl promotes both motor and retinal axon branching and invasive behavior.
            (Al-Anzi and Wyman, 2009)
            tutl has a cell-autonomous role in specifying R7 axonal tiling (in parallel with Actβ).
            (Ferguson et al., 2009)
            tutl restricts dendrite branching in neurons with simple arbors and promotes self-avoidance in neurons with highly complex arbors.
            (Long et al., 2009)
            Mutations in tutl result in an abnormal response to tactile stimulation, the inability to regain an upright position from an inverted position, and the inability to fly in adulthood.
            (Bodily et al., 2001)
            Origin and Etymology
            Discoverer
            Etymology
            The gene is named "turtle" after the mutant phenotype; mutants are unable to regain an upright position from an inverted position.
            (Bodily et al., 2001)
            Identification
            External Crossreferences and Linkouts ( 85 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            ApoDroso - Functional genomic database for photoreceptor development, survival and function
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (15)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (93)