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Gene Dmel\tutl

General Information
Symbol	Dmel\tutl	Species	D. melanogaster
Name	turtle	Annotation symbol	CG15427
Feature type	protein_coding_gene	FlyBase ID	FBgn0010473
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	jf4, l(2)01085
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24E1-24E1	Sequence location	2L:4,283,148..4,323,781 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene turtle is referred to in FlyBase by the symbol Dmel\tutl (CG15427, FBgn0010473). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: synaptic target recognition; regulation of dendrite morphogenesis; dendrite self-avoidance; larval behavior; axon guidance; axonal defasciculation; lateral inhibition; adult locomotory behavior; flight behavior; axon midline choice point recognition. 35 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; peripheral nervous system; multicellular structure; external compound sense organ; intersegmental nerve branch ISNd of A1-7; adult; longitudinal connective; larval abdominal segment. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin V-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Gene sequence location is 2L:4283148..4323781.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms embryonic/larval brain eye disc embryonic/larval optic lobe third instar larval stage embryonic/larval central nervous system embryonic/larval salivary gland morphogenetic furrow embryonic/larval glial cell embryonic stage 17 optic nerve embryonic/larval digestive system
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24E1-24E1   Limits computationally determined from genome sequence between P{lacW}edk01102 and P{PZ}tutl01085
Experimentally Determined Cytological Location
Cytogenetic map Notes References 24E1-24E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 24E1-24E2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tutl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tutl-RA FBtr0089268  NM_164578   1886   377 tutl-RC FBtr0089269  NM_164577   4595   903 tutl-RD FBtr0089270  NM_164576   5179   1508 tutl-RE FBtr0089271  NM_080127   3388   902 tutl-RF FBtr0301863  NM_001169397   5250   963 tutl-RG FBtr0301864  NM_001169398   5127   1508 tutl-RH FBtr0333484  NM_001273090   7436   1533 tutl-RI FBtr0333485  NM_001273091   7798   963
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tutl-PA   FBpp0088325   41.9   377   8.04     NP_722969   AAF51031 tutl-PC   FBpp0088326   100.4   903   8.12     NP_722968   AAF51030 tutl-PD   FBpp0088327   168.2   1508   9.05     NP_722967   AAF51029 tutl-PE   FBpp0088328   100.5   902   8.12     NP_524866   AAN11173 tutl-PF   FBpp0291077   107.4   963   8.16     NP_001162868   ACZ94159 tutl-PG   FBpp0291078   168.2   1508   9.05     NP_001162869   ACZ94160 tutl-PH   FBpp0305668   171.1   1533   9.21     NP_001260019   AGB92555 tutl-PI   FBpp0305669   107.4   963   8.16     NP_001260020   AGB92556
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567639   AA821030   AA949358   AE014134 AAF51029   AE014134 AAF51030   AE014134 AAF51031   AE014134 AAN11173   AE014134 ACZ94159   AE014134 ACZ94160   AE014134 AGB92555   AE014134 AGB92556   AI108839   AI261081   AI292768   AI386576   AJ312132 CAC39161   AJ312133 CAC39162   AJ312134 CAC39163   AJ312135 CAC39164   AY118601   BF494314   BG638519   BI173429   BI352710   BI629445   BI631398   BP545347   BP545348   BP547902   BP558384   BP558385   BT010247   BT071805   CO273102   CO276496   CO276527   CO277890   CO280996   CO282215   CO293845   CO304288   CO313600   CO314659   CO316684   CO317768   CO320602   CO321428   CO328742   CO329536   CO330154   CO330278   CO331727   CO339170   CO339493   CZ466150   CZ471022   CZ485649   CZ485650   DN153993   EC057378   EC062618   EC064962   EC065283   EC067311   EC071911   EC072964   EC074410   EC079804   EC085005   EC085649   EC090209   EC090550   EC197687   EC198595   EC210624   EC213352   EC215502   EC216087   EC222411   EC224346   EC225880   EC225891   EC227881   EC232181   EC238546   EC239444   EC245378   EC248498   EC256682   EC258750   EC259046   G00578   GH941457   GH941716   GH941785   GH942977   GH943575   GH946284   GH947105   GH949678   GH951187   GH951346   GH953503   GH954182   GH956103   GH956273   GH957828   GH957912   GH958171   GH958491   GH960156   GH961401   GH961940   GH962606   GH962893   GH964069   GH964205   GH964975   GH966513   GH970267   GH970712   GH971525   GH971798   GH971945   GH972364   GH973248   GH973430   GH974655   GH976701   GH977099   GH977775   GH978784   GH979443   GH980512
UniProtKB/Swiss-Prot	Q967D7
UniProtKB/TrEMBL	E1JHS9 E1JHT0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | gap expression pattern   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   dorsal ectoderm   (Fisher et al., 2012) organism | gap expression pattern   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 14   embryonic/larval salivary gland   (Al-Anzi and Wyman, 2009) embryonic/larval digestive system   (Al-Anzi and Wyman, 2009) embryonic/larval glial cell   (Al-Anzi and Wyman, 2009) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic optic lobe   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) third instar larval stage   morphogenetic furrow   (Al-Anzi and Wyman, 2009) eye disc | restricted   (Al-Anzi and Wyman, 2009) Comment:isoform-specific expression embryonic/larval brain   (Al-Anzi and Wyman, 2009) embryonic/larval optic lobe   (Al-Anzi and Wyman, 2009) optic lobe & optic nerve   (Al-Anzi and Wyman, 2009) Comment:isoform-specific expression RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 13   ventral midline   (Al-Anzi and Wyman, 2009) embryonic stage 14 -- 17   embryonic/larval central nervous system   (Al-Anzi and Wyman, 2009)
Additional Descriptive Data
	tutl expression is observed in the embryonic central nervous system, salivary glands and gut as well as in larval eye disc and brain. Isoform-specific levels and expression patterns are described. (Al-Anzi and Wyman, 2009)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference pharate adult stage P8   lobula | restricted   (Ferguson et al., 2009) lamina | restricted   (Ferguson et al., 2009) optic lobe | restricted   (Ferguson et al., 2009) pharate adult stage P9   lobula | restricted   (Ferguson et al., 2009) lobula plate | restricted   (Ferguson et al., 2009) lamina | restricted   (Ferguson et al., 2009) optic lobe | restricted   (Ferguson et al., 2009) adult stage   lobula | restricted   (Ferguson et al., 2009) lobula plate | restricted   (Ferguson et al., 2009) lamina | restricted   (Ferguson et al., 2009) optic lobe | restricted   (Ferguson et al., 2009)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    64 central nervous system, pupae P8    196 head, virgin 1-day female    62 head, virgin 4-day female    58 head, virgin 20-day female    27 head, mated 1-day female    59 head, mated 4-day female    55 head, mated 20-day female    29 head, mated 1-day male    89 head, mated 4-day male    119 head, mated 20-day male    90 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    41 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3  (64) central nervous system, pupae P8  (196) head, virgin 1-day female  (62) head, virgin 4-day female  (58) head, virgin 20-day female  (27) head, mated 1-day female  (59) head, mated 4-day female  (55) head, mated 20-day female  (29) head, mated 1-day male  (89) head, mated 4-day male  (119) head, mated 20-day male  (90) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8  (41) carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    64 central nervous system, pupae P8  (196) head, virgin 1-day female    62 head, virgin 4-day female    58 head, virgin 20-day female    27 head, mated 1-day female    59 head, mated 4-day female    55 head, mated 20-day female    29 head, mated 1-day male    89 head, mated 4-day male  (119) head, mated 20-day male    90 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    41 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    64 central nervous system, pupae P8    196 head, virgin 1-day female    62 head, virgin 4-day female    58 head, virgin 20-day female    27 head, mated 1-day female    59 head, mated 4-day female    55 head, mated 20-day female    29 head, mated 1-day male    89 head, mated 4-day male    119 head, mated 20-day male    90 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    41 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    64 central nervous system, pupae P8    196 head, virgin 1-day female    62 head, virgin 4-day female    58 head, virgin 20-day female    27 head, mated 1-day female    59 head, mated 4-day female    55 head, mated 20-day female    29 head, mated 1-day male    89 head, mated 4-day male    119 head, mated 20-day male    90 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    41 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3  (64) central nervous system, pupae P8  (196) head, virgin 1-day female  (62) head, virgin 4-day female  (58) head, virgin 20-day female  27 head, mated 1-day female  (59) head, mated 4-day female  (55) head, mated 20-day female  29 head, mated 1-day male  (89) head, mated 4-day male  (119) head, mated 20-day male  (90) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8  (41) carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    64 central nervous system, pupae P8  (196) head, virgin 1-day female    62 head, virgin 4-day female    58 head, virgin 20-day female    27 head, mated 1-day female    59 head, mated 4-day female    55 head, mated 20-day female    29 head, mated 1-day male    89 head, mated 4-day male  119 head, mated 20-day male    90 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    41 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    64 central nervous system, pupae P8    196 head, virgin 1-day female    62 head, virgin 4-day female    58 head, virgin 20-day female    27 head, mated 1-day female    59 head, mated 4-day female    55 head, mated 20-day female    29 head, mated 1-day male    89 head, mated 4-day male    119 head, mated 20-day male    90 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    41 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr    30 embryo 18-20hr    32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr  (30) embryo 18-20hr  (32) embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr    30 embryo 18-20hr    32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr    30 embryo 18-20hr    32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr    30 embryo 18-20hr    32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr  30 embryo 18-20hr  32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr    30 embryo 18-20hr    32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    11 embryo 06-08hr    17 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    21 embryo 14-16hr    25 embryo 16-18hr    30 embryo 18-20hr    32 embryo 20-22hr    20 embryo 22-24hr    21 larva L1    20 larva L2    7 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    2 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • RE40452 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010473 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15427-RD;CG15427-RE;CG15427-RC;CG15427-RA;CG15427-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for tutl Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal tutljf4 tutlMI00290 lethal | embryonic stage tutlex383 lethal | pupal stage, with Scer\GAL4pnr-MD237 tutlGD14357 lethal | recessive tutl3 tutl4 tutl01085 tutlk14703 partially lethal - majority die | pupal stage tutlk14703 partially lethal - majority live tutl1 tutl2 tutlk14703 viable, with Scer\GAL4pnr-MD237 tutlGD2558 Other Phenotypes Allele behavior defective | adult stage | recessive tutl1 tutl2 tutlk14703 behavior defective | larval stage (with Df(2L)ed-dp) tutl3 tutl4 behavior defective | larval stage (with Df(2L)tutl4) tutl3 tutl01085 behavior defective | larval stage | recessive tutl1 tutl2 tutl3 tutl4 tutl01085 tutlk14703 flightless | recessive tutl1 tutl2 tutlk14703 locomotor behavior defective | larval stage | recessive tutl4 tutlunspecified neuroanatomy defective tutl23 tutl01085 tutlex383 tutlk14703 neuroanatomy defective, with Scer\GAL4elav-C155 tutlAT02763.Scer\UAS tutlGH15753.Scer\UAS neuroanatomy defective, with Scer\GAL4G14 tutlAT02763.Scer\UAS tutlGH08133.Scer\UAS tutlGH15753.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS neuroanatomy defective, with Scer\GAL4GMR.PF tutlAT02763.Scer\UAS tutlGH08133.Scer\UAS tutlGH15753.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS neuroanatomy defective, with Scer\GAL4how-24B tutlAT02763.Scer\UAS tutlGH08133.Scer\UAS tutlGH15753.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS neuroanatomy defective, with Scer\GAL4ppk.1.9 tutlScer\UAS.cLa neuroanatomy defective, with Scer\GAL4sca-109-68 tutlAT02763.Scer\UAS tutlGH08133.Scer\UAS tutlGH15753.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS neuroanatomy defective, with Scer\GAL4sim.PS tutlAT02763.Scer\UAS tutlGH15753.Scer\UAS neuroanatomy defective, with Scer\GAL4tutl-GAL4 tutldsRNA.400.Scer\UAS neuroanatomy defective (with Df(2L)ed-dp) tutl23 tutl01085 tutlex383 neuroanatomy defective (with tutl23) tutl01085 tutlk14703 neuroanatomy defective (with tutl01085) tutl23 tutlex383 neuroanatomy defective (with tutlex383) tutl01085 neuroanatomy defective (with tutlk14703) tutl23 neuroanatomy defective | somatic clone tutl23 tutl01085 visible, with Scer\GAL4pnr-MD237 tutlGD14357 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 tutlGD14357 commissure tutlex383 commissure, with Scer\GAL4elav-C155 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS commissure, with Scer\GAL4sim.PS tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS commissure (with Df(2L)ed-dp) tutlex383 dendrite & dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9 tutlScer\UAS.cLa dendrite & dorsal multidendritic neuron ddaC (with tutl23) tutl01085 dendrite & dorsal multidendritic neuron ddaC (with tutl01085) tutl23 dendrite & dorsal multidendritic neuron ddaC | somatic clone tutl23 dendrite & dorsal multidendritic neuron ddaE tutl23 dendrite & dorsal multidendritic neuron ddaE (with Df(2L)ed-dp) tutl01085 tutl23 dendrite & dorsal multidendritic neuron ddaE (with tutl23) tutl01085 dendrite & dorsal multidendritic neuron ddaE (with tutl01085) tutl23 dendrite & dorsal multidendritic neuron ddaE | somatic clone tutl23 intermediate longitudinal fascicle tutl01085 intermediate longitudinal fascicle (with tutl01085) tutlex383 intermediate longitudinal fascicle (with tutlex383) tutl01085 intersegmental nerve branch ISNb of A1-7 tutl01085 tutlk14703 tutlex383 intersegmental nerve branch ISNd of A1-7 tutl01085 tutlk14703 tutlex383 intersegmental nerve branch ISNd of A1-7, with Scer\GAL4elav-C155 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS intersegmental nerve branch ISNd of A1-7, with Scer\GAL4G14 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS intersegmental nerve branch ISNd of A1-7, with Scer\GAL4how-24B tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS intersegmental nerve branch ISNd of A1-7, with Scer\GAL4sca-109-68 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS intersegmental nerve branch ISNd of A1-7, with Scer\GAL4sim.PS tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS lateral longitudinal fascicle tutl01085 lateral longitudinal fascicle (with tutl01085) tutlex383 lateral longitudinal fascicle (with tutlex383) tutl01085 lateral medial fascicle tutl01085 lateral medial fascicle (with tutl01085) tutlex383 lateral medial fascicle (with tutlex383) tutl01085 longitudinal connective tutlex383 longitudinal connective, with Scer\GAL4elav-C155 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS longitudinal connective, with Scer\GAL4sim.PS tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS longitudinal connective (with Df(2L)ed-dp) tutlex383 medial longitudinal fascicle tutl01085 medial longitudinal fascicle (with tutl01085) tutlex383 medial longitudinal fascicle (with tutlex383) tutl01085 mesothoracic tergum, with Scer\GAL4pnr-MD237 tutlGD14357 midline crossing tract tutl01085 midline crossing tract (with tutl01085) tutlex383 midline crossing tract (with tutlex383) tutl01085 neuropil, with Scer\GAL4elav-C155 tutlAT02763.Scer\UAS optic chiasm tutlk14703 optic lobe, with Scer\GAL4GMR.PF tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS photoreceptor cell R7, with Scer\GAL4tutl-GAL4 tutldsRNA.400.Scer\UAS photoreceptor cell R7 (with tutl23) tutlk14703 photoreceptor cell R7 (with tutlk14703) tutl23 photoreceptor cell R7 | somatic clone tutl01085 photoreceptor cell R8 | somatic clone tutl01085 transverse nerve, with Scer\GAL4elav-C155 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS transverse nerve, with Scer\GAL4G14 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS transverse nerve, with Scer\GAL4how-24B tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS transverse nerve, with Scer\GAL4sca-109-68 tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS tutlHL01565.Scer\UAS tutlLD28224.Scer\UAS tutlGH08133.Scer\UAS transverse nerve, with Scer\GAL4sim.PS tutlGH15753.Scer\UAS tutlAT02763.Scer\UAS ventral nerve cord commissure tutl01085 ventral nerve cord commissure (with tutl01085) tutlex383 ventral nerve cord commissure (with tutlex383) tutl01085
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of tutl Class Mutagen Stocks Known lesion tutlk14703 hypomorphic allele - genetic evidence P-element activity 2 Yes tutl01085 hypomorphic allele - genetic evidence P-element activity 1 Yes tutlc00018 piggyBac transposase 1 -- tutlc06836 piggyBac transposase 1 -- tutlf02770 1 -- tutlf03096 piggyBac transposase 1 -- tutlGS13843 1 -- tutlMI00290-DV.1 site specific recombinase 1 Yes tutlMI00290-GFSTF.1 site specific recombinase 1 Yes tutlMI00290-mCh.1 site specific recombinase 1 Yes tutlMI00290 1 Yes tutl23 amorphic allele - genetic evidence FLPase 0 Yes tutl1 hypomorphic allele - genetic evidence Delta2-3 0 Yes tutl2 hypomorphic allele - genetic evidence Delta2-3 0 Yes tutl3 hypomorphic allele - genetic evidence Delta2-3 0 Yes tutl4 loss of function allele Delta2-3 0 Yes tutlex383 P-element activity 0 Yes tutlGAL4 recombination P-element activity 0 Yes tutljf4 0 -- tutlMI00290-BM.1 site specific recombinase 0 Yes tutlMI00290-HS.1 site specific recombinase 0 Yes tutlMI00290-KV.1 site specific recombinase 0 Yes tutlunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tutl Class Mutagen Stocks Known lesion tutlGD14357 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes tutlGD2558 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tutlKK108880 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tutlAT02763.Scer\UAS in vitro construct - regulatory fusion 0 Yes tutldsRNA.400.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes tutlGH08133.Scer\UAS in vitro construct - regulatory fusion 0 Yes tutlGH15753.Scer\UAS in vitro construct - regulatory fusion 0 Yes tutlHL01565.Scer\UAS in vitro construct - regulatory fusion 0 Yes tutlLD28224.Scer\UAS in vitro construct - regulatory fusion 0 Yes tutlScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes tutlScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes tutlΔcyto.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)dp-h28 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) Df(2L)ed-dp (Spradling et al., 1999, Bodily et al., 2001, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999, Al-Anzi and Wyman, 2009) Df(2L)Exel8011 (Ryder, 2004.4.26) Df(2L)M24F11 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)M24F-B (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-11 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Not disrupted in	Df(2L)dp-cl-h3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)dp-h19 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) Df(2L)dp-h24 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) Df(2L)dp-h25 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) Df(2L)ed1 (Spradling et al., 1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999) Df(2L)ED250 (Mathew et al., 2009) Df(2L)ED251 (Mathew et al., 2009) Df(2L)ED252 (Mathew et al., 2009) Df(2L)ED3006-2L (Mathew et al., 2009) Df(2L)Exel6010 (Mathew et al., 2009) Df(2L)Exel9062 (Mathew et al., 2009) Df(2L)sc19-3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-4 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-5 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-6 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-8 (BDGP Project Members, 1994-1999) Df(2L)sc19-10 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-12 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-13 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)tkv3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2558} NA P{GD14357} NA P{KK108880} NA P{UAS-tutl.AT02763} NA P{UAS-tutl.dsRNA} NA P{UAS-tutl.F} NA P{UAS-tutl.GH08133} NA P{UAS-tutl.GH15753} NA P{UAS-tutl.HL01565} NA P{UAS-tutl.L} NA P{UAS-tutl.LD28224} NA P{UAS-tutl.Δcyto} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}tutlk14703 No P{PZ}tutl01085 No miscellaneous insertions Mi{MIC}tutlMI00290 NA Mi{PT-BM.1}tutlMI00290-BM.1 NA Mi{PT-DV.1}tutlMI00290-DV.1 NA Mi{PT-GFSTF.1}tutlMI00290-GFSTF.1 NA Mi{PT-HS.1}tutlMI00290-HS.1 NA Mi{PT-KV.1}tutlMI00290-KV.1 NA Mi{PT-mCh.1}tutlMI00290-mCh.1 NA PBac{PB}tutlc00018 NA PBac{PB}tutlc06836 NA PBac{WH}tutlf02770 NA PBac{WH}tutlf03096 NA insertion of mobile activating element P{GSV6}tutlGS13843 NA PBac{WHr}tutl23 NA insertion of enhancer trap binary system P{GawB}tutlGAL4 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data on: 2007-10-12)
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult locomotory behavior inferred from mutant phenotype (Bodily et al., 2001) axonal defasciculation inferred from mutant phenotype (Al-Anzi and Wyman, 2009) axon guidance inferred from mutant phenotype (Al-Anzi and Wyman, 2009) axon midline choice point recognition inferred from mutant phenotype (Al-Anzi and Wyman, 2009) dendrite self-avoidance inferred from mutant phenotype (Long et al., 2009) flight behavior inferred from mutant phenotype (Bodily et al., 2001) larval behavior inferred from mutant phenotype (Bodily et al., 2001) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) regulation of dendrite morphogenesis inferred from mutant phenotype (Long et al., 2009) synaptic target recognition inferred from mutant phenotype (Kurusu et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
peripheral nervous system development non-traceable author statement (Cox et al., 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tutl allele Gene References tutlk14703 peb (Wilk et al., 2004) unspecified H (Mueller et al., 2005) p53 (Mueller et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0010473 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46015
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JM880 Dipteran inclusive ortholog search EOG6Z8Z4C Insect inclusive ortholog search EOG6WSV5C Arthropod inclusive ortholog search EOG6M0CH1 Metazoa inclusive ortholog search EOG63VBN6
Orthologs in Drosophila Species (EOG6JM880)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tutl     Drosophila simulans   Dsim\GD23275     Drosophila simulans   Dsim\GD23274 Y   Drosophila sechellia   Dsec\GM18461 Y   Drosophila erecta   Dere\GG24990 Y   Drosophila yakuba   Dyak\GE18278 Y   Drosophila ananassae   Dana\GF15018 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13718 Y   Drosophila persimilis   Dper\GL14010 Y   Drosophila willistoni   Dwil\GK24611 Y   Drosophila virilis   Dvir\GJ16222 Y   Drosophila mojavensis   Dmoj\GI13998     Drosophila mojavensis   Dmoj\GI18310     Drosophila mojavensis   Dmoj\GI16507     Drosophila grimshawi   Dgri\GH10066 Y
Orthologs in non-Drosophila Dipterans (EOG6Z8Z4C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006522   Anopheles gambiae Malaria mosquito  Agam\AGAP007928   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801859
Orthologs in non-Dipteran Insects (EOG6WSV5C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53012   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011343   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16893   Atta cephalotes Leafcutter ant  Acep\ACEP11354   Atta cephalotes Leafcutter ant  Acep\ACEP11350   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13448   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22532   Linepithema humile Argentine ant  Lhum\LH17791   Linepithema humile Argentine ant  Lhum\LH17790   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19379   Solenopsis invicta Red fire ant  Sinv\SINV16870   Solenopsis invicta Red fire ant  Sinv\SINV16865   Acyrthosiphon pisum Pea aphid  Apim\ACYPI068599   Bombyx mori Silkmoth  Bmor\BGIBMGA010354   Pediculus humanus Human body louse  Phum\PHUM322860   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08291
Orthologs in non-Insect Arthropods (EOG6M0CH1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW020695
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23274 Drosophila sechellia Dsec\GM18461 Drosophila erecta Dere\GG24990 Drosophila yakuba Dyak\GE18278 Drosophila ananassae Dana\GF15018 Drosophila pseudoobscura pseudoobscura Dpse\GA13718 Drosophila persimilis Dper\GL14010 Drosophila willistoni Dwil\GK24611 Drosophila virilis Dvir\GJ16222 Drosophila grimshawi Dgri\GH10066
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	10979 P{PZ}tutl01085 cn1/CyO; ry506 30692 y1 w*; Mi{MIC}tutlMI00290/CyO 10451 y1 w67c23; P{lacW}tutlk14703/CyO
Harvard	- PBac{PB}tutlc00018 - PBac{PB}tutlc06836 - PBac{WH}tutlf02770 - PBac{WH}tutlf03096
Kyoto	204992 y1 w67c23; P{GSV6}tutlGS13843/SM1
VDRC	v108746 P{KK108880}VIE-260B v3064 w1118; P{GD2558}v3064 v27045 w1118; P{GD14357}v27045 v27046 w1118; P{GD14357}v27046
	More stocks available...
Genomic Clones ( 1 )
	BACR09F08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 85 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP03459 RE40452
Other clones	RT01550
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02763 GH08133 GH15753 GH16705 GM05445 GM20469 HL01565 LP05157 RE16344 RH58315 RH60955
Other clones	56105 190162 190718 EK109522 EK121147 EK121236 EK127425 EK149010 EK155702 EK159823 EK185647 EK204954 EK233533 EK237362 EK244255 EK265638 EK269034 EK286460 EK291312 EK293049 EK294626 EK294853 EK301517 EP01013 EP02123 FGC030G09 FGH121H07 FGM314F07 LD28224 RP004032313 RP004041429 RP004047960 RP004049293 RP004082056 RP004085456 RP004118405 RP004128638 RP004157977 RP004166058 RP004179661 RP004213279 RP004222479 RP004240636 RP004249285 RP004250724 RP004256044 RP004256511 RP004262846 RP004262910 RP004267908 RP004279527 RP004301973 RP004312314 RP004359016 RP004381632 RP004385125 RP004398970 RP004405195 RP004407356 RP004410079 RP004423548 RP004429799 RP004478488 RP004497180 RP004507622 RP004508519 RP004519957 RP004524119 RP004530385 RP004534762 RP004548426
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010473 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46015
Antibody Information
	polyclonal (Ferguson et al., 2009, Long et al., 2009, Sulkowski et al., 2011)
Other Information
Discoverer
Etymology
	The gene is named "turtle" after the mutant phenotype; mutants are unable to regain an upright position from an inverted position. (Bodily et al., 2001)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tutl l(2)01085 CG15426 CG15427 (FlyBase, 1996-) Source for identity of: tutl l(2)01085 CG15427 CG15428 (Broadie, 2001.5.8)
Source for database merge of	Source for merge of: l(2)01085 CG15426 (Misra, 2000.8.25) Source for merge of: tutl l(2)24Df (Dean, 2003.6.5) Source for merge of: tutl l(2)01085 CG15427 (Bodily et al., 2001)
Additional comments	Source for identity of tutl l(2)01085 CG15426 CG15427 was sequence comparison (date:010521). (FlyBase, 1996-)
Other Comments
	tutl promotes midline attraction via a netrin-independent mechanism, ad not as part of the netrin signaling pathway. (Al-Anzi and Wyman, 2009) tutl promotes both motor and retinal axon branching and invasive behavior. (Al-Anzi and Wyman, 2009) tutl has a cell-autonomous role in specifying R7 axonal tiling (in parallel with Actβ). (Ferguson et al., 2009) tutl restricts dendrite branching in neurons with simple arbors and promotes self-avoidance in neurons with highly complex arbors. (Long et al., 2009) Mutations in tutl result in an abnormal response to tactile stimulation, the inability to regain an upright position from an inverted position, and the inability to fly in adulthood. (Bodily et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080127 NM_164576 NM_164577 NM_164578 NM_001169397 NM_001169398 NM_001273090 NM_001273091 RefSeq (Proteins) • NP_524866 NP_722967 NP_722968 NP_722969 NP_001162868 NP_001162869 NP_001260019 NP_001260020 DDBJ / EMBL / GenBank • AA567639 AA949358 AAF51029 AAF51030 AAF51031 AAN11173 ACZ94159 ACZ94160 AGB92555 AGB92556 AI108839 AI292768 AI386576 AJ312132 AJ312133 AJ312134 AJ312135 BG638519 CAC39161 CAC39162 CAC39163 CAC39164 CZ466150 CZ471022 CZ485649 CZ485650 G00578 Entrez Gene - A searchable database of RefSeq genes. • 46015 UniProtKB/Swiss-Prot • Q967D7 UniProtKB/TrEMBL • E1JHS9 E1JHT0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE40452
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0010473 DRSC - Results from RNAi screens. • FBgn0010473 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010473 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15427-RD;CG15427-RE;CG15427-RC;CG15427-RA;CG15427-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010473 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46015 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46015 modMine - Data generated by the modENCODE project. • FBgn0010473
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG15426   CG15427 (Keleman et al., 2009.8.5) CG15428   CT35489 (Hynes and Zhao, 2000) CT35490 (Hynes and Zhao, 2000) jf4 (Dean, 2003.6.5, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Df   l(2)01085 (Misra, 2000.8.25, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(2)jf4   tutl (Jordan et al., 2006, Venken et al., 2011, Venken et al., 2011, Vicente-Crespo et al., 2008, Long et al., 2009, Al-Anzi and Wyman, 2009, Mathew et al., 2009, Ferguson et al., 2009, Hazelett et al., 2009)
Name Synonym	lethal(2)24Df   turtle (Bodily et al., 2001, Jordan et al., 2006, Kurusu et al., 2008, Vicente-Crespo et al., 2008, Carbone et al., 2009, Al-Anzi and Wyman, 2009, Mathew et al., 2009) Turtle (Kwon et al., 2008, Long et al., 2009, Ferguson et al., 2009)
Secondary FlyBase IDs
	FBgn0004699 FBgn0031593 FBgn0031594 FBgn0031595
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 2 ) FlyBase analysis  ( 4 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Letter  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Koper et al., 2012, PLoS ONE 7(4): e36339 Analysis of Adhesion Molecules and Basement Membrane Contributions to Synaptic Adhesion at the Drosophila Embryonic NMJ. [FBrf0218212] Tsubouchi et al., 2012, Curr. Biol. 22(22): 2124--2134 Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae. [FBrf0219946] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Sulkowski et al., 2011, PLoS ONE 6(7): e22611 Turtle functions downstream of cut in differentially regulating class specific dendrite morphogenesis in Drosophila. [FBrf0214622] Venken et al., 2011, Nat. Methods 8(9): 737--743 MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. [FBrf0216331] Show all research papers ...