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Gene: Dmel\tutl

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General Information
Symbol
Dmel\tutl
Species
D. melanogaster
Name
turtle
Annotation Symbol
CG15427
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010473
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Snapshot
Turtle (Tutl) is an Ig-superfamily transmembrane protein. Tutl roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control. [Date last reviewed: 2016-09-01]
Other Summaries
Also Known As
l(2)01085, jf4, mdcds_7441
Key Links
Genomic Location
Cytogenetic map
24E1-24E1
Sequence location
2L:4,283,148..4,323,781 [+]
Recombination map
2-12
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the immunoglobulin superfamily. Turtle family. (Q967D7)
Protein Domains/Motifs
InterPro
Immunoglobulin subtype 2; Immunoglobulin subtype; Fibronectin type III; Immunoglobulin-like domain; Immunoglobulin I-set; Immunoglobulin V-set domain; Immunoglobulin-like fold; Fibronectin type III superfamily; Immunoglobulin-like domain superfamily
Molecular Function (see GO section for details)
Experimental Evidence
cell-cell adhesion mediator activity
Predictions / Assertions
cell-cell adhesion mediator activity
Summaries
UniProt Contributed Function Data
Essential protein that plays a role in the establishment of coordinated motor control (PubMed:11312296). In the developing eye, involved in axonal targeting of the R7 photoreceptor (PubMed:24174674).
(UniProt, Q967D7)
Interactive Fly
Ig superfamily - ligand or co-receptor - required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors - regulates the tiling pattern of R7 photoreceptor terminals
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
8

Please see the GBrowse view of Dmel\tutl or the JBrowse view of Dmel\tutl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.55
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Alternative translation stop created by use of multiphasic reading frames within coding region.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tutl-RA
FBtr0089268
NM_164578
1874
377
tutl-RC
FBtr0089269
NM_164577
4595
903
tutl-RD
FBtr0089270
NM_164576
5179
1508
tutl-RE
FBtr0089271
NM_080127
3388
902
tutl-RF
FBtr0301863
NM_001169397
5250
963
tutl-RG
FBtr0301864
NM_001169398
5127
1508
tutl-RH
FBtr0333484
NM_001273090
7436
1533
tutl-RI
FBtr0333485
NM_001273091
7798
963
tutl-RJ
FBtr0347158
NM_001316378
5263
1536
tutl-RK
FBtr0347159
NM_001316379
5334
991
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
tutl-PA
FBpp0088325
41.9
377
8.04
NP_722969
AAF51031
tutl-PC
FBpp0088326
100.4
903
8.12
NP_722968
AAF51030
tutl-PD
FBpp0088327
168.2
1508
9.05
NP_722967
AAF51029
tutl-PE
FBpp0088328
100.5
902
8.12
NP_524866
AAN11173
tutl-PF
FBpp0291077
107.4
963
8.16
NP_001162868
ACZ94159
tutl-PG
FBpp0291078
168.2
1508
9.05
NP_001162869
ACZ94160
tutl-PH
FBpp0305668
171.1
1533
9.21
NP_001260019
AGB92555
tutl-PI
FBpp0305669
107.4
963
8.16
NP_001260020
AGB92556
tutl-PJ
FBpp0312489
171.5
1536
9.08
NP_001303307
ALI30193
tutl-PK
FBpp0312490
110.7
991
8.24
NP_001303308
ALI30194
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1508 aa isoforms: tutl-PD, tutl-PG
963 aa isoforms: tutl-PF, tutl-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with bdl.
(UniProt, Q967D7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tutl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (16 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cell-cell adhesion mediator activity
inferred from physical interaction with FLYBASE:bdl; FB:FBgn0028482
(Cameron et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cell-cell adhesion mediator activity
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (12 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
adult locomotory behavior
inferred from mutant phenotype
(Bodily et al., 2001)
axon guidance
inferred from mutant phenotype
(Al-Anzi and Wyman, 2009)
axon midline choice point recognition
inferred from mutant phenotype
(Al-Anzi and Wyman, 2009)
axonal defasciculation
inferred from mutant phenotype
(Al-Anzi and Wyman, 2009)
dendrite self-avoidance
inferred from mutant phenotype
(Long et al., 2009)
flight behavior
inferred from mutant phenotype
(Bodily et al., 2001)
larval behavior
inferred from mutant phenotype
(Bodily et al., 2001)
mechanosensory behavior
inferred from mutant phenotype
(Zhou et al., 2012)
R7 cell development
inferred from mutant phenotype
(Cameron et al., 2013)
inferred from genetic interaction with FLYBASE:bdl; FB:FBgn0028482
(Cameron et al., 2013)
regulation of dendrite morphogenesis
inferred from mutant phenotype
(Long et al., 2009)
synaptic target recognition
inferred from mutant phenotype
(Kurusu et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
dendrite self-avoidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
homophilic cell adhesion via plasma membrane adhesion molecules
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
axon
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
integral component of plasma membrane
inferred by curator from GO:0098632
(Cameron et al., 2013)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 14
embryonic/larval salivary gland
(Al-Anzi and Wyman, 2009)
embryonic/larval digestive system
(Al-Anzi and Wyman, 2009)
embryonic/larval glial cell
(Al-Anzi and Wyman, 2009)
embryonic stage 13 -- 16
atrium
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral midline
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
third instar larval stage
morphogenetic furrow
(Al-Anzi and Wyman, 2009)
eye disc | restricted

Comment: isoform-specific expression

(Al-Anzi and Wyman, 2009)
embryonic/larval brain
(Al-Anzi and Wyman, 2009)
embryonic/larval optic lobe
(Al-Anzi and Wyman, 2009)
adult optic lobe & optic nerve

Comment: isoform-specific expression

(Al-Anzi and Wyman, 2009)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 13
ventral midline
(Al-Anzi and Wyman, 2009)
embryonic stage 14 -- 17
embryonic/larval central nervous system
(Al-Anzi and Wyman, 2009)
Additional Descriptive Data
tutl expression is observed in the embryonic central nervous system, salivary glands and gut as well as in larval eye disc and brain. Isoform-specific levels and expression patterns are described.
(Al-Anzi and Wyman, 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuropil | subset of embryonic/larval central nervous system
(Zhou et al., 2012)
dorsal multidendritic neuron ddaC
(Long et al., 2009)
dorsal multidendritic neuron ddaB
(Long et al., 2009)
dorsal multidendritic neuron ddaA
(Long et al., 2009)
dorsal multidendritic neuron ddaF
(Long et al., 2009)
dorsal multidendritic neuron ddaD
(Long et al., 2009)
dorsal multidendritic neuron ddaE
(Long et al., 2009)
class I dendritic arborizing neuron
(Long et al., 2009)
class II dendritic arborizing neuron
(Long et al., 2009)
class III dendritic arborizing neuron
(Long et al., 2009)
class IV dendritic arborizing neuron
(Long et al., 2009)
pharate adult stage P8
lobula | restricted
(Ferguson et al., 2009)
lamina | restricted
(Ferguson et al., 2009)
adult optic lobe | restricted
(Ferguson et al., 2009)
pharate adult stage P9
lobula | restricted
(Ferguson et al., 2009)
lobula plate | restricted
(Ferguson et al., 2009)
lamina | restricted
(Ferguson et al., 2009)
adult optic lobe | restricted
(Ferguson et al., 2009)
adult stage
lobula | restricted
(Ferguson et al., 2009)
lobula plate | restricted
(Ferguson et al., 2009)
lamina | restricted
(Ferguson et al., 2009)
adult optic lobe | restricted
(Ferguson et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Expression of tutl protein is detected throughout the embryonic/larval nervous system.
(Zhou et al., 2012)
tutl is detected in cell bodies and along the dendrites of class I neurons ddaD and ddaE in third instar larvae. It is also observed in the cell body of class IV neuron ddaC, in the class I neuron ddaB, and in the class III neurons ddaA and ddaF. It is also expressed in other sensory neurons in the cluster.
(Long et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}tutlGAL4
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of embryonic/larval central nervous system
(Zhou et al., 2012)
class III dendritic arborizing neuron

Comment: not expressed in ddaF neurons

(Tsubouchi et al., 2012, Zhou et al., 2012)
Reporter: P{GMR91F06-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of central nervous system
(Zhou et al., 2012)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tutl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Allele of tutl
Class
Mutagen
Associated Insertion
Stocks
Known lesion
tutl01085
hypomorphic allele - genetic evidence
1
Yes
tutlk14703
hypomorphic allele - genetic evidence
2
Yes
tutl23
amorphic allele - genetic evidence
0
Yes
tutlf02770
    1
    Yes
    tutlf03096
    1
    Yes
    tutlMI00290
      1
      Yes
      tutljf4
        0
        --
        tutlMI00290-TG4.1
        1
        Yes
        tutl4
        loss of function allele
        0
        Yes
        tutl0474-G4
        1
        Yes
        tutlc00018
        1
        Yes
        tutlc06836
        1
        Yes
        tutlGS13843
          1
          Yes
          tutlMI00290-DV.1
          1
          Yes
          tutlMI00290-GFSTF.1
          1
          Yes
          tutlMI00290-mCh.1
          1
          Yes
          tutlMI08144
            1
            Yes
            tutl1
            hypomorphic allele - genetic evidence
            0
            Yes
            tutl2
            hypomorphic allele - genetic evidence
            0
            Yes
            tutl3
            hypomorphic allele - genetic evidence
            0
            Yes
            tutlex383
            0
            Yes
            tutlGAL4
            0
            Yes
            tutlMI00290-BM.1
            0
            Yes
            tutlMI00290-HS.1
            0
            Yes
            tutlMI00290-KV.1
            0
            Yes
            tutlunspecified
              0
              --
              Other relevant insertions
              Transgenic Constructs ( 13 )
              Deletions and Duplications ( 29 )
              Disrupted in
              Df(2L)dp-h28
              (Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)ed-dp
              (Al-Anzi and Wyman, 2009, Bodily et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)Exel8011
              (Ryder, 2004.4.26)
              Df(2L)M24F11
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)M24F-B
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-1
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-11
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)tutl-bdl
              (Cameron et al., 2013)
              Df(2L)tutl
              (Zhou et al., 2012)
              Not disrupted in
              Df(2L)dp-cl-h3
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)dp-h19
              (Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)dp-h24
              (Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)dp-h25
              (Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)ed1
              (Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)ED250
              (Mathew et al., 2009)
              Df(2L)ED251
              (Mathew et al., 2009)
              Df(2L)ED252
              (Mathew et al., 2009)
              Df(2L)ED3006-2L
              (Mathew et al., 2009)
              Df(2L)Exel6010
              (Mathew et al., 2009)
              Df(2L)Exel9062
              (Mathew et al., 2009)
              Df(2L)sc19-3
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-4
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-5
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-6
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-8
              (BDGP Project Members, 1994-1999)
              Df(2L)sc19-10
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-12
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)sc19-13
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Df(2L)tkv3
              (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
              Phenotypes
              For more details about a specific phenotype click on the relevant allele symbol.
              Lethality
              Allele
              lethal
              lethal (with Df(2L)BSC295)
              lethal | recessive
              lethal - all die before end of embryonic stage
              lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
              partially lethal - majority die
              partially lethal - majority live
              viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
              viable, with Scer\GAL4Mef2.PR
              viable, with Scer\GAL4pnr-MD237
              viable, with Scer\GAL4tin.CΔ4
              Other Phenotypes
              Allele
              behavior defective | adult stage | recessive
              behavior defective | larval stage (with Df(2L)ed-dp)
              behavior defective | larval stage (with Df(2L)tutl4)
              behavior defective | larval stage | recessive
              flightless | recessive
              locomotor behavior defective | larval stage | recessive
              neuroanatomy defective
              neuroanatomy defective, with Scer\GAL4elav-C155
              neuroanatomy defective, with Scer\GAL4G14
              neuroanatomy defective, with Scer\GAL4GMR.PF
              neuroanatomy defective, with Scer\GAL4how-24B
              neuroanatomy defective, with Scer\GAL4ppk.1.9
              neuroanatomy defective, with Scer\GAL4sca-109-68
              neuroanatomy defective, with Scer\GAL4sim.PS
              neuroanatomy defective, with Scer\GAL4tutl-GAL4
              neuroanatomy defective (with Df(2L)ed-dp)
              neuroanatomy defective (with tutl23)
              neuroanatomy defective (with tutl01085)
              neuroanatomy defective (with tutlex383)
              neuroanatomy defective (with tutlk14703)
              neuroanatomy defective | somatic clone
              pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
              some die during embryonic stage
              some die during pupal stage
              some die during pupal stage, with Scer\GAL4pnr-MD237
              touch response defective | third instar larval stage
              touch response defective | third instar larval stage (with Df(2L)tutl)
              touch response defective | third instar larval stage (with tutl23)
              touch response defective | third instar larval stage (with tutl01085)
              visible, with Scer\GAL4pnr-MD237
              Phenotype manifest in
              Allele
              adult optic lobe, with Scer\GAL4GMR.PF
              axon
              chaeta | supernumerary, with Scer\GAL4pnr-MD237
              commissure
              commissure, with Scer\GAL4elav-C155
              commissure, with Scer\GAL4sim.PS
              commissure (with Df(2L)ed-dp)
              dendrite & dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
              dendrite & dorsal multidendritic neuron ddaC (with tutl23)
              dendrite & dorsal multidendritic neuron ddaC (with tutl01085)
              dendrite & dorsal multidendritic neuron ddaC | somatic clone
              dendrite & dorsal multidendritic neuron ddaE
              dendrite & dorsal multidendritic neuron ddaE (with Df(2L)ed-dp)
              dendrite & dorsal multidendritic neuron ddaE (with tutl23)
              dendrite & dorsal multidendritic neuron ddaE (with tutl01085)
              dendrite & dorsal multidendritic neuron ddaE | somatic clone
              intermediate longitudinal fascicle
              intermediate longitudinal fascicle (with tutl01085)
              intermediate longitudinal fascicle (with tutlex383)
              intersegmental nerve branch ISNb of A1-7
              intersegmental nerve branch ISNd of A1-7
              intersegmental nerve branch ISNd of A1-7, with Scer\GAL4elav-C155
              intersegmental nerve branch ISNd of A1-7, with Scer\GAL4G14
              intersegmental nerve branch ISNd of A1-7, with Scer\GAL4how-24B
              intersegmental nerve branch ISNd of A1-7, with Scer\GAL4sca-109-68
              intersegmental nerve branch ISNd of A1-7, with Scer\GAL4sim.PS
              lateral longitudinal fascicle
              lateral longitudinal fascicle (with tutl01085)
              lateral longitudinal fascicle (with tutlex383)
              lateral medial fascicle
              lateral medial fascicle (with tutl01085)
              lateral medial fascicle (with tutlex383)
              longitudinal connective
              longitudinal connective, with Scer\GAL4elav-C155
              longitudinal connective, with Scer\GAL4sim.PS
              longitudinal connective (with Df(2L)ed-dp)
              medial longitudinal fascicle
              medial longitudinal fascicle (with tutl01085)
              medial longitudinal fascicle (with tutlex383)
              mesothoracic tergum, with Scer\GAL4pnr-MD237
              midline crossing tract
              midline crossing tract (with tutl01085)
              midline crossing tract (with tutlex383)
              neuropil, with Scer\GAL4elav-C155
              optic chiasma
              photoreceptor cell R7, with Scer\GAL4tutl-GAL4
              photoreceptor cell R7 (with tutl23)
              photoreceptor cell R7 (with tutlk14703)
              photoreceptor cell R7 | somatic clone
              photoreceptor cell R8 | somatic clone
              rhabdomere R7
              transverse nerve, with Scer\GAL4elav-C155
              transverse nerve, with Scer\GAL4G14
              transverse nerve, with Scer\GAL4how-24B
              transverse nerve, with Scer\GAL4sca-109-68
              transverse nerve, with Scer\GAL4sim.PS
              ventral nerve cord commissure
              ventral nerve cord commissure (with tutl01085)
              ventral nerve cord commissure (with tutlex383)
              Orthologs
              Downloads
              Download All DIOPT Orthologs
              Download All OrthoDB Orthologs
              Human Orthologs (via DIOPT v7.1)
              Homo sapiens (Human) (15)
              Species\Gene Symbol
              Score
              Best Score
              Best Reverse Score
              Source
              Compara
              eggNOG
              Hieranoid
              Homologene
              Inparanoid
              Isobase
              OMA
              OrthoDB
              OrthoFinder
              OrthoInspector
              orthoMCL
              Panther
              Phylome
              RoundUp
              TreeFam
              ZFIN
              Alignment
              Complementation?
              Transgene?
              Hsap\IGSF9B
              9 of 15
              Yes
              Yes
              Hsap\IGSF9
              9 of 15
              Yes
              Yes
              Hsap\KIRREL1
              1 of 15
              No
              No
              Hsap\KIRREL2
              1 of 15
              No
              No
              Hsap\KIRREL3
              1 of 15
              No
              No
              Hsap\LRIT1
              1 of 15
              No
              No
              Hsap\LRIT3
              1 of 15
              No
              No
              Hsap\MDGA1
              1 of 15
              No
              No
              Hsap\MDGA2
              1 of 15
              No
              No
              Hsap\MFAP3
              1 of 15
              No
              Yes
              Hsap\MYPN
              1 of 15
              No
              No
              Hsap\PALLD
              1 of 15
              No
              No
              Hsap\PAPLN
              1 of 15
              No
              No
              Hsap\SDK1
              1 of 15
              No
              No
              Hsap\USH2A
              1 of 15
              No
              Yes
              Model Organism Orthologs (via DIOPT v7.1)
              Mus musculus (laboratory mouse) (15)
              Species\Gene Symbol
              Score
              Best Score
              Best Reverse Score
              Source
              Compara
              eggNOG
              Hieranoid
              Homologene
              Inparanoid
              Isobase
              OMA
              OrthoDB
              OrthoFinder
              OrthoInspector
              orthoMCL
              Panther
              Phylome
              RoundUp
              TreeFam
              ZFIN
              Alignment
              Complementation?
              Transgene?
              Mmus\Igsf9
              9 of 15
              Yes
              Yes
              Mmus\Igsf9b
              8 of 15
              No
              Yes
              Mmus\Kirrel2
              1 of 15
              No
              No
               
              Mmus\Kirrel3
              1 of 15
              No
              No
               
              Mmus\Kirrel
              1 of 15
              No
              No
               
              Mmus\Lrit1
              1 of 15
              No
              No
              Mmus\Lrit3
              1 of 15
              No
              No
              Mmus\Mdga1
              1 of 15
              No
              No
              Mmus\Mdga2
              1 of 15
              No
              No
              Mmus\Myot
              1 of 15
              No
              Yes
              Mmus\Mypn
              1 of 15
              No
              No
              Mmus\Nrcam
              1 of 15
              No
              No
              Mmus\Papln
              1 of 15
              No
              No
              Mmus\Ptprq
              1 of 15
              No
              Yes
              Mmus\Sdk1
              1 of 15
              No
              No
              Rattus norvegicus (Norway rat) (13)
              Rnor\Igsf9b
              9 of 13
              Yes
              Yes
              Rnor\Igsf9
              8 of 13
              No
              Yes
              Rnor\Kirrel1
              1 of 13
              No
              No
              Rnor\Kirrel2
              1 of 13
              No
              No
              Rnor\Kirrel3
              1 of 13
              No
              No
              Rnor\LOC100360205
              1 of 13
              No
              Yes
              Rnor\Lrit1
              1 of 13
              No
              No
              Rnor\Mdga1
              1 of 13
              No
              No
              Rnor\Mdga2
              1 of 13
              No
              No
              Rnor\Mfap3
              1 of 13
              No
              Yes
              Rnor\Myot
              1 of 13
              No
              Yes
              Rnor\Nrcam
              1 of 13
              No
              No
               
              Rnor\Opcml
              1 of 13
              No
              No
              Xenopus tropicalis (Western clawed frog) (7)
              Xtro\igsf9b
              5 of 12
              Yes
              Yes
              Xtro\igsf9
              4 of 12
              No
              No
              Xtro\kirrel2
              1 of 12
              No
              No
              Xtro\lrit3
              1 of 12
              No
              Yes
              Xtro\mdga2
              1 of 12
              No
              Yes
              Xtro\mfap3
              1 of 12
              No
              Yes
              Xtro\papln
              1 of 12
              No
              No
              Danio rerio (Zebrafish) (25)
              Drer\igsf9bb
              10 of 15
              Yes
              Yes
              Drer\igsf9a
              9 of 15
              No
              Yes
              Drer\igsf9ba
              7 of 15
              No
              Yes
              Drer\igsf9b
              6 of 15
              No
              Yes
              Drer\dscama
              1 of 15
              No
              No
              Drer\dscamb
              1 of 15
              No
              No
              Drer\itgb4
              1 of 15
              No
              No
              Drer\kirrel1a
              1 of 15
              No
              No
              Drer\kirrel1b
              1 of 15
              No
              No
              Drer\kirrel3a
              1 of 15
              No
              No
              Drer\kirrel3b
              1 of 15
              No
              No
              Drer\kirrel3l
              1 of 15
              No
              No
              Drer\lrit1a
              1 of 15
              No
              No
              Drer\lrit1b
              1 of 15
              No
              No
              Drer\lrit3a
              1 of 15
              No
              No
              Drer\lrit3b
              1 of 15
              No
              No
              Drer\mybpha
              1 of 15
              No
              No
              Drer\mybphb
              1 of 15
              No
              No
              Drer\ncam1b
              1 of 15
              No
              No
              Drer\paplna
              1 of 15
              No
              No
              Drer\sdk1a
              1 of 15
              No
              No
              Drer\sdk1b
              1 of 15
              No
              No
              Drer\si:ch1073-459j12.1
              1 of 15
              No
              No
              Drer\si:dkeyp-97a10.3
              1 of 15
              No
              Yes
              Drer\ush2a
              1 of 15
              No
              Yes
              Caenorhabditis elegans (Nematode, roundworm) (12)
              Cele\igcm-2
              6 of 15
              Yes
              Yes
              Cele\C53A5.13
              1 of 15
              No
              Yes
              Cele\ncam-1
              1 of 15
              No
              No
              Cele\rig-3
              1 of 15
              No
              Yes
              Cele\T04C9.3
              1 of 15
              No
              Yes
              Cele\zig-1
              1 of 15
              No
              Yes
              Cele\zig-2
              1 of 15
              No
              No
              Cele\zig-3
              1 of 15
              No
              No
              Cele\zig-4
              1 of 15
              No
              No
              Cele\zig-6
              1 of 15
              No
              Yes
              Cele\zig-7
              1 of 15
              No
              Yes
              Cele\zig-11
              1 of 15
              No
              Yes
              Arabidopsis thaliana (thale-cress) (0)
              No orthologs reported.
              Saccharomyces cerevisiae (Brewer's yeast) (0)
              No orthologs reported.
              Schizosaccharomyces pombe (Fission yeast) (0)
              No orthologs reported.
              Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900MQ )
              Organism
              Common Name
              Gene
              AAA Syntenic Ortholog
              Multiple Dmel Genes in this Orthologous Group
              Drosophila melanogaster
              fruit fly
              Dmel\tutl
              Drosophila suzukii
              Spotted wing Drosophila
              Dsuz\DS10_00000103
              Drosophila simulans
              Dsim\GD23274
              Drosophila sechellia
              Dsec\GM18461
              Drosophila erecta
              Dere\GG24990
              Drosophila yakuba
              Dyak\GE18278
              Drosophila ananassae
              Dana\GF15018
              Drosophila pseudoobscura pseudoobscura
              Dpse\GA13718
              Drosophila persimilis
              Dper\GL14010
              Drosophila willistoni
              Dwil\GK24611
              Drosophila virilis
              Dvir\GJ16222
              Drosophila mojavensis
              Dmoj\GI13998
              Drosophila grimshawi
              Dgri\GH10066
              Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FB )
              Organism
              Common Name
              Gene
              Multiple Dmel Genes in this Orthologous Group
              Musca domestica
              House fly
              Mdoa\17022412
              Glossina morsitans
              Tsetse fly
              Gmor\GMOY001681
              Mayetiola destructor
              Hessian fly
              Mdes\Mdes005074
              Aedes aegypti
              Yellow fever mosquito
              Aaeg\AAEL006522
              Anopheles darlingi
              American malaria mosquito
              Adar\ADAC006214
              Anopheles gambiae
              Malaria mosquito
              Agam\AGAP007928
              Culex quinquefasciatus
              Southern house mosquito
              Cqui\CPIJ002412
              Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0164 )
              Organism
              Common Name
              Gene
              Multiple Dmel Genes in this Orthologous Group
              Bombyx mori
              Silkmoth
              Bmor\BGIBMGA010354
              Danaus plexippus
              Monarch butterfly
              Dple\DPOGS208540-PA
              Heliconius melpomene
              Postman butterfly
              Hmel\HMEL008751
              Apis florea
              Little honeybee
              Aflo\2213828628
              Apis mellifera
              Western honey bee
              Amel\GB53012
              Bombus impatiens
              Common eastern bumble bee
              Bimp\BIMP10510
              Bombus impatiens
              Common eastern bumble bee
              Bimp\BIMP10511
              Bombus terrestris
              Buff-tailed bumblebee
              Bter\15204856
              Linepithema humile
              Argentine ant
              Lhum\LH17792
              Linepithema humile
              Argentine ant
              Lhum\LH17790
              Linepithema humile
              Argentine ant
              Lhum\LH17791
              Megachile rotundata
              Alfalfa leafcutting bee
              Mrot\MROTU:0021b2
              Nasonia vitripennis
              Parasitic wasp
              Nvit\Nasvi2EG011343
              Dendroctonus ponderosae
              Mountain pine beetle
              Dpod\YQE_02237
              Tribolium castaneum
              Red flour beetle
              Tcas\GLEAN_08291
              Pediculus humanus
              Human body louse
              Phum\PHUM322860
              Rhodnius prolixus
              Kissing bug
              Rpro\RPRC002888
              Cimex lectularius
              Bed bug
              Clec\CLEC006108
              Cimex lectularius
              Bed bug
              Clec\CLEC006107
              Acyrthosiphon pisum
              Pea aphid
              Apim\ACYPI068599
              Zootermopsis nevadensis
              Nevada dampwood termite
              Znev\Znev_08324
              Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X043P )
              Organism
              Common Name
              Gene
              Multiple Dmel Genes in this Orthologous Group
              Strigamia maritima
              European centipede
              Smar\SMAR010812
              Ixodes scapularis
              Black-legged tick
              Isca\ISCW020695
              Stegodyphus mimosarum
              African social velvet spider
              Smim\KFM82622.1
              Stegodyphus mimosarum
              African social velvet spider
              Smim\KFM67280.1
              Stegodyphus mimosarum
              African social velvet spider
              Smim\KFM65985.1
              Tetranychus urticae
              Two-spotted spider mite
              Turt\tetur06g05950
              Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02TX )
              Organism
              Common Name
              Gene
              Multiple Dmel Genes in this Orthologous Group
              Strongylocentrotus purpuratus
              Purple sea urchin
              Spur\Sp-Fn3f_4
              Strongylocentrotus purpuratus
              Purple sea urchin
              Spur\Sp-Fn3/Ig_1
              Ciona intestinalis
              Vase tunicate
              Cint\ENSCING00000004965
              Gallus gallus
              Domestic chicken
              Ggal\ENSGALG00000001450
              Gallus gallus
              Domestic chicken
              Ggal\ENSGALG00000022603
              Human Disease Model Data
              FlyBase Human Disease Model Reports
                Alleles Reported to Model Human Disease (Disease Ontology)
                Download
                Models ( 0 )
                Allele
                Disease
                Evidence
                References
                Interactions ( 0 )
                Allele
                Disease
                Interaction
                References
                Comments ( 0 )
                 
                Human Orthologs (via DIOPT v7.1)
                Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
                Homo sapiens (Human)
                Gene name
                Score
                OMIM
                OMIM Phenotype
                Complementation?
                Transgene?
                IGSF9B; immunoglobulin superfamily member 9B
                9 of 15
                613773
                  IGSF9; immunoglobulin superfamily member 9
                  9 of 15
                  609738
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please look at the Interaction Group reports for full details of the physical interactions
                    protein-protein
                    Interacting group
                    Assay
                    References
                    tutl
                    bead aggregation assay, fluorescence microscopy, inferred by author
                    (Ferguson et al., 2009)
                    tutl - bdl
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Cameron et al., 2013)
                    tutl - ed
                    enzyme linked immunosorbent assay
                    (Ozkan et al., 2013)
                    RNA-RNA
                    Interacting group
                    Assay
                    References
                    tutl - mir-1
                    luminiscence technology
                    (Robins et al., 2005)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    tutl
                    suppressible
                    bdl
                    (Cameron et al., 2013)
                    tutl
                    enhanceable
                    Kap-α3
                    (Ferguson et al., 2009)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Actβ
                    enhanceable
                    tutl
                    (Ferguson et al., 2009)
                    fra
                    enhanceable
                    tutl
                    (Al-Anzi and Wyman, 2009)
                    H
                    suppressible
                    tutl
                    (Müller et al., 2005)
                    Kap-α3
                    enhanceable
                    tutl
                    (Ferguson et al., 2009)
                    mbl
                    enhanceable
                    tutl
                    (Vicente-Crespo et al., 2008)
                    mbl
                    suppressible
                    tutl
                    (Vicente-Crespo et al., 2008)
                    peb
                    suppressible
                    tutl
                    (Wilk et al., 2004)
                    External Data
                    Subunit Structure (UniProtKB)
                    Interacts with bdl.
                    (UniProt, Q967D7 )
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    Pathways
                    Gene Group - Pathway Membership (FlyBase)
                    External Data
                    Linkouts
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2L
                    Recombination map
                    2-12
                    Cytogenetic map
                    24E1-24E1
                    Sequence location
                    2L:4,283,148..4,323,781 [+]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    24E1-24E1
                    Limits computationally determined from genome sequence between P{lacW}edk01102 and P{PZ}tutl01085
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    24E1-24E2
                    (determined by in situ hybridisation)
                    (Spradling et al., 1999)
                    24E1-24E2
                    (BDGP Project Members, 1994-1999)
                    Experimentally Determined Recombination Data
                    Location
                    2-12
                    (FlyBase, 2016)
                    2-12.8
                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (21)
                    Genomic Clones (47)
                    cDNA Clones (83)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequences
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    polyclonal
                    (Zhou et al., 2012, Sulkowski et al., 2011, Ferguson et al., 2009, Long et al., 2009)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for identity of: tutl l(2)01085 CG15427 CG15428
                    (Broadie, 2001.5.8)
                    Source for identity of: tutl l(2)01085 CG15426 CG15427
                    (FlyBase, 1996-)
                    Source for database merge of
                    Source for merge of: l(2)01085 CG15426
                    (Misra, 2000.8.25)
                    Source for merge of: tutl l(2)01085 CG15427
                    (Bodily et al., 2001)
                    Source for merge of: tutl l(2)24Df
                    (Dean, 2003.6.5)
                    Additional comments
                    Source for identity of tutl l(2)01085 CG15426 CG15427 was sequence comparison ( date:010521 ).
                    (FlyBase, 1996-)
                    Other Comments
                    A small subset of tutl-positive neurons are required for modulating directional change in response to gentle touch in larvae.
                    (Zhou et al., 2012)
                    tutl promotes midline attraction via a netrin-independent mechanism, ad not as part of the netrin signaling pathway.
                    (Al-Anzi and Wyman, 2009)
                    tutl promotes both motor and retinal axon branching and invasive behavior.
                    (Al-Anzi and Wyman, 2009)
                    tutl has a cell-autonomous role in specifying R7 axonal tiling (in parallel with Actβ).
                    (Ferguson et al., 2009)
                    tutl restricts dendrite branching in neurons with simple arbors and promotes self-avoidance in neurons with highly complex arbors.
                    (Long et al., 2009)
                    Mutations in tutl result in an abnormal response to tactile stimulation, the inability to regain an upright position from an inverted position, and the inability to fly in adulthood.
                    (Bodily et al., 2001)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    The gene is named "turtle" after the mutant phenotype; mutants are unable to regain an upright position from an inverted position.
                    (Bodily et al., 2001)
                    Identification
                    External Crossreferences and Linkouts ( 86 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    InterPro - A database of protein families, domains and functional sites
                    Linkouts
                    ApoDroso - Functional genomic database for photoreceptor development, survival and function
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    FlyMine - An integrated database for Drosophila genomics
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    modMine - A data warehouse for the modENCODE project
                    Synonyms and Secondary IDs (15)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (93)