l(2)01085, jf4, mdcds_7441
Ig superfamily - ligand or co-receptor - required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors - regulates the tiling pattern of R7 photoreceptor terminals
Please see the GBrowse view of Dmel\tutl or the JBrowse view of Dmel\tutl for information on other features
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Gene model reviewed during 5.55
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Alternative translation stop created by use of multiphasic reading frames within coding region.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.02
Interacts with bdl.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tutl using the Feature Mapper tool.
Comment: anlage in statu nascendi
tutl expression is observed in the embryonic central nervous system, salivary glands and gut as well as in larval eye disc and brain. Isoform-specific levels and expression patterns are described.
Comment: moderate
Expression of tutl protein is detected throughout the embryonic/larval nervous system.
tutl is detected in da neurons with the highest levels in class III and class IV da neurons, moderate levels in class II and low levels in class I da neurons. Localization is also seen in da neuron dendrites and axons.
tutl is detected in cell bodies and along the dendrites of class I neurons ddaD and ddaE in third instar larvae. It is also observed in the cell body of class IV neuron ddaC, in the class I neuron ddaB, and in the class III neurons ddaA and ddaF. It is also expressed in other sensory neurons in the cluster.
Comment: not expressed in ddaF neurons
GBrowse - Visual display of RNA-Seq signals
View Dmel\tutl in GBrowse 2
2-12
2-12
2-12.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: tutl l(2)01085 CG15427 CG15428
Source for identity of: tutl l(2)01085 CG15426 CG15427
Source for merge of: l(2)01085 CG15426
Source for merge of: tutl l(2)01085 CG15427
Source for merge of: tutl l(2)24Df
Source for identity of tutl l(2)01085 CG15426 CG15427 was sequence comparison ( date:010521 ).
A small subset of tutl-positive neurons are required for modulating directional change in response to gentle touch in larvae.
tutl promotes midline attraction via a netrin-independent mechanism, ad not as part of the netrin signaling pathway.
tutl promotes both motor and retinal axon branching and invasive behavior.
tutl restricts dendrite branching in neurons with simple arbors and promotes self-avoidance in neurons with highly complex arbors.
Mutations in tutl result in an abnormal response to tactile stimulation, the inability to regain an upright position from an inverted position, and the inability to fly in adulthood.
The gene is named "turtle" after the mutant phenotype; mutants are unable to regain an upright position from an inverted position.
