FlyBase Gene Report: Dmel\tutl

General Information

Symbol

Dmel\tutl

Species

D. melanogaster

Name

turtle

Annotation Symbol

CG15427

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010473

Gene Model Status

Stock Availability

12 publicly available

Gene Summary

turtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(2)01085, jf4, mdcds_7441

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:4,283,148..4,323,781 [+]

Recombination map

2-12

RefSeq locus

NT_033779 REGION:4283148..4323781

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cell-cell adhesion mediator activity

inferred from physical interaction with FLYBASE:bdl; FB:FBgn0028482

(Cameron et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cell-cell adhesion mediator activity

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (12 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(Bodily et al., 2001)

involved_in axon guidance

inferred from mutant phenotype

(Al-Anzi and Wyman, 2009)

involved_in axon midline choice point recognition

inferred from mutant phenotype

(Al-Anzi and Wyman, 2009)

involved_in axonal defasciculation

inferred from mutant phenotype

(Al-Anzi and Wyman, 2009)

involved_in dendrite self-avoidance

inferred from mutant phenotype

(Long et al., 2009)

involved_in flight behavior

inferred from mutant phenotype

(Bodily et al., 2001)

involved_in larval behavior

inferred from mutant phenotype

(Bodily et al., 2001)

involved_in mechanosensory behavior

inferred from mutant phenotype

(Zhou et al., 2012)

involved_in R7 cell development

inferred from mutant phenotype

(Cameron et al., 2013)

inferred from genetic interaction with FLYBASE:bdl; FB:FBgn0028482

(Cameron et al., 2013)

involved_in regulation of dendrite morphogenesis

inferred from mutant phenotype

(Long et al., 2009)

involved_in synaptic target recognition

inferred from mutant phenotype

(Kurusu et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in dendrite self-avoidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in homophilic cell adhesion via plasma membrane adhesion molecules

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in axon

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in integral component of plasma membrane

inferred by curator from GO:0098632

(Cameron et al., 2013)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the immunoglobulin superfamily. Turtle family. (Q967D7)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

turtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control. [Date last reviewed: 2019-03-14]

Protein Function (UniProtKB)

Essential protein that plays a role in the establishment of coordinated motor control (PubMed:11312296). In the developing eye, involved in axonal targeting of the R7 photoreceptor (PubMed:24174674).

(UniProt, Q967D7)

Summary (Interactive Fly)

Ig superfamily - ligand or co-receptor - required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors - regulates the tiling pattern of R7 photoreceptor terminals

Interactive Fly

Gene Model and Products

Number of Transcripts

10

Number of Unique Polypeptides

8

Please see the JBrowse view of Dmel\tutl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0089268

1874

377

FBtr0089269

4595

903

FBtr0089270

5179

1508

FBtr0089271

3388

902

FBtr0301863

5250

963

FBtr0301864

5127

1508

FBtr0333484

7436

1533

FBtr0333485

7798

963

FBtr0347158

5263

1536

FBtr0347159

5334

991

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0088325

41.9

377

8.04

FBpp0088326

100.4

903

8.12

FBpp0088327

168.2

1508

9.05

FBpp0088328

100.5

902

8.12

FBpp0291077

107.4

963

8.16

FBpp0291078

168.2

1508

9.05

FBpp0305668

171.1

1533

9.21

FBpp0305669

107.4

963

8.16

FBpp0312489

171.5

1536

9.08

FBpp0312490

110.7

991

8.24

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1508 aa isoforms: tutl-PD, tutl-PG

963 aa isoforms: tutl-PF, tutl-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with bdl.

(UniProt, Q967D7)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tutl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

dorsal ectoderm

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 14

embryonic/larval salivary gland

(Al-Anzi and Wyman, 2009)

embryonic/larval digestive system

(Al-Anzi and Wyman, 2009)

embryonic/larval glial cell

(Al-Anzi and Wyman, 2009)

third instar larval stage

morphogenetic furrow

(Al-Anzi and Wyman, 2009)

eye disc | restricted

Comment: isoform-specific expression

(Al-Anzi and Wyman, 2009)

embryonic/larval brain

(Al-Anzi and Wyman, 2009)

embryonic/larval optic lobe

(Al-Anzi and Wyman, 2009)

adult optic lobe & optic nerve

Comment: isoform-specific expression

(Al-Anzi and Wyman, 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 13

ventral midline of embryo

(Al-Anzi and Wyman, 2009)

embryonic stage 14 -- 17

embryonic/larval central nervous system

(Al-Anzi and Wyman, 2009)

Additional Descriptive Data

tutl expression is observed in the embryonic central nervous system, salivary glands and gut as well as in larval eye disc and brain. Isoform-specific levels and expression patterns are described.

(Al-Anzi and Wyman, 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

neuropil | subset of embryonic/larval central nervous system

(Zhou et al., 2012)

larval dorsal multidendritic neuron ddaC

(Long et al., 2009)

larval dorsal multidendritic neuron ddaB

(Long et al., 2009)

larval dorsal multidendritic neuron ddaA

(Long et al., 2009)

larval dorsal multidendritic neuron ddaF

(Long et al., 2009)

larval dorsal multidendritic neuron ddaD

(Long et al., 2009)

larval dorsal multidendritic neuron ddaE

(Long et al., 2009)

larval multidendritic class I neuron

Comment: weak

low levels

(Sulkowski et al., 2011, Long et al., 2009)

larval multidendritic class II neuron

Comment: moderate

moderate levels

(Sulkowski et al., 2011, Long et al., 2009)

larval multidendritic class III neuron

Comment: high

high levels

(Sulkowski et al., 2011, Long et al., 2009)

larval multidendritic class IV neuron

Comment: high

high levels

(Sulkowski et al., 2011, Long et al., 2009)

pharate adult stage P8

lobula | restricted

(Ferguson et al., 2009)

lamina | restricted

(Ferguson et al., 2009)

adult optic lobe | restricted

(Ferguson et al., 2009)

pharate adult stage P9

lobula | restricted

(Ferguson et al., 2009)

lobula plate | restricted

(Ferguson et al., 2009)

lamina | restricted

(Ferguson et al., 2009)

adult optic lobe | restricted

(Ferguson et al., 2009)

lobula | restricted

(Ferguson et al., 2009)

lobula plate | restricted

(Ferguson et al., 2009)

lamina | restricted

(Ferguson et al., 2009)

adult optic lobe | restricted

(Ferguson et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Expression of tutl protein is detected throughout the embryonic/larval nervous system.

(Zhou et al., 2012)

tutl is detected in da neurons with the highest levels in class III and class IV da neurons, moderate levels in class II and low levels in class I da neurons. Localization is also seen in da neuron dendrites and axons.

(Sulkowski et al., 2011)

Differential levels of tutl protein expression are observed in da neuron cell bodies with the highest levels in class III and class IV da neurons, moderate levels in class II da neurons and low levels in class I da neurons. tutl protein localizes to both dendrites and axons of da neurons.

(Sulkowski et al., 2011)

tutl is detected in cell bodies and along the dendrites of class I neurons ddaD and ddaE in third instar larvae. It is also observed in the cell body of class IV neuron ddaC, in the class I neuron ddaB, and in the class III neurons ddaA and ddaF. It is also expressed in other sensory neurons in the cluster.

(Long et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{GawB}tutl^GAL4

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

neuron | subset of embryonic/larval central nervous system

(Zhou et al., 2012)

larval multidendritic class III neuron

Comment: not expressed in ddaF neurons

(Tsubouchi et al., 2012, Zhou et al., 2012)

dorsal group dA neuron

(Sulkowski et al., 2011)

larval dorsal multidendritic neuron ddaF

Comment: high levels

(Sulkowski et al., 2011)

larval dorsal multidendritic neuron ddaC

Comment: high levels

(Sulkowski et al., 2011)

larval dorsal multidendritic neuron ddaA

Comment: high levels

(Sulkowski et al., 2011)

larval dorsal multidendritic neuron ddaB

Comment: intermediate levesl

(Sulkowski et al., 2011)

larval dorsal multidendritic neuron ddaD

Comment: low levels

(Sulkowski et al., 2011)

larval dorsal multidendritic neuron ddaE

Comment: low levels

(Sulkowski et al., 2011)

Reporter: P{GMR91F06-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

neuron | subset of central nervous system

(Zhou et al., 2012)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tutl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\tutl

View exonic expression by tissue for Dmel\tutl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010473

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46015/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010473

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010473

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010473

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15427

Flygut - An atlas of the Drosophila adult midgut

FBgn0010473

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\tutl

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 26 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of tutl

Transgenic constructs containing regulatory region of tutl

Aberrations (Deficiencies and Duplications) ( 29 )

Inferred from experimentation ( 29 )

Gene not disrupted in

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Mathew et al., 2009, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Mathew et al., 2009)

(Mathew et al., 2009)

(Mathew et al., 2009)

Df(2L)ED3006-2L

(Mathew et al., 2009)

(Mathew et al., 2009)

(Mathew et al., 2009)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(BDGP Project Members, 1994-1999)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)BSC295)

tutl^{MI00290-TG4.1}

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

tutl^GD14357

lethal - all die during embryonic stage

tutl^ex383

partially lethal - majority die

tutl^k14703

partially lethal - majority live

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

tutl^GD2558

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal behavior | adult stage | recessive

abnormal behavior | larval stage (with Df(2L)ed-dp)

abnormal behavior | larval stage (with Df(2L)tutl⁴)

abnormal behavior | larval stage | recessive

abnormal locomotor behavior | larval stage | recessive

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^elav-C155

abnormal neuroanatomy, with Scer\GAL4^G14

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

abnormal neuroanatomy, with Scer\GAL4^how-24B

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

tutl^RE40452.UAS

abnormal neuroanatomy, with Scer\GAL4^sca-109-68

abnormal neuroanatomy, with Scer\GAL4^sim.PS

abnormal neuroanatomy, with Scer\GAL4^tutl-GAL4

tutl^{dsRNA.400.UAS}

abnormal neuroanatomy (with Df(2L)ed-dp)

abnormal neuroanatomy (with tutl²³)

abnormal neuroanatomy (with tutl⁰¹⁰⁸⁵)

abnormal neuroanatomy (with tutl^ex383)

tutl⁰¹⁰⁸⁵

abnormal neuroanatomy (with tutl^k14703)

tutl²³

abnormal neuroanatomy | somatic clone

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

tutl^GD14357

abnormal touch response | third instar larval stage

tutl²³

abnormal touch response | third instar larval stage (with Df(2L)tutl)

abnormal touch response | third instar larval stage (with tutl²³)

tutl⁰¹⁰⁸⁵

abnormal touch response | third instar larval stage (with tutl⁰¹⁰⁸⁵)

tutl²³

flightless | recessive

some die during embryonic stage

tutl^ex383

some die during pupal stage

tutl^k14703

some die during pupal stage, with Scer\GAL4^pnr-MD237

tutl^GD14357

visible, with Scer\GAL4^pnr-MD237

tutl^GD14357

Phenotype manifest in

Allele

adult optic lobe, with Scer\GAL4^GMR.PF

tutl²³

chaeta | increased number, with Scer\GAL4^pnr-MD237

tutl^GD14357

tutl⁰¹⁰⁸⁵

commissure (with tutl⁰¹⁰⁸⁵)

tutl^ex383

commissure (with tutl^ex383)

tutl⁰¹⁰⁸⁵

dendrite & dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

tutl^RE40452.UAS

dendrite & dorsal multidendritic neuron ddaC (with tutl²³)

tutl⁰¹⁰⁸⁵

dendrite & dorsal multidendritic neuron ddaC (with tutl⁰¹⁰⁸⁵)

tutl²³

dendrite & dorsal multidendritic neuron ddaC | somatic clone

tutl²³

dendrite & dorsal multidendritic neuron ddaE

tutl²³

dendrite & dorsal multidendritic neuron ddaE (with Df(2L)ed-dp)

dendrite & dorsal multidendritic neuron ddaE (with tutl²³)

tutl⁰¹⁰⁸⁵

dendrite & dorsal multidendritic neuron ddaE (with tutl⁰¹⁰⁸⁵)

tutl²³

dendrite & dorsal multidendritic neuron ddaE | somatic clone

tutl²³

intermediate longitudinal fascicle

tutl⁰¹⁰⁸⁵

intermediate longitudinal fascicle (with tutl⁰¹⁰⁸⁵)

tutl^ex383

intermediate longitudinal fascicle (with tutl^ex383)

tutl⁰¹⁰⁸⁵

larval intersegmental nerve branch ISNb of A1-7

larval intersegmental nerve branch ISNd of A1-7

larval intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^elav-C155

larval intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^G14

larval intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^how-24B

larval intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^sca-109-68

larval intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^sim.PS

larval longitudinal connective

tutl^ex383

larval longitudinal connective, with Scer\GAL4^elav-C155

larval longitudinal connective, with Scer\GAL4^sim.PS

larval longitudinal connective (with Df(2L)ed-dp)

tutl^ex383

larval transverse nerve, with Scer\GAL4^elav-C155

larval transverse nerve, with Scer\GAL4^G14

larval transverse nerve, with Scer\GAL4^how-24B

larval transverse nerve, with Scer\GAL4^sca-109-68

larval transverse nerve, with Scer\GAL4^sim.PS

larval ventral nerve cord commissure

tutl⁰¹⁰⁸⁵

larval ventral nerve cord commissure (with tutl⁰¹⁰⁸⁵)

tutl^ex383

larval ventral nerve cord commissure (with tutl^ex383)

tutl⁰¹⁰⁸⁵

lateral longitudinal fascicle

tutl⁰¹⁰⁸⁵

lateral longitudinal fascicle (with tutl⁰¹⁰⁸⁵)

tutl^ex383

lateral longitudinal fascicle (with tutl^ex383)

tutl⁰¹⁰⁸⁵

lateral medial fascicle

tutl⁰¹⁰⁸⁵

lateral medial fascicle (with tutl⁰¹⁰⁸⁵)

tutl^ex383

lateral medial fascicle (with tutl^ex383)

tutl⁰¹⁰⁸⁵

medial longitudinal fascicle

tutl⁰¹⁰⁸⁵

medial longitudinal fascicle (with tutl⁰¹⁰⁸⁵)

tutl^ex383

medial longitudinal fascicle (with tutl^ex383)

tutl⁰¹⁰⁸⁵

mesothoracic tergum, with Scer\GAL4^pnr-MD237

tutl^GD14357

neuropil, with Scer\GAL4^elav-C155

tutl^AT02763.UAS

tutl^k14703

photoreceptor cell R7, with Scer\GAL4^tutl-GAL4

tutl^{dsRNA.400.UAS}

photoreceptor cell R7 (with tutl²³)

tutl^k14703

photoreceptor cell R7 (with tutl^k14703)

tutl²³

photoreceptor cell R7 | somatic clone

tutl⁰¹⁰⁸⁵

photoreceptor cell R8 | somatic clone

tutl⁰¹⁰⁸⁵

tutl²³

symmetrical commissure

tutl^ex383

symmetrical commissure, with Scer\GAL4^elav-C155

symmetrical commissure, with Scer\GAL4^sim.PS

symmetrical commissure (with Df(2L)ed-dp)

tutl^ex383

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (23)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

2

9 of 15

No

Yes

1 of 15

No

No

3

1 of 15

No

No

2

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

4

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

9 of 15

Yes

Yes

9 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1

1 of 15

No

No

1

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (17)

10 of 13

Yes

Yes

9 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (13)

5 of 12

Yes

Yes

5 of 12

Yes

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (32)

10 of 15

Yes

Yes

10 of 15

Yes

Yes

8 of 15

No

Yes

7 of 15

No

Yes

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:ch1073-459j12.1

1 of 15

No

No

Drer\si:dkeyp-75h12.2

1 of 15

No

No

1 of 15

No

Yes

Drer\zgc:110372

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (13)

7 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900MQ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00000103

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY001681

Mayetiola destructor

Hessian fly

Mdes\Mdes005074

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006522

Anopheles darlingi

American malaria mosquito

Adar\ADAC006214

Anopheles gambiae

Malaria mosquito

Agam\AGAP007928

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002412

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0164 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010354

Danaus plexippus

Monarch butterfly

Dple\DPOGS208540-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008751

Apis florea

Little honeybee

Aflo\2213828628

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0021b2

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011343

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08291

Pediculus humanus

Human body louse

Phum\PHUM322860

Rhodnius prolixus

Kissing bug

Rpro\RPRC002888

Cimex lectularius

Bed bug

Clec\CLEC006108

Cimex lectularius

Bed bug

Clec\CLEC006107

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI068599

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08324

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X043P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR010812

Ixodes scapularis

Black-legged tick

Isca\ISCW020695

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82622.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67280.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65985.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g05950

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02TX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Ig_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004965

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001450

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000022603

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (60)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

IGSF9; immunoglobulin superfamily member 9

12 of 15

IGSF9B; immunoglobulin superfamily member 9B

9 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bead aggregation assay, fluorescence microscopy, inferred by author

(Ferguson et al., 2009)

anti tag coimmunoprecipitation, anti tag western blot

(Cameron et al., 2013)

enzyme linked immunosorbent assay

(Ozkan et al., 2013)

RNA-RNA

Physical Interaction

Assay

References

luminiscence technology

(Robins et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Cameron et al., 2013)

enhanceable

(Ferguson et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Ferguson et al., 2009)

enhanceable

(Al-Anzi and Wyman, 2009)

suppressible

(Müller et al., 2005)

enhanceable

(Ferguson et al., 2009)

enhanceable

(Vicente-Crespo et al., 2008)

suppressible

(Vicente-Crespo et al., 2008)

suppressible

(Wilk et al., 2004)

External Data

Subunit Structure (UniProtKB)

Interacts with bdl.

(UniProt, Q967D7 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010473

MIST (genetic) - An integrated Molecular Interaction Database

tutl

MIST (protein-protein) - An integrated Molecular Interaction Database

tutl

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010473

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-12

Cytogenetic map

Sequence location

2L:4,283,148..4,323,781 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

24E1-24E1

Limits computationally determined from genome sequence between P{lacW}ed^k01102 and P{PZ}tutl⁰¹⁰⁸⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

24E1-24E2

(determined by in situ hybridisation)

(Spradling et al., 1999)

24E1-24E2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-12

(FlyBase, 2016)

2-12.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

54850

y¹ v¹; P{TRiP.HMJ21587}attP40

44758

y¹ w^*; Mi{MIC}tutl^MI08144

63344

w¹¹¹⁸; PBac{IT.GAL4}tutl^0474-G4/CyO

10979

P{PZ}tutl⁰¹⁰⁸⁵ cn¹/CyO; ry⁵⁰⁶

30692

y¹ w^*; Mi{MIC}tutl^MI00290/CyO

10451

y¹ w^67c23; P{lacW}tutl^k14703/CyO

39651

y¹ w^*; Mi{PT-DV.1}tutl^MI00290-DV.1/SM6a

39653

y¹ w^*; Mi{PT-mCh.1}tutl^{MI00290-mCh.1}/SM6a

66824

y¹ w^*; Mi{Trojan-GAL4.1}tutl^{MI00290-TG4.1}/SM6a

204992

y¹ w^67c23; P{GSV6}tutl^GS13843/SM1

111106

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}tutl^k14703 P{neoFRT}40A/CyO y⁺

v108746

P{KK108880}VIE-260B

Genomic Clones (47)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (83)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT01550

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010473

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010473

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46015

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zhou et al., 2012, Sulkowski et al., 2011, Ferguson et al., 2009, Long et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: tutl l(2)01085 CG15427 CG15428

(Broadie, 2001.5.8)

Source for identity of: tutl l(2)01085 CG15426 CG15427

(FlyBase, 1996-)

Source for database merge of

Source for merge of: l(2)01085 CG15426

(Misra, 2000.8.25)

Source for merge of: tutl l(2)01085 CG15427

(Bodily et al., 2001)

Source for merge of: tutl l(2)24Df

(Dean, 2003.6.5)

Additional comments

Source for identity of tutl l(2)01085 CG15426 CG15427 was sequence comparison ( date:010521 ).

(FlyBase, 1996-)

Other Comments

A small subset of tutl-positive neurons are required for modulating directional change in response to gentle touch in larvae.

(Zhou et al., 2012)

tutl promotes midline attraction via a netrin-independent mechanism, ad not as part of the netrin signaling pathway.

(Al-Anzi and Wyman, 2009)

tutl promotes both motor and retinal axon branching and invasive behavior.

(Al-Anzi and Wyman, 2009)

tutl has a cell-autonomous role in specifying R7 axonal tiling (in parallel with Actβ).

(Ferguson et al., 2009)

tutl restricts dendrite branching in neurons with simple arbors and promotes self-avoidance in neurons with highly complex arbors.

(Long et al., 2009)

Mutations in tutl result in an abnormal response to tactile stimulation, the inability to regain an upright position from an inverted position, and the inability to fly in adulthood.

(Bodily et al., 2001)

Origin and Etymology

Discoverer

Etymology

The gene is named "turtle" after the mutant phenotype; mutants are unable to regain an upright position from an inverted position.

(Bodily et al., 2001)

Identification

External Crossreferences and Linkouts ( 90 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46015

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q967D7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010473

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010473

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46015/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010473

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010473

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010473

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15427

Flygut - An atlas of the Drosophila adult midgut

FBgn0010473

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010473

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46015

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008291

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG15427

MARRVEL_MODEL - MARRVEL (model organism gene)

46015

modMine - A data warehouse for the modENCODE project

FBgn0010473

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

10451-tutl[k14703]

DroID - A comprehensive database of gene and protein interactions.

FBgn0010473

DRSC - Results frm RNAi screens

FBgn0010473

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010473

FlyMine - An integrated database for Drosophila genomics

FBgn0010473

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

tutl

MIST (protein-protein) - An integrated Molecular Interaction Database

tutl

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG15426

CG15427

(Meadows, 2014.12.12, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

CG15428

CT35489

(Hynes and Zhao, 2000)

CT35490

(Hynes and Zhao, 2000)

Tutl

(DeAngelis et al., 2021, Kurmangaliyev et al., 2020, Weize Zhang et al., 2014, Ozkan et al., 2013)

jf4

(Dean, 2003.6.5, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)01085

(Misra, 2000.8.25, Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)24Df

l(2)jf4

mdcds_7441

(Chen and Oliver, 2014.8.15, FlyBase Genome Annotators, 2014)

Name Synonyms

Turtle

(Copf, 2015, Cameron et al., 2013, Ferguson et al., 2009, Long et al., 2009, Kwon et al., 2008)

lethal(2)24Df

turtle

(Cameron et al., 2013, Zhou et al., 2012, Al-Anzi and Wyman, 2009, Carbone et al., 2009, Mathew et al., 2009, Kurusu et al., 2008, Vicente-Crespo et al., 2008, Jordan et al., 2006, Bodily et al., 2001)

Secondary FlyBase IDs

FBgn0004699
FBgn0031593
FBgn0031594
FBgn0031595

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (98)

Report Sections