Dcp1, caspase-1, caspase
Please see the JBrowse view of Dmel\Dcp-1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
1.8 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
323 (aa); 22 <&> 13 (kD observed)
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dcp-1 using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\Dcp-1 in GBrowse 22-103
2-108.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Dcp-1 CG5370
Dcp-1 is a positive regulator of starvation-induced autophagic flux during oogenesis.
Loss of Dcp-1 promotes mitochondrial elongation.
Dcp-1 controls autophagic flux by a mechanism involving the regulation of the mitochondrial network and maintenance of ATP levels.
Ice is activated in wing discs after irradiation.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Dcp-1 cleaves caspase substrates and induces apoptosis in cultured cells.