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Gene Dmel\Dcp-1

General Information
Symbol	Dmel\Dcp-1	Species	D. melanogaster
Name	Death caspase-1	Annotation symbol	CG5370
Feature type	protein_coding_gene	FlyBase ID	FBgn0010501
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	Dcp1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	59E3-59E3	Sequence location	2R:19,438,838..19,441,079 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Death caspase-1 is referred to in FlyBase by the symbol Dmel\Dcp-1 (CG5370, FBgn0010501). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: apoptotic process; ovarian nurse cell to oocyte transport; cleavage of lamin; actin cytoskeleton organization; programmed cell death; neuron remodeling; embryo development; autophagic cell death; developmental programmed cell death; salivary gland cell autophagic cell death. 39 alleles are reported. The phenotypes of these alleles are annotated with: organ system; imaginal precursor; external compound sense organ; organ system subdivision; nervous system; embryonic/larval imaginal precursor; female germline cyst; cell projection; neuron projection; pigment cell; cell part; tracheal system; peripheral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, ICE, catalytic subunit p20, active site; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1637487_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dcp-1. Gene sequence location is 2R:19438838..19441079.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN26134 HFA04609 BKN45240 References Antosh et al., 2011, Aging 3(6): 576--583
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59E3-59E3   Limits computationally determined from genome sequence between P{lacW}l(2)s4830s4830&P{lacW}chrwk06908 and P{PZ}Dcp-102132
Experimentally Determined Cytological Location
Cytogenetic map Notes References 59F-59F     (Song, 1997.4.28) 59E3-59E4   (determined by in situ hybridisation)   (Spradling et al., 1999) 59E3-59E4   (determined by in situ hybridisation)   (Beaton, 1998.1.8) 59F2-59F3   (determined by in situ hybridisation)   (Beaton, 1997.12.27) 59F-59F   (determined by in situ hybridisation)   (Song et al., 1997) 59E3-59E4   59F2--3   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dcp-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dcp-1-RA FBtr0072062  NM_057626   1756   323
Additional Transcript Data & Comments
Reported size (kB)	1.8 (longest cDNA) (Song et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dcp-1-PA   FBpp0071971   35.9   323   7.83     NP_476974   AAF47027
Additional Polypeptide Data & Comments
Reported size (kDa)	323 (aa); 22 <&> 13 (kD observed) (Song et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) Peptidase C14, ICE, catalytic subunit p20, active site (IPR016129) MEROPS - An information resource for peptidases and the proteins that inhibit them • C14.016
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142298   AA391633   AA439387   AA820113   AA942565   AA949057   AA951845   AA979064   AE013599 AAF47027   AC005639   AF001464 AAB58237   AI512106   AI514588   AI514854   AI515667   AI516080   AI518396   AI518598   AI519531   AI542437   AI543955   AI543961   AW942294   BI162623   BI162624   BI164953   BI236960   BI358700   BI358701   BT010065 AAQ22534   CA804622   CO296800   CO324423   CZ470708   CZ470709   CZ471685   CZ471686   CZ481883   EC059258   EC059385   EC082118   EC217798   EC223779   EC228198   EC231246   EC233081   EC236288   G00735   GH792426   GH812833   GH881671   GH901287   GH907769   GH911471   GH936795
UniProtKB/Swiss-Prot	O02002
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Song et al., 1997) embryonic stage 1 -- 5   organism | ubiquitous & uniform   (Song et al., 1997) embryonic stage 5 -- 10   organism | ubiquitous   (Song et al., 1997) Comment:expressed in all cells embryonic stage 16 -- 17   embryonic/larval hindgut   (Song et al., 1997) gonad   (Song et al., 1997) embryonic head   (Song et al., 1997) embryonic/larval central nervous system | restricted   (Song et al., 1997) Comment:cells along midline
Additional Descriptive Data
	The Dcp-1 transcript is uniformly distributed in early and mid stage embryos. Dcp-1 expression becomes more restricted in late embryogenesis, with strong staining in parts of the central nervous system, the gut, gonads and the head. (Song et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010501    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010501 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010501 expression level Developmental Stage   Expression Level embryo 00-02hr    4323 embryo 02-04hr    9283 embryo 04-06hr    10675 embryo 06-08hr    7441 embryo 08-10hr    5630 embryo 10-12hr    3366 embryo 12-14hr    2403 embryo 14-16hr    2728 embryo 16-18hr    2144 embryo 18-20hr    1314 embryo 20-22hr    2454 embryo 22-24hr    2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new    1468 white prepupae 12hr    2938 white prepupae 24hr    3167 pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day    2361 adult female 05day    2676 adult female 30day    2881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4323) embryo 02-04hr  (9283) embryo 04-06hr  (10675) embryo 06-08hr  (7441) embryo 08-10hr  (5630) embryo 10-12hr  (3366) embryo 12-14hr  (2403) embryo 14-16hr  (2728) embryo 16-18hr  (2144) embryo 18-20hr  (1314) embryo 20-22hr  (2454) embryo 22-24hr  (2338) larva L1  (584) larva L2  (522) larva L3 12hr old  (450) larva L3 puffstage 1-2  (850) larva L3 puffstage 3-6  (909) larva L3 puffstage 7-9  (1293) white prepupae new  (1468) white prepupae 12hr  (2938) white prepupae 24hr  (3167) pupae 2d postWPP  (1397) pupae 3d postWPP  (417) pupae 4d postWPP  (729) adult male 01day  (427) adult male 05day  (407) adult male 30day  (473) adult female 01day  (2361) adult female 05day  (2676) adult female 30day  (2881) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4323) embryo 02-04hr  (9283) embryo 04-06hr  (10675) embryo 06-08hr  (7441) embryo 08-10hr  (5630) embryo 10-12hr  (3366) embryo 12-14hr  (2403) embryo 14-16hr  (2728) embryo 16-18hr  (2144) embryo 18-20hr    1314 embryo 20-22hr  (2454) embryo 22-24hr  (2338) larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new  1468 white prepupae 12hr  (2938) white prepupae 24hr  (3167) pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day  (2361) adult female 05day  (2676) adult female 30day  (2881) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4323 embryo 02-04hr    9283 embryo 04-06hr  10675 embryo 06-08hr    7441 embryo 08-10hr    5630 embryo 10-12hr    3366 embryo 12-14hr    2403 embryo 14-16hr    2728 embryo 16-18hr    2144 embryo 18-20hr    1314 embryo 20-22hr    2454 embryo 22-24hr    2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new    1468 white prepupae 12hr    2938 white prepupae 24hr    3167 pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day    2361 adult female 05day    2676 adult female 30day    2881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4323 embryo 02-04hr    9283 embryo 04-06hr    10675 embryo 06-08hr    7441 embryo 08-10hr    5630 embryo 10-12hr    3366 embryo 12-14hr    2403 embryo 14-16hr    2728 embryo 16-18hr    2144 embryo 18-20hr    1314 embryo 20-22hr    2454 embryo 22-24hr    2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new    1468 white prepupae 12hr    2938 white prepupae 24hr    3167 pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day    2361 adult female 05day    2676 adult female 30day    2881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010501 expression level Developmental Stage   Expression Level embryo 00-02hr    4323 embryo 02-04hr    9283 embryo 04-06hr    10675 embryo 06-08hr    7441 embryo 08-10hr    5630 embryo 10-12hr    3366 embryo 12-14hr    2403 embryo 14-16hr    2728 embryo 16-18hr    2144 embryo 18-20hr    1314 embryo 20-22hr    2454 embryo 22-24hr    2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new    1468 white prepupae 12hr    2938 white prepupae 24hr    3167 pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day    2361 adult female 05day    2676 adult female 30day    2881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4323) embryo 02-04hr  (9283) embryo 04-06hr  (10675) embryo 06-08hr  (7441) embryo 08-10hr  (5630) embryo 10-12hr  (3366) embryo 12-14hr  (2403) embryo 14-16hr  (2728) embryo 16-18hr  (2144) embryo 18-20hr  (1314) embryo 20-22hr  (2454) embryo 22-24hr  (2338) larva L1  (584) larva L2  (522) larva L3 12hr old  (450) larva L3 puffstage 1-2  (850) larva L3 puffstage 3-6  (909) larva L3 puffstage 7-9  (1293) white prepupae new  (1468) white prepupae 12hr  (2938) white prepupae 24hr  (3167) pupae 2d postWPP  (1397) pupae 3d postWPP  (417) pupae 4d postWPP  (729) adult male 01day  (427) adult male 05day  (407) adult male 30day  (473) adult female 01day  (2361) adult female 05day  (2676) adult female 30day  (2881) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4323) embryo 02-04hr  (9283) embryo 04-06hr  (10675) embryo 06-08hr  (7441) embryo 08-10hr  (5630) embryo 10-12hr  (3366) embryo 12-14hr  2403 embryo 14-16hr  (2728) embryo 16-18hr  2144 embryo 18-20hr    1314 embryo 20-22hr  2454 embryo 22-24hr  2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new  1468 white prepupae 12hr  (2938) white prepupae 24hr  (3167) pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day  2361 adult female 05day  (2676) adult female 30day  (2881) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4323 embryo 02-04hr    9283 embryo 04-06hr  10675 embryo 06-08hr    7441 embryo 08-10hr    5630 embryo 10-12hr    3366 embryo 12-14hr    2403 embryo 14-16hr    2728 embryo 16-18hr    2144 embryo 18-20hr    1314 embryo 20-22hr    2454 embryo 22-24hr    2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new    1468 white prepupae 12hr    2938 white prepupae 24hr    3167 pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day    2361 adult female 05day    2676 adult female 30day    2881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4323 embryo 02-04hr    9283 embryo 04-06hr    10675 embryo 06-08hr    7441 embryo 08-10hr    5630 embryo 10-12hr    3366 embryo 12-14hr    2403 embryo 14-16hr    2728 embryo 16-18hr    2144 embryo 18-20hr    1314 embryo 20-22hr    2454 embryo 22-24hr    2338 larva L1    584 larva L2    522 larva L3 12hr old    450 larva L3 puffstage 1-2    850 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    1293 white prepupae new    1468 white prepupae 12hr    2938 white prepupae 24hr    3167 pupae 2d postWPP    1397 pupae 3d postWPP    417 pupae 4d postWPP    729 adult male 01day    427 adult male 05day    407 adult male 30day    473 adult female 01day    2361 adult female 05day    2676 adult female 30day    2881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010501    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010501 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010501 expression level Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010501 expression level Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.275 Larval Midgut    168.8 Larval Hindgut    82.8 Larval Malpighian Tubules no informative data Larval Fat Body    19.7 Larval Salivary Gland    16.7 Larval Trachea    26.025 Larval Carcass    27.375 Adult Head    21.8 Adult Eye    15.525 Adult Brain    49.6 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    4.9 Adult Midgut    152.6 Adult Hindgut    41.3 Adult Malpighian Tubules no informative data Adult Fat Body    16.6 Adult Salivary Gland    6.8 Adult Heart    15.5 Adult VirginFemale Spermatheca    17.4 Adult InseminatedFemale Spermatheca    18.9 Adult Ovary    231.3 Adult Testis    22.1 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21.8   NA  Eye    15.525   NA  Brain    49.6   150.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    44.1   NA  Crop    4.9   168.8  Midgut    152.6   82.8  Hindgut    41.3   no informative data  Malpighian Tubules    no informative data   19.7  Fat Body    16.6   16.7  Salivary Gland    6.8   NA  Heart    15.5   26.025  Trachea    NA   NA  VirginFemale Spermatheca    17.4   NA  InseminatedFemale Spermatheca    18.9   NA  Ovary    231.3   NA  Testis    22.1   NA  Male Accessory Gland    5.4   27.375  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010501 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5370-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Dcp-1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect Dcp-101862 Dcp-102132 lethal | larval stage Dcp-101862 Dcp-102132 lethal | larval stage | recessive Dcp-101862 Dcp-102132 Dcp-1K2 lethal | pupal stage Dcp-1ΔN.GMR lethal | recessive Dcp-102121 Dcp-102132 Dcp-108859 Dcp-1k05606 Dcp-1k14408 semi-lethal Dcp-102132 viable, with Scer\GAL4pnr-MD237 Dcp-1GD10729 Dcp-1GD16194 Sterility Allele sterile, with Scer\GAL4nos.UTR.T:Hsim\VP16 Dcp-1ΔN.Scer\UAS.P\T Other Phenotypes Allele cell death defective Dcp-1Prev1 cell death defective, with Scer\GAL4Crz.504 Dcp-1miRNA.Scer\UAS decreased cell death Dcp-1dsRNA.cKa Dcp-1Prev1 eye color defective Dcp-1ΔN.GMR increased cell death Dcp-1A34G.Δ1-323.T:SV5\V5 increased cell death, with Scer\GAL4ninaE.PT Dcp-1Scer\UAS.cPa melanotic mass phenotype | recessive Dcp-101862 Dcp-102132 visible Dcp-1fl.GMR Dcp-1Prev1 Dcp-1ΔN.GMR Phenotype manifest in Allele actin filament & nurse cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 Dcp-1ΔN.Scer\UAS.P\T chaeta | supernumerary Dcp-1Prev1 dendrite Dcp-1Prev1 egg chamber, with Scer\GAL4nos.UTR.T:Hsim\VP16 Dcp-1ΔN.Scer\UAS.P\T egg chamber | conditional Dcp-1Prev1 embryonic/larval digestive system Dcp-102132 Dcp-1k05606 embryonic/larval digestive system (with Df(2R)or-BR6) Dcp-1k05606 eye Dcp-1ΔN.GMR Dcp-1GMR.PS Dcp-1N.GMR Dcp-1fl.GMR eye disc Dcp-1Prev1 gonad Dcp-101862 Dcp-102132 imaginal disc Dcp-101862 Dcp-102132 melanotic mass Dcp-102132 Dcp-1k05606 melanotic mass (with Df(2R)or-BR6) Dcp-1k05606 neuron Dcp-1Prev1 neuron, with Scer\GAL4Crz.504 Dcp-1miRNA.Scer\UAS nurse cell | maternal effect Dcp-101862 Dcp-102132 outer photoreceptor cell, with Scer\GAL4ninaE.PT Dcp-1Scer\UAS.cPa pigment cell Dcp-1ΔN.GMR Dcp-1fl.GMR trachea Dcp-101862 Dcp-102132
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of Dcp-1 Class Mutagen Stocks Known lesion Dcp-1k05606 P-element activity 3 Yes Dcp-102132 P-element activity 2 Yes Dcp-1c06469 piggyBac transposase 1 -- Dcp-101862 P-element activity 0 Yes Dcp-102121 P-element activity 0 Yes Dcp-108859 P-element activity 0 Yes Dcp-1CB03160 P-element activity 0 Yes Dcp-1d00593 P-element activity 0 -- Dcp-1e04129 piggyBac transposase 0 -- Dcp-1k14408 P-element activity 0 Yes Dcp-1K2 ethyl methanesulfonate 0 -- Dcp-1levy2 Delta2-3 0 Yes Dcp-1levy3 Delta2-3 0 Yes Dcp-1levy4 Delta2-3 0 Yes Dcp-1mgb48 P-element activity gene conversion 0 Yes Dcp-1O3 ethyl methanesulfonate 0 -- Dcp-1Prev1 Delta2-3 0 Yes Dcp-1S2 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dcp-1 Class Mutagen Stocks Known lesion Dcp-1GD10729 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dcp-1GD16194 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcp-1HM05120 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcp-1KK106134 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcp-1a.cIa in vitro construct - RNAi in vitro construct 0 Yes Dcp-1A34G.Δ1-323.T:SV5\V5 in vitro construct - deletion in vitro construct - site directed mutagenesis 0 Yes Dcp-1Act5C.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dcp-1cIa in vitro construct - RNAi in vitro construct 0 Yes Dcp-1dsRNA.152-937 in vitro construct - RNAi 0 Yes Dcp-1dsRNA.cKa in vitro construct - RNAi 0 Yes Dcp-1dsRNA.Scer\UAS.cLa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Dcp-1fl.GMR in vitro construct - regulatory fusion 0 Yes Dcp-1GMR.PS in vitro construct - regulatory fusion 0 Yes Dcp-1miRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Dcp-1N.GMR in vitro construct - regulatory fusion 0 Yes Dcp-1Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes Dcp-1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dcp-1t4.4 in vitro construct - genomic fragment 0 Yes Dcp-1Δ1-33.MtnA in vitro construct - regulatory fusion 0 Yes Dcp-1ΔN.GMR in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes Dcp-1ΔN.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)bw5 (Song et al., 1997) Df(2R)bwVDe2LPxKR (Spradling et al., 1999, BDGP Project Members, 1994-1999, Beaton, 1997.12.27) Df(2R)bw-DRa (Song et al., 1997) Df(2R)bw-S46 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Exel7180 (Ryder, 2004.4.26)
Not disrupted in	In(2LR)ltG10LBR27R (Song et al., 1997)
Partially disrupted in	Df(2R)levy2 (Liu et al., 2007) Df(2R)levy3 (Liu et al., 2007) Df(2R)levy4 (Liu et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10729} NA P{GD16194} NA P{KK106134} NA P{TRiP.HM05120} NA P{UAS-Dcp-1.P} NA P{UASp-Dcp-1.ΔN} NA characterization construct P{Dcp-1.t4.4} NA P{GMR-Dcp-1.N} NA P{GMR-Dcp-1.S} NA P{GMR-fl-Dcp-1} NA P{GMR-ΔN-Dcp-1} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Dcp-1k05606 No P{lacW}Dcp-1k14408 No P{lacW}l(2)SH0376SH0376 No P{PZ}Dcp-101862 No P{PZ}Dcp-102121 No P{PZ}Dcp-102132 No P{PZ}Dcp-108859 No miscellaneous insertions P{hsp26-pt-T}Dcp-1mgb48 NA P{PTT-GB}Dcp-1CB03160 NA PBac{PB}Dcp-1c06469 NA PBac{RB}Dcp-1e04129 NA insertion of mobile activating element P{XP}Dcp-1d00593 NA
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from direct assay (McCall et al., 1997) inferred from direct assay AND inferred from sequence or structural similarity (Song et al., 1997)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (McCall and Steller, 1998) apoptotic process inferred from direct assay (McCall et al., 1997, Song et al., 1997) inferred from mutant phenotype (McCall and Steller, 1998) autophagic cell death inferred from expression pattern (Gorski et al., 2003) cleavage of lamin inferred from mutant phenotype (McCall and Steller, 1998) developmental programmed cell death inferred from mutant phenotype (Kondo et al., 2006) embryo development inferred from mutant phenotype (Song et al., 1997) neuron remodeling inferred from mutant phenotype (Schoenmann et al., 2010) ovarian nurse cell to oocyte transport inferred from mutant phenotype (McCall and Steller, 1998) programmed cell death inferred from direct assay (Lee et al., 2011) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity (Coates, 1999.11) non-traceable author statement (Meier et al., 2000, Swiss-Prot Project Members, 1998.2.1) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Bergmann et al., 2003, Abrams, 1999, Tittel and Steller, 2000)
Biological Process
CV term Evidence References
actin filament organization traceable author statement (Buszczak and Cooley, 2000) apoptotic process non-traceable author statement (Swiss-Prot Project Members, 1998.2.1) traceable author statement (Bergmann et al., 2003) cytoplasmic transport, nurse cell to oocyte traceable author statement (Buszczak and Cooley, 2000, Kumar and Doumanis, 2000) multicellular organismal development traceable author statement (Abrams, 1999) nurse cell apoptosis traceable author statement (Buszczak and Cooley, 2000, Richardson and Kumar, 2002) ovarian nurse cell to oocyte transport traceable author statement (Abrams, 1999) proteolysis traceable author statement (Bergmann et al., 2003)
Cellular Component
CV term Evidence References
caspase complex non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dcp-1 allele Gene References Dcp-1a.cIa rpr (Igaki et al., 2002) Dcp-1Act5C.T:SV5\V5 th (Tenev et al., 2005) Dcp-1cIa rpr (Igaki et al., 2002) Dcp-1fl.GMR grim (Song et al., 2000) rpr (Song et al., 2000) W (Song et al., 2000) Dcp-1GMR.PS Ark (Zhou et al., 1999) rpr (Zhou et al., 1999) Dcp-1N.GMR Ark (Zhou et al., 1999) Dcp-1ΔN.Scer\UAS.P\T th (Peterson et al., 2003) unspecified Ice (Muro et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63329 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010501 DroID - A comprehensive database of gene and protein interactions. • FBgn0010501 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37729
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13064 Dere\GG22866 Dgri\GH21208 Dmoj\GI20496 Dper\GL16870 Dpse\GA18828 Dsec\GM16025 Dsim\GD11774 Dvir\GJ22346 Dwil\GK23280 Dyak\GE14302
Curated drosophilid orthologs	Dpse\GA18828
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • ENSBTAP00000008706 Bos taurus (bovine) CN19004 Caenorhabditis brenneri (small nematode) CN20874 Caenorhabditis brenneri (small nematode) ENSCAFP00000016420 Canis familiaris (dog) ENSCSAVP00000004868 Ciona savignyi (sedentary tunicate) ENSCSAVP00000004880 Ciona savignyi (sedentary tunicate) 139929 Capitella spl (polychaete worm) ENSGACP00000008661 Gymnopilus aculeatus (mushroom) 157123 Hypsipyla robusta (cedar shoot borer) 106792 Lottia gigantea (owl limpet) ENSMMUP00000001627 Macaca mulatta (rhesus monkey) ENSMUSP00000026062 Mus musculus (house mouse) ENSRNOP00000022693 Rattus norvegicus (norway rat) Smp_172010 Schistosoma mansoni (trematode parasite) ENSTNIP00000009934 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000022078 Tetraodon nigroviridis (green spotted pufferfish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14744 NV11553 LH17480 ISCW013172 FBgn0241035 FBgn0231917 FBgn0225242 FBgn0213939 FBgn0213938 FBgn0213937 FBgn0211181 FBgn0209459 FBgn0206694 FBgn0192901 FBgn0183513 FBgn0170941 FBgn0167759 JGI_V11_309162 JGI_V11_307426 FBgn0080582 FBgn0078828 FBgn0161105 FBgn0154474 FBgn0144772 FBgn0143232 FBgn0019972 FBgn0128670 FBgn0127420 FBgn0127409 FBgn0115023 FBgn0095684 FBgn0090097 CPIJ000671 CPIJ009057 BGIBMGA006946 ACYPI003462 ACYPI001931 GB19042 CASPS7 CASPS5 PB24677 PHUM221390 GLEAN_03841
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	28909 y1 v1; P{TRiP.HM05120}attP2 11179 cn1 P{PZ}Dcp-102132 pita02132/CyO; ry506 10390 y1 w67c23; P{lacW}Dcp-1k05606 pitak05606/CyO
Harvard	- PBac{PB}Dcp-1c06469
Kyoto	108865 cn1 P{PZ}Dcp-102132/CyO; ry506 108854 y1 w67c23; P{lacW}Dcp-1k05606/CyO 111082 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}Dcp-1k05606CyO y+ /CyO y+
VDRC	v107560 P{KK106134}VIE-260B v34328 w1118; P{GD10729}v34328 v34330 w1118; P{GD10729}v34330 v46616 w1118; P{GD16194}v46616/TM3
Genomic Clones ( 2 )
	BACR25I01 BACR48M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 43 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13945
Other clones	DPiM_LD13945
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM31382 GM31384 LD10653 LD22727 LD26865 LD27807 LD32577 LD33324 LD37891 LD38207 LD39155 LD41279 LD41831 LD43823 LD45656 LD45663 LD46105 LD47572 RE04732 RE33108 SD08765
Other clones	16531 65988 81722 275552 CK01.28A.E7 CK01.104D.F11 CK01.104D.G11 CK01.108C.E8 CK01706 EK193633 EK215204 ESG0114c.B21_A08 RE01891 RP003042551 RP003124883 RP003127355 RP003183657 RP003452248 RP003513611 RP003550904
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010501 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37729
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dcp-1 CG5370 (Zhang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) th promotes cell survival by blocking the activity of the Dcp-1 gene product. (Wang et al., 1999) Loss of Dcp-1 produces nurse cells are defective in cytoskeletal reorganisation and nuclear breakdown so fail to transfer their contents to the developing oocytes. This suggests that the cytoskeletal and nuclear events in the nurse cells make use of the machinery normally associated with apoptosis and that apoptosis of the nurse cells is a necessary event for oocyte development. (McCall and Steller, 1998) Dcp-1 cleaves caspase substrates and induces apoptosis in cultured cells. (McCall et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057626 RefSeq (Proteins) • NP_476974 DDBJ / EMBL / GenBank • AA439387 AAB58237 AAF47027 AAQ22534 AC005639 AF001464 AW942294 BT010065 CZ470708 CZ470709 CZ471685 CZ471686 CZ481883 G00735 Entrez Gene - A searchable database of RefSeq genes. • 37729 UniProtKB/Swiss-Prot • O02002
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) Peptidase C14, ICE, catalytic subunit p20, active site (IPR016129) MEROPS - An information resource for peptidases and the proteins that inhibit them • C14.016
Linkouts
	BioGRID - A database of protein and genetic interactions • 63329 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010501 DroID - A comprehensive database of gene and protein interactions. • FBgn0010501 DRSC - Results from RNAi screens. • FBgn0010501 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010501 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5370-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010501 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37729 InParanoid A subset of ortholog calls from InParanoid. • ENSBTAP00000008706 Bos taurus (bovine) CN19004 Caenorhabditis brenneri (small nematode) CN20874 Caenorhabditis brenneri (small nematode) ENSCAFP00000016420 Canis familiaris (dog) ENSCSAVP00000004868 Ciona savignyi (sedentary tunicate) ENSCSAVP00000004880 Ciona savignyi (sedentary tunicate) 139929 Capitella spl (polychaete worm) ENSGACP00000008661 Gymnopilus aculeatus (mushroom) 157123 Hypsipyla robusta (cedar shoot borer) 106792 Lottia gigantea (owl limpet) ENSMMUP00000001627 Macaca mulatta (rhesus monkey) ENSMUSP00000026062 Mus musculus (house mouse) ENSRNOP00000022693 Rattus norvegicus (norway rat) Smp_172010 Schistosoma mansoni (trematode parasite) ENSTNIP00000009934 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000022078 Tetraodon nigroviridis (green spotted pufferfish) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/casps1-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37729 modMine - Data generated by the modENCODE project. • FBgn0010501 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14744 NV11553 LH17480 ISCW013172 FBgn0241035 FBgn0231917 FBgn0225242 FBgn0213939 FBgn0213938 FBgn0213937 FBgn0211181 FBgn0209459 FBgn0206694 FBgn0192901 FBgn0183513 FBgn0170941 FBgn0167759 JGI_V11_309162 JGI_V11_307426 FBgn0080582 FBgn0078828 FBgn0161105 FBgn0154474 FBgn0144772 FBgn0143232 FBgn0019972 FBgn0128670 FBgn0127420 FBgn0127409 FBgn0115023 FBgn0095684 FBgn0090097 CPIJ000671 CPIJ009057 BGIBMGA006946 ACYPI003462 ACYPI001931 GB19042 CASPS7 CASPS5 PB24677 PHUM221390 GLEAN_03841
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	ccp1 (Amarneh et al., 2009) CG5370 (Li et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009) dcp-1 (Baum et al., 2007, Zheng et al., 2005, Kilpatrick et al., 2005, Kondo et al., 2005, Baum et al., 2005, Cakouros et al., 2004, Bergmann et al., 2003, Peterson et al., 2004, Peterson et al., 2003, Barkett et al., 2003, McCall et al., 2003, Richardson and Kumar, 2002, Peterson et al., 2002, Laundrie and McCall, 2002, Kumar and Doumanis, 2000, Buszczak et al., 2001, McCall et al., 2001, Buszczak and Cooley, 2000, Vernooy et al., 2000, Zhou et al., 1999, Varkey et al., 1999, Bergmann et al., 1999, Hoffmann and Reichhart, 1997, McCall and Steller, 1997, Xu et al., 2006, McCall et al., 2007, Moon et al., 2005, Denton et al., 2008, Kondo et al., 2006, Mendes et al., 2006, Fan and Bergmann, 2008, Leulier et al., 2006, Primrose et al., 2007, Mendes et al., 2009, Denton et al., 2009, Mallik and Lakhotia, 2009, Fan and Bergmann, 2010, Schoenmann et al., 2010) Dcp-1 (Dworkin and Gibson., 2006, Minakhina and Steward, 2006, Fan and Bergmann, 2007, Muro et al., 2006, Jordan et al., 2005, Buszczak et al., 2007, Kuranaga and Miura, 2007, Baehrecke, 2006, Liu et al., 2007, Kornbluth and White, 2005, Somma et al., 2008, Hou et al., 2008, Peng et al., 2007, Li et al., 2009, Copeland et al., 2007, Kim et al., 2010, Lee et al., 2011, Schoenmann et al., 2010) DCP-1 (Tenev et al., 2005, Olson et al., 2003, Jabbour et al., 2002, Igaki et al., 2002, Srinivasula et al., 2002, Yu et al., 2001, Harvey et al., 2001, Matova and Cooley, 2001, Meier et al., 2000, Huh et al., 2001, Baehrecke, 2000, Hawkins et al., 2000, Song et al., 2000, Gaumer et al., 2000, Song, 1997.4.28, Dorstyn et al., 1999, Miller, 1999, Hawkins et al., 1999, Bergmann et al., 1998, Meier and Evan, 1998, Green and Kroemer, 1998, Cory and Adams, 1998, McCall and Steller, 1998, Fraser et al., 1997, Jallepalli and Bogyo, 1997, Shin and Yoo, 2007, Kim and Yoo, 2007, Shin and Yoo, 2008, Creagh et al., 2009, Tenev et al., 2007, Khan et al., 2008) Dcp1 (Danial and Korsmeyer, 2004, Moskalev, 2004, Di Fruscio et al., 2003, Yu et al., 2002) dcp1 (Moskalev, 2001, Foglietti et al., 2006, Xu et al., 2006) DCP1 (Jones et al., 2000, Kessler and Müller, 2009) l(2)01862   l(2)02132
Name Synonym	caspase (Bose et al., 1998, Kondo et al., 1997) caspase-1 (White et al., 1999, Song, 1997.4.28) caspase 1 (Khan et al., 2008) Death caspase-1 (Tsuda et al., 2006) death caspase-1 (Hou et al., 2008, Mendes et al., 2009)
Secondary FlyBase IDs
	FBgn0010509
References ( 151 )
Generate a list of	All references relating to this gene ( 151 )
List References by type	Research paper  ( 69 ) Supplementary material  ( 7 ) Review  ( 28 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 25 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 3 ) Curated genome annotation  ( 2 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 6 )
	Antosh et al., 2011, Aging 3(6): 576--583 New comparative genomics approach reveals a conserved health span signature across species. [FBrf0216594] Lee et al., 2011, J. Comp. Neurol. 519(1): 34--48 Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. [FBrf0212368] Tanner et al., 2011, Development 138(2): 327--338 Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. [FBrf0212552] Fan and Bergmann, 2010, Cell Death Differ. 17(3): 534--539 The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. [FBrf0209949] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Schoenmann et al., 2010, J. Neurosci. 30(18): 6375--6386 Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. [FBrf0210748] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...