FlyBase Gene Report: Dmel\Dcp-1

General Information

Symbol

Dmel\Dcp-1

Species

D. melanogaster

Name

Death caspase-1

Annotation Symbol

CG5370

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010501

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Snapshot

Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dcp1, caspase-1, caspase

Key Links

Genomic Location

Cytogenetic map

59E3-59E3

Sequence location

2R:23,551,313..23,553,547 [+]

Recombination map

2-103

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

CASPASES

Protein Family (UniProt)

Belongs to the peptidase C14A family. (O02002)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

BIR domain binding; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; protein binding

Predictions / Assertions

cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process

Summaries

Gene Group (FlyBase)

CASPASES -: Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. (Adapted from FBrf0215539).

Protein Function (UniProtKB)

Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.

(UniProt, O02002)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Dcp-1 or the JBrowse view of Dmel\Dcp-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dcp-1-RA

FBtr0072062

NM_057626

1749

323

Additional Transcript Data and Comments

Reported size (kB)

1.8 (longest cDNA)

(Song et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Dcp-1-PA

FBpp0071971

35.9

323

7.83

NP_476974

AAF47027

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

323 (aa); 22 <&> 13 (kD observed)

(Song et al., 1997)

Comments

External Data

Subunit Structure (UniProtKB)

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.

(UniProt, O02002)

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

C14.016

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dcp-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dcp-1_1

Linkouts

Gene Ontology (26 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

BIR domain binding

inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635

(Leulier et al., 2006)

cysteine-type endopeptidase activity

inferred from direct assay

(Wang et al., 1999, Song et al., 1997)

cysteine-type endopeptidase activity involved in execution phase of apoptosis

inferred from mutant phenotype

(McCall and Steller, 1998)

protein binding

inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635

(Wang et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

cysteine-type endopeptidase activity

traceable author statement

(Bergmann et al., 2003, Richardson and Kumar, 2002, Kumar and Doumanis, 2000, Tittel and Steller, 2000, Abrams, 1999)

inferred from sequence or structural similarity

(Song et al., 1997)

cysteine-type endopeptidase activity involved in apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (15 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

apoptotic process

inferred from direct assay

(Song et al., 1997)

cellular response to starvation

inferred from mutant phenotype

(Hou et al., 2008)

execution phase of apoptosis

inferred from mutant phenotype

(McCall and Steller, 1998)

negative regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Keller et al., 2011)

neuron remodeling

inferred from mutant phenotype

(Schoenmann et al., 2010)

nurse cell apoptotic process

inferred from mutant phenotype

(McCall and Steller, 1998)

inferred from genetic interaction with FLYBASE:Drice; FB:FBgn0019972

(Baum et al., 2007)

oogenesis

inferred from mutant phenotype

(DeVorkin et al., 2014, Hou et al., 2008)

positive regulation of autophagy

inferred from direct assay

(DeVorkin et al., 2014, Kim et al., 2010)

positive regulation of macroautophagy

inferred from mutant phenotype

(Hou et al., 2008)

programmed cell death

inferred from direct assay

(Lee et al., 2011)

programmed cell death involved in cell development

inferred from mutant phenotype

(Kondo et al., 2006)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(assigned by GO_Central )

(Gaudet et al., 2011)

cytoplasmic transport, nurse cell to oocyte

traceable author statement

(Kumar and Doumanis, 2000)

multicellular organism development

traceable author statement

(Abrams, 1999)

nurse cell apoptotic process

traceable author statement

(Richardson and Kumar, 2002)

ovarian nurse cell to oocyte transport

traceable author statement

(Abrams, 1999)

proteolysis

inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR011600, InterPro:IPR016129

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

messenger ribonucleoprotein complex

inferred from direct assay

(assigned by UniProt )

(Hillebrand et al., 2010, Barbee et al., 2006)

mitochondrion

inferred from direct assay

(DeVorkin et al., 2014)

neuronal cell body

inferred from direct assay

(assigned by UniProt )

(Hillebrand et al., 2010)

neuronal ribonucleoprotein granule

inferred from direct assay

(assigned by UniProt )

(Hillebrand et al., 2010, Barbee et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(assigned by GO_Central )

(Gaudet et al., 2011)

cytosol

inferred from sequence or structural similarity with HGNC:1508

(FlyBase Curators, 2008--)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Song et al., 1997)

embryonic stage 1 -- 5

organism | ubiquitous | uniform

(Song et al., 1997)

embryonic stage 5 -- 10

organism | ubiquitous

Comment: expressed in all cells

(Song et al., 1997)

embryonic stage 16 -- 17

embryonic/larval hindgut

(Song et al., 1997)

gonad

(Song et al., 1997)

embryonic head

(Song et al., 1997)

embryonic/larval central nervous system | restricted

Comment: cells along midline

(Song et al., 1997)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

Additional Descriptive Data

The Dcp-1 transcript is uniformly distributed in early and mid stage embryos. Dcp-1 expression becomes more restricted in late embryogenesis, with strong staining in parts of the central nervous system, the gut, gonads and the head.

(Song et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

messenger ribonucleoprotein complex

inferred from direct assay

(assigned by UniProt )

(Hillebrand et al., 2010, Barbee et al., 2006)

mitochondrion

inferred from direct assay

(DeVorkin et al., 2014)

neuronal cell body

inferred from direct assay

(assigned by UniProt )

(Hillebrand et al., 2010)

neuronal ribonucleoprotein granule

inferred from direct assay

(assigned by UniProt )

(Hillebrand et al., 2010, Barbee et al., 2006)

Expression Deduced from Reporters

Reporter: P{PZ}Dcp-1⁰²¹³²

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

imaginal disc

(Meister and Braun, 1995.10)

embryonic/larval brain

(Meister and Braun, 1995.10)

embryonic/larval fat body

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dcp-1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dcp-1

View exonic expression by tissue for Dmel\Dcp-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010501

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010501

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5370-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5370

Flygut - An atlas of the Drosophila adult midgut

FBgn0010501

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dcp-1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dcp-1

Transgenic constructs containing regulatory region of Dcp-1

Deletions and Duplications ( 13 )

Disrupted in

Df(2R)bw5

(Song et al., 1997)

Df(2R)bw^VDe2LPx^KR

(Spradling et al., 1999, Beaton, 1997.12.27, BDGP Project Members, 1994-1999)

Df(2R)bw-DRa

(Song et al., 1997)

Df(2R)bw-S46

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Exel7180

(Ryder, 2004.4.26)

Not disrupted in

In(2LR)lt^G10LBR27^R

(Song et al., 1997)

Partially disrupted in

Df(2R)ahd2

(Sage et al., 2005)

Df(2R)ahf6

(Sage et al., 2005)

Df(2R)csa3

(Sage et al., 2005)

Df(2R)csa7

(Sage et al., 2005)

Df(2R)levy²

(Liu et al., 2007)

Df(2R)levy³

(Liu et al., 2007)

Df(2R)levy⁴

(Liu et al., 2007)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage

Dcp-1^ΔN.GMR

partially lethal, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dcp-1^GD10729

viable, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Dcp-1^GD10729

Sterility

Allele

sterile, with Scer\GAL4^VP16.nos.UTR

Dcp-1^ΔN.UASp

Other Phenotypes

Allele

cell death defective

Dcp-1^Prev1

cell death defective, with Scer\GAL4^Crz.504

Dcp-1^miRNA.UAS

cell death defective | adult stage | nutrition conditional

cell death defective | P-stage | recessive

Dcp-1^Prev1

decreased cell death

Dcp-1^Prev1

decreased cell death | adult stage | nutrition conditional

Dcp-1^Prev1

eye color defective

Dcp-1^ΔN.GMR

eye color defective, with Scer\GAL4^GMR.PFa

Dcp-1^UAS.cKa

increased cell death

Dcp-1^Prev1

increased cell death, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

increased cell death, with Scer\GAL4^ninaE.PT

Dcp-1^UAS.cPa

increased cell death | adult stage, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR

Dcp-1^UASp.cHa

increased cell death | adult stage, with Scer\GAL4^VP16.nos.UTR

Dcp-1^ΔN.UASp

neuroanatomy defective, with Scer\GAL4^elav-C155

Dcp-1^UAS.cKa

neurophysiology defective, with Scer\GAL4^elav-C155

Dcp-1^UAS.cKa

short lived, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

some die during pupal stage

Dcp-1^ΔN.GMR

starvation stress response defective

Dcp-1⁰²¹³²

starvation stress response defective, with Scer\GAL4^da.G32

Dcp-1^GD10729

visible

visible, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

visible | adult stage, with Scer\GAL4^GMR.PFa

Dcp-1^UAS.cKa

Phenotype manifest in

Allele

actin filament & nurse cell, with Scer\GAL4^VP16.nos.UTR

Dcp-1^ΔN.UASp

adult optic lobe | P-stage

Dcp-1^Prev1

autophagosome

Dcp-1⁰²¹³²

autophagosome, with Scer\GAL4^da.G32

Dcp-1^GD10729

chaeta | supernumerary

Dcp-1^Prev1

dendrite

Dcp-1^Prev1

egg chamber

Dcp-1^UASp.cHa

egg chamber, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR

Dcp-1^UASp.cHa

egg chamber, with Scer\GAL4^VP16.nos.UTR

Dcp-1^ΔN.UASp

egg chamber | conditional

Dcp-1^Prev1

egg chamber | nutrition conditional

eye

eye, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

eye, with Scer\GAL4^GMR.PFa

Dcp-1^UAS.cKa

eye disc

Dcp-1^Prev1

female germline cyst | nutrition conditional

Dcp-1^Prev1

follicle cell

Dcp-1^UASp.cHa

follicle cell | nutrition conditional

germarium region 2 | nutrition conditional

Dcp-1^Prev1

male germline cell

Dcp-1^Prev1

mitochondrion | nutrition conditional

Dcp-1^Prev1

neuron

Dcp-1^Prev1

neuron, with Scer\GAL4^Crz.504

Dcp-1^miRNA.UAS

outer photoreceptor cell, with Scer\GAL4^ninaE.PT

Dcp-1^UAS.cPa

pigment cell

spermatogonial cyst

Dcp-1^Prev1

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CASP7

13 of 15

Yes

Hsap\CASP3

10 of 15

Hsap\CASP6

6 of 15

Yes

Hsap\CFLAR

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Hsap\CARD16

1 of 15

Yes

Hsap\CARD17

1 of 15

Yes

Hsap\CARD18

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\PTCD1

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Casp7

13 of 15

Yes

Mmus\Casp3

11 of 15

Mmus\Casp6

6 of 15

Yes

Mmus\Cflar

3 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (13)

Rnor\Casp3

11 of 13

Yes

Rnor\Casp7

8 of 13

Yes

Rnor\LOC103689977

4 of 13

Yes

Rnor\Casp6

3 of 13

Yes

Rnor\Cflar

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Casp12

1 of 13

Rnor\Pea15

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (10)

Xtro\casp3

10 of 12

Yes

Xtro\casp7

7 of 12

Yes

Xtro\casp6

3 of 12

Yes

Xtro\casp2

2 of 12

Xtro\casp9

2 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\pea15

1 of 12

Yes

Danio rerio (Zebrafish) (26)

Drer\casp3a

12 of 15

Yes

Drer\casp3b

12 of 15

Yes

Drer\casp7

8 of 15

Yes

Drer\LOC100331324

7 of 15

Yes

Drer\casp6

5 of 15

Yes

Drer\casp6l2

3 of 15

Yes

Drer\casp8l1

3 of 15

Drer\cflara

3 of 15

Yes

Drer\LOC798445

3 of 15

Drer\LOC101886133

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\si:ch211-195h23.3

2 of 15

Yes

Drer\si:dkey-103e21.5

2 of 15

Yes

Drer\zgc:194469

2 of 15

Yes

Drer\caspa

1 of 15

Drer\gbp3

1 of 15

Yes

Drer\pea15

1 of 15

Yes

Drer\zgc:171731

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\ced-3

8 of 15

Yes

Cele\csp-1

3 of 15

Cele\csp-2

3 of 15

Yes

Cele\csp-3

3 of 15

Yes

Cele\ZK795.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190AYN )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Dcp-1

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18828

Drosophila persimilis

Dper\GL16870

Drosophila willistoni

Dwil\GK23280

Drosophila virilis

Dvir\GJ22346

Drosophila mojavensis

Dmoj\GI20496

Drosophila grimshawi

Dgri\GH21208

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503R7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17012787

Musca domestica

House fly

Mdoa\17021485

Glossina morsitans

Tsetse fly

Gmor\GMOY005883

Glossina morsitans

Tsetse fly

Gmor\GMOY007347

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07925

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13466

Mayetiola destructor

Hessian fly

Mdes\Mdes002881

Aedes aegypti

Yellow fever mosquito

Aaeg\CASPS8

Anopheles darlingi

American malaria mosquito

Adar\ADAC006014

Anopheles darlingi

American malaria mosquito

Adar\ADAC004636

Anopheles gambiae

Malaria mosquito

Agam\CASPS7

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000671

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009056

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03JD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006946

Danaus plexippus

Monarch butterfly

Dple\DPOGS213029-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004700

Apis florea

Little honeybee

Aflo\4054857652

Apis mellifera

Western honey bee

Amel\LOC412235

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16697

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17823

Bombus terrestris

Buff-tailed bumblebee

Bter\15213364

Bombus terrestris

Buff-tailed bumblebee

Bter\15216186

Linepithema humile

Argentine ant

Lhum\LH17480

Linepithema humile

Argentine ant

Lhum\LH11162

Linepithema humile

Argentine ant

Lhum\LH11050

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002ec5

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001b1f

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001d5a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010240

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010089

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010095

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12329

Tribolium castaneum

Red flour beetle

Tcas\TC003841

Pediculus humanus

Human body louse

Phum\PHUM536790

Pediculus humanus

Human body louse

Phum\PHUM221390

Rhodnius prolixus

Kissing bug

Rpro\RPRC003946

Rhodnius prolixus

Kissing bug

Rpro\RPRC011129

Cimex lectularius

Bed bug

Clec\CLEC006064

Cimex lectularius

Bed bug

Clec\CLEC001510

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003462

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004566

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001931

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003094

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13497

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17676

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14304

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18362

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03G0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR010202

Strigamia maritima

European centipede

Smar\SMAR005942

Ixodes scapularis

Black-legged tick

Isca\ISCW013172

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82851.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82848.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g02850

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g08820

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_314077

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307426

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_314078

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_309162

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05YD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CspeN2b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L1a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L1b2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CspeN5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_023703gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CspeN2a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_001472gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007259gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe6L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L1b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L2b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe3/7L

Ciona intestinalis

Vase tunicate

Cint\LOC100185724

Ciona intestinalis

Vase tunicate

Cint\LOC100175572

Ciona intestinalis

Vase tunicate

Cint\LOC100177955

Ciona intestinalis

Vase tunicate

Cint\LOC100185209

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024334

Ciona intestinalis

Vase tunicate

Cint\LOC494382

Ciona intestinalis

Vase tunicate

Cint\LOC100178691

Ciona intestinalis

Vase tunicate

Cint\LOC100183628

Gallus gallus

Domestic chicken

Ggal\CASP3

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008346

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008240

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008305

Gallus gallus

Domestic chicken

Ggal\CASP6

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008355

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001366

Gallus gallus

Domestic chicken

Ggal\CASP2

Gallus gallus

Domestic chicken

Ggal\CASP7

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (6)

Gene Symbol

Score

Source

Alignment

9 of 10

5 of 10

4 of 10

3 of 10

3 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 15

10 of 15

6 of 15

CFLAR; CASP8 and FADD like apoptosis regulator

3 of 15

603599

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dcp-1 - Diap1

pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Leulier et al., 2006, Tenev et al., 2005)

Dcp-1 - Drice

enzymatic study, autoradiography, western blot

(Choutka et al., 2017, DeVorkin et al., 2014)

Dcp-1 - Hsp83

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Choutka et al., 2017)

Dcp-1 - sesB

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(DeVorkin et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dcp-1

suppressible

Acn

(Nandi et al., 2014)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

Dcp-1

suppressible

(Kim et al., 2010)

Dcp-1

suppressible

Dark

(Sinenko, 2017, Zhou et al., 1999)

Dcp-1

suppressible

Diap1

(Kim et al., 2010, Peterson et al., 2003)

Dcp-1

enhanceable

(Kim et al., 2010)

enhanceable

(Lee et al., 2011)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Song et al., 2000)

Dcp-1

enhanceable

hid

(Song et al., 2000)

Dcp-1

suppressible

lncRNA:Hsrω

(Mallik and Lakhotia, 2009)

Dcp-1

suppressible

ninaA

(Mendes et al., 2009)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Song et al., 2000, Zhou et al., 1999)

suppressible

(Kim et al., 2010)

suppressible

(DeVorkin et al., 2014)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Sinenko, 2017)

suppressible

(Kim et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acn

enhanceable

Dcp-1

(Nandi et al., 2014)

Ank2

suppressible

Dcp-1

(Keller et al., 2011)

Drice

enhanceable

Dcp-1

(Muro et al., 2006, Xu et al., 2006)

Drice|hid

suppressible

Dcp-1

(Leulier et al., 2006)

Drice|Diap1

suppressible

Damm|Dcp-1|Decay

(Leulier et al., 2006)

enhanceable

(Lee et al., 2011)

suppressible

(Leulier et al., 2006)

nos

suppressible

Dcp-1

(Bhogal et al., 2016)

rpr

enhanceable

Dcp-1

(Zhou et al., 1999)

Srrm1

suppressible

Dcp-1

(Fan et al., 2014)

External Data

Subunit Structure (UniProtKB)

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.

(UniProt, O02002 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63329

DroID - A comprehensive database of gene and protein interactions.

FBgn0010501

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37729

MIST (genetic) - An integrated Molecular Interaction Database

Dcp-1

MIST (protein-protein) - An integrated Molecular Interaction Database

Dcp-1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-103

Cytogenetic map

59E3-59E3

Sequence location

2R:23,551,313..23,553,547 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59E3-59E3

Limits computationally determined from genome sequence between P{lacW}l(2)s4830^s4830&P{lacW}chrw^k06908 and P{PZ}Dcp-1⁰²¹³²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

59F-59F

(Song, 1997.4.28)

59E3-59E4

(determined by in situ hybridisation)

(Spradling et al., 1999, Beaton, 1998.1.8)

59F2-59F3

(determined by in situ hybridisation)

(Beaton, 1997.12.27)

59F-59F

(determined by in situ hybridisation)

(Song et al., 1997)

59E3-59E4

59F2--3

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-103

(FlyBase, 2016)

2-108.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Bloomington

63815

y¹ w^*; Dcp-1³

63814

y¹ w^*; Dcp-1^Prev1

28909

y¹ v¹; P{TRiP.HM05120}attP2

66636

w^*; P{ST.lexA::HG}Dcp-1^VF-1

80877

y¹, v¹; P{TKO.GS04781}attP40/CyO

38315

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01779}attP2

Kyoto

108865

cn¹ P{PZ}Dcp-1⁰²¹³²/CyO; ry⁵⁰⁶

108854

y¹ w^67c23; P{lacW}Dcp-1^k05606/CyO

VDRC

v107560

P{KK106134}VIE-260B

v34328

w¹¹¹⁸; P{GD10729}v34328

v34330

w¹¹¹⁸; P{GD10729}v34330

v46616

w¹¹¹⁸; P{GD16194}v46616/TM3

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (50)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

LD13945

Other clones

DPiM_LD13945

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010501

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010501

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37729

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hasan et al., 2015)

Commercially Available Antibodies

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

9578

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Dcp-1 CG5370

(Zhang, 1999.11)

Source for database merge of

Additional comments

Other Comments

Dcp-1 is a positive regulator of starvation-induced autophagic flux during oogenesis.

(DeVorkin et al., 2014)

Loss of Dcp-1 promotes mitochondrial elongation.

(DeVorkin et al., 2014)

Dcp-1 controls autophagic flux by a mechanism involving the regulation of the mitochondrial network and maintenance of ATP levels.

(DeVorkin et al., 2014)

Pro-Dcp-1 interacts with sesB in a non-proteolytic manner to regulate its stability.

(DeVorkin et al., 2014)

Ice is activated in wing discs after irradiation.

(Florentin and Arama, 2012)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The lethality, imaginal disc and melanotic tumor phenotypes of P insertions in the overlapping Dcp-1/pita locus are caused by disruption of pita and not Dcp-1.

(Laundrie et al., 2003)

th promotes cell survival by blocking the activity of the Dcp-1 gene product.

(Wang et al., 1999)

Dcp-1 cleaves caspase substrates and induces apoptosis in cultured cells.

(McCall et al., 1997)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 68 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37729

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O02002

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010501

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010501

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dcp-1_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5370

Flygut - An atlas of the Drosophila adult midgut

FBgn0010501

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37729

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003841

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5370

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

C14.016

modMine - A data warehouse for the modENCODE project

FBgn0010501

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

10390-Dcp-1[k05606]

BioGRID - A database of protein and genetic interactions.

63329

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

9578

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

9578

DPiM - Drosophila Protein interaction map

FBgn0010501

DroID - A comprehensive database of gene and protein interactions.

FBgn0010501

DRSC - Results frm RNAi screens

FBgn0010501

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010501

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5370-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010501

FlyMine - An integrated database for Drosophila genomics

FBgn0010501

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37729

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

Dcp-1

MIST (protein-protein) - An integrated Molecular Interaction Database

Dcp-1

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG5370

(Neuert et al., 2017, Hosono et al., 2015, Chakrabarti et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Li et al., 2009, Perkins et al., 2009)

DCP1

(Wang et al., 2017, Shin et al., 2013, Kessler and Müller, 2009, Jones et al., 2000)

Dcp-1

(Bozler et al., 2019, Doktór et al., 2019, Guo et al., 2019, Park et al., 2019, Tettamanti and Casartelli, 2019, Ahmed-de-Prado et al., 2018, Chi et al., 2018, Diwanji and Bergmann, 2018, Gene Disruption Project members, 2018-, Mondal et al., 2018, Choutka et al., 2017, Nakajima and Kuranaga, 2017, Transgenic RNAi Project members, 2017-, Bhogal et al., 2016, Chen et al., 2016, Dabrowska et al., 2016, Eroglu and Derry, 2016, Kawamoto et al., 2016, Klebanow et al., 2016, Kockel et al., 2016, Melzer and Broemer, 2016, Urbach et al., 2016, Arya and White, 2015, Babcock and Ganetzky, 2015, Nicolson et al., 2015, Sakamaki et al., 2015, Sudmeier et al., 2015, Zhang et al., 2015, Bischof and FlyORF project members, 2014.6.20, DeVorkin et al., 2014, McCall, 2014.7.9, Nandi et al., 2014, Steller et al., 2014.7.9, Tamori and Deng, 2014, Yang et al., 2013, Chakrabarti et al., 2012, Chen et al., 2012, Florentin and Arama, 2012, Japanese National Institute of Genetics, 2012.5.21, Pushpavalli et al., 2012, Keller et al., 2011, Lee et al., 2011, Kim et al., 2010, Li et al., 2010, Schoenmann et al., 2010, Li et al., 2009, Hou et al., 2008, Somma et al., 2008, Buszczak et al., 2007, Copeland et al., 2007, Fan and Bergmann, 2007, Kuranaga and Miura, 2007, Langille and Clark, 2007, Liu et al., 2007, Peng et al., 2007, Baehrecke, 2006, Dworkin and Gibson., 2006, Minakhina and Steward, 2006, Moskalev et al., 2006, Muro et al., 2006, Jordan et al., 2005, Kornbluth and White, 2005, Moskalev and Zainullin, 2004, Wang et al., 1999)

Dcp1

(Ahmed-de-Prado and Baonza, 2018, Muzzopappa et al., 2017, Neuert et al., 2017, Schott et al., 2017, Sinenko, 2017, Enomoto et al., 2015, Su, 2015, Fan et al., 2014, Kim et al., 2014, Dick and Megeney, 2013, Danial and Korsmeyer, 2004, Moskalev, 2004, Di Fruscio et al., 2003, Yu et al., 2002)

ccp1

(Amarneh et al., 2009)

dcp-1

(Robin et al., 2019, Napoletano et al., 2017, Akagawa et al., 2015, Zhang et al., 2015, Lee et al., 2013, Lee et al., 2013, Yacobi-Sharon et al., 2013, Etchegaray et al., 2012, Miura, 2012, Pritchett and McCall, 2012, Fan and Bergmann, 2010, Schoenmann et al., 2010, Denton et al., 2009, Mallik and Lakhotia, 2009, Mendes et al., 2009, Xu et al., 2009, Denton et al., 2008, Fan and Bergmann, 2008, Baum et al., 2007, McCall et al., 2007, Primrose et al., 2007, Kondo et al., 2006, Leulier et al., 2006, Mendes et al., 2006, Xu et al., 2006, Xu et al., 2006, Baum et al., 2005, Kilpatrick et al., 2005, Kondo et al., 2005, Moon et al., 2005, Zheng et al., 2005, Cakouros et al., 2004, McCall, 2004, Peterson et al., 2004, Barkett et al., 2003, Bergmann et al., 2003, McCall et al., 2003, Peterson et al., 2003, Laundrie and McCall, 2002, Peterson et al., 2002, Richardson and Kumar, 2002, Buszczak et al., 2001, McCall et al., 2001, Buszczak and Cooley, 2000, Kumar and Doumanis, 2000, Vernooy et al., 2000, Bergmann et al., 1999, Varkey et al., 1999, Zhou et al., 1999, Hoffmann and Reichhart, 1997, McCall and Steller, 1997)

dcp1

(Amcheslavsky et al., 2018, Smart et al., 2017, Liang et al., 2014, Lee et al., 2013, Khammari et al., 2011, Foglietti et al., 2006, Moskalev, 2001)

l(2)01862

l(2)02132

Name Synonyms

Death caspase-1

(Klebanow et al., 2016, Steller et al., 2014.7.9, Etchegaray et al., 2012, Tsuda et al., 2006)

caspase

(Bose et al., 1998, Kondo et al., 1997)

caspase 1

(Khan et al., 2008)

caspase-1

(White et al., 1999, Song, 1997.4.28)

death caspase 1

(Urbach et al., 2016)

death caspase-1

(Mendes et al., 2009, Hou et al., 2008)

Secondary FlyBase IDs

FBgn0010509

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (257)

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