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Gene Dmel\CCS

General Information
Symbol	Dmel\CCS	Species	D. melanogaster
Name	CCS	Annotation symbol	CG17753
Feature type	protein_coding_gene	FlyBase ID	FBgn0010531
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46F1-46F1	Sequence location	2R:6,009,077..6,010,067 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CCS is referred to in FlyBase by the symbol Dmel\CCS (CG17753, FBgn0010531). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: superoxide dismutase copper chaperone activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to oxidative stress; protein stabilization. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Superoxide dismutase (Cu/Zn) / chaperones; Superoxide dismutase copper chaperone; Superoxide dismutase, copper/zinc binding domain; Superoxide dismutase, copper/zinc, binding site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1627698_at partially aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of CCS: 6 out of 14 probes fall into this exonic region. Gene sequence location is 2R:6009077..6010067.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN22475 HFA06692
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46F1-46F1   Limits computationally determined from genome sequence between P{PZ}Pfk06339&P{PZ}CCS03221 and P{lacW}Hr46k10308
Experimentally Determined Cytological Location
Cytogenetic map Notes References 46E4-46E6     (Kirby, 2001.2.1) 46F1-46F2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CCS for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CCS-RB FBtr0300944  NM_001169637   879   264
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CCS-PB   FBpp0290166   27.9   264   5.38     NP_001163108   ACZ94384
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Superoxide dismutase, copper/zinc binding domain (IPR001424) Superoxide dismutase, copper/zinc, binding site (IPR018152) Superoxide dismutase (Cu/Zn) / chaperones (IPR024134) Superoxide dismutase copper chaperone (IPR024142)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 ACZ94384   AF083312   AI389829   AQ025607   AY026866 AAK07691   AY075561 AAL68368   BI614470   BI626633   BT099568   CO192595   CO266941   CZ467555   CZ469966   CZ470050   EC065885
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9BLY4 A1Z850
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010531    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010531 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010531 expression level Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (763) embryo 02-04hr  (112) embryo 04-06hr  (163) embryo 06-08hr  (294) embryo 08-10hr  (325) embryo 10-12hr  (618) embryo 12-14hr  (368) embryo 14-16hr  (241) embryo 16-18hr  (264) embryo 18-20hr  (361) embryo 20-22hr  (404) embryo 22-24hr  (436) larva L1  (522) larva L2  (648) larva L3 12hr old  (740) larva L3 puffstage 1-2  (759) larva L3 puffstage 3-6  (875) larva L3 puffstage 7-9  (1056) white prepupae new  (979) white prepupae 12hr  (907) white prepupae 24hr  (787) pupae 2d postWPP  (533) pupae 3d postWPP  (355) pupae 4d postWPP  (488) adult male 01day  (694) adult male 05day  (917) adult male 30day  (823) adult female 01day  (739) adult female 05day  (1131) adult female 30day  (1170) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010531 expression level Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (763) embryo 02-04hr  112 embryo 04-06hr  (163) embryo 06-08hr  (294) embryo 08-10hr  (325) embryo 10-12hr  (618) embryo 12-14hr  (368) embryo 14-16hr  (241) embryo 16-18hr  (264) embryo 18-20hr  (361) embryo 20-22hr  (404) embryo 22-24hr  (436) larva L1  (522) larva L2  (648) larva L3 12hr old  (740) larva L3 puffstage 1-2  (759) larva L3 puffstage 3-6  (875) larva L3 puffstage 7-9  (1056) white prepupae new  (979) white prepupae 12hr  (907) white prepupae 24hr  (787) pupae 2d postWPP  (533) pupae 3d postWPP  (355) pupae 4d postWPP  (488) adult male 01day  (694) adult male 05day  (917) adult male 30day  (823) adult female 01day  (739) adult female 05day  (1131) adult female 30day  (1170) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    763 embryo 02-04hr    112 embryo 04-06hr    163 embryo 06-08hr    294 embryo 08-10hr    325 embryo 10-12hr    618 embryo 12-14hr    368 embryo 14-16hr    241 embryo 16-18hr    264 embryo 18-20hr    361 embryo 20-22hr    404 embryo 22-24hr    436 larva L1    522 larva L2    648 larva L3 12hr old    740 larva L3 puffstage 1-2    759 larva L3 puffstage 3-6    875 larva L3 puffstage 7-9    1056 white prepupae new    979 white prepupae 12hr    907 white prepupae 24hr    787 pupae 2d postWPP    533 pupae 3d postWPP    355 pupae 4d postWPP    488 adult male 01day    694 adult male 05day    917 adult male 30day    823 adult female 01day    739 adult female 05day    1131 adult female 30day    1170 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010531    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010531 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010531 expression level Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010531 expression level Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.675 Larval Midgut no informative data Larval Hindgut    15.7 Larval Malpighian Tubules    26.8 Larval Fat Body no informative data Larval Salivary Gland    21.1 Larval Trachea    18.675 Larval Carcass    12.225 Adult Head no informative data Adult Eye    24.7 Adult Brain    11.8 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    21.2 Adult Midgut    19 Adult Hindgut    16.8 Adult Malpighian Tubules    20.7 Adult Fat Body    20 Adult Salivary Gland no informative data Adult Heart    17.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    40.1 Adult Testis    11.8 Adult Male Accessory Gland    21.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    24.7   NA  Brain    11.8   33.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    15.6   NA  Crop    21.2   no informative data  Midgut    19   15.7  Hindgut    16.8   26.8  Malpighian Tubules    20.7   no informative data  Fat Body    20   21.1  Salivary Gland    no informative data   NA  Heart    17.175   18.675  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    12.9   NA  Ovary    40.1   NA  Testis    11.8   NA  Male Accessory Gland    21.4   12.225  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010531 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17753-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive CCS03221 viable, with Scer\GAL4pnr-MD237 CCSGD9458 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of CCS Class Mutagen Stocks Known lesion CCS29E loss of function allele P-element activity 1 Yes CCSc01928 piggyBac transposase 1 -- CCSe04167 1 -- CCSKG07046 1 -- CCS03221 P-element activity 0 -- CCSc05400 0 -- CCSc05430 piggyBac transposase 0 -- CCSc05507 piggyBac transposase 0 -- CCSEP2511 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CCS Class Mutagen Stocks Known lesion CCSGD9458 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CCSKK102394 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CCSScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)X1 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9458} NA P{KK102394} NA P{UAS-CCS.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacZ}Regio-3 No P{PZ}CCS03221 No insertion of mobile activating element P{EP}CCSEP2511 NA miscellaneous insertions P{SUPor-P}CCSKG07046 NA P{SUPor-P}KG00997 NA P{SUPor-P}KG04611 NA P{Switch2}GSG8302-2 NA PBac{PB}CCSc01928 NA PBac{PB}CCSc05400 NA PBac{PB}CCSc05430 NA PBac{PB}CCSc05507 NA PBac{RB}CCSe04167 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
superoxide dismutase copper chaperone activity inferred from direct assay (Kirby et al., 2008)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Kirby et al., 2008) protein stabilization inferred from direct assay (Kirby et al., 2008) response to oxidative stress inferred from mutant phenotype (Kirby et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
superoxide dismutase activity inferred from electronic annotation with InterPro:IPR018152 (FlyBase Curators et al., 2004-) superoxide dismutase copper chaperone activity inferred from sequence or structural similarity with EMBL:AF121906 (FlyBase, 1992-) non-traceable author statement (Kirby, 2001.2.1)
Biological Process
CV term Evidence References
intracellular copper ion transport inferred from sequence or structural similarity with EMBL:AF121906 (FlyBase, 1992-) non-traceable author statement (Kirby, 2001.2.1) oxidation-reduction process inferred from electronic annotation with InterPro:IPR001424, InterPro:IPR018152, InterPro:IPR024134 (FlyBase Curators et al., 2004-) superoxide metabolic process inferred from electronic annotation with InterPro:IPR001424, InterPro:IPR024134 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CCS allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70070 DroID - A comprehensive database of gene and protein interactions. • FBgn0010531 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46035
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11145 Dere\GG25230 Dgri\GH19972 Dmoj\GI20259 Dper\GL20081 Dpse\GA14646 Dsec\GM20549 Dsim\GD26004 Dvir\GJ20212 Dwil\GK23033 Dyak\GE21764
Curated drosophilid orthologs	Dpse\GA14646
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009436-PA Aedes aegypti (mosquito) AGAP007026-PA Anopheles gambiae (mosquito) XP_001949249.1 Acyrthosiphon pisum (pea aphid) 237553 Branchiostoma floridae (lancelet) 247007 Branchiostoma floridae (lancelet) BGIBMGA001698-PA Bombyx mori (silk worm) ENSBTAP00000005683 Bos taurus (bovine) ENSCAFP00000018281 Canis familiaris (dog) ENSCINP00000008786 Ciona intestinalis (sea squirt) cn05259 Cryptococcus neoformans (yeast-like fungus) CPIJ004568 Culex pipens (mosquito) ENSCPOP00000011879 Cavia porcellus (guinea pig) 179263 Capitella spl (polychaete worm) 265300 Daphnia pulex (daphnia) ENSDARP00000093518 Danio rerio (zebra fish) ENSECAP00000020224 Equus caballus (horse) ENSGACP00000025152 Gymnopilus aculeatus (mushroom) ENSP00000307870 Homo sapiens (human) 107910 Lottia gigantea (owl limpet) ENSMODP00000010048 Monodelphis domestica (gray opossum) ENSMMUP00000007284 Macaca mulatta (rhesus monkey) ENSMUSP00000035486 Mus musculus (house mouse) XP_001600582.1 Nasonia vitripennis (wasp) ENSORLP00000010084 Oryzias latipes (japanese killifish) 37994 Ostreococcus tauri (green alga) ENSPPYP00000003493 Pongo pygmaeus (orangutan) ENSPTRP00000006775 Pan troglodytes (chimpanzee) ENSRNOP00000026670 Rattus norvegicus (norway rat) XP_790634.1 Strongylocentrotus purpuratus (purple sea urchin) 58413 Trichoplax adhaerens (metazoa) XP_975577.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009636 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000013501 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024941 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10043 NV14239 LH23260 FBgn0239009 FBgn0224995 FBgn0207352 FBgn0197280 FBgn0175431 JGI_V11_265300 FBgn0074673 FBgn0157676 FBgn0142995 FBgn0127436 FBgn0117354 FBgn0088185 CPIJ004568 BGIBMGA001698 ACYPI003655 GB14210 AGAP007026 AAEL012368 AAEL009436 GLEAN_10027
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	24755 w*; CCS29E/CyO 14068 y1 w67c23; P{SUPor-P}CCSKG07046; P{SUPor-P}CG32452KG07046b ry506
Harvard	- PBac{RB}CCSe04167 - PBac{PB}CCSc01928, PBac{PB}c01928a, PBac{PB}c01928c
VDRC	v108665 P{KK102394}VIE-260B v20536 w1118; P{GD9458}v20536
Genomic Clones ( 1 )
	BACR09J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH67635 SD11970
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH21105 RH43840
Other clones	144940 EC34121 EK148005
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010531 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46035
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)03221 anon-EST:Posey231 (Bayraktaroglu, 2000.11.2) Source for merge of: l(2)03221 CG17753 (Misra, 2000.8.9)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001169637 RefSeq (Proteins) • NP_001163108 DDBJ / EMBL / GenBank • AAF58838 AAK07691 AAL68368 ACZ94384 AF083312 AQ025607 AY026866 AY075561 BI626633 CZ467555 CZ469966 CZ470050 Entrez Gene - A searchable database of RefSeq genes. • 46035 UniProtKB/TrEMBL • A1Z850 Q9BLY4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Superoxide dismutase, copper/zinc binding domain (IPR001424) Superoxide dismutase, copper/zinc, binding site (IPR018152) Superoxide dismutase (Cu/Zn) / chaperones (IPR024134) Superoxide dismutase copper chaperone (IPR024142)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70070 DroID - A comprehensive database of gene and protein interactions. • FBgn0010531 DRSC - Results from RNAi screens. • FBgn0010531 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010531 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17753-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010531 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46035 InParanoid A subset of ortholog calls from InParanoid. • AAEL009436-PA Aedes aegypti (mosquito) AGAP007026-PA Anopheles gambiae (mosquito) XP_001949249.1 Acyrthosiphon pisum (pea aphid) 237553 Branchiostoma floridae (lancelet) 247007 Branchiostoma floridae (lancelet) BGIBMGA001698-PA Bombyx mori (silk worm) ENSBTAP00000005683 Bos taurus (bovine) ENSCAFP00000018281 Canis familiaris (dog) ENSCINP00000008786 Ciona intestinalis (sea squirt) cn05259 Cryptococcus neoformans (yeast-like fungus) CPIJ004568 Culex pipens (mosquito) ENSCPOP00000011879 Cavia porcellus (guinea pig) 179263 Capitella spl (polychaete worm) 265300 Daphnia pulex (daphnia) ENSDARP00000093518 Danio rerio (zebra fish) ENSECAP00000020224 Equus caballus (horse) ENSGACP00000025152 Gymnopilus aculeatus (mushroom) ENSP00000307870 Homo sapiens (human) 107910 Lottia gigantea (owl limpet) ENSMODP00000010048 Monodelphis domestica (gray opossum) ENSMMUP00000007284 Macaca mulatta (rhesus monkey) ENSMUSP00000035486 Mus musculus (house mouse) XP_001600582.1 Nasonia vitripennis (wasp) ENSORLP00000010084 Oryzias latipes (japanese killifish) 37994 Ostreococcus tauri (green alga) ENSPPYP00000003493 Pongo pygmaeus (orangutan) ENSPTRP00000006775 Pan troglodytes (chimpanzee) ENSRNOP00000026670 Rattus norvegicus (norway rat) XP_790634.1 Strongylocentrotus purpuratus (purple sea urchin) 58413 Trichoplax adhaerens (metazoa) XP_975577.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009636 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000013501 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024941 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46035 modMine - Data generated by the modENCODE project. • FBgn0010531 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10043 NV14239 LH23260 FBgn0239009 FBgn0224995 FBgn0207352 FBgn0197280 FBgn0175431 JGI_V11_265300 FBgn0074673 FBgn0157676 FBgn0142995 FBgn0127436 FBgn0117354 FBgn0088185 CPIJ004568 BGIBMGA001698 ACYPI003655 GB14210 AGAP007026 AAEL012368 AAEL009436 GLEAN_10027
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-EST:Posey231   CCD (Kirby, 2001.2.1) CCS (Phillips, 2007.12.21, Nicholson et al., 2008) Ccs (Kirby et al., 2008) CG17753 (Ebner et al., 2002, Keleman et al., 2009.8.5) CG-17753 (Creagh et al., 2009) DmCCS (Norgate et al., 2006) l(2)03221 (BDGP Project Members, 1994-1999, )
Name Synonym	CCS   Cu-chaperone for superoxide dismutase (Creagh et al., 2009)
Secondary FlyBase IDs
	FBgn0025541 FBgn0033487
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...